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au:CAMARGOS, M. F.

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Constant testing for Pestivirus in cell lines reveals different routes of contamination
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OLIVEIRA, TATIANA F.P. DE

; A.F. JÚNIOR, ANTÔNIO

; OLIVEIRA, ANAPOLINO M. DE

; CAMARGOS, MARCELO F.

; HEINEMANN, MARCOS B.

Anais da Academia Brasileira de Ciências

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2023, Volume 95 N. 1 elocation e20220309

Abstract: En | Text: En | PDF: En

Abstract Pestivirus can contaminate cell cultures and sera and cause serious problems that evolve the integrity of studies, confidence in diagnostic results, and safety of human and animal vaccines. Contaminations by Pestivirus and other viruses may occur at any time and regular assays of monitoring in cell cultures and your supplies are necessary. This study aimed to analyze the phylogeny of Pestivirus detected from cell cultures, calf serum, and standard strains of three laboratories in Brazil that carry out frequent tests for the monitoring of cellular contaminations. These samples were submitted to phylogenetic analysis to understand the genetic relationship between contaminants occurring in these facilities. As result, the Pestivirus found in samples were Bovine viral diarrhea virus (BVDV-1 and BVDV-2), Hobi-like viruses (often named BVDV-3), and Classical swine fever virus (CSFV), and the phylogenetic analysis help us to infer at three possible routes of contamination in this work.

https://doi.org/10.1590/0001-37652023202200309

Genetics of Parkinson’s disease in Brazil: a systematic review of monogenic forms
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Santos-Lobato, Bruno L.

; Schumacher-Schuh, Artur

; Mata, Ignacio F.

; Letro, Grace H.

; Braga-Neto, Pedro

; Brandão, Pedro R. P.

; Godeiro-Junior, Clécio O.

; Coletta, Marcus V. Della

; Camargos, Sarah T.

; Borges, Vanderci

; Rieder, Carlos R. M.

; Tumas, Vitor

Arquivos de Neuro-Psiquiatria

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jul 2021, Volume 79 N. 7 Pages 612 - 623

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Introdução: Um número crescente de mutações causando formas monogênicas de doença de Parkinson (DP) tem sido descrito, principalmente entre pacientes da Europa e da América do Norte. Como a arquitetura genética varia entre diferentes populações, entender os perfis genéticos específicos de pacientes brasileiros é essencial para um melhor aconselhamento genético e para a seleção de participantes para ensaios clínicos. Objetivo: Revisão sistemática para identificar estudos genéticos brasileiros na área e definir o cenário para estudos futuros das formas monogênicas de DP no Brasil. Métodos: Nós pesquisamos as bases de dados MEDLINE, EMBASE e Web of Science desde a criação até dezembro de 2019, usando termos para “Parkinson’s disease”, “genetics” e “Brazil”. A extração de dados foi feita por dois revisores independentes. Para os genes LRRK2 e PRKN, calculamos a prevalência estimada para cada estudo e realizamos uma meta-análise. Resultados: Um total de 32 estudos foram incluídos e 94 pacientes brasileiros com DP com mutações causativas foram identificados em 2872 pacientes avaliados (3.2%). As mutações no PRKN causaram DP em 48 de 576 pacientes (8.3%). As mutações no LRRK2 foram identificadas em 40 de 1566 pacientes (2.5%), sendo a mutação mais comum a p.G2019S (2.2%). Conclusões: As mutações na PRKN são a causa mais comum de DP autossômica recessiva, e as mutações no LRRK2 a causa mais comum de DP autossômica dominante. Nós observamos uma falta de estudos epidemiológicos robustos em genética de DP, especialmente por não levar em conta a diversidade de nossa população.

ABSTRACT Background: Increasing numbers of mutations causing monogenic forms of Parkinson's disease (PD) have been described, mostly among patients in Europe and North America. Since genetic architecture varies between different populations, studying the specific genetic profile of Brazilian patients is essential for improving genetic counseling and for selecting patients for clinical trials. Objective: We conducted a systematic review to identify genetic studies on Brazilian patients and to set a background for future studies on monogenic forms of PD in Brazil. Methods: We searched MEDLINE, EMBASE and Web of Science from inception to December 2019 using terms for "Parkinson's disease", "genetics" and "Brazil". Two independent reviewers extracted the data. For the genes LRRK2 and PRKN, the estimated prevalence was calculated for each study, and a meta-analysis was performed. Results: A total of 32 studies were included, comprising 94 Brazilian patients with PD with a causative mutation, identified from among 2,872 screened patients (3.2%). PRKN mutations were causative of PD in 48 patients out of 576 (8.3%). LRRK2 mutations were identified in 40 out of 1,556 patients (2.5%), and p.G2019S was the most common mutation (2.2%). Conclusions: PRKN is the most common autosomal recessive cause of PD, and LRRK2 is the most common autosomal dominant form. We observed that there was a lack of robust epidemiological studies on PD genetics in Brazil and, especially, that the diversity of Brazil’s population had not been considered.

https://doi.org/10.1590/0004-282x-anp-2020-0409 282 downloads

IV Brazilian Consensus on Rhinitis - an update on allergic rhinitis,
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Sakano, Eulalia

; Sarinho, Emanuel S.C.

