Results: 10
#1
au:CORREA, B. O.
Filters
Order by
Page
of 1
Next
1.
Amazonian soil fungi are efficient degraders of glyphosate herbicide; novel isolates of Penicillium, Aspergillus, and Trichoderma
Facebook Twitter
Facebook Twitter
- Other social networks
- Google+
- StambleUpon
- CiteULike
- Mendeley
- Other networks
- Metrics
Correa, L. O.
; Bezerra, A. F. M.
; Honorato, L. R. S.
; Cortez, A. C. A.
; Souza, J. V. B.
; Souza, E. S.
.
Resumo Resíduos de agrotóxicos que contaminam o meio ambiente circulam no ciclo hidrológico, podendo se acumular na cadeia alimentar e causar problemas tanto à saúde ambiental quanto humana. Por sua vez, microrganismos são bem conhecidos por sua versatilidade metabólica e capacidade de degradar substâncias quimicamente estáveis, incluindo xenobióticos recalcitrantes. O estudo atual se concentrou na bioprospecção nos solos da floresta amazônica para encontrar novas linhagens de fungos capazes de degradar com eficiência o herbicida onipresente na agricultura e no meio ambiente, o glifosato. Entre os 50 fungos isolados (usando meio de cultura suplementado com glifosato como única fonte de carbono), a maioria eram isolados do gênero Penicillium (60%) e os outros eram isolados de Aspergillus e Trichoderma (26 e 8%, respectivamente). Todos os 50 isolados de fungos foram capazes de usar glifosato como fonte de fósforo. Oito desses isolados cresceram melhor em meio suplementado com glifosato do que em meio Czapek Dox regular. LC-MS revelou que a degradação do glifosato por Penicillium 4A21 resultou nos metabólitos sarcosina e ácido aminometilfosfônico.
Abstract Pesticide residues that contaminate the environment circulate within the hydrological cycle can accumulate within the food chain and cause problems to both environmental and human health. Microbes, however, are well known for their metabolic versatility and the ability to degrade chemically stable substances, including recalcitrant xenobiotics. The current study focused on bio-prospecting within Amazonian rainforest soils to find novel strains fungi capable of efficiently degrading the agriculturally and environmentally ubiquitous herbicide, glyphosate. Of 50 fungal strains isolated (using culture media supplemented with glyphosate as the sole carbon-substrate), the majority were Penicillium strains (60%) and the others were Aspergillus and Trichoderma strains (26 and 8%, respectively). All 50 fungal isolates could use glyphosate as a phosphorous source. Eight of these isolates grew better on glyphosate-supplemented media than on regular Czapek Dox medium. LC-MS revealed that glyphosate degradation by Penicillium 4A21 resulted in sarcosine and aminomethylphosphonic acid.
https://doi.org/10.1590/1519-6984.242830
821 downloads
2.
Effects of Moringa oleifera and Brosimum alicastrum partial feed substitution in intramuscular fat and adipose tissues and on the expression of lipogenic genes of Mexican hairless pigs
Facebook Twitter
Facebook Twitter
- Other social networks
- Google+
- StambleUpon
- CiteULike
- Mendeley
- Other networks
- Metrics
Dzib Cauich, Dany A.
; Sierra Vásquez, Ángel C.
; Lemus Flores, Clemente
; Bugarín Prado, Job O.
; Grageola Núñez, Fernando
; Segura Correa, José C.
; Moo Huchin, Víctor M.
.
ABSTRACT The present study evaluated the effects of the inclusión of ground Moringa oleifera and Brosimum alicastrum leaf meal in the diet of Mexican hairless pigs (MHP) on the amount of intramuscular fat, subcutaneous fat, leg muscle (Biceps femoris) fat, loin muscle (Longissimus dorsi) fat, leg and back fat, and the expression of lipid metabolism genes. Hairless pigs are reared in the Mexican tropics and are characterised by their body and intramuscular fat accumulation. Eighteen male pigs fed for 82 d were randomly allotted to three experimental isoenergetic and isoproteic diets, where M. oleifera or B. alicastrum (six pigs per diet) replaced wheat bran. The diets used were a control diet, a diet with 10% M. oleifera leaf meal, and a diet with 10% ground B. alicastrum leaf meal. The M. oleifera diet decreased (P<0.05) the fat ratio in the Longissimus dorsi muscles, back fat, rib fat, total carcass fat, and the carcass fat: meat ratio. The B. alicastrum diet only decreased fat in the Biceps femoris muscle, back fat, and rib fat. Moringa oleifera and B. alicastrum diets also promoted the overexpression of mRNA from the stearoyl-CoA desaturase (SCD), fatty acid synthase (FASN), acetyl-CoA carboxylase alpha (ACACA), sterol regulatory element-binding protein 1 (SREBP1) and acyl carrier protein (ACP) lipogenic genes in the Biceps femoris muscle and leg fat (P<0.001). In addition, lower ACACA and SREBP1 mRNA expression in the Longissimus dorsi muscle and back fat (P<0.001) were related to the lower amount of fat in pigs fed M. oleifera and B. alicastrum. The inclusion of Moringa oleifera and Brosimum alicastrum meals 10% in the diet of the pig MHP reduces fat, this is an important finding because fat is abundant in this type of pig.
98 downloads
3.
Persistent symptoms and decreased health-related quality of life after symptomatic pediatric COVID-19: A prospective study in a Latin American tertiary hospital
Facebook Twitter
Facebook Twitter
- Other social networks
- Google+
- StambleUpon
- CiteULike
- Mendeley
- Other networks
- Metrics
Fink, Thais T.
; Marques, Heloisa H.S.
; Gualano, Bruno
; Lindoso, Livia
; Bain, Vera
; Astley, Camilla
; Martins, Fernanda
; Matheus, Denise
; Matsuo, Olivia M.
