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[SciELO Preprints] - Anxiety and depression symptoms in university students from public institutions of higher education in Brazil during the covid-19 pandemic: a multicenter study
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Barbosa, Bruna Carolina Rafael Paula, Waléria de Ferreira, Aline Dayrell Freitas, Eulilian Dias de Chagas, Carolina Martins dos Santos Oliveira, Helian Nunes de Ferreira, Lívia Garcia Silva, Luciana Saraiva da Vidigal, Fernanda de Carvalho Nobre, Luciana Neri Machado, Elaine Leandro Cardoso, Clareci Silva Meireles, Adriana Lúcia

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Publication date: 2023-05-25

Abstract: En

This is a multicenter, cross-sectional study carried out with students regularly enrolled in undergraduate courses at eight Brazilian IFES. Data collection was conducted between October 2021 and February 2022 using an online self-completed questionnaire, which addressed sociodemographic and academic characteristics, lifestyle habits, and health conditions. Symptoms of anxiety and depression were assessed using the Depression, Anxiety, and Stress Scale-21 (DASS-21). Variables were analyzed descriptively using frequency distribution and Pearson’s chi-square test. To estimate the prevalence of symptoms of anxiety and depression, the proportion and 95% confidence interval (95%CI) were used. The level of adopted statistical significance was 5%.

https://doi.org/10.1590/SciELOPreprints.6080

Lesão Miocárdica e Prognóstico em Pacientes Hospitalizados com COVID-19 no Brasil: Resultados do Registro Nacional de COVID-19
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Barbosa, Hannah Cardoso

; Martins, Maria Auxiliadora Parreiras

; Jesus, Jordana Cristina de

; Meira, Karina Cardoso

; Passaglia, Luiz Guilherme

; Sacioto, Manuela Furtado

; Bezerra, Adriana Falangola Benjamin

; Schwarzbold, Alexandre Vargas

; Maurílio, Amanda de Oliveira

; Farace, Barbara Lopes

; Silva, Carla Thais Cândida Alves da

; Cimini, Christiane Corrêa Rodrigues

; Silveira, Daniel Vitorio

; Carazai, Daniela do Reis

; Ponce, Daniela

; Costa, Emanuel Victor Alves

; Manenti, Euler Roberto Fernandes

; Cenci, Evelin Paola de Almeida

; Bartolazzi, Frederico

; Madeira, Glícia Cristina de Castro

; Nascimento, Guilherme Fagundes

; Velloso, Isabela Vasconcellos Pires

; Batista, Joanna d’Arc Lyra

; Morais, Júlia Drumond Parreiras de

; Carvalho, Juliana da Silva Nogueira

; Ruschel, Karen Brasil

; Martins, Karina Paula Medeiros Prado

; Zandoná, Liege Barella

; Menezes, Luanna Silva Monteiro

; Kopittke, Luciane

; Castro, Luís César de

; Nasi, Luiz Antônio

; Floriani, Maiara Anschau

; Souza, Maíra Dias

; Carneiro, Marcelo

; Bicalho, Maria Aparecida Camargos

; Lima, Maria Clara Pontello Barbosa

; Godoy, Mariana Frizzo de

; Guimarães-Júnior, Milton Henriques

; Mendes, Paulo Mascarenhas

; Delfino-Pereira, Polianna

; Ribeiro, Raquel Jaqueline Eder

; Finger, Renan Goulart

; Menezes, Rochele Mosmann

; Francisco, Saionara Cristina

; Araújo, Silvia Ferreira

; Oliveira, Talita Fischer

; Oliveira, Thainara Conceição de

; Polanczyk, Carisi Anne

; Marcolino, Milena Soriano

Arquivos Brasileiros de Cardiologia

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2023, Volume 120 N. 2 elocation e20220151

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Background Cardiovascular complications of COVID-19 are important aspects of the disease’s pathogenesis and prognosis. Evidence on the prognostic role of troponin and myocardial injury in Latin American hospitalized COVID-19 patients is still scarce. Objectives To evaluate myocardial injury as independent predictor of in-hospital mortality and invasive mechanical ventilation support in hospitalized patients, from the Brazilian COVID-19 Registry. Methods This cohort study is a substudy of the Brazilian COVID-19 Registry, conducted in 31 Brazilian hospitals of 17 cities, March-September 2020. Primary outcomes included in-hospital mortality and invasive mechanical ventilation support. Models for the primary outcomes were estimated by Poisson regression with robust variance, with statistical significance of p<0.05. Results Of 2,925 patients (median age of 60 years [48-71], 57.1% men), 27.3% presented myocardial injury. The proportion of patients with comorbidities was higher among patients with cardiac injury (median 2 [1-2] vs. 1 [0-2]). Patients with myocardial injury had higher median levels of brain natriuretic peptide, lactate dehydrogenase, creatine phosphokinase, N-terminal pro-brain natriuretic peptide, and C-reactive protein than patients without myocardial injury. As independent predictors, C-reactive protein and platelet counts were related to the risk of death, and neutrophils and platelet counts were related to the risk of invasive mechanical ventilation support. Patients with high troponin levels presented a higher risk of death (RR 2.03, 95% CI 1.60-2.58) and invasive mechanical ventilation support (RR 1.87, 95% CI 1.57-2.23), when compared to those with normal troponin levels. Conclusion Cardiac injury was an independent predictor of in-hospital mortality and the need for invasive mechanical ventilation support in hospitalized COVID-19 patients.

