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Abstract This study evaluated the influence of a fluoride-modified titanium surface on osseointegration in rats with induced diabetes. One hundred and eighty rats were randomly allocated into 3 groups with 60 animals each: Control group (C): Animals without diabetes; Diabetes Group (D): Animals with uncontrolled induced diabetes; Controlled Diabetes Group (CD): Animals with diabetes induced controlled by the insulin administration. Diabetes was induced by streptozotocin injection. Each animal received 2 implants in the proximal tibial metaphysis, one with the machined surface (M) and the other one with a fluoride-modified titanium surface (F), after 4 weeks of induction of diabetes. The animals were submitted to euthanasia 2, 4, and 6 weeks after the implant placement (n = 20 animals/group). The osseointegration was evaluated by the implant removal torque test and the histometric analysis of the non-decalcified histological sections: 1) Contact bone/implant (%BIC); 2) Bone tissue area between implant threads (%BBT). Implants with F surface showed a higher removal torque than implants with surface M in all groups. There was no difference in %BIC between the groups regardless of the surface used. The F surface showed a tendency to present higher %BBT values for the 3 evaluation periods in the D group. The fluoride-modified implant surface has no impact on the %BIC and %BBT. However, the fluoride-modified implant surface increases the locking of the implants with the bone. The hyperglycemia was associated with lower removal torque values despite the surfaces of the implant used.

Resumo Este estudo avaliou a influência de uma superfície de titânio modificada com flúor na osseointegração em ratos com diabetes induzida. Cento e oitenta ratos foram distribuídos aleatoriamente em 3 grupos com 60 animais cada: Grupo controle (C): Animais sem diabetes; Grupo Diabetes (D): Animais com diabetes induzida descompensada; Grupo Diabetes Controlado (CD): Animais com diabetes induzido controlado pela administração de insulina. O diabetes foi induzido por injeção de estreptozotocina. Cada animal recebeu 2 implantes na metáfise proximal da tíbia, um com superfície usinada (M) e outro com superfície de titânio modificado com flúor (F), após 4 semanas de indução do diabetes. Os animais foram submetidos à eutanásia 2, 4 e 6 semanas após a colocação do implante (n = 20 animais/grupo). A osseointegração foi avaliada pelo teste de torque de remoção do implante e pela análise histométrica dos cortes histológicos não descalcificados: 1) Contato osso-implante (%BIC); 2) Área de tecido ósseo entre as roscas do implante (%BBT). Os implantes com superfície F apresentaram maior torque de remoção do que os implantes com superfície M em todos os grupos. Não houve diferença no %BIC entre os grupos independente da superfície utilizada. A superfície F mostrou tendência a apresentar maiores valores de %BBT para os 3 períodos de avaliação no grupo D. As superfícies de implantes modificadas com flúor não influenciaram nos dados de %BIC e %BBT. Entretanto, essas superfícies aumentaram o travamento dos implantes no tecido ósseo. A hiperglicemia foi associada a menores torques de remoção dos implantes independentemente do tipo de superfície de implante utilizada.

https://doi.org/10.1590/0103-6440202305439

Análise de particularidades da participação lusófona em uma Rede de Conhecimentos em Enfermagem
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Zanchetta, Margareth Santos

; Medeiros, Marcelo

; Carvalho, José Carlos Marques de

; Baixinho, Cristina Rosa Soares Lavareda

; Primo, Cândida Caniçali

; Chaves, Manuel Carlos Rodrigues Fernandes

; Gouveia, Márcia Teles de Oliveira

; Girardon-Perlini, Nara Marilene Oliveira

; Rocha, Cristianne Maria Famer

; Costa, Edwaldo

; Santos, Walterlânia Silva

; Pessoa, Vera Lúcia Mendes de Paula

Escola Anna Nery

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2023, Volume 27 elocation e20220194

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

Abstract Objective To describe the conceptual exercise of reflecting on the possibilities and particularities of the participation of Lusophone schools of nursing in the Nursing Knowledge Network. Method An analysis was conducted using information obtained from an environmental scan of institutional resources following the conceptual framework by Prug and Prusak on the knowledge networks. The learnings reported in the analysis are based on the collected information and reflections on the positive and negative aspects of participation, while proposing possible solutions for an action plan. Results There is interest in the internationalization of research and collaborative work both as institutional actions to support nursing research and potential benefits due to participation in the Network. The collaborative work has potential to increase the impact of research, expedite dissemination and use of results both in education and in clinical practice, broadening the horizons of Lusophone nursing science. Conclusion and Implications for practice Participation of these institutions in the Network offers numerous possibilities to demonstrate the originality, creativity and expertise of their teaching and research practice, encouraging the sharing of ideas and practices. The practice of scientific production in all its scenarios by educators and students can be improved through refined ways of thinking, creating, producing, and disseminating knowledge.

Resumen Objetivo Describir el ejercicio conceptual de reflexión de las posibilidades y particularidades de la participación de facultades de Enfermería de lengua portuguesa en la Red de Conocimientos de Enfermería. Método Análisis de datos obtenidos de un sondeo de recursos institucionales bajo el marco conceptual de Prug y Prusak sobre la red de conocimiento. El planteamiento de aspectos positivos y negativos del aprendizaje abarcó soluciones para elaborar un plan de acción. Resultados En las acciones institucionales de apoyo a la investigación en Enfermería y los beneficios aspirados con la participación en la Red, existe un interés por la internacionalización de la investigación y el trabajo colaborativo –que tiene como objetivo aumentar el impacto de la investigación, estimular la divulgación y el aprovechamiento de los resultados en la enseñanza y la clínica, con la ampliación de los horizontes de la Enfermería de instituciones de habla portuguesa. Conclusión e Implicaciones en la práctica La Red ofrece numerosas posibilidades para las instituciones participantes respecto a la demostración de originalidad, creatividad y experiencia en la práctica docente y de investigación, fomentando el intercambio de ideas y prácticas. La práctica de la producción científica por profesores y estudiantes puede verse mejorada por la reflexión, creación, producción y difusión de conocimientos.

