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Abstract The sugary cassava cultivar BRS 438 has high roots yield (with expressive concentration of free sugars), adaptation to mechanized planting, and moderate resistance to bacterial diseases. These characteristics make it an option for production of sugars, alcohol, and animal feed (additive in forage grass silage), among other possibilities.

https://doi.org/10.1590/1984-70332023v23n4c37

Atualização da Diretriz Brasileira de Hipercolesterolemia Familiar – 2021
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Izar, Maria Cristina de Oliveira

; Giraldez, Viviane Zorzanelli Rocha

; Bertolami, Adriana

; Santos Filho, Raul Dias dos

; Lottenberg, Ana Maria

; Assad, Marcelo Heitor Vieira

; Saraiva, José Francisco Kerr

; Chacra, Ana Paula M.

; Martinez, Tania L. R.

; Bahia, Luciana Ribeiro

; Fonseca, Francisco Antonio Helfenstein

; Faludi, Andre Arpad

; Sposito, Andrei C.

; Chagas, Antônio Carlos Palandri

; Jannes, Cinthia Elim

; Amaral, Cristiane Kovacs

; Araújo, Daniel Branco de

; Cintra, Dennys Esper

; Coutinho, Elaine dos Reis

; Cesena, Fernando

; Xavier, Hermes Toros

; Mota, Isabela Cardoso Pimentel

; Giuliano, Isabela de Carlos Back

; Faria Neto, José Rocha

; Kato, Juliana Tieko

; Bertolami, Marcelo Chiara

; Miname, Marcio Hiroshi

; Castelo, Maria Helane Costa Gurgel

; Lavrador, Maria Sílvia Ferrari

; Machado, Roberta Marcondes

; Souza, Patrícia Guedes de

; Alves, Renato Jorge

; Machado, Valeria Arruda

; Salgado Filho, Wilson

Arquivos Brasileiros de Cardiologia

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oct 2021, Volume 117 N. 4 Pages 782 - 844

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20210788 231 downloads

Análisis del papel de la vitamina D en la defensa inmunitaria contra la COVID-19 en los adultos mayores
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Pedreáñez Santana, Adriana Beatriz

; Muñóz Castelo, Nelson Enrique

; Tene Salcan, Diego Mauricio

; Robalino Congacha, Jorge Guillermo

Revista Virtual de la Sociedad Paraguaya de Medicina Interna

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sep 2021, Volume 8 N. 2 Pages 76 - 88

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

ABSTRACT Coronavirus disease 2019 (COVID-19) was announced as a global pandemic by the World Health Organization on February 11, 2020. From that moment, challenges have arisen regarding how to optimally support the immune system in the general population, and especially in older adults. There is much evidence that the severity of SARS-CoV-2 infections varies widely with age, being generally more severe in the elderly. An optimal immune response depends on proper diet and nutrition to adequately counter the infection. Several studies have shown the importance of vitamin D as a key factor in regulating immune responses. In this review, we analyze the role of vitamin D in the immune response during SARS-CoV-2 infection with special emphasis on older adults.

RESUMEN La enfermedad por coronavirus 2019 (COVID-19) fue anunciada como una pandemia mundial por la Organización Mundial de la Salud el 11 de febrero de 2020. A partir de ese momento han surgido desafíos con respecto a cómo apoyar de manera óptima el sistema inmunitario en la población en general, y especialmente en los adultos mayores. Existen muchas evidencias de que la gravedad de las infecciones por SARS-CoV-2 varía ampliamente con la edad, siendo generalmente más severa en los ancianos. Una respuesta inmunitaria óptima depende de una dieta y nutrición adecuadas para contrarrestar adecuadamente la infección. Varios estudios han demostrado la importancia de la vitamina D como un factor clave en la regulación de las respuestas inmunitarias. En esta revisión, analizamos el papel de la vitamina D en la respuesta inmunitaria durante la infección por SARS-CoV-2 con especial énfasis en los adultos mayores.

