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Abstract Objective: To assess the predictive value of selected growth phenotypes for neonatal morbidity and mortality in preterm infants < 30 weeks and to compare them with INTERGROWTH-21st (IG21). Methods: Retrospective analysis of data from the Brazilian Neonatal Research Network (BNRN) database for very low birth weight (VLBW) at 20 public tertiary-care university hospitals. Outcome: the composite neonatal morbidity and mortality (CNMM) consisted of in-hospital death, oxygen use at 36 weeks, intraventricular hemorrhage grade 3 or 4, and Bell stage 2 or 3 necrotizing enterocolitis. Selected growth phenotypes: small-for-gestational-age (SGA) defined as being < 3rd (SGA3) or 10th (SGA10) percentiles of BW, and large-for-gestational-age (LGA) as being > 97th percentile of BW. Stunting as being < 3rd percentile of the length and wasting as being < 3rd percentile of BMI. Single and multiple log-binomial regression models were fitted to estimate the relative risks of CNMM, comparing them to IG21. Results: 4,072 infants were included. The adjusted relative risks of CNMM associated with selected growth phenotypes were (BNRN/IG21): 1.45 (0.92–2.31)/1.60 (1.27–2.02) for SGA; 0.90 (0.55–1.47)/1.05 (0.55–1.99) for LGA; 1.65 (1.08–2.51)/1.58 (1.28–1.96) for stunting; and 1.48 (1.02–2.17) for wasting. Agreement between the two references was variable. The growth phenotypes had good specificity (>95%) and positive predictive value (70-90%), with poor sensitivity and low negative predictive value. Conclusion: The BNRN phenotypes at birth differed markedly from the IG21 standard and showed poor accuracy in predicting adverse neonatal outcomes.

https://doi.org/10.1016/j.jped.2022.07.007

Amplifications of AURKA and AURKB in a Burkitt lymphoma immunodeficiency-associated type: a case report
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Oliveira, Fábio Morato de

; Souza, Vinícius Gonçalves de

; Carvalho, Aparecida de Lourdes

; Lizarte Neto, Fermino Sanches

; Miranda, Carla Silva Siqueira

einstein (São Paulo)

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2023, Volume 21 elocation eRC0378

Abstract: En | Text: En | PDF: En

ABSTRACT In equatorial Brazil, the association of Burkitt lymphoma and Epstein–Barr virus manifests at high rates. Here, we report, for the first time, amplifications of aurora kinase genes (AURKA/B) in a patient with a history of periodontal abscess and the presence of a remaining nodule, diagnosed with Burkitt lymphoma and Epstein–Barr virus, and /HIV positive. The patient was a 38-year-old man who presented with a 2-week-old severe jaw pain and a 3-day-old severe bilateral headache. He had a history of human papilloma virus. Interphase FISH analysis showed AURKA and AURKB amplification. The patient’s condition worsened, progressing to death a month after the initial care. Changes in the MYCC and AURKA pathways are directly associated with genomic instability. Thus, MYCC rearrangements and higher expression of AURKA/B may be associated with therapy resistance, highlighting the importance of AURKA/B evaluation in Burkitt lymphoma.

https://doi.org/10.31744/einstein_journal/2023rc0378

Accurate diagnosis of breast lesions Number 4 – April 2023
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Andrade, Alexandre Vicente de

; Lucena, Clécio Ênio Murta de

; Santos, Danielle Chambô dos

; Pessoa, Eduardo Carvalho

; Mansani, Fabio Postiglione

; Andrade, Felipe Eduardo Martins de

; Tosello, Giuliano Tavares

; Pasqualette, Henrique Alberto Portella

; Couto, Henrique Lima

; Francisco, Jose Luis Esteves

; Costa, Rodrigo Pepe

; Teixeira, Sandra Regina Campos

; Moraes, Thaís Paiva

; Silva Filho, Agnaldo Lopes da

Revista Brasileira de Ginecologia e Obstetrícia

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2023, Volume 45 N. 4 Pages 215 - 219

Abstract: En | Text: En | PDF: En

https://doi.org/10.1055/s-0043-1769468

Surgical treatment of rectal cancer: prospective cohort study about good oncologic results and low rates of abdominoperineal excision
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FAIER, THAIS ANDRESSA SILVA