Resumo Objetivo Descrever o exercício conceitual de reflexão sobre as possibilidades e particularidades da participação das Escolas de Enfermagem e Faculdades de Enfermagem lusófonas na Rede de Conhecimentos em Enfermagem. Método Análise das informações obtidas em um levantamento de recursos institucionais de acordo com o marco conceitual proposto por Prug e Prusak sobre rede de conhecimentos. A ponderação de aspectos positivos e negativos - analisando o aprendizado com as informações - levou em consideração as possíveis soluções para um plano de ação. Resultados Tanto nas ações institucionais para suportar a pesquisa em Enfermagem como nos benefícios almejados com a participação na Rede existe o interesse na internacionalização da pesquisa e no trabalho colaborativo. Com a ampliação dos horizontes da ciência da Enfermagem lusófona, este trabalho visa aumentar o impacto da pesquisa e agilizar a divulgação e a utilização dos resultados, tanto na educação como na clínica. Conclusão e Implicações para a prática A participação das referidas instituições oferece inúmeras possibilidades de demonstrar originalidade, criatividade e perícia de sua prática docente e de pesquisa, favorecendo o compartilhamento de ideias e práticas. A prática de produção científica, por docentes e discentes, pode ser aprimorada pelo refinamento de modos de pensar, criar, produzir e disseminar.

https://doi.org/10.1590/2177-9465-ean-2022-0194pt

Profilaxis para sangrado gastrointestinal en pacientes del servicio de medicina interna de un hospital universitario
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Diaztagle-Fernández, Juan José

; Sprockel-Díaz, John Jaime

; Mojica-Corzo, Ezequiel Masdeeiner

; Vásquez-Hoyos, Leonidas

; Cruz-Buitrago, Roberto Hernando

; Eslava-Orozco, David Felipe

; Hernández-Aguirre, Andrés Camilo

; Navarro-Noguera, Juan Carlos

; Chaves-Santiago, Walter Gabriel

Universidad y Salud

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dec 2022, Volume 24 N. 3 Pages 273 - 278

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Introducción: Los medicamentos antiulcerosos son utilizados frecuentemente en pacientes hospitalizados, sin embargo, a menudo este uso no está indicado. Objetivo: Describir la frecuencia de prescripción e indicación de medicamentos para prevenir el sangrado gastrointestinal en pacientes hospitalizados. Materiales y métodos: Estudio de corte trasversal, descriptivo, prospectivo del servicio de Medicina Interna de la Sociedad de Cirugía de Bogotá- Hospital de San José de Bogotá, Colombia. Se excluyeron pacientes con diagnóstico de sangrado gastrointestinal o antecedente de alergia a los medicamentos antiulcerosos. Se recolectaron datos demográficos, así como fármacos prescritos. Se determinó si la indicación del fármaco era adecuada y se identificó el tipo de error de prescripción. Resultados: Se incluyeron 179 pacientes, 102 (57%) mujeres. Promedio de edad de 61,3 años (±20,2). El principal diagnóstico de ingreso fue enfermedad infecciosa 76 (42,4%). Del total de pacientes, 165 (92,17%) recibieron medicamento para prevención del sangrado gastrointestinal. La indicación fue adecuada en 75 pacientes (41,89%). El error más frecuente fue el uso en pacientes de bajo riesgo de sangrado, 101 (97,1%). Conclusión: Un alto porcentaje de los pacientes recibió medicación para la prevención del sangrado gastrointestinal. En aproximadamente la mitad de estos no estaba indicada.

Abstract Introduction: Anti-ulcer medications are frequently used in hospitalized patients, yet their use is not usually indicated. Objective: To describe the frequency of prescription and indication of medications to prevent gastrointestinal bleeding in hospitalized patients. Materials and methods: A cross-sectional, descriptive, prospective study was carried out in the Internal Medicine service of the Surgery Society of Bogota-San Jose Hospital of Bogota (Colombia). Excluded patients were those with either a gastrointestinal bleeding diagnosis or a history of allergy to anti-ulcer medications. Demographic data and information regarding prescribed medications were collected. It was determined whether the medicine indication was adequate and the type of prescription error was identified. Results: 179 patients were included in the study, 57% (102) of which were women. The average age was 61.3 (±20.2) years old. Infectious disease was the main admission diagnosis (76; 42.4%). A 92.17% (165) of the total number of patients received medications to prevent gastrointestinal bleeding. This indication was adequate for 75 (41.89%) patients. The most frequent error was their use in bleeding low-risk patients (101; 97.1%). Conclusion: A high percentage of patients received medication to prevent gastrointestinal bleeding. However, in about half of these patients it was not indicated.

https://doi.org/10.22267/rus.222403.282 69 downloads

Recomendaciones en el abordaje del hematoma intracerebral espontáneo durante la internación
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Pigretti, Santiago G.

; Mirofsky, Matías

; García, Darío E.

; Issac, Cristian

; Valdez, Pascual

; Persi, Gabriel G.

; Mamani, Carlos E.

; Guyon, Jorgelina

; Álvarez, Héctor

; Montes, Mariana

; Daza Aramayo, José M.

; Iturrieta, Pablo

; Chaves, Hernán

; Sarmiento, Verónica

; Tumino, Leandro

; Domeniconi, Gustavo

; Castagna, Rosa

; Sabio, Rodrigo

; Videtta, Walter

; Ciarrocchi, Nicolás

; Lerman, Damián

; Dossi, Daiana E.

; Balian, Natalia R.

; Velasquez, Mariela A.

; Rufino Saravia, Gonzalo

; Alet, Matías J.

; Rodríguez Lucci, Federico

; Ciardi, Celina

; Pujol Lereis, Virginia

; Claverie, Santiago

; Casanova, Matías

; González, Leonardo

; Mónaco, Juan Manuel

; Cárdenas, Rolando E.

