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Abstract Objective To evaluate clinical characteristics and outcomes of COVID-19 patients infected with HIV, and to compare with a paired sample without HIV infection. Methods This is a substudy of a Brazilian multicentric cohort that comprised two periods (2020 and 2021). Data was obtained through the retrospective review of medical records. Primary outcomes were admission to the intensive care unit, invasive mechanical ventilation, and death. Patients with HIV and controls were matched for age, sex, number of comorbidities, and hospital of origin using the technique of propensity score matching (up to 4:1). They were compared using the Chi-Square or Fisher's Exact tests for categorical variables and the Wilcoxon for numerical variables. Results Throughout the study, 17,101 COVID-19 patients were hospitalized, and 130 (0.76%) of those were infected with HIV. The median age was 54 (IQR: 43.0;64.0) years in 2020 and 53 (IQR: 46.0;63.5) years in 2021, with a predominance of females in both periods. People Living with HIV (PLHIV) and their controls showed similar prevalence for admission to the ICU and invasive mechanical ventilation requirement in the two periods, with no significant differences. In 2020, in-hospital mortality was higher in the PLHIV compared to the controls (27.9% vs. 17.7%; p = 0.049), but there was no difference in mortality between groups in 2021 (25.0% vs. 25.1%; p > 0.999). Conclusions Our results reiterate that PLHIV were at higher risk of COVID-19 mortality in the early stages of the pandemic, however, this finding did not sustain in 2021, when the mortality rate is similar to the control group.

https://doi.org/10.1016/j.clinsp.2023.100223

The influence of sensory attributes on overall liking by a gamma regression model: an analysis of Cerrado mixed fruits jams
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PEREIRA, Patrícia Aparecida Pimenta

; SOUZA, Vanessa Rios de

; SCHIASSI, Maria Cecília Evangelista Vasconcelos

; DIAS, Ana Clara Costa

; QUEIROZ, Fabiana

; PINHEIRO, Ana Carla Marques

; BORGES, Soraia Vilela

; CIRILLO, Marcelo Ângelo

Food Science and Technology

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sep 2021, Volume 41 N. 3 Pages 702 - 707

Abstract: En | Text: En | PDF: En

Abstract Factors that influence the acceptability and preferences of consumers have been perceived as sensory attributes, such as color, appearance, flavor, and texture. Understanding which attributes are most important for overall liking would be helpful to establish meaningful criteria for product grading. Thus, in addition to the overall chemical and sensory qualities, it is important to appreciate which sensory attributes make a product pleasant or unpleasant to a consumer. In this context, the aim of this study was to evaluate the sensory attribute that contributes most to the overall liking by a gamma regression model using different formulations of mixed fruit jams made with Brazilian Cerrado fruits. Based on the proposed model, we concluded that appearance was the most important predictor of the overall liking of the assessors.

https://doi.org/10.1590/fst.17920 135 downloads

COVID-19: The question of genetic diversity and therapeutic intervention approaches
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Figueiredo, David Livingstone Alves