; Suguita, Priscila
; Trindade, Vitor
; Paula, Camila S.Y.
; Farhat, Sylvia C.L.
; Palmeira, Patricia
; Leal, Gabriela N.
; Suzuki, Lisa
; Odone Filho, Vicente
; Carneiro-Sampaio, Magda
; Duarte, Alberto José S.
; Antonangelo, Leila
; Batisttella, Linamara R.
; Polanczyk, Guilherme V.
; Pereira, Rosa Maria R.
; Carvalho, Carlos Roberto R.
; Buchpiguel, Carlos A.
; Latronico, Ana Claudia
; Seelaender, Marilia
; Silva, Clovis Artur
; Pereira, Maria Fernanda B.
; Sallum, Adriana M. E.
; Brentani, Alexandra V. M.
; Neto, Álvaro José S.
; Ihara, Amanda
; Santos, Andrea R.
; Canton, Ana Pinheiro M.
; Watanabe, Andreia
; Santos, Angélica C. dos
; Pastorino, Antonio C.
; Franco, Bernadette D. G. M.
; Caruzo, Bruna
; Ceneviva, Carina
; Martins, Carolina C. M. F.
; Prado, Danilo
; Abellan, Deipara M.
; Benatti, Fabiana B.
; Smaria, Fabiana
; Gonçalves, Fernanda T.
; Penteado, Fernando D.
; Castro, Gabriela S. F. de
; Gonçalves, Guilherme S.
; Roschel, Hamilton
; Disi, Ilana R.
; Marques, Isabela G.
; Castro, Inar A.
; Buscatti, Izabel M.
; Faiad, Jaline Z.
; Fiamoncini, Jarlei
; Rodrigues, Joaquim C.
; Carneiro, Jorge D. A.
; Paz, Jose A.
; Ferreira, Juliana C.
; Ferreira, Juliana C. O.
; Silva, Katia R.
; Bastos, Karina L. M.
; Kozu, Katia
; Cristofani, Lilian M.
; Souza, Lucas V. B.
; Campos, Lucia M. A.
; Silva Filho, Luiz Vicente R. F.
; Sapienza, Marcelo T.
; Lima, Marcos S.
; Garanito, Marlene P.
; Santos, Márcia F. A.
; Dorna, Mayra B.
; Aikawa, Nadia E.
; Litvinov, Nadia
; Sakita, Neusa K.
; Gaiolla, Paula V. V.
; Pasqualucci, Paula
; Toma, Ricardo K.
; Correa-Silva, Simone
; Sieczkowska, Sofia M.
; Imamura, Marta
; Forsait, Silvana
; Santos, Vera A.
; Zheng, Yingying
.
OBJECTIVES: To prospectively evaluate demographic, anthropometric and health-related quality of life (HRQoL) in pediatric patients with laboratory-confirmed coronavirus disease 2019 (COVID-19) METHODS: This was a longitudinal observational study of surviving pediatric post-COVID-19 patients (n=53) and pediatric subjects without laboratory-confirmed COVID-19 included as controls (n=52) was performed. RESULTS: The median duration between COVID-19 diagnosis (n=53) and follow-up was 4.4 months (0.8-10.7). Twenty-three of 53 (43%) patients reported at least one persistent symptom at the longitudinal follow-up visit and 12/53 (23%) had long COVID-19, with at least one symptom lasting for >12 weeks. The most frequently reported symptoms at the longitudinal follow-up visit were headache (19%), severe recurrent headache (9%), tiredness (9%), dyspnea (8%), and concentration difficulty (4%). At the longitudinal follow-up visit, the frequencies of anemia (11% versus 0%, p=0.030), lymphopenia (42% versus 18%, p=0.020), C-reactive protein level of >30 mg/L (35% versus 0%, p=0.0001), and D-dimer level of >1000 ng/mL (43% versus 6%, p=0.0004) significantly reduced compared with baseline values. Chest X-ray abnormalities (11% versus 2%, p=0.178) and cardiac alterations on echocardiogram (33% versus 22%, p=0.462) were similar at both visits. Comparison of characteristic data between patients with COVID-19 at the longitudinal follow-up visit and controls showed similar age (p=0.962), proportion of male sex (p=0.907), ethnicity (p=0.566), family minimum monthly wage (p=0.664), body mass index (p=0.601), and pediatric pre-existing chronic conditions (p=1.000). The Pediatric Quality of Live Inventory 4.0 scores, median physical score (69 [0-100] versus 81 [34-100], p=0.012), and school score (60 [15-100] versus 70 [15-95], p=0.028) were significantly lower in pediatric patients with COVID-19 at the longitudinal follow-up visit than in controls. CONCLUSIONS: Pediatric patients with COVID-19 showed a longitudinal impact on HRQoL parameters, particularly in physical/school domains, reinforcing the need for a prospective multidisciplinary approach for these patients. These data highlight the importance of closer monitoring of children and adolescents by the clinical team after COVID-19.
4.
Enzootic calcinosis in sheep in Uruguay: a brief review and report of two outbreaks
Facebook Twitter
Facebook Twitter
- Other social networks
- Google+
- StambleUpon
- CiteULike
- Mendeley
- Other networks
- Metrics
Machado, Mizael
; Schild, Carlos O.
; Preliasco, Marcela
; Balserini, Aldana
; Medeiros, Rosane M.T.
; Barros, Severo S.
; Riet-Correa, Franklin
.
