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ABSTRACT Purpose: To evaluate the tissue content of neutral and acidic mucins, sulfomucins and sialomucins in colonic glands devoid of intestinal transit after enemas containing sucralfate and n-acetylcysteine alone or in combination. Methods: Sixty-four rats underwent intestinal transit bypass. A colonic segment was collected to compose the white group (without intervention). After derivation, the animals were divided into two groups according to whether enemas were performed daily for two or four weeks. Each group was subdivided into four subgroups according to the substance used: control group: saline 0.9%; sucralfate group (SCF): SCF 2 g/kg/day; n-acetylcysteine group (NAC): NAC 100 mg/kg/day; and SCF+NAC group: SCF 2 g/kg/day + NAC 100 mg/kg/day.Neutral and acidic mucins were stained by periodic acid-Schiff and alcian-blue techniques, respectively. The distinction between sulfomucins and sialomucin was made by the high alcian-blue iron diamine technique. The content of mucins in the colonic glands was measured by computerized morphometry. The inflammatory score was assessed using a validated scale. The results between the groups were compared by the Mann-Whitney’s test, while the variation according to time by the Kruskal-Wallis’ test (Dunn’s post-test). A significance level of 5% was adopted. Results: There was reduction in the inflammatory score regardless of the application of isolated or associated substances. Intervention with SCF+NAC increased the content of all mucin subtypes regardless of intervention time. Conclusions: The application of SCF+NAC reduced the inflammatory process of the colonic mucosa and increased the content of different types of mucins in the colonic glands of segments excluded from fecal transit.

https://doi.org/10.1590/acb384023

Stability of potato clones resistant to potato virus Y under subtropical conditions
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Andrade, Mario Henrique Murad Leite

; Patiño-Torres, Albania José

; Cavallin, Isabella Cristina

; Guedes, Marcio Lisboa

; Carvalho, Rafaela Pereira

; Gonçalves, Flávia Maria Avelar

; Marçal, Tiago de Souza

; Pinto, César Augusto Brasil Pereira

Crop Breeding and Applied Biotechnology

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2021, Volume 21 N. 1 elocation e32872118

Abstract: En | Text: En | PDF: En

Abstract Brazilian potato production is based on cultivars originating from the USA and Europe; however, these cultivars were developed under different environmental conditions than those found in Brazil. The aim of this study was to evaluate the adaptability and stability of 18 potato clones (MLG), developed by the Universidade Federal de Lavras, and four cultivars in six environments in the state of Minas Gerais, Brazil. The following traits were evaluated: marketable tuber yield (MTY), specific gravity (SG), and tuber appearance (TA). Clones, environments, and the genotype × environment interaction had significant effects on all traits. The GGE-biplot explained 71.78, 98.13, and 62.86 % of the sum of squares from the G+G×E for MTY, SG, and TA, respectively. Three MLG clones had higher adaptability and stability, as well as better performance, than the cultivars, making them good candidates for release as cultivars.

https://doi.org/10.1590/1984-70332021v21n1a8 186 downloads

Epidemiologia e desfecho dos pacientes de alto risco cirúrgico admitidos em unidades de terapia intensiva no Brasil
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Silva Júnior, João Manoel

; Chaves, Renato Carneiro de Freitas

; Corrêa, Thiago Domingos

; Assunção, Murillo Santucci Cesar de

; Katayama, Henrique Tadashi

; Bosso, Fabio Eduardo

; Amendola, Cristina Prata

; Serpa Neto, Ary

; Malbouisson, Luiz Marcelo Sá

; Oliveira, Neymar Elias de

; Veiga, Viviane Cordeiro

; Rojas, Salomón Soriano Ordinola

; Postalli, Natalia Fioravante

; Alvarisa, Thais Kawagoe

; Lucena, Bruno Melo Nobrega de

; Oliveira, Raphael Augusto Gomes de

; Sanches, Luciana Coelho

; Silva, Ulysses Vasconcellos de Andrade e

; Nassar Junior, Antonio Paulo

; Réa-Neto, Álvaro

; Amaral, Alexandre

; Teles, José Mário

; Freitas, Flávio Geraldo Rezende de

; Bafi, Antônio Tonete

; Pacheco, Eduardo Souza

; Ramos, Fernando José

; Vieira Júnior, José Mauro

; Pereira, Maria Augusta Santos Rahe

; Schwerz, Fábio Sartori

; Menezes, Giovanna Padoa de

; Magalhães, Danielle Dourado

; Castro, Cristine Pilati Pileggi

; Henrich, Sabrina Frighetto

; Toledo, Diogo Oliveira

; Parra, Bruna Fernanda Camargo Silva

; Dias, Fernando Suparregui

; Zerman, Luiza

; Formolo, Fernanda

; Nobrega, Marciano de Sousa

; Piras, Claudio

; Piras, Stéphanie de Barros

; Conti, Rodrigo

; Bittencourt, Paulo Lisboa

; D’Oliveira, Ricardo Azevedo Cruz

; Estrela, André Ricardo de Oliveira

; Oliveira, Mirella Cristine de

; Reese, Fernanda Baeumle

; Motta Júnior, Jarbas da Silva

; Câmara, Bruna Martins Dzivielevski da

; David-João, Paula Geraldes

; Tannous, Luana Alves

; Chaiben, Viviane Bernardes de Oliveira

; Miranda, Lorena Macedo Araújo

; Brasil, José Arthur dos Santos

; Deucher, Rafael Alexandre de Oliveira

; Ferreira, Marcos Henrique Borges

; Vilela, Denner Luiz

; Almeida, Guilherme Cincinato de

; Nedel, Wagner Luis

; Passos, Matheus Golenia dos

; Marin, Luiz Gustavo

; Oliveira Filho, Wilson de

; Coutinho, Raoni Machado

; Oliveira, Michele Cristina Lima de

; Friedman, Gilberto

; Meregalli, André

; Höher, Jorge Amilton

; Soares, Afonso José Celente

; Lobo, Suzana Margareth Ajeje

Revista Brasileira de Terapia Intensiva

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mar 2020, Volume 32 N. 1 Pages 17 - 27

