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Association between childhood anthropometric indicators and bone mineral density in adulthood
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Freitas, Mileny Caroline Menezes de

; Costa, Julio Cesar da

; Barbosa, Cynthia Correa Lopes

; Zambrin, Lidyane Ferreira

; Romanzini, Catiana Leila Possamai

; Romanzini, Marcelo

; Ronque, Enio Ricardo Vaz

Revista Paulista de Pediatria

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2024, Volume 42 elocation e2023026

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT Objective: This study aimed to verify the association between childhood anthropometric indicators and areal bone mineral density (aBMD) in adulthood. Methods: Repeated measures of 137 subjects (68 females) were obtained in childhood (9.2±1.5 years of age) and adulthood (22.3±1.7 years of age). aBMD (g/cm2) was assessed for whole body, lumbar spine, upper and lower limbs, and femoral neck in adulthood using dual-energy X-ray absorptiometry. Anthropometric measurements of body weight (BW), height, triceps and subscapular skinfolds were obtained in childhood. The anthropometric indicators used were BW, body mass index (BMI), and sum of skinfolds (ΣSF). Simple linear regression was used to assess the association between childhood anthropometric indicators and aBMD in adulthood, controlled by chronological age and stratified by sex, with 5% statistical significance. Results: In females, multiple associations were observed between anthropometric indicators and aBMD, with higher coefficients for BMI (β=0.020; R2=0.20; p<0.01 for right femoral neck to β=0.008; R2=0.16; p<0.01 for upper limbs), followed by BW (β=0.003; R2=0.21; p<0.01 for upper limbs to β=0.008; R2=0.20; p<0.01 for right femoral neck) and ΣSF (β=0.001; R2=0.06; p<0.01 for upper limbs to β=0.005; R2=0.12; p<0.01 for right femoral neck). In males, associations were observed only for the lumbar spine region (β=0.016; R2=0.09 for BMI to β=0.004; R2=0.06; p<0.01 for ΣSF). Conclusions: Anthropometric indicators of childhood proved to be sensitive predictors of aBMD in adulthood, especially in females. BMI indicated a greater association with aBMD in both sexes.

RESUMO Objetivo: O objetivo do estudo foi verificar a associação entre os indicadores antropométricos da infância com a área da densidade mineral óssea (aDMO) na idade adulta. Métodos: Medidas repetidas de 137 sujeitos (68 do sexo feminino) foram obtidos na infância (9,2±1,5 anos de idade) e idade adulta (22,3±1,7 anos de idade). A aDMO (g/cm2) foi avaliada para todo o corpo, coluna lombar, membros superiores e inferiores e colo do fêmur na idade adulta usando a absorciometria radiológica de dupla energia (DXA). Medidas antropométricas de peso corporal, estatura e dobras cutâneas das regiões tricipital e subescapular foram obtidas na infância. Os indicadores antropométricos utilizados para as análises foram o peso corporal (PC), o índice de massa corporal (IMC) e o somatório de dobras cutâneas (ΣDC). Regressão linear simples controlada pela idade e estratificada por sexo foi empregada para avaliar a associação entre os indicadores antropométricos do período da infância na aDMO na idade adulta, com significância estatística de 5%. Resultados: No sexo feminino, múltiplas associações foram observadas entre os indicadores antropométricos e a aDMO, com maiores coeficientes para IMC (β=0,020; R2=0,20; p<0.01 para colo do fêmur direito a β=0,008; R2=0,16; p<0,01 para membros superiores), seguido da PC (β=0,003; r2=0,21; p<0,01 para membros superiores a β=0,008; r2=0,20; p<0,01 para colo do fêmur direito) e ΣDC (β=0,001; R2=0,06; p<0,01 para membros superiores a β=0,005; R2=0,12; p<0,01 para colo do fêmur direito). No sexo masculino, associações ocorreram apenas na região da coluna (β=0,016; R2=0,09 para IMC a β=0,004; R2=0,06; p<0,01 para ΣDC). Conclusões: Indicadores antropométricos da infância mostraram ser sensíveis preditores da aDMO na idade adulta, especialmente no sexo feminino. O IMC indicou maior associação com a aDMO em ambos os sexos.

https://doi.org/10.1590/1984-0462/2024/42/2023026

Procrastinación académica en estudiantado de medicina del Paraguay en 2022
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Real Delor, Raúl Emilio

; Acosta Sánchez, Rilci Araceli

; Arrua Gaona, Charles Enrique

; Cabrera Dávalos, Luis Alberto

; Cáceres Huispe, Marcelo Agustín

; Correa Escobar, Laura Josefina

; Duarte Rodríguez, Mayra Alejandra

; Gómez, Orlando de Jesús

; Ortiz Villalba, David Israel

; Ramírez,, Johanna de María

; Ruiz Diaz Llanes, Jessica Nicoll

; Segovia Fernández, Daniel

; Trinidad Segovia, Oscar Danilo

; Monges Coiteux, Vanina Soldad

Revista Educación

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dec 2023, Volume 47 N. 2 Pages 433 - 453

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Los objetivos fueron evaluar el nivel de procrastinación académica del estudiantado de medicina del Paraguay en 2022 y describir sus características sociodemográficas. Se realizó un estudio observacional, de corte transversal. Se aplicó el cuestionario de García-Martínez y Silva (2019)constituido por 22 preguntas basadas en la escala de Likert, el cual fue difundido por las redes sociales de estudiantes de universidades públicas y privadas del Paraguay entre mayo y octubre 2022 . El nivel de procrastinación se determinó por las dimensiones postergación de tareas, autorregulación académica e influencia de la tecnología, además, se evaluaron variables sociodemográficas. Las variables fueron sometidas a un análisis factorial exploratorio para indagar las dimensiones subyacentes, constructos o variables latentes observadas. La investigación fue aprobada por el Comité de ética de la Universidad Privada del Este, Paraguay. Se encuestaron 188 estudiantes, con predominio del sexo femenino (64.9%). La edad media fue 24 ± 4 años, un 31.9% reside en Asunción, 81.4% carece de ingresos económicos propios. En conclusión, se detectó procrastinación en 73 estudiantes (38.8%) de medicina. Se recomienda investigar las causas de esta situación.

