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ABSTRACT Campomanesia adamantium (Cambess.) O. Berg (guavira) is a native plant of the Cerrado and Pantanal, which has several medicinal activities and fruits with a unique flavor rich in vitamin C. The species does not have defined cultivation methods, requiring studies to increase biomass production. An alternative is the use of organic residues that can influence the chemical, physical and biological characteristics of soils and consequently increase plant production. Thus, the objective was to evaluate the effect of different organic residues and bokashi, on the biomass production of plants and on the levels of phenols, flavonoids and antioxidant activity of tea from the leaves of guavira. Five substrates were studied in pots and protected environment: soil; soil + rice husk chicken manure; soil + sawdust chicken manure; soil + castor bean cake; soil + Organosuper® with or without the use of Bokashi in a 5x2 factorial scheme, in a randomized block experimental design. It was observed that the rice husk chicken manure can be used to increase the initial growth and biomass production of guavira keeping the leaves antioxidant activity tea stable. The use of bokashi benefits the growth of guavira only when no other organic residue is added to soil.

https://doi.org/10.1590/0034-737x202370030007

A Multi-Plasmonic Approach for Simultaneous Measurements based on a D-Shaped Photonic Crystal Fiber Sensor: from Temperature to Optical Dispersion MultiPlasmonic Multi Plasmonic DShaped D Shaped Sensor
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Romeiro, Amanda F.

; Cardoso, Markos P.

; Silva, Anderson O.

; Costa, João C. W. A.

; Giraldi, M. Thereza R.

; Santos, José L.

; Baptista, José M.

; Guerreiro, Ariel

Journal of Microwaves, Optoelectronics and Electromagnetic Applications

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mar 2023, Volume 22 N. 1 Pages 219 - 229

Abstract: En | Text: En | PDF: En

Abstract The growing demand for multiparameter sensors includes compact devices accompanied by simple calibration processes to distinguish the outputs from each other. This paper evaluates a scheme to determine multiple parameters of a medium using localized surface plasmon resonances (SPR) excited on a Dshaped photonic crystal fiber (PCF) partially covered by two gold layers of different thicknesses. We demonstrate that the proposed sensing platform, once customized to characterize the possible dispersive profiles of the refractive index of the analyte, also allows interrogating the temperature of a sample from a linear relationship. Since the plasmonic resonances are excited at separated and low crosstalk spectral channels, different sensing responses can be obtained simultaneously in the same location of the D-shaped PCF. These features turn out the SPR sensor a suitable tool for simultaneous monitoring of optical dispersion and temperature. other (SPR PCF (PCF thicknesses platform analyte relationship channels D shaped

https://doi.org/10.1590/2179-10742023v22i1270778

Agronomic parameters of sugarcane under planting densities in different cultivation cycles
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Costa, J. E.

; Silva, J. H. B.

; Silva, I. D. N.

; Silva, G. M. L.

; Nascimento, R. R. A.

; Silva, J. S. L.

; Barbosa, J. M. S.

; Cardoso, E. V. B.

; Silva, A. V.

; Nascimento, M. A.

; Santos, J. P. O.

; Martins, A. H. P. C.

; Pereira Neto, F.

; Amorim, P. M. D.

; Silva, B. O. T.

; Almeida, L. J. M.

; Mielezrski, F.

Brazilian Journal of Biology

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2023, Volume 83 elocation e278007

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Low density sugarcane plantation (LDSP) has been implemented by some sugarcane producers in Brazil, aiming to save seeds and operational costs. The study was carried out in the municipality of Areia, Paraíba, Brazil. Five planting densities were used, varying from 5 to 25 m-2 of buds arranged in randomized blocks, with four replications. Data were measured annually over three cultivation cycles (2017 to 2020), during which the field was fertilized with NPK and the harvests were carried out manually without prior burning. The lower planting density presents higher productivity only in the cane plant (101.03 t ha-1) due to the higher plant height (2.37 m) and the higher number of stalks (11 stalks m-2), suggesting that these variables are due to the greater availability of light, water and photosynthate. However, there is a drastic reduction in sugarcane yield for this lower population in the 2nd ratoon by up to 65.62%, which is correlated with number of stalks per meter. We demonstrate the agronomic viability of LDSP in the population of 10 buds m-2 in relation to conventional planting of sugarcane until the 2nd ratoon. Data are important for future studies to present additional considerations for other production factors, such as the effects of mechanized harvesting and the management of nutrients and water, assessing the sustainability of this large-scale planting system.