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Definir o perfil epidemiológico e os principais determinantes de morbimortalidade dos pacientes cirúrgicos não cardíacos de alto risco no Brasil. Métodos: Estudo prospectivo, observacional e multicêntrico. Todos os pacientes cirúrgicos não cardíacos admitidos nas unidades de terapia intensiva, ou seja, considerados de alto risco, no período de 1 mês, foram avaliados e acompanhados diariamente por, no máximo, 7 dias na unidade de terapia intensiva, para determinação de complicações. As taxas de mortalidade em 28 dias de pós-operatório, na unidade de terapia intensiva e hospitalar foram avaliadas. Resultados: Participaram 29 unidades de terapia intensiva onde foram realizadas cirurgias em 25.500 pacientes, dos quais 904 (3,5%) de alto risco (intervalo de confiança de 95% - IC95% 3,3% - 3,8%), tendo sido incluídos no estudo. Dos pacientes envolvidos, 48,3% eram de unidades de terapia intensiva privadas e 51,7% de públicas. O tempo de internação na unidade de terapia intensiva foi de 2,0 (1,0 - 4,0) dias e hospitalar de 9,5 (5,4 - 18,6) dias. As taxas de complicações foram 29,9% (IC95% 26,4 - 33,7) e mortalidade em 28 dias pós-cirurgia 9,6% (IC95% 7,4 - 12,1). Os fatores independentes de risco para complicações foram Simplified Acute Physiology Score 3 (SAPS 3; razão de chance − RC = 1,02; IC95% 1,01 - 1,03) e Sequential Organ Failure Assessment Score (SOFA) da admissão na unidade de terapia intensiva (RC =1,17; IC95% 1,09 - 1,25), tempo de cirurgia (RC = 1,001; IC95% 1,000 - 1,002) e cirurgias de emergências (RC = 1,93; IC95% 1,10 - 3,38). Em adição, foram associados com mortalidade em 28 dias idade (RC = 1,032; IC95% 1,011 - 1,052) SAPS 3 (RC = 1,041; IC95% 1,107 - 1,279), SOFA (RC = 1,175; IC95% 1,069 - 1,292) e cirurgias emergenciais (RC = 2,509; IC95% 1,040 - 6,051). Conclusão: Pacientes com escores prognósticos mais elevados, idosos, tempo cirúrgico e cirurgias emergenciais estiveram fortemente associados a maior mortalidade em 28 dias e mais complicações durante permanência em unidade de terapia intensiva.

ABSTRACT Objective: To define the epidemiological profile and the main determinants of morbidity and mortality in noncardiac high surgical risk patients in Brazil. Methods: This was a prospective, observational and multicenter study. All noncardiac surgical patients admitted to intensive care units, i.e., those considered high risk, within a 1-month period were evaluated and monitored daily for a maximum of 7 days in the intensive care unit to determine complications. The 28-day postoperative, intensive care unit and hospital mortality rates were evaluated. Results: Twenty-nine intensive care units participated in the study. Surgeries were performed in 25,500 patients, of whom 904 (3.5%) were high-risk (95% confidence interval - 95%CI 3.3% - 3.8%) and were included in the study. Of the participating patients, 48.3% were from private intensive care units, and 51.7% were from public intensive care units. The length of stay in the intensive care unit was 2.0 (1.0 - 4.0) days, and the length of hospital stay was 9.5 (5.4 - 18.6) days. The complication rate was 29.9% (95%CI 26.4 - 33.7), and the 28-day postoperative mortality rate was 9.6% (95%CI 7.4 - 12.1). The independent risk factors for complications were the Simplified Acute Physiology Score 3 (SAPS 3; odds ratio - OR = 1.02; 95%CI 1.01 - 1.03) and Sequential Organ Failure Assessment Score (SOFA) on admission to the intensive care unit (OR = 1.17; 95%CI 1.09 - 1.25), surgical time (OR = 1.001, 95%CI 1.000 - 1.002) and emergency surgeries (OR = 1.93, 95%CI, 1.10 - 3.38). In addition, there were associations with 28-day mortality (OR = 1.032; 95%CI 1.011 - 1.052), SAPS 3 (OR = 1.041; 95%CI 1.107 - 1.279), SOFA (OR = 1.175, 95%CI 1.069 - 1.292) and emergency surgeries (OR = 2.509; 95%CI 1.040 - 6.051). Conclusion: Higher prognostic scores, elderly patients, longer surgical times and emergency surgeries were strongly associated with higher 28-day mortality and more complications during the intensive care unit stay.

https://doi.org/10.5935/0103-507x.20200005 1048 downloads

O Brasil na crise das ilhas Chincha: a atuação diplomática de Francisco de Varnhagen (1864-1866)
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Miranda Doctor en História Iberoamericana por la Pontifícia Universidade Católica do Rio Grande do Sul - Brasil. Profesor Asistente Ibmec Business School - Rio de Janeiro- Brasil, José Augusto Ribas

Relaciones internacionales

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jan 2020, Volume 29 N. 58 Pages 59 - 80

Abstract: Es En Pt | Text: Es En Pt | PDF: Es | PDF: En | PDF: Pt

Resumen Este artículo analiza la participación del diplomático brasileño Francisco Adolfo de Varnhagen durante la crisis de las islas Chincha que enfrentó a España con Perú, Chile, Ecuador y Bolivia entre los años 1864-1866. La participación de Varnhagen da cuenta del dudoso posicionamiento de la cancillería brasileña frente a un conflicto que involucró países sudamericanos vecinos y potencias europeas, lo que ilustra las contradicciones de la política externa de Brasil en el ámbito de las relaciones diplomáticas que involucraban a Europa y América. Varnhagen contradijo las disposiciones de neutralidad dispuestas por Itamaraty, al enviar notas de apoyo a los vecinos sudamericanos, lo que le valió ser reprendido. El artículo recurre a la extensa documentación diplomática brasileña y ofrece nuevas perspectivas para entender un conflicto de gran importancia para la historiografía peruana, chilena y española.