; Cruz, Alvaro A.

; Pastorino, Antonio C.

; Tamashiro, Edwin

; Kuschnir, Fábio

; Castro, Fábio F.M.

; Romano, Fabrizio R.

; Wandalsen, Gustavo F.

; Chong-Neto, Herberto J.

; Mello Jr., João F. de

; Silva, Luciana R.

; Rizzo, Maria Cândida

; Miyake, Mônica A.M.

; Rosário Filho, Nelson A.

; Rubini, Norma de Paula M.

; Mion, Olavo

; Camargos, Paulo A.

; Roithmann, Renato

; Godinho, Ricardo N.

; Pignatari, Shirley Shizue N.

; Sih, Tania

; Anselmo-Lima, Wilma T.

; Solé, Dirceu

Brazilian Journal of Otorhinolaryngology

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jan 2018, Volume 84 N. 1 Pages 3 - 14

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Introdução As diretrizes sobre rinite alergica visam atualizar os conhecimentos sobre a doença e os cuidados para com esses pacientes. A iniciativa designada "Rinite Alergica e seu Impacto na Asma", cujo relatorio inicial foi publicado em 2001 e atualizada em 2008 e 2010, tem sido muito bem sucedida na disseminaçao de informaçoes e evidencias, bem como na formulaçao da classificaçao de gravidade e proposta de sistematizaçao do tratamento. Entretanto, visando a participaçao de outros profissionais medicos no atendimento da rinite alergica, e importante o desenvolvimento de algoritmos que indiquem com precisao o que deve e pode ser feito regionalmente. Objetivo Atualizar o III Consenso Brasileiro sobre Rinites-2012, com elaboraçao de algoritmo para conduta da rinite alergica. Método Foram convidados 24 especialistas indicados pelas Associaçao Brasileira de Alergia e Imunologia, Associaçao Brasileira de Otorrinolaringologia e Cirurgia Cervico-Facial e Sociedade Brasileira de Pediatria para atualizaçao do documento de 2012. Resultados A atualizaçao do ultimo Consenso Brasileiro sobre Rinites, incorporou e adaptou para a realidade brasileira as informaçoes relevantes publicadas em todos os documentos da Iniciativa "Rinite Alergica e seu Impacto na Asma", trazendo novos conceitos como a rinite alergica local, novos medicamentos e metodos de avaliaçao de tratamento. Conclusão Proposto um fluxograma de tratamento para a rinite alergica.

Abstract Introduction The guidelines on allergic rhinitis aim to update knowledge about the disease and care for affected patients. The initiative called "Allergic Rhinitis and its Impact on Asthma", initially published in 2001 and updated in 2008 and 2010, has been very successful in disseminating information and evidence, as well as providing a classification of severity and proposing a systemized treatment protocol. In order to include the participation of other medical professionals in the treatment of allergic rhinitis, it is important to develop algorithms that accurately indicate what should and can be done regionally. Objective To update the III Brazilian Consensus on Rhinitis - 2012, with the creation of an algorithm for allergic rhinitis management. Methods We invited 24 experts nominated by the Brazilian Association of Allergy and Immunology, Brazilian Association of Otorhinolaryngology and Head and Neck Surgery and Brazilian Society of Pediatrics to update the 2012 document. Results The update of the last Brazilian Consensus on Rhinitis incorporated and adapted the relevant information published in all "Allergic Rhinitis and its Impact on Asthma" Initiative documents to the Brazilian scenario, bringing new concepts such as local allergic rhinitis, new drugs and treatment evaluation methods. Conclusion A flowchart for allergic rhinitis treatment has been proposed.

https://doi.org/10.1016/j.bjorl.2017.10.006 26131 downloads

Influence of context in social participation of people with disabilities in Brazil
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Silva, Fabiana C. M.

; Sampaio, Rosana F.

; Ferreira, Fabiane R.

; Camargos, Vitor P.

; Neves, Jorge A.

Revista Panamericana de Salud Pública

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oct 2013, Volume 34 N. 4 Pages 250 - 256

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

OBJECTIVE: To identify environmental and personal factors associated with social participation in adults with various diseases/health conditions residing in the urban areas of the Belo Horizonte Metropolitan Region, Minas Gerais, Brazil. METHODS: Individual characteristics, social participation, and perception of environmental barriers of 226 patients treated at a public rehabilitation referral service were evaluated. Regression analyses with hierarchical entry of data were performed to verify the association of personal and environmental factors with social participation. RESULTS: More years of schooling, being engaged in the labor market, and consuming alcohol are conditions that increase the social participation of patients. Natural environment, transportation, access to health services, and social capital are perceived as the most important barriers to participation. Based on the linear regression analysis, the adjusted coefficient (R²adj) of the full model was 0.42 (P = 0.000). CONCLUSIONS: The results of this study may contribute to the planning and implementation of interventions and public policies at the individual and contextual level that are considered appropriate for reducing barriers and facilitate full participation.