; Cirio, Juan José

; Arturi, Jessica

; Requejo, Flavio

; Plou, Pedro L.

; Orzuza, Gabriela

; Bonardo, Pablo

; Díaz, María Fernanda

; Payaslian, Silvio

; Andrade, María Gabriela

; Gomez Schneider, Maia M.

; Romano, Marina

; Colla Machado, Pedro

; Arroyo, José

; Arcondo, María Florencia

; Svampa, Silvana

; Armenteros, Cristhian

; Tejada Jacob, Virginia

; Zurrú, María Cristina

Medicina (Buenos Aires)

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nov 2022, Volume 82 Suppl. 4 Pages 1 - 56

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen El accidente cerebrovascular (ACV) constituye la principal causa de discapacidad de origen neuro- lógico en los adultos mayores a 40 años y la cuarta causa de muerte en Argentina. En los últimos diez años las publicaciones indexadas relacionadas al tratamiento del ACV isquémico fueron más numerosas que las de ACV hemorrágico. El objetivo de este material es proporcionar recomendaciones locales y actualiza- das del abordaje de pacientes con hematoma intraparenquimatoso espontáneo durante la internación. Para la redacción de este manuscrito se convocó a especialistas en esta enfermedad que conformaron grupos de trabajo. Se plantearon 10 tópicos centrales expresados como epidemiologia, atención inicial, imágenes, tratamiento de la presión arterial, reversión de antitrombóticos, indicación de cirugía, profilaxis anticonvulsivante, pronóstico, prevención de complicaciones y reinicio de antitrombóticos. De cada tópico se plantearon mediante preguntas PICO los interrogantes más frecuentes de la práctica diaria. Luego de una revisión sistemática de la literatura, se generaron recomendaciones evaluadas mediante sistema GRADE y consensuadas entre autores y pacientes.

Abstract Stroke is the leading cause of neurological disability in people over 40 years of age and the fourth leading cause of death in Argentina. In the last ten years, the indexed publications related to the treatment of ischemic stroke were more numerous than those of hemorrhagic stroke. The objective of this material is to provide local and updated recommendations for the management of patients with spontaneous intracere- bral hemorrhage during hospitalization. For the writing of this manuscript, diferent specialists were convened to form working groups. Ten central topics expressed as epidemiology, initial care, imaging, blood pressure treatment, reversal of antithrombotics, indication for surgery, seizure prophylaxis, prognosis, prevention of complications and resumption of antithrombotics were raised. For each topic, the most frequent questions of daily practice were raised through PICO questions. After a systematic review of the literature, recommendations were generated, evaluated using the GRADE system and agreed between authors and patients.

Guía de práctica clínica para el manejo de la neumonía adquirida en la comunidad
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Cortés, Jorge Alberto

; Cuervo-Maldonado, Sonia Isabel

; Nocua-Báez, Laura Cristina

; Valderrama, Martha Carolina

; Sánchez, Edgar Alberto

; Saavedra, Alfredo

; Torres, July Vianneth

; Forero, Diana Paola

; Álvarez-Moreno, Carlos Arturo

; Leal, Aura Lucía

; Pérez, Jairo Enrique

; Rodríguez, Iván Arturo

; Guevara, Fredy Orlando

; Saavedra, Carlos Humberto

; Vergara, Erika Paola

; Montúfar, Franco Eduardo

; Espinosa, Tatiana

; Chaves, Walter

; Carrizosa, Jorge Armando

; Meléndez, Sugeich Del Mar

; Espinosa, Carmelo José

; García, Felipe

; Guzmán, Ingrid Jany

; Cortés, Sergio Leonardo

; Díaz, Jorge Augusto

; González, Nathaly

Revista de la Facultad de Medicina

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jun 2022, Volume 70 N. 2 elocation e93814

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen La neumonía sigue siendo una de las principales causas de consulta y de hospitalización a la que, además de su un alto impacto en términos de morbilidad y mortalidad, se suma la actual problemática de resistencia a los antimicrobianos, por lo que establecer directrices que permitan su adecuado diagnóstico y tratamiento es de gran importancia para obtener mejores desenlaces clínicos y promover un uso racional de antibióticos en estos pacientes. La presente guía de práctica clínica (GPC) contiene recomendaciones basadas en la evidencia para el diagnóstico y tratamiento de la neumonía adquirida en la comunidad en adultos, las cuales fueron realizadas mediante el proceso de adaptación de GPC basadas en la evidencia para el contexto colombiano.

Abstract Pneumonia continues to be one of the main causes of consultation and hospitalization to which, besides its high impact on morbidity and mortality, the current problem of antimicrobial resistance is added; thus, establishing guidelines that allow its adequate diagnosis and treatment is of great importance to obtain better clinical outcomes and promote a rational use of antibiotics in these patients. This clinical practice guideline (CPG) contains evidence-based recommendations for the diagnosis and treatment of community-acquired pneumonia in adult population; these recommendations were made by means of the process of adaptation of evidence-based CPGs for the Colombian context.

https://doi.org/10.15446/revfacmed.v70n2.93814.

Biochemical profile of castrated and uncastrated male goats supplemented with vitamin E or not
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Pereira, Anderson Lopes

; Brito, Danilo Rodrigues Barros

; Cutrim Júnior, José Antônio Alves

; Castro, Lucimeire Amorim

; Silva, Igor Cassiano Saraiva

; Chaves, Daniel Praseres

; Silva Neto, Carlos Nunes da

Revista Brasileira de Saúde e Produção Animal

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2022, Volume 23 elocation e21472022

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivou-se avaliar os parâmetros bioquímicos de caprinos submetidos ou não a castração e recebendo ou não suplementação com vitamina E. Um total de 24 caprinos, machos não castrados (12 unidades experimentais) e machos castrados (12 unidades experimentais), com peso corporal médio de 17,6 kg ± 2,67 kg, foram distribuídos em delineamento inteiramente casualizado em arranjo fatorial 2 x 2, sendo duas condições animais (macho castrado e não castrado) e suplementação com vitamina E (com e sem suplementação), com seis repetições. Houve efeito dos tratamentos (P<0,05) ao longo do tempo para todas as variáveis estudadas. Houve efeito da suplementação vitamínica (P<0,05) para fósforo, ferro, proteína, glicose, aspartato aminotransferase (AST), alanina aminotransferase (ALP) e gama-glutamiltransferase (GGT). A suplementação vitamínica elevou os níveis de glicose, creatinina e GTT ao longo do tempo, e reduziu os níveis de fósforo, ferro, proteína, albumina, AST e ALP. Concluímos que a vitamina E influenciou nos parâmetros bioquímicos estudados, porém a castração não alterou o perfil bioquímico de caprinos, independentemente de estarem suplementados ou não com a vitamina E.