Resumo O método de plantio de cana-de-açúcar de baixa densidade (LDSP) vem sendo implementado por alguns produtores de cana-de-açúcar no Brasil, visando economia de sementes e custos operacionais. O estudo foi realizado no município de Areia, Paraíba, Brasil. Utilizou-se cinco densidades de plantio, variando de 5 a 25 m-2 de gemas dispostas em blocos casualizados, com quatro repetições. Os dados foram medidos anualmente ao longo de três ciclos de cultivo (2017 a 2020). Menor densidade de plantio mostrou maior produtividade (101,03 t ha-1) devido à maior altura de planta (2,37 m) e ao maior número de hastes (NS) (11 hastes m-2), sugerindo que essas variáveis são devido à maior disponibilidade de luz, água e fotoassimilados. No entanto, houve redução drástica na produtividade da cana-de-açúcar para esta população menor na 2ª soca em 65,62%, estando correlacionado com o número de colmos por metro. Demonstramos a viabilidade agronômica do LDSP em uma população de 10 gemas m-2 em relação ao plantio convencional de cana-de-açúcar até a 2ª soca. Os dados são importantes para que estudos futuros apresentem considerações adicionais sobre outros fatores de produção, como os efeitos da colheita mecanizada e do manejo de nutrientes e água, avaliando a sustentabilidade desse sistema de plantio em larga escala.

https://doi.org/10.1590/1519-6984.278007

Art and science: impact of semioccluded vocal tract exercises and choral singing on quality of life in subjects with congenital GH deficiency
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Andrade, Bruna M. R. de

; Valença, Eugenia H. O.

; Salvatori, Roberto

; Oliveira Neto, Luiz A.

; Souza, Anita H. O.

; Oliveira, Alaíde H. A.

; Oliveira, Mario C.P.

; Melo, Enaldo V.

; Carvalho, Susana de

; Sales, Neuza J

; Monteiro, Gisane C.

; Lima, José Marcel de

; Annunziato, Marcos Felipe Harder

; Mannis, Guilherme Daniel Breternitz

; Souza, Lucas E. de A.

; Goes, Yasmin D.

; Carvalho, Thayza S.

; Farias, Celiane de

; Santos, Michela P. dos

; Cardoso, Gabriela P. F.

; Sousa, Carla S. Pereira

; Santana, Julia Rodrigues

; Sales, Ester Almeida

; d’Avila, Jeferson Sampaio

; Aguiar-Oliveira, Manuel H.

Archives of Endocrinology and Metabolism

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apr 2022, Volume 66 N. 2 Pages 198 - 205