RESUMO: Este trabalho faz uma breve revisão da calcinose enzoótica em ovinos e descreve dois surtos de intoxicação por Nierembergia rivularis em ovinos no Uruguai. Os surtos ocorreram em propriedades localizadas em uma ilha (Surto A), e nas margens (Surto B) do lago do Rincón del Bonete. Foram afetados ovinos de todas as idades, exceto cordeiros lactentes. Os primeiros sinais clínicos ocorreram no início de outubro e as mortes de dezembro a fevereiro. Morbidade de 10% foi observada nos Surtos A e B. A mortalidade foi de 7,2% e 2,8% nos Surtos A e B, respectivamente. Os sinais clínicos incluíram perda de peso, abdômen retraído, marcha rígida e cifose. Foram necropsiados um animal de cada rebanho. Observou-se mineralização arterial e pulmonar, nefrocalcinose e osteopetrose no exame macroscópico e histológico dos dois ovinos. Hiperplasia e carcinoma de células C da tireoide foram observados no ovino A. O ovino B apresentou hiperplasia de células C da tireoide e atrofia das células principais da paratireoide. As paratireoides do ovino A não foram examinadas. O diagnóstico diferencial da calcinose enzoótica no Sul da América do Sul deve considerar quatro plantas calcinogênicas da família Solanaceae: Solanum glaucophyllum, Solanum stuckertii, Nierembergia veitchii e Nierembergia rivularis.
ABSTRACT: This study aimed to do a brief review of enzootic calcinosis in sheep and to report two outbreaks of Nierembergia rivularis poisoning in sheep in Uruguay. The outbreaks occurred in farms located on an island (Outbreak A) and on the border (Outbreak B) of the Rincón del Bonete lake. Sheep of all ages were affected, with the exception of suckling lambs. The first clinical signs occurred in early October, and deaths occurred from December to February. Outbreaks A and B had morbidity of 10%, and the mortality was 7.2% and 2.8% in Outbreaks A and B, respectively. The clinical signs included weight loss, retracted abdomen, stiff gait, and kyphosis. An autopsy was performed on one sheep from each outbreak. Pulmonary and arterial calcification, nephrocalcinosis, and osteopetrosis were observed in gross and microscopic examination in both sheep. Thyroid C-cell hyperplasia and carcinoma was observed in sheep A. Sheep B showed thyroid C-cell hyperplasia and parathyroid chief cell atrophy. The parathyroid was not examined in the sheep from Outbreak A. The differential diagnosis of enzootic calcinosis in southern South America should consider four toxic plants in the Solanaceae family: Solanum glaucophyllum, Solanum stuckertii, Nierembergia veitchii, and Nierembergia rivularis.
https://doi.org/10.1590/1678-5150-pvb-6766
447 downloads
5.
Combined pituitary hormone deficiency caused by PROP1 mutations: update 20 years post-discovery
Facebook Twitter
Facebook Twitter
- Other social networks
- Google+
- StambleUpon
- CiteULike
- Mendeley
- Other networks
- Metrics
Correa, Fernanda A.
; Nakaguma, Marilena
; Madeira, João L. O.
; Nishi, Mirian Y.
; Abrão, Milena G.
; Jorge, Alexander A. L.
; Carvalho, Luciani R.
; Arnhold, Ivo J. P.
; Mendonça, Berenice B.
.
ABSTRACT The first description of patients with combined pituitary hormone deficiencies (CPHD) caused by PROP1 mutations was made 20 years ago. Here we updated the clinical and genetic characteristics of patients with PROP1 mutations and summarized the phenotypes of 14 patients with 7 different pathogenic PROP1 mutations followed at the Hospital das Clínicas of the University of Sao Paulo. In addition to deficiencies in GH, TSH, PRL and gonadotropins some patients develop late ACTH deficiency. Therefore, patients with PROP1 mutations require permanent surveillance. On magnetic resonance imaging, the pituitary stalk is normal, and the posterior lobe is in the normal position. The anterior lobe in patients with PROP1 mutations is usually hypoplastic but may be normal or even enlarged. Bi-allelic PROP1 mutations are currently the most frequently recognized genetic cause of CPHD worldwide. PROP1 defects occur more frequently among offspring of consanguineous parents and familial cases, but they also occur in sporadic cases, especially in countries in which the prevalence of PROP1 mutations is relatively high. We classified all reported PROP1 variants described to date according to the American College of Medical Genetics and Genomics and the Association for Molecular Pathology (ACMG-AMP) guidelines: 29 were pathogenic, 2 were likely pathogenic, and 2 were of unknown significance. An expansion of the phenotype of patients with PROP1 mutations was observed since the first description 20 years ago: variable anterior pituitary size, different pathogenic mutations, and late development of ACTH deficiency. PROP1 mutations are the most common cause of autosomal recessive CPHD with a topic posterior pituitary lobe. Arch Endocrinol Metab. 2019;63(2):167-74
https://doi.org/10.20945/2359-3997000000139
1874 downloads
6.
Apego a las guías de calidad en estudios de Colangiopancreatografía retrógrada endoscópica (CPRE) recomendados por la Asociación Americana de Endoscopia Gastrointestinal en un Hospital de Enseñanza, de Alto Volumen (Tercer Nivel)
Facebook Twitter
Facebook Twitter
- Other social networks
- Google+
- StambleUpon
- CiteULike
- Mendeley
- Other networks
- Metrics
Fernández-Enríquez, Enrique Raúl
; Topete-González, L.A.
; Bentancourt-Ferreyra, J.J.
; Valdivia-Correa, B.
; Rodríguez-Parra, A.F.
; Delano-Alonso, R.
; Valenzuela-Salazar, C.
; Bada-Yllan, O.
; Herrera-Esquivel, J.J
; Moreno-Portillo, M.
.
