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RESUMO O gerenciamento do lodo de esgoto é um dos principais responsáveis pelos elevados custos de operação de estações de tratamento de esgoto no Brasil. Isso se deve, principalmente, pela necessidade de etapas de desaguamento e higienização desse material, sendo essa última realizada quando o uso agrícola do lodo é escolhido como forma de destinação. Para tentar reduzir os custos e melhorar o gerenciamento do lodo em uma estação de tratamento de esgoto, uma opção que vem sendo amplamente discutida é o aproveitamento do biogás, produzido em reatores anaeróbios de fluxo ascendente de manta de lodo, para a secagem térmica do lodo. Nesse contexto, o presente trabalho vem relatar um estudo sobre a secagem térmica, de diferentes tipos de lodos, em um sistema piloto envolvendo o aproveitamento energético do biogás produzido em reatores anaeróbios de fluxo ascendente de manta de lodo, de uma estação de tratamento de esgoto de médio porte. O secador reduziu em aproximadamente 80% a massa dos diferentes tipos de lodos submetidos ao processo de secagem térmica, aumentando a concentração de sólidos totais nesses materiais de 20 para 80%. Os valores da demanda energética do secador para remoção de 1 kg de água presente nos diferentes tipos de lodos variaram de 1.195 a 1.323 kcal. Adicionalmente, as características microbiológicas dos diferentes tipos de lodos, após o processo de secagem, evidenciaram a possibilidade da utilização agrícola desses materiais. Esses resultados apontam a secagem térmica do lodo, utilizando biogás produzido em sistemas anaeróbios de tratamento, como uma promissora ferramenta para a sustentabilidade no setor de esgotamento sanitário brasileiro.

ABSTRACT The management of sewage sludge is one of the main responsible for the high operating costs of sewage treatment plants in Brazil. This is mainly due to the need for dewatering and sanitizing steps for this material, being the last one carried out when the agricultural use of the sludge is chosen as a form of destination. To try to reduce costs and improve sludge management at a sewage treatment plant, an option that has been widely discussed is the use of biogas, produced in upflow anaerobic sludge blanket reactors, for the thermal drying of sludge. In this context, the present work reports a study on the thermal drying of different types of sludge, in a pilot system, involving the energy utilization of biogas produced in upflow anaerobic sludge blanket reactors, of a medium-sized sewage treatment plant. The dryer reduced the mass of the different types of sludge subjected to the thermal drying process by approximately 80%, increasing the concentration of total solids in these materials from 20 to 80%. The energy demand values of the dryer to remove 1 kg of water present in the different types of sludge ranged from 1,195 to 1,323 kcal. Additionally, the microbiological characteristics of the different types of sludge, after the drying process, showed the possibility of agricultural use of these materials. These results point to the thermal drying of sludge, using biogas produced in anaerobic treatment systems, as a promising tool for sustainability in the Brazilian sewage sector.

https://doi.org/10.1590/s1413-415220200286

Brazilian recommendations for the use of nonsteroidal anti-inflammatory drugs in patients with axial spondyloarthritis
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Lage, Ricardo da Cruz

; Marques, Claudia Diniz Lopes

; Oliveira, Thauana Luiza

; Resende, Gustavo Gomes

; Kohem, Charles Lubianca

; Saad, Carla Gonçalves

; Ximenes, Antônio Carlos

; Gonçalves, Célio Roberto

; Bianchi, Washington Alves

; Meirelles, Eduardo de Souza

; Keiserman, Mauro Waldemar

; Chiereghin, Adriano

; Campanholo, Cristiano Barbosa

; Lyrio, André Marun

; Schainberg, Cláudia Goldenstein

; Pieruccetti, Lenise Brandao

; Yazbek, Michel Alexandre

; Palominos, Penelope Esther

; Goncalves, Rafaela Silva Guimarães

; Assad, Rodrigo Luppino

; Bonfiglioli, Rubens

; Lima, Sônia Maria Alvarenga Anti Loduca

; Carneiro, Sueli

; Azevedo, Valderílio Feijó

; Albuquerque, Cleandro Pires

; Bernardo, Wanderley Marques

; Sampaio-Barros, Percival Degrava

; Pinheiro, Marcelo de Medeiros

Advances in Rheumatology

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2021, Volume 61 elocation 4

Abstract: En | Text: En | PDF: En

Abstract Spondyloarthritis (SpA) is a group of chronic inflammatory systemic diseases characterized by axial and/or peripheral joints inflammation, as well as extra-articular manifestations. Over some decades, nonsteroidal anti-inflammatory drugs (NSAIDs) have been the basis for the pharmacological treatment of patients with axial spondyloarthritis (axSpA). However, the emergence of the immunobiologic agents brought up the discussion about the role of NSAIDs in the management of these patients. The objective of this guideline is to provide recommendations for the use of NSAIDs for the treatment of axSpA. A panel of experts from the Brazilian Society of Rheumatology conducted a systematic review and meta-analysis of randomized clinical trials for 15 predefined questions. The Grading of Recommendations, Assessment, Development and Evaluation methodology to assess the quality of evidence and formulate recommendations were used, and at least 70% agreement of the voting panel was needed. Fourteen recommendations for the use of NSAIDs in the treatment of patients with axSpA were elaborated. The purpose of these recommendations is to support clinicians’ decision making, without taking out his/her autonomy when prescribing for an individual patient.