Abstract: En | Text: En | PDF: En

ABSTRACT Objectives: Currently, not much is known about the interactions between voice and growth hormone (GH). We have described large kindred with isolated GH deficiency (IGHD) due to a GHRH receptor mutation, resulting in severe short stature and high-pitched voice. These IGHD individuals have little interest in GH treatment, as they consider themselves “short long-lived people”, rather than patients. Interestingly, they report normal general quality of life, but they rate their Voice-Related Quality of Life (V-RQOL) as low. Here, we assessed the social and auditory-perceptual impacts of artistic-intervention voice therapy with semioccluded vocal tract exercises (SOVTE) and choral singing, on their voices. Material and methods: Seventeen GH-naïve adult IGHD individuals were enrolled in a single-arm interventional pre-post study with 13 weekly sessions of choir singing over 90 days. Outcome measures were V-RQOL scores, self-assessment of voice, and auditory-perceptual analysis (GRBAS scale, G: grade of the severity of dysphonia; R: roughness; B: breathiness; A: asthenia; and S: strain). Results: Marked improvements in total (p = 0.0001), physical (p = 0.0002), and socioemotional (p = 0.0001) V-RQOL scores and in self-assessment of voice (p = 0.004) were found. The general grades of vocal deviation (p = 0.0001), roughness (p = 0.0001), breathiness (p = 0.0001) and strain (p = 0.0001) exhibited accentuated reductions. Conclusions: Voice therapy with semioccluded vocal tract exercises and choral training improved social impact and perceptual voice assessments in IGHD subjects and markedly improved their voice-related quality of life. This is particularly important in a setting where GH replacement therapy is not widely accepted.

https://doi.org/10.20945/2359-3997000000449

Photoprotective action, anti-oxidant activity, and toxicity of aqueous extracts of Campomanesia sessiliflora O. Berg
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Aguayo-de-Castro, Thiago Luis

; Ferreira-Duarte, Bianca

; Lima-Cardoso, Claudia Andrea

Revista Colombiana de Química

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dec 2021, Volume 50 N. 3 Pages 10 - 15

Abstract: Es En Pt | Text: Es En Pt | PDF: Es | PDF: En | PDF: Pt

Resumen Campomanesia sessiliflora O. Berg es una planta medicinal que tiene pocos estudios en la literatura. En este contexto, se analizó la actividad antioxidante, factor de protección solar (FPS) y toxicidad en lixiviados de Artemia salina, así como el contenido de compuestos fenólicos, flavonoides y taninos en extractos acuosos preparados por infusión y maceración de hojas de C. sessiliflora. La maceración mostró niveles más altos de compuestos fenólicos y flavonoides, en relación con la infusión, y las dos muestras tuvieron el mismo contenido de taninos. La DL50 fue similar para los extractos, considerándose ambas muestras de baja toxicidad en el ensayo con A. salina. La infusión presentó un FPS de 9,98, mientras que la maceración tuvo un FPS de 6,74. La maceración mostró niveles más altos de metabolitos secundarios y actividad antioxidante y la infusión mostró un mejor FPS. Los extractos muestran potencial para incorporarse a productos multifuncionales.

Abstract Campomanesia sessiliflora O. Berg is a medicinal plant that is object of very few studies in the literature. In this context, the antioxidant activity, sun protection factor (SPF) and toxicity in Artemiasalina Leachs were analysed, as well as the contents of phenolic compounds, flavonoids and tannins in aqueous extracts prepared by infusion and maceration of C. sessiliflora leaves. Maceration showed higher levels of phenolic compounds and flavonoids regarding infusion and the two samples had the same tannin content. The LD50 was similar for the extracts, both were considered as low toxicity in the test with A. salina. Infusion presented a SPF of 9.98, while maceration presented a SPF of 6.74. Maceration presented better contents of secondary metabolites and antioxidant activity and infusion presented a better SPF. The extracts have the potential of incorporation into multifunctional products.

Resumo Campomanesia sessiliflora O. Berg é uma planta medicinal que apresenta poucos estudos na literatura. Neste contexto, foram analisados a atividade antioxidante, fator de proteção solar (FPS) e toxicidade em Artemia salina Leachs, assim como os teores de compostos fenólicos, flavonoides e taninos dos extratos aquosos preparados por infusão e maceração das folhas de C. sessiliflora. A maceração apresentou maior teores de compostos fenólicos e flavonoides em relação a infusão e as duas amostras apresentaram o mesmo teor de taninos. O DL50 foi semelhante para os extratos, ambas amostras sendo consideradas como baixa toxicidade no ensaio com A. salina. A infusão apresentou FPS de 9,98, enquanto que a maceração o FPS foi de 6,74. A maceração apresentou maiores teores de metabólitos secundários e atividade antioxidante e a infusão apresentou melhor FPS. Os extratos apresentam potencial para a incorporação em produtos multifuncionais.

https://doi.org/10.15446/rev.colomb.quim.v50n3.97095 68 downloads

Genetic parameters and selection of biofortified lettuce genotypes based on selection indices
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Sousa, Luciana A. de

; Maciel, Gabriel M.