OBJETIVO: Determinar los factores ambientales y personales asociados con la participación social de los adultos, en diversas situaciones de enfermedad o salud, que residen en las zonas urbanas de la Región Metropolitana de Belo Horizonte, del estado de Minas Gerais (Brasil). MÉTODOS: Se evaluaron las características individuales, la participación social y la percepción de las barreras ambientales de 226 pacientes tratados en un servicio público de rehabilitación de referencia. Se llevaron a cabo análisis de regresión con entrada jerárquica de los datos para comprobar la asociación de los factores personales y ambientales con la participación social. RESULTADOS: Un mayor número de años de escolarización, estar ocupado en el mercado de trabajo y el consumo de alcohol son condiciones que aumentan la participación social de los pacientes. El entorno natural, el transporte, el acceso a los servicios de salud y el capital social se perciben como las barreras más importantes a la participación. Con base en el análisis de regresión lineal, el coeficiente ajustado (R²aj) del modelo total fue de 0,42 (P = 0,000). CONCLUSIONES: Los resultados de este estudio pueden contribuir a la planificación y la ejecución de las intervenciones y políticas públicas a escalas individual y contextual que se consideren apropiadas para reducir las barreras y facilitar la plena participación.

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Pseudorabies virus can be classified into five genotypes using partial sequences of UL44
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Fonseca Jr., A. A.

; Camargos, M. F.

; Sales, M. L.

; Heinemann, M. B.

; Leite, R.C.

; Reis, J. K. P.

Brazilian Journal of Microbiology

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dec 2012, Volume 43 N. 4 Pages 1632 - 1640

Abstract: En | Text: En | PDF: En

Suid herpesvirus 1 (SuHV-1) is the causative agent of pseudorabies (PR), a disease of great importance due to the huge losses it causes in the swine industry. The aim of this study was to determine a method for genotyping SuHV-1 based on partial sequences of the gene coding for glycoprotein C (gC) and to elucidate the possible reasons for the variability of this region. A total of 109 gCsequences collected from GenBank were divided into five major groups after reconstruction of a phylogenetic tree by Bayesian inference. The analysis showed that a portion of gC (approximately 671 bp) is under selective pressure at various points that coincide with regions of protein disorder. It was also possible to divide SuHV-1 into five genotypes that evolved under different selective pressures. These genotypes are not specific to countries or continents, perhaps due to multiple introduction events related to the importation of swine.

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Rapid thawing human sperm does not affect basic parameters in normozoospermic men: a double-blind prospective study
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Vieira, Marco A.

; Nery, Simone F.

; Tavares, Rubens L.

; Dela Cruz, Cynthia

; Reis, Fernando M.

; Camargos, Aroldo F.

International braz j urol

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feb 2012, Volume 38 N. 1 Pages 108 - 115

Abstract: En | Text: En | PDF: En

PURPOSE: To compare sperm recovery from slow versus rapid thawing technique using thirty-eight normozoospermic human sperm samples, as follows. Twenty-one samples from men taking part in routine infertility screening exams (infertile group) and seventeen from proven fertile volunteer men with at least one child (fertile group). MATERIALS AND METHODS: After analysis of motility, concentration, strict morphology and functional integrity of membranes, sperm was divided into two aliquots of 0.5 mL each and frozen in TyB-G medium. Samples were thawed at room temperature (25 ± 2º C) for 25 minutes (slow thaw) or in a water bath at 75º C for 20 seconds followed by water bath at 37º C for 3 minutes (rapid thaw). After thawing, motility, strict morphology and functional integrity of membranes were evaluated by a blinded investigator. The results were expressed as mean ± standard deviation for parametric variables and analyzed using Student's t-test. Data with unpaired non-parametric variables were expressed as median (interquartile range) and analyzed by the Mann-Whitney test. Wilcoxon test was used to analyze non-parametric paired variables. RESULTS: There was no significant difference between techniques for total and progressive motility, percentage of normal morphological forms, hypoosmotic swelling test. CONCLUSIONS: Although the rapid thawing protocol was completed in a shorter time (three minutes and 20 seconds versus 25 minutes, respectively), it wasn't harmful since both techniques showed comparable spermatozoa recovery. Additional research is needed to confirm its safety in clinical research before introducing this methodology in routine assisted reproduction.

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Impacto de um programa de manejo da asma sobre as hospitalizações e os atendimentos de urgência
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Fontes, Maria J. F.

; Affonso, Alessandra G. A.

; Calazans, Geralda M. C.

; Andrade, Cláudia R. de

; Lasmar, Laura M. L. B. F.

; Nader, Carolina M. F. F.

; Camargos, Paulo A. M.