https://doi.org/10.1186/s42358-020-00160-6 505 downloads

Captação de recursos para pesquisas e o terceiro setor: o que os docentes sabem?
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Carvalho, Sabrina Brabo de Araújo

; Barros, Charles Alberto Villacorta de

; Limonge, Livia Gomes

; Carneiro, Andrey de Almeida

; Nylander, Bertho Vinicius Rocha

; Costa, Paula Lavigne de Sousa

Revista Brasileira de Educação Médica

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2021, Volume 45 N. 2 elocation e067

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo: Introdução: O crescimento socioeconômico de um país acontece por meio do desenvolvimento de ciência e tecnologia, e, por isso, a parceria com o terceiro setor é positiva ao auxiliar o financiamento de projetos científicos. Objetivos: Assim, o presente estudo objetiva avaliar as formas de captação de recursos mais utilizadas pelos docentes de Medicina para a execução de seus estudos científicos e verificar se há o reconhecimento do terceiro setor como opção para tal obtenção. Métodos: Trata-se de um estudo transversal analítico com abordagem quali-quantitativa, construído por meio do uso de um formulário individual aplicado aos docentes do curso médico de cinco instituições do ensino superior do Norte/Nordeste do Brasil. Os dados obtidos foram analisados por estatísticas descritiva e analítica. Resultados: Participaram 138 professores, de ambos os sexos, com idade média ± 43,2 anos. A pesquisa mais comumente desenvolvida pelos docentes foi a básica (56,1%); 68,8% utilizaram recursos próprios para o desenvolvimento de seus estudos; 18,8% obtiveram recursos de entidades de apoio à pesquisa; 75,4% conheciam alguma fundação de amparo à pesquisa, e as mais citadas foram a Fapespa (26,9%) e o CNPq (26,9%); 13,8% relataram conhecer sites e empresas multinacionais que fomentam projetos de pesquisas, mas somente 2,2% submeteram sua iniciativa às chamadas públicas em instituições internacionais para captação; quando perguntados sobre o terceiro setor, seus fundamentos e atores definidos pela legislação, o estudo apontou uma falta de conhecimento, com 100% de inadequação nas respostas sobre tais entidades; quanto à parceria entre o terceiro setor e o Estado, 83,3% sinalizaram desconhecimento;100% dos entrevistados desconhecem os critérios para uma entidade integrar tal setor, ao mesmo tempo que 76,8% afirmaram que a falta de orientação dos conceitos do ramo não é entrave para a captação de recursos às pesquisas. Conclusão: A maioria dos docentes utilizava recursos próprios para a realização de seus projetos, seguidos pelo uso de recursos públicos. Ademais, grande parte dos profissionais não reconheceu o terceiro setor como fonte patrocinadora, carecendo de informações que lhes possibilitassem desenvolver atividades de forma ampla e com as diversas oportunidades existentes, oferecidas por entidades desse setor.

Abstract: Introduction: The socio-economic growth of a country is reflected by the development of science and technology. Partnership with the third sector is therefore positive in terms of financial support for scientific projects. Objective: Accordingly, the present study aims to evaluate the most commonly used methods of fundraising by medical professors to conduct their scientific studies and whether there is recognition of the third sector as an option for such fundraising. Method: A cross-sectional analytical study with a qualitative and quantitative approach. The data were collected using an individual form, applied to medical course professors from five different universities in the north of Brazil, and analyzed using descriptive-analytical statistics. Results: The study included 138 professors, of both sexes, with an average age of ± 43.2 years. The type of research most commonly performed by professors was basic (56.1%); 68.8% used their own resources to develop their studies; 18.8% obtained funds from research support entities; 75.4% knew of a research support foundation, primarily FAPESPA (26.9%) and CNPQ (26.9%); 13.8% reported knowledge of websites and multinational companies that promote research projects, but only 2.2% submitted their initiative to public calls for funding from international institutions; when asked about the third sector, its fundamentals and actors defined by legislation, the study indicated a lack of knowledge, with 100% of inadequate answers about such entities; regarding partnership between the third sector and the State, 83.3% signaled ignorance; 100% of the interviewees were unaware of the criteria for an entity to be part of the sector, while 76.8% stated that lack of orientation about the concepts of the area is not an obstacle to raising funds for research. Conclusion: Most professors use their own funds to carry out their projects, followed by the use of public funds. Furthermore, most professionals did not recognize the third sector as a source of sponsorship, lacking information that would allow them to develop broad activities and enjoy the various opportunities offered by entities in this sector.