; Juliatti, Fernando C.

; Beloti, Igor F.

; Cardoso, Daniel B. O.

; Siquieroli, Ana C. S.

Revista Brasileira de Engenharia Agrícola e Ambiental

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nov 2021, Volume 25 N. 11 Pages 772 - 778

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO A obtenção de vegetais biofortificados, com destaque para a alface, é uma ferramenta para melhorar o estado nutricional da população. Os índices de seleção podem maximizar a seleção simultânea de boas características agronômicas e altos níveis de carotenoides. O objetivo deste estudo foi estimar os parâmetros genéticos e a eficiência de diferentes índices para a seleção de genótipos de alface biofortificados combinados com características agronômicas adequadas. As análises estatísticas foram realizadas com 91 genótipos pertencentes ao banco de germoplasma de alface biofortificada da Universidade Federal de Uberlândia. As variáveis analisadas foram: índice de clorofila das folhas, diâmetro da planta, diâmetro do caule e número de folhas por planta. Os valores encontrados para herdabilidade no sentido restrito (h²) variaram de 89,63% (diâmetro do caule) a 96,05% (clorofila), apresentando alta magnitude. O índice de Smith-Hazel, a soma de “ranks” de Mulamba & Mock, a seleção direta e indireta e o índice base de Williams foram usados para prever os ganhos de seleção. No total, 17 indivíduos foram selecionados usando as metodologias de seleção. Os índices de Smith-Hazel, Williams e Mulamba & Mock são eficientes em mostrar bons ganhos diretos para as características avaliadas. Treze genótipos foram selecionados por todos os índices apresentando características agronômicas favoráveis, sendo promissores para o avanço de geração no programa de melhoramento para obter linhagens de alface biofortificadas.

ABSTRACT Obtaining biofortified vegetables with an emphasis on lettuce is a tool to improve the nutritional status of the population. Selection indices can maximize the simultaneous selection of good agronomic traits and high carotenoid levels. The objective of this study was to estimate the genetic parameters and efficiency of different indices in selecting genotypes of biofortified lettuce with high concentrations of carotenoids and favorable agronomic traits. Statistical analyses were performed on 91 genotypes belonging to the vegetable germplasm bank of the Federal University of Uberlândia, Brazil. The variables analyzed were the chlorophyll index of the leaves, plant diameter, stem diameter, and number of leaves per plant. The values found for narrow sense heritability (h²) ranged from 89.63% (stem diameter) to 96.05% (chlorophyll), showing a high magnitude. The Smith-Hazel index, sum of ranks by the Mulamba & Mock index, direct and indirect selection, and Williams base index were used to predict the selection gains. A total of 17 individuals were selected using the selection methodologies. The Smith-Hazel, Williams, and Mulamba & Mock indices were efficient in showing good direct gains for the evaluated traits. Thirteen genotypes were selected for all indices presenting suitable agronomic traits, which show promise for advancing generations within the breeding program to obtain biofortified lettuce strains.

https://doi.org/10.1590/1807-1929/agriambi.v25n11p772-778 86 downloads

Synthesis of brushite/polyethylene glycol cement for filler in bone tissue injuries
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Morúa, O. C.

; Cardoso, M. J. B.

; Silva, H. N. da

; Carrodeguas, R. G.

; Rodríguez, M. A.

; Fook, M. V. L.