Abstract This paper analyzes Brazilian diplomat Francisco Adolfo de Varnhagen’s performance during the crisis on the Chincha islands, which entailed the confrontations between Spain and Peru, Chile, Ecuador and Bolivia from 1864 to 1866. Varnhagen’s participation shows Brazil’s Foreign Affairs Office’s dubious position within a conflict involving neighboring South American countries and European powers, exemplifying the contradictions of Brazilian foreign policy in the field of diplomatic relations between Europe and America. Varnhagen went against the neutrality provisions set forth by Itamaraty, by sending support notes to the South American neighbors, which caused him to be reprimanded. This paper makes use of the vast number of Brazilian diplomatic documents and offers new perspectives to understand a very significant conflict for the Peruvian, Chilean and Spanish historiographies.

Resumo Este artigo analisa a atuação do diplomata brasileiro Francisco Adolfo de Varnhagen durante a crise das ilhas Chincha, que colocou Espanha contra Peru, Chile, Equador e Bolívia entre os anos de 1864 e 1866. A atuação de Varnhagen demonstra o posicionamento dúbio da chancelaria brasileira ante a conflitos entre vizinhos sul-americanos e potências europeias, ilustrando as inseguranças da política externa brasileira entre a Europa e a América. Varnhagen contrariou as disposições essencialmente neutras do Itamaraty, soltando notas de apoio aos vizinhos sul-americanos, e foi repreendido por isso. O artigo lança mão de extensa documentação diplomática brasileira e fornece novas perspectivas para entender este conflito importante na historiografia peruana, chilena e espanhola.

Characteristics and outcomes of patients with COVID-19 admitted to the ICU in a university hospital in São Paulo, Brazil - study protocol
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Ferreira, Juliana C.

; Ho, Yeh-Li

; Besen, Bruno A.M.P.

; Malbuisson, Luiz M.S.

; Taniguchi, Leandro U.

; Mendes, Pedro V.

; Costa, Eduardo L.V.

; Park, Marcelo

; Daltro-Oliveira, Renato

; Roepke, Roberta M.L.

; Silva Jr, João M.

; Carmona, Maria José C.

; Carvalho, Carlos Roberto Ribeiro

; Hirota, Adriana

; Kanasiro, Alberto Kendy

; Crescenzi, Alessandra

; Fernandes, Amanda Coelho

; Miethke-Morais, Anna

; Bellintani, Arthur Petrillo

; Canasiro, Artur Ribeiro

; Carneiro, Bárbara Vieira

; Zanbon, Beatriz Keiko

; Batista, Bernardo Pinheiro De Senna Nogueira

; Nicolao, Bianca Ruiz

; Besen, Bruno Adler Maccagnan Pinheiro

; Biselli, Bruno

; Macedo, Bruno Rocha De

; Toledo, Caio Machado Gomes De

; Pompilio, Carlos Eduardo

; Carvalho, Carlos Roberto Ribeiro De

; Mol, Caroline Gomes

; Stipanich, Cassio

; Bueno, Caue Gasparotto

; Garzillo, Cibele

; Tanaka, Clarice

; Forte, Daniel Neves

; Joelsons, Daniel

; Robira, Daniele

; Costa, Eduardo Leite Vieira

; Silva Júnior, Elson Mendes Da

; Regalio, Fabiane Aliotti

; Segura, Gabriela Cardoso

; Marcelino, Gustavo Brasil

; Louro, Giulia Sefrin

; Ho, Yeh-Li

; Ferreira, Isabela Argollo

; Gois, Jeison de Oliveira

; Silva Junior, Joao Manoel Da

; Reusing Junior, Jose Otto

; Ribeiro, Julia Fray

; Ferreira, Juliana Carvalho

; Galleti, Karine Vusberg

; Silva, Katia Regina

; Isensee, Larissa Padrao

; Oliveira, Larissa dos Santos

; Taniguchi, Leandro Utino

; Letaif, Leila Suemi

; Lima, Lígia Trombetta

; Park, Lucas Yongsoo

; Chaves Netto, Lucas

; Nobrega, Luciana Cassimiro

; Haddad, Luciana

; Hajjar, Ludhmila

; Malbouisson, Luiz Marcelo

; Pandolfi, Manuela Cristina Adsuara

; Park, Marcelo

; Carmona, Maria José Carvalho

; Andrade, Maria Castilho Prandini H De

; Santos, Mariana Moreira

; Bateloche, Matheus Pereira

; Suiama, Mayra Akimi

; Oliveira, Mayron Faria de

; Sousa, Mayson Laercio

; Louvaes, Michelle

; Huemer, Natassja

; Mendes, Pedro

; Lins, Paulo Ricardo Gessolo

; Santos, Pedro Gaspar Dos

; Moreira, Pedro Ferreira Paiva

; Guazzelli, Renata Mello

; Reis, Renato Batista Dos

; Oliveira, Renato Daltro De

; Roepke, Roberta Muriel Longo

; Pedro, Rodolpho Augusto De Moura

; Kondo, Rodrigo

; Rached, Samia Zahi

; Fonseca, Sergio Roberto Silveira Da

; Borges, Thais Sousa

; Ferreira, Thalissa

; Cobello Junior, Vilson

; Sales, Vivian Vieira Tenório

; Ferreira, Willaby Serafim Cassa

Clinics

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2020, Volume 75 elocation e2294