Abstract As main objectives, this research aims to determine the level of academic procrastination of medical students in Paraguay in 2022 and describe their sociodemographic characteristics. For this, the researchers conducted an observational cross-sectional study. Likewise, they applied the García-Martínez and Silva (2019) questionnaire, which was disseminated through the social networks of students from public and private universities in Paraguay between May and October 2022. Procrastination was determined with the dimensions of task postponement, academic self-regulation and the influence of technology using 22 questions, answered with a scale of Likert. Sociodemographic variables were also evaluated. The variables were submitted to an exploratory factor analysis to investigate the underlying dimensions, constructs, or latent variables observed. The research was approved by the Ethics Committee of the Universidad Privada del Este, Paraguay. The researchers surveyed 188 students, with a predominance of females (64.9%). The average age was 24 ± 4 years, 31.9% reside in Asunción, and 81.4% lack their own economic income. Procrastination was detected in 73 students (38.8%). In conclusion, procrastination was detected in 38.8% of medical students; therefore, it is recommended to investigate the causes of this situation.

https://doi.org/10.15517/revedu.v47i2.53617

Mobile phones of anesthesiologists as reservoirs of nosocomial bacteria in a quaternary teaching hospital: an observational study
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Correa, Guilherme Haelvoet

; Formigoni, Carla de Souza

; Sasagawa, Suzethe Matiko

; Arnoni, Mariana Volpe

; Mathias, Lígia Andrade da Silva Telles

; Mimica, Marcelo Jennè

Brazilian Journal of Anesthesiology

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may 2023, Volume 73 N. 3 Pages 276 - 282

Abstract: En | Text: En | PDF: En

Abstract Background: Mobile phones in hospital settings have been identified as an important source of cross-contamination because of the low frequency with which mobile phones are cleaned by health workers and cyclical contamination of the hands and face. The aim of this study was to investigate whether the mobile phones of the anesthesia team at a teaching hospital are potential reservoirs of nosocomial bacteria. In addition, differences in device sanitization and hand hygiene habits between attending and resident anesthesiologists were correlated with mobile phone colonization. Methods: A prevalence study was conducted over a 6-month period from 2017 to 2018 that involved the collection of samples from the mobile phones of the anesthesiology team and culturing for surveillance. A questionnaire was administered to assess the mobile phone sanitization and hand washing routines of the anesthesia team in specific situations. Results: Bacterial contamination was detected for 86 of the 128 mobile phones examined (67.2%). A greater presence of Micrococcus spp. on devices was correlated with a higher frequency of mobile phone use (p = 0.003) and a lower frequency of sanitization (p = 0.003). The presence of bacteria was increased on the mobile phones of professionals who did not perform handwashing after tracheal intubation (p = 0.003). Conclusion: Hand hygiene and device sanitization habits were more important than the use behavior, as a higher presence of bacteria correlated with poorer hygiene habits. Furthermore, handwashing is the best approach to prevent serious colonization of mobile devices and the possible transmission of pathogens to patients under the care of anesthesiologists.

https://doi.org/10.1016/j.bjane.2021.08.013

Analysis of risk factors associated with cerebral angiography headache
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Madeira, Tiago

; Correa, Amanda Viguini Tolentino

; Abranches, Gabriela de Paula

; Masruha, Marcelo Rodrigues

Arquivos de Neuro-Psiquiatria

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apr 2023, Volume 81 N. 4 Pages 334 - 339

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Background Despite previous studies indicating a moderate/high incidence of angiography headache (AH), there is still limited data about the risk factors associated with its occurrence. Objective The present study aimed to assess the associations among demographic, clinical, and technical characteristics of cerebral digital subtraction angiography (DSA) and the occurrence of AH. Methods Cross-sectional analytical observational study with a sample comprised of individuals with a recommendation for elective DSA. Clinical interviews were conducted to assess the occurrence of AH, using a standardized questionnaire. Results Among 114 subjects, the mean age was 52.8 (±13.8) years old, 75.4% (86/114) were women, 29.8% (34/114) had a history of migraines, and 10.5% (12/114) had chronic headaches. The overall frequency of AH was 45.6% (52/114). Of those, 88.4% (46/52) underwent 3D angiography, 7.7% (4/52) underwent aortography, and 1.9% (1/52) underwent both procedures. There was a statistically significant association between AH and previous history of migraine (odds ratio [OR]: 4.9; 95% confidence interval [CI] 1.62–14.7; p = 0.005) and 3D angiography (OR 6.62; 95%CI: 2.04–21.5; p = 0.002). Conclusions 3D angiography is strongly associated with the occurrence of AH, which has never been reported before. The association between a previous history of migraine and AH confirms the results of previous studies.

Resumo Antecedentes Apesar de estudos prévios indicarem uma incidência moderada/alta de cefaleia da angiografia (CA), os dados sobre os fatores de risco associados à sua ocorrência ainda são relativamente escassos. Objetivo O presente estudo teve como objetivo avaliar as associações entre as características demográficas, clínicas e técnicas da angiografia cerebral por subtração digital (ACSD) e a ocorrência de CA. Métodos Estudo observacional analítico transversal com uma amostra composta por indivíduos com indicação de ACSD em caráter eletivo. Entrevistas clínicas foram realizadas utilizando um questionário padronizado para acessar a ocorrência de CA. Resultados Entre os 114 indivíduos, a idade média foi de 52,8 (±13,8) anos, 75,4% (86/114) eram mulheres, 29,8% (34/114) tinham histórico de enxaqueca e 10,5% (12/114) tinham cefaleia crônica. A frequência geral de CA foi de 45,6% (52/114). Desses, 88,4% (46/52) foram submetidos à angiografia 3D, 7,7% (4/52), à aortografia e 1,9% (1/52), aos dois procedimentos. Houve associação estatisticamente significativa entre CA e histórico prévio de enxaqueca (odds ratio [OR] 4,9; intervalo de confiança [IC] 95%: 1,62–14,7; p = 0,005) e angiografia 3D (OR 6,62; IC95%: 2,04–21,5; p = 0,002). Conclusões A angiografia 3D está fortemente associada à ocorrência de CA, o que é inédito na literatura. A associação entre um histórico de enxaqueca e a CA confirma os resultados de estudos anteriores.