Cerâmica

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sep 2021, Volume 67 N. 383 Pages 289 - 294

Abstract: En | Text: En | PDF: En

Abstract The objective of this work was to produce brushite cement for orthopedic applications, based on the system wollastonite/phosphoric acid with the incorporation of polyethylene glycol (PEG) as a setting and processing additive. Brushite/PEG cement was obtained by the dissolution-precipitation method and its physicochemical properties were characterized by X-ray diffraction, compressive strength, porosimetry, and biological behavior (cell adhesion and bioactivity tests). The results indicated the formation of brushite cement with 21.4 MPa of compressive strength and 30% porosity, similar to human trabecular bone. The surface was shown to be adequate for cell adhesion and growth and bioactive with the formation of apatite layers. The incorporation of PEG improved working conditions without causing undesirable changes in the physicochemical properties and biological behavior of developed cement, thus promising for the repair of bone tissue injuries.

https://doi.org/10.1590/0366-69132021673833054 58 downloads

Bergenin of Peltophorum dubium (Fabaceae) Roots and Its Bioactive Semi-Synthetic Derivatives
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Silva Neto, Oscar C. da

; Teodoro, Marla T. F.

; Nascimento, Bruna O. do

; Cardoso, Klauber V.

; Silva, Eliane O.

; David, Jorge M.

; David, Juceni P.

Journal of the Brazilian Chemical Society

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dec 2020, Volume 31 N. 12 Pages 2644 - 2650

Abstract: En | Text: En | PDF: En

This work describes the isolation of pure bergenin from Peltophorum dubium roots with good yields and its further derivatization through Williamson synthesis. The alkyl derivatives of the bergenin were identified by nuclear magnetic resonance and mass spectrometry data analysis. Among them, three derivatives were reported for the first time herein, 8,10-dihexyl-bergenin, 8,10-didecyl-bergenin, and 8,10-ditetradecyl-bergenin, along with three previously reported ones (8,10-dimethylbergenin, 8-methylbergenin, 8,10-dioctyl-bergenin). Most derivatives of the bergenin displayed moderate cytotoxicity against Artemia salina, except the 8,10-dihexyl-bergenin (lethal concentration doses for 50% (LC50) = 70.55 µg mL-1). The antimicrobial assay showed that all derivatives selectively inhibited the Gram-positive bacteria Staphylococcus aureus, and two of them (8,10-dihexyl-bergenin and 8,10-didecyl-bergenin) had promising activities (minimum inhibitory concentration (MIC) = 5.1-6.2 µmol L-1). In addition, bergenin displayed interesting inhibition on acetylcholinesterase (half maximal inhibitory concentration (IC50) = 141.19 ± 0.41 µmol L-1), while its semi-synthetic derivatives displayed modest activity. Our results revealed that the antibacterial activity of bergenin could be greatly improved through its structural modification.

https://doi.org/10.21577/0103-5053.20200141 226 downloads

CONSTRUÇÃO DE UM SUPORTE AJUSTÁVEL LAB-MADE IMPRESSO EM 3D PARA MEDIÇÃO DE ÂNGULO DE CONTATO
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Silva, Vinicius A. O. P. da

; Tartare, Vinicius A. P.

; Kalinke, Cristiane

; Oliveira, Paulo Roberto de

; Souza, Daniel Cardoso de

; Bonacin, Juliano A.

; Janegitz, Bruno C.

Química Nova

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sep 2020, Volume 43 N. 9 Pages 1312 - 1319

Abstract: Pt | Text: Pt | PDF: Pt

Advances in the use of 3D printing technology have led to the development of new low-cost devices. This technology features high versatility, considering the easy modulation of the materials depending on its objectives and applications. In this sense, we have developed a laboratory-built contact angle measuring device (lab-made). The device was composed by the assembly of 26 3D-printed pieces of different sizes and design printed using acrylonitrile-butadiene-styrene polymer. The device was designed in three main parts. The first part was related to the analysis, with the use of platforms for the sample surfaces positioning. The second part was made to support a micropipette, prepared to add the drop for analysis; and the third for the support of a smartphone, utilized to obtain the images. The device was applied for the measurement of contact angle on different surfaces, demonstrating its versatility and precision of the results. The obtained values are in accordance with others found in the literature. The developed device presented a low-cost (US$ 25.34 per device), easy assembly and operation.

https://doi.org/10.21577/0100-4042.20170624 519 downloads

10.

