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Abstract This publication is an update of the “Consensus on the therapeutic management of atopic dermatitis - Brazilian Society of Dermatology” published in 2019, considering the novel, targeted-oriented systemic therapies for atopic dermatitis. The initial recommendations of the current consensus for systemic treatment of patients with atopic dermatitis were based on a recent review of scientific published data and a consensus was reached after voting. The Brazilian Society of Dermatology invited 31 experts from all regions of Brazil and 2 international experts on atopic dermatitis who fully contributed to the process. The methods included an e-Delphi study to avoid bias, a literature search and a final consensus meeting. The authors added novel approved drugs in Brazil and the indication for phototherapy and systemic therapy for AD. The therapeutical response to systemic treatment is hereby reported in a suitable form for clinical practice and is also part of this updated manuscript.

https://doi.org/10.1016/j.abd.2023.04.003

Skin manifestations associated with systemic diseases – Part I,
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Sampaio, Ana Luisa

; Bressan, Aline Lopes

; Vasconcelos, Barbara Nader

; Gripp, Alexandre Carlos

Anais Brasileiros de Dermatologia

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dec 2021, Volume 96 N. 6 Pages 655 - 671

Abstract: En | Text: En | PDF: En

Abstract The skin demonstrates what is happening in the body in many diseases, as it reflects some internal processes on the surface. In this sense, skin as an organ, goes beyond its protective and barrier functions, as it provides clues for the identification of some systemic diseases. The dermatologist then raises diagnostic hypotheses for conditions related to all systems and refers them to the appropriate specialty. With easy access to examination by trained eyes and biopsies, the skin can present specific or non specific alterations on histopathology. In the first case this combination establishes the diagnosis of the disease itself. Non specific manifestations can occur in a variety of contexts and then histopathology is not specific of a particular disease. This article is divided into two parts that will cover large groups of diseases. In this first part, cutaneous manifestations of the main rheumatologic diseases are described, which are the ones with the greatest interface with dermatology. The authors also talk about vascular manifestations and granulomatous diseases. In the second part, endocrinological, hematological, oncological, cardiovascular, renal, gastrointestinal diseases, pruritus and its causes are discussed, and finally, the dermatological manifestations of SARS-CoV-2 coronavirus infection. The authors’ intention is that, by using direct and easily accessible language, aim to provide practical material for consultation and improvement to all dermatologists who recognize the importance of a comprehensive assessment of their patients.

https://doi.org/10.1016/j.abd.2021.02.008

Consumo de bebidas alcoólicas e excesso de peso em adultos brasileiros - Projeto CUME
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Souza, Luís Paulo Souza e

; Hermsdorff, Helen Hermana Miranda

; Miranda, Aline Elizabeth da Silva

; Bressan, Josefina

; Pimenta, Adriano Marçal

Ciência & Saúde Coletiva

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oct 2021, Volume 26 Suppl. 3 Pages 4835 - 4848

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Estudo transversal com 2.909 participantes (≥ 18 anos) da linha de base da Coorte de Universidades Mineiras (CUME), Brasil, que verificou a associação entre o consumo de bebidas alcoólicas e o excesso de peso. Por meio de questionário virtual, coletaram-se dados sociodemográficos, de estilo de vida, hábitos alimentares, antropométricos e condições clínicas. Considerou-se Índice de Massa Corporal ≥ 25 kg/m2 como excesso de peso. Avaliou-se o consumo diário de bebidas alcoólicas no total em gramas (álcool) e segundo tipo em mililitros (cerveja, vinhos e destiladas). As prevalências de consumo de álcool e excesso de peso foram 73,6% e 40,8%, respectivamente. Houve uma tendência significativa de aumento da prevalência de excesso de peso quanto maior o consumo de cerveja (p de tendência = 0,038), fato não observado para os demais tipos de bebidas. Após análises de sensibilidade, a ingestão de álcool associou-se ao excesso de peso, com tendência de aumento da prevalência quanto maior o consumo diário. Ressalta-se a necessidade de reduzir a visão amplamente aceita de que o consumo leve a moderado de álcool não é nocivo à saúde, adotando cautela nesta proposição. Deve-se considerar a influência da ingestão de bebidas alcoólicas no ganho de peso nas políticas públicas de saúde e de controle do consumo do álcool.