Jornal de Pediatria

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oct 2011, Volume 87 N. 5 Pages 412 - 418

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

OBJETIVOS: Analisar as frequências de hospitalização e de atendimentos em serviços de urgência ocorridas em crianças e adolescentes antes e após o ingresso em programa de asma no Brasil. MÉTODOS: Prontuários de 608 pacientes menores de 15 anos e com asma foram avaliados retrospectivamente. As frequências de hospitalização por asma e de atendimentos em serviços de urgência para episódios agudos de broncoespasmo foram avaliadas nos períodos anterior e posterior à admissão no programa que disponibiliza medicamentos, preconiza abordagem integral do paciente e manejo profilático de acordo com a Global Initiative for Asthma (GINA). O período de observação antes do programa (AP) teve a duração de 12 meses enquanto o depois do programa (DP) variou de 12 a 36 meses. RESULTADOS: No período AP, ocorreram 895 hospitalizações e 5.375 atendimentos em serviços de urgência, e no período DP, ocorreram 180 hospitalizações e 713 atendimentos na urgência. O teste t de Student para amostras pareadas e o modelo de regressão para observações dependentes identificaram efeito significativo do programa em relação às variáveis estudadas (p = 0,000). CONCLUSÕES: A adoção das recomendações do GINA levou à redução significativa nas frequências de hospitalização e atendimentos na urgência em crianças e adolescentes com asma.

OBJECTIVES: To assess the frequency of hospitalizations and emergency department visits of children and adolescents before and after the enrolment in an asthma program. METHODS: Medical records of 608 asthmatics younger than 15 years were assessed retrospectively. The frequency of hospitalizations and emergency department visits caused by exacerbations were evaluated before and after enrolment in an asthma program. Patients were treated with medications and a wide prophylactic management program based on the Global Initiative for Asthma (GINA). The before asthma program (BAP) period included 12 months before enrollment, whereas the after asthma program (AAP) period ranged from 12 to 56 months after enrollment. RESULTS: In the BAP period, there were 895 hospitalizations and 5,375 emergency department visits, whereas in the AAP period, there were 180 and 713, respectively. This decrease was significant in all statistical analyses (p = 0.000). CONCLUSIONS: Compliance with the GINA recommendations led to a significant decrease in the frequency of hospitalizations and emergency department visits in children and adolescents with asthma.

5589 downloads

O impacto do tratamento fonoaudiológico no controle da asma e da rinite alérgica em crianças e adolescentes respiradores orais
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Campanha, Silvia M. A.

; Fontes, Maria J. F.

; Camargos, Paulo A. M.

; Freire, Lincoln M. S.

Jornal de Pediatria

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jun 2010, Volume 86 N. 3 Pages 202 - 208

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

OBJETIVO: Detectar o impacto do tratamento fonoaudiológico no controle da asma e da rinite alérgica em crianças e adolescentes respiradores orais. MÉTODOS: Trata-se de um estudo quase-experimental; foram randomizados 24 pacientes com asma, rinite alérgica e respiração oral, idade de 6 a 15 anos. Todos os pacientes usavam dipropionato beclometasona inalação oral. No momento em que aceitaram participar da pesquisa, a inalação oral foi substituída pela inalação exclusivamente nasal na inspiração e, após 1 mês, associou-se ao tratamento fonoaudiológico em metade dos pacientes. Esses receberam 16 sessões de tratamento fonoaudiológico em 8 semanas, além do dipropionato de beclometasona inalação exclusivamente nasal (grupo DBF). O grupo de comparação recebeu somente dipropionato beclometasona inalação exclusivamente nasal (grupo DBI). Os dois grupos foram avaliados em cinco tempos. Utilizou-se o escore clínico da rinite alérgica, da asma, o protocolo de avaliação miofuncional orofacial adaptado de Marchesan (2003), a observação dos responsáveis, dados de espirometria, de pico de fluxo inspiratório e de pico de fluxo expiratório. RESULTADOS: Houve melhora significativa do grupo DBF: escores clínicos da asma no tempo 5 (p = 0,046); valores do pico de fluxo inspiratório no tempo 4 (p = 0,030); pico de fluxo expiratório no tempo 3 (p = 0,008); modo respiratório e postura de lábios (p = 0,000) a partir do tempo 3; observação dos responsáveis, no tempo 2, tempo 4 e tempo 5 (p = 0,010; p = 0,027; p = 0,030). CONCLUSÕES: O tratamento fonoaudiológico associado ao dipropionato beclometasona por inalação exclusivamente nasal promoveu um controle clínico e funcional mais precoce e duradouro da asma, da rinite alérgica e da respiração oral entre os grupos estudados.

