ABSTRACT Introduction: On certain occasions work exposes us to common risks, such as food poisoning; This may be due to exposure to unhealthy places of sale, especially in Peru, which still has a poor health system. Objective: To determine whether the type of employment is a risk factor for the diarrhea among workers in fourteen cities in Peru. Materials and Methods: Retrospective and multicenter cohort study. Investigated diarrhea among workers attending their occupational appointments in fourteen cities in Peru. This was associated with the type of work performed. Statistical association was obtained using the generalized linear models. Results: Of the 4057 respondents, 39% had at least one episode of diarrhea in the past year. There was an increased risk of diarrhea in the last year among workers; on the other hand, the risk of employees of mining companies decreased, trade, outsourced transport or the education sector; adjusted for age, type of instruction and daily hygiene. Conclusion: Some types of work generate different risks for the diarrhea, this must be monitored and controlled, since it could have repercussions for the worker and the labor institution.

RESUMEN. Introducción: En ciertas ocasiones el trabajo nos expone a riesgos comunes, como el de una intoxicación alimentaria; esto puede ser por la exposición a lugares de venta no saludables, y más en Perú, que tiene un sistema sanitario aún deficiente. Objetivo: Determinar si el tipo de empleo es un factor de riesgo para el padecimiento de diarrea entre los trabajadores de catorce ciudades del Perú. Material y Métodos: Estudio de cohorte retrospectiva y multicéntrico. Se encuestó acerca del padecimiento de diarrea a trabajadores de catorce ciudades del Perú; esto se asoció según el tipo de trabajo que realizaban, se obtuvo datos estadísticos de asociación mediante los modelos lineales generalizados. Resultados: De los 4057 encuestados, el 39% tuvo al menos un episodio de diarrea en el último año. Existía mayor riesgo de padecer diarrea en los trabajadores operarios; por el contrario, disminuían el riesgo los empleados de empresas mineras, comercio, trasporte o el sector educación; ajustado por la edad, tipo de instrucción y por su higiene diaria. Conclusión: Algunos trabajos generan riesgos para el padecimiento de diarrea, esto debe ser vigilado, ya que, puede afectar a los trabajadores y al centro de trabajo.

RESUMEN. Introducción: En ciertas ocasiones el trabajo nos expone a riesgos comunes, como el de una intoxicación alimentaria; esto puede ser por la exposición a lugares de venta no saludables, y más en Perú, que tiene un sistema sanitario aún deficiente. Objetivo: Determinar si el tipo de empleo es un factor de riesgo para el padecimiento de diarrea entre los trabajadores de catorce ciudades del Perú. Material y Métodos: Estudio de cohorte retrospectiva y multicéntrico. Se encuestó acerca del padecimiento de diarrea a trabajadores de catorce ciudades del Perú; esto se asoció según el tipo de trabajo que realizaban, se obtuvo datos estadísticos de asociación mediante los modelos lineales generalizados. Resultados: De los 4057 encuestados, el 39% tuvo al menos un episodio de diarrea en el último año. Existía mayor riesgo de padecer diarrea en los trabajadores operarios; por el contrario, disminuían el riesgo los empleados de empresas mineras, comercio, trasporte o el sector educación; ajustado por la edad, tipo de instrucción y por su higiene diaria. Conclusión: Algunos trabajos generan riesgos para el padecimiento de diarrea, esto debe ser vigilado, ya que, puede afectar a los trabajadores y al centro de trabajo.

