Abstract Sugammadex is a distinctive neuromuscular reversal drug that acts by encapsulating the neuromuscular relaxant molecule and dislodging it from its site of action. Sugammadex has been approved for pediatric patients over 2 years of age. Although arrhythmias have been reported, there is no report of adverse effects in healthy children, such as severe bradycardia requiring intervention. We report two cases of severe bradycardia immediately after the administration of sugammadex in healthy children. Our aim is to alert to the occurrence of one of the most severe adverse effects of sugammadex, in the healthy pediatric population as well.

Resumo Introdução: O Comprometimento Cognitivo Leve (CCL) é caracterizado pela presença de queixas subjetivas de memória, sendo considerado um estágio entre a função cognitiva normal e a patológica. O declínio das funções cognitivas pode estar relacionado ao baixo desempenho funcional e a alteração da composição corporal em idosos. Objetivo: Avaliar a força muscular, o desempenho funcional de membros inferiores e a composição corporal de idosas com CCL. Métodos: participaram do estudo 43 idosas que foram divididas em 2 grupos, sendo 19 idosas com CCL e 24 idosas sem CCL, a idade variou de 60 a 80 anos. Para diagnóstico do CCL utilizou-se os instrumentos propostos por Petersenet al, no qual a idosa deveria apresentar queixas de memória, sem repercussões nas atividades básicas e instrumentais de vida diária.A força muscular foi avaliada pela força de preensão palmar (FPP) utilizando o dinamômetro (Jamar®) e a força extensora do joelho (FEJ) pelo movimento de 1 repetição máxima (1-RM). O desempenho funcional de membros inferiores (MMII) foi avaliado pelo instrumento Short Physical Performance Battery (SPPB) e a composição corporal pela ImpedânciaBioelétrica (Biodynamics Model 310). Resultados: Foi encontrada diferença significativa na força muscular entre os grupos, sendo que o grupo de idosas com CCL apresentou menor FPP (p = 0,002) e menor FEJ (p = 0,002). As demais variáveis como SPPB e a composição corporal não apresentaram diferença significativa entre os grupos. Quanto às correlações, obteve-se correlação positiva significativa entre o SPPB e a FEJ (r = 0,55; p = 0,0001), o SPPB e a FPP (r = 0,37; p = 0,0155), a FEJ e a FPP (r = 0,59; p < 0,0001), e entre a massa magra e a FPP (r = 0,36; p = 0,0184). Conclusão: A força muscular dos MMII e a FPP estão diminuídas nas idosas com CCL, diferentemente do desempenho funcional de MMII e da composição corporal que não foram diferentes entre os grupos.

Abstract Introduction: Mild cognitive impairment (MCI) is characterized by subjective memory complaints and is considered an intermediate stage between normal and pathological cognitive function. The decline in cognitive function may be associated with low functional performance and alterations in body composition in older adults. Objective: To assess muscle strength, lower extremity functional performance and body composition in elderly women with MCI. Methods: Forty-three elderly women (aged 60-80 years) participated in the study. Participants were divided into two groups: elderly women with MCI (n = 19) and elderly women without MCI (n = 24). To diagnose MCI, we used the instruments proposed by Petersen et al. According to it, the subjects had to have memory complaints that had no effects on basic or instrumental activities of daily living. Muscle strength was assessed via palmar grip strength (PGS) using a dynamometer (Jamar®) and knee extension strength (KES) was assessed using the one-repetition maximum test (1-RM). Lower extremity (LE) functional performance was assessed using the Short Physical Performance Battery (SPPB) and body composition was measured using biometrical impedance analysis (Biodynamics Model 310). Results: There was a significant difference in muscle strength between groups. The group with MCI had lower PGS (p = 0.002) and KES (p = 0.002), when compared to their counterparts. No significant difference between groups was found for the other variables, like SPPB and body composition. We found a positive, significant correlation between SPPB and KES (r = 0.55; p = 0.0001), SPPB and PGS (r = 0.37; p = 0.0155), KES and PGS (r = 0.59; p < 0.0001), and between lean mass and PGS (r = 0.36; p = 0.0184). Conclusion: Elderly women with MCI show reduced LE muscle strength and PGS, but no differences between groups were found for LE functional performance and body composition.