Abstract This is a cross-sectional study with 2,909 participants (aged ≥18 years) from the baseline of the Cohort of Universities of Minas Gerais [CUME - Coorte de Universidades Mineiras] which verified the association between alcohol consumption and overweight. Data on sociodemographic factors, lifestyle, eating habits, anthropometric factors and clinical conditions were collected through an online questionnaire. Body mass index ≥ 25 kg/m² was considered an indicator of overweight. The daily consumption of alcohol was evaluated in grams (alcohol) and according to type in milliliters (beer, wine, hard liquor). The prevalence of alcohol consumption and overweight was 73.6% and 40.8%, respectively. There was a significant tendency of an increase in overweight with higher beer consumption (tendency p value of 0.038), which was not observed for the other types of alcohol. After sensitivity analyses, alcohol consumption was associated to overweight, with a tendency of increase in prevalence with higher daily consumption. There is a crucial need to curb the widely accepted idea that a low or moderate alcohol consumption is not harmful to one’s health, and to be cautious of such a proposition. The influence of alcohol consumption regarding weight gain must be considered in public health policies and policies of alcohol consumption control.

https://doi.org/10.1590/1413-812320212611.3.20192019 1 downloads

Consumo de bebidas alcoólicas e excesso de peso em adultos brasileiros - Projeto CUME
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Souza, Luís Paulo Souza e

; Hermsdorff, Helen Hermana Miranda

; Miranda, Aline Elizabeth da Silva

; Bressan, Josefina

; Pimenta, Adriano Marçal

Ciência & Saúde Coletiva

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oct 2021, Volume 26 Suppl. 3 Pages 4835 - 4848

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1413-812320212611.3.20192019

Alopecia areata-like and psoriasis after dupilumab use for atopic dermatitis,
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Maiolini, Viviane Maria

; Sousa, Nathalie Andrade

; Marsillac, Paula Figueiredo de

; Bressan, Aline Lopes

Anais Brasileiros de Dermatologia

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oct 2021, Volume 96 N. 5 Pages 634 - 636

Abstract: En | Text: En | PDF: En

https://doi.org/10.1016/j.abd.2021.03.005 24 downloads

Analysis of the Correlation Between Serum Vitamin D Levels and Severity of Atopic Dermatitis
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Mariz, Juliana Câmara

; Barros, Norami de Moura

; Martins, Bárbara de Oliveira

; Bressan, Aline Lopes

Revista da Sociedade Portuguesa de Dermatologia e Venereologia

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mar 2021, Volume 79 N. 1 Pages 26 - 29

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Introdução: A dermatite atópica (DA) é uma doença inflamatória crônica e multifatorial. Casos graves afetam a qualidade de vida. A patogénese é complexa, marcada por resposta imune celular defeituosa, exacerbação da resposta inflamatória Th2 e comprometimento da função de barreira da pele. Evidências sugerem que a vitamina D atua na regulação da resposta imune inata e adaptativa, na redução do processo inflamatório e na melhora da barreira cutânea. O nosso objectivo foi correlacionar os níveis séricos de vitamina D com a gravidade da DA. Material e Métodos: Foram analisados prontuários de 30 pacientes assistidos em um ambulatório de Dermatologia, entre 2015 e 2018. Os pacientes foram divididos em 2 grupos: doença leve (terapia tópica) e doença moderada a grave (usuários de imunossupressores). Resultados: Foram selecionados 10 casos com DA leve e 20 com DA moderada a grave. Entre os pacientes com doença leve, 20% apresentaram deficiência de vitamina D. Quanto aos pacientes com doença moderada a grave, 40% apresentaram vitamina D deficiente. Comparando a média de vitamina D nos dois grupos, não houve diferença estatística entre o valor médio. Conclusão: Estudos sobre associação entre os níveis de vitamina D e gravidade da DA permanecem controversos. Alguns trabalhos reforçam essa associação. Neste estudo, apesar da proporção de pacientes com deficiência de vitamina D ser duas vezes maior entre os pacientes com DA moderada a grave, não houve significância estatística entre os dois grupos, corroborando estudos já publicados. Mais estudos relacionando a dermatite atópica à vitamina D são desejáveis, tendo em vista a sua possível aplicabilidade como terapêutica auxiliar.