Resumo Fundamento As complicações cardiovasculares da COVID-19 são aspectos importantes da patogênese e do prognóstico da doença. Evidências do papel prognóstico da troponina e da lesão miocárdica em pacientes hospitalizados com COVID-19 na América Latina são ainda escassos. Objetivos Avaliar a lesão miocárdica como preditor independente de mortalidade hospitalar e suporte ventilatório mecânico em pacientes hospitalizados, do registro brasileiro de COVID-19. Métodos Este estudo coorte é um subestudo do registro brasileiro de COVID-19, conduzido em 31 hospitais brasileiros de 17 cidades, de março a setembro de 2020. Os desfechos primários incluíram mortalidade hospitalar e suporte ventilatório mecânico invasivo. Os modelos para os desfechos primários foram estimados por regressão de Poisson com variância robusta, com significância estatística de p<0,05. Resultados Dos 2925 pacientes [idade mediana de 60 anos (48-71), 57,1%], 27,3% apresentaram lesão miocárdica. A proporção de pacientes com comorbidades foi maior nos pacientes com lesão miocárdica [mediana 2 (1-2) vs. 1 (0-20)]. Os pacientes com lesão miocárdica apresentaram maiores valores medianos de peptídeo natriurético cerebral, lactato desidrogenase, creatina fosfoquinase, N-terminal do pró-peptídeo natriurético tipo B e proteína C reativa em comparação a pacientes sem lesão miocárdica. Como fatores independentes, proteína C reativa e contagem de plaquetas foram relacionados com o risco de morte, e neutrófilos e contagem de plaquetas foram relacionados ao risco de suporte ventilatório mecânico invasivo. Os pacientes com níveis elevados de troponina apresentaram um maior risco de morte (RR 2,03, IC95% 1,60-2,58) e suporte ventilatório mecânico (RR 1,87;IC95% 1,57-2,23), em comparação àqueles com níveis de troponina normais. Conclusão Lesão cardíaca foi um preditor independente de mortalidade hospitalar e necessidade de suporte ventilatório mecânico em pacientes hospitalizados com COVID-19.

https://doi.org/10.36660/abc.20220151

Non-destructive assessment of quality traits in apples and pears using near infrared spectroscopy and chemometrics
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Vilvert, João Claudio

; Santos, Luana Ferreira dos

; Cardoso, Adriana Dias

; Lopes, Paulo Roberto Coelho

; Amarante, Cassandro Vidal Talamini do

; Freitas, Sérgio Tonetto de

Revista Brasileira de Fruticultura

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2023, Volume 45 elocation e-969

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract The objective of this study was to evaluate the performance of a handheld NIR spectrometer for non-destructive quality analysis of apples and pears produced in the Brazilian Semi-arid region. NIR spectra were acquired with a portable spectrometer in the wavelength range of 750–1065 nm and reference analyses of dry matter content (DMC) and soluble solids content (SSC) were measured weekly during 10 weeks of storage at 0.5 °C. Spectra were pre-processed with standard normal variate and used to develop DMC and SSC models using partial least squares regression with full cross-validation. The models were validated using data not included in the calibration. Satisfactory prediction results were obtained for SSC in apples (R² = 0.58) and pears (R² = 0.55), and for DMC in apples (R² = 0.55) and pears (R² = 0.65). All prediction models showed a relative root mean square error of prediction lower than 8%. These findings indicate that the NIR spectrometer is a promising tool to be used for a rapid and non-destructive determination of internal quality traits in apples and pears.