OBJECTIVE: To determine the impact of speech therapy on asthma and allergic rhinitis control in mouth breathing children and adolescents. METHODS: This was a quasi-experimental randomized study of 24 mouth breathing patients with asthma and allergic rhinitis, aged from 6 to 15 years. All patients were taking beclomethasone diproprionate through oral inhalation at the start of the study. At enrollment on the study, oral inhalation was substituted with exclusively nasal inhalation and 1 month later half of the patients began speech therapy. They attended 16 speech therapy sessions in 8 weeks and continued taking beclomethasone dipropionate through exclusively nasal inhalation (BDT group). The comparison group received only beclomethasone diproprionate through exclusively nasal inhalation (BDI group). Both groups were assessed five times. Clinical scores were calculated for allergic rhinitis and asthma, an adapted version of the Marchesan orofacial myofunctional assessment protocol was applied, and parents/guardians' observations were recorded, in addition to spirometry measurements of peak inspiratory and peak expiratory flow. RESULTS: There were significant improvements in the BDT group: clinical asthma score at T5 (p = 0.046); peak inspiratory flow at T4 (p = 0.030); peak expiratory flow at T3 (p = 0.008); breathing mode and lip position (p = 0.000) from T3 onwards; and parents/guardians' observations at T2, T4, and T5 (p = 0.010; p = 0.027; p = 0.030). CONCLUSIONS: Speech therapy in combination with beclomethasone diproprionate through exclusively nasal inhalation resulted in earlier and longer-lasting clinical and functional control of asthma, allergic rhinitis, and mouth breathing than was achieved in the group that only took beclomethasone diproprionate.

7925 downloads

Adaptação transcultural e avaliação das propriedades psicométricas da Falls Efficacy Scale - International em idosos Brasileiros (FES-I-BRASIL)
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Camargos, Flávia F. O.

; Dias, Rosângela C.

; Dias, João M. D.

; Freire, Maria T. F.

Brazilian Journal of Physical Therapy

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jun 2010, Volume 14 N. 3 Pages 237 - 243

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

OBJETIVOS: Adaptar culturalmente a Falls Efficacy Scale-International (FES-I) e avaliar suas propriedades psicométricas em uma amostra de idosos brasileiros da comunidade. MÉTODOS: Conforme recomendações da Rede Européia de prevenção às quedas, o instrumento foi traduzido para o português do Brasil e adaptado culturalmente para a população brasileira (FES-I-Brasil). A FES-I-Brasil foi aplicada em 163 idosos (73,44±5,51 anos), e foram coletados dados demográficos e relacionados à história de quedas. Dentre esses idosos, 58 foram distribuídos aleatoriamente para avaliação da confiabilidade. A confiabilidade foi analisada pelo Índice de Correlação Intraclasse (ICC) e a consistência interna pelo α de Cronbach. A estrutura interna da FES-I-Brasil foi avaliada pela análise fatorial exploratória. O modelo de regressão logística foi utilizado para identificar quais tarefas da escala eram mais relevantes para discriminar quedas. Para análise de sensibilidade e especificidade da FES-I-Brasil, empregou-se a curva Receiving Operator Characteristic (ROC). RESULTADOS: A consistência interna da FES-I-Brasil foi α=0,93, e a confiabilidade foi ICC=0,84 e 0,91 (intra e interexaminadores, respectivamente). A análise fatorial sugeriu dois fatores que verificavam preocupação em cair durante atividades de socialização e de vida diária (básicas e instrumentais) e tarefas relacionadas ao controle postural. Uma pontuação >23 pontos na FES-I-Brasil sugeriu associação com histórico de queda esporádica, ao passo que uma pontuação >31 pontos ensejou uma associação com queda recorrente. CONCLUSÕES: A FES-I-Brasil apresentou-se semântica, linguística e psicometricamente adequada para avaliar o medo de cair na população de idosos brasileiros da comunidade.

OBJECTIVES: To culturally adapt the Falls Efficacy Scale - International (FES-I) and assess its psychometric properties in a sample of community-dwelling elderly Brazilians. METHODS: The instrument was translated into Brazilian Portuguese and culturally adapted to the Brazilian population (FES-I-Brazil) as recommended by the Prevention of Falls Network Europe. FES-I-Brazil was applied to 163 elderly people (73.44±5.51 years), and the demographic data and history of falls were also collected. From this group, 58 participants were randomly distributed to evaluate reliability. The reliability was analyzed using the intraclass correlation coefficient (ICC) and the internal consistency, using Cronbach's alpha coefficient (α). The internal structure of FES-I-Brazil was evaluated by means of exploratory factor analysis. The logistic regression model was used to determine which tasks on the scale were more relevant for discriminating falls. To analyze the sensitivity and specificity of FES-I-Brazil, the receiver operating characteristic (ROC) curve was used. RESULTS: The internal consistency of FES-I-Brazil was α=0.93, and the intra- and inter-examiner reliability were ICC=0.84 and 0.91, respectively. Factor analysis suggested two factors: concern about falling during social activities and activities of daily living (basic and instrumental), and postural control tasks. FES-I-Brazil scores >23 suggested an association with a previous history of sporadic falls, whereas scores >31 suggested an association with recurrent falls. CONCLUSIONS: FES-I-Brazil was shown to be semantically, linguistically and psychometrically appropriate to evaluate the fear of falling in the community-dwelling Brazilian elderly population.