ABSTRACT Introduction: Atopic dermatitis (AD) is a chronic inflammatory multifactorial disease. Severe cases affect the quality of life. The pathogenesis is complex, marked by defective cellular immune system, exacerbation of Th2-type immune response and impaired skin barrier function. Studies suggest that vitamin D acts in the regulation of the innate and adaptive immune response, reduces the inflammatory process and improves the skin barrier. Our objective was to correlate vitamin D serum levels with the severity of AD. Material and Methods: Between 2015 and 2018 the authors evaluated 30 patients aged between 18 and 90 years old, under treatment at a Dermatology ambulatory clinic. Patients were divided into 2 groups: mild disease (only topical therapy) and moderate to severe disease (under immunosuppressive treatment). Results: Ten cases with mild AD and 20 with moderate to severe AD were selected. Among patients with mild disease, 20% had vitamin D deficiency. As for patients with moderate to severe disease, 40% had a deficient serum level of 25-hydroxyvitamin D. Comparing the average vitamin D in the two groups, there was no statistical difference between them. Conclusion: In the literature, the association between vitamin D levels and the severity of AD remain controversial, although some studies support this association. In this study, despite the proportion of patients with 25-hydroxyvitamin D deficiency being twice as high among patients with moderate to severe AD, there was no statistical significance between the groups, corroborating previous manuscripts. Clinical studies relating atopic dermatitis to vitamin D are warranted, considering its possible use as a concomitant therapy.

https://doi.org/10.29021/spdv.79.1.1287 15 downloads

Binge drinking and overweight in brazilian adults - CUME Project
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Souza e Souza, Luís Paulo

; Miranda, Aline Elizabeth da Silva

; Hermsdorff, Helen Hermana Miranda

; Silva, Carla Silvana de Oliveira e

; Barbosa, Dulce Aparecida

; Bressan, Josefina

; Pimenta, Adriano Marçal

Revista Brasileira de Enfermagem

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2020, Volume 73 elocation e20190316

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivo: Verificar associação entre consumo pesado episódico de álcool [binge drinking (BD)] e excesso de peso em 2.909 adultos da linha de base da Coorte de Universidades Mineiras (CUME), Brasil. Método: Estudo transversal no qual se coletaram dados sociodemográficos, antropométricos (IMC ≥ 25 kg/m2 = excesso de peso) e alimentares. Avaliaram-se presença e frequência mensal do BD (≥4 doses em única ocasião para mulheres; ≥5 doses para homens, nos últimos 30 dias). Resultados: As prevalências do BD e excesso de peso foram 41,3% e 40,8%, respectivamente. O BD aumentou em 19% a prevalência do excesso de peso, e a exposição ao BD em ≥5 dias/mês aumentou em 31%. Conclusão: O BD em única ou em várias ocasiões no mês se associou à maior prevalência de excesso de peso. Portanto, tal hábito de vida deve ser considerado nas estratégias de prevenção do ganho de peso.

ABSTRACT Objective: To verify the association between heavy episodic alcohol consumption [binge drinking (BD)] and overweight in 2,909 adults from the Cohort of Universities of Minas Gerais (CUME Project) baseline, Brazil. Method: Cross-sectional study in which sociodemographic, anthropometric (BMI ≥ 25 kg/m2 = overweight) and dietary intake data were collected. This study evaluated the occurrence and monthly frequency of BD (≥ 4 drinks at one time for women; ≥ 5 drinks at one time for men, in the last 30 days). Results: The prevalence of BD and overweight were 41.3% and 40.8%, respectively. BD increased the prevalence of overweight by 19%, and, BD exposure by ≥ 5 days / month increased it by 31%. Conclusion: BD on a single or multiple occasion during the month was associated with a higher prevalence of overweight. Therefore, such a lifestyle should be considered in weight gain prevention strategies.