Abstract: En | Text: En | PDF: En

OBJECTIVES: We designed a cohort study to describe characteristics and outcomes of patients with coronavirus disease (COVID-19) admitted to the intensive care unit (ICU) in the largest public hospital in Sao Paulo, Brazil, as Latin America becomes the epicenter of the pandemic. METHODS: This is the protocol for a study being conducted at an academic hospital in Brazil with 300 adult ICU beds dedicated to COVID-19 patients. We will include adult patients admitted to the ICU with suspected or confirmed COVID-19 during the study period. The main outcome is ICU survival at 28 days. Data will be collected prospectively and retrospectively by trained investigators from the hospital’s electronic medical records, using an electronic data capture tool. We will collect data on demographics, comorbidities, severity of disease, and laboratorial test results at admission. Information on the need for advanced life support and ventilator parameters will be collected during ICU stay. Patients will be followed up for 28 days in the ICU and 60 days in the hospital. We will plot Kaplan-Meier curves to estimate ICU and hospital survival and perform survival analysis using the Cox proportional hazards model to identify the main risk factors for mortality. ClinicalTrials.gov: NCT04378582. RESULTS: We expect to include a large sample of patients with COVID-19 admitted to the ICU and to be able to provide data on admission characteristics, use of advanced life support, ICU survival at 28 days, and hospital survival at 60 days. CONCLUSIONS: This study will provide epidemiological data about critically ill patients with COVID-19 in Brazil, which could inform health policy and resource allocation in low- and middle-income countries.

https://doi.org/10.6061/clinics/2020/e2294 1957 downloads

Updated Cardiovascular Prevention Guideline of the Brazilian Society of Cardiology - 2019
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Précoma, Dalton Bertolim

; Oliveira, Gláucia Maria Moraes de

; Simão, Antonio Felipe

; Dutra, Oscar Pereira

; Coelho, Otávio Rizzi

; Izar, Maria Cristina de Oliveira

; Póvoa, Rui Manuel dos Santos

; Giuliano, Isabela de Carlos Back

; Alencar Filho, Aristóteles Comte de

; Machado, Carlos Alberto

; Scherr, Carlos

; Fonseca, Francisco Antonio Helfenstein

; Santos Filho, Raul Dias dos

; Carvalho, Tales de

; Avezum Jr., Álvaro

; Esporcatte, Roberto

; Nascimento, Bruno Ramos

; Brasil, David de Pádua

; Soares, Gabriel Porto

; Villela, Paolo Blanco

; Ferreira, Roberto Muniz

; Martins, Wolney de Andrade

; Sposito, Andrei C.

; Halpern, Bruno

; Saraiva, José Francisco Kerr

; Carvalho, Luiz Sergio Fernandes

; Tambascia, Marcos Antônio

; Coelho-Filho, Otávio Rizzi

; Bertolami, Adriana

; Correa Filho, Harry

; Xavier, Hermes Toros

; Faria-Neto, José Rocha

; Bertolami, Marcelo Chiara

; Giraldez, Viviane Zorzanelli Rocha

; Brandão, Andrea Araújo

; Feitosa, Audes Diógenes de Magalhães

; Amodeo, Celso

; Souza, Dilma do Socorro Moraes de

; Barbosa, Eduardo Costa Duarte

; Malachias, Marcus Vinícius Bolívar

; Souza, Weimar Kunz Sebba Barroso de

; Costa, Fernando Augusto Alves da

; Rivera, Ivan Romero

; Pellanda, Lucia Campos

; Silva, Maria Alayde Mendonça da

; Achutti, Aloyzio Cechella

; Langowiski, André Ribeiro

; Lantieri, Carla Janice Baister

; Scholz, Jaqueline Ribeiro

; Ismael, Silvia Maria Cury

; Ayoub, José Carlos Aidar

; Scala, Luiz César Nazário

; Neves, Mario Fritsch

; Jardim, Paulo Cesar Brandão Veiga

; Fuchs, Sandra Cristina Pereira Costa

; Jardim, Thiago de Souza Veiga

; Moriguchi, Emilio Hideyuki

; Schneider, Jamil Cherem

; Assad, Marcelo Heitor Vieira

; Kaiser, Sergio Emanuel

; Lottenberg, Ana Maria

; Magnoni, Carlos Daniel

; Miname, Marcio Hiroshi

; Lara, Roberta Soares

; Herdy, Artur Haddad

; Araújo, Cláudio Gil Soares de

; Milani, Mauricio

; Silva, Miguel Morita Fernandes da

; Stein, Ricardo

; Lucchese, Fernando Antonio

; Nobre, Fernando

; Griz, Hermilo Borba

; Magalhães, Lucélia Batista Neves Cunha

; Borba, Mario Henrique Elesbão de

; Pontes, Mauro Ricardo Nunes

; Mourilhe-Rocha, Ricardo

Arquivos Brasileiros de Cardiologia

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oct 2019, Volume 113 N. 4 Pages 787 - 891

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.5935/abc.20190204 40841 downloads

Influence of advanced age on postoperative outcomes and total loss following breast reconstruction: a critical assessment of 560 cases
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MATSUMOTO, WALTER KOITI

; MUNHOZ, ALEXANDRE MENDONÇA

; OKADA, ALBERTO

; MONTAG, EDUARDO

; ARRUDA, EDUARDO GUSTAVO

; FONSECA, ALEXANDRE

; FERRARI, ORLANDO

; BRASIL, JOSÉ AUGUSTO

; PRETTI, LIA

; FILASSI, JOSÉ ROBERTO

; GEMPERLI, ROLF

Revista do Colégio Brasileiro de Cirurgiões

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2018, Volume 45 N. 2 elocation e1616