; Ximenez, João Paulo Bianchi

; Seiva, Fábio Rodrigues Ferreira

; Panis, Carolina

; Bezerra, Rafael dos Santos

; Ferrasa, Adriano

; Cecchini, Alessandra Lourenço

; Medeiros, Alexandra Ivo de

; Almeida, Ana Marisa Fusco

; Ramão, Anelisa

; Boldt, Angelica Beate Winter

; Moya, Carla Fredrichsen

; Chin, Chung Man

; Paula, Daniel de

; Rech, Daniel

; Gradia, Daniela Fiori

; Malheiros, Danielle

; Venturini, Danielle

; Tavares, Eliandro Reis

; Carraro, Emerson

; Ribeiro, Enilze Maria de Souza Fonseca

; Pereira, Evani Marques

; Tuon, Felipe Francisco

; Follador, Franciele Aní Caovilla

; Fernandes, Glaura Scantamburlo Alves

; Volpato, Hélito

; Cólus, Ilce Mara de Syllos

; Oliveira, Jaqueline Carvalho de

; Rodrigues, Jean Henrique da Silva

; Santos, Jean Leandro dos

; Visentainer, Jeane Eliete Laguila

; Brandi, Juliana Cristina

; Serpeloni, Juliana Mara

; Bonini, Juliana Sartori

; Oliveira, Karen Brajão de

; Fiorentin, Karine

; Lucio, Léia Carolina

; Faccin-Galhardi, Ligia Carla

; Ferreto, Lirane Elize Defante

; Lioni, Lucy Megumi Yamauchi

; Consolaro, Marcia Edilaine Lopes

; Vicari, Marcelo Ricardo

; Arbex, Marcos Abdo

; Pileggi, Marcos

; Watanabe, Maria Angelica Ehara

; Costa, Maria Antônia Ramos

; Giannini, Maria José S. Mendes

; Amarante, Marla Karine

; Khalil, Najeh Maissar

; Lima Neto, Quirino Alves de

; Herai, Roberto H.

; Guembarovski, Roberta Losi

; Shinsato, Rogério N.

; Mainardes, Rubiana Mara

; Giuliatti, Silvana

; Yamada-Ogatta, Sueli Fumie

; Gerber, Viviane Knuppel de Quadros

; Pavanelli, Wander Rogério

; Silva, Weber Claudio da

; Petzl-Erler, Maria Luiza

; Valente, Valeria

; Soares, Christiane Pienna

; Cavalli, Luciane Regina

; Silva Jr, Wilson Araujo

Genetics and Molecular Biology

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2021, Volume 44 N. 1 elocation e20200452

Abstract: En | Text: En | PDF: En

Abstract Coronavirus disease 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus type 2 (SARS-CoV-2), is the largest pandemic in modern history with very high infection rates and considerable mortality. The disease, which emerged in China’s Wuhan province, had its first reported case on December 29, 2019, and spread rapidly worldwide. On March 11, 2020, the World Health Organization (WHO) declared the COVID-19 outbreak a pandemic and global health emergency. Since the outbreak, efforts to develop COVID-19 vaccines, engineer new drugs, and evaluate existing ones for drug repurposing have been intensively undertaken to find ways to control this pandemic. COVID-19 therapeutic strategies aim to impair molecular pathways involved in the virus entrance and replication or interfere in the patients’ overreaction and immunopathology. Moreover, nanotechnology could be an approach to boost the activity of new drugs. Several COVID-19 vaccine candidates have received emergency-use or full authorization in one or more countries, and others are being developed and tested. This review assesses the different strategies currently proposed to control COVID-19 and the issues or limitations imposed on some approaches by the human and viral genetic variability.

https://doi.org/10.1590/1678-4685-gmb-2020-0452

A high prevalence of human papillomavirus 16 and 18 co-infections in cervical biopsies from southern Brazil
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Jesus, Sheile Pinheiro de

; Costa, Ana Carla Marques da

; Barcellos, Regina Bones

; Medeiros, Rubia Marília de

; Silva, Cláudia Maria Dornelles da

; Rossetti, Maria Lucia

Brazilian Journal of Microbiology

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2018, Volume 49 Suppl. 1 Pages 220 - 223

Abstract: En | Text: En | PDF: En

ABSTRACT HPV types 16 and 18 were studied in paraffin-fixed cervical biopsy collected in southern Brazil. HPV 16, HPV 18 and co-infection HPV 16/18 were identified in 10/57 (17.5%), 4/57 (7%) and in 43/57 (75.4%) samples, respectively. Southern Brazil has one of the highest prevalence rates of HPV 16/18 reported.

https://doi.org/10.1016/j.bjm.2018.04.003 879 downloads

Integrative and complementary practices: use by community health agents in self-care
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Lima, Cássio de Almeida

; Santos, Ana Maria Vitrícia de Souza

; Messias, Romerson Brito

; Costa, Fernanda Marques da

; Barbosa, Dulce Aparecida

; Silva, Carla Silvana de Oliveira e

; Pinho, Lucinéia de

; Brito, Maria Fernanda Santos Figueiredo

Revista Brasileira de Enfermagem

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2018, Volume 71 Suppl. 6 Pages 2682 - 2688

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

ABSTRACT Objective: To verify the use of integrative and complementary practices (ICPs) by community health agents working in family health teams. Methods: Cross-sectional, quantitative research, conducted in the city of Montes Claros, Minas Gerais. An structured form was used for the characterization of participants and use of ICPs. Descriptive and bivariate analyses were conducted. Results: Use of ICPs was referenced by 94 (40.7%) agents. The use of medicinal plants was predominant (32.5%). There were associations between: ICPs in general and negative self-perception of health (p=0.032), homeopathy and higher education (p=0.015), massage and living with partner(p=0.024), chiropractic care and income equal to or greater than four minimum wages (p=0.031), relaxation/meditation and religion (p=0.028). Conclusion: The use of ICPs was verified in the healthcare of community agents. It is necessary to strengthen these practices for the promotion of health and prevention of diseases.