RESUMEN Objetivo: Verificar la relación entre el episodio de exceso de alcohol [binge drinking (BD)] y el sobrepeso en 2.909 adultos de la línea de base de la Coorte de Universidades Mineiras (CUME), Brasil. Método: Estudio transversal en lo cual se recogieron datos sociodemográficos, antropométricos (IMC ≥ 25 kg/m2 = sobrepeso) y alimentares. Se evaluaron presencia y frecuencia mensual del BD (≥ 4 dosis en única ocasión para mujeres; ≥ 5 dosis para hombres, en los últimos 30 días). Resultados: Las prevalencias del BD y sobrepeso han sido 41,3% y 40,8%, respectivamente. BD ha aumentado en 19% la prevalencia del sobrepeso, y la exposición al BD en ≥ 5 días/mes ha aumentado en 31%. Conclusión: El BD en única o en varias ocasiones en el mes se relacionó a la mayor prevalencia de sobrepeso. Así que, tal hábito de vida debe ser considerado en las estrategias de prevención del aumento de peso.

https://doi.org/10.1590/0034-7167-2019-0316 973 downloads

Binge drinking and overweight in brazilian adults - CUME Project
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Souza e Souza, Luís Paulo

; Miranda, Aline Elizabeth da Silva

; Hermsdorff, Helen Hermana Miranda

; Silva, Carla Silvana de Oliveira e

; Barbosa, Dulce Aparecida

; Bressan, Josefina

; Pimenta, Adriano Marçal

Revista Brasileira de Enfermagem

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2020, Volume 73 Suppl. 1 elocation e20190316

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

https://doi.org/10.1590/0034-7167-2019-0316 5 downloads

Diagnostic and therapeutic guidelines for plaque psoriasis - Brazilian Society of Dermatology
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Arnone, Marcelo

; Takahashi, Maria Denise Fonseca

; Carvalho, André Vicente Esteves de

; Bernardo, Wanderley Marques

; Bressan, Aline Lopes

; Ramos, Andrea Machado Coelho

; Terena, Aripuanã Cobério

; Souza, Cacilda da Silva

; Nunes, Daniel Holthausen

; Bortoletto, Maria Cecília de Carvalho

; Oliveira, Maria de Fátima Santos Paim de

; Neffá, Jane Marcy

; Fieri, Luciana Cristina

; Azulay-Abulafia, Luna

; Felix, Paulo Antônio Oldani

; Magalhaes, Renata Ferreira

; Romiti, Ricardo

; Jaime, Tatiana Jerez

Anais Brasileiros de Dermatologia

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apr 2019, Volume 94 N. 2 Pages 76 - 107

Abstract: En | Text: En | PDF: En

Abstract: Psoriasis is a chronic inflammatory disease that affects 1.3% of the Brazilian population. The most common clinical manifestations are erythematous, scaling lesions that affect both genders and can occur on any anatomical site, preferentially involving the knees, elbows, scalp and genitals. Besides the impact on the quality of life, the systemic nature of the disease makes psoriasis an independent risk factor for cardiovascular disease, especially in young patients with severe disease. By an initiative of the Brazilian Society of Dermatology, dermatologists with renowned clinical experience in the management of psoriasis were invited to form a work group that, in a partnership with the Brazilian Medical Association, dedicated themselves to create the Plaque Psoriasis Diagnostic and Treatment Guidelines. The relevant issues for the diagnosis (evaluation of severity and comorbidities) and treatment of plaque psoriasis were defined. The issues generated a search strategy in the Medline-PubMed database up to July 2018. Subsequently, the answers to the questions of the recommendations were devised, and each reference selected presented the respective level of recommendation and strength of scientific evidence. The final recommendations for making up the final text were worded by the coordinators.

https://doi.org/10.1590/abd1806-4841.2019940211 3381 downloads

10.

