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ABSTRACT BACKGROUND: Brazil is facing increasing cycles of numbers of infected people and deaths resulting from coronavirus disease 2019 (COVID-19). This situation involves a series of factors, including the behavior of the population, that can be decisive for controlling the disease. OBJECTIVE: To determine the knowledge, attitudes and practices of the Brazilian population regarding COVID-19. DESIGN AND SETTING: Cross-sectional survey-type study, conducted using a population sample from different Brazilian states. METHODS: A quantitative, descriptive and analytical approach was used. Sampling was done according to convenience and via snowballing. The data collection instrument was a knowledge, attitudes and practices system. RESULTS: 1,655 people from all over Brazil participated in the survey; 80% were living in the southern region and 70.15% were female. More than 90% had knowledge and good attitudes relating to the means of transmission, preventive care and symptoms associated with COVID-19, although their knowledge and attitudes were not fully reflected in daily practices, for which there was lower adherence (80%). Greater knowledge was correlated with older participants, larger number of children, female sex and marital status; better attitude, with female sex and complete higher education; and better practices, with greater age, larger number of children and female sex. CONCLUSION: A large part of the population has general knowledge about COVID-19, but not all knowledge was applied in practice. Older people, females and university graduates stood out as the best informed and most committed to controlling the disease.

https://doi.org/10.1590/1516-3180.2021.0541.23072021

Integrated analysis of label-free quantitative proteomics and bioinformatics reveal insights into signaling pathways in male breast cancer
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Gomig, Talita Helen Bombardelli

; Gontarski, Amanda Moletta

; Cavalli, Iglenir João

; Souza, Ricardo Lehtonen Rodrigues de

; Lucena, Aline Castro Rodrigues

; Batista, Michel

; Machado, Kelly Cavalcanti

; Marchini, Fabricio Klerynton

; Marchi, Fabio Albuquerque

; Lima, Rubens Silveira

; Urban, Cícero de Andrade

; Marchi, Rafael Diogo

; Cavalli, Luciane Regina

; Ribeiro, Enilze Maria de Souza Fonseca

Genetics and Molecular Biology

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2021, Volume 44 N. 1 elocation e20190410

Abstract: En | Text: En | PDF: En

Abstract Male breast cancer (MBC) is a rare malignancy that accounts for about 1.8% of all breast cancer cases. In contrast to the high number of the “omics” studies in breast cancer in women, only recently molecular approaches have been performed in MBC research. High-throughput proteomics based methodologies are promisor strategies to characterize the MBC proteomic signatures and their association with clinico-pathological parameters. In this study, the label-free quantification-mass spectrometry and bioinformatics approaches were applied to analyze the proteomic profiling of a MBC case using the primary breast tumor and the corresponding axillary metastatic lymph nodes and adjacent non-tumor breast tissues. The differentially expressed proteins were identified in the signaling pathways of granzyme B, sirtuins, eIF2, actin cytoskeleton, eNOS, acute phase response and calcium and were connected to the upstream regulators MYC, PI3K SMARCA4 and cancer-related chemical drugs. An additional proteomic comparative analysis was performed with a primary breast tumor of a female patient and revealed an interesting set of proteins, which were mainly involved in cancer biology. Together, our data provide a relevant data source for the MBC research that can help the therapeutic strategies for its management.

https://doi.org/10.1590/1678-4685-gmb-2019-0410 790 downloads

Basic knowledge about visceral leishmaniasis before and after educational intervention among primary health care professionals in Midwestern Brazil
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Carvalho, Amanda Gabriela de

; Alves, Isaac

; Borges, Larissa Marquiori

; Spessatto, Laura Bordignon

; Castro, Ludiele Souza

; Luz, João Gabriel Guimarães

Revista do Instituto de Medicina Tropical de São Paulo

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2021, Volume 63 elocation e56

Abstract: En | Text: En | PDF: En

ABSTRACT Health education and training of primary health care (PHC) professionals are highly recommended to reduce the occurrence and lethality of visceral leishmaniasis (VL). This study assessed the impact of an educational intervention on the basic knowledge about visceral leishmaniasis (VL) among PHC professionals from the Brazilian municipality of Rondonopolis, an important endemic area for VL. Responses provided by physicians, nurses, nursing technicians and community health agents from 12 PHC facilities were recorded through the application of self-completed and semi-structured questionnaires before (n=92) and after (n=64) an in-person health training course covering various aspects of VL. Closed- and open-ended responses were compared by the chi-square test and analyses of word clouds, respectively. The proportion of professionals aware of the correct etiological agent (p<0.001) and transmission route (p<0.001) of VL increased post-intervention. In addition, they increased their ability to recognize fever (p<0.001), weakness (p<0.001), weight loss (p<0.001), pallor (p<0.001) and abdominal distention (p=0.013) as clinical manifestations of human VL, and weakness (p<0.001), alopecia (p<0.001) and weight loss (p=0.019) as signs of canine VL. Analyses of word clouds suggested that the participants became more aware of the role of dogs in VL transmission and the role of environmental management in the prevention of VL. In conclusion, the intervention positively impacted the baseline knowledge concerning VL among the professionals. This can support the planning of educational activities for the PHC team regarding early case detection, prevention and control of VL in endemic areas.