Abstract Introduction: Endoscopic retrograde cholangiopancreatography (ERCP) is one of the most technically demanding and high-risk procedures performed by gastrointestinal endoscopists. Gastroenterology associations have developed guidelines or position statements on various aspects of quality and safety indicators in ERCP. Objective: To know the frequency of adherence to quality indicators in studies of ERCP recommended by the American Gastrointestinal Endoscopy Association in the Gastrointestinal Endoscopy Service, Division of General Surgery of the “Manuel Gea González General Hospital”. Material and methods: CPRE files and reports were reviewed, from January 01, 2018 to December 31, 2018. It is an observational, descriptive, retrospective and cross-sectional study. Descriptive statistics and calculation of proportions were performed. All measurement parameters were taken from the ASGE guidelines. The data were represented by the percentage that was achieved for each indicator and the 95% confidence interval (CI) when necessary. Results: 606 ERCPs were included. There were 395 women (65.5%) and 208 (34.5%) were men. The age range was from 2 to 91 years, average age of 48 years. The quality of the ERCP with the performance objectives established by ASGE for almost all the indicators were carried out. The adverse events reported in our series correlate with what is described in the world literature. Conclusion: The present study can be a useful way to guarantee the performance of ERCPs of a better quality in our hospital, as well as being able to perform them in an appropriate manner in any circumstance and pathology. We also have certified endoscopists who comply with the number of appropriate procedures, so teaching is feasible and necessary.
Resumen Introducción: La colangiopancreatografía retrógrada endoscópica (CPRE) es uno de los procedimientos técnicamente más exigentes y de alto riesgo realizados por endoscopistas gastrointestinales. Las asociaciones de gastroenterología han desarrollado directrices o declaraciones de posición sobre diversos aspectos de los indicadores de calidad y de seguridad en la CPRE. Objetivo: Conocer la frecuencia del apego a los indicadores de calidad en estudios de CPRE recomendados por la Asociación Americana de Endoscopia Gastrointestinal en el Servicio de Endoscopia Gastrointestinal, División de Cirugía General del “Hospital General Manuel Gea González “. Material y métodos: Se revisaron los expedientes y reportes de CPRE, del 01 de Enero de 2018 al 31 de Diciembre de 2018. Es un estudio observacional, descriptivo, retrospectivo y transversal. Se realizó estadística descriptiva y calculo de proporciones. Todos los parámetros de medición se tomaron de las pautas de ASGE. Los datos se representaron por el porcentaje que se logró de cada indicador y los intervalos de confianza (IC) de proporción del 95% cuando fue necesario. Resultados: Se incluyeron 606 CPRE. Fueron 395 mujeres (65.5%) y 208 (34.5%) fueron hombres. El rango de edad fue de 2 a 91 años, edad media de 48 años. La calidad de la CPRE con los objetivos de rendimiento establecidos por ASGE para casi todos los indicadores, fueron llevados acabo. Los eventos adversos informados en nuestra serie correlacionan con lo descrito en la literatura mundial. Conclusión: El presente estudio, puede ser una forma útil para garantizar la realización de las CPRE de una mejor calidad en nuestro hospital, así como poder realizarlos de manera adecuada en cualquier circunstancia y patología. Además contamos con médicos endoscopistas certificados y que cumplen con el numero de procedimientos adecuados, por lo cual la enseñanza es factible y necesaria.
https://doi.org/10.24875/end.m19000105
27 downloads
7.
Fotossensibilização primária em bovinos leiteiros causada por Froelichia humboldtiana
Facebook Twitter
Facebook Twitter
- Other social networks
- Google+
- StambleUpon
- CiteULike
- Mendeley
- Other networks
- Metrics
Knupp, Sheila N.R.
; Borburema, Caio Cesar
; Araújo, Valber O.
; Silva, Thatyana K.F.
; Riet-Correa, Franklin
; Knupp, Leonardo S.
; Lucena, Ricardo B.
.
RESUMO: O presente trabalho foi conduzido com o objetivo de relatar um surto de fotossensibilização causado por Froelichia humboldtiana em bovinos leiteiros no Estado do Rio Grande do Norte, Brasil. Foram examinados animais de uma propriedade rural que apresentavam sintomatologia compatível com fotodermatite. Procedeu-se a coleta de amostras de sangue periférico de cinco bovinos para análise das atividades das enzimas hepáticas gamaglutamiltransferase e aspartatoaminotransferase, além da concentração de bilirrubina total, direta e indireta. Das áreas de pele com lesões de dois animais foram realizadas biópsias. Constatou-se que 15 animais de um rebanho composto por 40 animais apresentaram fotossemsibilização. Os animais tinham histórico de apresentar lesões de fotodermatite aproximadamente 10 dias após pastarem em áreas invadidas por F. humboldtiana. Ao exame clínico dos bovinos leiteiros notou-se que inicialmente apresentavam prurido e hiperemia nas áreas de pele despigmentadas do dorso e úbere, também havia alterações do comportamento. Posteriormente, as áreas hiperêmicas se apresentavam com edema que evoluíam para dermatite ulcerativa, necrotizante e exudativa, com perda de extensas áreas da epiderme. As úlceras eram mais graves nos quatro bovinos que apresentavam automutilação por lambedura. Esses quatro animais foram retirados do pasto e abrigados em local sombreado. Uma semana após, o prurido regrediu e as fissuras da pele passaram a cicatrizar. Porém, as lesões reapareceram logo após os bovinos serem reintroduzidas no pasto infestado por F. humbolditiana. Percebeu-se ainda queda na produção leiteira (redução de 50-60%) das vacas após a instalação de fotodermatite. Porém, os bezerros que ainda eram lactantes e ingeriam o leite nas vacas acometidas por fotossensibilização, não apresentaram sinais de fotodermatite. A histopatologia de biópsias de pele revelou inflamação na derme superficial constituída por mastócitos, linfócitos, e alguns plasmócitos. Na epiderme haviam extensas úlceras, recobertas por crostas, associada a infiltrado neutrofílico. As atividades séricas de AST, GGT e as concentrações de bilirrubina estavam dentro dos valores de referência normais para a espécie bovina. O diagnóstico de fotossensibilização primária associada à ingestão de F. humboldtiana foi baseado na epidemiologia, sinais clínicos, bioquímica sérica, biópsia de pele e reocorrência das lesões após os animais serem reintroduzidos no pasto invadido pela planta. Conclui-se que a F. humboldtiana é uma importante causa de fotossensibilização primária em bovinos leiteiros no semiárido brasileiro e que sua toxina provavelmente não é excretada pelo leite bovino.