ABSTRACT The objective of this study was to evaluate the biochemical parameters of goats submitted to castration or not and receiving supplementation with vitamin E or not. A total of 24 goats, uncastrated (12 experimental units) and castrated males (12 experimental units), with average body weight weighing 17.6 kg ± 2.67 kg, were distributed in a completely randomized design in a 2 x 2 factorial arrangement, with two animal conditions (castrated and uncastrated male) and vitamin E supplementation (with and without supplementation), with six replications. There was an effect of treatments (P<0.05) over time for all studied variables. There was an effect of vitamin supplementation (P<0.05) for phosphorus, iron, protein, glucose, aspartate aminotransferase (AST), alanine aminotransferase (ALP) and gamma-glutamyltransferase (GGT). Vitamin supplementation increased glucose, creatinine and GTT levels over time, and reduced levels of phosphorus, iron, protein, albumin, AST and ALP. We conclude that vitamin E influenced the biochemical parameters studied, but castration did not change the biochemical profile of goats, regardless of whether they were supplemented with vitamin E or not.

https://doi.org/10.1590/s1519-994021472022

Brazilian Thoracic Association Consensus on Sleep-disordered Breathing
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Duarte, Ricardo Luiz de Menezes

; Togeiro, Sonia Maria Guimarães Pereira

; Palombini, Luciana de Oliveira

; Rizzatti, Fabíola Paula Galhardo

; Fagondes, Simone Chaves

; Magalhães-da-Silveira, Flavio José

; Cabral, Marília Montenegro

; Genta, Pedro Rodrigues

; Lorenzi-Filho, Geraldo

; Clímaco, Danielle Cristina Silva

; Drager, Luciano Ferreira

; Codeço, Vitor Martins

; Viegas, Carlos Alberto de Assis

; Rabahi, Marcelo Fouad

Jornal Brasileiro de Pneumologia

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2022, Volume 48 N. 4 elocation e20220106

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O sono é essencial para o adequado funcionamento de todos os indivíduos. Os distúrbios respiratórios do sono ocorrem em todas as faixas etárias, constituindo motivo frequente de consulta médica. O objetivo deste consenso foi atualizar os conhecimentos sobre os principais distúrbios respiratórios do sono tanto na população adulta quanto na pediátrica, com ênfase na apneia obstrutiva do sono. A apneia obstrutiva do sono é uma doença extremamente prevalente, porém frequentemente subdiagnosticada. Associa-se frequentemente a uma série de comorbidades, notadamente cardiovasculares, metabólicas e neurocognitivas, que impactam significativamente na qualidade de vida e na mortalidade. Por conta disso, o Departamento de Distúrbios Respiratórios do Sono da Sociedade Brasileira de Pneumologia e Tisiologia reuniu 14 especialistas com reconhecida e comprovada experiência em distúrbios respiratórios do sono para a elaboração deste documento.

ABSTRACT Sleep is essential for the proper functioning of all individuals. Sleep-disordered breathing can occur at any age and is a common reason for medical visits. The objective of this consensus is to update knowledge about the main causes of sleep-disordered breathing in adult and pediatric populations, with an emphasis on obstructive sleep apnea. Obstructive sleep apnea is an extremely prevalent but often underdiagnosed disease. It is often accompanied by comorbidities, notably cardiovascular, metabolic, and neurocognitive disorders, which have a significant impact on quality of life and mortality rates. Therefore, to create this consensus, the Sleep-Disordered Breathing Department of the Brazilian Thoracic Association brought together 14 experts with recognized, proven experience in sleep-disordered breathing.

https://doi.org/10.36416/1806-3756/e20220106

Brazilian guidelines for the treatment of outpatients with suspected or confirmed COVID-19. A joint guideline of the Brazilian Association of Emergency Medicine (ABRAMEDE), Brazilian Medical Association (AMB), Brazilian Society of Angiology and Vascular Surgery (SBACV), Brazilian Society of Geriatrics and Gerontology (SBGG), Brazilian Society of Infectious Diseases (SBI), Brazilian Society of Family and Community Medicine (SBFMC), and Brazilian Thoracic Society (SBPT)
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Falavigna, Maicon

; Belli, Karlyse Claudino

; Barbosa, Alexandre Naime

; Zavascki, Alexandre Prehn

; Nastri, Ana Catharina de Seixas Santos

; Santana, Christiane Machado

; Stein, Cinara

; Gräf, Débora Dalmas

; Cadegiani, Flavio Adsuara

; Guimarães, Hélio Penna

; Monteiro, José Tadeu

; Ferreira, Juliana Carvalho

; de Azevedo, Luciano Cesar Pontes

; Magri, Marcelo Mihailenko Chaves

; Sobreira, Marcone Lima

; Dias, Maria Beatriz Gandra de Souza

; de Oliveira, Maura Salaroli

; Corradi, Mirian de Freitas Dal Ben

; Rosa, Regis

; Heinzelmann, Ricardo Souza

; da Silva, Rosemeri Maurici

; Belfort Junior, Rubens

; Cimerman, Sergio

; Colpani, Verônica

; Veiga, Viviane Cordeiro

; de Carvalho, Carlos Roberto Ribeiro

Brazilian Journal of Infectious Diseases

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2022, Volume 26 N. 2 elocation 102347