RESUMEN Objetivo: Verificar la utilización de prácticas integradoras y complementarias (PICs) por agentes comunitarios de salud actuantes en los equipos de salud de la familia. Método: Investigación transversal, cuantitativa, realizada en la ciudad de Montes Claros, Minas Gerais. Se utilizó formulario estructurado para caracterización de los participantes y del uso de las PICs. Se realizaron análisis descriptivos y bivariados. Resultados: La utilización de las PICs fue referida por 94 (40,7%) de los agentes. Predominó el uso de las plantas medicinales (32,5%). Hubo asociaciones entre: las PICs en general y la autopercepción negativa para la salud (p=0,032), la homeopatía y la educación superior (p=0,015), el masaje y la vida en pareja (p=0,024), la quiropraxia y el ingreso igual o menor que cuatro salarios mínimos (p=0,031), la relajación/meditación y tener una religión (p=0,028). Conclusión: El uso de las PICs fue verificado en el cuidado en salud de los agentes comunitarios. Es necesario reforzar estas prácticas para la promoción de la salud y prevención de enfermedades.

RESUMO Objetivo: Verificar a utilização de práticas integrativas e complementares (PICs) por agentes comunitários de saúde atuantes nas equipes de saúde da família. Método: Pesquisa transversal, quantitativa, realizada na cidade de Montes Claros, Minas Gerais. Utilizou-se formulário estruturado para caracterização dos participantes e do uso de PICs. Foram conduzidas análises descritiva e bivariada. Resultados: A utilização de PICs foi referida por 94 (40,7%) dos agentes. Predominou o uso de plantas medicinais (32,5%). Houve associações entre: PICs no geral e autopercepção negativa da saúde (p=0,032), homeopatia e ensino superior (p=0,015), massagem e viver com companheiro (p=0,024), quiropraxia e renda igual ou superior a quatro salários mínimos (p=0,031), relaxamento/meditação e ter religião (p=0,028). Conclusão: O uso de PICs foi verificado no cuidado em saúde dos agentes comunitários. É preciso fortalecer essas práticas para a promoção da saúde e prevenção de agravos.

https://doi.org/10.1590/0034-7167-2018-0078 2 downloads

Integrative and complementary practices: use by community health agents in self-care
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Lima, Cássio de Almeida

; Santos, Ana Maria Vitrícia de Souza

; Messias, Romerson Brito

; Costa, Fernanda Marques da

; Barbosa, Dulce Aparecida

; Silva, Carla Silvana de Oliveira e

; Pinho, Lucinéia de

; Brito, Maria Fernanda Santos Figueiredo

Revista Brasileira de Enfermagem

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2018, Volume 71 Suppl. 6 Pages 2682 - 2688

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

https://doi.org/10.1590/0034-7167-2018-0078 5268 downloads

Período puerperal: a importância da visita domiciliar para enfermeiros da Atenção Primária à Saúde
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Medeiros, Leticia dos Santos

; Costa, Ana Carla Marques da

Rev Rene

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feb 2016, Volume 17 N. 1 Pages 112 - 119

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Objective to understand the importance given by nurses working in primary health care for the realization of home visits in the puerperal period. Methods qualitative research held with 38 nurses by applying a semi-structured interview, in which the thematic content analysis technique was used under Bardin’s theoretical light. Results the majority of interviewees considered the home visit a tool that brings the health unit to the reality experienced by the mother, however, there are still many professionals who omit some precautions when dealing with this population. Conclusion the home visit is considered essential for contributing to the reduction of morbidity and mortality of the postpartum and newborn, increasing the bond between unit and family, and reducing the risk of postpartum complications, however, the attention turned to these women is still covered with big challenges to achieve a real satisfactory assistance.