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10.

Classification of journals in the QUALIS System of CAPES URGENT need of changing the criteria!
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Andriolo, Adagmar

; Souza, Aécio Flávio Meireles

; Farias, Alberto Queiroz

; Barbosa, Alfredo José Afonso

; França Netto, Antonio Spina

; Hernandez, Arnaldo José

; Camargos, Aroldo F.

; Barraviera, Benedito

; Kadunc, Bogdana Victoria

; Caramelli, Bruno

; Campos, Carlos Eduardo Aguilera

; Brites, Carlos

; Nascimento, Dejair Caitano do

; Braile, Domingo M.

; Goldenberg, Dov Charles

; Baracat, Edmund Chada

; Kimura, Edna T.

; Marchiori, Edson

; Vieira, Eduardo de Paula

; Almeida, Eros Antônio de

; Jotz, Geraldo Pereira

; Camanho, Gilberto

; Friedman, Gilberto

; Cerri, Giovanni Guido

; Duarte, Ivomar Gomes

; Costa, Izelda Maria Carvalho

; Mello Júnior, João Ferreira de

; Faintuch, Joel

; Martinez, José Antônio Baddini

; Antonio Livramento, José

; Manso, José Eduardo Ferreira

; Amaral, José Luiz Gomes do

; Battistella, Linamara Rizzo

; Machado, Luís dos Ramos

; Moreira, Luiz Felipe P.

; Gebrim, Luiz Henrique

; Madeira, Marcelo

; Riberto, Marcelo

; Bastos, Marcus

; Falcão, Mário Cícero

; Conceição, Mario J. da

; Silva, Mauricio Rocha e

; Ruiz, Milton Artur

; Shibata, Milton K.

; Santiago, Mittermayer Barreto

; Andreollo, Nelson Adami

; Malafaia, Osvaldo

; Martins, Regina Helena Garcia

; Procianoy, Renato Soibelmann

; Baroudi, Ricardo

; Fuller, Ricardo

; Viebig, Ricardo Guilherme

; Nitrini, Ricardo

; Moura, Rita Cristina Mainieri R. de

; Dedivitis, Rogério

; Damião, Ronaldo

; Lianza, Sergio

; Rode, Sigmar de Mello

; Yoshida, Winston Bonetti

; Handar, Zuher

Arquivos de Neuro-Psiquiatria

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apr 2010, Volume 68 N. 2 Pages 327 - 329

Abstract: En | Text: En | PDF: En

3236 downloads Cited 9 times in SciELO

11.

Classificação dos Periódicos no Sistema QUALIS da CAPES - a Mudança dos Critérios é URGENTE!
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Andriolo, Adagmar

; Souza, Aécio Flávio Meireles

; Farias, Alberto Queiroz

; Barbosa, Alfredo José Afonso

; França Netto, Antonio Spina

; Hernandez, Arnaldo José

; Camargos, Aroldo F.

; Barraviera, Benedito

; Kadunc, Bogdana Victoria

; Caramelli, Bruno

; Campos, Carlos Eduardo Aguilera

; Brites, Carlos

; Nascimento, Dejair Caitano do

; Braile, Domingo M.

; Goldenberg, Dov Charles

; Kimura, Edna T

; Marchiori, Edson

; Vieira, Eduardo de Paula

; Almeida, Eros Antônio de

; Jotz, Geraldo Pereira

; Camanho, Gilberto

; Friedman, Gilberto

; Cerri, Giovanni Guido

; Duarte, Ivomar Gomes

; Costa, Izelda Maria Carvalho

; Mello Júnior, João Ferreira de

; Faintuch, Joel

; Martinez, José Antônio Baddini

; Livramento, José Antonio

; Manso, José Eduardo Ferreira

; Battistella, Linamara Rizzo

; Machado, Luís dos Ramos

; Moreira, Luiz Felipe P.

; Gebrim, Luiz Henrique

; Madeira, Marcelo

; Riberto, Marcelo

; Bastos, Marcus

; Falcão, Mário Cícero

; Conceição, Mario J. da

; Rocha e Silva, Mauricio

; Ruiz, Milton Artur

; Shibata, Milton K.

; Santiago, Mittermayer Barreto

; Andreollo, Nelson Adami

; Malafaia, Osvaldo

; Martins, Regina Helena Garcia

; Procianoy, Renato Soibelmann

; Baroudi, Ricardo

; Fuller, Ricardo

; Viebig, Ricardo Guilherme

; Nitrini, Ricardo

; Moura, Rita Cristina Mainieri R. de

; Dedivitis, Rogério

; Damião, Ronaldo

; Lianza, Sergio

; Rode, Sigmar de Mello

; Yoshida, Winston Bonetti

; Handar, Zuher

Arquivos Brasileiros de Cardiologia

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mar 2010, Volume 94 N. 3 Pages 290 - 291

Abstract: Pt | Text: Pt | PDF: Pt

3995 downloads Cited 2 times in SciELO

12.