ABSTRACT Introduction: On certain occasions work exposes us to common risks, such as food poisoning; This may be due to exposure to unhealthy places of sale, especially in Peru, which still has a poor health system. Objective: To determine whether the type of employment is a risk factor for the diarrhea among workers in fourteen cities in Peru. Materials and Methods: Retrospective and multicenter cohort study. Investigated diarrhea among workers attending their occupational appointments in fourteen cities in Peru. This was associated with the type of work performed. Statistical association was obtained using the generalized linear models. Results: Of the 4057 respondents, 39% had at least one episode of diarrhea in the past year. There was an increased risk of diarrhea in the last year among workers; on the other hand, the risk of employees of mining companies decreased, trade, outsourced transport or the education sector; adjusted for age, type of instruction and daily hygiene. Conclusion: Some types of work generate different risks for the diarrhea, this must be monitored and controlled, since it could have repercussions for the worker and the labor institution.

SUMMARY: Rheumatoid arthritis (RA) is a disease triggered by environmental and genetic factors. Research suggests that physical exercise has benefits such as delaying functional disability. In vivo studies using experimental models of arthritis can provide useful information about these benefits. to analyze the effects that different intensities of aquatic physical exercise have on the proprieties of the bones in induced arthritis in knees of Wistar rats. Male Wistar adults rats (n=20) were divided into 5 groups: Group Control Arthritis (GCA) n=4, Group control Placebo (GCP) n=4, Group Low Physical Activity (GB) n=4, Group Moderate Physical Activity (GM) n=4 and Group Intense Physical Activity (GI) n=4. The physical activity groups got an intra-articular injection of Zymosam on the right knee; the GCA received saline solution in the right knee; the GCP was submitted to the stress of the needle. The animals were submitted to aquatic activity for 30 minutes, 4 times a week for 5 weeks, and the intensity of the exercise was determined by a weight placed on their back: GB=1 %, GM=5 %, GI=15 % of their body weight. It was observed that the group GB, and the groups that did not exercise GCA and GCP, gained more weight compared to the group GM. In relation to the bone mineral content of the tibia, there was a decrease in the GM group when compared to the GCP group, whereas in the tibial bone mineral density there was a decrease in the GM group compared to the GCP, GCA, GB. As for the area of the femur, the GI group presented an increase of it compared to the GB and GM groups. It is concluded that the high intensity exercises promote better results in bone properties.

RESUMEN: La investigación sugiere que el ejercicio físico tiene beneficios como retrasar la discapacidad funcional de la artritis reumatoide. Los estudios in vivo que utilizan modelos experimentales de artritis pueden proporcionar información útil sobre estos beneficios. Se analizaron los efectos de las intensidades del ejercicio físico acuático sobre las propiedades de los huesos, en la artritis inducida en las rodillas de ratas Wistar. Las ratas Wistar macho adultas (n = 20) se dividieron en 5 grupos: grupo de control artritis (ACG) n = 4, grupo control placebo (CGP) n = 4, grupo de actividad física baja (GB) n = 4, grupo de actividad física moderada (GM) n = 4 y grupo de actividad física intensa (GI) n = 4. Los grupos de actividad física recibieron una inyección intraarticular de Zymosam en la rodilla derecha; el GCA recibió solución salina en la rodilla derecha; el CGP fue sometido a la tensión de una aguja. Los animales fueron sometidos a actividad acuática durante 30 minutos, 4 veces a la semana durante 5 semanas, y la intensidad del ejercicio se determinó mediante un peso colocado sobre su espalda: GB = 1 %, GM = 5 %, GI = 15 % de su peso corporal. Se observó que el grupo GB, y los grupos que no ejercitaron GCA y CGP, ganaron más peso en comparación con el grupo GM. En relación con el contenido mineral óseo de la tibia, hubo una disminución en el grupo GM en comparación con el grupo GCP, mientras que en la densidad mineral del hueso tibial hubo una disminución en el grupo GM en comparación con el GCP, GCA, GB. En cuanto al área del fémur, el grupo GI presentó un aumento en comparación con los grupos GB y GM. En conclusión el ejercicio de alta intensidad promueve mejores resultados en las propiedades óseas.