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: avaliar o papel da idade no risco de complicações pós-operatórias de pacientes submetidas à reconstrução mamária unilateral pós-mastectomia, com ênfase na perda total da reconstrução. Métodos: estudo retrospectivo de pacientes submetidas à reconstrução mamária, cujas variáveis incluídas foram: dados oncológicos e da técnica de reconstrução, complicações pós-operatórias, incluindo perda da reconstrução e complicações da ferida operatória. As pacientes foram divididas de acordo com a classificação da Política Nacional do Idoso e Estatuto do Idoso em dois grupos: jovens (idade <60 anos) e idosas (60 anos ou mais). Também foram agrupadas de acordo com a classificação da Organização Mundial da Saúde: jovens (idade <44 anos); meia-idade (idade 45-59 anos); idosas (idade 60-89 anos) e velhice extrema (90 anos ou mais). A classificação do risco cirúrgico da Sociedade Americana de Anestesiologistas foi aplicada para investigar o papel do estado físico pré-operatório como possível preditor de complicações. Resultados: das 560 pacientes operadas, 94 (16,8%) apresentavam 60 anos ou mais. Observou-se taxa de complicações locais de 49,8%, a maioria, limitadas. As incidências de necrose, infecção e deiscência foram de 15,5%, 10,9% e 9,3%, respectivamente. Pacientes com 60 anos ou mais apresentaram chance de complicação 1,606 vezes maior do que as jovens. Quarenta e cinco (8%) pacientes apresentaram perda da reconstrução e não houve diferença estatisticamente significante na média de idade das pacientes que apresentaram ou não esse desfecho (p=0,321). Conclusão: em pacientes selecionadas, a reconstrução mamária pode ser considerada segura; a maioria das complicações documentadas foi limitada e pode ser tratada conservadoramente.

ABSTRACT Objective: to evaluate the role of age in the risk of postoperative complications in patients submitted to unilateral breast reconstruction after mastectomy, with emphasis on total reconstruction loss. Methods: we conducted a retrospective study of patients submitted to breast reconstruction, whose variables included: oncological and reconstruction data, postoperative complications, including loss of reconstruction and complications of surgical wound. We divided the patients into two groups, according to the classification of the Brazilian National Elderly Policy and the Statute of the Elderly: young (age <60 years) and elderly (60 years or more). We also grouped them according to the World Health Organization classification: young people (age <44 years), middle age (45-59 years); elderly (age 60-89 years) and extreme advanced age (90 years or older). We applied the surgical risk classification of the American Society of Anesthesiologists to investigate the role of the preoperative physical state as a possible predictor of complications. Results: of the 560 patients operated on, 94 (16.8%) were 60 years of age or older. We observed a local complication rate of 49.8%, the majority being self-limited. The incidences of necrosis, infection and dehiscence were 15.5%, 10.9% and 9.3%, respectively. Patients older than 60 years presented a chance of complication 1.606 times greater than the younger ones. Forty-five (8%) patients had loss of the reconstruction; there was no statistically significant difference in the mean age of the patients who presented this result or not (p=0.321). Conclusion: in selected patients, breast reconstruction can be considered safe; most documented complications were limited and could be treated conservatively.

https://doi.org/10.1590/0100-6991e-20181616 1852 downloads

Sperm Quality and Testicular Histomorphometry of Wistar Rats Supplemented with Extract and Fractions of Fruit of Tribulus terrestris L.
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Oliveira, Nelma Neylanne Pinho Muniz

; Félix, Matheus Augusto Rodrigues

; Pereira, Tauany Costa Silva

; Rocha, Luiz Gustavo Pessoa

; Miranda, José Rafael

; Zangeronimo, Márcio Gilberto

; Pinto, José Eduardo Brasil Pereira

; Bertolucci, Suzan Kelly Vilela

; Sousa, Raimundo Vicente de

Brazilian Archives of Biology and Technology

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dec 2015, Volume 58 N. 6 Pages 891 - 897

Abstract: En | Text: En | PDF: En

ABSTRACT The aim of this study was to assess the sperm quality and testicular histomorphometry of Wistar rats supplemented with extract and fractions of fruits of Tribulus terrestris L. The ethanolic extract was obtained by dynamic maceration of spray-dried fruit. This extract was fractionated by liquid-liquid partition, using increasing polarity solvents. Twenty male rats were separated in four groups, with five rats in each group. The control was supplemented with distilled water, while the others were daily given the ethanolic extract, hexanic or aqueous fraction soluble in methanol in a dose of 42 mg.kg-1.day-1 for 70 days. Sperm was obtained from the right epididymal tail for the analysis of motility, count, morphology and viability. The testicular weight of groups supplemented with ethanolic extract and aqueous fraction soluble in methanol was higher when compared to the control. The gonadosomatic index increased in the group supplemented with ethanolic extract. The nuclear, cytoplasmic and individual volume of Leydig cells increased in supplementation with hexanic and aqueous fractions soluble in methanol. It was concluded that the extract influenced the spermatogenesis, while hexanic and aqueous fractions soluble in methanol promoted the changes in the intertubular compartment. Therefore, Tribulus terrestris did not improve the sperm quality of the rats.

https://doi.org/10.1590/S1516-89132015060278 4985 downloads

Orientação nutricional de crianças e adolescentes e os novos padrões de consumo: propagandas, embalagens e rótulos
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Pontes, Tatiana Elias

; Costa, Thalita Feitosa

; Marum, Annete Bressan R. F.

; Brasil, Anne Lise D.

; Taddei, José Augusto de A. C.