https://doi.org/10.1055/s-0043-1768157

Occult hepatitis B virus infection in patients with chronic liver disease of different etiology in a Brazilian referral center: comparison of two different hepatitis B virus deoxyribonucleic acid amplification protocols: a cross-sectional study
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Faria, Alessandra Coutinho de

; Correa, Bernardo Henrique Mendes

; Faria, Luciana Costa

; Vidigal, Paula Vieira Teixeira

; Xavier, Marcelo Antônio Pascoal

; Ferrari, Teresa Cristina Abreu

Sao Paulo Medical Journal

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2023, Volume 141 N. 3 elocation e2022147

Abstract: En | Text: En | PDF: En

ABSTRACT BACKGROUND: Occult hepatitis B virus infection (OBI) is defined as the presence of hepatitis B virus (HBV) deoxyribonucleic acid (DNA) in the liver of individuals with undetectable hepatitis B virus surface antigen (HBsAg) in the serum. The actual prevalence of OBI and its clinical relevance are not yet fully understood. OBJECTIVE: To evaluate the prevalence of HBV DNA in liver biopsies of HBsAg-negative patients with chronic liver disease of different etiologies in a referral center in Brazil and compare two different HBV DNA amplification protocols to detect HBV. DESIGN AND SETTING: This cross-sectional observational study was conducted at the Liver Outpatient Clinic, Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil, between January 2016 and December 2019. METHODS: HBV DNA was investigated in 104 liver biopsy samples from individuals with chronic liver disease of different etiologies, in whom HBsAg was undetectable in serum by nested-polymerase chain reaction (nested-PCR), using two different protocols. RESULTS: OBI, diagnosed by detecting HBV DNA using both protocols, was detected in 6.7% of the 104 individuals investigated. Both protocols showed a good reliability. CONCLUSION: In addition to the differences in the prevalence of HBV infection in different regions, variations in the polymerase chain reaction technique used for HBV DNA amplification may be responsible for the large variations in the prevalence of OBI identified in different studies. There is a need for better standardization of the diagnostic methods used to diagnose this entity.

https://doi.org/10.1590/1516-3180.2022.0147.r1.12072022

Avaliação de aplicativos tecnológicos na mensuração de abertura de dossel na Floresta Ombrófila Mista
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Pinho, Leandro Correa

; Scipioni, Marcelo Callegari

; Siminski, Alexandre

Ciência Florestal

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2023, Volume 33 N. 2 elocation e67685

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT Canopy opening is an important variable for understanding the regeneration of plant species and the floristic composition of forest environments. Smartphone applications have been created to estimate the openness and coverage of community structures and plant culture. These have the potential to replace conventional equipment such as the Densiometer due to accessibility and zero cost. However, measuring and recommending the use of these technologies to the forest environment is necessary. Thus, the present study aimed to evaluate these low-cost technologies for measuring the canopy opening / covering by comparing with the spherical Densiometer model A. Canopy openings were measured for each method at 55 points performing 4 readings per point on permanent plots in Araucaria Forest fragment. The means of the canopy opening measurements for each method were compared by statistical test. The results obtained were that the CanopyCapture application presented better results, not differing statistically from the Densiometer; CanopyCapture proved to be an intermediate alternative; Canopeo performed worse, with great variation and little precision in the results. It was possible to conclude that, for the proposed study model, only CanopyCapture has the potential to be used as a substitute for the Forest Densiometer, yet different studies are necessary to have greater reliability in the efficiency of this application in other forest formations.

RESUMO A abertura do dossel é uma variável importante para o entendimento da regeneração de espécies vegetais e na composição florística dos ambientes florestais. Aplicativos de Smartphones foram criados para estimativas de abertura e cobertura estrutural de comunidades e plantas, apresentando potencial de substituição de equipamentos convencionais como o Densiômetro, devido à acessibilidade e ao custo zero. Assim, o presente estudo teve por objetivo avaliar essas tecnologias de baixo custo para a mensuração da abertura/cobertura de dossel florestal comparando com o Densiômetro esférico modelo A. Foram medidas as aberturas de dossiês para cada método em 55 pontos realizando 4 leituras por ponto em parcelas permanentes em fragmento de Floresta Ombrófila Mista. As médias das medidas de abertura de dossel de cada método foram comparadas por teste de estatísticos. Os resultados obtidos foram que o aplicativo CanopyCapture apresentou melhores resultados não diferindo estatisticamente do Densiômetro; o CanopyCapture demonstrou-se uma alternativa intermediária; o Canopeo apresentou pior desempenho, tendo grande variação e pouca precisão nos resultados. Foi possível concluir que, no ambiente e modelo de estudo proposto, apenas o CanopyCapture possui potencial para uso como substituto do Densiômetro Florestal, ainda assim é necessários diferentes estudos para que se tenha uma maior confiabilidade na eficiência desse aplicativo em outras formações florestais.

https://doi.org/10.5902/1980509867685

Inflamação Coronária Avaliada pela Atenuação de Gordura Pericoronária na Tomografia Computadorizada e Elevação de Citocinas em Usuários Jovens de Esteroides Anabólicos Androgênicos
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Souza, Francis Ribeiro de

; Rochitte, Carlos E.

; Silva, Douglas Carli

; Sampaio, Barbara

; Passarelli, Marisa

; Santos, Marcelo R. dos

; Fonseca, Guilherme W.

; Battaglia Filho, Antonio Carlos

; Correa, Kelly

; do Val, Renata Margarida

; Yonamine, Maurício

; Pereira, Rosa Maria R.