; QUEIROZ, FABIO LOPES

; LACERDA-FILHO, ANTÔNIO

; PAIVA, RODRIGO ALMEIDA

; FRANÇA NETO, PAULO ROCHA

; CORTES, MARCELO GIUSTI WERNECK

; CARVALHO, ALEXANDRE RIBAS DE

; PEREIRA, BARBARA MARIA TAVARES

Revista do Colégio Brasileiro de Cirurgiões

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2023, Volume 50 elocation e20233435

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT Objectives: the purpose of this study was to evaluate the outcome of rectal cancer surgery, in a unit adopting the principles of total mesorectal excision (TME) with a high restorative procedure rate and with a low rate of abdominoperineal excision (APE). Methods: we enrolles patients with extraperitoneal rectal cancer undergoing TME or TME+APE. Patients with mid rectal tumors underwent TME, and patients with tumors of the lower rectum and no criteria for APE underwent TME and intersphincteric resection. Those in which the intersphincteric space was invaded and in those with a free distal margin less than 1cm or a tumor free radial margin were unattainable underwent APE or extralevator abdominoperineal excision (ELAPE). We assessed local recurrence rates, overall survival and involvement of the radial margin. Results: sixty (89.6%) patients underwent TME and seven (10.4%) TME + APE, of which five underwent ELAPE. The local recurrence, in pacientes undergoing TME+LAR, was 3.3% and in patients undergoing APE, 14.3%. The local recurrence rate (p=0.286) or the distant recurrence rate (p=1.000) was similar between groups. There was no involvement of radial margins. Survival after 120 months was similar (p=0.239). Conclusion: rectal malignancies, including those located in the low rectum, may be surgically treated with a low rate of APE without compromising oncological principles and with a low local recurrence rates.

RESUMO Objetivos: o objetivo deste estudo foi avaliar os resultados da cirurgia do câncer de reto, em uma unidade que adota os princípios da excisão total do mesorreto (ETM) com baixa taxa de amputação abdominoperineal (AAP). Métodos: os pacientes com câncer retal extraperitoneal foram submetidos a ETM ou ETM com amputação abdominoperianeal. Pacientes com tumores de reto médio foram submetidos a EMT e pacientes com tumores de reto inferior e sem critérios para AAP foram submetidos a EMT e ressecção interesfincteriana. Aqueles em que o espaço interesfincteriano foi invadido e naqueles com margem distal livre menor que 1cm ou margem radial livre de tumor foram inatingíveis foram submetidos a AAP ou excisão abdominoperineal extraelevadora (ELAPE). Avaliamos as taxas de recorrência local, sobrevida global e envolvimento da margem radial. Resultados: sessenta (89,6%) pacientes realizaram ETM e sete (10,4%) ETM + AAP, dos quais cinco realizaram ELAPE. A recidiva local, em pacientes submetidos a ETM com ressecção anterior baixa, foi de 3,3% e em pacientes submetidos a AAP, 14,3%. A taxa de recorrência local (p=0,286) ou a taxa de recorrência à distância (p=1,000) foi semelhante entre os grupos. Não houve envolvimento das margens radiais. A sobrevida após 120 meses foi semelhante (p=0,239). Conclusão: as neoplasias malignas retais, incluindo aquelas localizadas no reto baixo, podem ser tratadas cirurgicamente com baixo índice de AAP, sem comprometer os princípios oncológicos e com baixo índice de recorrência local.

https://doi.org/10.1590/0100-6991e-20233435-en

Clinicopathologic analysis of oral dermoid and epidermoid cysts: a Brazilian multicenter study
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CUNHA, John Lennon Silva

; ANDRADE, Allany de Oliveira

; CAVALCANTE, Israel Leal

; BARROS, Caio César da Silva

; SOUSA NETO, Sebastião Silvério de

; BARROS, Joyce Magalhães de

; LEITE, Larissa Sandy da Silva

; FÉLIX, Fernanda Aragão

; TURATTI, Eveline

; CARVALHO, Francisco Samuel Rodrigues

; SOUSA, Sílvia Ferreira de

; MENDONÇA, Elismauro Francisco de

; ANBINDER, Ana Lia

; PIRES, Fábio Ramoa

; ALVES, Pollianna Muniz

; NONAKA, Cassiano Francisco Weege

; ANDRADE, Bruno Augusto Benevenuto de

Brazilian Oral Research

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2023, Volume 37 elocation e107

