ABSTRACT Objective To describe of the translation from English to Portuguese and adaption process of subitems of the Functional Assessment of Cancer Therapy – Multiple Myeloma. Methods In the first phase, translations from English into Portuguese of two subitems of Functional Assessment of Cancer Therapy – Multiple Myeloma were performed. Subsequently, a consensus and back translation were conducted, and, finally, translation and back translations were reviewed by four independent bilingual experts. In the second phase, the translated subitems were applied, along with a questionnaire, to 10 native Portuguese speakers patients with multiple myeloma. Results There was a recognition of the translation process in its first version applied to 10 patients with multiple myeloma, whose reported no difficult to understand the translated and validated instrument. Patients also did not find the content irrelevant or offensive, and they did not suggested changes. Conclusion The subitems of the Functional Assessment of Cancer Therapy – Multiple Myeloma were translated from English into Portuguese following the proposed methodology and there was not need of readjustments. This process allowed this instrument of quality of life, which is widely known to be beneficial in the management of patients with multiple myeloma, to be used among our population.

Objetivou-se estudar os efeitos da combinação de ácido L-glutâmico (L-Glu) e vitamina K na composição bioquímica de fêmures (proteínas colagenosas; não-colagenosas e totais) de frangos de corte. O experimento, que teve 14 dias de duração, foi conduzido em delineamento inteiramente casualizado, em fatorial 2 × 4, com dois níveis de ácido L-glutâmico (6,25 e 12,5%) combinados com quatro níveis de vitamina K (0,02; 0,2; 2,0 e 20,0 mg/kg de ração), cada combinação com quatro repetições de dez animais. Foram utilizados pintos machos, Avian Farm, de 1 dia, criados em baterias aquecidas e alimentados à vontade com dieta básica contendo L-aminoácidos essenciais, minerais e vitaminas (exceto vitamina K) suplementada com ácido L-glutâmico e vitamina K. Ao término do experimento, os animais foram sacrificados por deslocamento cervical e seus fêmures removidos, medidos, desengordurados e pesados. Não foi observada interação significativa entre ácido L-glutâmico e vitamina K para os parâmetros estudados. Os teores de proteínas não-colagenosas foram maiores e o de proteínas colagenosas, menores nos fêmures dos pintos alimentados com a ração com 6,25% de ácido L-glutâmico. Os teores de proteínas totais, no entanto, não foram afetados pelos níveis de ácido L-glutâmico e de vitamina K. Os níveis de vitamina K tiveram efeito quadrático decrescente nos teores de proteínas não-colagenosas e efeito crescente na composição de proteínas colagenosas dos fêmures. A composição em proteínas colagenosas e não-colagenosas pode ser utilizada como indicador bioquímico de anormalidades de pernas causadas por baixo nível de nitrogênio não-específico.

This work aimed to study the effects of L-glutamic acid (L-Glu) and K vitamin on the biochemical composition (collagenous proteins, CP; non collagenous proteins, NCP; and total proteins, TP) in femurs of broilers. The experiment which lasted for 14 days, was carried out in a completely randomized design in a 2 × 4 factorial with two levels of L-glutamic acid (6.25% and 12.5%) combined with four levels of K vitamin (0.02; 0.2; 2.0 and 20.0 mg of feed) each combination with four replicates of 10 animals. It was used Avian farm male broilers at 1 day of age, reared in electrically heated batteries with raised wire mesh floors and they were fed ad libitum with a basic diet containing essential L-amino acids, minerals and K vitamin. At the end of the experiment, the broilers were sacrificed through cervical dislocation and their femurs were removed, measured, fat removed and weighted. It was not observed a significant interaction among Lglutamic acid and K vitamin for the studied parameters. The non-collagenous protein levels were higher and the collagenous proteins levels were lower in the femurs of the animals fed with 6.25% of L-Glu. However, the total protein levels were not affected by the levels of L-glutamic acid and K vitamin. The levels of K vitamin had a decreasing quadratic effect on the levels of non-collagenous proteins and increasing effect on the level of collageonous proteins in the femurs. The composition on collagenous and non collagenous proteins can be used as a biochemical marker of leg abnormalities caused by low level of non-specific nitrogen.