ABSTRACT: The present study was conducted with the objective to report an outbreak of photosensitization caused by Froelichia humboldtiana in dairy cattle in the State of Rio Grande do Norte, Brazil. Animals from a rural property with symptoms compatible with photodermatitis were examined. Peripheral blood samples from five cattle were collected for the analysis of the activities of hepatic enzymes gammaglutamyltransferase and aspartate aminotransferase, in addition were also analysed the concentration of total, direct and indirect bilirubin. From the areas of skin with lesions of two animals, biopsies were performed. It was verified that 15 animals from a herd composed by 40 animals presented photosensitization. The animals had a history of photodermatitis lesions approximately 10 days after grazing in areas invaded by F. humboldtiana. Clinical examination of dairy cattle showed that they initially had pruritus and hyperemia in the depigmented areas of the dorsum and udder, and there were also behavioral changes. Subsequently, the hyperemic areas presented edema that evolved to ulcerative, necrotizing and exudative dermatitis, with loss of extensive areas of the epidermis. The ulcers were more severe in four bovines that had self-mutilation by licking. These four animals were removed from the pasture and sheltered in a shady location. A week later, the pruritus regressed and the fissures of the skin began to heal. However, the lesions reappeared after the cattle were reintroduced in the grass infested by F. humbolditiana. There was also a decrease in milk production (reduction of 50-60%) of cows after the installation of photodermatitis. However, calves that were still lactating and ingested the milk in photosensitized cows, showed no signs of photodermatitis. Histopathology of skin biopsies revealed inflammation in the superficial dermis consisting of mast cells, lymphocytes, and some plasma cells. In the epidermis there were extensive ulcers, covered by crusts, associated with neutrophilic infiltrate. Serum activities of AST, GGT and bilirubin concentrations were within normal reference values for the bovine species. The diagnosis of primary photosensitization associated with F. humboldtiana ingestion was based on epidemiology, clinical signs, serum biochemistry, skin biopsy and lesion reoccurrence after the animals were reintroduced in the pasture invaded by the plant. It is concluded that F. humboldtiana is an important cause of primary photosensitization in dairy cattle in the Brazilian semi-arid region and that its toxin is probably not excreted by bovine milk.
https://doi.org/10.1590/1678-5150-pvb-5238
3308 downloads
8.
Zoneamento agroclimático para a cultura do pinhão-manso no estado de Pernambuco
Facebook Twitter
Facebook Twitter
- Other social networks
- Google+
- StambleUpon
- CiteULike
- Mendeley
- Other networks
- Metrics
Possas, José M. C.
; Correa, Marcus M.
; Moura, Geber B. de A.
; Lopes, Pabrício M. O.
; Caldas, Anildo M.
; Fontes Júnior, Robertson V. de P.
.
Revista Brasileira de Engenharia Agrícola e Ambiental
- Journal Metrics
Propõe-se, com o presente trabalho, realizar o zoneamento agroclimático da cultura do pinhão-manso (Jathopra curcas L.) no estado de Pernambuco, motivo pelo qual foram utilizados dados climáticos de temperatura do ar média e precipitação pluviométrica de 146 postos meteorológicos, dos quais 73 com série histórica de dados acima de 30 anos e outros 73 com série abaixo de 30 anos porém maior que 20 anos de observações. A escolha do pinhão-manso foi motivada pelo potencial desta cultura como fonte de energia renovável em substituição aos combustíveis fósseis, tanto quanto pela sua rusticidade, tornando-se uma nova opção para regiões de clima semiárido, como ocorre em grande parte da região Nordeste. A seleção da região de estudo está relacionada à variabilidade climática apresentada por esse estado e ao potencial que a referida cultura tem em se desenvolver em regiões nas quais a chuva é escassa. De acordo com o estudo, o Estado de Pernambuco apresenta 14,92% de áreas aptas ao cultivo do pinhão-manso, 44,26% de áreas restritas por deficiência hídrica e 40,82% de áreas inaptas.
This study aimed to realize the agroclimatic zoning of Jathopra curcas L. crop in the State of Pernambuco. For this, climatic data of air temperature and mean rainfall of 146 meteorological stations and 73 series with historical data over 30 years and another 73 with less than 30 years but more than 20 years of observations were used. The choice of Jatropha has been motivated by the potential of this crop as a source of renewable energy to replace fossil fuels as well as for its rusticity and a new option for regions of semi-arid climate, as it occurs in the Northeast region. The selection of the study area is related to climate variability in the State and the potential that this crop has in regions where there is low precipitation. According to the study, the State of Pernambuco has 14.92% of areas suitable for production of Jatropha, 44.26% of the restricted areas by water deficit, and 40.82% of unsuitable areas.
4214 downloads
9.
Resúmenes
Facebook Twitter
Facebook Twitter
- Other social networks
- Google+
- StambleUpon
- CiteULike
- Mendeley
- Other networks
- Metrics
Abad, P.
; Abreu, P.
; Acencio, N.
; Acevedo, S.
; Acevedo, V.
; Agohn, R.
; Albornoz, L.
; Alvarez, P.