Abstract: En | Text: En | PDF: En

ABSTRACT Background Several therapies have been used or proposed for the treatment of COVID-19, although their effectiveness and safety have not been properly evaluated. The purpose of this document is to provide recommendations to support decisions about the drug treatment of outpatients with COVID-19 in Brazil. Methods A panel consisting of experts from different clinical fields, representatives of the Brazilian Ministry of Health, and methodologists (37 members in total) was responsible for preparing these guidelines. A rapid guideline development method was used, based on the adoption and/or adaptation of recommendations from existing international guidelines combined with additional structured searches for primary studies and new recommendations whenever necessary (GRADE-ADOLOPMENT). The rating of quality of evidence and the drafting of recommendations followed the GRADE method. Results Ten technologies were evaluated, and 10 recommendations were prepared. Recommendations were made against the use of anticoagulants, azithromycin, budesonide, colchicine, corticosteroids, hydroxychloroquine/chloroquine alone or combined with azithromycin, ivermectin, nitazoxanide, and convalescent plasma. It was not possible to make a recommendation regarding the use of monoclonal antibodies in outpatients, as their benefit is uncertain and their cost is high, with limitations of availability and implementation. Conclusion To date, few therapies have demonstrated effectiveness in the treatment of outpatients with COVID-19. Recommendations are restricted to what should not be used, in order to provide the best treatment according to the principles of evidence-based medicine and to promote resource savings by aboiding ineffective treatments.

https://doi.org/10.1016/j.bjid.2022.102347

Aura de amor sobrenatural (de Apolonio de Tiana a Carlos Fuentes)
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Chaves, José Ricardo

Acta poética

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dec 2021, Volume 42 N. 2 Pages 107 - 127

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract: In this essay the comparative follow-up of the motive of the dis / encounter of lovers belonging to different ontological fields (life / death, wakefulness / sleep), expressed in fantastic figures such as empusas, ghosts and vampires is carried out. The starting point is a story of Apollonius of Tiana according to the text of Philostratus, which was recovered by Goethe in The Bride of Corinth, taken up by 19th Century authors such as Théophile Gautier and Amado Nervo, and reworked by Carlos Fuentes in the 20th Century, in his novel Aura, with the addition of an 18th Century Japanese author, Ueda Akinari, who wrote stories along these lines.

Resumen: En este ensayo se hace el seguimiento comparatista del motivo del des/encuentro de los amantes pertenecientes a ámbitos ontológicos distintos (vida/muerte, vigilia/sueño), expresado en figuras fantásticas como empusas, fantasmas y vampiras. El punto de partida es una historia de Apolonio de Tiana según el texto de Filóstrato, que fue recuperada por Goethe en La novia de Corinto, retomada por autores del siglo XIX como Théophile Gautier y Amado Nervo, y reelaborada por Carlos Fuentes en el siglo XX, en su novela Aura, con el añadido de un autor japonés del siglo XVIII, Ueda Akinari, que escribió historias en esa línea.

https://doi.org/10.19130/iifl.ap.2021.2.18125 301 downloads

10.

Primary health care nurses: attitudes towards the person with mental disorder
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Nóbrega, Maria do Perpétuo Socorro de Sousa

; Fernandes, Carla Sílvia Neves da Nova

; Zerbetto, Sonia Regina

; Sampaio, Francisco Miguel Correia

; Carvalho, José Carlos

; Chaves, Suellen Cristina da Silva

Revista Gaúcha de Enfermagem

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2021, Volume 42 elocation e20200088

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivo Identificar as atitudes dos enfermeiros que atuam na Atenção Primária à Saúde frente à pessoa com transtorno mental e as variáveis relacionados aos cuidados de saúde prestados. Metodologia Estudo descritivo, correlacional, com 250 enfermeiros de 69 Unidades Básica de Saúde do município de São Paulo. A coleta de dados ocorreu entre abril e agosto de 2019 por meio da escala “Opiniões acerca da Doença Mental”. Os dados foram analisados por meio do teste de KrusKal-Wallis, com nível de confiança de 95% e significância estatística de p<0,05. Resultados A média global da escala foi 197, que demonstra atitudes negativas especialmente nas dimensões de Autoritarismo (44,6), Restrição Social (42,0), e positiva na dimensão Benevolência (51,7). Conclusão Os enfermeiros apresentam, tendencialmente, perfil atitudinal estigmatizante. É necessária intervenção formativa e permanente para que seja possível reduzir o estigma e melhorar o cuidado de base comunitária preconizado nas diretrizes da Rede de Atenção Psicossocial.

ABSTRACT Objective To identify the attitudes of nurses working in Primary Health Care towards the person with mental disorder and the variables related to health care provided. Methodology Descriptive, correlational study with 250 nurses from 69 Basic Health Units in the city of São Paulo. Data collection took place between April and August 2019 using the “Opinions about Mental Illness” scale. The data were analyzed using the KrusKal-Wallis test, with a 95% confidence level and statistical significance of p <0.05. Results The global mean of the scale was 197, which shows negative attitudes especially in the dimensions of Authoritarianism (44.6), Social Restriction (42.0), and positive in the dimension of Benevolence (51.7). Conclusion Nurses tend to have a stigmatizing attitudinal profile. It is necessary formative and permanent intervention so that it is possible to reduce stigma and improve community-based care recommended in the guidelines of the Psychosocial Care Network.