Objetivo compreender a importância dada pelos enfermeiros atuantes na Atenção Primária à Saúde para realização da visita domiciliar no período puerperal. Métodos pesquisa qualitativa, realizada com 38 enfermeiros através da aplicação de uma entrevista semiestruturada, na qual utilizou-se a técnica da análise de conteúdo temática a luz teórica de Bardin. Resultados a maioria dos entrevistados consideram a visita domiciliar, uma ferramenta que aproxima a unidade de saúde da realidade vivenciada pela puérpera, porém, ainda são muitos os profissionais que omitem certos cuidados frente a esta população. Conclusão a visita domiciliar é considerada imprescindível, por contribuir para a redução da morbimortalidade da puérpera e recém-nascido, aumentar o vínculo entre unidade e família, e diminuir riscos de complicações pós-parto, no entanto, a atenção voltada a estas mulheres ainda está recoberta de grandes desafios para alcançar uma assistência de fato satisfatória.

https://doi.org/10.15253/2175-6783.2016000100015 4 downloads

Heating on the volatile composition and sensory aspects of extra-virgin olive oil
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Nunes, Cleiton Antônio

; Souza, Vanessa Rios de

; Corrêa, Síntia Carla

; Silva, Marília de Cássia da Costa e

; Bastos, Sabrina Carvalho

; Pinheiro, Ana Carla Marques

Ciência e Agrotecnologia

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dec 2013, Volume 37 N. 6 Pages 566 - 572

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Os principais meios de consumo do azeite de oliva extravirgem incluem a aplicação direta em saladas ou como ingrediente em molhos, mas ele também tem sido usado para cozinhar, seja em frituras ou cozimentos. No entanto, sob estresse térmico, alguns componentes não-glicerídicos do azeite podem ser degradados. Assim, o efeito do aquecimento (a 50, 100, 150 e 200 °C por 2 h) sobre os componentes voláteis e aspectos sensoriais do azeite de oliva extravirgem foram avaliados. Os resultados indicaram que o aquecimento alterou a composição volátil do azeite extra virgem, principalmente em temperaturas mais elevadas (acima de 150 °C). As principais modificações foram relacionadas à formação de compostos oxidados, sobretudo aldeídos de cadeia longa. Os aspectos sensoriais também sofreram alterações quando o azeite foi aquecido a temperaturas elevadas (acima de 150 °C), o que pode ter sido influenciado por alterações de cor e pelas da composição volátil do produto.

The main ways by which extra-virgin olive oil is consumed include direct application on salads or as an ingredient in sauces, but it is also been used by some for cooking, including frying and baking. However, it has been reported that under heat stress, some nonglyceridic components of olive oil are degraded. So, the effect of heating (at 50, 100, 150, and 200 °C for 2 h) on the volatile composition and sensory aspects of extra-virgin olive oil were evaluated. Heating altered the volatile composition of extra-virgin olive oil, mainly at higher temperatures (above 150 °C). The main modifications were related to the formation of large amounts of oxidized compounds, particularly large chain aldehydes. Sensory aspects were also altered when the oil was heated to higher temperatures, which might have occurred because of color alterations and mainly changes in the volatile composition of the oil.

6906 downloads Cited 1 time in SciELO

Avaliação da qualidade do abacaxi "Pérola" minimamente processado armazenado sob atmosfera modificada
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Santos, Juliana Costa Bueno

; Vilas Boas, Eduardo Valério de Barros

; Prado, Mônica Elisabeth Torres

; Pinheiro, Ana Carla Marques

Ciência e Agrotecnologia

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apr 2005, Volume 29 N. 2 Pages 353 - 361

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Objetivou-se com este trabalho verificar o efeito da atmosfera modificada ativa sobre a qualidade do abacaxi minimamente processado. Assim, foram avaliadas as modificações físico-químicas, sensorial e microbiológica do abacaxi 'Pérola' minimamente processado submetido a diferentes atmosferas modificadas passiva e ativamente (controle - atmosfera modificada passiva; 5%O2 + 5%CO2 , 2%O2 + 10%CO2). A atmosfera com 2% O2 + 10% CO2 determinou menor perda de líquido drenado, embora tal perda tenha sido desprezível. A atmosfera modificada ativa preveniu o amaciamento do abacaxi minimamente processado, reduzindo a atividade da poligalacturonase e solubilização péctica. As variáveis pH e vitamina C não foram significativamente afetadas pela atmosfera modificada ativa. Maiores valores de sólidos solúveis totais (SST) foram encontrados nos frutos sob atmosfera 5% O2 + 5% CO2 e no caso dos açúcares solúveis o tratamento com 2% O2 + 10% CO2 resultou em maiores teores. De acordo com análise sensorial, os frutos sob atmosfera modificada passiva se sobressaíram com relação ao sabor, aparência e cor. A análise microbiológica detectou valores insignificantes para fungos filamentosos, leveduras e coliformes a 35° e 45°C em todos os tratamentos. Conclui-se que o abacaxi 'Pérola' minimamente processado pode ser armazenado por 8 dias, a 5°C, sob atmosfera modificada passiva.