https://doi.org/10.1590/s1678-9946202163056 206 downloads

Establishment of a simple and efficient platform for car-t cell generation and expansion: from lentiviral production to in vivo studies
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Picanço-Castro, Virgínia

; Moço, Pablo Diego

; Mizukami, Amanda

; Vaz, Leticia Delfini

; Pereira, Marcelo de Souza Fernandes

; Silvestre, Renata Nacasaki

; Azevedo, Júlia Teixeira Cottas de

; Bomfim, Aline de Sousa

; Abreu Neto, Mario Soares de

; Malmegrim, Kelen Cristina Ribeiro

; Swiech, Kamilla

; Covas, Dimas Tadeu

Hematology, Transfusion and Cell Therapy

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jun 2020, Volume 42 N. 2 Pages 150 - 158

Abstract: En | Text: En | PDF: En

ABSTRACT Introduction: Adoptive transfer of T cells expressing a CD19-specific chimeric antigen receptor (CAR) has shown impressive response rates for the treatment of CD19 + B-cell malignancies in numerous clinical trials. The CAR molecule, which recognizes cell-surface tumor-associated antigen independently of human leukocyte antigen (HLA), is composed by one or more signaling molecules to activate genetically modified T cells for killing, proliferation, and cytokine production. Objectives: In order to make this treatment available for a larger number of patients, we developed a simple and efficient platform to generate and expand CAR-T cells. Methods: Our approach is based on a lentiviral vector composed by a second-generation CAR that signals through a 41BB and CD3-ζ endodomain. Conclusions: In this work, we show a high-level production of the lentiviral vector, which was successfully used to generate CAR-T cells. The CAR-T cells produced were highly cytotoxic and specific against CD19+ cells in vitro and in vivo, being able to fully control disease progression in a xenograft B-cell lymphoma mouse model. Our work demonstrates the feasibility of producing CAR-T cells in an academic context and can serve as a paradigm for similar institutions. Nevertheless, the results presented may contribute favoring the translation of the research to the clinical practice.

https://doi.org/10.1016/j.htct.2019.06.007 548 downloads

Impacto da qualidade da atenção primária à saúde na redução das internações por condições sensíveis
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Castro, Dayanna Mary de

; Oliveira, Veneza Berenice de

; Andrade, Amanda Cristina de Souza

; Cherchiglia, Mariângela Leal

; Santos, Alaneir de Fátima dos

Cadernos de Saúde Pública

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2020, Volume 36 N. 11 elocation e00209819

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo: O objetivo foi analisar a associação entre a qualidade da atenção primária à saúde (APS) nos municípios brasileiros e o número de internações por condições sensíveis à atenção primária. Trata-se de estudo ecológico, com análise de dados secundários de abrangência nacional. A qualidade da APS foi aferida com base na avaliação do Programa Nacional de Melhoria do Acesso e da Qualidade da Atenção Básica (PMAQ-AB). A análise foi realizada por meio de um modelo explicativo hierarquizado, tendo sido o número de internações por condições sensíveis à atenção primária no ano de 2014 considerado como variável dependente, e os dados sociodemográficos e os relacionados ao sistema de saúde como variáveis independentes. A medida de associação entre o número de hospitalizações e a qualidade da APS foi calculada por regressão binomial negativa com variância robusta e população total como offset, tendo sido considerada significância de 20% na análise univariada e 5% na multivariada. A quantidade média de internações por condições sensíveis à atenção primária no período analisado foi de 359,97 internações por município. A qualidade da APS mostrou associação negativa com o número de internações por condições sensíveis à atenção primária. Municípios com menor nível de qualidade (quartil 1) apresentaram 21,2% mais de internações por condições sensíveis à atenção primária do que municípios mais bem avaliados (IC95%: 1,09-1,34). Os resultados mostraram que a qualidade da APS do país teve impacto na redução das internações por condições sensíveis à atenção primária, mesmo em contextos de vulnerabilidade social.