; Negrão, Carlos Eduardo

; Kalil-Filho, Roberto

; Alves, Maria Janieire de Nazaré Nunes

Arquivos Brasileiros de Cardiologia

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2023, Volume 120 N. 11 elocation e20220822

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Background Anabolic androgenic steroid (AAS) abuse has been associated with coronary artery disease (CAD). Pericoronary fat attenuation (pFA) is a marker of coronary inflammation, which is key in the atherosclerotic process. Objective To evaluate pFA and inflammatory profile in AAS users. Methods Twenty strength-trained AAS users (AASU), 20 AAS nonusers (AASNU), and 10 sedentary controls (SC) were evaluated. Coronary inflammation was evaluated by mean pericoronary fat attenuation (mPFA) in the right coronary artery (RCA), left anterior descending coronary artery (LAD), and left circumflex (LCx). Interleukin (IL)-1 (IL-1), IL-6, IL-10, and TNF-alpha were evaluated by optical density (OD) in a spectrophotometer with a 450 nm filter. P<0.05 indicated statistical significance. Results AASU had higher mPFA in the RCA (-65.87 [70.51-60.70] vs. -78.07 [83.66-72.87] vs.-78.46 [85.41-71.99] Hounsfield Units (HU), respectively, p<0.001) and mPFA in the LAD (-71.47 [76.40-66.61] vs. -79.32 [84.37-74.59] vs. -82.52 [88.44-75.81] HU, respectively, p=0.006) compared with AASNU and SC. mPFA in the LCx was not different between AASU, AASNU, and SC (-72.41 [77.17-70.37] vs. -80.13 [86.22-72.23] vs. -78.29 [80.63-72.29] HU, respectively, p=0.163). AASU compared with AASNU and SC, had higher IL-1, (0.975 [0.847-1.250] vs. 0.437 [0.311-0.565] vs. 0.530 [0.402-0.780] OD, respectively, p=0.002), IL-6 (1.195 [0.947-1.405] vs. 0.427 [0.377-0.577] vs. 0.605 [0.332-0.950] OD, p=0.005) and IL-10 (1.145 [0.920-1.292] vs. 0.477 [0.382-0.591] vs. 0.340 [0.316-0.560] OD, p<0.001). TNF-α was not different between the AASU, AASNU, and SC groups (0.520 [0.250-0.610] vs. 0.377 [0.261-0.548] vs. 0.350 [0.182-430]), respectively. Conclusion Compared with ASSNU and controls, AASU have higher mPFA and higher systemic inflammatory cytokines profile suggesting that AAS may induce coronary atherosclerosis through coronary and systemic inflammation.

Resumo Fundamento O uso abusivo de esteroides anabólicos androgênicos (EAA) tem sido associado à doença arterial coronariana (DAC). A atenuação de gordura pericoronária (AGp) é um marcador de inflamação coronária, a qual exerce um papel chave no processo aterosclerótico. Objetivo Avaliar AGp e perfil inflamatório em usuários de EAA. Método Vinte indivíduos que realizavam treinamento de força, usuários de EAA (UEAA), 20 não usuários de EAA (NUEAA), e 10 indivíduos sedentários controle (SC) foram avaliados. Inflamação coronária foi avaliada por atenuação de gordura pericoronária média (AGPm) artéria coronária direita (ACD), artéria descendente anterior esquerda (ADA) e artéria circunflexa (ACX). Interleucina (IL)-1 (IL-1), IL-6, IL-10, e TNF-alfa foram avaliados por densidade ótica (DO) em um espectrofotômetro com um filtro de 450 nm. Um p<0,05 indicou significância estatística. Resultados Os UEAA apresentaram maior AGPm na ACD [-65,87 (70,51-60,70) vs. -78,07 (83,66-72,87) vs.-78,46 (85,41-71,99] unidades Hounsfield (HU), respectivamente, p<0,001) e AGPm na ADA [-71,47 (76,40-66,610 vs. -79,32 (84,37-74,59) vs. -82,52 (88,44-75,81) HU, respectivamente, p=0,006) em comparação aos NUEAA e CS. A AGPm na ACX não foi diferente entre os grupos UEAA, NUEAA e CS [-72,41 (77,17-70,37) vs. -80,13 (86,22-72,23) vs. -78,29 (80,63-72,29) HU, respectivamente, p=0,163). Em comparação aos NUEAA e aos CS, o grupo UEAA apresentaram maiores níveis de IL-1 [0,975 (0,847-1,250) vs. 0,437 (0,311-0,565) vs. 0,530 (0,402-0,780) DO, respectivamente, p=0,002), IL-6 [1,195 (0,947-1,405) vs. 0,427 (0,377-0,577) vs. 0,605 (0,332-0,950) DO, p=0,005) e IL-10 [1,145 (0,920-1,292) vs. 0,477 (0,382-0,591) vs. 0,340 (0,316-0,560) DO, p<0,001]. TNF-α não foi diferente entre os grupos UEAA, NUEAA e CS [0,520 (0,250-0,610) vs. 0,377 (0.261-0,548) vs. 0,350 (0,182-430)]. Conclusão Em comparação aos NUEAA e controles, os UEAA apresentam maior AGPm e maior perfil de citocinas inflamatórias sistêmicas, sugerindo que os EAA podem induzir aterosclerose por inflamação coronária e sistêmica.

https://doi.org/10.36660/abc.20220822

The SISBIOTA-Diptera Brazilian Network: A long-term survey of Diptera from unexplored Brazilian Western Arc of Amazon, Cerrado, and Pantanal
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Lamas, Carlos José Einicker

; Fachin, Diego Aguilar

; Falaschi, Rafaela Lopes

; Alcantara, Daniel Máximo Correa de

; Ale-Rocha, Rosaly

; Amorim, Dalton de Souza

; Araújo, Maíra Xavier

; Ascendino, Sharlene

; Baldassio, Letícia

; Bellodi, Carolina Ferraz

; Bravo, Freddy

; Calhau, Julia

; Capellari, Renato Soares

; Carmo-Neto, Antonio Marcelino do

; Cegolin, Bianca Melo

; Couri, Márcia Souto

; Carvalho, Claudio José Barros de

; Dios, Rodrigo de Vilhena Perez

; Falcon, Aida Vanessa Gomez

; Fusari, Livia Maria

; Garcia, Carolina de Almeida

; Gil-Azevedo, Leonardo Henrique

; Gomes, Marina Morim

; Graciolli, Gustavo

; Gudin, Filipe Macedo

; Henriques, Augusto Loureiro

; Krolow, Tiago Kütter

; Mendes, Luanna Layla

; Limeira-de-Oliveira, Francisco

; Maia, Valéria Cid

; Marinoni, Luciane

; Mello, Ramon Luciano

; Mello-Patiu, Cátia Antunes de

; Morales, Mírian Nunes

; Oliveira, Sarah Siqueira

; Patiu, Claudemir

; Proença, Barbara

; Pujol-Luz, Cristiane Vieira de Assis

; Pujol-Luz, José Roberto

; Rafael, José Albertino

; Riccardi, Paula Raile

; Rodrigues, João Paulo Vinicios

; Roque, Fabio de Oliveira

; Sallum, Maria Anice Mureb

; Santis, Marcelo Domingos de

; Santos, Charles Morphy Dias dos

; Santos, Josenilson Rodrigues dos

; Savaris, Marcoandre

; Shimabukuro, Paloma Helena Fernandes

; Silva, Vera Cristina

; Schelesky-Prado, Daniel de Castro

; Silva-Neto, Alberto Moreira da

; Camargo, Alexssandro

; Sousa, Viviane Rodrigues de

; Urso-Guimarães, Maria Virginia

; Wiedenbrug, Sofia

; Yamaguchi, Carolina

; Nihei, Silvio Shigueo

Revista Brasileira de Entomologia

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2023, Volume 67 N. 4 elocation e20230051