https://doi.org/10.18004/rvspmi/2312-3893/2021.08.02.76 389 downloads

PATENT DUCTUS ARTERIOSUS CLOSURE: EXPERIENCE FROM A TERTIARY REFERRAL CENTER
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Faim, Diogo Remi Oliveira

; Tiago, Joaquim António Maia

; Castelo, Rui Jorge Simões

; Francisco, Andreia Sofia Santos

; Alves, Rosa Ramalho

; Pires, António Manuel Guerra Santos

Revista Paulista de Pediatria

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2021, Volume 39 elocation e2020013

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Caraterizar o número e métodos de fechamento de canal arterial durante 16 anos numa maternidade de nível terciário. Métodos: Estudo retrospetivo de nascidos entre 01 de janeiro de 2003 a 31 de dezembro de 2018 submetidos a fechamento do canal arterial por métodos farmacológico, cirúrgico e/ou percutâneo. Avaliaram-se idade gestacional, sexo, peso ao nascimento, número de fechamentos por ano e método utilizado. Aferiram-se as taxas de sucesso de método farmacológico e de mortalidade e sua associação com peso ao nascer, fármaco utilizado e insucesso do fechamento. Resultados: Verificaram-se 47.198 recém-nascidos, 5.156 prematuros, dos quais 325 com canal arterial patente, sendo 106 com indicação para fechamento (idade gestacional mediana 27 semanas, peso <1000 g em 61%). Verificou-se diminuição do número de fechamentos ao longo dos anos, sobretudo a partir de 2010. O fechamento ocorreu em 62% após primeiro ciclo de tratamento farmacológico e em 74% após segundo. Após insucesso farmacológico, 12 realizaram ligadura cirúrgica e dois, fechamento percutâneo. Houve indicação de ligadura cirúrgica exclusiva em quatro. O ibuprofeno substituiu a indometacina em 2010. O acetaminofen foi usado em três doentes. A mortalidade nos 106 pacientes foi de 12%, associando-se ao peso ao nascer (13/65 <1000 vs. 0/41 >1000 g; p=0,002) e à falha do primeiro ciclo de tratamento farmacológico (13/27 com falha vs. 0/75 com sucesso; p<0,001). Conclusões: Consenso nacional de 2010 para diagnóstico e tratamento do canal arterial nos prematuros levou à diminuição do número de fechamentos desse canal. O fechamento farmacológico foi o método mais utilizado, seguido da ligadura cirúrgica. Peso <1000 g e falha no primeiro ciclo de fechamento farmacológico se associaram à maior mortalidade.

ABSTRACT Objective: To characterize the number and methods of closure of Persistent Ductus Arteriosus (PDA) over a span of 16 years in a third level maternity hospital. Methods: Retrospective study of neonates born between January 2003 and Deccember 2018, who underwent ductus arteriosus closure by pharmacological, surgical and/or transcatheter methods. Gestational age, birth weight, number and methods of closures per year were evaluated. The success rate of the pharmacologic method was calculated, as well as the mortality rate. The association between mortality and birthweight, treatment used and treatment failure was explored. Results: There were 47,198 births, 5,156 were preterm, 325 presented PDA and 106 were eligible for closure (median gestational age - 27 weeks, birthweight <1000 g - 61%). Frequency of PDA closure decreased during the study period, especially starting in 2010. Success rate with pharmacologic treatment was 62% after the first cycle and 74% after the second. After drug failure, 12 underwent surgical ligation and two underwent transcatheter closure. Exclusive surgical ligation was indicated in four infants. Ibuprofen replaced indomethacin in 2010, and acetaminophen was used in three infants. Among the 106 infants, hospital mortality was 12% and it was associated with birthweight <1000 g (13/65 <1000 vs. 0/41 >1000 g; p=0.002) and with failure in the first pharmacologic treatment cycle (13/27 with failure, vs. 0/75 without failure; p<0.001). Conclusions: The national consensus published in 2010 for the diagnosis and treatment of PDA in preterm infants led to a decrease in the indication for closure. Pharmacological closure was the method of choice, followed by surgical ligation. Birthweight <1000 g and first cycle of pharmacologic treatment failure were associated with higher mortality.