https://doi.org/10.1590/1981-5271v45.2-20200484 421 downloads

Brazilian Society of Rheumatology 2020 guidelines for psoriatic arthritis
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Carneiro, Sueli

; Palominos, Penelope Esther

; Anti, Sônia Maria Alvarenga

; Assad, Rodrigo Luppino

; Gonçalves, Rafaela Silva Guimarães

; Chiereghin, Adriano

; Lyrio, Andre Marun

; Ximenes, Antônio Carlos

; Saad, Carla Gonçalves

; Gonçalves, Célio Roberto

; Kohem, Charles Lubianca

; Marques, Cláudia Diniz Lopes

; Schainberg, Cláudia Goldenstein

; Meirelles, Eduardo de Souza

; Resende, Gustavo Gomes

; Pieruccetti, Lenise Brandao

; Keiserman, Mauro Waldemar

; Yazbek, Michel Alexandre

; Sampaio-Barros, Percival Degrava

; Lage, Ricardo da Cruz

; Bonfiglioli, Rubens

; Oliveira, Thauana Luíza

; Azevedo, Valderílio Feijó

; Bianchi, Washington Alves

; Bernardo, Wanderley Marques

; Simões, Ricardo dos Santos

; Pinheiro, Marcelo de Medeiros

; Campanholo, Cristiano Barbosa

Advances in Rheumatology

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2021, Volume 61 elocation 69

Abstract: En | Text: En | PDF: En

Abstract Psoriatic arthritis (PsA) is a chronic and systemic immune disease characterized by inflammation of peripheral and/ or axial joints and entheses in patients with psoriasis (PsO). Extra-articular and extracutaneous manifestations and numerous comorbidities can also be present. These recommendations replace the previous version published in May 2013. A systematic review of the literature retrieved 191 articles that were used to formulate 12 recommendations in response to 12 clinical questions, divided into 4 sections: diagnosis, non-pharmacological treatment, conventional drug therapy and biologic therapy. These guidelines provide evidence-based information on the clinical management for PsA patients. For each recommendation, the level of evidence (highest available), degree of strength (Oxford) and degree of expert agreement (interrater reliability) are reported.

https://doi.org/10.1186/s42358-021-00219-y

Metachromatic leukodystrophy: pediatric presentation and the challenges of early diagnosis
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Borges, Frederico Mendes

; Costa, Maria Júlia Gonzalez da

; Carneiro, Zumira Aparecida

; Lourenço, Charles Marques

Revista da Associação Médica Brasileira

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oct 2020, Volume 66 N. 10 Pages 1344 - 1350

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/1806-9282.66.10.1344 1036 downloads

[SciELO Preprints] - SARS-CoV-2 in Brazil and the psychosocial repercussions on male health: a socio-historical study
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Sousa, Anderson Reis de Santana, Thiago Da Silva Palma, Emanuel Missias Silva Sousa, Alvaro Francisco de Moreira, Wanderson Carneiro Rezende, Murilo Fernandes Merces, Magno Conceição das

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Publication date: 2020-06-02

Abstract: En Pt

Objective: To analyze the psychosomal repercussions of the pandemic of the new Coronavirus (SARS-CoV-2) on the health of men residing in Brazil. Method: Qualitative socio-historical study carried out with 200 men through an online survey between March and April across the country. The data were submitted to methodological analysis by the Collective Subject Discourse and anchored in the theoretical framework of epidemic disease proposed by Charles Rosemberg. Results: The repercussions evidenced were the changes and the emergence of new habits due to the pandemic; malaise in the family; damage to affective and sexual relationships; damage to marital relations; job insecurity and psychological distress. Conclusion: The pandemic context of the new Coronavirus brought repercussions of different dimensions that compromised the health of men residing in Brazil.

Objetivo: Analisar as repercussões psicossoais da pandemia do novo Coronavírus (SARS-cov-2) na saúde de homens residentes no Brasil. Método: Estudo sócio histórico, qualitativo realizado com 200 homens através de uma survey online entre março a abril em todo território nacional. Os dados foram submetidos à análise metodológica pelo Discurso do Sujeito Coletivo e ancorados no referencial teórico de doença epidêmica proposto por Charles Rosemberg. Resultados: As repercussões evidenciadas foram as mudanças e surgimento de novos hábitos em razão da pandemia; mal-estar na família; prejuízos nas relações afetivas e sexuais; prejuízos nas relações conjugais; insegurança laboral e sofrimento psquíquico Conclusão: O contexto pandemia do novo Coronavírus (SARS-cov-2) trouxe repercussões de dimensões distintas que comprometeram à saúde de homens residentes no Brasil.

https://doi.org/10.1590/SciELOPreprints.687

Sanfilippo Syndrome: The Tale of a Challenging Diagnosis
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Baldini, Giulianna

; Palmejiani, José Fernando

; Sant'Anna, João Pedro Bonevechio

; Carneiro, Zumira Aparecida

; Giugliani, Roberto

; Pereira, Catarina

; Cozma, Claudia

; O’Neill, Cara

; Lourenco, Charles M.