Revista Paulista de Pediatria

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mar 2009, Volume 27 N. 1 Pages 99 - 105

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

OBJETIVO: Compilar e debater conhecimentos sobre os rótulos, as embalagens e a divulgação e promoção de alimentos processados que progressivamente passam a compor a dieta da população infanto-juvenil. FONTES DE DADOS: Artigos nos bancos de dados eletrônicos, Medline e SciELO nos últimos dez anos, nas línguas portuguesa e inglesa, utilizando os descritores "criança", "marketing", "hábitos alimentares", "televisão", "educação em Saúde". Também foram consultados livros, textos recentes e artigos considerados relevantes para realização dessa revisão. SÍNTESE DOS DADOS: O artigo discute o marketing de alimentos, segundo os tópicos: propagandas, embalagens e rótulos. Quanto à publicidade televisiva, foi abordada sua influência na formação dos hábitos alimentares infanto-juvenis, a qualidade nutricional dos alimentos veiculados e as alternativas para que pais e educadores possam lidar com os novos padrões de consumo. Além disso, debateram-se as embalagens enquanto meios de comunicação entre fabricante e consumidor. Sobre os rótulos, foram abordadas as novas regras da Agência Nacional de Vigilância Sanitária a respeito da Rotulagem Nutricional Obrigatória, bem como a importância da leitura adequada para a adoção de escolhas alimentares saudáveis. CONCLUSÕES: Espera-se que este artigo seja instrumento de atualização dos profissionais da Saúde, proporcionando atuação mais incisiva no processo de educação em saúde e nutrição. Torna-se urgente a adoção de práticas preventivas com esclarecimento aos pais e familiares cujos filhos participam ativamente da sociedade de consumo, visando minimizar os efeitos deletérios da ingestão rotineira de alimentos obesogênicos.

OBJECTIVE: To debate knowledge on labeling, packaging, releases and promotion of processed foods that have been included progressively in the diets of children and adolescents. DATA SOURCE: On-line articles from Medline and SciELO database published over the last ten years in Portuguese and English using the keywords "child", "marketing", "eating habits", "television", "health education". Also, books, recent texts and articles considered relevant for the present review were included. DATA SYNTHESIS: The present article discusses the food marketing according to propaganda, packaging and labeling. This review also approaches the influence of TV advertising on building of children and adolescents' eating habits; the nutrition quality of advertised foods and alternatives that parents and teachers could use to deal with these new patterns of consumption. Additionally, it is discussed packaging as a communication tool between manufacturer and consumer. Regarding labeling, the "Agência Nacional de Vigilância Sanitária" (Anvisa) new rules on Regulatory Nutritional Labeling as well as the importance of proper label reading for healthy choices are discussed. CONCLUSIONS: The present article is intended to be a tool for updating health professionals and encouraging them to act more effectively in health education and nutrition. It is urgent to adopt prevention practices enlightening parents and relatives whose children actively participate in the consumption society in order to minimize the harmful effects of the obesogenic foods routine ingestion.

53845 downloads Cited 6 times in SciELO

10.

Caracterização morfofisiológica de clones precoces e tardiosde batata visando à adaptação a condições tropicais
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Silva, Felipe Lopes da

; Pinto, César Augusto Brasil Pereira

; Alves, José Donizeti

; Benites, Flávio Rodrigo Gandolfi

; Andrade, Cristiana Moura

; Rodrigues, Gabriel Belfort

; Lepre, André Luiz

; Bhering, Leonardo Lopes

Bragantia

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2009, Volume 68 N. 2 Pages 295 - 302

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Os objetivos do trabalho foram avaliar os processos de crescimento, de tuberização e de partição de matéria seca em tubérculos de clones de batata precoces e tardios ao longo do ciclo vegetativo. Avaliou-se, ainda, a viabilidade do uso desses caracteres morfofisiológicos para a seleção de clones mais adaptados às condições tropicais. O trabalho foi desenvolvido em Lavras (MG), na safra das águas (agosto a dezembro de 2005). Os clones tardios foram mais produtivos que os precoces, devido ao crescimento mais vigoroso, à maior longevidade da área foliar fotossinteticamente ativa, à maior taxa de tuberização e ao período mais longo para enchimento de tubérculos. Os teores de clorofila a, b e total, a área foliar, a duração da área foliar, a taxa de crescimento relativo e a taxa assimilatória líquida para os tubérculos foram relevantes na diferenciação dos clones tardios e precoces. Sugere-se como estratégia possível para aumentar a produtividade da cultura da batata em regiões tropicais, a seleção de clones com ciclo vegetativo mais longo.

The objective of this research was to evaluate the growth, tuberization and dry matter partitioning to tubers of early and late potato clones during the vegetative growth. Besides, it was studied the viability for using morphophysiological traits as parameters to select clones more adapted to tropical conditions. The study was conducted in Lavras, Minas Gerais State, Brazil during the rainy season (August to December of 2005). Late clones were more productive than early clones at the end of the growth cycle, due to the more vigorous growth, longer duration of the photosynthetically active leaf area, the greater tuberization speed and the prolongation of tuber bulking period. Results also suggest that the morphophisiological traits used in this study are important to evaluate clones more adapted to the tropical conditions. The following physiological traits were relevant to differentiate late and early clones and should be used in breeding programs aimed at obtaining clones more adapted to the tropical conditions: content of chlorophylls a, b and total of the upper canopy, leaf area, leaf area duration, relative growth rate, and net assimilation rate to tubers. The results of this study suggest that one strategy that could be used to increase potato tuber yield in the tropics is the selection for a longer growth cycle.

2520 downloads Cited 9 times in SciELO

11.