Abstract: En | Text: En | PDF: En

Abstract Dermoid cysts (DCs) and epidermoid cysts (ECs) are uncommon developmental cysts affecting the oral cavity. This study aims to evaluate patients with oral DCs and ECs and their demographic and clinicopathologic features. A retrospective descriptive cross-sectional study was performed. A total of 105,077 biopsy records of oral and maxillofacial lesions from seven Brazilian oral pathology centers were analyzed. All cases diagnosed as oral DCs and ECs were reviewed, and clinical, demographic, and histopathological data were collected. The series comprised 32 DCs (31.4%) and 70 ECs (68.6%). Most of the DCs occurred on the floor of the mouth (n = 14; 45.2%) of women (n = 17; 53.1%) with a mean age of 34.6 ± 21.6 years. All DCs were lined partially or entirely by stratified squamous epithelium (100%). Chronic inflammatory cells, melanin pigmentation, multinucleated giant cell reaction, and cholesterol clefts were observed in the fibrous capsule . Most of the ECs affected the labial mucosa (n = 20; 31.7%) of men (n = 39; 56.5%) with a mean age of 48.0±19.8 years. Microscopically, most ECs (n = 68; 97.1%) were lined entirely by stratified squamous epithelium. Two cysts (2.9%) showed areas of respiratory metaplasia. Chronic inflammatory cells, melanin pigmentation, multinucleated giant cell reaction, and cholesterol clefts were also observed in the fibrous capsule. Conservative surgical excision was the treatment of choice in all cases. Oral DCs and ECs are uncommon and often clinically misdiagnosed lesions. Clinicians should consider DCs and ECs in the differential diagnosis of soft tissue lesions in the oral cavity, mainly located on the floor of the mouth and labial mucosa.

https://doi.org/10.1590/1807-3107bor-2023.vol37.0107

Challenges of breast cancer screening: Number 9 – September 2023
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Andrade, Alexandre Vicente de

; Lucena, Clécio Ênio Murta de

; Santos, Danielle Chambô dos

; Pessoa, Eduardo Carvalho

; Mansani, Fabio Postiglione

; Andrade, Felipe Eduardo Martins de

; Tosello, Giuliano Tavares

; Pasqualette, Henrique Alberto Portella

; Couto, Henrique Lima

; Francisco, Jose Luis Esteves

; Costa, Rodrigo Pepe

; Teixeira, Sandra Regina Campos

; Moraes, Thaís Paiva

; Silva Filho, Agnaldo Lopes da

Revista Brasileira de Ginecologia e Obstetrícia

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2023, Volume 45 N. 9 Pages 551 - 554

Abstract: En | Text: En | PDF: En

https://doi.org/10.1055/s-0043-1775931

Pyroligneous extracts with therapeutic action: A technological prospect action
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Moura, Fábio Souza

; Santos, Éder da Silva Rocha

; Varjão, Márcio Thomaz dos Santos

; Santos, Hilda Caroline do Nascimento

; Silva, Andressa Letícia Lopes da

; Soletti, João Inácio

; Carvalho, Sandra Helena Vieira de

; Duarte, Alysson Wagner Fernandes

; Moreira, Magna Suzana Alexandre

; Queiroz, Aline Cavalcanti de

Brazilian Journal of Pharmaceutical Sciences

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2023, Volume 59 elocation e23351

Abstract: En | Text: En | PDF: En

Abstract The Pyroligneous extract is a product from the combustion of plant biomass with applications in the fields of health, industrial chemistry, and agriculture. The discovery of new molecules with therapeutic potential and of natural origin continues to be one of the great challenges for research centres around the world. The following work aims to analyze, through a technological prospection, the use of pyroligneous extracts for therapeutic purposes. To carry out the study, searches were carried out in documents deposited in Brazil, Europe, and the United States and searched on platforms specialized in patents. The number of inventions using pyroligneous extract with therapeutic applications is still quite small, however, innovations have been observed for the treatment of diseases of great clinical relevance such as cancer and hypertension. The systematic mapping of innovations is of great importance for the development of new technologies. health chemistry agriculture world analyze prospection purposes study Brazil Europe patents small however hypertension technologies

https://doi.org/10.1590/s2175-97902023e23351

Feasibility of a snowball sampling survey to study active surveillance for thyroid microcarcinoma treatment among endocrinologists and surgeons of Brazil
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Silva, Isabela Matos da