Abstract: This study aimed to analyze the association between quality of primary healthcare (PHC) in Brazilian municipalities (counties) and the number of hospitalizations due to primary healthcare-sensitive conditions. This was an ecological study with analysis of nationwide secondary data. The quality of the number of hospitalizations due to primary healthcare-sensitive conditions was based on assessment of the National Program for Improvement of Access and Quality of Basic Care (PMAQ-AB). The analysis used a hierarchical explanatory model, with the number of the number of hospitalizations due to primary healthcare-sensitive conditions hospitalizations in the year 2014 as the dependent variable and sociodemographic and health system data as the independent variables. The measure of association between the number of hospitalizations and quality of PHC was calculated with negative binomial regression with robust variance and the total population as offset, with significance set at 20% in the univariate analysis and 5% in the multivariate analysis. The mean number of hospitalizations due to primary healthcare-sensitive conditions admissions during the target period was 359.97 hospitalizations per municipality. The quality of PHC showed a negative association with the number of hospitalizations due to primary healthcare-sensitive conditions admissions. Municipalities with lower quality of PHC (quartile 1) showed 21.2% more number of hospitalizations due to primary healthcare-sensitive conditions admissions than municipalities with higher quality (95%CI: 1.09-1.34). The results showed that quality of PHC in Brazil reduced hospitalizations due to primary healthcare-sensitive conditions, even in contexts of social vulnerability.

Resumen: El objetivo fue analizar la asociación entre la calidad de la atención primaria a la salud (APS) de los municipios brasileños y el número de internamientos por condiciones delicadas de salud en la atención primaria (ICSAP por sus siglas en portugués). Se trata de un estudio ecológico, con análisis de datos secundarios de alcance nacional. La calidad de la APS se midió en base a la evaluación del Programa Nacional de Mejoría de Acceso y Calidad de la Atención Básica (PMAQ-AB). El análisis se realizó mediante un modelo explicativo jerarquizado, siendo considerado el número de internamientos por condiciones delicadas de salud en la atención primaria, durante el año de 2014, como variable dependiente, y los datos sociodemográficos, así como los relacionados con el sistema de salud, como variables independientes. La medida de asociación entre el número de hospitalizaciones y la calidad de la APS se calculó por regresión binomial negativa con variancia robusta, y la población total como offset, habiendo sido considerada una significancia de un 20% en el análisis univariado y un 5% en el multivariado. La cantidad media de ICSAP durante el período analizado fue de 359,97 internamientos por municipio. La calidad de la APS mostró una asociación negativa con el número de internamientos por condiciones delicadas de salud en la atención primaria. Municipios con menor nivel de calidad (cuartil 1) presentaron un 21,2% más número de internamientos por condiciones delicadas de salud en la atención primaria que los municipios mejor evaluados (IC95%: 1,09-1,34). Los resultados mostraron que la calidad de la APS del país tuvo un impacto en la reducción de los números de internamientos por condiciones delicadas de salud en la atención primaria, incluso en contextos de vulnerabilidad social.

https://doi.org/10.1590/0102-311x00209819

Impacto da qualidade da atenção primária à saúde na redução das internações por condições sensíveis
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Castro, Dayanna Mary de

; Oliveira, Veneza Berenice de

; Andrade, Amanda Cristina de Souza

; Cherchiglia, Mariângela Leal

; Santos, Alaneir de Fátima dos

Cadernos de Saúde Pública

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2020, Volume 36 N. 11 elocation e00209819

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

https://doi.org/10.1590/0102-311x00209819 1032 downloads

Social representations of health professionals about terminally ill children and adolescents
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Fernandes, Fernanda de Souza

; Ferraz, Fabiane

; Salvaro, Giovana Ilka Jacinto

; Castro, Amanda

; Soratto, Jacks

Revista CEFAC

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dec 2018, Volume 20 N. 6 Pages 742 - 752

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: compreender as representações sociais dos profissionais de saúde sobre a terminalidade infantojuvenil. Métodos: trata-se de um estudo de abordagem qualitativa, do tipo exploratório descritivo, realizado com 10 profissionais de saúde, selecionados mediante a técnica de coleta de dados de amostragem em rede. Os instrumentos para coleta de dados foram entrevistas semiestruturadas e associação livre de palavras. A análise dos dados seguiu os passos da análise de conteúdo, sendo subsidiada pela teoria das representações sociais, com auxílio do software Atlas.ti. Resultados: a análise das entrevistas apresentou 115 trechos de narrativas, condensados em 11 códigos os quais foram agrupados em 3 categorias: experiências, estratégias e consequências do convívio com a terminalidade; missão e amorosidade em situação terminal; terminalidade como término da vida. A associação livre de palavras resultou em 52 evocações com destaque para sofrimento, dor, amor missão e família. Conclusão: as representações sociais dos profissionais de saúde sobre a terminalidade infantojuvenil estão associadas às experiências das situações vivenciadas; as estratégias desenvolvidas para enfrentamento desses momentos no exercício da profissão; e, as consequências que esta vivência oportuniza aos profissionais de saúde.