Aceitabilidade de pão fortificado com ferro microencapsulado por crianças de creches das regiões sul e leste da cidade de São Paulo
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Souto, Teresinha Stumpf

; Brasil, Anne Lise Dias

; Taddei, José Augusto de Aguiar Carrazedo

Revista de Nutrição

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dec 2008, Volume 21 N. 6 Pages 647 - 657

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

OBJETIVO: Avaliar a aceitabilidade de um pão tipo bisnaguinha enriquecido com ferro microencapsulado por crianças freqüentadoras de creches, de acordo com sexo, faixa etária, estado nutricional, presença de anemia, tempo de estocagem e momento do experimento (inicial, meio e final). MÉTODOS: Ensaio clínico randomizado duplo-cego com 382 crianças de 2 a 6 anos de idade, matriculadas em quatro creches filantrópicas do município de São Paulo. As crianças de duas creches receberam no café da manhã, de segunda a sexta-feira, o pão fortificado com ferro microencapsulado e as das outras duas, pão idêntico, porém sem ferro, durante 120 dias. A ingestão foi anotada diariamente em planilhas individuais. Os testes estatísticos utilizados foram o qui-quadrado, o teste t de Student, a análise de variância e a análise de covariância. RESULTADOS: O consumo médio semanal de pães foi significantemente menor nas crianças das creches expostas (1,17) do que nas creches não expostas (1,56) e a variabilidade de aceitação foi maior nas creches não expostas. A ingestão foi significantemente menor pelas crianças das creches expostas em todas as variáveis estudadas, exceto nas faixas etárias menores de 36 meses e de 36 a 47 meses. CONCLUSÃO: Apesar de a aceitação pelas crianças do pão fortificado com ferro ter sido significantemente menor do que ao pão sem ferro, a aceitação nos dois grupos mostra que este pão pode ser alternativa viável para a fortificação de alimentos na prevenção da anemia ferropriva em crianças de creches.

OBJECTIVE: To evaluate the acceptance of a new food, a mini-roll enriched with microencapsulated iron sulfate, among preschool-aged children stratified by sex, age group, nutritional status, presence of iron-deficiency anemia, length of storage, and stage of trial (early, middle, late). METHODS: Double blind randomized clinical trial with 382 children aged 2 to 6 years enrolled in 4 not-for-profit daycare centers in the city of São Paulo, Brazil. Children in two daycare centers received the mini-rolls fortified with microencapsulated iron in breakfast from Monday to Friday (exposed daycare centers). Children in the other 2 daycare centers received regular, yet identical, mini-rolls in the same manner. Observation lasted 120 days. Acceptance was noted daily on specific log-sheets. Data were compared using the chi-square and Student's t tests, analysis of variance and analysis of covariance. RESULTS: Mean weekly consumption of mini-rolls was lower in exposed daycare centers (1.17) than in unexposed centers (1.54). Variance was greater in unexposed daycare centers. Acceptance was lower among children in exposed daycare centers in all stratified variable categories, except among children younger than 36 months or aged between 36 and 47 months. CONCLUSION: Although the children's acceptance of the rolls fortified with iron was significantly lower than that of rolls without iron fortification, this type of food might be a viable alternative in the prevention of iron-deficiency anemia in children of daycare centers.

3626 downloads Cited 2 times in SciELO

12.

Avaliação das condições higiênico-sanitárias das cozinhas de creches públicas e filantrópicas
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Oliveira, Mariana de Novaes

; Brasil, Anne Lise Dias

; Taddei, José Augusto de Aguiar Carrazedo

Ciência & Saúde Coletiva

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jun 2008, Volume 13 N. 3 Pages 1051 - 1060

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Este trabalho objetiva avaliar as condições higiênico-sanitárias das cozinhas de creches públicas e filantrópicas do município de São Paulo, através da utilização de um instrumento de fácil aplicação. As informações sobre as condições higiênico-sanitárias foram coletadas através da observação das condições de funcionamento da cozinha de cinco creches públicas e filantrópicas do município de São Paulo. Para a classificação do risco de contaminação da alimentação, foi criado um escore. As cozinhas observadas de creches públicas e filantrópicas do município de São Paulo encontram-se em condições de funcionamento que oferecem riscos de contaminação à alimentação produzida pela instituição. Dentre os maiores fatores de risco de contaminação dos alimentos encontram-se as ações dos manipuladores. O investimento em treinamento e supervisão continuada da mão-de-obra envolvida na manipulação de alimentos é a melhor e mais fácil alternativa a ser realizada como forma de garantia das adequadas condições higiênico-sanitárias e da qualidade da alimentação servida às crianças em creches.

This paper aims to evaluate the hygienic-sanitary conditions of kitchens in philanthropic and public daycare centers in the city of São Paulo using a tool of easy application. Information on the hygienic-sanitary conditions was gathered observing the operational conditions of five public and philanthropic daycare centers in the city of São Paulo. A score was developed for classifying the risks of food contamination. The operational conditions in the kitchens of the studied philanthropic and public daycare centers in the city of São Paulo can result in contamination of the prepared food. Among the most important risk factors for food contamination is the behavior of the workers who handle the food. Training and continuous supervision of the involved personnel are the best and easiest alternatives for assuring the appropriate hygienic-sanitary conditions and quality of the food offered to the children in these daycare centers.

13141 downloads Cited 16 times in SciELO

13.

Avaliação das condições higiênico-sanitárias das cozinhas de creches públicas e filantrópicas
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Oliveira, Mariana de Novaes

; Brasil, Anne Lise Dias

; Taddei, José Augusto de Aguiar Carrazedo

Ciência & Saúde Coletiva

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jun 2008, Volume 13 N. 3 Pages 1051 - 1060

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

23609 downloads Cited 16 times in SciELO

14.

