O estudo da medula óssea em 20 casos de necrópsia de pacientes portadores da Síndrome da Imunodeficiência Adquirida sugere que as alterações medulares são freqüentes e de valor diagnóstico no reconhecimento da Síndrome. É admitida a existência de um padrão lesional diagnóstico onde predominam os seguintes elementos: hipercelularidade, ausência ou redução da granulopoiese, plasmocitose, histiocitose e displasia megacariocítica.

The bone marrow of 20 autopsy cases of patients with Acquired Immune Deficiency Syndrome was examined. The study suggests that the bone marrow changes are frequent and of diagnostic value to recognize the syndrome. It is assumed that there is a diagnostic lesional pattern in which the following elements are predominant: hypercellularity, absent or reduced granulopoiesis, plasmocytosis, histiocytosis and megakariocytic dysplasia.

We have compared differeni media and isolation procedures to cultivate Leishmania braziliensis braziliensis/rom hamster tissues. Wefmd that aspiration of the lesion using a 22 g needle and a five ml syringegives satisfactorv results, and is a convenient sampling method. Difco Blood agar is an efficient medium for isolation. Evans medium gave equal results while Schneiders and AR-103 medium were inferior. In Schneider's medium flagellate growth achieved 0.21 - 2.57 x 10(8) promastigotes/ml bv the fifth day 5-fluorocytosine added to the cultures to avoid fungal contamination does not inhibit the growth of L. b. brasiliensis.

Comparamos diferentes medios artificiales y procedimientos de cultivo in vitro de Leishmania braziliensis braziliensis (Lbb) aislada de lesiones de hamsteres experimentalmente infectados. Observamos que la aspiración de material de la lesión, usando jeringa de 5 mlyaguja 22g(25 x 8mm), mostró resultados satisfactorios siendo un procedimiento conveniente de colecta. El medio de Agar Sangre Difco (DAB) es un medio eficiente para el aislamiento de Lbb. El medio de Evans demostro similares resultados al DAB, mientras que el medio líquido de Schneider y el químicamente definido AR-103 fueron nitidamente inferiores. En la propagación in vitro de Lbb, el medio de Schneider permitió un buen crecimiento del flagelado, alcanzando densidades de 0,21 - 2,57 x 10(8) promastigotes por ml ya, en el 5.° dia de cultivo. La adición de 5-fluorocytosine a los tubos de cultivo (150/jg/ml)para evitar la contaminación por hongos, no inhibió el crecimiento de Lbb.

Os autores apresentam duas pacientes que iniciaram a doença lúpica com quadro de hemorragia cerebral. Na primeira realizou-se estudo tomográfico que revelou área compatível a sangramento no parênquima nervoso. Na segunda paciente, da gravidade do quadro decorreu o óbito, tendo sido realizado estudo anatomopatológico. São feitas considerações sobre a baixa incidência de hemorragia no SNC em pacientes com LES, a importância no presente de estudos tomográficos e a possível fisiopatogenia do quadro hemorrágico nessa colagenose.

Two patients with cerebral hemorrhage as the first manifestation of systemic lupus erythematosus (SLE) are reported. The first one showed in the CT scan blood within the brain. Laboratory findings gave the diagnosis of, lupus. She was treated with corticosteroids and plasmaferesis with good results. The second patient died within few days and the anatomopathologic study showed a large area of hemorrhage within the brain. The microscopic study of the kidney and other organs made the diagnosis of lupus erythematosus. The authors regard the intracranial bleeding as a rare complication of lupus. They consider that the CT scan must be done in all patients with central nervous system complications of SLE. They consider that the cerebral hemorrhage must be related to the autoimmune disorders that ocurr in SLE.

São relatados dois casos de mielopatia transversa subaguda associada a tumores malignos. O primeiro paciente apresentava neoplasia de células reticulares histiocitárias e o segundo, carcinoma renal. Os autores fazem revisão dos casos similares descritos na literatura. As alterações anátomo-patológicas medulares encontradas foram semelhantes às descritas nos relatos prévios, sendo que no primeiro caso havia também intenso infiltrado inflamatório perivascular e a presença de astrócitos bizarros. Tais alterações encontradas sugerem ser esta afecção de natureza viral.

Two clinico-pathological cases of necrotic myelopathies with a distant malignancy are presented. The first patient had histiocytic medullary reticulosis and the second one had a renal cell carcinoma. The authors refered to other similar cases found in the literature. In both patients the pathological features in the spinal cord were similar to the other cases reported, but in their first case they found an intense inflammatory reaction and hyperplasia of astrocytes into bizarre giant forms. The cause of necrotizing myelopathy associated with neoplasms remain unknow. The authors think that the presence of inflammatory reaction and the changes in the astrocytes in their first case are consistent with the effects of a virus.