; Nogueira, Taísa Quécia da Silva

; Couto, Deborah Nogueira

; Lima, Paula Cristina Tanajura Meira

; Bonfim, Natália Sampaio Carvalho

; Sousa, Izadora Gomes Veiga de

; Telles, Ana Clara Tosta

; Hecht, Fábio

; Alkmim, Nina Ramalho

; Penna, Gustavo Cancela e

; Ferraz, Carolina

; Tomimori, Eduardo

; Ramos, Helton Estrela

Brazilian Journal of Otorhinolaryngology

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dec 2022, Volume 88 Pages S163 - S169

Abstract: En | Text: En | PDF: En

Abstract Objectives: This study aims to investigate if a sampling method using virtual networks is feasible to survey AS adoption among this “hard-to-reach” population of Brazilian doctors. Methods: An online piloted 11-point structured survey questionnaire (designed using Googleforms®) probed the actual treatment patterns for adult patients with PTMCs, including treatment decision-making nonoperative options, was undertaken between 10 November and 30 November 2020. Participants were reached by the mobile phone Application (APP) and a snowball sampling strategy was used to recruit a total of 4783 members (maximum number of potential reach), which is the total of doctors of the all 21 social media WhatsApp® groups. Results: From a total of 4783 members (maximum number of potential reach), there were 657 (13.7%) doctors (actual reach) who clicked the web link of the questionnaire, out of whom 512 (10.7%) fully completed the online survey. Among the survey respondents, 361 were endocrinologists (70.5%) and 151 were surgeons (29.5%). Overall, for low-risk PTMCs in an elderly patient, 118 responders (23%) recommend AS, while 390 (76%) recommend immediate surgery as the management, including lobectomy (18.5%) and Total Thyroidectomy (58.2%). The present responders tended to recommend surgery for PTMCs that were located adjacent to the dorsal surface of the thyroid, were multiple, or raised the size during the follow-up. Conclusion: Using snowball sampling strategy as an innovative route to conduct surveys was feasible and applicable but the rate of response was still very low. Our data also suggests the need to investigate if AS is embraced by Brazilian doctors.

https://doi.org/10.1016/j.bjorl.2022.01.005

10.

Oral mucoceles: A Brazillian Multicenter Study of 1,901 Cases
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Miranda, Georgea Gabriela Barreto

; Chaves-Junior, Samuel de Carvalho

; Lopes, Matheus Paschoaletto

; Rocha, Talytha Barbosa da

; Colares, Débora Frota

; Ito, Fábio Augusto

; Cavalcante, Israel Leal

; Cavalcante, Roberta Barroso

; Andrade, Bruno Augusto Benevenuto de

; Nonaka, Cassiano Francisco Weege

; Alves, Pollianna Muniz

; Albuquerque-Júnior, Ricardo Luiz Cavalcanti de

; Cunha, John Lennon Silva

Brazilian Dental Journal

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oct 2022, Volume 33 N. 5 Pages 81 - 90

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo A mucocele oral (MO) é a lesão mais comum das glândulas salivares menores. O presente estudo teve como objetivo relatar as características clínicas e demográficas de uma grande série de MOs e identificar possíveis variáveis preditivas associadas à taxa de recorrência dessas lesões. Foi realizado um estudo transversal descritivo retrospectivo. Foram analisados 43.754 registros de biópsias de quatro serviços de patologia no Brasil. Todos os casos diagnosticados como MOs foram revisados e dados clínicos e demográficos foram coletados. Participaram do estudo 1.002 mulheres (56,2%) e 782 homens (43,8%), com média de idade de 19,8 ± 16,4 anos (variação: 01-87 anos) e proporção de mulheres para homens de 1,3:1. O lábio inferior (n=1.160; 67,4%) e assoalho da boca (n=172; 10,0%), foram os locais mais acometidos, apresentando-se clinicamente como nódulos (n=978; 79,4%) de superfície lisa (n =428; 77,5%) e coloração normal (n=768, 46,7%). A biópsia excisional foi o tratamento na maioria dos casos (n=1.392; 78,0%). As MOs recorrentes representaram 6,2% de todos os casos diagnosticados (n = 117). As recorrências recorreram mais comumente em pacientes mais jovens (idade < 20 anos) (p < 0,0001), em lesões maiores que 2 cm de diâmetro (p < 0,0001) e naquelas localizadas na superfície ventral da língua (p = 0,0351). Além disso, as taxas de recorrência foram significativamente maiores nos casos tratados com cirurgia a laser do que aqueles com cirurgia convencional utilizando bisturi (p = 0,0005). Pacientes com mucoceles devem ser informados sobre uma possível recorrência, principalmente quando encontrados no lábio ou assoalho bucal de pacientes jovens.