ABSTRACT Purpose: to understand the social representations of health professionals about terminally ill children and adolescents in different work settings. Methods: a qualitative, descriptive, exploratory study was conducted with ten health professionals, selected through the technique of network sampling. The instruments for data collection were semi-structured interviews, and free association of words. The analysis of the data followed the steps of content analysis, subsidized by the theory of social representations, with the support of Atlas.ti software. Results: the analysis of the interviews presented 115 excerpts of statements, condensed into 11 codes, which were grouped into three categories: experiences, strategies, and consequences of conviviality with terminality; mission and amorousness in a terminal condition; terminality as the end of life. The free association of words resulted in 52 evocations, with an emphasis on suffering, pain, love, mission, and family. Conclusion: the social representations of health professionals about terminally ill children and adolescents are associated with the situations being experienced, the strategies developed to deal with these moments in the exercise of the profession, and the consequences that this experience causes in the health professionals.

https://doi.org/10.1590/1982-021620182062618 1667 downloads

Activity of the antimicrobial peptide P34 against bovine alphaherpesvirus type 1
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Castro, Clarissa Caetano de

; Silva, Débora Scopel e

; Costa, Géssica Aracéli

; Fischer, Geferson

; Vargas, Gilberto D’Avila

; Brandelli, Adriano

; Lima, Marcelo de

; Motta, Amanda de Souza da

; Hübner, Silvia de Oliveira

Ciência Rural

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2017, Volume 47 N. 6 elocation e20160668

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: A atividade antimicrobiana do peptídeo P34 já foi previamente demonstrada. Neste estudo, o potencial antiviral do P34 e o mecanismo de ação in vitro contra o alfaherpesvírus bovino tipo 1 (BoHV1) foram investigados. O P34 exibiu baixa toxicidade, alto índice de seletividade (22.9) e percentagem de inibição viral de até 100% em células MDBK. Os resultados dos ensaios antivirais indicaram que não interage com receptores celulares, mas é capaz de inibir a penetração viral, imediatamente após a pré-adsorção. Além disso, a curva de crescimento do BoHV1 em células MDBK na presença do P34 revelou uma significativa redução no título somente após 8h de infecção, sugerindo também uma importante atividade do peptídeo nas fases finais do ciclo replicativo. Efeito virucida frente / BoHV1 foi observado apenas em concentrações citotóxicas do peptídeo. Os dados obtidos indicam que o peptídeo antimicrobiano P34 pode ser considerado um potencial composto inibidor de herpesvírus, in vitro, e estimulam posteriores investigações sobre sua atividade anti-herpética em modelos animais, bem como contra outros vírus.

ABSTRACT: Previous studies have demonstrated the antimicrobial activity of the peptide P34. In this study, the antiviral potential of P34 and the in vitro mechanism of action were investigated against bovine alphaherpesvirus type 1 (BoHV1). P34 exhibited low toxicity, a high selectivity index (22.9) and a percentage of inhibition of up to 100% in MDBK cells. Results from antiviral assays indicated that P34 did not interact with cell receptors, but it was able to inhibit the viral penetration immediately after pre-adsorption. In addition, BoHV1 growth curve in MDBK cells in the presence of P34 revealed a significant reduction in virus titer only 8h post-infection, also suggesting an important role at late stages of the replicative cycle. Virucidal effect was observed only in cytotoxic concentrations of the peptide. These findings showed that the antimicrobial peptide P34 may be considered as a potential novel inhibitor of in vitro herpesviruses and must encourage further investigation of its antiherpetic activity in animal models as well as against a wide spectrum of viruses.

https://doi.org/10.1590/0103-8478cr20160668 1126 downloads

Diversity and Efficiency of Rhizobia Communities from Iron Mining Areas Using Cowpea as a Trap Plant
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Castro, Jordana Luísa de

; Souza, Mariana Gonçalves

; Rufini, Márcia

; Guimarães, Amanda Azarias

; Rodrigues, Tainara Louzada

; Moreira, Fatima Maria de Souza

Revista Brasileira de Ciência do Solo

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2017, Volume 41 elocation e0160525