Relationship between Electrochemical Parameters, Cytotoxicity Data against Cancer Cells of 3-Thio-Substituted Nor-Beta-Lapachone Derivatives. Implications for Cancer Therapy
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Paiva, Yen G. de

; Silva, Thaissa L.

; Xavier, André F. A.

; Cardoso, Mariana F. C.

; Silva, Fernando C. da

; Silva, Maria F. S.

; Pinheiro, Daniel P.

; Pessoa, Claudia

; Ferreira, Vitor F.

; Goulart, Marilia O. F.

Journal of the Brazilian Chemical Society

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mar 2019, Volume 30 N. 3 Pages 658 - 672

Abstract: En | Text: En | PDF: En

Electrochemical methods are powerful in the characterization and design of redox-modulating agents. We, herein, report the electrochemical investigation, in aprotic medium, of eleven synthetic 3-thio-substituted-nor-beta-lapachones, along with the determination of cytotoxic activity and correspondent selectivity index, against several cancer cell lines and one normal cell. Four of the quinones are novel compounds. The redox behavior is representative of two independent systems: the easy reduction of the quinone moiety and, at far more negative potential, the reductive cleavage of the C-S-C bonding; and the anodic part controlled by the oxidation of the sulfur moiety. The compounds have shown relevant cytotoxic activity, with emphasis on 3-phenyl-thio-2,2-dimethyl-2,3-dihydronaphtho[1,2-b]furan-4,5-dione (compound 2), which mechanism of molecular action was shown to be related to reactive oxygen species (ROS) release. Despite the absence of a linear correlation, there is a trend: the majority of the thionaphthoquinones, with values of first wave reduction potential, less negative than -0.65 V, were active. The less electrophilic compound (3-(cyclohexylthio)-2,2-dimethyl-2,3-dihydronaphtho[1,2-b]furan-4,5-dione, cyclohexyl derivative) is also the less cytotoxic toward cancer cells. Agents containing chalcogens and quinones can be used to attack entities with a disturbed redox balance.

https://doi.org/10.21577/0103-5053.20180248 741 downloads

11.

Where do we aspire to publish? A position paper on scientific communication in biochemistry and molecular biology
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Baptista, M.S.

; Alves, M.J.M.

; Arantes, G.M.

; Armelin, H.A.

; Augusto, O.

; Baldini, R.L.

; Basseres, D.S.

; Bechara, E.J.H.

; Bruni-Cardoso, A.

; Chaimovich, H.

; Colepicolo Neto, P.

; Colli, W.

; Cuccovia, I.M.

; Da-Silva, A.M.

; Di Mascio, P.

; Farah, S.C.

; Ferreira, C.

; Forti, F.L.

; Giordano, R.J.

; Gomes, S.L.

; Gueiros Filho, F.J.

; Hoch, N.C.

; Hotta, C.T.

; Labriola, L.

; Lameu, C.

; Machini, M.T.

; Malnic, B.

; Marana, S.R.

; Medeiros, M.H.G.

; Meotti, F.C.

; Miyamoto, S.

; Oliveira, C.C.

; Souza-Pinto, N.C.

; Reis, E.M.

; Ronsein, G.E.

; Salinas, R.K.

; Schechtman, D.

; Schreier, S.

; Setubal, J.C.

; Sogayar, M.C.

; Souza, G.M.

; Terra, W.R.

; Truzzi, D.R.

; Ulrich, H.

; Verjovski-Almeida, S.

; Winck, F.V.

; Zingales, B.

; Kowaltowski, A.J.