https://doi.org/10.1590/1984-0462/2021/39/2020013 1155 downloads

Bouter LM, Zielhuis GA, Zeegers MPA. Textbook of Epidemiology. Houten: Bohn Stafleu van Loghum; 2018.
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Machado, Carla Jorge

; Borges, Isabela Colem Castelo

Ciência & Saúde Coletiva

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feb 2020, Volume 25 N. 2 Pages 773 - 775

Abstract: Pt | Text: Pt | PDF: Pt

https://doi.org/10.1590/1413-81232020252.03392019

Bouter LM, Zielhuis GA, Zeegers MPA. Textbook of Epidemiology. Houten: Bohn Stafleu van Loghum; 2018.
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Machado, Carla Jorge

; Borges, Isabela Colem Castelo

Ciência & Saúde Coletiva

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feb 2020, Volume 25 N. 2 Pages 773 - 775

Abstract: Pt | Text: Pt | PDF: Pt

https://doi.org/10.1590/1413-81232020252.03392019 348 downloads

ANTIBIOTICS FOR APPENDICECTOMY IN CHILDREN AND ADOLESCENTS DURING THE PERIOPERATIVE PERIOD: AN INTEGRATIVE REVIEW
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Roque, Fátima Maria Castelo Branco

; Melo Filho, Antônio Aldo

; Roque, Alberto Jorge Castelo Branco

; Roque, Hanne Castelo Branco

; Moreira, Thereza Maria Magalhães

; Chaves, Edna Maria Camelo

Revista Paulista de Pediatria

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dec 2019, Volume 37 N. 4 Pages 494 - 502

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Analisar o uso de antibióticos em crianças e adolescentes no perioperatório de apendicectomia. Fonte de dados: Realizou-se uma revisão integrativa, nas bases de dados MEDLINE, Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS) e Cochrane e no portal PubMed, sem limite de tempo. As palavras-chave utilizadas foram: apendicite, criança, adolescente e antibacterianos com booleano AND. Os artigos incluídos foram publicados nos idiomas português, inglês ou espanhol e cujos participantes tivessem idade inferior a 18 anos. Os artigos de revisão e diretrizes foram excluídos. A qualidade da evidência foi analisada, e foram selecionados 24 artigos. Síntese dos dados: Sobre os estudos selecionados, sete foram ensaios clínicos randomizados (nível de evidência II), oito coortes (nível III), sete observacionais retrospectivos (nível V) e duas análises documentais históricas (nível IV). Os estudos abordaram antibióticos usados na apendicite aguda em suas formas não complicada e complicada. Os antibióticos iniciados no pré-operatório evidenciaram diminuição nas taxas de infecção da ferida cirúrgica. Os esquemas de primeira linha (empíricos) foram testados em relação à sensibilidade dos microrganismos nas culturas de material peritoneal, no entanto os resultados foram controversos. Sugeriram-se antibióticos de amplo espectro em alguns estudos por apresentar boa cobertura, no entanto em outros eles não foram recomendados, pelo risco de desenvolver resistência bacteriana. O menor tempo de administração e a mudança mais precoce para a via oral reduziram o tempo de internação. Conclusões: Existe um grande número de protocolos clínicos com antibióticos diversos, no entanto não existe padronização em relação ao tipo de antibiótico, tempo de uso nem via.