Resumo O objetivo deste estudo foi avaliar o desempenho de um espectrômetro portátil NIR na análise não destrutiva da qualidade de maçãs e peras produzidas na região semiárida brasileira. Os espectros NIR foram coletados com um espectrômetro portátil na faixa de comprimentos de onda de 750–1.065 nm, e as análises de referência de conteúdo de matéria seca (CMS) e conteúdo de sólidos solúveis (CSS) foram mensurados semanalmente durante 10 semanas de armazenamento a 0,5 °C. Os espectros foram pré-processados com a variação normal padrão e utilizados para desenvolver modelos de CMS e CSS usando a regressão dos quadrados mínimos parciais com validação cruzada completa. Os modelos foram validados externamente usando dados não incluídos na calibração. Resultados de predição satisfatórios foram obtidos para CSS em maçãs (R² = 0.58) e peras (R² = 0.55), e para CMS em maçãs (R² = 0.55) e peras (R² = 0.65). Todos os modelos de predição apresentaram raiz quadrada do erro médio quadrático de predição relativo menor que 8%. Estes resultados indicam que o espectrômetro NIR é uma ferramenta promissora para uma determinação rápida e não destrutiva dos atributos de qualidade interna de maçãs e peras.

https://doi.org/10.1590/0100-29452023969

Limites e possibilidades das flexibilidades do direito da propriedade intelectual para lidar com urgências em saúde: estudos de caso da Aids e da covid-19
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Varella, Marcelo Dias

; Oliveira, Katia Adriana Cardoso de

Revista Direito GV

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2023, Volume 19 elocation e2326

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract The aim of this paper is to demonstrate that intellectual property rights become flexible enough to expand the supply of medicines and vaccines, in addition to enabling development and innovation. In order to understand this dynamic, we started with a systematic literature review, with the object of analyzing three case studies in which the performance of different international and national actors is observed. The first deals with the legislative actions in the country, which made possible the decree of the compulsory license of the Efavirenz patent, by the Executive Power in 2007, during the sanitary crisis of AIDS. The second demonstrates that the Covid-19 pandemic was strong enough to spur vaccine innovation and development; but it still has problems with production capacity, whose solution proposed at the World Trade Organization (WTO) was the waiver of patents. Finally, the Brazilian Judiciary, in the context of the Covid-19 pandemic, made the Intellectual Property Law more flexible, by removing the sole paragraph of art. 40 of the Law of Intellectual Property (LPI), in Direct Action of Unconstitutionality (ADI) 5,529, and the Power promoted several changes in the LPI, to face the crisis. It is concluded that the dynamics of the norms that govern Intellectual Property Law allow for different possibilities of flexibility, depending on each concrete problem, to function as a kind of “emergency intellectual property right”.

Resumo O objetivo deste artigo é demonstrar que o direito de propriedade intelectual torna-se flexível o suficiente para ampliar a oferta de medicamentos e vacinas, além de viabilizar desenvolvimento e inovação. Para compreender essa dinâmica, partiu-se de uma revisão sistemática da literatura, tendo por objeto a análise de três estudos de casos em que se observa a atuação dos diversos atores internacionais e nacionais. O primeiro trata das ações legislativas no país, que possibilitaram a decretação da licença compulsória da patente do Efavirenz, pelo Poder Executivo em 2007, durante a crise sanitária da Aids. O segundo demonstra que a pandemia de covid-19 foi forte o suficiente para estimular a inovação e o desenvolvimento de vacinas, mas ainda encontra problemas com a capacidade de produção, cuja solução proposta na Organização Mundial do Comércio (OMC) foi o waiver de direitos de propriedade intelectual. Por fim, o Poder Judiciário brasileiro, no contexto da pandemia de covid-19, flexibilizou o direito de propriedade intelectual ao retirar o parágrafo único do art. 40 da Lei de Propriedade Industrial (LPI), na Ação Direta de Inconstitucionalidade (ADI) 5.529, e os Poderes Legislativo e Executivo promoveram diversas alterações na LPI para enfrentamento da crise. Conclui-se que a dinâmica das normas que regem o direito de propriedade intelectual permite diferentes possibilidades de flexibilizações, a depender de cada problema concreto, a funcionar como uma espécie de “direito de propriedade intelectual de emergência”.

https://doi.org/10.1590/2317-6172202326

The role of neck ultrasound in the follow-up of low- and intermediate- risk papillary thyroid cancer
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Lopes, Sara Gomes de Campos

; Ferreira, David Nuno Dias Silva

; Fernandes, Vera Adriana Ribeiro

; Marques, Helena Manuela da Costa Cardoso

; Pereira, Ricardo Fernando da Silva Santos

; Monteiro, Ana Margarida Carvalho

Archives of Endocrinology and Metabolism

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aug 2022, Volume 66 N. 4 Pages 481 - 488