RESUMEN Objetivo Identificar las actitudes de los enfermeros que trabajan en Atención Primaria de Salud frente a la persona con trastorno mental y las variables relacionadas con la atención médica brindada. Metodología Estudio descriptivo, correlacional con 250 enfermeras de 69 Unidades Básicas de Salud en la ciudad de São Paulo. La recopilación de datos tuvo lugar entre abril y agosto de 2019 utilizando la escala "Opiniones sobre enfermedades mentales". Los datos se analizaron mediante la prueba de KrusKal-Wallis, con un nivel de confianza del 95% y una significación estadística de p <0,05. Resultados El promedio global de la escala fue 197, lo que muestra actitudes negativas especialmente en las dimensiones de Autoritarismo (44.6), Restricción social (42.0), y positivas en la dimensión de Benevolencia (51.7). Conclusión Las enfermeras tienden a tener un perfil de actitud estigmatizante. La intervención formativa y permanente es necesaria para que sea posible reducir el estigma y mejorar la atención comunitaria recomendada en las pautas de la Red de Atención Psicosocial.

https://doi.org/10.1590/1983-1447.2021.20200088 300 downloads

11.

Identification of clusters of asthma control: A preliminary analysis of the Inspirers studies
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Jácome, Cristina

; Amaral, Rita

; Almeida, Rute

; Pereira, Ana Margarida

; Couto, Mariana

; Araújo, Luís

; Alves-Correia, Magna

; Pereira, Mariana

; Ferreira-Magalhães, Manuel

; Loureiro, Cláudia Chaves

; Catarata, Maria Joana

; Santos, Lília Maia

; Cabral, Sara

; Pereira, João

; Ramos, Bárbara

; Lopes, Cristina

; Mendes, Ana

; Lopes, Anabela

; Rodrigues, José Carlos Cidrais

; Oliveira, Georgeta

; Aguiar, Ana Paula

; Afonso, Ivete

; Carvalho, Joana

; Arrobas, Ana Maria

; Costa, José

; Valério, Margarida

; Pereira, Marta

; Almeida, Teresa

; Dias, Joana

; Bom, Ana Todo

; Azevedo, João

; Ribeiro, Carmelita

; Alves, Marta

; Pinto, Paula Leiria

; Neuparth, Nuno

; Neves, Ana Castro

; Palhinha, Ana

; Marques, João Gaspar

; Martins, Pedro

; Trincão, David Pina

; Todo-Bom, Filipa

; Santos, Maria Alvarenga

; Branco, Joana

; Costa, Alberto

; Neto, Armandina Silva

; Santalha, Marta

; Lozoya, Carlos

; Santos, Natacha

; Silva, Diana

; Vasconcelos, Maria João

; Barata, Luís Taborda

; Teixeira, Maria Fernanda

; Pinto, Diana

; Alves, Rodrigo Rodrigues

; Moreira, Ana Sofia

; Pinto, Cláudia Sofia

; Silva, Pedro Morais

; Alves, Carlos

; Câmara, Raquel

; Coelho, Didina

; Bordalo, Diana

; Carvalho, Fernanda

; Fernandes, Ricardo

; Ferreira, Rosário

; Oliveira, José Ferraz de

; Menezes, Fernando

; Gomes, Ricardo

; Calix, Maria José

; Marques, Ana

; Cardoso, João

; Emiliano, Madalena

; Gerardo, Rita

; Nunes, Carlos

; Ferreira, José Alberto

; Lopes, Inês

; Alves, Adelaide

; Fonseca, João Almeida

Revista Portuguesa de Imunoalergologia

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dec 2020, Volume 28 N. 4 Pages 231 - 240

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Objetivos: Identificar clusters de controlo da asma baseados no Teste de Controlo da Asma e Rinite Alérgica (CARAT) e comparar as características dos doentes nos diferentes clusters. Métodos: Adultos e adolescentes (≥13 anos) com asma persistente foram recrutados em 29 centros no contexto de 2 estudos observacionais do projeto INSPIRERS. Foram recolhidos dados relativos a características demográficas e clínicas, adesão ao inalador, crenças sobre a medicação, sintomas de ansiedade e depressão, qualidade de vida e controlo da asma (CARAT, >24 bom controlo). Foi efetuada uma análise hierárquica de clusters usando a pontuação total do CARAT (CARAT-T).Resultados: Foram analisados 410 doentes (68% adultos), com uma idade mediana (percentil 25-percentil 75) de 28 (16-46) anos. Foram identificados três clusters [média CARAT-T(min-max)]: cluster 1 [27(24-30)], cluster 2 [19(14-23)] e cluster 3 [10(2-13)]. Os doentes no cluster 1 (34%) apresentavam melhor controlo da asma, melhor qualidade de vida, maior adesão aos inaladores e usavam um único inalador. Os doentes nos clusters 2 (50%) e 3 (16%) tinham a asma não controlada, menor adesão aos inaladores, mais sintomas de ansiedade e depressão e mais de metade reportavam pelo menos uma exacerbação no último ano. Adicionalmente, os doentes no cluster 3 eram predominantemente mulheres, tinham mais consultas médicas não agendadas, apresentavam mais sintomas de ansiedade, percebiam uma maior necessidade dos inaladores, mas também uma maior preocupação associada ao seu uso. Não se verificaram diferenças na idade, índice de massa corporal, função pulmonar, hábitos tabágicos, hospitalizações ou tempo de seguimento pelo médico especialista. Conclusões: Um método não supervisionado baseado no CARAT-T, identificou 3 clusters de doentes com diferentes características clínicas. O cluster com melhor controlo apresenta um ponto de corte semelhante ao estabelecido no estudo de validação do CARAT. Este estudo sugere ainda a existência de um ponto de corte adicional para distinguir doença mais grave. Mais investigação é necessária para validar os clusters identificados