Abstract: En | Text: En | PDF: En

ABSTRACT The SISBIOTA-BRASIL was a three-year multimillion-dollar research program of the Brazilian government to document plants and animals in endangered/understudied areas and biomes in Brazil. Distributional patterns and the historical events that generated them are extensively unknown regarding Brazilian fauna and flora. This deficiency hinders the development of conservation policies and the understanding of evolutionary processes. Conservation decisions depend on precise knowledge of the taxonomy and geographic distribution of species. Given such a premise, we proposed to research the diversity of Diptera of the Brazilian western arc of Amazon, Cerrado, and Pantanal in the states of Mato Grosso, Mato Grosso do Sul, and Rondônia. Three important biomes of the South American continent characterize these Brazilian states: Amazon forest, Cerrado (Brazilian Savannah), and Pantanal. Besides their ecological relevance, these biomes historically lack intensive entomological surveys. Therefore, they are much underrepresented in the Brazilian natural history collections and in the scientific literature, which is further aggravated by the fact that these areas are being exponentially and rapidly converted to commercial lands. Our project involved over 90 collaborators from 24 different Brazilian institutions and one from Colombia among researchers, postdocs, graduate and undergraduate students, and technicians. We processed and analyzed nearly 300,000 specimens from ~60 families of Diptera collected with a large variety of methods in the sampled areas. Here, we provide a detailed overview of the genera and species diversity of 41 families treated. Our results point to a total of 2,130 species and 514 genera compiled and identified for the three states altogether, with an increase of 41% and 29% in the numbers of species and genera known for the three states combined, respectively. Overall, the 10 most species-rich families were Tachinidae, Cecidomyiidae, Tabanidae, Psychodidae, Sarcophagidae, Stratiomyidae, Bombyliidae, Syrphidae, Tephritidae, and Asilidae. The 10 most diverse in the number of genera were Tachinidae, Stratiomyidae, Asilidae, Mycetophilidae, Syrphidae, Tabanidae, Muscidae, Dolichopodidae, Sarcophagidae, and Chloropidae. So far, 111 scientific papers were published regarding taxonomic, phylogenetic, and biogeographical aspects of the studied families, with the description of 101 new species and three new genera. We expect that additional publications will result from this investigation because several specimens are now curated and being researched by specialists.

https://doi.org/10.1590/1806-9665-rbent-2023-0051

Magnetic resonance imaging findings in patients with polymyalgia rheumatica
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Leão, Renata Vidal

; Calich, Ana Luisa Garcia

; Calich, Isidio

; Rodrigues, Marcelo Bordalo

; Helito, Paulo Victor Partezani

; Amaral, Denise Tokechi

; Pereira, Renata Fernandes Batista

; Correa, Marcos Felippe de Paula

Radiologia Brasileira

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nov 2022, Volume 55 N. 6 Pages 346 - 352

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Objetivo: Descrever os achados de ressonância magnética (RM) mais prevalentes em pacientes com diagnóstico clínico de polimialgia reumática (PMR). Materiais e Métodos: Dezesseis pacientes com PMR não tratada, classificados pelos critérios do American College of Rheumatology, foram submetidos a RM do ombro e/ou quadril, segundo suas queixas clínicas. Seis pacientes também foram submetidos a RM da coluna. Resultados: Foram avaliados 24 ombros, identificando-se bursite subacromial-subdeltoide em 21 (87,5%), sinovite glenoumeral em 17 (70,8%) e distensão líquida da bainha do tendão da cabeça longa do bíceps em 15 (62,5%). Peritendinite e edema capsular foram observados em 21 (87,5%) e 17 (70,8%) ombros, respectivamente. Dezessete quadris foram analisados, identificando-se sinovite em 12 (70,6%), bursite trocantérica em 11 (64,7%), peritendinite em 17 (100%) e edema capsular em 14 (82,4%). Os seis pacientes que realizaram RM da coluna apresentavam bursite interespinhosa. Conclusão: Bursite subacromial-subdeltoide, sinovite glenoumeral e do quadril são achados de imagem prevalentes em pacientes com PMR. Além disso, achados como peritendinite e edema capsular tiveram alta prevalência nesses pacientes. Estudos de caso- controle devem ser realizados para validar esses dados e estabelecer o real impacto desses achados no diagnóstico de PMR.

Abstract Objective: To describe the prevalence of magnetic resonance imaging (MRI) findings in patients with the clinical diagnosis of polymyalgia rheumatica (PMR). Materials and Methods: Sixteen consecutive patients with untreated PMR, meeting the American College of Rheumatology criteria, underwent MRI examinations of the shoulder(s), hip(s), or both, depending on clinical complaints. Six patients also underwent MRI of the spine. Results: We evaluated 24 shoulders, among which we identified subacromial-subdeltoid bursitis in 21 (87.5%), glenohumeral joint effusion in 17 (70.8%), and fluid distention of the long head of the biceps tendon sheath in 15 (62.5%). Peritendinitis and capsular edema were observed in 21 (87.5%) and 17 (70.8%) shoulders, respectively. We also evaluated 17 hips, identifying hip joint effusion in 12 (70.6%), trochanteric bursitis in 11 (64.7%), peritendinitis in 17 (100%), and capsular edema in 14 (82.4%). All six of the patients who underwent MRI of the spine were found to have interspinous bursitis. Conclusion: Subacromial-subdeltoid bursitis, glenohumeral joint effusion, and hip joint effusion are common findings in patients with PMR. In addition, such patients appear to be highly susceptible to peritendinitis and capsular edema. There is a need for case-control studies to validate our data and to determine the real impact that these findings have on the diagnosis of PMR by MRI.

https://doi.org/10.1590/0100-3984.2021.0151

10.