; Arana, C.
; Arango, A.
; Arango, J. J.
; Arbeláez, A.
; Arbeláez, L. E.
; Arboleda, W.
; Arenas, A.
; Arenas, I. C.
; Arias, M. L.
; Aristizábal, A.
; Aristizábal, D.
; Arrieta, E.
; Arrieta, M.
; Arroyave, H.
; Arroyo, J. A.
; Arteaga, F.
; Ascione, G.
; Asenjo, R.
; Astudillo, B.
; Atehortúa, L. H.
; Badel, A.
; Badiel, M.
; Balestrini, S.
; Barragán, R.
; Barrera, C.
; Barrera, J. C.
; Barrera, J. G.
; Benítez, L. M.
; Bermúdez, M. J.
; Bernal, O.
; Betancourt, J.
; Betancourt, J.
; Blanco, G.
; Bohórquez, R.
; Bravo, D.
; Bresciani, R.
; Builes, A.
; Buitrago, L
; Burgoa, A.
; Báez, L. P.
; Cabrales, J.
; Cabrales, M.
; Cabrera, C.
; Cadavid, A. M.
; Cadavid, E.
; Cadena, R.
; Caicedo, L. C.
; Caicedo, V.
; Calderón, J.
; Calderón, L. I.
; Camacho, J.
; Camacho, P.
; Camacho, P. A.
; Camargo, D. M.
; Campos, M. T.
; Campuzano, G.
; Capasso, A.
; Cardona, H.
; Cardona, J.
; Carreño, A.
; Carreño, M.
; Carrillo, G.
; Casariego, G.
; Cassalett, G.
; Castellanos, H.
; Castillo, M.
; Castillo, V.
; Castro, H.
; Castro, J.
; Castro, P.
; Cañas, E.
; Celis, A.
; Celis, L. A.
; Chávez, A.
; Chávez, J. C.
; Colorado, A.
; Contreras, E.
; Coral, A.
; Coronado, M.
; Correa, J. R.
; Corredor, S.
; Corzo, L.
; Corzo, O.
; Cotes, J. M.
; Cruz, A.
; Cubides, C.
; Cuellar, F.
; Cuervo, A.
; Cárdenas, A.
; Cárdenas, M.
; Cárdenas, M. E.
; Cárdenas, P. E.
; Cárdenas, W.
; De Viveros, C.
; Delgadillo, A.
; Delgado, J.
; Delgado, P.
; Donado, B. P.
; Donado, J. R.
; Duarte, E.
; Dueñas, R.
; Duque, J. G.
; Duque, M.
; Durango, L.
; Durán, A. E.
; Durán, M. A.
; Dávila, L. M.
; Díaz, A.
; Díaz, A. L.
; Díaz, C.
; Díaz, G.
; Díaz, L.
; Díaz, L. A.
; Díaz, L. H.
; Díaz, L.
; Díaz, M.
; Díaz, S.
; Díaz, V
; Echavarría, J.
; Echeverri, D.
; Echeverri, M.
; Echeverría, L.
; Echeverría, R.
; Erdmenger, J.
; Escobar, A.
; Escobar, C.
; Escobar, E.
; Escorcia, E.
; Espinosa, A.
; Espíndola, R.
; Estrada, G.
; Estrada, J.
; Estupiñán, A. M.
; Eusse, C.
; Fernández, A.
; Fernández, D.
; Fernández, H.
; Fernández, N.
; Fernández, O.
; Fernández, R.
; Flórez, M.
; Fontanilla, M. R.
; Fragozo, C. A.
; Franco, C.
; Franco, G.
; Franco, H. J.
; Franco, J.
; Franco, S.
; Gallo, J.
; Garcés, J.
; García, E.
; García, L.
; Garzón, M. E.
; Gaviria, A.
; Gil, E.
; Giraldo, D.
; Giraldo, J. A.
; Giraldo, JC.
; Giraldo, N.
; Gomesese, O. F.
; González, G.
; González, M.
; González, R.
; Gordillo, M.
; Guanes, R.
; Guerra, P.
; Guerrero, L.
; Guitérrez, L.
; Gulh, F.
; Gutiérrez, J.
; Gutiérrez, M.
; Guyatt, G.
; Guzmán, L.
; Guzmán, N.
; Gárces, J.
; Gómez, A.
; Gómez, C. A.
; Gómez, F.
; Gómez, G.
; Gómez, G. S.
; Gómez, J.
; Gómez, J. F.
; Gómez, M.
; Gómez, P. F.
; Hernández, A.
; Hernández, C.
; Hernández, E.
; Hernández, G.
; Hernández, H.
; Hernández, L.
; Hernández, N.
; Herrera, V. M.
; Hoyos, A.
; Hurtado, E. F.
; Ibarra, P.
; Indaburu, D.
; Iragorri, A.
; Isaza, D.
; Jaimes, F.
; Jaimes, G.
; Jaramillo, C.
; Jaramillo, C. J.
; Jaramillo, G.
; Jaramillo, J.
; Jaramillo, J. C.
; Jaramillo, J. S.
; Jaramillo, M.
; Jaramillo, M. H.
; Jaramillo, N.
; Jaramillo, R.
; Jiménes, M.
; Jiménez, C.
; Jiménez, L.
; Jiménez, L. S.
; Jiménez, M.
; Jurado, A.
; Jurado, A. F.
; Lemus, J.
; Leyes, R.
; León, J.
; Lince, R.
; Lizarazo, J.
; Lizcano, F.
; Llamas, A.
; Llano, J. F.
; Lombo, B.
; Lozano, M.
; Luengas, C.
; Lugo, L. H.
; López, F.
; López, M.
; López, P.
; Malabet, I.
; Maldonado, J.
; Manrique, E. J.