Abstract Oral mucocele (OM) is the most common lesion of minor salivary glands. The present study aimed to report the clinical and demographic features of a large series of OMs and identify possible predictive variables associated with the recurrence rate of these lesions. A retrospective descriptive cross-sectional study was performed. A total of 43,754 biopsy records from four pathology services in Brazil were analyzed. All cases of OMs were reviewed, and clinical and demographic data were collected. The study comprised 1,002 females (56.2%) and 782 males (43.8%), with a mean age of 19.8±16.4 years (range: 01-87 years) and a 1.3:1 female-to-male ratio. The lower lip (n=1,160; 67.4%), and floor of the mouth (n=172; 10.0%), were the most common affected sites, presenting clinically as nodules (n=978; 79.4%) of smooth surface (n=428; 77.5%) and normal color (n=768, 46.7%). Excisional biopsy was the treatment in most cases (n=1,392; 78.0%). Recurrent OMs represented 6.2% of all diagnosed cases (n=117). OMs recurred more commonly in younger patients (aged<20 years) (p<0.0001), in lesions larger than 2 cm in diameter (p<0.0001), and in those located in the ventral tongue (p=0.0351). Also, recurrence rates were higher significantly in cases treated with laser surgery than in those with conventional surgery (p=0.0005). Patients with OMs should be carefully informed of its possible recurrence, especially when found on the ventral tongue of young patients.

https://doi.org/10.1590/0103-6440202204965

11.

Detoxified castor-bean meal replaces soybean meal in the diet of pasture-finished steers
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Ribeiro Lima, Antônio Carlos

; Rodrigues Silva, Robério

; Andrade Teixeira, Fábio

; Ferreira da Silva, Fabiano

; Mendes Machado, Silvia Layse

; de Melo Lisboa, Mateus

; Silva Pereira, Maria Magna

; Macedo Carvalho, Venício

; da Conceição Santos, Marceliana

; Morais de Lima Júnior, Dorgival

Chilean journal of agricultural research

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sep 2022, Volume 82 N. 3 Pages 371 - 379

Abstract: En | Text: En | PDF: En

ABSTRACT The use of agroindustrial byproducts in cattle diets, such as castor-bean (Ricinus communis L.) meal, is a more sustainable practice because it does not compete with human food and reduces the volume of organic waste deposited in the environment. The aim of this study was to examine the effect of replacing soybean (Glycine max (L.) Merr.) meal with castor-bean meal on the intake, digestibility, feeding behavior and performance of crossbred steers supplemented while on Urochloa brizantha (Hochst. ex A. Rich.) R.D. Webster ‘Marandu’ pasture. The experiment was laid out in a randomized complete design with 40 animals, which started the experiment weighing 227.1 kg, at 10 mo of age, and were divided into four treatment groups. Castor-bean meal was added to replace soybean meal at the levels of 0, 90, 180, and 280 g kg-1 in the supplement, which was supplied at the rate of 0.4% of body weight. Total DM, pasture DM and neutral detergent fiber intakes did not change (P > 0.05) with the castor-bean levels added to the supplement. Ether extract intake and digestibility decreased linearly (P < 0.05). The animals showed no differences (P > 0.05) in production performance (average daily gain), which averaged 0.65 kg d-1. Grazing, idle, and rumination times were not influenced (P > 0.05) by the treatments. Castor-bean meal can be included up to 280 g kg-1 in the total diet without changing the performance of crossbred steers finished on tropical pasture.

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12.

GENETIC AND MORPHOLOGICAL DESCRIPTORS TO ACCESS BRAZILIAN OKRA GENOTYPES DIVERSITY
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CARVALHO, FÁBIO JANONI

; MENDONÇA, THIAGO FELLIPE NUNES DE

; SIQUIEROLI, ANA CAROLINA SILVA

; MACIEL, GABRIEL MASCARENHAS

; CLEMENTE, ANDRESSA ALVES

Revista Caatinga

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jun 2022, Volume 35 N. 2 Pages 254 - 264

