Results: 2
#1
au:BAUMANN, K.
Filters
Order by
Page
of 1
Next
1.
Protection against cephalosporin-induced lipid peroxidation and nephrotoxicity by (+)-cyanidanol-3 and vitamin E
Facebook Twitter
Facebook Twitter
- Other social networks
- Google+
- StambleUpon
- CiteULike
- Mendeley
- Other networks
- Metrics
Brazilian Journal of Medical and Biological Research
- Journal Metrics
The ability of the clinically used cephalosporins: cephalothin, cefotaxime and cefotiam to induce lipid peroxidation (LPO) and renal damage was compared to that of nephrotoxic cephaloridine under in vivo conditions. Glutathione was measured in rat liver or in renal cortex as non-protein sulfhydryls. LPO was measured in plasma, renal cortex and liver by the generation of malondialdehyde or as the increase in renal cortical concentration of conjugated dienes. Impairment of renal function was measured as the decrease in renal cortical accumulation of the organic anion p-aminohippurate (PAH). Administration of cephalosporins to rats as a single dose (2000 mg/kg, ip) induced a significant glutathione-depletion in the renal cortex with cephaloridine, and in the liver with cephaloridine, cephalothin and cefotiam. Treatment of rats with cephaloridine, cephalothin and cefotiam (200, 500, or 1000 mg kg-1 day-1, ip) for 5 days resulted in a dose-dependent increase of LPO in the renal cortex. While cephaloridine induced the highest concentration of conjugated diene, cefotaxime had no effect. Measurements of PAH accumulation in renal cortical slices from cephalosporin-treated rats showed a dose-dependent decrease in the renal cortical accumulation of PAH. Pretreatment with the antioxidants vitamin E or cyanidanol (400 mg kg-1 day-1, ip) 1 h before treatment with cephaloridine, cephalothin or cefotiam (1000 mg kg-1 day-1, ip) for 3 days inhibited cephalosporin-induced LPO and significantly reduced the impairment of renal cortical accumulation of PAH. The potential of different cephalosporins for inducing LPO and reducing PAH accumulation was ranked as follows: cephaloridine > cephalothin > cefotiam > cefotaxime.
2461 downloads
2.
A low-mass neutron flux monitor for the n _TOF facility at CERN
Facebook Twitter
Facebook Twitter
- Other social networks
- Google+
- StambleUpon
- CiteULike
- Mendeley
- Other networks
- Metrics
Mastinu, P. F.
; Abbondanno, U.
; Aerts, G.
; Alvarez, H.
; Andriamonje, S.
; Angelopoulos, A.
; Assimakopoulos, P.
; Bacri, C.O.
; Badurek, G.
; Baumann, P.
; Becvár, F.
; Beer, H.
; Benlliure, J.
; Berthier, B.
; Berthomieux, E.
; Boffi, S.
; Borcea, C.
; Boscolo-Marchi, E.
; Bustreo, N.
; Calviño, P.
; Cano-Ott, D.
; Capote, R.
; Carlson, P.
; Cennini, P.
; Chepel, V.
; Chiaveri, E.
; Coceva, C.
; Colonna, N.
; Cortes, G.
; Cortina, D.
; Couture, A.
; Cox, J.
; Dababneh, S.
; Dahlfors, M.
; David, S.
; Dolfini, R.
; Domingo-Pardo, C.
; Duran, I.
; Eleftheriadis, C.
; Embid-Segura, M.
; Ferrant, L.
; Ferrari, A.
; Ferreira-Lourenco, L.
; Ferreira-Marques, R.
; Frais-Koelbl, H.
; Furman, W.I.
; Giomataris, Y.
; Goncalves, I.F.
; Gonzalez-Romero, E.
; Goverdovski, A.
; Gramegna, F.
; Griesmayer, E.
; Gunsing, F.
; Haight, R.
; Heil, M.
; Herrera-Martinez, A.
; Ioannides, K.G.
; Janeva, N.
; Jericha, E.
