Resumen Esta investigación tiene como objetivo principal verificar las relaciones entre los estilos de crianza predominantes, las dimensiones de la coparentalidad y los problemas de conducta de los niños con trastorno del espectro autista (TEA). Es de tipo exploratorio, descriptivo y correlacional, en la que participaron padres (n=45) y madres (n=45) de niños diagnosticados con TEA, con una edad media de 59 meses. Los datos fueron recolectados en el Centro Especializado de Rehabilitación Física e Intelectual en el sur de Brasil. Primero, se aplicó un cuestionario sociodemográfico y luego se aplicaron los siguientes instrumentos a cada miembro de la pareja: Cuestionario sobre las Dimensiones de los Estilos de Crianza, Escala de Relación Coparental y Cuestionario de Capacidad y Dificultades. A través de análisis de correlación estadística, se descubrió que los estilos de crianza permisivos y autoritarios se asociaron con una relación coparental negativa con poco apoyo de la pareja, exposición a conflictos y un boicot a las funciones parentales. Además, este tipo de relación coparental tuvo una relación positiva con los problemas de conducta de los niños con TEA. Esta investigación avanza el conocimiento de estudios en el campo de la crianza de los hijos al destacar la relación bidireccional entre el comportamiento de los niños con TEA y los subsistemas parental y coparental. Sin embargo, los resultados no pueden generalizarse a todas las familias de niños con TEA, debido al tamaño limitado de la muestra y a los instrumentos y análisis utilizados.

Resumo Esta pesquisa leve como principal objetivo verificar as relações entre os estilos parentais predominantes, as dimensões da coparentalidade e os problemas de comportamento em crianças com transtomo do espectro autista (TEA). Caracterizou-se como de caráter exploratório, descritivo e correlacionai, da qual participaram pais (n=45) e mães (n=45) de crianças diagnosticadas com TEA com média de idade de 59 meses. Os dados foram coletados no Centro Especializado em Reabilitação Física e Intelectual, no Sul do Brasil. Primeiramente, foi aplicado um questionário socio demográfico e. posteriormente, aplicaram-se. com cada membro do casal, os seguintes instrumentos: Questionário de Dimensões dos Estilos Parentais, Escala da Relação Coparental e Questionário de Capacidades e Dificuldades. Por meio de análises estatísticas de correlação, constatou-se que os estilos parentais permissivo e autoritário foram associados a uma relação coparental negativa com pouco apoio do(a) companheiro (a), exposição a conflitos e boicote das funções parentais. Além disso, esse tipo relação coparental teve relação positiva com problemas de comportamento da criança com TEA. Esta pesquisa avança no conhecimento dos estudos no campo da parentalidade por evidenciar a relação bidirecional do comportamento da criança com TEA e os subsistemas parental e coparental. Contudo, os resultados não podem ser generalizados para todas as familias de crianças com TEA, devido à limitação do número da amostra e aos instrumentos e análises empregados.

Abstract This research had as main objective to verify the relationships between the predominant parenting styles, the dimensions of coparenting and the behavior problems in children with Autistic Spectrum Disorder (ASD). This investigation is characterized as exploratory, descriptive and correlational. Fathers (n=45) and mothers (n=45) of children diagnosed with ASD, with a mean age of 59 months, participated. Data were collected at the Specialized Center for Physical and Intellectual Rehabilitation in southern Brazil. First, a sociodemographic questionnaire was applied and then the following instruments were applied to each member of the couple: Questionnaire on Dimensions of Parenting Styles, Coparental Relationship Scale and Capacity and Difficulties Questionnaire. Through statistical correlation analyzes, it was found that the permissive and authoritarian parenting styles were associated with a negative coparental relationship with little partner support, exposure to conflicts and a boycott of parental functions. In addition, this type of coparental relationship had a positive relationship with behavioral problems of children with ASD. This research advances the knowledge of studies in the field of parenting by highlighting the bidirectional relationship between the behavior of children with ASD and the parental and coparental subsystems. However, the results cannot be generalized to all families of children with ASD, due to the limited sample size, instruments and analyzes used.