Abstract: En | Text: En | PDF: En

ABSTRACT Mining is an important economic activity. However, its impact on environment must be accessed, mainly on relevant processes for their sustainability. The objective of this study was to evaluate the diversity and efficiency of symbiotic nitrogen fixing bacterial communities in soils under different types of vegetation in the Quadrilátero Ferrífero: ironstone outcrops, Atlantic Forest, neotropical savanna, and a rehabilitated area revegetated with grass. Suspensions of soil samples collected under each type of vegetation were made in a saline solution to capture rhizobia communities that were then inoculated on cowpea [Vigna unguiculata (L.) Walp.], which was used as a trap plant. The symbiotic efficiency of the communities was evaluated in a greenhouse experiment and the data obtained were correlated to the chemical and physical properties of the soils under each type of vegetation. At the end of the experiment, the bacteria present in the nodules were isolated to evaluate their diversity. The highest numbers of nodules occurred in the treatment inoculated with soil samples from rehabilitated area revegetated with grass and neotropical savanna vegetation, and the lowest numbers were observed in the treatment inoculated with soil samples from ironstone outcrops and Atlantic Forest. In relation to root dry matter, the treatment inoculated with soil samples from Neotropical savanah was superior to those inoculated with soil samples from the other areas; already, in relation to the shoot dry matter, no significant difference among the treatments was observed. The soil properties with the greatest influence on the microbial communities were Al3+ content, considered as high in the Atlantic Forest and neotropical savanna vegetation, as intermediate in the iron outcrops, and as very low in the rehabilitated area revegetated with grass; organic matter, considered as very high in the ironstone outcrops and neotropical savanna, as high in the Atlantic Forest, and as low in the rehabilitated area revegetated with grass; and the pH, with intermediate acidity level in the rehabilitated area revegetated with grass, high level of acidity in the iron outcrops and neotropical savanna, and very high acidity in the Atlantic Forest. After isolation of the nodules, 380 bacterial strains were obtained and separated into 27 groups by cultural characterization analysis. Genetic diversity was evaluated by the 16S rRNA gene partial sequencing of 156 strains, which identified some bacteria belonging to nitrogen-fixing Leguminosae nodulating bacterial genera (Rhizobium, Bradyrhizobium, Burkholderia, and Cupriavidus), some representative of associative bacteria (Bacillus, Paenibacillus, Herbaspirillum, Pseudomonas, and Agrobacterium), and other genera (Brevibacillus, Novosphingobium, Chitinophaga, Dyella, Acinetobacter, and Stenotrophomonas). The highest genetic diversity of bacteria was found in the rehabilitated area revegetated with grass indicated that it was effective in soil rehabilitation

https://doi.org/10.1590/18069657rbcs20160525 1890 downloads

10.

A workshop on asthma management programs and centers in Brazil: reviewing and explaining concepts
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Stelmach, Rafael

; Neto, Alcindo Cerci

; Fonseca, Ana Cristina de Carvalho Fernandez

; Ponte, Eduardo Vieira

; Alves, Gerardo

; Araujo-Costa, Ildely Niedia

; Lasmar, Laura Maria de Lima Belizário Facury

; Castro, Luci Keiko Kuromoto de

; Lenz, Maria Lucia Medeiros

; Silva, Paulo

; Cukier, Alberto

; Alves, Alexssandra Maia

; Lima-Matos, Aline Silva

; Cardoso, Amanda da Rocha Oliveira

; Fernandes, Ana Luisa Godoy

; São-José, Bruno Piassi de

; Riedi, Carlos Antônio

; Schor, Deborah

; Peixoto, Décio Medeiros

; Brandenburg, Diego Djones

; Camillo, Elineide Gomes dos Santos

; Serpa, Faradiba Sarquis

; Brandão, Heli Vieira

; Lima, João Antonio Bonfadini

; Pio, Jorge Eduardo

; Fiterman, Jussara

; Anderson, Maria de Fátima

; Cardoso, Maria do Socorro de Lucena

; Rodrigues, Marcelo Tadday

; Pereira, Marilyn Nilda Esther Urrutia

; Antila, Marti

; Martins, Sonia Maria

; Guimarães, Vanessa Gonzaga Tavares

; Mello, Yara Arruda Marques

; Andrade, Wenderson Clay Correia de

; Salibe-Filho, William

; Caldeira, Zelina Maria da Rocha

; Cruz-Filho, Álvaro Augusto Souza da

; Camargos, Paulo

Jornal Brasileiro de Pneumologia

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feb 2015, Volume 41 N. 1 Pages 3 - 15

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Objetivo: Relatar os resultados de uma oficina de trabalho sobre programas e centros de atenção a asmáticos (PCAAs) no Brasil para que possam servir como instrumento para melhoria e avanço dos PCAAs existentes e criação de novos. Métodos: A oficina de trabalho constituiu-se de cinco apresentações e discussões em grupos. Os grupos de trabalho discutiram os seguintes temas: implementação de uma linha de cuidado em asma; recursos humanos necessários para os PCAA; recursos necessários para financiar os PCAA; e manutenção do funcionamento dos PCAAs. Resultados: A oficina envolveu 39 participantes de todas as regiões do país, representando associações de asmáticos (n = 3), centros universitários (n = 7) e PCAAs (n = 29). Evidenciou-se uma relação direta entre a ausência de planejamento e o insucesso dos PCAAs. Com base nas experiências brasileiras elencadas durante a oficina, as premissas comuns foram a importância da sensibilização do gestor, maior participação da comunidade, interdependência entre a atenção primária e a especializada, observação da regionalização e utilização dos medicamentos disponíveis no sistema público de saúde. Conclusões: O Brasil já tem um núcleo de experiências na área programática da asma. A implementação de uma linha de cuidado em doenças respiratórias crônicas e sua inclusão nas redes de saúde parecem ser o caminho natural. Porém, a experiência nessa área ainda é pequena. Agregar pessoas com experiência nos PCAAs na elaboração da linha de cuidado em asma encurtaria tempo na criação de redes de atenção com possível efeito multiplicador, evitando que se partisse do zero em cada local isolado.