Morphometric Study of Extra-Hepatic Biliary Pathways - Study in Human Corpses
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Santos Conceição, Danielly de Cássia

; Gonçalves, Giuliano R

; Scabora, José Eduardo

; Martinez Oliveira, Kennedy

; Correa Maldonado, Diogo

; Pereira da-Silva, Marcelo Cavenaghi

; Grecco, Leandro H

International Journal of Morphology

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feb 2022, Volume 40 N. 1 Pages 228 - 232

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

SUMMARY: Adverse events (AE) contribute significantly to postoperative morbidities and comorbidities. Many AEs occur due to a lack of anatomical knowledge and its variants. Latrogenic bile duct injuries, for instance, represent a serious surgical complication of laparoscopic cholecystectomy. Anatomical knowledge for the identification and adequate drainage of all ducts is relevant and fundamental in order to avoid future errors. The objective of the study was to morphometrically analyze the bile ducts in adult human corpses. 13 livers were extracted from adult human corpses to obtain the ducts: choledochal, common hepatic and cystic. After morphological analysis, duct measurements (length and diameter) were continued using a digital caliper. The data obtained were tabulated in SPSS 21 program, performing descriptive analysis with mean and standard deviation. The averages of bile ducts were 61.05 (± 16.43) mm in length and 3.86 (± 0.72) mm in diameter. The cystic duct length and diameter averages were 33.59 (± 12.29) mm and 3.40 (± 0.79) mm, respectively. The common hepatic ducts had an average of 30.02 (± 7.19) mm in length and 3.74 (± 1.18) mm in diameter. The analyzed samples presented different values ?? from those already described in the literature, where the length of the cystic ducts was greater, while the length of the common hepatic ducts was numerically smaller. This work is very significant, as the morphometric variability of the bile ducts allows for varying morphological situations that can compromise the hepatobiliar physiology.

RESUMEN: Los eventos adversos (EA) contribuyen significativamente a las morbilidades y comorbilidades postoperatorias. Muchos EA se deben a la falta de conocimiento de la anatomía y sus variaciones. Por ejemplo, las lesiones iatrogénicas de las vías biliares representan una complicación quirúrgica grave de la colecistectomía laparoscópica. El conocimiento anatómico para la identificación y drenaje adecuado de todos los conductos es relevante y fundamental para evitar futuros errores. El objetivo del estudio fue analizar morfométricamente las vías biliares en cadáveres humanos adultos. Se extrajeron 13 hígados de cadáveres humanos adultos y se retiraron los conductos: colédoco, hepático común y cístico. Después del análisis morfológico, se continuó con las mediciones de los conductos (longitud y diámetro) utilizando un calibrador digital. Los datos fueron tabulados en el programa SPSS 21, mediante análisis descriptivos con media y desviación estándar. Los promedios de las vías biliares fueron de 61,05 (± 16,43) mm de longitud y 3,86 (± 0,72) mm de diámetro. Los promedios de longitud y diámetro del conducto cístico fueron 33,59 (± 12,29) mm y 3,40 (± 0,79) mm, respectivamente. Los conductos hepáticos comunes tenían un promedio de 30,02 (± 7,19) mm de longitud y 3,74 (± 1,18) mm de diámetro. Las muestras analizadas presentaron valores diferentes a los ya descritos en la literatura, donde la longitud de los conductos císticos era mayor, mientras que la longitud de los conductos hepáticos comunes fue numéricamente menor. Este trabajo es significativo, debido a que la variabilidad morfométrica de las vías biliares y permite identificar situaciones morfológicas que pueden comprometer la fisiología hapatobiliar.

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11.

Endoparasite diversity and liver alterations in Hoplerythrinus unitaeniatus and Cichlasoma bimaculatum in a quilombola area in Maranhão, Brazil
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Silva, Ladilson Rodrigues

; Monteiro, Vitorya Mendes da Silva

; Paiva, Izabela Alves

; Mendes, Juliany Silva

; Jesus, Greiciene dos Santos de

; Silva, Marcelo Victor Rodrigues da

; Bezerra, Danilo Cutrim

; Carreiro, Carlos Riedel Porto

; Ribeiro, Larissa Sarmento dos Santos

; Coimbra, Viviane Correa Silva

; Bezerra, Nancyleni Pinto Chaves

Revista Brasileira de Parasitologia Veterinária

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2022, Volume 31 N. 2 elocation e000922

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Objetivou-se avaliar a diversidade de endoparasitos e alterações hepáticas em Hoplerythrinus unitaeniatus (jeju) e Cichlasoma bimaculatum (acará preto) de área quilombola maranhense, Brasil. Assim, 21 H. unitaeniatus e 21 C. bimaculatum foram capturados de ambiente alagável e transportados vivos ao laboratório. Após a eutanásia, procedeu-se à coleta, identificação de endoparasitos e avaliação de alterações hepáticas por meio de análise histológica, baseada na severidade das lesões: (i) alterações de estágio I, não comprometem o funcionamento dos órgãos; (ii) estágio II, lesões mais severas que prejudicam o funcionamento normal dos órgãos; (iii) estágio III, lesões muito severas e irreversíveis. Dos peixes avaliados, 71,43% H. unitaeniatus e 61,90% C. bimaculatum estavam parasitados. Contracaecum sp. foi encontrado nas duas espécies e acantocéfalos apenas em H. unitaeniatus. As alterações hepáticas foram vacuolização, núcleo na periferia das células, deformação do contorno celular, centro de melanomacrófagos, hiperemia, degeneração citoplasmática e vacuolização nuclear. Com o cálculo do índice das alterações, constatou-se que 26,19% dos exemplares apresentaram alterações de estágio I; 38,09% de estágio II e 9,52% de estágio III com a constatação de larvas de Contracaecum sp. encistadas no fígado. Conclui-se que existe alta prevalência de Contracaecum sp., e lesões hepáticas podem ser respostas adaptativas dos peixes à infecção endoparasitária.