Abstract Stress cardiomyopathy, or Takotsubo syndrome, is similar to that of an acute coronary syndrome, with electrocardiographic changes and an increase in troponin levels; however, coronary arteriography typically shows no obstructive lesions. One of the characteristic patterns are regional wall motion abnormalities identified by echocardiography. It has been described in association with thyroid disorders, although the causal mechanism is not clearly established. We present the case of a woman with acute chest pain and electrical and analytical changes. A severe ventricular dysfunction was observed but the coronary tree was free of lesions, all of which was compatible with a stress cardiomyopathy. Hyperthyroidism due to Graves’ disease was observed as a trigger. The identification and management of clinical factors that might predispose patients to Takotsubo syndrome or impact on subsequent clinical outcome is mandatory.

Resumen La miocardiopatía de estrés o síndrome de Takotsubo cursa clínicamente igual que un síndrome coronario agudo, con cambios eléctricos compatibles con isquemia y elevación de troponinas, aunque, en la coronariografía las arterias son normales. Su principal característica es el trastorno de la motilidad apical en el ecocardiograma. Se ha descrito en relación a trastornos tiroideos, aunque la relación causal no está claramente establecida. Se presenta el caso de una mujer que comenzó súbitamente con clínica de dolor torácico agudo, con cambios eléctricos y analíticos. Se objetivó una disfunción ventricular severa y un árbol coronario libre de lesiones, compatible con una miocardiopatía de estrés. Como desencadenante, presentó un hipertiroidismo por enfermedad de Graves. La identificación y manejo de los factores clínicos que podrían predisponer a los pacientes a esta miocardiopatía de estrés es fundamental para su prevención y tratamiento.

Abstract AIMS The aim of the present study was to investigate the effects of combined training (CT) on total ghrelin and tumor necrosis factor-α (TNF-α) levels in obese middle-aged individuals. METHODS Twenty two obese middle-aged men (49.32 ± 5.74 years; Body mass index: 30.88 ± 1.64 kg/m²) were randomly assigned to a combined training group (CTG, n = 12) or a control group (CG, n = 10). The CT consisted of aerobic (50-85% of VO2peak) and resistance (6-10 RM) training performed three times per week, 60 min per session for 24 weeks. The anthropometric measurements, cardiorespiratory test (VO2peak), maximal strength assessment (1RM) and plasma concentrations of total ghrelin and TNF-α were determined before (Pre) and after 24 weeks (Post) of the experimental period. RESULTS Decreases were found in body fat percentage (Δ% -19.8) and waist circumference (Δ% -2.8) for CTG at the Post moment as compared to the Pre moment. In addition, the CTG demonstrated increases for VO2peak (Δ% 13.4) and for 1-RM of bench press (Δ% 78.1), leg press (Δ% 22.3) and arm curl (Δ% 19.3) at the Post moment as compared to the Pre moment. However, total ghrelin levels remained unchanged for CTG and CG after the experimental period, while TNF-α levels increased for CG (p ≤ 0.05). CONCLUSION the CT protocol performed was not effective in repairing total ghrelin levels and was not correlated with changes in the TNF-α; however, the exercise training was able to improve body composition and functional capabilities and contained the worsening of systemic inflammation associated to obesity.