Aims: To identify distinct asthma control clusters based on Control of Allergic Rhinitis and Asthma Test (CARAT) and to compare patients’ characteristics among these clusters. Methods: Adults and adolescents (≥13 years) with persistent asthma were recruited at 29 Portuguese hospital outpatient clinics, in the context of two observational studies of the INSPIRERS project. Demographic and clinical characteristics, adherence to inhaled medication, beliefs about inhaled medication, anxiety and depression, quality of life, and asthma control (CARAT, >24 good control) were collected. Hierarchical cluster analysis was performed using CARAT total score (CARAT-T). Results: 410 patients (68% adults), with a median (percentile 25-percentile 75) age of 28 (16-46) years, were analysed. Three clusters were identified [mean CARAT-T (min-max)]: cluster 1 [27(24-30)], cluster 2 [19(14-23)] and cluster 3 [10(2-13)]. Patients in cluster 1 (34%) were characterised by better asthma control, better quality of life, higher inhaler adherence and use of a single inhaler. Patients in clusters 2 (50%) and 3 (16%) had uncontrolled asthma, lower inhaler adherence, more symptoms of anxiety and depression and more than half had at least one exacerbation in the previous year. Furthermore, patients in cluster 3 were predominantly female, had more unscheduled medical visits and more anxiety symptoms, perceived a higher necessity of their prescribed inhalers but also higher levels of concern about taking these inhalers. There were no differences in age, body mass index, lung function, smoking status, hospital admissions or specialist physician follow-up time among the three clusters. Conclusion: An unsupervised method based on CARAT-T, identified 3 clusters of patients with distinct, clinically meaningful characteristics. The cluster with better asthma control had a cut-off similar to the established in the validation study of CARAT and an additional cut-off seems to distinguish more severe disease. Further research is necessary to validate the asthma control clusters identified.

https://doi.org/10.32932/rpia.2020.12.046 633 downloads

12.

Enfermeiros e escolas de enfermagem nos anuários da Universidade de Coimbra, de 1866 a 1956
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Queirós, Paulo Joaquim Pina

; Filho, Antonio José de Almeida

; Gómez-Cantarino, Sagrario

; Santos, Tânia Cristina Franco

; Peres, Maria Angélica de Almeida

; Chaves, Manuel Carlos Rodrigues Fernandes

; Espina-Jerez, Blanca

Revista de Enfermagem Referência

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oct 2020, Volume serV N. 4 Pages e20061 - e20061

Abstract: Es Pt En | Text: Es Pt En | PDF: Es | PDF: Pt | PDF: En

Contexto: El final del siglo XIX y el comienzo del siglo XX es un período de profundas transformaciones en las instituciones de asistencia y en sus profesionales. Objetivo: Conocer este período de la historia de la enfermería en Portugal. Analizar los anuarios de la Universidad de Coímbra, considerándolos como una fuente primaria. Metodología: Análisis descriptivo histórico de 73 anuarios, con estudio de las fuentes y construcción de síntesis descriptivas e interpretativas. Resultados: Comprobamos la concentración de material de los años comprendidos entre 1896 y 1927. El análisis resumió 4 temas: 1) nombres y funciones de los enfermeros; 2) los enfermeros en el decreto de reforma de los Hospitales Universitarios de Coímbra en 1911, el equipo y los sueldos en 1915-16; 3) los enfermeros ecuestres y militares en 1915-16 y 1917-18; 4) la escuela de enfermería de 1919-20 a 1926-27 y los profesores universitarios. Conclusión: Encontramos 104 nombres de enfermeros, con funciones definidas, considerados personal auxiliar y no personal clínico. El enfermero jefe aparece destacado. Aparece la escuela de enfermería de los hospitales universitarios, con la identificación de los profesores universitarios a cargo.

Contexto: O final do século XIX e o início do século XX é um período de profundas transformações nas instituições de assistência e nos seus profissionais. Objetivo: Conhecer este período da história da enfermagem em Portugal. Analisar os anuários da Universidade de Coimbra, considerando-os como fonte primária. Metodologia: Análise descritiva histórica de 73 anuários, com levantamento de fontes e construção de síntese descritiva e interpretativa. Resultados: Verificámos a concentração de material nos anos 1896 a 1927. A análise, sintetizou 4 tópicos: 1) nomes e funções dos enfermeiros; 2) os enfermeiros, no decreto de reforma dos Hospitais da Universidade de Coimbra, em 1911, o quadro e os vencimentos em 1915-16; 3) enfermeiros hípicos e militares em 1915-16 e 1917-18; 4) a escola de enfermagem de 1919-20 a 1926-27 e os professores universitários. Conclusão: Encontrámos 104 nomes de enfermeiros, com funções definidas, considerados pessoal auxiliar e não pessoal clínico. O enfermeiro chefe surge com destaque. Aparece a escola de enfermagem dos hospitais da universidade, com a identificação dos professores universitários regentes.

Background: The end of the 19th century and the beginning of the 20th century combine a period of profound transformations in care institutions and their professionals. Objective: To know this period of nursing history in Portugal, analyze the yearbooks of the University of Coimbra, considering them as the primary source. Methodology: Descriptive historical analysis of 73 yearbooks, with a survey of sources and construction of descriptive and interpretative synthesis. Results: The available material was centered on the years 1896 to 1927. The analysis synthesized 4 topics: 1) names and functions of nurses; 2) nurses, in the decree of the reform of the Hospitals of the University of Coimbra, in 1911, the staff and salaries in 1915-16; 3) equine veterinary nurses and military nurses in 1915-16 and 1917-18; 4) the nursing school from 1919-20 to 1926-27 and university professors. Conclusion: We found 104 names with defined functions, considered as auxiliary staff and non-clinical personnel. The head nurse comes out prominently. The nursing school of the university hospitals appears, with the identification of the university head teachers.

https://doi.org/10.12707/RV20061 271 downloads

13.

Antibacterial Activity of 2-Amino-1,4-naphthoquinone Derivatives against Gram-Positive and Gram-Negative Bacterial Strains and Their Interaction with Human Serum Albumin
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Silva, Carla C. da

; Chaves, Otávio A.

; Paiva, Rojane O.