; Käppeler, F.
; Kadi, Y.
; Karamanis, D.
; Kelic, A.
; Ketlerov, V.
; Kitis, G.
; Koehler, P.E.
; Konovalov, V.
; Kossionides, E.
; Lacoste, V.
; Leeb, H.
; Lindote, A.
; Lopes, M.I.
; Loriggiola, M.
; Lozano, M.
; Lukic, S.
; Markov, S.
; Marigo, S.
; Marrone, S.
; Martinez-Val, J.
; Mengoni, A.
; Milazzo, P.M.
; Minguez, E.
; Molina-Coballes, A.
; Moreau, C.
; Neves, F.
; Oberhummer, H.
; O'Brien, S.
; Pancin, J.
; Papaevangelou, T.
; Paradela, C.
; Pavlik, A.
; Pavlopoulos, P.
; Perez-Parra, A.
; Perlado, J.M.
; Perrot, L.
; Peskov, V.
; Plag, R.
; Plompen, A.
; Plukis, A.
; Poch, A.
; Policarpo, A.
; Pretel, C.
; Quesada, J.M.
; Radici, M.
; Raman, S.
; Rapp, W.
; Rauscher, T.
; Reifarth, R.
; Rejmund, F.
; Rosetti, M.
; Rubbia, C.
; Rudolf, G.
; Rullhusen, P.
; Salgado, J.
; Savvidis, E.
; Soares, J.C.
; Stephan, C.
; Tagliente, G.
; Tain, J.L.
; Tapia, C.
; Tassan-Got, L.
; Tavora, L.M.N.
; Terlizzi, R.
; Terrani, M.
; Tsangas, N.
; Vannini, G.
; Vaz, P.
; Ventura, A.
; Villamarin-Fernandez, D.
; Vincente-Vincente, M.
; Vlachoudis, V.
; Vlastou, R.
; Voss, F.
; Wendler, H.
; Wiescher, M.
; Wisshak, K.
; Zanini, L.
.
A small-mass system has been developed for monitoring the flux of neutrons with energy up to 1 MeV at the new time-of-flight facility at CERN, n_TOF. The monitor is based on a thin Mylar foil with a 6Li deposit, placed in the neutron beam, and an array of Silicon detectors, placed outside the beam, for detecting the products of the 6Li(n, alpha)³H reaction. The small amount of material on the beam ensures a minimal perturbation of the flux and minimizes the background related to scattered neutrons. Moreover, a further reduction of the gamma-ray background has been obtained by constructing the scattering chamber hosting the device in carbon fibre. A detailed description of the flux monitor is here presented, together with the characteristics of the device, in terms of efficiency, resolution and induced background. The use of the monitor in the measurement of neutron capture cross-sections at n_TOF is discussed
1444 downloads
Showing
itens per page
Page
of 1
Next
Statistics of
Send result
Sem resultados
No documents were found for your search
Glossary and search help
You can enrich your search in a very simple way. Use the search indexes combined with the connectors (AND or OR) and specify more your search.
For example, if you want to search for articles about
cases of dengue in Brasil in 2015, use:ti:dengue and publication_year:2015 and aff_country:Brasil
See below the complete list of search indexes that can be used:
Index code | Element |
---|---|
ti | article title |
au | author |
kw | article keywords |
subject | subject (title words, abstract and keywords) |
ab | abstract |
ta | journal short title (e.g. Cad. Saúde Pública) |
journal_title | journal full title (e.g. Cadernos de Saúde Pública) |
la | publication language code (e.g. pt - Portuguese, es - Spanish) |
type | document type |
pid | publication identifier |
publication_year | publication year of publication |
sponsor | sponsor |
aff_country | country code of the author's affiliation |
aff_institution | author affiliation institution |
volume | article volume |
issue | article issue |
elocation | elocation |
doi | DOI number |
issn | journal ISSN |
in | SciELO colection code (e.g. scl - Brasil, col - Colômbia) |
use_license | article usage license code |