Objective: To report the results of a workshop regarding asthma management programs and centers (AMPCs) in Brazil, so that they can be used as a tool for the improvement and advancement of current and future AMPCs. Methods: The workshop consisted of five presentations and the corresponding group discussions. The working groups discussed the following themes: implementation of asthma management strategies; human resources needed for AMPCs; financial resources needed for AMPCs; and operational maintenance of AMPCs. Results: The workshop involved 39 participants, from all regions of the country, representing associations of asthma patients (n = 3), universities (n = 7), and AMPCs (n = 29). We found a direct relationship between a lack of planning and the failure of AMPCs. Based on the experiences reported during the workshop, the common assumptions about AMPCs in Brazil were the importance of raising awareness of managers; greater community participation; interdependence between primary care and specialized care; awareness of regionalization; and use of medications available in the public health system. Conclusions: Brazil already has a core of experience in the area of asthma management programs. The implementation of strategies for the management of chronic respiratory disease and their incorporation into health care system protocols would seem to be a natural progression. However, there is minimal experience in this area. Joint efforts by individuals with expertise in AMPCs could promote the implementation of asthma management strategies, thus speeding the creation of treatment networks, which might have a multiplier effect, precluding the need for isolated centers to start from zero.

https://doi.org/10.1590/s1806-37132015000100002 4433 downloads

11.

Development and validating an educational booklet for childbirth companions
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Teles, Liana Mara Rocha

; Oliveira, Amanda Souza de

; Campos, Fernanda Câmara

; Lima, Thaís Marques

; Costa, Camila Chaves da

; Gomes, Linicarla Fabiole de Souza

; Oriá, Mônica Oliveira Batista

; Damasceno, Ana Kelve de Castro

Revista da Escola de Enfermagem da USP

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dec 2014, Volume 48 N. 6 Pages 977 - 984

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

Objective The article describes the steps in producing and validating an educational booklet for childbirth companions. Method Methodological study conducted in 2011 consisting of the following steps: situational assessment; establishing brochure content; content selection and referencing; drafting the text; design of illustrations; layout; consultation of specialists; consultation of target audience; amendments; proofreading; evaluation using the Flesch Reading Ease Formula. The topics portrayed the sequence of events involving support from gestation to the postpartum period. Results The concordance rate among companions was greater than or equal to 81.8% for the topics organisation, writing style, presentation and motives. The overall Content Validity Index of the booklet was 0.94. The booklet was classified as easy reading or very easy reading according to the results of the Flesch Reading Ease Formula. Conclusion The presentation and content of the manual were validated for use with the target audience by the specialists and representatives of the target audience.

Objetivo Describir el proceso de construcción y validación de un manual educativo para acompañantes durante el trabajo de parto y el parto. Método Investigación metodológica, realizada en 2011, seguiendo las etapas: diagnóstico situacional; relevamiento del contenido; selección y registro del contenido; elaboración textual; creación de las ilustraciones; diagramación del manual; consulta a expertos; consulta al público meta; adecuación del manual; revisión de portugués y evaluación del Índice de Legibilidad de Flesch (ILF). Fueron planteados los tópicos que retrataron el soporte desde el período gestacional hasta el posparto. Resultados Entre los acompañantes, hubo concordancia mínima del 81,8% en los tópicos organización, escrita, apariencia y motivación. El Índice de Validad de Contenido (IVC) Global del manual educativo fue de 0,94. Desde el ILF, los tópicos del manual correspondieron a la lectura Muy Fácil o Fácil. Conclusión Se considera el manual validado por expertos y representantes del público meta en cuanto a su apariencia y contenido.

Objetivo Descrever o processo de construção e validação de um manual educativo para acompanhantes durante o trabalho de parto e parto. Método Pesquisa metodológica, realizada em 2011, seguindo as etapas: diagnóstico situacional; levantamento do conteúdo; seleção e fichamento do conteúdo; elaboração textual; criação das ilustrações; diagramação do manual; consulta a especialistas; consulta ao público-alvo; adequação do manual; revisão de português e avaliação do Índice de Legibilidade de Flesch (ILF). Foram elaborados tópicos que retrataram o suporte do período gestacional ao pós-parto. Resultados Entre os acompanhantes, houve concordância mínima de 81,8% nos tópicos organização, escrita, aparência e motivação. O Índice de Validade de Conteúdo (IVC) Global do manual educativo foi de 0,94. A partir do ILF, os tópicos do manual corresponderam à leitura Muito Fácil ou Fácil. Conclusão Considera-se o manual validado por especialistas e representantes do público-alvo quanto à sua aparência e conteúdo.   

https://doi.org/10.1590/S0080-623420140000700003 2 downloads

12.