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Informações da variação de importantes características morfológicas e fisiológicas do quiabo são limitadas. A análise molecular é uma ferramenta adicional importante nos estudos de caracterização de germoplasma. O estudo teve como objetivo avaliar o desempenho do crescimento e da produção de 20 acessos pré-comerciais de quiabo para identificar a associação de marcadores moleculares com características morfológicas. Dezenove caracteres morfológicos foram medidos com cinco descritores qualitativos e 14 quantitativos. Para a análise dos padrões genéticos, foram utilizados marcadores RAPD com nove primers e 24 bandas utilizáveis. A dissimilaridade genética foi avaliada com base em matrizes morfológicas e genéticas. Além disso, a representação gráfica das distâncias genéticas foi realizada pelo método UPGMA e otimização de Tocher. A caracterização morfológica dos acessos detectou polimorfismo para todas as características avaliadas. Os marcadores RAPD foram eficientes na detecção da variabilidade genética entre os acessos de quiabo. Para os primers usados no experimento, apenas OPE10 não amplificou a fita de DNA. Os outros oito primers produziram um total de 35 bandas, sendo 25 polimórficas e dez monomórficas. Os caracteres morfológicos e marcadores moleculares identificaram ampla variabilidade genética entre os 20 acessos de quiabo, indicando a possibilidade de cruzamentos bem-sucedidos em programas de melhoramento e o isolando genótipos interessantes. As análises morfológica e molecular foram complementares e auxiliaram na seleção dos genótipos. A análise molecular indicou alguns acessos divergentes que não foram encontrados na análise morfológica, o que poderia destacar alguns materiais que apresentam uma característica desejável, sendo interessantes para detectar características de dificil mensuração em campo.

ABSTRACT Information of the variation for important morphological and physiological traits of okra is still limited. Molecular analysis is an important additional tool in germplasm characterization studies. The study aimed to evaluate the performance of the growth and yield of 20 pre-commercial okra accessions to identify molecular markers’ association with morphological traits. Nineteen morphological traits were measured with five qualitative and 14 quantitative descriptors. For analysis of genetic patterns Random Amplified Polymorphic DNA (RAPD) markers were used with nine primers and 24 usable bands. The genetic dissimilarity was evaluated based in morphological and genetic matrices. Also, graphical representation of genetic distances was obtained by UPGMA and Tocher’s optimization method. The morphological characterization of the accessions detected polymorphism for all evaluated traits. RAPD markers were efficient in detecting genetic variability among okra accessions. For the primers used in the experiment, only OPE10 did not amplify the DNA strand. The other eight primers produced a total of 35 bands, in which 25 were polymorphic and ten were monomorphic. The morphological traits and molecular markers identified wide genetic variability among the 20 okra accessions, indicating successful crosses in breeding programs and isolating some interesting materials. Morphological and molecular cluster analyses were complementary and helped in the genotype selection. Molecular analysis indicated some divergent accessions that were not found in morphological analysis, which could highlight some materials that have a desirable trait, that is difficult and highly costly to access in field experiments.

https://doi.org/10.1590/1983-21252022v35n202rc

13.

Evaluating the psychometric properties of the eHealth Literacy Scale in Brazilian adults
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Mialhe, Fábio Luiz

; Moraes, Katarinne Lima

; Sampaio, Helena Alves de Carvalho

; Brasil, Virgínia Visconde

; Vila, Vanessa da Silva Carvalho

; Soares, Gustavo Hermes

; Rebustini, Flávio

Revista Brasileira de Enfermagem

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2022, Volume 75 N. 1 elocation e20201320

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivo: Traduzir e adaptar a eHealth Literacy Scale para a realidade cultural do Brasil e avaliar suas propriedades psicométricas da versão em português brasileiro. Métodos: O instrumento foi traduzido e adaptado ao português brasileiro e, em seguida, aplicado em uma amostra de 502 indivíduos entre 18 e 80 anos residentes em áreas circunvizinhas a seis Unidades de Saúde da Família de um município do interior do estado de São Paulo, Brasil. Os dados foram avaliados mediante análises fatorial exploratória e confirmatória, Teoria de Resposta ao Item e confiabilidade do instrumento (alfa de Cronbach e ômega de McDonald). Resultados: O instrumento eHealth Literacy Scale - versão brasileira (eHEALS-Br) apresentou excelente consistência interna (α = 0,95 e ω = 0,95), apenas uma dimensão e variância explicada de 81,79%. Conclusões: A versão brasileira do instrumento mostrou excelentes propriedades psicométricas para aferição dos níveis de letramento digital em saúde em adultos do nosso país.