Abstract: En | Text: En | PDF: En

ABSTRACT Objective: The optimal time for a neck ultrasound (US) in the follow-up of papillary thyroid cancer (PTC) after the first year is undetermined. We aimed to verify the utility of routine neck US in the surveillance of patients diagnosed with low- and intermediate-risk PTC with no evidence of disease at the one-year assessment. Materials and methods: We conducted a retrospective longitudinal study of patients with low- and intermediate-risk PTC with normal neck US, unstimulated serum thyroglobulin (Tg) < 1 ng/mL and negative anti-Tg antibodies at the one-year follow-up. Patients were divided into group 1 [undetectable Tg (<0.20 ng/mL)] and group 2 [detectable Tg but < 1 ng/mL]. The negative predictive value (NPV) of the one-year unstimulated Tg at the five-year and last follow-up visits was calculated. Results: We included n = 88 patients in group 1 and n = 8 patients in group 2. No patient from group 1 presented suspicious US findings at the five-year evaluation [NPV: 100.0% (95% confidence interval (CI): 95.5%-100.0%)], and at the last visit, only one patient had developed a lymph node classified as suspicious [NPV: 98.8% (95% CI: 93.2%-100.0%); mean follow-up: 6.7 years]. In group 2, two patients’ USs presented suspicious findings at the five-year evaluation [NPV: 75.0% (95% CI: 34.9%-96.8%)]. At the last visit, only one patient persisted with suspicious findings in the US [NPV: 87.5% (95% CI: 47.4%-99.7%); mean follow-up: 6.5 years]. Conclusion: Low- and intermediate-risk PTC with an excellent response to treatment at the one-year assessment can be safely monitored with regular unstimulated Tg assessments. Conclusions should not be drawn for Tg levels between 0.20-0.99 ng/mL.

https://doi.org/10.20945/2359-3997000000485

Prevalência de infecção por SARS-CoV-2 e fatores associados em pessoas privadas de liberdade no Espírito Santo, Brasil
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Bianchi, Erika do Nascimento

; Macedo, Laylla Ribeiro

; Maciel, Ethel Leonor Noia

; Sá, Ricardo Tristão

; Silva, Adriana Ilha da

; Duque, Camila Leal Cravo

; Jabor, Pablo Medeiros

; Gomes, Cristiana Costa

; Cardoso, Orlei Amaral

; Lira, Pablo Silva

; Zanotti, Raphael Lubiana

; Magno Filho, Silvânio José de Souza

; Zandonade, Eliana

Cadernos de Saúde Pública

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2022, Volume 38 N. 2 elocation e00094721

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

O objetivo foi estimar o percentual de pessoas privadas de liberdade no Espírito Santo, Brasil, infectados com o SARS-CoV-2 e apresentar os fatores associados ao resultado positivo. Trata-se de um inquérito sorológico, realizado entre os dias 31 de agosto e 4 de setembro de 2020, nas 34 unidades prisionais do estado. Realizou-se uma entrevista e testes sorológicos para detecção de IgG e IgM no grupo estudado. Foram avaliadas 844 pessoas privadas de liberdade, 265 testaram positivo para COVID-19, indicando uma prevalência de 31,64% (IC9%%: 28,44-34,83). Observou-se associação estatística entre resultado positivo e localização do presídio na região norte (p = 0,001), regime de prisão fechado (p = 0.002) e sexo masculino (p = 0.005). Destaca-se ainda que todos os sintomas foram observados em menor frequência no grupo dos positivos, assim como uma baixa prevalência de comorbidades (0 a 7,1%). Os resultados permitiram conhecer as características dessa população vulnerável a fim de direcionar ações de saúde.

The study aimed to estimate the proportion of prison inmates in the state of Espírito Santo, Brazil, with SARS-CoV-2 infection and to present factors associated with positive test result. This was a serological survey conducted from August 31 to September 4, 2020, in the state’s 34 prison units. An interview and serological tests were performed for detection of IgG and IgM in the group. A total of 844 prison inmates were assessed, 265 of whom tested positive for COVID-19, indicating 31.64% prevalence (95%CI: 28.44-34.83). Statistically significant associations were seen between positive test and location of the prison in the north of the state (p = 0.001), closed imprisonment (p = 0.002), and male gender (p = 0.005). All symptoms were observed less frequently in the group that tested positive, and there was a low prevalence of comorbidities (0 to 7.1%). The results revealed the characteristics of this vulnerable population and can help target health measures.