How relevant are vascular endothelial growth factor and intercellular adhesion molecule in the systemic capillary leak syndrome of psoriasis?
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Bressan, Aline Lopes

; Pereira, Daniele

; Medeiros, Paula Mota

; Carneiro, Sueli

; Azulay-Abulafia, Luna

Anais Brasileiros de Dermatologia

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dec 2017, Volume 92 N. 6 Pages 826 - 829

Abstract: En | Text: En | PDF: En

Abstract: Psoriasis is a chronic disease, characterized by erythematous scaly lesions, presented in eight different forms: plaques, guttate, pustular, erythrodermic, inverse, nail and scalp psoriasis, and psoriatic arthritis. Its development depends on genetic factors, external stimulus and immune response alteration.1 Proinflammatory cytokines such as TNF-alpha, IL-12 and 23 may also be involved. In the worst cases, systemic complications linked to endothelial alterations may occur. A literature review was conducted for a better understanding of what roles VEGF (vascular endothelial growth factor) and ICAM-1 (intercellular adhesion molecule) have, among other cytokines, in systemic capillary leak syndrome, involved in erythrodermic and pustular psoriasis, the most unstable forms of the disease.

https://doi.org/10.1590/abd1806-4841.20175994 905 downloads

11.

VALIDAÇÃO DA SÍNDROME METABÓLICA E DE SEUS COMPONENTES AUTODECLARADOS NO ESTUDO CUME
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Miranda, Aline Elizabeth da Silva

; Ferreira, Adaliene Versiani Matos

; Oliveira, Fernando Luiz Pereira de

; Hermsdorff, Helen Hermana Miranda

; Bressan, Josefina

; Pimenta, Adriano Marçal

Reme: Revista Mineira de Enfermagem

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2017, Volume 21 elocation e-1069

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

ABSTRACT The aim of this study was to analyze the validity of self-reported diagnoses of metabolic syndrome (MetS) and its components through participants of the Cohort of Universities of Minas Gerais (CUME). A subsample of 172 cohort participants (33 males and 139 females, age 38 ± 11 years) was randomly selected for this study. The presence of MetS was defined according to the criteria of the International Diabetes Federation (IDF). Data on weight, height, blood pressure, and serum concentration of glucose, triglycerides and HDL-c were self reported in an online cohort questionnaire, and the same variables were measured using a standardized protocol in laboratories of higher education institutions involved in the project. Self-reported and measured data were compared by means of intraclass correlation coefficient (ICC), Kappa coefficient (k) and differences between self-reported and measured data, according to the Bland and Altman method. The prevalence of MetS was 4.7% and 5.2% according to self-reported and measured data, respectively. The Kappa coefficient between diagnoses of self-reported and measured MetS was 0.814, indicating almost perfect agreement, a situation similar to that observed for obesity (k = 0.882). The other components of MetS had moderate agreement (k = 0.41 to 0.60). The ICC also indicated excellent agreement for weight, height, BMI and HDL-c, respectively, 0.989, 0.995, 0.983 and 0.761. Glucose presented low agreement (ICC: 0.366). The study concludes that the CUME project participants provided valid information for the self-reported diagnoses of MetS and its components.