Abstract Flow accelerated corrosion (FAC) is a steel degradation that occurs in heat recovery steam generators in the power industry. The mechanism of this corrosion comprises an electrochemical dissolution of the semi-protective magnetite layer (Fe3O4) that is formed within the pipes employed in the boilers. The FAC is influenced by different factors such as fluid velocity, pH and dissolved oxygen concentration. In this context, Rotating Cage tests were used to evaluate the influence of pH and dissolved oxygen content on FAC of A210, P11 and P22 steels. General corrosion was lower for P11 and P22 steels, an effect consistent with the presence of chromium in their compositions. General corrosion was most critical at pH 8.5. The corrosion intensity decreased for the three steels when the dissolved oxygen concentration increased, at 2 m/s. This behavior is coherent considering the most effective precipitation of Fe2O3 inside the pores of the Fe3O4 layer in a more oxidizing environment. For 3 m/s, the corrosion intensity increased for both materials when oxygen increased, showing the shear stress effect. These behaviors were more significant at pH 8.5. About pitting corrosion, the analyzes show localized attack in the majority of coupons, however with very low number of pits.

RESUMO Esse trabalho mostra uma rota sintética mediada por tetraetilenoglicol (P. E. 325°C) em que utiliza o ácido túngstico, como material de partida. A formação de uma suspensão estável de cor azul foi observada durante o curso da reação. O tamanho das partículas depende do tempo de síntese, sendo que partículas de tamanho em torno de 400 nm foram obtidas após 15 minutos de reação em tetraetilenoglicol. Os materiais particulados foram então recozidos em diferentes temperaturas: 150°, 350°C, 500°C e 800°C, e caracterizados por TGA / DSC, DRX, FT-RAMAN, MEV, Espectroscopia óptica UV-VIS e adsorção de N2 a 77K. Observou-se que a síntese proporcionou WO3 sob fase ortorrômbica que evoluiu para monoclínica após tratamento térmico na temperatura igual ou superior a 350°C. A caracterização morfológica indicou a formação de partículas ovoides quando tratadas em temperaturas em torno de 500°C, temperatura a partir da qual a área superficial diminui drasticamente. A atividade fotocatalítica para a degradação de rodamina B (rhB, 10 mg.L-1) foi avaliada sob irradiação ultravioleta (6 Watts). Maior atividade foi encontrada para o material tratado a 500°C, sendo que descoramento foi total após 180 minutos na presença de 10 mg desse catalisador.

ABSTRACT This work shows a synthetic route mediated by tetraethylene glycol (P. E. 325 ° C) in which tungstic acid is used as the starting material. The formation of a stable blue suspension was observed during the course of the reaction. The size of the particles depends on the synthesis time, and particles of size around 400 nm were obtained after 15 minutes of reaction in tetraethylene glycol. The particulate materials were then annealed at different temperatures: 150 °, 350 ° C, 500 ° C and 800 ° C, and characterized by TGA / DSC, DRX, FT-RAMAN, MEV, UV-VIS optical spectroscopy and N2 adsorption at 77K. It was observed that the synthesis provided WO3 under orthorhombic phase that evolved to monoclinic after heat treatment at a temperature equal to or greater than 350 ° C. The morphological characterization indicated the formation of ovoids particles when treated at temperatures around 500 ° C, a temperature from which the surface area decreases dramatically. The photocatalytic activity for the degradation of rhodamine B (rhB, 10 mg.L-1) was evaluated under ultraviolet irradiation (6 Watts). Greater activity was found for the material treated at 500 ° C, with total discoloration after 180 minutes in the presence of 10 mg of this catalyst.

RESUMO Objetivou-se com o presente trabalho avaliar durante três ciclos de produção, os teores de nutrientes e a eficiência nutricional em Palma forrageira ‘Gigante’ submetida a diferentes adubações química, orgânica e organomineral, configurações de plantio e espaçamentos. Setenta e dois tratamentos, envolvendo dois tipos de arranjos nas parcelas, três espaçamentos nas subparcelas e 12 tipos de adubação nas sub-subparcelas foram dispostos em esquema de parcelas sub-subdivididas, em delineamento experimental em blocos casualizados, com três repetições. Na época da colheita de cada ciclo produtivo, coletaram-se 40 amostras de tecidos dos cladódios por tratamento para determinação da massa de matéria seca e dos teores de nutrientes e a partir destes calcularam-se os coeficientes de utilização biológica dos nutrientes. Verificou-se que a adubação orgânica diminui os teores de Mn nos cladódios abaixo da faixa de suficiência. A eficiência nutricional de N, P, S, Mn e Zn é maior com adubação orgânica e organomineral e estão associadas às maiores produtividades de matéria seca, enquanto de K é maior com adubação mineral. A ausência de adubação ou aplicação de 30 Mg ha-1 ano-1 de esterco bovino é insuficiente para assegurar o estado nutricional e produtividade de matéria seca acima de 15 Mg ha-1 em palma forrageira ‘Gigante’.