Journal of Inborn Errors of Metabolism and Screening

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2020, Volume 8 elocation e20200005

Abstract: En | Text: En | PDF: En

Abstract Sanfilippo syndrome or mucopolysaccharidosis III (MPS III), includes a group of four autosomal recessive lysosomal storage disorders caused by deficient activity of enzymes involved in the catabolism of heparan sulfate. The four types of MPS III are recognized in accordance with the deficient enzyme, resulting in the accumulation of heparan sulfate with particularly deleterious effects in the central nervous system. The incidence of MPS III remains to be established in Latin American countries. We describe the journey of a patient with MPS IIIB whom, even in the presence of speech delay and deterioration, behavioral problems and motor incoordination, showed unaltered urinary glycosaminoglycans (GAGs) levels. An investigation for MPS was undertaken and enzyme analysis indicated a deficiency of alpha-N-acetylglucosaminidase, leading to the diagnosis of MPS IIIB. With the correct diagnosis, the patient’s symptoms could be properly managed, and the parents received appropriate genetic counseling. The present case report reinforces the need of investigating MPS III in patients with language delay and/or regression, neurological impairment and behavioral alterations, even when urinary GAGs are within normal range. A definitive diagnosis ends the diagnostic journey and enables the medical team and family to provide a better care for the child.

https://doi.org/10.1590/2326-4594-jiems-2020-0005 1341 downloads

The Brazilian Society of Rheumatology guidelines for axial spondyloarthritis – 2019
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Resende, Gustavo Gomes

; Meirelles, Eduardo de Souza

; Marques, Cláudia Diniz Lopes

; Chiereghin, Adriano

; Lyrio, Andre Marun

; Ximenes, Antônio Carlos

; Saad, Carla Gonçalves

; Gonçalves, Célio Roberto

; Kohem, Charles Lubianca

; Schainberg, Cláudia Goldenstein

; Campanholo, Cristiano Barbosa

; Bueno Filho, Júlio Silvio de Sousa

; Pieruccetti, Lenise Brandao

; Keiserman, Mauro Waldemar

; Yazbek, Michel Alexandre

; Palominos, Penelope Esther

; Goncalves, Rafaela Silva Guimarães

; Lage, Ricardo da Cruz

; Assad, Rodrigo Luppino

; Bonfiglioli, Rubens

; Anti, Sônia Maria Alvarenga

; Carneiro, Sueli

; Oliveira, Thauana Luíza

; Azevedo, Valderílio Feijó

; Bianchi, Washington Alves

; Bernardo, Wanderley Marques

; Pinheiro, Marcelo de Medeiros

; Sampaio-Barros, Percival Degrava

Advances in Rheumatology

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2020, Volume 60 elocation 19

Abstract: En | Text: En | PDF: En

Abstract Spondyloarthritis is a group of chronic inflammatory systemic diseases characterized by axial and/or peripheral joints inflammation, as well as extra-articular manifestations. The classification axial spondyloarthritis is adopted when the spine and/or the sacroiliac joints are predominantly involved. This version of recommendations replaces the previous guidelines published in May 2013. A systematic literature review was performed, and two hundred thirty-seven studies were selected and used to formulate 29 recommendations answering 15 clinical questions, which were divided into four sections: diagnosis, non-pharmacological therapy, conventional drug therapy and biological therapy. For each recommendation the level of evidence supporting (highest available), the strength grade according to Oxford, and the degree of expert agreement (inter-rater reliability) is informed. These guidelines bring evidence-based information on clinical management of axial SpA patients, including, diagnosis, treatment, and prognosis.

https://doi.org/10.1186/s42358-020-0116-2 1116 downloads

10.