ABSTRACT Objective: To analyze the preoperative use of antibiotics in children and adolescents requiring appendectomy. Data source: Integrative review was performed in the MEDLINE, Latin American and Caribbean Health Sciences (LILACS) and Cochrane databases and the PubMed portal, with no time limit. The keywords used were: appendicitis, child, adolescent and antibacterial with Boolean AND. The articles included were published in Portuguese, English or Spanish and whose participants were under 18 years of age. Review articles and guidelines were excluded. The studies were classified according to their level of evidence and 24 papers were selected. Data collection and analysis: Seven randomized clinical trial studies (level of evidence II), eight cohorts (level III), seven retrospective observational studies (level V) and two historical documentary analysis (level IV) were selected. The studies addressed antibiotics used in acute appendicitis in both uncomplicated and complicated cases. Antibiotics initiated in the preoperative period showed a decrease in the rates of surgical wound infections. First-line (empiric) regimens were tested for sensitivity to microorganisms in peritoneal material cultures, however the results were controversial. Broad-spectrum antibiotics have been suggested in some studies because they have good coverage, but in others they have not been recommended because of the risk of developing bacterial resistance. Shorter administration time and earlier change to the oral route reduced hospitalization time. Conclusions: There are several clinical protocols with different antibiotics. However, there is no standardization concerning the type of antibiotic drug, time of use, or route.

https://doi.org/10.1590/1984-0462/;2019;37;4;00013 4582 downloads

Centro de Referência e Treinamento DST/AIDS-SP. Coordenadoria de Controle de Doença, Secretaria de Estado da Saúde de São Paulo. Guia de bolso para o manejo de sífilis em gestante e sífilis congênita. 2ª Edição. São Paulo: Secretaria de Estado da Saúde; 2016.
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Borges, Isabela Colem Castelo

; Machado, Carla Jorge

Ciência & Saúde Coletiva

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nov 2019, Volume 24 N. 11 Pages 4367 - 4368

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1413-812320182411.00392019 1398 downloads

10.

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Borges, Isabela Colem Castelo

; Machado, Carla Jorge

Ciência & Saúde Coletiva

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nov 2019, Volume 24 N. 11 Pages 4367 - 4368

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1413-812320182411.00392019

11.

Sobre a distância entre a “situação colonial” em Moçambique e o luso-tropicalismo: carta de António Rita Ferreira para Jorge Dias, com artigo anexo
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Castelo, Cláudia

; Alves, Vera Marques

Etnográfica

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jun 2019, Volume 23 N. 2 Pages 417 - 438

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Este in memoriam revela que num artigo que ficou inédito, enviado em carta a Jorge Dias, António Rita Ferreira criticou a falta de fundamentação sociológica do luso-tropicalismo em Moçambique. Acrescenta densidade à figura do antropólogo amador que ficou conhecido pela polémica com Marvin Harris, mostra a cumplicidade entre os dois antropólogos portugueses, não obstante os seus diferentes percursos e perspetivas, e confirma as potencialidades da correspondência privada enquanto fonte histórica.

This in memoriam reveals that in an unpublished article attached to a letter to Jorge Dias, António Rita Ferreira criticized the lack of sociological foundation of the luso-tropicalism in Mozambique. It adds density to the figure of the amateur anthropologist who became known for the controversy with Marvin Harris, unveils the complicity between the two Portuguese anthropologists, despite their different paths and perspectives, and confirms the potentialities of private correspondence as historical source.

463 downloads

12.

Castro M. A praga: o holocausto da hanseníase. Histórias emocionantes de isolamento, morte e vida nos leprosários do Brasil. São Paulo: Geração Editorial; 2017.
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Borges, Isabela Colem Castelo

; Machado, Carla Jorge

Ciência & Saúde Coletiva

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apr 2019, Volume 24 N. 4 Pages 1571 - 1572

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1413-81232018244.14512018

13.

Castro M. A praga: o holocausto da hanseníase. Histórias emocionantes de isolamento, morte e vida nos leprosários do Brasil. São Paulo: Geração Editorial; 2017.
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Borges, Isabela Colem Castelo

; Machado, Carla Jorge

Ciência & Saúde Coletiva

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apr 2019, Volume 24 N. 4 Pages 1571 - 1572

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1413-81232018244.14512018 1302 downloads

14.