Classificação dos periódicos no Sistema Qualis da Capes: a mudança dos critérios é urgente!
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Andriolo, Adagmar

; Barbosa, Alfredo José Afonso

; França Netto, Antonio Spina

; Hernandez, Arnaldo José

; Camargos, Aroldo F.

; Barraviera, Benedito

; Kadunc, Bogdana Victoria

; Caramelli, Bruno

; Campos, Carlos Eduardo Aguilera

; Brites, Carlos Roberto

; Braile, Domingo M.

; Goldenberg, Dov Charles

; Kimura, Edna T

; Marchiori, Edson

; Vieira, Eduardo de Paula

; Sampaio, Francisco J. B.

; Jotz, Geraldo Pereira

; Camanho, Gilberto

; Friedman, Gilberto

; Cerri, Giovanni Guido

; Duarte, Ivomar Gomes

; Costa, Izelda Maria Carvalho

; Mello Júnior, João Ferreira de

; Faintuch, Joel

; Martinez, José Antônio Baddini

; Livramento, José Antonio

; Manso, José Eduardo Ferreira

; Battistella, Linamara Rizzo

; Machado, Luís dos Ramos

; Moreira, Luiz Felipe P.

; Gebrim, Luiz Henrique

; Madeira, Marcelo

; Riberto, Marcelo

; Bastos, Marcus

; Falcão, Mário Cícero

; Silva, Mauricio Rocha e

; Ruiz, Milton Artur

; Shibata, Milton K.

; Santiago, Mittermayer Barreto

; Martins, Regina Helena Garcia

; Procianoy, Renato Soibelmann

; Baroudi, Ricardo

; Fuller, Ricardo

; Viebig, Ricardo Guilherme

; Nitrini, Ricardo

; Dedivitis, Rogério

; Damião, Ronaldo

; Lianza, Sergio

; Rode, Sigmar de Mello

; Yoshida, Winston Bonetti

; Handar, Zuher

Revista Brasileira de Hematologia e Hemoterapia

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feb 2010, Volume 32 N. 1 Pages 1 - 3

Abstract: Pt | Text: Pt | PDF: Pt

3073 downloads Cited 2 times in SciELO

13.

Cortisol basal em asmáticos em uso de duas diferentes doses de propionato de fluticasona
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Andrade, Cláudia R. de

; Camargos, Paulo Augusto M.

; Ibiapina, Cássio da C.

; Lasmar, Laura Maria de L. B. F.

Jornal de Pediatria

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aug 2008, Volume 84 N. 4 Pages 373 - 376

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

OBJETIVOS: Avaliar os valores de cortisol basal em asmáticos persistentes em uso de propionato de fluticasona inalatório na dose de 200 ou 300 mcg/dia. MÉTODOS: O diagnóstico e a classificação da gravidade da asma basearam-se nas recomendações do Global Initiative for Asthma. Pacientes menores de 11 anos receberam fluticasona na dose de 200 mcg/dia, e aqueles com mais de 11 anos receberam 300 mcg/dia. Após 10 semanas de tratamento, a dosagem do cortisol foi realizada para avaliação da função adrenal. RESULTADOS: Foram avaliados 41 pacientes (65,9% do sexo masculino) entre 6 e 18 anos. Não houve diferença significativa entre as médias de cortisol basal nos pacientes que receberam 200 mcg/dia de propionato de fluticasona (n = 13) e naqueles que receberam 300 mcg/dia (n = 28). CONCLUSÕES: Os achados mostram que doses baixas a moderadas de propionato de fluticasona não causam supressão adrenal.

OBJECTIVES: To evaluate basal plasma cortisol in persistent asthmatics on inhaled fluticasone propionate 200 mcg/day and 300 mcg/day. METHODS: Asthma diagnosis and classification was based on Global Initiative for Asthma recommendations. Patients aged 11 years old or less received fluticasone propionate 200 mcg/day and those older than 11 years received 300 mcg/day. After 10 weeks of treatment, plasma cortisol levels were monitored to evaluate the hypothalamic-pituitary-adrenal axis. RESULTS: Forty-one patients (65.9% males) aged 6 to 18 years old were evaluated. No statistical differences were found between plasma cortisol levels in patients who received 200 mcg/day (n = 13) and those who received 300 mcg/day (n = 28). CONCLUSIONS: Our results show that low and moderate doses of fluticasone propionate do not cause adrenal suppression.

4048 downloads

14.

Refluxo gastroesofágico e asma na infância: um estudo de sua relação através de monitoramento do pH esofágico
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Teixeira, Beatriz C.

; Norton, Rocksane C.

; Penna, Francisco J.

; Camargos, Paulo A.

; Lasmar, Laura M. L. B. F.

; Macedo, Antonio V.