ABSTRACT The objective of this study was to evaluate nutrient concentration and nutritional efficiency in ‘Gigante’ cactus pear under different chemical, organic and organomineral fertilizations, planting configurations and spacings, during three production cycles. Seventy two treatments, involving two types of configuration in the plots, three spacings in the subplots and 12 types of fertilization in the sub-subplots were arranged in a split-split-plot scheme, in a randomized block design, with three repetitions. At the time of harvest of each production cycle, 40 cladode tissue samples were collected per treatment to determine dry matter mass and nutrient concentration, which were used to calculate the coefficients of biological utilization of nutrients. Organic fertilization reduces Mn concentrations in cladodes to levels below the sufficiency range. The nutritional efficiency of N, S, P, Mn and Zn is higher with organic and organomineral fertilizations and are associated with higher dry matter yields, whereas K nutritional efficiency is higher with mineral fertilization. The absence of fertilization or application of 30 Mg ha-1 year-1 of bovine manure is insufficient to ensure nutritional status and dry matter yield above 15 Mg ha-1 in ‘Gigante’ cactus pear.

Abstract Osteoporosis is a metabolic disorder characterized by a loss of bone mass and structure and increasing the risk of fragility fractures, mostly among postmenopausal women. Sheep is a recognized large animal model for osteoporosis research. An experimental group of ewes (3-4 years old) was subjected to ovariectomy (OVX) and weekly glucocorticoid (GC) application for 24 weeks and compared with a sham control group. Blood and bone marrow parameters were analyzed before and 24 weeks after OVX and GC administration. Osteopenia was confirmed through micro-computed tomography and histomorphometric analysis of L4 vertebra in the study end. A statistically significant increase was observed in mean corpuscular volume, mean cell hemoglobin and monocytes and a decrease in red blood count and eosinophils (p<0.05). Alkaline phosphatase (ALP), gamma-glutamyl transpeptidase, magnesium and α1-globulin increased, and creatinine, albumin, sodium and estradiol decreased (p<0.05). A slight decrease of bone formation markers (bone ALP and osteocalcin) and an increase of bone resorption markers (C-terminal telopeptides of collagen type 1 and tartrate-resistant acid phosphatase) were observed, but without statistical significance. This study aims to contribute to better knowledge of sheep as a model for osteoporosis research and the consequences that a performed induction protocol may impose on organic metabolism.

RESUMO A palma forrageira é adaptada às condições semiáridas. Neste trabalho, objetivou-se avaliar em três ciclos de produção, a eficiência do uso da água e as produtividades de massa verde e matéria seca, da cultivar Gigante sob diferentes doses e fontes de adubação, espaçamento e arranjos de plantas. Setenta e dois tratamentos, envolvendo dois arranjos nas parcelas, três espaçamentos nas subparcelas e 12 tipos de adubação nas sub-subparcelas foram dispostos em esquema de parcelas sub-subdivididas, em delineamento em blocos casualizados, com três repetições. O teor de matéria seca decresce e a eficiência do uso da água e as produtividades de massa verde e matéria seca aumentam do primeiro para o terceiro ciclo. É viável o uso de configurações de plantio em fileiras triplas ou quádruplas que possibilitam aumentar o índice de mecanização na cultura. As adubações organominerais com 30 ou 60 Mg ha-1 ano-1 de esterco bovino combinadas com 150-300-600 kg ha-1 ano-1 de N-P2O5-K2O e 300-300 kg ha-1 ano-1 de P2O5-K2O, respectivamente, adubação orgânica com 90 Mg ha-1 ano-1 de esterco bovino e adubação mineral com 300-300-600 kg ha-1 ano-1 de N-P2O5-K2O proporcionam produtividades de massa verde e de matéria seca maiores que 200 e 15 Mg ha-1 ciclo-1, respectivamente, e eficiência de uso da água maior que 20 kg ha-1 mm-1 em palma forrageira ‘Gigante’. Conclui-se que produtividades dessa ordem são asseguradas com aplicação de cerca de 300-300-300 kg ha-1 ano-1 de N-P2O5-K2O com fontes orgânica, organomineral ou mineral.