Previous hepatitis E virus infection, cirrhosis and insulin resistance in patients with chronic hepatitis C
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Bricks, Guilherme

; Senise, Jorge Figueiredo

; Pott-Jr, Henrique

; Grandi, Giuliano

; Carnaúba-Jr, Dimas

; Moraes, Hamilton Antonio Bonilha de

; Granato, Celso Franscisco Hernandes

; Castelo, Adauto

Brazilian Journal of Infectious Diseases

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jan 2019, Volume 23 N. 1 Pages 45 - 52

Abstract: En | Text: En | PDF: En

ABSTRACT Background: Hepatitis E virus (HEV) infection in patients with pre-existing liver disease has shown high morbidity and lethality. The consequences of HEV superinfection in patients with chronic hepatitis C virus (HCV) infection are not fully understood. This study aimed to evaluate the association between the presence of anti-HEV antibodies, liver cirrhosis, and insulin resistance. Methods: A total of 618 patients chronically infected with HCV were included from three reference centers for viral hepatitis in São Paulo, Brazil. Presence of anti-HEV IgG was assessed by enzyme-linked immunosorbent assay (WANTAI HEV-IgG ELISA). Results: The seroprevalence of anti-HEV in patients with cirrhosis was significantly higher than in patients without cirrhosis (13.2% vs 8%, OR = 1.74, p = 0.04). Seropositivity for anti-HEV, adjusted for sex, age, and HCV genotype showed an association trend with hepatic cirrhosis (aOR = 1.75, p = 0.059). Presence of HEV antibodies, adjusted for age, body mass index and cirrhosis, was shown to be independently associated with insulin resistance (aOR: 4.39; p = 0.045). Conclusion: Patients with chronic hepatitis C are under risk of hepatitis E virus superinfection in Brazil. The trend toward association between cirrhosis and previous HEV infection suggests that it may accelerate liver fibrosis in patients with chronic hepatitis C. In addition, previous infection by HEV is independently associated with insulin resistance in the studied population, which may be an extra-hepatic manifestation of hepatitis E that persists after resolution of the active infection, and may contribute to fibrosis progression.

https://doi.org/10.1016/j.bjid.2019.02.002 599 downloads

15.

Encefalopatía Posterior Reversible En El Contexto De La Eclampsia. Reporte De Caso Y Revisión De La Literatura
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Unigarro, Luis Javier

; Torres, Liliana

; Castelo,, Marcelo

; Sánchez, Freddy

; Feliz, Daniel

; Mora, Alejandro

; Rivera, Carlos

; Mascialino, Guido

; Ortiz-Prado, Esteban

; Vascones, Jorge E.

Revista Ecuatoriana de Neurología

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aug 2018, Volume 27 N. 2 Pages 70 - 78

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract Posterior reversible encephalopathy syndrome (PRES) is a rare neurological disorder characterized by headaches, visual disturbances, altered level of consciousness, seizures, and a variety of neurological deficits that are caused by a severe increase in blood pressure. Hypertensive disorders of pregnancy, mainly preeclampsia and eclampsia, continue to be one of the main causes of morbidity and mortality during pregnancy worldwide, causing neurological complications ranging from singular seizures to the development of status epilepticus and the advent of potentially fatal cerebrovascular events. We describe the presentation of posterior reversible encephalopathy syndrome in a pregnant adolescent who developed a hypertensive disorder of pregnancy.

Resumen El síndrome de la encefalopatía posterior reversible conocido como (PRES) es un trastorno neurológico caracterizado por cefalea, alteraciones visuales, deterioro del estado de consciencia, crisis convulsivas y déficits neurológicos variados que tienen como causa, el incremento severo de la presión arterial. Los trastornos hipertensivos del embarazo, principalmente la preeclampsia y eclampsia, siguen siendo una de las causas principales de la morbilidad y mortalidad durante el embarazo, causando complicaciones neurológicas que van desde las crisis convulsivas únicas hasta el desarrollo de estatus convulsivos y del advenimiento de eventos cerebrovasculares potencialmente mortales. Describimos la presentación del síndrome de encefalopatía posterior reversible en una adolescente embarazada quien desarrolló un trastorno hipertensivo del embarazo.

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