RESUMEN El objetivo de este estudio fue analizar la validez de los diagnósticos autodeclarados de síndrome metabólico (SM) y de sus componentes por los participantes de la Cohorte de Universidades Mineras (CUME). Para este estudio fue aleatoriamente seleccionada una submuestra de 172 participantes de la cohorte (33 hombres y 139 mujeres, edad 38 ± 11 años). La presencia de SM fue definida según los criterios de la International Diabetes Federation (IDF). Los datos de peso, altura, presión arterial, concentración sérica de glucosa, triglicéridos y HDL-c fueron autodeclarados en un cuestionario en línea de la cohorte y las mismas variables fueron evaluadas presencialmente mediante un protocolo estandarizado en laboratorios de las instituciones de enseñanza superior involucradas en el proyecto. Los datos autodeclarados y evaluados se compararon mediante el coeficiente de correlación intraclase (CCI), el coeficiente Kappa (k) y las diferencias entre medidas autodeclaradas y evaluadas según la metodología de Bland y Altman. Las prevalencias de la SM fueron del 4,7% y del 5,2% de acuerdo con los datos autodeclarados y evaluados, respectivamente. El coeficiente Kappa entre diagnósticos de SM autodeclarado y constatado fue 0,814, indicando concordancia casi perfecta, situación similar a la observada para la obesidad (k = 0,882). Los demás componentes de SM presentaron concordancias moderadas (k = 0,41 a 0,60). Los CCI también indicaron una excelente concordancia para peso, estatura, IMC y HDL-c, respectivamente, 0,989, 0,995, 0,983 y 0,761. La glucosa presentó baja concordancia (CCI: 0,336). Se concluye que los participantes del proyecto CUME proporcionaron información válida para los diagnósticos autodeclarados de SM y sus componentes.

RESUMO O objetivo deste estudo foi analisar a validade dos diagnósticos autodeclarados de síndrome metabólica (SM) e de seus componentes pelos participantes da Coorte de Universidades Mineiras (CUME). Uma subamostra de 172 participantes da coorte (33 homens e 139 mulheres, idade 38 ± 11 anos) foi aleatoriamente selecionada para este estudo. A presença de SM foi definida segundo os critérios da International Diabetes Federation (IDF). Dados de peso, altura, pressão arterial, concentração sérica de glicose, triglicerídeos e HDL-c foram autodeclarados em questionário online da coorte e as mesmas variáveis foram aferidas presencialmente mediante protocolo padronizado em laboratórios das instituições de ensino superior envolvidas no projeto. Os dados autodeclarados e aferidos foram comparados por meio de coeficiente de correlação intraclasse (CCI), coeficiente Kappa (k) e diferenças entre medidas autodeclaradas e aferidas segundo a metodologia de Bland e Altman. As prevalências da SM foram de 4,7%e 5,2%, de acordo com os dados autodeclarados e aferidos, respectivamente. O coeficiente Kappa entre diagnósticos de SM autodeclarado e aferido foi 0,814, indicando concordância quase perfeita, situação similar à observada para a obesidade (k=0,882). Os demais componentes da SM apresentaram concordâncias moderadas (k=0,41 a 0,60). Os CCIs também indicaram excelente concordância para peso, estatura, IMC e HDL-c, respectivamente, 0,989, 0,995, 0,983 e 0,761. A glicose apresentou baixa concordância (CCI: 0,336). Concluiu-se que participantes do projeto CUME forneceram informações válidas para os diagnósticos autodeclarados de SM e de seus componentes.

https://doi.org/10.5935/1415-2762.20170079 5 downloads

12.

Lichen sclerosus associated with localized scleroderma: dermoscopy contribution
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Nóbrega, Monisa Martins

; Cabral, Fernanda

; Corrêa, Mariana César

; Barcaui, Carlos Baptista

; Bressan, Aline Lopes

; Gripp, Alexandre Carlos

Anais Brasileiros de Dermatologia

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aug 2016, Volume 91 N. 4 Pages 534 - 536

Abstract: En | Text: En | PDF: En

Abstract: Lichen sclerosus is an uncommon inflammatory dermatosis with preferential involvement of the urogenital region. The extragenital involvement is uncommon and is characterized by small rounded macules or papules, pearly white in color. The coexistence of lichen sclerosus and scleroderma plaques in most cases with extragenital location has been reported in the literature. We report a case of lichen sclerosus associated with scleroderma in children, highlighting the importance of dermoscopy in diagnosis.

https://doi.org/10.1590/abd1806-4841.20164813 2401 downloads

13.