ABSTRACT Cactus pear is adapted to semi-arid conditions. In this study, the objective was to evaluate the water use efficiency and green and dry mass yields of the cultivar Gigante under different fertilization rates and sources in three production cycles, spacing and planting arrangement. Seventy two treatments, involving two types of arrangements in the plots, three spacings in the subplots and 12 types of fertilization in the sub-subplots were arranged in a split-split-plot scheme, using randomized block design with three repetions. Dry mass content decreases while water use efficiency and green mass and dry mass yields increase from the first to the third cycle. It is feasible to use planting arrangements in triple or quadrupling rows which allow increasing the mechanization index of the crop. Organomineral fertilization with 30 or 60 Mg ha-1 year-1 of bovine manure combined with 150-300-600 kg ha-1 year-1 of N-P2O5-K2O and 300-300 kg ha-1 year-1 of P2O5-K2O, respectively; organic fertilization with 90 Mg ha-1 year-1 of manure; and mineral fertilization with 300-300-600 kg ha-1 year-1 of N-P2O5-K2O ensure green mass and dry mass yields greater than 200 and 15 Mg ha-1 cycle-1, respectively, and water use efficiency greater than 20 kg ha-1 mm-1 in ‘Gigante’ cactus pear. It is concluded that yields of this magnitude are ensured with application of about 300-300-300 kg ha-1 year-1 of N-P2O5-K2O using organic, organomineral or mineral sources.

ABSTRACT Plants are considered among the main sources of biologically active chemicals. The species Solidago chilensis Meyen, Asteraceae, is native to the southern parts of South America, where the aerial parts of the plant are commonly used for the treatment of inflammatory conditions. However, the effects of S. chilensis on human cancer cells remain to be elucidated. In this study, we evaluated the antiproliferative effects of the hydroalcoholic and dichloromethane extracts of S. chilensis, as well as their chemical constituents quercitrin and solidagenone against the five human tumor cell lines in vitro. The dichloromethane extract showed a promisor antiproliferative effects in vitro, especially against glioma cell line. Besides, the hydroalcoholic extract and quercitrin were inactive. The diterpene solidagenone showed highly potent antiproliferative effects against breast (MCF-7), kidney (786-0), and prostate cancer (PC-3) cells (total growth inhibition: TGI < 6.25 µg/ml). Solidagenone meets the theoretical physico-chemical criteria for bioavailability of drugs, according to the "Rule of Five" and, by theorical studies, the observed biological effects were probably related to the interaction of the molecule with nuclear receptors and as an enzymatic inhibitor. This study contributes to chemical study and to the identification of antiproliferative molecules in S. chilensis.

The secondary metabolites of the aerial parts of Phyllanthus acuminatus Vahl (Phyllanthaceae) and the biological activity of one of them were characterized in this study. This chemical investigation led to isolation of two lignans, luclaricin (1), a new arylnaphtalene-typelignan, and justicidin B (2). The structures of isolated compounds were determined based on 1D and 2D-NMR, HRESIMS and IR. The cytotoxic activity of justicidin B was assessed against tumor cell lines (MCF-7, U251, NCI-ADR/RES, NCI-H460, OVCAR-3, HT29 and K562) and a non-tumor cell line (HaCat) using sulforhodamine B assay. Justicidin B showed strong cytotoxic activity against the tumor cell lines HT29, K562 and U251 with GI50 values of 2.28, 3.29 and 5.76 mol L-1, respectively.

Introdução:A espondilodiscite tem uma apresentação heterogénea, tornando o diagnóstico, por vezes, um desafio. Os autores caracterizam e avaliam a prevalência de espondilodiscite num serviço de Medicina Interna. População/Métodos: Estudo retrospetivo observacional de todos os doentes com diagnóstico de espondilodiscite à data da alta, entre 2007 e 2016. Avaliaram-se: variáveis demográficas; forma de apresentação; fatores de risco; local de infeção; agente isolado e tratamento efetuado. Resultados: Identificaram-se 33 casos de espondilodiscite (19 homens; idade média 77,0 ± 15,5 anos), perfazendo uma prevalência de 0,3%. Os sintomas de apresentação mais frequentes foram dor dorso-lombar, febre e alterações neurológicas. Doze doentes apresentavam infeção concomitante, oito diabetes mellitus, quatro neoplasia e três doença hepática crónica. Quatro doentes foram submetidos a cirurgia há Staphylococcus aureus meticilino-sensível (MSSA) e num Mycobacterium tuberculosis. O esquema de antibioterapia foi: vancomicina e ciprofloxacina nos doentes com culturas estéreis ou positivas a MRSA, meropenem ou piperacilina/tazobactam e ciprofloxacina quando positivas a E. coli ESBL, e flucloxacilina quando positivas a MSSA. A duração média de tratamento foi de 5 semanas. Conclusão: O doente com espondilodiscite é idoso, com co-morbilidades. Os exames imagiológicos são essenciais uma vez que os sintomas e as alterações laboratoriais podem estar ausentes.