Suicidal ideation, anxiety, and depression in patients with multiple sclerosis
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Tauil, Carlos Bernardo

; Grippe, Talyta Cortez

; Dias, Ronaldo Maciel

; Dias-Carneiro, Rafael Paternò Castello

; Carneiro, Narel Moita

; Aguilar, Ana Carolina Rodrigues

; Silva, Flávia Martins da

; Bezerra, Felipe

; Almeida, Leonardo Kenzo de

; Massarente, Vitoria Lana

; Giovannelli, Elaine de Carvalho

; Tilbery, Charles Peter

; Brandão, Carlos Otávio

; Santos, Leonilda Maria B

; Santos-Neto, Leopoldo dos

Arquivos de Neuro-Psiquiatria

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may 2018, Volume 76 N. 5 Pages 296 - 301

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Transtornos psiquiátricos frequentemente ocorrem em pacientes com esclerose múltipla (EM). No entanto, os artigos sobre estas comorbidades são limitados. Pretendemos investigar as relações entre EM, ansiedade, depressão e ideação suicida. Métodos: Cento e trinta e dois pacientes com EM remitente-recorrente foram avaliados usando a Escala de Estado de Incapacidade Expandida, Inventário de Depressão de Beck-II (IDB-II), Escala de Beck para Ideação de Suicídio (BSI) e Escala de Ansiedade e Depressão. Resultados: Uma análise de regressão hierárquica foi realizada para avaliar as variáveis. A equação de regressão previu significativamente o escore BSI (R2 = 0,306; R2 ajustado = 0,273; F (9,125) = 9,18; p < 0,0005) e o escore no IDB-II foi a única variável que contribuiu significativamente para este modelo (p < 0,0005). Conclusões: Uma alta prevalência de depressão e ansiedade e uma maior taxa de ideação suicida foram identificadas em pacientes com EM em comparação com a população em geral. A presença de sintomas depressivos pareceu ter uma influência direta no risco de suicídio.

ABSTRACT Psychiatric disorders frequently occur in patients with multiple sclerosis (MS); however, limited reports are available on these comorbidities. We aimed to investigate the relationships among MS, anxiety, depression, and suicidal ideation. Methods: One hundred and thirty two patients with relapsing-remitting MS were evaluated using the Expanded Disability Status Scale, Beck Depression Inventory-II (BDI-II), Beck Scale for Suicide Ideation (BSI), and Hospital Anxiety and Depression Scale. Results: A hierarchical regression analysis was performed to evaluate the variables. The regression equation significantly predicted the BSI score (R2 = 0.306; adjusted R2 = 0.273; F (9, 125) = 9.18; p < 0.0005), and the BDI-II score was the only variable that contributed significantly to this model (p < 0.0005). Conclusions: A high prevalence of depression and anxiety, and a higher rate of suicidal ideation were identified in MS patients compared to the general population. The presence of depressive symptoms appeared to have a direct influence on the risk of suicide.

https://doi.org/10.1590/0004-282x20180036 4430 downloads

11.

Intake, digestibility, performance and carcass characteristics of ewes fed crambe replacing soybean meal in the diet
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Goes, Rafael Henrique de Tonissi e Buschinelli de

; Carneiro, Mayara Mitiko Yoshihara

; Osmari, Milene Puntel

; Souza, Kennyson Alves de

; Oliveira, Raquel Tenório de

; Souza, Charles Jhonnatan dos Santos

Acta Scientiarum. Animal Sciences

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2018, Volume 40 elocation e37171

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO. O uso de fontes proteicas alternativas para ruminantes pode alterar a produtividade e reduzir os custos na produção animal. O objetivo da pesquisa foi avaliar o desempenho, a digestibilidade aparente e as características quantitativas dos componentes de carcaça das ovelhas alimentadas com níveis crescentes (0, 50, 100 e 150 g kg-1 de matéria seca) de torta de crambe nas dietas. Foram distribuídas 24 ovelhas em um delineamento inteiramente casualizado. Todos os animais foram mantidos em instalação, com baias individuais equipadas com cocho, bebedouro e chão de concreto coberto com cascas de arroz. Os animais receberam silagem de milho como forragem e as dietas foram isoenergéticas com 700 g kg-1 de NDT. Os animais foram abatidos quando atingiram o escore de condição corporal de 3,5 pontos. A ingestão de matéria seca (948,53 g dia-1) e o ganho médio diário (0,15 kg dia-1) não foram influenciados pela inclusão de torta de crambe na dieta. A torta de crambe aumentou a digestibilidade do extrato etéreo e diminuiu a ingestão e digestibilidade da proteína bruta. Não houve efeito da torta de crambe nas características da carcaça e nos componentes não carcaça, no entanto houve redução no rendimento da carcaça fria. A substituição total da farinha de soja e a torta de crambe na dieta para as ovelhas não alteraram as características de desempenho, carcaça e não carcaça.

ABSTRACT. The use of alternative sources of protein for ruminant can alter productivity and reduce costs in animal production. The aim of this study was to evaluate the performance, apparent digestibility and quantitative characteristics of carcass components of ewes fed increasing levels (0, 50, 100 and 150 g kg-1 dry matter) of crambe crushed in the diets. Twenty-four culling ewes were distributed in a completely randomized design. All animals were kept in a shed, with individual stalls equipped with feeder, drinker and concrete floor covered with rice hulls. The animals received corn silage as roughage and diets were isoenergetic with 700 g kg-1 of TDN. Animals were slaughtered when reached a body condition score of 3.5 points. The dry matter intake (948.53 g day-1) and average daily gain (0.15 kg day-1) were not influenced by the inclusion of crambe crushed in the diet. The crambe crushed increased ether extract digestibility and decreased crude protein intake and digestibility. There was no effect of the levels of crambe crushed on carcass characteristics and non-carcass components but rather a reduction in the cold carcass yield. Total replacement of soybean meal with crambe crushed in the diet for ewes did not alter performance, carcass and non-carcass characteristics.

https://doi.org/10.4025/actascianimsci.v40i1.37171 933 downloads

12.