El objetivo fue estimar el porcentaje de personas privadas de libertad en Espírito Santo, Brasil, infectadas con el SARS-CoV-2 y presentar factores asociados al resultado positivo. Se trata de una encuesta serológica, realizada entre los días 31 de agosto y 4 de septiembre de 2020, en las 34 unidades carcelarias del estado. Se realizó una entrevista y tests serológicos para la detección de IgG e IgM en el grupo estudiado. Se evaluaron a 844 personas privadas de libertad, 265 dieron positivo en COVID-19, indicando una prevalencia de 31,64% (IC95%: 28,44-34,83). Se observó una asociación estadística entre resultado positivo y localización del presidio en la región norte (p = 0,001), régimen de prisión cerrado (p = 0,002) y sexo masculino (p = 0,005). Se destaca incluso que todos los síntomas fueron observados en menor frecuencia en el grupo de los positivos, así como una baja prevalencia de comorbilidades (0 a 7,1%). Los resultados permitieron conocer las características de esa población vulnerable, con el fin de dirigir acciones de salud.

https://doi.org/10.1590/0102-311x00094721

Prevalência de infecção por SARS-CoV-2 e fatores associados em pessoas privadas de liberdade no Espírito Santo, Brasil
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Bianchi, Erika do Nascimento

; Macedo, Laylla Ribeiro

; Maciel, Ethel Leonor Noia

; Sá, Ricardo Tristão

; Silva, Adriana Ilha da

; Duque, Camila Leal Cravo

; Jabor, Pablo Medeiros

; Gomes, Cristiana Costa

; Cardoso, Orlei Amaral

; Lira, Pablo Silva

; Zanotti, Raphael Lubiana

; Magno Filho, Silvânio José de Souza

; Zandonade, Eliana

Cadernos de Saúde Pública

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2022, Volume 38 N. 2 elocation e00094721

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

https://doi.org/10.1590/0102-311x00094721

Yield and profitability responses of cowpea to cropping systems and sowing seasons in Vitória da Conquista, Bahia State, Brazil
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Fogaça, Josué Júnior Novaes Ladeia

; Cairo, Paulo Araquém Ramos

; Cardoso, Adriana Dias

; José, Alcebíades Rebouças São

; Vasconcelos, Ramon Correia de

; Souza, Ubiratan de Oliveira

; Nunes, Renan Thiago Carneiro

Acta Scientiarum. Agronomy

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2022, Volume 44 elocation e53467

Abstract: En | Text: En | PDF: En

ABSTRACT. Cowpea (Vigna unguiculata) crops produce a poor yield in northeastern Brazil compared to the other regions. The goal of this study was to assess the effects of irrigated cropping systems and sowing seasons on cowpea yield and profitability in Vitória da Conquista, Bahia, Brazil. Field studies were performed in four experiments during the rainy and dry seasons during 2016/2017 and 2017/2018, which denoted harvests 1, 2, 3, and 4, respectively. A randomized block design was used for each experiment with four replicates and the following treatments for cropping systems: (1) manual weeding; (2) liming and manual weeding; (3) liming and phosphorus (P) fertilization at sowing, nitrogen (N) and potassium (K) topdressing fertilization, and chemical weed control; (4) liming and P fertilization at sowing, K topdressing fertilization, rhizobia inoculation, and chemical weed control; (5) liming and P fertilization at sowing, N and K topdressing fertilization, rhizobia inoculation, and chemical weed control; and (6) seed pretreatment with cobalt (Co) and molybdenum (Mo), liming and P fertilization at sowing, N and K topdressing fertilization, rhizobia inoculation, and chemical weed control. The technology added to cropping systems increased the number of pods per plant, pod length, seeds per pod, and 100-seed weight, irrespective of the rainy or dry sowing season. Economic analysis, in turn, showed that the technology decreased the total operating cost despite increasing the cost of mechanical operations, inputs, and materials because of the replacement of manual weeding by chemical weed control. However, these costs were not influenced by the sowing seasons. We concluded that technologically enhanced cropping systems, especially systems 4 and 6, improved grain yield and provided greater profitability, which translated into improved economic benefits for farmers. Conversely, the sowing season influenced profitability, which was higher for dry season harvests, when there was less product offered and prices became higher.

https://doi.org/10.4025/actasciagron.v44i1.53467

Chromatographic profile of xanthones and flavonoids in the anti-dengue extracts of Fridericia samydoides (Cham.) L.G. Lohmann (Bignoniaceae)
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Fonseca, Juliane Morais da

; Reis, Adriana Cotta Cardoso

; Pereira, Guilherme Rocha

; Moura, Hélia Maria Marques de

; Souza Filho, José Dias

; Silva, Breno de Mello

; Brandão, Geraldo Célio

Brazilian Journal of Pharmaceutical Sciences

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2022, Volume 58 elocation e18802