Resumo Fundamento: Insuficiência cardíaca direita apresenta grande morbimortalidade e pode ser causada por hipertensão arterial pulmonar. Um método diferenciado e inovador utilizado em avaliações histológicas é a dimensão fractal, que permite a caracterização de estruturas irregulares e complexas e pode quantificar alterações estruturais dos tecidos. Objetivo: Avaliar a utilização do método da dimensão fractal nos cardiomiócitos de ratos com hipertensão arterial pulmonar induzida por monocrotalina, associada com análise histológica e funcional. Métodos: Ratos Wistar machos foram divididos em 2 grupos: controle (C; n = 8) e hipertensão arterial pulmonar induzida por monocrotalina (M; n = 8). Após 5 semanas da indução da hipertensão arterial pulmonar pela monocrotalina, foi realizado ecocardiograma. Os animais foram eutanasiados, o coração dissecado e os ventrículos pesados para avaliação dos parâmetros anatômicos. Lâminas histológicas foram confeccionadas, coradas com hematoxilina/eosina para análise da dimensão fractal, realizada pelo método box-counting . Inicialmente foi testada a normalidade dos dados (teste Shapiro Wilk) e a comparação entre os grupos foi por meio do teste t de Student não pareado ou teste de Mann Whitney (p < 0,05). Resultados: Maiores valores da dimensão fractal foram observados no grupo M em comparação ao C (1,43 ± 0,06 vs. 1,37 ± 0,04; p < 0,05). O ecocardiograma apontou menores valores no grupo M para velocidade máxima pulmonar, tempo de aceleração pulmonar e tempo de ejeção, sugerindo piora funcional nesses animais, que também apresentaram hipertrofia cardíaca. Conclusão: As alterações observadas comprovam a disfunção cardíaca induzida pela hipertensão arterial pulmonar e apontam que a dimensão fractal é um método eficaz para avaliar alterações morfológicas cardíacas induzidas pela disfunção ventricular.

Abstract Background: Right-sided heart failure has high morbidity and mortality, and may be caused by pulmonary arterial hypertension. Fractal dimension is a differentiated and innovative method used in histological evaluations that allows the characterization of irregular and complex structures and the quantification of structural tissue changes. Objective: To assess the use of fractal dimension in cardiomyocytes of rats with monocrotaline-induced pulmonary arterial hypertension, in addition to providing histological and functional analysis. Methods: Male Wistar rats were divided into 2 groups: control (C; n = 8) and monocrotaline-induced pulmonary arterial hypertension (M; n = 8). Five weeks after pulmonary arterial hypertension induction with monocrotaline, echocardiography was performed and the animals were euthanized. The heart was dissected, the ventricles weighed to assess anatomical parameters, and histological slides were prepared and stained with hematoxylin/eosin for fractal dimension analysis, performed using box-counting method. Data normality was tested (Shapiro-Wilk test), and the groups were compared with non-paired Student t test or Mann Whitney test (p < 0.05). Results: Higher fractal dimension values were observed in group M as compared to group C (1.39 ± 0.05 vs. 1.37 ± 0.04; p < 0.05). Echocardiography showed lower pulmonary artery flow velocity, pulmonary acceleration time and ejection time values in group M, suggesting function worsening in those animals. Conclusion: The changes observed confirm pulmonary-arterial-hypertension-induced cardiac dysfunction, and point to fractal dimension as an effective method to evaluate cardiac morphological changes induced by ventricular dysfunction.

O objetivo do presente estudo foi investigar os efeitos de seis semanas de treinamento periodizado em natação (TPN) na capacidade aeróbia e peso corporal (PC) de ratos alimentados com dieta normal ou hipercalórica. 24 ratos Wistar (90 dias de idade) foram divididos em dois grupos: Normocalórico (NC, n = 12) e Hipercalórico (HC, n = 12). Os ratos foram alimentados com as respectivas dietas (NC e HC) por oito semanas e TPN por seis semanas. Antes (pré) e depois (pós) ao TPN os animais foram submetidos ao teste para a determinação da capacidade aeróbia (CA), usando o “Teste de Chassain”. Não se observou mudanças significativas na CA no grupo HC (pré = 5.59 ± 4.56% PC, post = 4.45 ± 1.66% PC), mas no grupo NC, houve o aumento significante (pré = 3.95 ± 2.42% PC e pós = 4.48 ± 1.18% PC) respectivamente

The main aim of the present study was to analyse the effects induced by six weeks of swimming periodized training (SPT) on the aerobic capacity (AC) and body weight (BW), on rats fed with either normal or hypercaloric diets. Twenty-four Wistar rats (90 days old) were divided in two groups: Normocaloric (NG, n = 12) and Hypercaloric (HG, n = 12). The rats were fed with respective diets (NG or HG) for eight weeks and then underwent SPT for six weeks. Before (pre) and after (post) the SPT, the animals were submitted to an AC determination, using a ”Chassain Test” . There was no significant changes to AC in the HG group (pre = 5.59 ± 4.56% BW vs. post = 4.45 ± 1.66% BW), but in the NG group it increased significantly (pre = 3.95 ± 2.42% BW vs. post = 4.48 ± 1.18% BW).