Introduction: Clinical presentation of spondylodiscitis is heterogeneous. Its diagnosis is sometimes challenging. The authors characterize and evaluate the prevalence of spondylodiscitis in a Department of Internal Medicine (DIM). Population/Methods: Observational retrospective study of all patients with spondylodiscitis diagnosis at discharge from 2007 to 2016. Demographic variables, presentation symptoms, risk factors, site of infection, etiology and management were accessed. Results: Thirty three cases of spondylodiscitis (19 men, mean age 77 ± 15.5 years) were identified, performing a prevalence of 0.3%. The more frequent symptoms at presentation were flank pain, fever and neurological disorders. Twelve patients had concomitant infection, eight diabetes mellitus and four cancer. Four patients undergone surgery < 6 months, three had chronic hepatic disease and one was an intravenous drug consumer. Twenty-five patients had elevated leukocyte count and/or RCP. Twenty-one patients underwent magnetic resonance imaging (MRI) and computed tomography (CT) scan, six only MRI, four only CT scan and one only positron emission tomography. Fifteen patients underwent biopsy. The most frequent location was the lumbar spine at L4-S1. In 11 patients blood cultures were positive for Escherichia coli ESBL, Staphylococcus aureus methicillin-resistant (MRSA) or methicillin-sensitive Staphylococcus aureus (MSSA) and in one biopsy identified Mycobacterium tuberculosis. The antibiotic scheme was vancomycin and ciprofloxacin for patients with MRSA and negative cultures, meropenem or piperacillin/ tazobactam and ciprofloxacin for patients with E. coli ESBL, flucloxacillin for patients with MSSA. The average duration of treatment was 5 weeks. Conclusion: Patients with spondylodiscitis are older patients with co-morbidities. Imagiologic studies are essential for diagnosis as symptoms and laboratory changes may be absent.

Eumops patagonicus possui como limite leste de distribuição a província de Missiones na Argentina. Essa nota reporta a ampliação do limite leste de distribuição desta espécie e descreve o primeiro registro em Santa Catarina. Os indivíduos foram capturados no litoral norte do Estado, em ecossistema de Restinga. O registro amplia em 610 km o limite leste de distribuição e corresponde ao primeiro registro confirmado em Santa Catarina e na costa brasileira.

Eumops patagonicus has its eastern range limit in Misiones, Argentina. We report the extension of the easternmost range limit of E. patagonicus and describe the first record for this species from Santa Catarina, Southern Brazil. The individuals were captured in the northern coast of the state, in a Restinga ecosystem. Records described herein extend the species’ range 610 km east and are the first from the state of Santa Catarina and along the Brazilian coast.

Abstract Natural products are a major source of drugs for the treatment of cancer. The species Alpinia zerumbet (Pers.) B.L. Burtt & R.M. Sm, Zingiberaceae, is widely distributed in Brazil where it is known as “colônia”. The leaves are commonly used in the treatment of hypertension and dyspepsia, however, the effects of A. zerumbet extracts and isolated substances on human cancer cells remain to be elucidated. This study was designed to identify the chemical constituents of hydroalcoholic and dichloromethane extracts from A. zerumbet leaves and to investigate their in vitro antiproliferative activity. The isolated phytochemicals included kaempferol, dihydro-5,6-dehydrokavain, 5,6-dehydrokavain, and pinostrobin. The hydroalcoholic extract inhibited cellular proliferation only at high concentrations, while the dichloromethane extract showed a moderate antiproliferative effect against leukemia and lung tumor cell lines. 5,6-Dehydrokavain showed potent cytostatic activity against glioblastoma cells and a moderate effect on all other tumor cell lines. Pinostrobin showed potent activity against leukemia and breast tumor cell lines and moderate cytostatic effect against ovarian cell. Furthermore, this is the first report on the isolation of kaempferol and pinostrobin from A. zerumbet leaves. Moreover, the purification process described in this study was effective. These results suggest that A. zerumbet leaves are a promising source of anticancer compounds.