Abstract Our aim was to assess endoparasite diversity and liver alterations in Hoplerythrinus unitaeniatus (jeju) and Cichlasoma bimaculatum (acará preto) in a quilombola area in Maranhão, Brazil. For this, 21 H. unitaeniatus and 21 C. bimaculatum were caught in a natural environment and transported to a laboratory. After these had been euthanized, endoparasites were collected and identified. Liver alterations were evaluated histological analysis based on the severity of each lesion: stage I, organ functioning not compromised; stage II, more severe lesions that impair normal functioning of the organs; and stage III, very severe and irreversible lesions. Among the fish evaluated, 71.43% H. unitaeniatus and 61.90% C. bimaculatum were parasitized. Contracaecum sp. was found in both species; while acanthocephalans, only in H. unitaeniatus. The alterations were vacuolization, nucleus in the cell periphery, deformation of the cell outline, melanomacrophage center, hyperemia, cytoplasmic degeneration and nuclear vacuolization. Through calculating a histological alteration index, it was found that 26.19% of the specimens presented lesions in stage I; 38.09% lesions in stage II and 9.52% lesions in stage III. It was concluded that there is high prevalence of Contracaecum sp. and that the liver lesions may be adaptive responses by the fish to endoparasitic infection.

https://doi.org/10.1590/s1984-29612022022

12.

Minimally invasive swine spine surgery training: technical aspects, benefits, and anatomical limitations
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Gotfryd, Alberto Ofenhejm

; Paula, Fábio Chaud de

; Sauma, Marcel Lobato

; Iutaka, Alexandre Sadao

; Rodrigues, Luciano Miller Reis

; Meyer, Guilherme Pereira Correa

; Teivelis, Marcelo Passos

; Poetscher, Arthur Werner

; Del Curto, David

; Kang, Davi Wen Wei

; Cintra, Luciana

; Gregores, Guilherme Buzon

; Lenza, Mario

; Ferretti, Mario

einstein (São Paulo)

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2022, Volume 20 elocation eAO6318

Abstract: En | Text: En | PDF: En

ABSTRACT Objective To describe the technical specificities and feasibility of simulation of minimally invasive spine surgery in live pigs, as well as similarities and differences in comparison to surgery in humans. Methods A total of 22 Large White class swine models, weighing between 60 and 80kg, were submitted to surgical simulations, performed during theoretical-practical courses for training surgical techniques (microsurgical and endoscopic lumbar decompression; percutaneous pedicular instrumentation; lateral access to the thoracic spine, and anterior and retroperitoneal to the lumbar spine, and management of complications) by 86 spine surgeons. For each surgical technique, porcine anatomy (similarities and differences in relation to human anatomy), access route, and dimensions of the instruments and implants used were evaluated. Thus, the authors describe the feasibility of each operative simulation, as well as suggestions to optimize training. Study results are descriptive, with figures and drawings. Results Neural decompression surgeries (microsurgeries and endoscopic) and pedicular instrumentation presented higher similarities to surgery on humans. On the other hand, intradiscal procedures had limitations due to the narrow disc space in swines. We were able to simulate situations of surgical trauma in surgical complication scenarios, such as cerebrospinal fluid fistulas and excessive bleeding, with comparable realism to surgery on humans. Conclusion A porcine model for simulation of minimally invasive spinal surgical techniques had similarities with surgery on humans, and is therefore feasible for surgeon training.

https://doi.org/10.31744/einstein_journal/2022ao6318

13.

CLINICAL AND FUNCTIONAL ANALYSIS AFTER TOTAL KNEE ARTHROPLASTY
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Araujo, Helder Rocha da Silva

; Heyn, Renan Simoes

; Torres, Marcelo Rodrigues

; Paranhos Junior, Halley

; Silva Junior, Ulbiramar Correa da

; Oliveira, Enio Chaves

Acta Ortopédica Brasileira

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2022, Volume 30 N. 3 elocation e247855

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO A Osteoartrite é uma das principais causas de incapacidade mundial. Objetivo: Avaliar os efeitos da Artroplastia Total de Joelho (ATJ) de sujeitos com osteoartrite de joelho com o Índice de Osteoartrite WOMAC (Western Ontario and McMaster Universities). Métodos: Estudo prospectivo não randomizado, com amostragem de conveniência. Foram incluídos sujeitos com diagnóstico de osteoartrite de joelho com indicação de tratamento cirúrgico. Foi utilizado o WOMAC para avaliar o nível de dor, rigidez articular, atividade física e qualidade de vida na fase pré-operatória e no pós-operatório com seis meses após a realização da cirurgia (unilateral). O WOMAC foi comparado aos fatores idade, sexo, Índice de Massa Corpórea (IMC) e o tipo de deformidade angular do joelho. Resultados: Foram analisados 58 pacientes, observou-se melhoras significantes na dor, rigidez articular, nível de atividade física e qualidade de vida, seis meses após a artroplastia total de joelho de acordo com o WOMAC. Conclusão: A ATJ apresentou efeitos positivos na qualidade de vida dos pacientes com osteoartrite de joelho. Nível de Evidência II, Estudo de Coorte.

ABSTRACT Osteoarthritis is a major cause of disability worldwide. Objective: To evaluate the effects of Total Knee Arthroplasty of subjects with knee osteoarthritis by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC ). Methods: Prospective, non-randomized study with convenience sampling. We included subjects with knee osteoarthritis with indication for surgical treatment. We used WOMAC to evaluate the level of pain, joint stiffness, physical activity, and quality of life in the preoperative and postoperative phase six months after unilateral surgery. We compared WOMAC to the factors age, gender, Body Mass Index and the type of angular deformity of the knee. Results: In total, we analyzed 58 patients with significant improvements in pain relief, joint stiffness, level of physical activity, and quality of life six months after total knee arthroplasty according to WOMAC. Conclusion: Total knee arthroplasty showed positive effects on the quality of life of patients with knee osteoarthritis. Level of Evidence II, Cohort Study.

https://doi.org/10.1590/1413-785220223003e247855

14.