INTRODUÇÃO: A prática regular de exercícios físicos é considerada fundamental para prevenção e tratamento da Síndrome Metabólica, porém pouco se sabe sobre a forma ideal de treinamento. OBJETIVO: Verificar o efeito de 16 semanas de treinamento concorrente (TC) com frequência semanal e duração da sessão similar ao treinamento de força (TF) e treinamento aeróbio (TA) isolados sobre os componentes da síndrome metabólica (SM) de homens de meia-idade. MÉTODOS: Foram selecionados 42 homens clinicamente saudáveis distribuídos em quatro grupos: TA (n = 13), TF (n = 9), TC (n = 10) e grupo controle (GC, n = 10). Os treinamentos foram compostos por duas etapas (E1 e E2) com duração de oito semanas cada, e frequência de três sessões/semana (TF: dez exercícios com 3 x 8-10 RM; TA: 60 min. de caminhada ou corrida a 55-85% VO2pico; TC: seis exercícios com 3 x 8-10 RM, seguidos de 30 min. de caminhada ou corrida a 55-85% VO2pico). Foram avaliadas circunferência de cintura (CC), perfil lipídico, glicose, pressão arterial (PA) e força máxima e VO2pico. RESULTADOS: A CC reduziu para o TA (-1,70%; p = 0,023) e TC (-1,66%; p = 0,018) e o LDL para o TF (-25,03%; p = 0,047) e TC (29,74%; p = 0,011). O TC promoveu redução na PA sistólica (-7,83%; p = 0,029). A força máxima e VO2pico aumentaram para os três grupos de treinamento (p > 0,05). CONCLUSÃO: A realização do TC frequência semanal e duração das sessões similar ao TA e TF isolados é mais eficaz para a melhora de componentes da SM.

INTRODUCTION: The practice of regular physical exercise is considered critical to prevention and treatment of metabolic syndrome, but little is known about the ideal form of training. OBJECTIVE: To investigate the effect of 16 weeks of concurrent training (CT) with weekly frequency and duration of the session similar to strength training (ST) and endurance training (ET) isolates, in the components of metabolic syndrome (MS) of middle-age men. METHODS: Forty-two clinically healthy men were selected and divided into four groups: ET (n = 13), ST (n = 9), CT (n = 10) and control group (CG, n = 10). The training was composed of two steps (E1 and E2) with a duration of eight weeks each, and frequency of three sessions/week (ST: ten exercises with 3 x 8-10 RM; AT: 60 min. Walking or running at 55 -85% VO2peak, CT: six exercises with 3 x RM 8.10, followed by 30 min. walking or running at 55-85% VO2peak). We evaluated waist circumference (WC), lipid profile, glucose, blood pressure (BP), maximum force and VO2peak. RESULTS: The WC reduced to the AT (-1.70%, p = 0.023) and CT (-1.66%, p = 0.018) and LDL to the ST (-25.03%, P = 0.047) and CT (29.74%, p = 0.011). The CT promoted the reduction in systolic BP (-7.83%, P = 0.029). The maximum force and peak VO2 increased for the three training groups (p > 0.05). CONCLUSION: The performance of CT weekly frequency and duration of sessions similar to the ET and ST alone is more effective for the improvement of MS components.