Physico-chemical characterization of centrifuged sludge from the Tamanduá water treatment plant (Foz do Iguaçu, PR)
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Ramirez, Kleber Gomes

; Possan, Edna

; Bittencourt, Paulo Rodrigo Stival

; Carneiro, Charles

; Colombo, Mauricio

Matéria (Rio de Janeiro)

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2018, Volume 23 N. 3 elocation e12187

Abstract: En | Text: En | PDF: En

ABSTRACT The water treatment process generates a residue called water treatment plant (WTP) sludge, which needs to be correctly characterized to ensure appropriate disposal or reuse. This study aimed to characterize the centrifuged sludge produced at the Tamanduá WTP, Iguaçu Falls City, Brazil, and considered opportunities for its reuse in the production of concrete for the civil construction industry. Wet sludge (sludge in its natural form) analysis included the determination of total solids, moisture content, density, pH, and inorganic parameters (As, Al, Ba, Cd, Pb, Cr, F, Hg, Ag, and Se) through thermogravimetric analysis, X-ray diffraction, and chemical analysis by X-ray fluorescence and loss ignition. For calcined WTP sludge, chemical and mineralogical composition and laser granulometry were evaluated. The results indicated that calcined sludge had the potential to be used in the production of cement materials; conversely wet sludge did not reach the appropriate safety standards due to the high quantity of organic matter.

https://doi.org/10.1590/s1517-707620180003.0521 1390 downloads

13.

Characterization of the first symptoms of multiple sclerosis in a Brazilian center: cross-sectional study
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Cavenaghi, Vitor Breseghello

; Dobrianskyj, Fernanda Martinho

; Olival, Guilherme Sciascia do

; Carneiro, Rafael Paternò Castello Dias

; Tilbery, Charles Peter

Sao Paulo Medical Journal

Journal Metrics
- Sobre o periódico
- SciELO Analytics

jun 2017, Volume 135 N. 3 Pages 222 - 225

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO CONTEXTO E OBJETIVO: A esclerose múltipla (EM) é uma doença crônica do sistema nervoso central (SNC) imunomediada e degenerativa, com critérios diagnósticos bem estabelecidos. O tratamento pode modificar o curso da doença. O objetivo deste estudo foi descrever os sintomas iniciais da esclerose múltipla em um centro médico brasileiro. TIPO DE ESTUDO E LOCAL: Estudo descritivo, conduzido em um centro médico de referência no tratamento de EM no Brasil. MÉTODOS: Foram incluídos no estudo dados de 299 pacientes com diagnóstico confirmado de EM. Seus prontuários foram avaliados e os dados foram analisados. RESULTADOS: O sintoma mais comum encontrado envolveu nervos cranianos (50,83%) e a manifestação unifocal foi apresentada pela maioria da população estudada (73,91%). O tempo médio entre o primeiro sintoma e o diagnóstico foi de 2,84 anos. O sintoma unifocal foi relacionado com maior tempo para o estabelecimento do diagnóstico, com uma média de 3,20 anos; enquanto para os sintomas multifocais, a média foi de 1,85 anos para o diagnóstico. O início unifocal foi relacionado a maior dificuldade de diagnóstico. CONCLUSÕES: EM é uma doença heterogênea e sua manifestação clínica inicial é muito variável.

ABSTRACT CONTEXT AND OBJECTIVE: Multiple sclerosis (MS) is a chronic, immune-mediated and degenerative central nervous system (CNS) disease with well-established diagnostic criteria. Treatment can modify the course of the disease. The objective of this study was to describe the initial symptoms of multiple sclerosis in a Brazilian medical center. DESIGN AND SETTING: Descriptive study, conducted in a Brazilian reference center for multiple sclerosis treatment. METHODS: Data on 299 patients with confirmed diagnoses of MS were included in the study. Their medical files were evaluated and the data were analyzed. RESULTS: The most common symptom involved the cranial nerves (50.83%) and unifocal manifestation was presented by the majority of this population (73.91%). The mean time between the first symptom and the diagnosis was 2.84 years. Unifocal symptoms correlated with longer time taken to establish the diagnosis, with an average of 3.20 years, while for multifocal symptoms the average time taken for the diagnosis was 1.85 years. Unifocal onset was related to greater diagnostic difficulty. CONCLUSIONS: MS is a heterogeneous disease and its initial clinical manifestation is very variable.

https://doi.org/10.1590/1516-3180.2016.0200270117 3197 downloads

14.