ABSTRACT Objective: To translate and adapt the eHealth Literacy Scale for the cultural reality of Brazil and to evaluate the psychometric properties of its Brazilian Portuguese version. Methods: The instrument was translated and adapted to Brazilian Portuguese and applied to a sample of 502 individuals from 18 to 80 years old who lived in the surrounding areas of six Family Health Units of a city in the countryside of the state of São Paulo, Brazil. The data was evaluated using exploratory and confirmatory factor analysis, item response theory, and instrument reliability measures (Cronbach’s alpha and McDonald’s omega). Results: The eHealth Literacy Scale - Brazilian version (eHEALS-Br) presented an excellent internal consistency (α = 0.95 e ω = 0.95), with only one dimension and an explained variation of 81.79%. Conclusions: The Brazilian version of the instrument showed excellent psychometric properties to measure the levels of digital health literacy in adults from the country.

RESUMEN Objetivo: Traducir y adaptar la eHealth Literacy Scale a realidad cultural Brasileña y evaluar sus propiedades psicométricas de la versión en portugués brasileño. Métodos: El instrumento fue traducido y adaptado al portugués brasileño y, en seguida, aplicado en una muestra de 502 individuos entre 18 y 80 años residentes en áreas cercas a seis Unidades de Salud de la Familia de un municipio del interior del estado de São Paulo, Brasil. Los datos fueron evaluados mediante análisis factorial exploratoria y confirmatoria, Teoría de Respuesta al Ítem y confiabilidad del instrumento (alfa de Cronbach y omega de McDonald). Resultados: El instrumento eHealth Literacy Scale - versión brasileña (eHEALS-Br) presentó excelente consistencia interna (α = 0,95 y ω = 0,95), apenas una dimensión y variancia explicada de 81,79%. Conclusiones: La versión brasileña del instrumento mostró excelentes propiedades psicométricas para contraste de los niveles de alfabetización digital en salud en adultos del nuestro país.

https://doi.org/10.1590/0034-7167-2020-1320 325 downloads

14.

New possibilities for chromoblastomycosis and phaeohyphomycosis treatment: identification of two compounds from the MMV Pathogen Box® that present synergism with itraconazole
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Coelho, Rowena Alves

; Alves, Gabriela Machado

; Figueiredo-Carvalho, Maria Helena Galdino

; Almeida-Silva, Fernando

; de Souza, Gabriela Rodrigues

; Lourenço, Maria Cristina da Silva

; Brito-Santos, Fábio

; Amaral, Ana Claudia Fernandes

; Almeida-Paes, Rodrigo

Memórias do Instituto Oswaldo Cruz

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2022, Volume 117 elocation e220089

Abstract: En | Text: En | PDF: En

BACKGROUND Black fungi of the Herpotrichiellaceae family are agents of chromoblastomycosis and phaeohyphomycosis. There are few therapeutic options for these infections and it is common to associate antifungal drugs in their treatment. OBJECTIVES To investigate the Medicines for Malaria Venture (MMV) Pathogen Box® for possible compounds presenting synergism with antifungal drugs used to treat black fungal infections. METHODS An initial screening of the Pathogen Box® compounds was performed in combination with itraconazole or terbinafine at sub-inhibitory concentrations against Fonsecaea pedrosoi. Hits were further tested against eight Herpotrichiellaceae using the checkerboard method. FINDINGS No synergism was observed with terbinafine. MMV687273 (SQ109) and MMV688415 showed synergism with itraconazole against F. pedrosoi. Synergism of these compounds was confirmed with some black fungi by the checkerboard method. SQ109 and itraconazole presented synergism for Exophiala dermatitidis, F. pedrosoi, F. monophora and F. nubica, with fungicidal activity for F. pedrosoi and F. monophora. MMV688415 presented synergism with itraconazole only for F. pedrosoi, with fungicidal activity. The synergic compounds had high selectivity index values when combined with itraconazole. MAIN CONCLUSIONS These compounds in combination, particularly SQ109, are promising candidates to treat Fonsecaea spp. and E. dermatitidis infections, which account for most cases of chromoblastomycosis and phaeohyphomycosis.

https://doi.org/10.1590/0074-02760220089

15.