Brazilian Journal of Medical and Biological Research

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2019, Volume 52 N. 9 elocation e8935

Abstract: En | Text: En | PDF: En

The scientific publication landscape is changing quickly, with an enormous increase in options and models. Articles can be published in a complex variety of journals that differ in their presentation format (online-only or in-print), editorial organizations that maintain them (commercial and/or society-based), editorial handling (academic or professional editors), editorial board composition (academic or professional), payment options to cover editorial costs (open access or pay-to-read), indexation, visibility, branding, and other aspects. Additionally, online submissions of non-revised versions of manuscripts prior to seeking publication in a peer-reviewed journal (a practice known as pre-printing) are a growing trend in biological sciences. In this changing landscape, researchers in biochemistry and molecular biology must re-think their priorities in terms of scientific output dissemination. The evaluation processes and institutional funding for scientific publications should also be revised accordingly. This article presents the results of discussions within the Department of Biochemistry, University of São Paulo, on this subject.

https://doi.org/10.1590/1414-431x20198935 1769 downloads

12.

Lemierre's syndrome leading to cerebral venous thrombosis
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Martinez, Alberto R. M.

; Martins Jr, Carlos Roberto

; Resende, Lucas N. De

; Cardoso, Tânia A. M. O.

; Reis, Fabiano

; França Jr, Marcondes C.

Arquivos de Neuro-Psiquiatria

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may 2018, Volume 76 N. 5 Pages 358 - 358

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/0004-282x20180029 1330 downloads

13.

Diagnostic utility of DREAM gene mRNA levels in thyroid tumours
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Batista, Fernando A.

; Marcello, Marjory A.

; Martins, Mariana B.

; Peres, Karina C.

; Cardoso, Ulieme O.

; Silva, Aline C. D. N.

; Bufalo, Natassia E.

; Soares, Fernando A.

; Silva, Márcio J. da

; Assumpção, Lígia V.

; Ward, Laura S.

Archives of Endocrinology and Metabolism

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mar 2018, Volume 62 N. 2 Pages 205 - 211

Abstract: En | Text: En | PDF: En

ABSTRACT Objective The transcriptional repressor DREAM is involved in thyroid-specific gene expression, thyroid enlargement and nodular development, but its clinical utility is still uncertain. In this study we aimed to investigate whether DREAM mRNA levels differ in different thyroid tumors and how this possible difference would allow the use of DREAM gene expression as molecular marker for diagnostic and/or prognosis purpose. Materials and methods We quantified DREAM gene mRNA levels and investigated its mutational status, relating its expression and genetic changes to diagnostic and prognostic features of 200 thyroid tumors, being 101 malignant [99 papillary thyroid carcinomas (PTC) and 2 anaplastic thyroid carcinomas] and 99 benign thyroid lesions [49 goiter and 50 follicular adenomas (FA)]. Results Levels of mRNA of DREAM gene were higher in benign (0.7909 ± 0.6274 AU) than in malignant (0.3373 ± 0.6274 AU) thyroid lesions (p < 0.0001). DREAM gene expression was able to identify malignancy with 66.7% sensitivity, 85.4% specificity, 84.2% positive predictive value (PPV), 68.7% negative predictive value (NPV), and 75.3% accuracy. DREAM mRNA levels were also useful distinguishing the follicular lesions FA and FVPTC with 70.2% sensitivity, 73.5% specificity, 78.5% PPV, 64.1% NPV, and 71.6% accuracy. However, DREAM gene expression was neither associated with clinical features of tumor aggressiveness, nor with recurrence or survival. Six different genetic changes in non-coding regions of DREAM gene were also found, not related to DREAM gene expression or tumor features. Conclusion We suggest that DREAM gene expression may help diagnose thyroid nodules, identifying malignancy and characterizing follicular-patterned thyroid lesions; however, it is not useful as a prognostic marker.

https://doi.org/10.20945/2359-3997000000028 855 downloads

14.

Produção e qualidade de sementes de feijão-caupi em função de doses de molibdénio e da população de plantas
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Nunes, Renan Thiago C.