Development and validating an educational booklet for childbirth companions
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Teles, Liana Mara Rocha

; Oliveira, Amanda Souza de

; Campos, Fernanda Câmara

; Lima, Thaís Marques

; Costa, Camila Chaves da

; Gomes, Linicarla Fabiole de Souza

; Oriá, Mônica Oliveira Batista

; Damasceno, Ana Kelve de Castro

Revista da Escola de Enfermagem da USP

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dec 2014, Volume 48 N. 6 Pages 977 - 984

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

https://doi.org/10.1590/S0080-623420140000700003 10862 downloads

13.

Antiviral activity of a Bacillus sp: P34 peptide against pathogenic viruses of domestic animals
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Silva, Débora Scopel e

; Castro, Clarissa Caetano de

; Silva, Fábio da Silva e

; Sant'anna, Voltaire

; Vargas, Gilberto D'Avila

; Lima, Marcelo de

; Fischer, Geferson

; Brandelli, Adriano

; Motta, Amanda de Souza da

; Hübner, Silvia de Oliveira

Brazilian Journal of Microbiology

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sep 2014, Volume 45 N. 3 Pages 1089 - 1094

Abstract: En | Text: En | PDF: En

P34 is an antimicrobial peptide produced by a Bacillus sp. strain isolated from the intestinal contents of a fish in the Brazilian Amazon basin with reported antibacterial activity. The aim of this work was to evaluate the peptide P34 for its in vitro antiviral properties against canine adenovirus type 2 (CAV-2), canine coronavirus (CCoV), canine distemper virus (CDV), canine parvovirus type 2 (CPV-2), equine arteritis virus (EAV), equine influenza virus (EIV), feline calicivirus (FCV) and feline herpesvirus type 1 (FHV-1). The results showed that the peptide P34 exhibited antiviral activity against EAV and FHV-1. The peptide P34 inhibited the replication of EAV by 99.9% and FHV-1 by 94.4%. Virucidal activity was detected only against EAV. When P34 and EAV were incubated for 6 h at 37 °C the viral titer reduced from 10(4.5) TCID50 to 10(2.75) TCID50, showing a percent of inhibition of 98.6%. In conclusion, our results demonstrated that P34 inhibited EAV and FHV-1 replication in infected cell cultures and it showed virucidal activity against EAV. Since there is documented resistance to the current drugs used against herpesviruses and there is no treatment for equine viral arteritis, it is advisable to search for new antiviral compounds to overcome these infections.

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14.

Tecnologias utilizadas por acompanhantes no trabalho de parto e parto: estudo descritivo
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Oliveira, Amanda Souza de

; Damasceno, Ana Kelve de Castro

; Moraes, Jamile Lopes de

; Moreira, Karla de Abreu Peixoto

; Teles, Liana Mara Rocha

; Gomes, Linicarla Fabíole de Souza

Online Brazilian Journal of Nursing

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2014, Volume 13 N. 1 Pages 36 - 45

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

Aim: To evaluate the knowledge of companions about the use of support techniques during childbirth. Method: A descriptive, cross-sectional quantitative study undertaken at the Assis Chateaubriand Maternity Hospital with a sample of 62 companions. Data collection was undertaken from May to November 2011, through individual interviews and a survey. The Pearson's chi-square tests and Fisher's exact test for statistical associations were used. Results: 59 (95.2%) of the companions who witnessed the birth did not undergo any training; 32 (51.6%) were selected at the time of entry of the pregnant women in the emergency room; emotional support activities were predominant. The experience of witnessing the birth was considered to be positive on the part of 58 (96%) of the companions. Discussion: the most common relationship between companion and the pregnant woman were mother and daughter respectively. Feelings of insecurity and fear were experienced by some of the companions. Conclusion: the companionâ€™s presence during labor constitutes a major form of care.

Objetivo:verificar el conocimiento que tienen los acompañantes sobre las técnicas de apoyo durante el parto. Método: Estudio descriptivo, transversal y cuantitativo realizado en la Maternidad Escuela Assis Chateaubriand con una muestra de 62 acompañantes. La recolección de datos ocurrió de mayo a noviembre de 2011, por medio de una entrevista individual con la utilización de un formulario. Se utilizaron los tests Chi-cuadrado de Pearson y Test Exacto de Fisher para las asociaciones estadísticas. Resultados: 59 (95,2%) acompañantes que presenciaron el parto no realizaron capacitación; 32 (51,6%) fueron elegidos en el momento de entrada de la mujer embarazada en la emergencia; predominaron actividades de apoyo emocional. La experiencia de tener acompañado el parto fue considerado positivo por 58 (96%) acompañantes. Discusión: las relaciones de parentesco entre el acompañante y la parturiente más frecuentes fueron las de madre e hija. Sentimientos de inseguridad y miedo acompañaron algunos acompañantes. Conclusi