Repercussões da infodemia associada ao COVID-19 na saúde mental do idoso no Brasil
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Bezerra Cavalcante, Ricardo

; da Costa Carbogim, Fabio

; Fávero Bulgarelli, Alexandre

; Mello dos Santos, Camila

; Queiroz Ribeiro, Andréia

; Carvalho Pinto, Ione

; Machado Zacharias, Fabiana Costa

; Aparecida Fabriz, Luciana

; Moura de Oliveira, Deíse

; Toledo de Mendonça, Erica

; Ricardo Moreira, Tiago

; Miranda Machado, Richardson

; Ribeiro Bitencourt, Graziele

; Alfradique de Souza, Priscilla

; Fereira Santana, Rosimere

; Cabreira Panitz Cruz, Gylce Eloisa

; Rezende Freitas, Eduarda

; Salmazo da Silva, Henrique

; Viana Cruz, Fabiana

; Silva Fhon, Jack Roberto

; Shizuê Kitamura, Elisa

; Gonçalves Leite, Isabel Cristina

; Rodrigues Braz, Patricia

; Consolação dos Santos, Regina

; Prado Rocha, Flávia

; Aparecida Silva, Eveline

; Barreiros Tavares, Thais

; Duarte Martins, Jerusa Gonçalves

; Alves de Araújo Püschel, Vilanice

Revista Cubana de Información en Ciencias de la Salud

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2022, Volume 33 elocation e1871

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO: O fenômeno denominado infodemia refere-se ao aumento do volume informacional sobre um tema em específico, que se multiplica rapidamente em um curto período de tempo, e tem-se destacado frente ao contexto da crise sanitária desencadeada pela pandemia de COVID-19. O excesso de informações pode suscitar sentimentos de medo, ansiedade, estresse e outras condições de sofrimento mental. O estudo tem como objetivo descrever o perfil de exposição a informações sobre COVID-19 e suas repercussões na saúde mental de idosos brasileiros. Trata-se de um estudo transversal realizado com 1924 idosos brasileiros. Coletaram-se dados por meio de web-based survey enviada aos idosos por redes sociais e e-mail, no período de julho a outubro de 2020. Os resultados da análise descritiva dos dados demonstram que a maioria dos idosos apresentou idade entre 60 e 69 anos (69,02%), é do sexo feminino (71,26%), casados (53,79%) e de cor branca (75,57%). Cerca de 21,67% (n = 417) concluíram a graduação, 19,75% (380) concluíram especialização e 16,63% (320) concluíram mestrado ou doutorado. Foram reportados como fontes frequentes de exposição às notícias ou informações sobre a COVID-19, a televisão 862 (44,80%) e as redes sociais 651 (33,84%). Os participantes assinalaram que a televisão (46,47%; n = 872), as redes sociais (30,81%; n = 575) e o rádio (14,48%; 251) os afetavam psicológica e/ou fisicamente. Receber notícias falsas sobre a COVID-19 pela televisão (n = 482; 19,8%) e pelas redes sociais (n = 415; 21,5%) repercutiu, principalmente, estresse e medo. As informações disseminadas contribuem para conscientização, mas, também, afetam física e/ou psicologicamente muitos idosos, principalmente gerando medo e estresse.

ABSTRACT The phenomenon called infodemia refers to the increase in the volume of information on a specific topic, which multiplies rapidly in a short period of time, and has stood out in the context of the health crisis triggered by the COVID-19 pandemic. Too much information can trigger feelings of fear, anxiety, stress, and other conditions of mental distress. The study aims to describe the profile of exposure to information about COVID-19 and its repercussions on the mental health of elderly Brazilians. This is a cross-sectional study carried out with 1924 elderly Brazilians. Data were collected through a web-based survey sent to the elderly via social networks and email, from July to October 2020. The results of the descriptive analysis of the data show that most of the elderly were aged between 60 and 69 years (69.02%), female (71.26%), married (53.79%) and white (75.57%). About 21.67% (n = 417) concluded their graduation, 19.75% (380) concluded their specialization and 16.63% (320) concluded their master's or doctoral degrees. Television 862 (44.80%) and social networks 651 (33.84%) were reported as frequent sources of exposure to news or information about COVID-19. Participants indicated that television (46.47%; n = 872), social networks (30.81%; n = 575) and radio (14.48%; 251) affected them psychologically and/or physically. Receiving fake news about COVID-19 on television (n = 482; 19.8%) and on social media (n = 415; 21.5%) mainly resulted in stress and fear. The disseminated information contributes to awareness, but also affects physically and/or psychologically many elderly people, mainly generating fear and stress.

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