Qualidade de vida nas espondiloartrites: análise de uma grande coorte brasileira
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Ribeiro, Sandra L.E.

; Albuquerque, Elisa N.

; Bortoluzzo, Adriana B.

; Gonçalves, Célio R.

; Silva, José Antonio Braga da

; Ximenes, Antonio Carlos

; Bértolo, Manoel B.

; Keiserman, Mauro

; Menin, Rita

; Skare, Thelma L.

; Carneiro, Sueli

; Azevedo, Valderílio F.

; Vieira, Walber P.

; Bianchi, Washington A.

; Bonfiglioli, Rubens

; Campanholo, Cristiano

; Carvalho, Hellen M.S.

; Costa, Izaias P.

; Duarte, Angela L.B. Pinto

; Kohem, Charles L.

; Leite, Nocy H.

; Lima, Sonia A.L.

; Meirelles, Eduardo S.

; Pereira, Ivânio A.

; Pinheiro, Marcelo M.

; Polito, Elizandra

; Resende, Gustavo G.

; Rocha, Francisco Airton C.

; Santiago, Mittermayer B.

; Sauma, Maria de Fátima L.C.

; Valim, Valéria

; Sampaio-Barros, Percival D.

Revista Brasileira de Reumatologia

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feb 2016, Volume 56 N. 1 Pages 22 - 27

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Objetivo: Analisar as variáveis demográficas e clínicas associadas à diminuição da qualidade de vida em uma grande coorte brasileira de pacientes com espondiloartrite (EpA). Métodos: Foi aplicado um protocolo de pesquisa único a 1.465 pacientes brasileiros classificados como tendo EpA de acordo com os critérios do European Spondyloarthropaties Study Group (ESSG), atendidos em 29 centros de referência em reumatologia do Brasil. Foram registradas as variáveis clínicas e demográficas. A qualidade de vida foi analisada por meio do questionário Ankylosing Spondylitis Quality of Life (ASQoL). Resultados: A pontuação média do ASQoL foi de 7,74 (+ 5,39). Ao analisar doenças específicas no grupo de EpA, as pontuações do ASQoL não apresentaram diferença estatisticamente significativa. Os dados demográficos mostraram piores escores de ASQoL associados ao gênero feminino (p = 0,014) e etnia negra (p < 0,001). Quanto aos sintomas clínicos, a dor na região glútea (p = 0,032), a dor cervical (p < 0,001) e a dor no quadril (p = 0,001), estiveram estatisticamente associadas a piores escores no ASQoL. O uso contínuo de fármacos anti-inflamatórios não esteroides (p < 0,001) e agentes biológicos (p = 0,044) esteve associado a escores mais elevados de ASQoL, enquanto outros medicamentos não interferiram nos escores do ASQoL. Conclusão: Nesta grande série de pacientes com EpA, o sexo feminino e a etnia negra, bem como sintomas predominantemente axiais, estiveram associados a uma qualidade de vida reduzida.

Abstract Objective: To analyze quality of life and demographic and clinical variables associated to its impairment in a large Brazilian cohort of patients with spondyloarthritis (SpA). Methods: A common protocol of investigation was applied to 1465 Brazilian patients classified as SpA according to the European Spondyloarthropaties Study Group (ESSG) criteria, attended at 29 reference centers for Rheumatology in Brazil. Clinical and demographic variables were recorded. Quality of life was analyzed through the Ankylosing Spondylitis Quality of Life (ASQoL) questionnaire. Results: The mean ASQoL score was 7.74 (± 5.39). When analyzing the specific diseases in the SpA group, the ASQoL scores did not present statistical significance. Demographic data showed worse scores of ASQoL associated with female gender (p = 0.014) and African-Brazilian ethnicity (p < 0.001). Regarding clinical symptoms, buttock pain (p = 0.032), cervical pain (p < 0.001) and hip pain (p = 0.001), were statistically associated with worse scores of ASQoL. Continuous use of nonsteroidal anti-inflammatory drugs (p < 0.001) and biologic agents (p = 0.044) were associated with higher scores of ASQoL, while the other medications did not interfere with the ASQoL scores. Conclusion: In this large series of patients with SpA, female gender and African-Brazilian ethnicity, as well as predominant axial symptoms, were associated with impaired quality of life.

https://doi.org/10.1016/j.rbr.2015.03.003 3358 downloads

15.

Avaliação do desempenho do BASDAI (Bath Ankylosing Spondylitis Disease Activity Index) numa coorte brasileira de 1.492 pacientes com espondiloartrites: dados do Registro Brasileiro de Espondiloartrites (RBE)
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Costa, Izaias Pereira da

; Bortoluzzo, Adriana B.