Jornal de Pediatria

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dec 2007, Volume 83 N. 6 Pages 535 - 540

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

OBJETIVOS: Este trabalho tem como objetivo verificar a prevalência do refluxo gastroesofágico em crianças com asma e avaliar se o índice de refluxo tem uma boa sensibilidade e especificidade para o diagnóstico de refluxo gastroesofágico. MÉTODOS: Foram estudadas 69 crianças de 1 a 5 anos, com asma, através do exame de pHmetria de 24 horas. RESULTADOS: A idade das crianças variou de 12,4 a 63,1 meses, com uma média de 30,79, sendo que 62,3% eram do sexo masculino. O refluxo gastroesofágico foi observado em 68,1% das crianças. Quando separados os pacientes em duas categorias (asma moderada e grave), a associação foi de 58,5 e 82,1%, respectivamente. O refluxo gastroesofágico oculto ocorreu em 31,8% dos casos. O índice de refluxo mostrou uma sensibilidade de 89,4%, especificidade de 95,5%, valor preditivo positivo de 97,7% e valor preditivo negativo de 80,8%. CONCLUSÕES: Os resultados obtidos neste estudo indicam uma elevada associação entre o refluxo gastroesofágico e a asma e sugerem que o índice de refluxo, como parâmetro único, tem uma boa sensibilidade e especificidade para o diagnóstico da doença do refluxo gastroesofágico.

OBJECTIVES: This study aims at verifying the prevalence of gastroesophageal reflux in asthmatic children, and at determining the sensitivity and specificity of the reflux index for the diagnosis of gastroesophageal reflux disease. METHODS: Sixty-nine children, aged 1-5 years, with asthma, were studied by 24-hour pH monitoring. The patients were randomly selected. RESULTS: Ages varied from 12.4 to 63.1 months, mean age = 30.79 months, and 62.3% were males. Gastroesophageal reflux was observed in 68.1% of the children. The patients were divided into two groups, moderate and severe asthma, and gastroesophageal reflux was diagnosed in 58.5 and 82.1% of the cases, respectively. Occult gastroesophageal reflux occurred in 31.8% of the cases. The reflux index showed an sensitivity of 89.4%, specificity of 95.5%, positive predictive value of 97.7% and negative predictive value of 80.8%. CONCLUSIONS: The results of this study indicate a relationship between gastroesophageal reflux and asthma, and suggest that the reflux index as a single parameter of pH monitoring has good sensitivity and specificity for the diagnosis of gastroesophageal reflux disease.

6390 downloads

15.

Prevalência da rinite alérgica e seu impacto na utilização dos serviços de pronto-atendimento em um grupo de crianças e adolescentes com asma persistente moderada e grave
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Lasmar, Laura M. L. B. F.

; Camargos, Paulo A. M.

; Ordones, Alexandre Beraldo

; Gaspar, Guilherme Rache

; Campos, Eduardo Goulart

; Ribeiro, Gustavo Augusto

Jornal de Pediatria

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dec 2007, Volume 83 N. 6 Pages 555 - 561

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

OBJETIVOS: Avaliar a prevalência da rinite alérgica (RA) e os fatores associados à utilização de serviços de pronto-atendimento por asma aguda em crianças e adolescentes asmáticos tratados com corticóide inalatório. MÉTODOS: Foi realizado um estudo transversal, do qual participaram 126 pacientes que se encontravam em tratamento com o dipropionato de beclometasona por 3 anos. Através de modelos de regressão logística, foram avaliados os fatores associados à consulta de pronto-atendimento no terceiro ano de tratamento com dipropionato de beclometasona. RESULTADOS: A prevalência da rinite alérgica foi de 74,6% (IC95% 65,9-81,7). A presença de rinite alérgica (OR = 2,98, IC95% 1,10-8,06) e a gravidade da asma (OR = 2,09, IC95% 1,05-4,44) foram fatores independentes para consultas em pronto-atendimento. CONCLUSÃO: A rinite alérgica apresentou elevada prevalência no grupo estudado e, aliada à gravidade da asma, foi o principal fator de risco para as consultas de pronto-atendimento. Os serviços de saúde deveriam ficar atentos para o reconhecimento precoce da rinite alérgica nos pacientes com asma.

OBJECTIVE:To assess the prevalence of allergic rhinitis and the factors associated with the use of emergency care services by children and adolescents with acute asthma submitted to inhaled corticosteroid therapy. METHODS: A cross-sectional study was conducted with 126 patients treated with beclomethasone dipropionate for 3 years. The factors associated with emergency care services in the third year of beclomethasone dipropionate treatment were assessed using logistic regression models. RESULTS: The prevalence of allergic rhinitis amounted to 74.6% (95%CI 65.9-81.7). The presence of allergic rhinitis (OR = 2.98, 95%CI 1.10-8.06) and asthma severity (OR = 2.09, 95%CI 1.05-4.44) were independent factors for emergency care services. CONCLUSION: The prevalence of allergic rhinitis was high and that, combined with asthma severity, constituted the major risk factor for the necessity of emergency care services. Health professionals should attempt to make an early diagnosis of allergic rhinitis in asthmatic patients.

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