PET/CT and inflammatory mediators in systemic sclerosis-associated interstitial lung disease
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Bastos, Andréa L

; Ferreira, Gilda A

; Mamede, Marcelo

; Mancuzo, Eliane V

; Teixeira, Mauro M

; Santos, Flávia P S T

; Ferreira, Cid S

; Correa, Ricardo A

Jornal Brasileiro de Pneumologia

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2022, Volume 48 N. 4 elocation e20210329

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Investigar a correlação entre achados de TCAR e a atividade metabólica pulmonar nas regiões correspondentes por meio de PET/TC com 18F-FDG e marcadores inflamatórios em pacientes com doença pulmonar intersticial (DPI) associada à esclerose sistêmica (ES). Métodos: Estudo transversal envolvendo 23 pacientes adultos com DPI associada à ES sem outras doenças do tecido conjuntivo. O estudo também envolveu PET/TC com 18F-FDG, TCAR, dosagem sérica de quimiocinas, dados clínicos e testes de função pulmonar. Resultados: Nessa coorte de pacientes com doença de longa duração (11,8 ± 8,7 anos), 19 (82,6%) apresentaram o padrão de pneumonia intersticial não específica. A mediana dos valores padronizados de captação foi maior nas áreas de faveolamento (1,95; p = 0,85). Os níveis séricos de soluble tumor necrosis factor receptor 1, soluble tumor necrosis factor receptor 2, C-C motif chemokine ligand 2 (CCL2) e C-X-C motif chemokine ligand 10 foram maiores nos pacientes com ES que nos controles. Os níveis séricos de CCL2 - um marcador de atividade fibroblástica - correlacionaram-se com áreas de opacidade em vidro fosco (OVF) pura na TCAR (p = 0,007). A PET/TC com 18F-FDG mostrou atividade metabólica significativa para todos os padrões de TCAR. A correlação entre níveis séricos de CCL2 e OVF na TCAR sugere que os fibroblastos desempenham um papel fundamental nessas áreas, acrescentando novas informações para a compreensão dos mecanismos que envolvem elementos celulares e moleculares e sua expressão na TCAR em pacientes com DPI associada à ES. Conclusões: A PET/TC com 18F-FDG aparentemente não consegue diferenciar a intensidade da atividade metabólica nos diferentes padrões de TCAR em pacientes com ES crônica. A associação entre CCL2 e OVF pode estar relacionada à atividade fibroblástica nessas áreas; entretanto, a expressão suprarregulada de CCL2 no tecido pulmonar de pacientes com ES deve ser investigada para que se compreenda melhor essa associação.

ABSTRACT Objective: To investigate the correlation of HRCT findings with pulmonary metabolic activity in the corresponding regions using 18F-FDG PET/CT and inflammatory markers in patients with systemic sclerosis (SSc)-associated interstitial lung disease (ILD). Methods: This was a cross-sectional study involving 23 adult patients with SSc-associated ILD without other connective tissue diseases. The study also involved 18F-FDG PET/CT, HRCT, determination of serum chemokine levels, clinical data, and pulmonary function testing. Results: In this cohort of patients with long-term disease (disease duration, 11.8 ± 8.7 years), a nonspecific interstitial pneumonia pattern was found in 19 (82.6%). Honeycombing areas had higher median standardized uptake values (1.95; p = 0.85). Serum levels of soluble tumor necrosis factor receptor 1, soluble tumor necrosis factor receptor 2, C-C motif chemokine ligand 2 (CCL2), and C-X-C motif chemokine ligand 10 were higher in SSc patients than in controls. Serum levels of CCL2-a marker of fibroblast activity-were correlated with pure ground-glass opacity (GGO) areas on HRCT scans (p = 0.007). 18F-FDG PET/CT showed significant metabolic activity for all HRCT patterns. The correlation between serum CCL2 levels and GGO on HRCT scans suggests a central role of fibroblasts in these areas, adding new information towards the understanding of the mechanisms surrounding cellular and molecular elements and their expression on HRCT scans in patients with SSc-associated ILD. Conclusions: 18F-FDG PET/CT appears to be unable to differentiate the intensity of metabolic activity across HRCT patterns in chronic SSc patients. The association between CCL2 and GGO might be related to fibroblast activity in these areas; however, upregulated CCL2 expression in the lung tissue of SSc patients should be investigated in order to gain a better understanding of this association.

https://doi.org/10.36416/1806-3756/e20210329

15.

Leaf extract of Coffea arabica L. reduces lipid peroxidation and has anti-platelet effect in a rat dyslipidemia model
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Simões, Mario Henrique Souza

; Salles, Bruno Cesar Correa

; Duarte, Stella Maris da Silveira

; Silva, Marcelo Aparecido da

; Viana, André Luiz Machado

; Moraes, Gabriel de Oliveira Isaac de

; Figueiredo, Sonia Aparecida

; Ferreira, Eric Batista

; Rodrigues, Maria Rita

; Paula, Fernanda Borges de Araújo

Brazilian Journal of Pharmaceutical Sciences

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2022, Volume 58 elocation e19562

Abstract: En | Text: En | PDF: En

Abstract This study aimed to evaluate the antioxidant potential of the Coffea arabica Lineu (L.) leaf extract and its effects on platelet aggregation of dyslipidemic rats. The extract was obtained by the percolation of C. arabica L. leaves in hydroethanolic solution 70% (v/v). The mass spectrometry FIA-ESI-MS² suggested the presence of chlorogenic acid, rutin acid, and quinic acid. The DPPH• radicals scavenging capacity was demonstrated (IC50 = 0.06 mg/mL). The extract was administered to rats by gavage (300 mg/kg/day) for 56 days. Dyslipidemia was induced by administering Triton WR-1339 (300 mg/kg body weight) on the 54th day. On day 56, blood was collected by puncturing the abdominal aorta artery and the aortic artery was removed. Lipid profile, markers of renal and hepatic injury, lipid peroxidation, and platelet aggregation tests were carried out. The ingestion of extract reduced the lipid peroxidation (aorta and plasma) and platelet aggregation in dyslipidemic rats. The extract did not affect markers of renal and hepatic function as analyzed in this study, suggesting neither impaired liver nor kidney function in these animals. Therefore, our results demonstrate that the extract of leaves of C. arabica L. show antioxidant potential in vitro and in vivo as well as anti-platelet aggregation in dyslipidemic animals.

https://doi.org/10.1590/s2175-97902022e19562

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