; Gonçalves, Célio R.

; Silva, José Antonio Braga da

; Ximenes, Antonio Carlos

; Bértolo, Manoel B.

; Ribeiro, Sandra L.E.

; Keiserman, Mauro

; Menin, Rita

; Skare, Thelma L.

; Carneiro, Sueli

; Azevedo, Valderílio F.

; Vieira, Walber P.

; Albuquerque, Elisa N.

; Bianchi, Washington A.

; Bonfiglioli, Rubens

; Campanholo, Cristiano

; Carvalho, Hellen M.S.

; Duarte, Angela L.B. Pinto

; Kohem, Charles L.

; Leite, Nocy H.

; Lima, Sonia A.L.

; Meirelles, Eduardo S.

; Pereira, Ivânio A.

; Pinheiro, Marcelo M.

; Polito, Elizandra

; Resende, Gustavo G.

; Rocha, Francisco Airton C.

; Santiago, Mittermayer B.

; Sauma, Maria de Fátima L.C.

; Valim, Valéria

; Sampaio-Barros, Percival D.

Revista Brasileira de Reumatologia

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feb 2015, Volume 55 N. 1 Pages 48 - 54

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Objetivo Avaliar os resultados da aplicação do Índice de Atividade de Doença da Espondilite Anquilosante de Bath (BASDAI) numa série de pacientes brasileiros com EpA e estabelecer suas correlações com as variáveis específicas do grupo. Métodos Um protocolo comum de investigação foi prospectivamente aplicado em 1.492 pacientes brasileiros classificados como EpA pelos critérios do Grupo Europeu de Estudo das Espondiloartropatias (ESSG), acompanhados em 29 centros de referência em reumatologia no Brasil. Variáveis clínicas, demográficas e índices de doença foram colhidos. Os valores totais do BASDAI foram comparados com a presença das diferentes variáveis. Resultados O valor médio do BASDAI foi de 4,20 ± 2,38. Os escores médios do BASDAI foram mais elevados nos pacientes com forma clínica combinada, comparado às formas axiais e periféricas isoladas, nos pacientes do sexo feminino e nos sedentários. Com relação ao componente axial, valores mais altos do BASDAI estiveram significativamente associados à lombalgia inflamatória, à dor alternante em nádegas, à dor cervical e ao acometimento de coxofemorais. Houve associação estatística entre os valores do BASDAI e o comprometimento periférico, relacionado ao número de articulações inflamadas, tanto dos membros inferiores quanto dos membros superiores, e às entesites. A positividade do HLA-B27 e a presença de manifestações extra-articulares não estiveram correlacionadas com os valores médios do BASDAI. Valores mais baixos do BASDAI estiveram associados ao uso de agentes biológicos (p < 0,001). Conclusão Nesta série heterogênea de pacientes brasileiros com EpA, o BASDAI conseguiu demonstrar “atividade de doença” tanto nos pacientes com acometimento axial quanto naqueles com envolvimento periférico.

Objective To analyze the results of the application of the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) in a large series of Brazilian patients with the diagnosis of SpA and establish its correlations with specific variables into the group. Methods A common protocol of investigation was prospectively applied to 1492 Brazilian patients classified as SpA according to the European Spondyoarthropathies Study Group (ESSG), attended at 29 referral centers of Rheumatology in Brazil. Clinical and demographic variables, and disease indices (BASDAI, Basfi, Basri, Mases, ASQol) were applied. The total values of BASDAI were compared to the presence of the different variables. Results The mean score of BASDAI was 4.20 ± 2.38. The mean scores of BASDAI were higher in patients with the combined (axial + peripheral + entheseal) (4.54 ± 2.38) clinical presentation, compared to the pure axial (3.78 ± 2.27) or pure peripheral (4.00 ± 2.38) clinical presentations (P < 0.001). BASDAI also presented higher scores associated with the female gender (P < 0.001) and patients who did not practice exercises (P < 0.001). Regarding the axial component, higher values of BASDAI were significantly associated with inflammatory low back pain (P < 0.049), alternating buttock pain (P < 0.001), cervical pain (P < 0.001) and hip involvement (P < 0.001). There was also statistical association between BASDAI scores and the peripheral involvement, related to the lower (P = 0.004) and upper limbs (P = 0.025). The presence of enthesitis was also associated to higher scores of BASDAI (P = 0.040). Positive HLA-B27 and the presence of cutaneous psoriasis, inflammatory bowel disease, uveitis and urethritis were not correlated with the mean scores of BASDAI. Lower scores of BASDAI were associated with the use of biologic agents (P < 0.001). Conclusion In this heterogeneous Brazilian series of SpA patients, BASDAI was able to demonstrate “disease activity” in patients with axial as well as peripheral disease.

https://doi.org/10.1016/j.rbr.2014.05.005 12259 downloads

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