Abstract: En | Text: En | PDF: En

Abstract The flavonoids and xanthones present in the ethanol extracts of leaves and stems of Fridericia samydoides showed that anti-dengue activities in vitro were investigated qualitatively by liquid chromatography-ultraviolet-mass spectrometry in series. Nineteen flavones and fifteen xanthones were detected and characterized on the basis of their fragmentation pattern in the positive and negative ion mode tandem mass spectrometry spectra and ultraviolet bands. Acacetin, chrysin, vitexin, isovitexin, orientin, isoorientin, mangiferin, 2’-O-trans-caffeoylmangiferin, 2’-O-trans-coumaroylmangiferin and 2’-O-trans-cinnamoylmangiferin were identified by comparison with authentic samples. The other compounds detected were tentatively assigned by analysis of the spectral data and by comparison with literature reports. In addition, it performed the fractionation of the leaves extract leading to the isolation of mangiferin, isovitexin and isoorientin. All extracts and isolated compounds inhibited the Dengue virus replication cycle with EC50 less than 25.0 µg/mL for extracts and 272.5, 85.6 and 79.3 µg/mL for mangiferin, isovitexin and isoorientin, respectively.

https://doi.org/10.1590/s2175-97902022e18802

10.

Cytotoxic activity of extracts from Tecoma species and isolated lignans
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Reis, Adriana Cotta Cardoso

; Silva, Breno Mello

; Souza Filho, José Dias

; Pereira, Guilherme Rocha

; Brandão, Geraldo Célio

Brazilian Journal of Pharmaceutical Sciences

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2022, Volume 58 elocation e181096

Abstract: En | Text: En | PDF: En

Abstract A phytochemical study of Tecoma genus (Bignoniaceae) was accomplished by antitumor activity of ethanolic extracts. Species of this genus are composed of small shrubs often used as ornamental plants. The Tecoma stans species is used in folk medicine for different purposes. Recent work shows in vitro anticancer activity against human breast cancer. The ethanolic extracts from leaves and trunks of Tecoma casneifolia, T. garrocha, T. stans var. angustata and T. stans var. stans were tested in vitro. The assays used were against line tumor cells by the MTT method and the most active extracts were further studied. In this way, the ethanolic extract from T. stans var. stans trunks presented the higher cytotoxicity against the tumor cell lines studied (CC50 0.02 to 0.55 µg/ml) when compared to the other extracts tested (CC50 0.08 to 200.0 µg/ml). Accordingly, this extract was selected for chromatographic fractionation from which five known lignans were isolated. Further, paulownin, paulownin acetate, sesamin, olivil and cycloolivil were identified using 13C and 1H NMR, IR, UV and spectroscopy and spectrometric MS techniques. These isolated compounds were tested and exhibited CC50 ranging from 13.01 to100.0 µg/ml which is superior to the ethanolic extract of trunk of T. stans.

https://doi.org/10.1590/s2175-97902022e181096

11.

Atualização da Diretriz Brasileira de Hipercolesterolemia Familiar – 2021
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Izar, Maria Cristina de Oliveira

; Giraldez, Viviane Zorzanelli Rocha

; Bertolami, Adriana

; Santos Filho, Raul Dias dos

; Lottenberg, Ana Maria

; Assad, Marcelo Heitor Vieira

; Saraiva, José Francisco Kerr

; Chacra, Ana Paula M.

; Martinez, Tania L. R.

; Bahia, Luciana Ribeiro

; Fonseca, Francisco Antonio Helfenstein

; Faludi, Andre Arpad

; Sposito, Andrei C.

; Chagas, Antônio Carlos Palandri

; Jannes, Cinthia Elim

; Amaral, Cristiane Kovacs

; Araújo, Daniel Branco de

; Cintra, Dennys Esper

; Coutinho, Elaine dos Reis

; Cesena, Fernando

; Xavier, Hermes Toros

; Mota, Isabela Cardoso Pimentel

; Giuliano, Isabela de Carlos Back

; Faria Neto, José Rocha

; Kato, Juliana Tieko

; Bertolami, Marcelo Chiara

; Miname, Marcio Hiroshi

; Castelo, Maria Helane Costa Gurgel

; Lavrador, Maria Sílvia Ferrari

; Machado, Roberta Marcondes

; Souza, Patrícia Guedes de

; Alves, Renato Jorge

; Machado, Valeria Arruda

; Salgado Filho, Wilson

Arquivos Brasileiros de Cardiologia

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oct 2021, Volume 117 N. 4 Pages 782 - 844

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20210788 231 downloads

12.