; Costa, Gisela L. da

; Netto-Ferreira, José Carlos

; Echevarria, Aurea

Journal of the Brazilian Chemical Society

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sep 2020, Volume 31 N. 9 Pages 1838 - 1851

Abstract: En | Text: En | PDF: En

A series of 2-amino-1,4-naphthoquinone derivatives (NQA-NQF) was synthesized by alternative methods (ultrasonication and microwave irradiation), with yields ranging from 40 to 71%, and without the need of further recrystallization. Each compound was evaluated against four Gram-positive (Bacillus subtilis, Enterococcus faecalis, Staphylococcus aureus and Bacillus cereus) and five Gram-negative (Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae positive β-lactamase) bacteria strains. The NQF was the most active amino-naphthoquinone derivative with minimum inhibitory concentration (MIC) of 31.2 µg mL-1 against K. pneumoniae positive β-lactamase (a common intestinal bacteria which can cause life-threatening infections). On the other hand, NQA and NQC showed good activity as a potential antibiotic for the bacteria strains assayed, except for K. pneumoniae. In addition, the affinity of these three most active compounds (NQA, NQC, and NQF) for human serum albumin (HSA) was evaluated employing multiple spectroscopic techniques (steady-state, time-resolved, and synchronous fluorescence, as well as circular dichroism), combined with theoretical calculations (molecular docking). The interaction HSA:2-amino-1,4-naphthoquinones occurs spontaneously and moderately inside the subdomain IIA (Sudlow’s site I) via hydrogen bonding and van der Waals forces.

https://doi.org/10.21577/0103-5053.20200070 398 downloads

14.

Occurrence of Bartonella genotypes in bats and associated Streblidae flies from Maranhão state, northeastern Brazil
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Braga, Maria do Socorro Costa Oliveira

; Gonçalves, Luiz Ricardo

; Silva, Thiago Merighi Vieira da

; Costa, Francisco Borges

; Pereira, José Gomes

; Santos, Larissa Sarmento dos

; Carvalho Neta, Alcina Vieira de

; Arruda, Roberto Carlos Negreiros de

; Mesquita, Eric Takashi Kamakura de Carvalho

; Chaves, Daniel Prazeres

; Melo, Ferdinan Almeida

; Lopes, Jady Lima

; Martins, Rayra Tayla Barbosa

; Lima, Mauricio Souza

; Amaral, Renan Bressianini do

; Machado, Rosangela Zacarias

; André, Marcos Rogério

Revista Brasileira de Parasitologia Veterinária

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2020, Volume 29 N. 4 elocation e014420

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Bartonella é um gênero de bactérias zoonóticas emergentes associadas principalmente a eritrócitos e células endoteliais de mamíferos. Morcegos são reservatórios naturais para uma variedade de patógenos importantes que afetam a saúde humana e animal. Além disso, estudos recentes destacaram o papel dos morcegos e de moscas associadas a morcegos na manutenção de Bartonella. No presente estudo, nenhuma das 29 amostras de DNA obtidas a partir do sangue de cinco espécies de morcegos amostrados na ilha de São Luís, estado do Maranhão, Nordeste do Brasil, foi positiva para Bartonella nos ensaios de qPCR direcionados ao gene nuoG. Por outro lado, três das 15 (20%) amostras de DNA de moscas da família Streblidae foram positivas para Bartonella. Os resultados do BLASTn mostraram que as sequências dos genes gltA e rpoB compartilharam identidade, variando de 97,2% a 100%, com as sequências de Bartonella amplificadas em morcegos ou moscas amostrados na Costa Rica ou Brasil. Tais resultados corroboraram as análises filogenéticas realizadas por Inferência Bayesiana. O presente estudo mostrou a ocorrência de Bartonella em moscas de morcegos, auxiliando a esclarecer a distribuição dos genótipos de Bartonella relacionadas a moscas Streblidae na América do Sul.

Abstract Bartonella is a genus of emerging zoonotic bacteria that are mainly associated with mammalian erythrocytes and endothelial cells. Bats are natural reservoirs for a variety of important pathogens that impact human and animal health. Recent reports have highlighted the role of bats and bat flies in the maintenance of Bartonella. Here, we showed that none of the 29 bat DNA blood samples obtained from five bat species in São Luís Island, state of Maranhão, northeastern Brazil, were positive for Bartonella in qPCR assays targeting nuoG. On the other hand, three out of 15 DNA samples (20%) from flies in the family Streblidae were positive for Bartonella. The BLASTn results showed that the gltA and rpoB sequences shared identities ranging from 97.2% to 100%, with Bartonella sequences amplified from bats or bat flies from Costa Rica and Brazil. These findings were supported by phylogenetic analyses based on Bayesian inferences. The present study showed that Bartonella genotypes are present in bat flies, thus shedding some light on the distribution of bat fly-related Bartonella genotypes in South America.

https://doi.org/10.1590/s1984-29612020088 712 downloads

15.

A century of wheat breeding in Brazil: the origin and inheritance of the Lr34 locus in wheat varieties released from 1922 to 2016
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Chaves, Márcia Soares

; Silva, Gerarda Beatriz Pinto da

; Caierão, Eduardo

; Federizzi, Luiz Carlos

; Martinelli, José Antônio

Crop Breeding and Applied Biotechnology

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2020, Volume 20 N. 2 elocation e27952027

Abstract: En | Text: En | PDF: En

Abstract Wheat breeding in Brazil began in 1919. A cross between the varieties Fronteira and Mentana gave rise to Frontana, the most popular ever released, being recommended for more than 40 years. Frontana played an important role as a source of resistance to leaf and stripe rust as well as resistance to pre-harvest sprouting. Possessing an early maturity cycle, it contributed to change the predominant varietal pattern at that time. The resistance gene Lr34 was first described in Frontana. The gene confers durable adult plant resistance to leaf rust and other biotrophic fungi. Because of its durability, stability across environments, haplotype diversity and wide geographical distribution, Lr34 is probably the most important single resistance gene in wheat. We evaluated 453 wheat varieties that have been released or recommended for cultivation in Brazil from 1922 to 2016 using KASPar markers to detect those varieties carrying the diagnostic mutations corresponding to the presence of the Lr34 resistance allele.

https://doi.org/10.1590/1984-70332020v20n2a23 573 downloads

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