Objetivo:verificar o conhecimento de acompanhantes acerca das técnicas de apoio durante o parto. Método: estudo descritivo, transversal e quantitativo realizado na Maternidade Escola Assis Chateaubriand com amostra de 62 acompanhantes. A coleta de dados correu de maio a novembro de 2011, por meio de entrevista individual com utilização de um formulário. Utilizaram-se os testes Qui-quadrado de Pearson e Teste Exato de Fisher para as associações estatísticas. Resultados: 59 (95,2%) acompanhantes que presenciaram o parto não realizaram capacitação; 32 (51,6%) foram escolhidos no momento de entrada da gestante na emergência; predominaram atividades de apoio emocional. A experiência de ter acompanhado o parto foi considerada positiva por 58 (96%) acompanhantes. Discussão: as relações de parentesco entre acompanhante e parturiente mais frequentes foram mãe e filha. Sentimentos de insegurança e medo acompanharam alguns acompanhantes. Conclusão:o acompanhante durante o parto constitui-se em importante tecnologia de cuidado.

487 downloads

15.

Corrimentos vaginais em gestantes: comparacao da abordagem sindromica com exames da pratica clinica da enfermagem
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Lima, Thais Marques

; Teles, Liana Mara Rocha

; Oliveira, Amanda Souza de

; Campos, Fernanda Camara

; Barbosa, Rita de Cassia Carvalho

; Pinheiro, Ana Karina Bezerra

; Damasceno, Ana Kelve de Castro

Revista da Escola de Enfermagem da USP

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dec 2013, Volume 47 N. 6 Pages 1265 - 1271

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

This is a study for assessment of a quantitative approach in pregnant women (N=104), in which findings of vaginal infection were compared. The findings were obtained by two means, flowchart of vaginal discharge, and typical examinations in the clinical nursing practice. Data were collected from January to July 2011 through interviews and gynecological examinations. The flowchart showed no efficacy to identify candidiasis and trichomoniasis. Furthermore, it showed low sensitivity (0.0%; 50%) and positive predictive value (0.0%; 3.6%) for both infections, and low specificity for trichomoniasis (46%). The flowchart was shown to be satisfactory for bacterial vaginosis, with high sensitivity (100%), negative predictive value (100%), and accuracy (74%). We conclude that use of the flowchart should be reassessed, as it was not able to identify important infections in pregnant women. A continuous effort must be directed for development of effective tests in order to prevent the spread of infection and reduce the number of unnecessary treatments.

Estudio evaluativo con enfoque cuantitativo, con una muestra de 104 gestantes, cuyo objetivo fue comparar los resultados de infecciones vaginales en las gestantes, obtenidos a partir del diagrama de flujo vaginal y las pruebas presentes en la práctica clínica de enfermería. Los datos fueron recolectados por entrevista y examen ginecológico, realizados de enero a julio del 2011. El diagrama de flujo no fue eficaz en la identificación de candidiasis y tricomoniasis, presentando baja sensibilidad (0,0%; 50%) y valor predictivo positivo (0,0%; 3,6%), para las dos infecciones y baja especificidad para tricomoniasis (46%). Para vaginosis bacteriana, se mostró satisfactoria, con alta sensibilidad (100%), valor predictivo negativo (100%) y precisión (74%). Se concluye que el uso del diagrama necesita ser revisado, ya que no fue eficaz en la identificación de infecciones importantes en las gestantes. Los esfuerzos para desarrollar pruebas efectivas deben ser continuos, con el objetivo de prevenir la propagación de infecciones y reducir tratamientos innecesarios.

Estudo avaliativo de abordagem quantitativa, com amostra de 104 gestantes, com o objetivo de comparar os achados de infecções vaginais em gestantes obtidos por meio do fluxograma de corrimento vaginal com exames presentes na prática clínica da Enfermagem. Os dados foram coletados por meio de entrevista e exame ginecológico realizados de janeiro a julho de 2011. O fluxograma não se mostrou eficaz na identificação de candidíase e tricomoníase, apresentou baixa sensibilidade (0,0%; 50%) e valor preditivo positivo (0,0%; 3,6%) para as duas infecções e baixa especificidade para tricomoníase (46%). Mostrou-se satisfatório para vaginose bacteriana, com alta sensibilidade (100%), valor preditivo negativo (100%) e acurácia (74%). Conclui-se que o emprego do fluxograma precisa ser reavaliado, visto que não foi eficaz em identificar infecções importantes em gestantes. Os esforços para o desenvolvimento de testes eficazes devem ser contínuos, com intuito de prevenir a disseminação de infecções e reduzir tratamentos desnecessários.

https://doi.org/10.1590/S0080-623420130000600002 2 downloads

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