INTRODUÇÃO: As alterações corporais provenientes da menopausa como a diminuição da massa magra (MM), aumento e redistribuição da gordura corporal e diminuição do gasto energético de repouso, colaboram para o aumento nas dimensões corporais e subsequente aumento da massa corporal total. Nesse sentido, os benefícios reconhecidos do treinamento com pesos (TP) não estão atrelados apenas ao aumento da força e hipertrofia muscular, mas também à composição corporal e, consequentemente, na taxa metabólica de repouso (RMR). OBJETIVO: Avaliar a resposta da RMR após 16 semanas de TP em mulheres na pós-menopausa. MÉTODOS: Participaram 28 voluntárias, subdivididas em dois grupos: treinamento (GT n = 17) e controle (GC n = 11). O programa de TP foi realizado em três sessões semanais, em dias alternados e com duração de aproximadamente 60 min/sessão, por 16 semanas. A intensidade da carga foi determinada por meio de zona alvo de repetições máximas (RM), com reajuste semanal de carga. O consumo de oxigênio (<img src="/img/revistas/rbme/v17n5/img01.jpg">O2) e da produção de gás carbônico (<img src="/img/revistas/rbme/v17n5/img01.jpg">CO2), por meio de calorimetria indireta de circuito aberto, foi utilizado para cálculo da RMR segundo equação de Weir (1949). ANÁLISE ESTATÍSTICA: Foi utilizado pacote estatístico Bioestat na versão 5.0, com nível de significância de p < 0,05. RESULTADOS: Houve aumento significante dos valores de MM e força muscular, somente no GT. Não foram encontradas diferenças significantes para os valores da RMR após a intervenção para ambos os grupos. CONCLUSÃO: O programa de TP de 16 semanas foi eficiente para promover alterações na composição corporal e força muscular de mulheres na pós-menopausa; entretanto, não houve alteração da RMR após a intervenção.

INTRODUCTION: The physical changes from menopause such as decrease in lean mass (LM), growth and redistribution of body fat and decrease in resting energy expenditure, contribute to the increase in body size and subsequent increase in total body mass. Accordingly, the recognized benefits of resistance training (RT) are not only linked to increased strength and muscle hypertrophy, but also to body composition and consequently to the resting metabolic rate (RMR). OBJECTIVE: To evaluate the RMR response after 16 weeks of RT in postmenopausal women. METHODS: 28 female volunteers subdivided into two groups participated in the study: training (TG n = 17) and control (CG n = 11). The RT program was conducted in three weekly sessions, on alternate days and lasted approximately 60 min/session during 16 weeks. Load intensity was determined by means of target area of maximum repetitions, with weekly load readjustment. The oxygen consumption (<img border=0 width=32 height=32 id="_x0000_i1040" src="../../../../img/revistas/rbme/v17n5/img01.jpg">O2) and carbon dioxide production (<img border=0 width=32 height=32 id="_x0000_i1039" src="../../../../img/revistas/rbme/v17n5/img01.jpg">CO2), using open circuit indirect calorimetry was used to calculate the RMR according to Weir equation (1949). STATISTICAL ANALYSIS: statistical package Bioestat, version 5.0, with a significance level of p <0.05 was used. RESULTS: There was significant increase of the LM values and muscle strength in TG only. No significant differences were found for the RMR values after intervention for both groups. CONCLUSION: The RT program of 16 weeks was effective in promoting changes in body composition and muscle strength in postmenopausal women; nevertheless, there was not change in RMR after intervention.

This paper describes the main activities regarding scientific dissemination in the field of Chemistry at Casa da Descoberta (CD) - a Scientific Dissemination Center of the Fluminense Federal University. It presents a brief history of CD and discusses the difficulties concerning the dissemination of Chemistry at Scientific Dissemination Centers. This work also approaches some activities developed throughout the years: experiments performed in relation to the visitors' daily life, training of monitors to act as mediators in the non-formal teaching of Chemistry, production of dissemination materials, elaboration of books, as well as activities that relate formal to non-formal education.