[SciELO Preprints] - Prevalence of COVID-19 infection in the prison system in Espírito Santo/Brazil: Persons deprived of liberty and justice workers
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Silva, Adriana Ilha da Maciel, Ethel Leonor Noia Duque, Camila Leal Cravo Gomes, Cristiana Costa Bianchi, Erika do Nascimento Cardoso, Orlei Amaral Lira, Pablo Jabor, Pablo Medeiros Zanotti, Raphael Lubiana Sá, Ricardo Tristão Magno Filho, Silvânio José de Souza Zandonade, Eliana

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Publication date: 2021-09-01

Abstract: En Pt

Abstract: Objective: To present a prevalence study in prisons and estimate the percentage of people deprived of liberty, health professionals and prison officers infected with SARS-CoV-2 in ES. Methods: this was a prevalence study with sampling carried out in 34 prison units in ES, stratified between 08/31 and 09/04/2020, based on the Population-based age-stratified seroepidemiological investigation protocol for COVID.19 virus infection. Interviews and rapid tests were carried out to detect IgG and IgM in the groups mentioned. Results: Among the 1,830 individuals (311 health professionals, 675 prison officers and 844 people deprived of liberty - PPL), the prevalence of infection by COVID-19 was 11.89% for health professionals; 22.07% for prison officers and 31.64% for people deprived of liberty. Being mostly male, aged between 21 and 40 years old, with elementary and higher education, and of brown color, the interviewees are concentrated in the Metropolitan Region of Espírito Santo. Conclusions: It was observed that the prevalence was higher among people deprived of liberty in all regions in the closed regime, and for penitentiary officers in the semi-open regime, especially in the North region. As for the comparison between regimens and region, distinctions were observed between groups of PPLs with positive tests. And in order to achieve effectiveness in combating COVID-19 with the prison system, actions of extrication, tests and mass vaccination are necessary, as well as other health actions.

Resumo: Objetivo: Apresentar um estudo de prevalência em presídios e estimar o percentual de pessoas privadas de liberdade, profissionais de saúde e agentes penitenciários infectados com o SARS-CoV-2 no ES. Métodos: tratou-se de um estudo de prevalência com amostragem realizada em 34 unidades prisionais no ES, estratificada entre os dias 31/08 e 04/09/2020, baseado no Population-based age-stratified seroepidemiological investigation protocol for COVID.19 virus infection. Realizou-se entrevistas e testes rápidos para detecção de IgG e IgM nos grupos citados. Resultados: Entre os 1.830 indivíduos (311 profissionais de saúde, 675 agentes penitenciários e 844 pessoas privadas de liberdade - PPL), as prevalências de infecção por COVID-19 foram 11,89% para os profissionais de saúde; 22,07% para os agentes penitenciários e 31,64% para as pessoas privadas de liberdade. Sendo, a maioria do sexo masculino, com idade entre 21 a 40 anos, com ensino fundamental e superior, e de cor parda, concentrando-se os entrevistados na Região Metropolitana do Espírito Santo. Conclusões: Observou-se que a prevalência foi maior entre as pessoas privadas de liberdade em todas as regiões no regime fechado, e para os agentes penitenciários no regime semiaberto, com destaque para a Região Norte. Quanto à comparação entre os regimes e região, observou-se distinções entre quanto aos grupos das PPLs com testes positivos.  E para que se alcance a eficácia no combate a COVID-19 junto ao sistema prisional, são necessárias as ações de desencarceramento, testes e vacinação em massa, como também outras ações de saúde.

https://doi.org/10.1590/1980-549720210053

13.

Posicionamento sobre o Consumo de Gorduras e Saúde Cardiovascular – 2021
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Izar, Maria Cristina de Oliveira

; Lottenberg, Ana Maria

; Giraldez, Viviane Zorzanelli Rocha

; Santos Filho, Raul Dias dos

; Machado, Roberta Marcondes

; Bertolami, Adriana

; Assad, Marcelo Heitor Vieira

; Saraiva, José Francisco Kerr

; Faludi, André Arpad

; Moreira, Annie Seixas Bello

; Geloneze, Bruno

; Magnoni, Carlos Daniel

; Scherr, Carlos

; Amaral, Cristiane Kovacs

; Araújo, Daniel Branco de

; Cintra, Dennys Esper Corrêa

; Nakandakare, Edna Regina

; Fonseca, Francisco Antonio Helfenstein

; Mota, Isabela Cardoso Pimentel

; Santos, José Ernesto dos

; Kato, Juliana Tieko

; Beda, Lis Mie Masuzawa

; Vieira, Lis Proença

; Bertolami, Marcelo Chiara

; Rogero, Marcelo Macedo

; Lavrador, Maria Silvia Ferrari

; Nakasato, Miyoko

; Damasceno, Nagila Raquel Teixeira

; Alves, Renato Jorge

; Roberta Soares, Lara

; Costa, Rosana Perim

; Machado, Valéria Arruda

Arquivos Brasileiros de Cardiologia

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jan 2021, Volume 116 N. 1 Pages 160 - 212

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20201340 9969 downloads

14.