The quantum mechanics of two electrons atoms, as suggested by E. A. Hylleraas in the period between 1928-1930, is discussed in the present work. Hylleraas introduced explicit correlations in the wavefunction by treating the coordinates between the electrons as an independent variable of the problem, an approach that gives very precise energy values. Solution of the problem is given for one, two, three and six basis functions, as in the original work. The solution is also carried out with 140 basis functions, showing that the energy for two electron atoms can be calculated with seven significant figures. Numerical methods presented here are accessible to undergraduated level students.

Pterodon pubescens Benth., popularly known as "sucupira", is traditionally used as pain healing agent for many inflammatory diseases. The present study evaluated the in vivo antinociceptive and anti-inflammatory properties of sucupira's fruit dicloromethane extract (Pp) compared to the aqueous extract (Ppa) traditionally used in folk medicine. Extracts' chemical characterization was performed by gas chromatography coupled to mass spectra (GC-MS) detection. The standardized extracts were evaluated using antinociceptive and anti-inflammatory experimental models with mice. The results reported herein allowed establishing a relationship between the popular use of Pterodon pubescens fruit for pain relief and the activity of two major compounds isolated from this species which demonstrated antinociceptive activity. The experimental models corroborate activity of aqueous extract antinociceptive and anti-inflammatory activity, with lower potency compared to dichloromethane extract. Nevertheless the resulting data corroborates sucupira's folk use for pain relief.

ABSTRACT The cultivation of sugarcane hybrids (X Saccharum officinarum L.) is an important revenue source for the Brazilian economy. Herein it is reported the evaluation of the cytotoxic activity of mid-polarity sugarcane extracts against human cancer cell lines, as well as the isolation of steroids sitosterol, stigmasterol and campesterol, phenolic acids p-hydroxybenzoic, p-hydroxycinnamic, vanillic and ferulic acid, terpenoids α-tocopherol and β-carotene and a novel substance in sugarcane, the flavonoid aglycone tricin (5,7,4-trihydroxy-3,5-dimethoxyflavone). The presence of large amounts of phenolic acids and the flavonoid tricin may explain the cytostatic activity observed for the mid-polarity crude extract and filtrates.

A series of β-carboline derivatives with amino or guanidinium were synthesized and evaluated in vitro against anti-Mycobacterium tuberculosis and for antiproliferative activities against nine human cancer cell lines. The compounds 1-(4-hydroxyphenyl)-3-carboxamide(ethylamine) β-carboline (24.9 µg mL-1) and 1-(4-methoxyphenyl)-3-carboxamide(ethylamine) β-carboline (26.9 µg mL-1) were the most active against M. Tuberculosis (MTB). Compounds 1-(4-hydroxyphenyl)-3-carboxamide(ethylamine) β-carboline and 1-(4-methoxyphenyl)-3-carboxamide(propylamine) β-carboline, which had the same substituted groups, inhibited the growth of all human tumor cell lines with growth inhibitory activity (GI50) values from 1.37 to 9.20 mmol L-1. Also in this series, compounds 1-(4-hydroxyphenyl)-3-carboxamide(propylamine) β-carboline and 1-(3-nitrophenyl)-3-carboxamide(propylamine) β-carboline demonstrated significant activity against NCI/ADR cells. Among compounds with a terminal guanidine group, compounds 1-(4-hydroxyphenyl)-3-carboxamide(ethyl)guanidine β-carboline (27.8 µg mL-1) and 1-(3-nitrophenyl)-3-carboxamide(ethyl)guanidine β-carboline (37.4 µg mL-1) demonstrated the greatest activity against MTB. Additionally, compounds 1-(4-methoxyphenyl)-3-carboxamide(ethyl)guanidine β-carboline (GI50 = 0.45 mmol L-1) effectively inhibited growth and was highly selective against NCI/ADR. The in silico study revealed that 1-(4-hydroxyphenyl)-3-carboxamide(ethylamine) β-carboline, 1-(4-methoxyphenyl)-3-carboxamide(ethylamine) β-carboline, 1-(4-hydroxyphenyl)-3-carboxamide(propylamine) β-carboline, 1-(4-methoxyphenyl)-3-carboxamide(propylamine) β-carboline and 1-(3-nitrophenyl)-3-carboxamide(propylamine) β-carboline compounds follow the rules established by Lipinski, suggesting that this compound has no problems with oral bioavailability.