The goal of this work was to verify the effect of active modified atmosphere on the quality of fresh-cut pineapple. Physical-chemical, sensory and microbiological changes of fresh-cut 'Pérola' pineapple treated with passive (control) and active (5%O2 + 5%CO2; 2%O2 + 10%CO2) modified atmosphere were studied. The 2%O2 + 10%CO2 combination promoted the lowest loss of drained liquid, although they were negligible. Active modified atmosphere prevented the softening of fresh cut pineapples, reducing the poligalacturonase activity and pectin solubilization. The pH and ascorbic acid were not significantly affected by active modified atmosphere. Higher values of total soluble solids (TSS) were found in the slices under 5%O2 + 5%CO2, whereas 2%O2 + 10%CO2 promoted higher levels of total sugars. According to sensory evaluation, slices under passive modified atmosphere had better flavor, appearance and color. The microbiological analysis detected no significant values for fungus, yeasts and coliforms at 35°C and 45°C in all treatments. Fresh cut 'Pérola' pineapple can be stored for 8 days, at 5°C, under passive modified atmosphere.

4399 downloads Cited 2 times in SciELO

10.

Influência do CaCl2 sobre a qualidade pós-colheita do abacaxi cv. Pérola
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Pinheiro, Ana Carla Marques

; Vilas Boas, Eduardo Valério de Barros

; Lima, Luciana Costa

Food Science and Technology

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mar 2005, Volume 25 N. 1 Pages 32 - 36

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Objetivou-se avaliar a influência do cloreto de cálcio (CaCl2) sobre a qualidade pós-colheita de abacaxis cv. Pérola, armazenados sob condições simuladas de transporte marítimo (21 dias a 12±1ºC) e comercialização (8 dias a temperatura ambiente, 21 ± 1ºC). O experimento foi conduzido utilizando-se parcelas constituídas de 6 frutos, obedecendo um delineamento experimental inteiramente casualizado e constituindo um fatorial 4 x 6, com 3 repetições, tendo-se quatro níveis de cloreto de cálcio (0, 1, 2 e 3%) e seis épocas de análise (0, 21, 23, 25, 27 e 29 dias de armazenamento). Observou-se que a imersão em solução de cloreto de cálcio a 3% promoveu diminuição no índice de escurecimento interno, na área afetada e na intensidade do escurecimento interno, além de determinar uma maior perda de massa e diminuição aparente na solubilização de substâncias pécticas. O cloreto de cálcio, independente do nível, foi efetivo na manutenção da firmeza, embora não tenha afetado significativamente as variáveis pH, acidez titulável, açúcares solúveis totais e pectina total.

The goal of this work was to evaluate the influence of the calcium chloride (CaCl2) on the quality of 'Pérola' pineapples, stored under simulated conditions of sea transport (21 days at 12+ 1ºC) and marketing (8 days at room temperature, 21 + 1ºC). The experiment was carried out in a completely randomly design. A factorial 4 X 6 (4 levels of calcium chloride: 0, 1, 2 and 3% and six periods of analysis: 0, 21, 23, 25, 27 and 29 days of storage) with 3 replicates and six fruits per parcel. The immersion in solution of calcium chloride at 3% promoted decreasing apparent in internal breakdown index, affected area and intensity of internal breakdown, as well as promoted higher mass loss and decreasing in pectic substances solubilization. The calcium chloride, despite the level, was effective in maintaining the firmness, although have not affected significantly the variables, pH, titratable acidity, total soluble sugars and total pectin.

3028 downloads Cited 4 times in SciELO

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