Prevalência de infecção por COVID-19 no sistema prisional no Espírito Santo/Brasil: pessoas privadas de liberdade e trabalhadores da justiça
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Silva, Adriana Ilha da

; Maciel, Ethel Leonor Noia

; Duque, Camila Leal Cravo

; Gomes, Cristiana Costa

; Bianchi, Erika do Nascimento

; Cardoso, Orlei Amaral

; Lira, Pablo

; Jabor, Pablo Medeiros

; Zanotti, Raphael Lubiana

; Sá, Ricardo Tristão

; Magno Filho, Silvânio José de Souza

; Zandonade, Eliana

Revista Brasileira de Epidemiologia

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2021, Volume 24 elocation e210053

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: Objetivo: Apresentar um estudo de prevalência em presídios e estimar o percentual de pessoas privadas de liberdade, profissionais de saúde e agentes penitenciários infectados com o SARS-CoV-2 no Espírito Santo (ES). Métodos: Tratou-se de um estudo de prevalência com amostragem realizada em 34 unidades prisionais no ES, estratificadas entre os dias 31 de agosto e 4 de setembro de 2020, com base no Population-based age-stratified seroepidemiological investigation protocol for COVID-19 virus infection. Realizaram-se entrevistas e testes rápidos para detecção de imunoglobina G e M nos grupos citados. Resultados: Entre os 1.830 indivíduos (311 profissionais de saúde, 675 agentes penitenciários e 844 pessoas privadas de liberdade - PPL), as prevalências de infecção por COVID-19 foram 11,89% para os profissionais de saúde, 22,07% para os agentes penitenciários e 31,64% para as PPL. A maioria era do sexo masculino, com idade entre 21 a 40 anos, ensino fundamental e superior e cor parda, e os entrevistados concentravam-se na Região Metropolitana de Vitória. Conclusão: Observou-se que a prevalência foi maior entre as pessoas privadas de liberdade em todas as regiões no regime fechado e para os agentes penitenciários no regime semiaberto, com destaque para a Região Norte. Quanto à comparação entre os regimes e região, observaram-se distinções entre os grupos das PPL com testes positivos. Para que se alcance a eficácia no combate à COVID-19 no sistema prisional, são necessárias ações de desencarceramento, testes e vacinação em massa, como também outras ações de saúde.

ABSTRACT: Objective : To present a prevalence study held in prisons and estimate the percentage of persons deprived of liberty, health professionals, and prison officers infected with SARS-CoV-2 in Espírito Santo (ES). Methods: This is a prevalence study with a sample from 34 ES prisons, stratified between August 31 and September 4, 2020, following the Population-based age-stratified seroepidemiological investigation protocol for COVID-19 virus infection. The participants were interviewed and underwent rapid tests to detect immunoglobulin G and M in the groups mentioned. Results: Among 1,830 individuals (311 health professionals, 675 prison officers, and 844 persons deprived of liberty - PDL), the prevalence of COVID-19 infection was 11.89% for health professionals, 22.07% for prison officers, and 31.64% for PDL. Most interviewees were male, aged 21 to 40 years, had completed elementary school and higher education, were multiracial, and situated in the Metropolitan area of Vitória. Conclusion : The prevalence was higher among persons deprived of liberty in the closed regime in all regions, as well as prison officers working in the semi-open regime, particularly in the North region. As for the comparison between regimes and regions, differences were identified between PDL groups with positive test results. Effectively combating COVID-19 within the prison system requires prison release actions, testing, and mass vaccination, as well as other health actions.

https://doi.org/10.1590/1980-549720210053

15.

Prevalência de infecção por COVID-19 no sistema prisional no Espírito Santo/Brasil: pessoas privadas de liberdade e trabalhadores da justiça
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Silva, Adriana Ilha da

; Maciel, Ethel Leonor Noia

; Duque, Camila Leal Cravo

; Gomes, Cristiana Costa

; Bianchi, Erika do Nascimento

; Cardoso, Orlei Amaral

; Lira, Pablo

; Jabor, Pablo Medeiros

; Zanotti, Raphael Lubiana

; Sá, Ricardo Tristão

; Magno Filho, Silvânio José de Souza

; Zandonade, Eliana

Revista Brasileira de Epidemiologia

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2021, Volume 24 elocation e210053

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1980-549720210053

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