; Manrique, F.
; Mantilla, G.
; Manzi, E.
; Martínez, H.
; Martínez, J. P.
; Martínez, L. X.
; Martínez, M. P.
; Marín, J.
; Mateus, L.
; Matías, N.
; Mayorga, A.
; Medina, A.
; Medina, E.
; Medina, H.
; Mejía,
; Mejía, A.
; Mejía, D.
; Mejía, I.
; Mendoza, S.
; Merchán, A.
; Merlano, S.
; Miranda, A.
; Molina, C.
; Montenegro, J.
; Montero, A.
; Montero, G.
; Montero, G. A.
; Montes, F.
; Montoya, E.
; Montoya, J. D.
; Montoya, L. M.
; Montoya, M.
; Moreno, E.
; Morillo, C.
; Morillo, C. A.
; Morris, R.
; Mosquera, W.
; Moya, L.
; Murgueitio, R.
; Muñoz, A.
; Mármol, J. A.
; Márquez, A.
; Múnera, A.
; Nader, C.
; Navas, C. M.
; Navia, J. J.
; Negrete, A.
; Niño, M. E.
; Náder, C. A.
; Núñez, F.
; Ochoa, J.
; Olaya, C.
; Olaya, L.
; Orjuela, A.
; Orjuela, H.
; Orozco, J. L.
; Orrego, C. M.
; Ortiz, C.
; Ortiz, S. D.
; Osorio, E.
; Ospina, C. A.
; Oviedo, M.
; Oñate, R.
; Pabón, L. M.
; Palomino, G.
; Pardo, C.
; Pardo, R.
; Parra, G. A.
; Parra, J. C.
; Parra, L. E.
; Parra, T.
; Patarroyo, M.
; Pava, L. F.
; Pedraza, J. E.
; Pedraza, O.
; Peláz, A. M.
; Perafán, A.
; Perafán, P.
; Perafán, S.
; Petro, C.
; Pineda, M.
; Pinzón, J. B.
; Pira, P. S.
; Pizarro, C.
; Piñeros, D.
; Plata, R.
; Portilla, P.
; Prada, E.
; Pradilla, G.
; Pulgarín, L. G.
; Páez, G.
; Páez, L.
; Pérez, C.
; Pérez, G. E.
; Pérez, J.
; Pérez, M.
; Quesada, K.
; Quintero, A.
; Quintero, D.
; Quintero, M.
; Quiroz, C.
; Ramos, M. L.
; Ramírez, A.
; Ramírez, I.
; Ramírez, L.
; Ramírez, M.
; Ramírez, O.
; Ramírez, S.
; Rangel, G. W.
; Rendón, J. C.
; Restrepo, A.
; Restrepo, G.
; Restrepo, J. A.
; Reynolds, J.
; Rincón, J. D.
; Rincón, O. S.
; Rincón, P.
; Rivas, G.
; Rivas, L. F.
; Riveros, F.
; Roa, J. L.
; Roa, N.
; Rodríguez, A.
; Rodríguez, D. C.
; Rodríguez, E.
; Rodríguez, J.
; Rojas, C. E.
; Rojas, J. C.
; Romero, M. F.
; Rosas, F.
; Rosas, J. F.
; Rosso, F.
; Rueda, C. L.
; Rueda, M.
; Rueda-Clausen, C. F.
; Ruiz, A.
; Ruiz, D.
; Ruiz, E. J.
; Ruiz, H.
; Ruiz, M.
; Ruz, M.
; Saaibi, J. F.
; Saaibi, L. C.
; Salazar, C.
; Salazar, D.
; Salazar, G.
; Saldarriaga, C.
; Saldoval, N.
; Sanabria, C. L.
; Sandoval, A. G.
; Sandoval, J. M.
; Sandoval, N.
; Sandoval, N. F.
; Santos, H.
; Sarmiento, J. M.
; Satizábal, C.
; Senior, J. M.
; Serano, D.
; Serrano, N. C.
; Silva, F.
; Silva, F. A.
; Silva, S. Y.
; Smieja, M.
; Solano, E.
; Solano, J. A.
; Suárez, M.
; Sáenz, L.
; Tello, J.
; Tenorio, C.
; Tenorio, L. F.
; Thabane, L.
; Tique, C.
; Toro, N.
; Torres, A.
; Torres, G.
; Torres, P.
; Torres, Y.
; Trujillo, P.
; Téllez, M. R.
; Umaña, J.
; Uribe, C. E.
; Uribe, F.
; Uribe, W.
; Urrego, M. T.
; Vacca, M.
; Vallejo, M.
; Vanegas, D.
; Vanegas, D. I.
; Vanegas, E.
; Vargas, C.
; Vargas, R. D.
; Vega, J. A.
; Velasco, H. M.
; Velasco, V. M.
; Velásquez, D.
; Velásquez, J.
; Velásquez, J. G.
; Velásquez, M.
; Velásquez, O.
; Vesga, B. E.
; Vesga, B.E.
; Vidal, C.
; Villa, L. A.
; Villa, V.
; Villa-Roel, C.
; Villalba, J. C.
; Villalobos, C.
; Villamil, C.
; Villamizar, C.
; Villamizar, E.
; Villar, J. C.
; Villegas, A.
; Villegas, F.
; Villegas, F. A.
; Villegas, M. F.
; Vázquez, C.
; Vélez, J. F.
; Vélez, L. A.
; Vélez, S.
; Yabur, M.
; Zapara, J.
; Zapata, H.
; Zapata, J.
; Zarruk, J. G.
; Zuluaga, A.
; Zuluaga, O.
.
1179 downloads
10.