Modelo experimental de indução de lesão oxidativa hepática em ratos por halotano
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Brasil, Luis Josino

; Amaral, José Luiz Gomes do

; Zettler, Claudio Galeano

; Marroni, Claudio Augusto

; Vercelino, Rafael

; Marroni, Norma

Arquivos de Gastroenterologia

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mar 2007, Volume 44 N. 1 Pages 73 - 77

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RACIONAL: O anestésico halotano pode ser metabolizado redutivamente a intermediários reativos que podem iniciar a lipoperoxidação acompanhada de injúria hepática. O tratamento prévio com hipóxia e fenobarbital em ratos aumenta o metabolismo do halotano e o estresse oxidativo e causa mudanças nas enzimas antioxidantes no fígado com dano hepático. MÉTODOS: Investigou-se o efeito do halotano na lipoperoxidação e histologia hepáticas após o aumento do metabolismo redutor do halotano induzido pela hipóxia e fenobarbital. Vinte e cinco ratos machos Wistar foram divididos em cinco grupos: Co (controle), HO14 (Halotano/Hipóxia), F (Fenobarbital), O14 (Hipóxia) e H (Halotano). Após 24 horas os ratos foram sacrificados, seus fígados foram retirados para determinar quimiluminescência, substâncias que reagem ao ácido tiobarbitúrico, enzimas antioxidantes, superóxido dismutase, catalase e amostras de sangue foram tomadas para determinar AST e a ALT. A avaliação histopatológica foi realizada pela técnica de hematoxilina-eosina. Os dados da avaliação histológica foram apresentados através de mediana e amplitude entre quartis. RESULTADOS E CONCLUSÕES: A exposição ao halotano/hipóxia causou lipoperoxidação hepática e mudanças significativas na atividade das enzimas antioxidantes. Além disso, provocou lesão histopatológica do fígado e aumento significativo dos níveis plasmáticos de AST e ALT.

BACKGROUND: The anesthetic halothane can be reductively metabolized to reactives intermediates that may initiate lipid peroxidation accompanied by hepatic injury. Hypoxia and phenobarbital pretreatment in rats increases metabolism of halothane, the oxidative stress, cause liver antioxidant enzymes changes and tissue damage. AIMS: We investigated the effect of halothane on hepatic lipid peroxidation and on hepatic histology after increases reductive metabolism of halothane caused by hypoxia and phenobarbital pretreatment. METHODS: Twenty-five male wistar rats were divided in five equals groups: CO (Control), HO14 (Halothane/Hypoxia), F (fenobarbital alone), O14 (Hypoxia alone) and H (Halothane alone). After 24 hours the rats were killed, their livers removed to determine chemoluminescence, thiobarbituric acid-reactive substances, catalase, superoxide dismutase, and blood samples were taken to determine AST and ALT. The histopathologic evaluation was performed with hematoxylin and eosin staining. Histopathologic scores are presented as 25th-75th percentile/range values and median ± range. RESULTS/CONCLUSION: Halothane-hypoxic exposure resulted in a significant changes in the activities of antioxidant enzymes, and induced hepatic lipoperoxidation. Moreover it resulted in histopathologic liver injury as well as significant increase of serum activity of AST and ALT.

2747 downloads Cited 1 time in SciELO

15.

Antropometria de escolares ao ingresso no ensino fundamental na cidade de Belém, Pará, 2001
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Neves, Olga Maria Domingues das

; Brasil, Anne Lise Dias

; Brasil, Laélia Maria Barra Feio

; Taddei, José Augusto de Aguiar Carrazedo

Revista Brasileira de Saúde Materno Infantil

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mar 2006, Volume 6 N. 1 Pages 39 - 46

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

OBJETIVOS: realizar a antropometria em escolares da primeira série da rede pública estadual em Belém, Pará, como instrumento de vigilância nutricional e estudar as associações entre o estado nutricional e características biológicas e socioeconômicas. MÉTODOS: foram avaliados nutricionalmente 793 escolares, pelos escores z de estatura/idade e peso/estatura, segundo a Organização Mundial da Saúde. As variáveis biológicas e socioeconômicas foram: sexo, idade, naturalidade, idade de ingresso da criança na escola e escolaridade materna. Utilizou-se o teste qui-quadrado ao relacionar o estado nutricional com as variáveis. RESULTADOS: em 637 escolares observamos 16,6% de baixa estatura e risco de baixa estatura, 4,5% de desnutrição e risco de desnutrição, 7,4% de sobrepeso e obesidade. Não houve associação significante entre estado nutricional e sexo. A maioria das crianças nasceu na capital, ingressou tardiamente na escola e tinham mães com escolaridade >4 anos. Observou-se correlação significante entre obesidade e baixa estatura com menor escolaridade materna; risco de desnutrição e baixa estatura com o ingresso escolar tardio; e obesidade e estatura normal com o ingresso regular. CONCLUSÕES: a menor escolaridade materna e o ingresso tardio escolar estão associados à presença de desvios nutricionais. A vigilância nutricional escolar é importante para avaliar, tratar e prevenir os riscos para saúde e nutrição infantil.

OBJECTIVES: to perform anthropometric measurements in elementary school students of the public school system of the State of Belém, Pará, as a tool for nutritional surveillance and to study associations between nutritional status and biological, social and economic characteristics. METHODS: 793 students were assessed for their nutritional status, by z scores of height/age and weight /height according to the World Health Organization criteria. Biological, social and economic variables were: gender, age, place of birth, age of school enrolment and maternal education level. The chi square test was used to relate nutritional status to variables. RESULTS: of the 637 students assessed, 16.6% were of low stature or in risk of low stature, 4.5% malnourished or in risk of malnourishment, 7.4% were overweight or obese. There was no significant association between nutritional status and gender. The majority of the children was born in the capital, was enrolled late in school and had mothers with education level of >4 years. There was a significant correlation between obesity and low stature with low maternal education level; malnutrition risk and low stature with late school enrolment; and obesity and normal stature with regular enrollment. CONCLUSIONS: low maternal school level and late school enrollment are associated to nutritional problems. School nutritional surveillance is important to assess, treat and prevent children's health and nutrition risks.

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