; Souza, Ubiratan O.

; Neto, Aderson C. Araujo

; Morais, Otoniel M.

; Fogaça, Josué Júnior N. L.

; Santos, Jerffson L.

; Cardoso, Adriana D.

; José, Alcebíades R. São

Revista de Ciências Agrárias

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sep 2017, Volume 40 N. 3 Pages 533 - 542

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

A população de plantas e a adubação com micronutrientes influenciam diretamente o comportamento do feijão-caupi(Vigna unguiculata (L.) Walp.), e dependem das condições de plantação, das características morfológicas e fisiológicas e da capacidade produtiva das cultivares, resultando, assim, na produção de sementes de alta qualidade. Nesse sentido, o objetivo deste trabalho foi verificar os efeitos de doses de molibdénio e densidades de plantas na produção e qualidade de sementes de feijão-caupi, cultivar BRS Novaera. O delineamento experimental foi em blocos casualizados, com quatro repetições, sendo os tratamentos dispostos em esquema fatorial 4 x 4, envolvendo quatro doses de molibdénio aplicadas via semente (0, 40, 80 e 120 g.ha-1) e quatro densidades populacionais (100, 160, 220 e 280 mil plantas.ha-1). Após a colheita, determinou-se a produtividade e as sementes foram submetidas às seguintes avaliações: teor de humidade, massa de mil sementes, germinação, emergência de plântulas, índice de velocidade de emergência, comprimento e massa seca da parte aérea de plântulas. A aplicação de doses de molibdénio via sementes não afetou a produção e a qualidade das sementes da cultivar. Entretanto, o aumento da densidade de plantas por hectare promoveu acréscimos significativos na produtividade e na massa de mil sementes.

The plant population density and fertilization with micronutrients directly influence the cowpea Vigna unguiculata (L.) Walp. performance, depending on the growing conditions, the morphological and physiological characteristics, and productive capacity of the cultivars thus affecting the quality of seeds. The aim of this study is to evaluate the effects of doses of molybdenum and plant density on the yield and quality of cowpea seeds, cultivar BRS Novaera. Randomized block design with four replications was used, with the treatments being 4 x 4 factorial, involving four molybdenum rates applied to seeds (0, 40, 80 and 120 g.ha-1) and four population densities (100, 160, 220 and 280 thousand plants.ha-1). After harvesting, productivity was determined, and the seeds were submitted to the following evaluations: moisture content, mass of one thousand seeds, germination, seedling emergence, emergence speed index, length and dry mass of shoot. The application of molybdenum to seeds did not affect production and the quality of the seeds. However, the increase in plant population density led to significant increases in productivity and mass of a thousand seeds.

https://doi.org/10.19084/RCA17028 1845 downloads

15.

COCRISTAIS: UMA ESTRATÉGIA PROMISSORA NA ÁREA FARMACÊUTICA
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Rocha, Alanny B. O.

; Kuminek, Gislaine

; Machado, Tatiane C.

; Rosa, Juliana

; Rauber, Gabriela S.

; Borba, Paola A. A.

; Siedler, Sana

; Stulzer, Hellen K.

; Cuffini, Silvia Lucia

; Rodríguez-Hornedo, Naír

; Cardoso, Simone G.

Química Nova

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nov 2016, Volume 39 N. 9 Pages 1112 - 1125

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Pharmaceutical cocrystals have emerged as a useful strategy to improve the aqueous solubility of poorly water soluble drugs by aiming to enhance their oral absorption and bioavailability. Aqueous cocrystal solubility can be orders of magnitude higher than that of the constituent drug and this solubility advantage can be fine-tuned based on environmental conditions such as pH and the presence of drug solubilizing agents. This review presents a brief overview of pharmaceutical cocrystals regarding cocrystal design, obtainment methods, with particular focus on cocrystal solubility, and the solubility modulation by solution phase chemistry.

https://doi.org/10.21577/0100-4042.20160139 3268 downloads

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