Frequency of the different mutations causing spinocerebellar ataxia (SCA1, SCA2, MJD/SCA3 and DRPLA) in a large group of Brazilian patients
Facebook Twitter
Facebook Twitter
- Other social networks
- Google+
- StambleUpon
- CiteULike
- Mendeley
- Other networks
- Metrics
Lopes-Cendesi, Iscia
; Teive, Hélio G.A.
; Calcagnotto, Maria E
; da Costa, Jaderson C.
; Cardoso, Francisco
; Viana, Erika
; Maciel, Jaime A.
; Radvany, João
; Arruda, Walter O.
; Trevisol-Bittencourt, Paulo C.
; Rosa Neto, Pedro
; Silveira, Isabel
; Steiner, Carlos E.
; Pinto-Júnior, Walter
; Santos, André S.
; Correa Neto, Ylmar
; Werneck, Lineu C.
; Araújo, Abelardo Q.C.
; Carakushansky, Gerson
; Mello, Luiz R.
; Jardim, Laura B.
; Rouleau, Guy A.
.
Ataxia espinocerebelar tipo 1 (SCA1), ataxia espinocerebelar tipo 2 (SCA2) e doença de Machado-Joseph ou ataxia espinocerebelar tipo 3 (MJD/SCA3) são três formas de ataxia espinocerebelar (SCA) que apresentam herança genética autossômica dominante. Nessas três doenças foi encontrada uma expansão instável de trinucleotídeo CAG localizada na região codificadora dos genes responsáveis pelas três doenças. Portanto, para SCA 1, SCA2 e MJD/SCA3 o diagnóstico molecular é agora possível. A atrofia dentatorubropalidoluisiana (DRPLA) é também causada pela expansão de trinucleotídeos CAG e pode por vezes se apresentar como uma SCA. Nós investigamos a freqüência das mutações responsáveis por SCA1, SCA2, MJD/SCA3 e DRPLA em um grupo de 328 pacientes brasileiros com SCA pertencentes a 90 famílias não aparentadas. Esses pacientes apresentavam padrões diferentes de herança genética e eram provenientes de várias regiões do Brasil. Nós identificamos mutações em 35 famílias, 32 das quais com herança claramente autossômica dominante. A freqüência da mutação SGA1 foi de 3% no grupo total de pacientes, e 6% nos pacientes com herança autossômica dominante. Nós encontramos a mutação SCA2 em 6% de todas as famílias e em 9% das famílias com herança autossômica dominante. A mutação MJD/SCA3 foi encontrada em 30% de todos os pacientes, e em 44% quando consideramos somente os pacientes com herança autossômica dominante. Nenhuma mutação DRPLA foi encontrada. Nós observamos também variabilidade na freqüência das diferentes mutações em pacientes provenientes de diferentes regiões geográficas, o que provavelmente se correlaciona com os padrões distintos de colonização do Brasil. Nossos resultados sugerem que os casos de SCA no Brasil podem ser causados ocasionalmente pela mutação SCA1 e SCA2, mas que a causa mais freqüente de SCA de herança autossômica dominante no Brasil é a mutação MJD/SCA3.
Spinocerebellar ataxia type 1 (SCA1), spinocerebellar ataxia type 2 (SCA2) and Machado-Joseph disease or spinocerebellar ataxia type 3 (MJD/SCA3) are three distinctive forms of autosomal dominant spinocerebellar ataxia (SCA) caused by expansions of an unstable CAG repeat localized in the coding region of the causative genes. Another related disease, dentatorubropallidoluysian atrophy (DRPLA) is also caused by an unstable triplet repeat and can present as SCA in late onset patients. We investigated the frequency of the SCA1, SCA2, MJD/SCA3 and DRPLA mutations in 328 Brazilian patients with SCA, belonging to 90 unrelated families with various patterns of inheritance and originating in different geographic regions of Brazil. We found mutations in 35 families (39%), 32 of them with a clear autosomal dominant inheritance. The frequency of the SCA1 mutation was 3% of all patients; and 6 % in the dominantly inherited SCAs. We identified the SCA2 mutation in 6% of all families and in 9% of the families with autosomal dominant inheritance. The MJD/SCA3 mutation was detected in 30 % of all patients; and in the 44% of the dominantly inherited cases. We found no DRPLA mutation. In addition, we observed variability in the frequency of the different mutations according to geographic origin of the patients, which is probably related to the distinct colonization of different parts of Brazil. These results suggest that SCA may be occasionally caused by the SCA1 and SCA2 mutations in the Brazilian population, and that the MJD/SCA3 mutation is the most common cause of dominantly inherited SCA in Brazil.
6209 downloads
Cited 3 times in SciELO
Showing
itens per page
Page
of 1
Next
Statistics of
Send result
Sem resultados
No documents were found for your search
Glossary and search help
You can enrich your search in a very simple way. Use the search indexes combined with the connectors (AND or OR) and specify more your search.
For example, if you want to search for articles about
cases of dengue in Brasil in 2015, use:ti:dengue and publication_year:2015 and aff_country:Brasil
See below the complete list of search indexes that can be used:
Index code | Element |
---|---|
ti | article title |
au | author |
kw | article keywords |
subject | subject (title words, abstract and keywords) |
ab | abstract |
ta | journal short title (e.g. Cad. Saúde Pública) |
journal_title | journal full title (e.g. Cadernos de Saúde Pública) |
la | publication language code (e.g. pt - Portuguese, es - Spanish) |
type | document type |
pid | publication identifier |
publication_year | publication year of publication |
sponsor | sponsor |
aff_country | country code of the author's affiliation |
aff_institution | author affiliation institution |
volume | article volume |
issue | article issue |
elocation | elocation |
doi | DOI number |
issn | journal ISSN |
in | SciELO colection code (e.g. scl - Brasil, col - Colômbia) |
use_license | article usage license code |