Rabbit olfactory stem cells. Isolation protocol and characterization
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Ercolin, Anna Carolina Mazeto

; Roballo, Kelly Cristine Santos

; Casals, Juliana Barbosa

; Pieri, Naira Caroline Godoy

; Souza, Aline Fernanda

; Barreto, Rodrigo da Silva Nunes

; Bressan, Fabiana Fernandes

; Feitosa, Matheus Levi Tajra

; Miglino, Maria Angélica

; Meirelles, Flávio Vieira

; Ambrósio, Carlos Eduardo

Acta Cirúrgica Brasileira

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jan 2016, Volume 31 N. 1 Pages 59 - 66

Abstract: En | Text: En | PDF: En

PURPOSE: To describe a new technique for isolation of a mesenchymal stem cells (MSCs) population from the olfactory mucosa in rabbits. METHODS: Olfactory stem cells (OSCs) were retrieved from under the cribriform plate of the Ethmoid bone. Several assays were accomplished to characterize the cell population and attest its viability in vitro. The cells were submitted to flow cytometry with the antibodies CD34, CD45, CD73, CD79, CD90 and CD105 and also they were induced to differentiate in three lineages. Functional evaluation involved analysis of in vitro growth behavior, colony forming unit like fibroblasts (CFU-f) and cryopreservation response. Further transduction with Green Fluorescent Protein (GFP) was also performed. RESULTS: The OSCs showed mesenchymal features, as positive response to CD34, CD73 and CD90 antibodies and plasticity. Additionally, these cells have high proliferated rate, and they could be cultured through many passages and kept the ability to proliferate and differentiate after cryopreservation. The positive response to the transduction signalizes the possibility of cellular tracking in vivo. This is a desirable feature in case those cells are used for pre-clinical trials. CONCLUSION: The cells harvested were mesenchymal stem cells and the technique described is therefore efficient for rabbit olfactory stem cells isolation.

https://doi.org/10.1590/S0102-865020160010000009 2346 downloads

14.

Bullous pemphigoid and neurological disease: statistics from a dermatology service
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Tarazona, Monica Jidid Mateus

; Mota, Amanda Nascimento Cavalleiro de Macedo

; Gripp, Alexandre Carlos

; Unterstell, Natasha

; Bressan, Aline Lopes

Anais Brasileiros de Dermatologia

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apr 2015, Volume 90 N. 2 Pages 280 - 282

Abstract: En | Text: En | PDF: En

Bullous pemphigoid (BP) is an autoimmune, acquired, cutaneous disease caused by the production of autoantibodies against hemidesmosomes' components in the basement membrane. The estimated incidence in Europe ranges from 7 to 43 cases per million inhabitants per year. Several studies have reported an association between BP and neurological disorders (ND). Our cohort of Bullous pemphigoid and ND is the first in Brazil and showed a significantly high prevalence of neurological and/or psychiatric diseases, especially cerebrovascular accident (CVA) and dementia, in agreement with the prevalence reported in several studies published in the medical literature in recent years.

https://doi.org/10.1590/abd1806-4841.20153334 1963 downloads

15.

Systemic sarcoidosis induced by etanercept: first Brazilian case report
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Unterstell, Natasha

; Bressan, Aline Lopes

; Serpa, Laura Araújo

; Castro, Pérola Peres da Fonseca e

; Gripp, Alexandre Carlos

Anais Brasileiros de Dermatologia

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dec 2013, Volume 88 N. 6 Pages 197 - 199

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Os medicamentos antagonistas do fator de necrose tumoral alfa (TNF-α) estão sendo cada vez mais utilizados no tratamento de doenças inflamatórias e autoimunes. Efeitos adversos desses medicamentos vem sendo relatados, incluindo o desenvolvimento paradoxal de sarcoidose, principalmente com o uso do etanercepte. Apresentamos o primeiro relato de caso brasileiro de sarcoidose sistêmica induzida por etanercepte e uma revisão da literatura.

The antagonists of tumor necrosis factor alpha (TNF-α) are increasingly being used in the treatment of inflammatory and autoimmune diseases. Several adverse effects of these drugs have been reported, including the paradoxical development of sarcoidosis, especially with the use of etanercept. We present the first Brazilian case report of systemic sarcoidosis induced by etanercept and a literature review.

https://doi.org/10.1590/abd1806-4841.20132588 1935 downloads

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