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ABSTRACT Objective: To report outcomes from the largest multicenter series of penile cancer patients undergoing video endoscopic inguinal lymphadenectomy (VEIL). Materials and Methods: Retrospective multicenter analysis. Authors of 21 centers from the Penile Cancer Collaborative Coalition-Latin America (PeC-LA) were included. All centers performed the procedure following the same previously described standardized technique. Inclusion criteria included penile cancer patients with no palpable lymph nodes and intermediate/high-risk disease and those with non-fixed palpable lymph nodes less than 4 cm in diameter. Categorical variables are shown as percentages and frequencies whereas continuous variables as mean and range. Results: From 2006 to 2020, 210 VEIL procedures were performed in 105 patients. Mean age was 58 (45-68) years old. Mean operative time was 90 minutes (60-120). Mean lymph node yield was 10 nodes (6-16). Complication rate was 15.7%, including severe complications in 1.9% of procedures. Lymphatic and skin complications were noted in 8.6 and 4.8% of patients, respectively. Histopathological analysis revealed lymph node involvement in 26.7% of patients with non-palpable nodes. Inguinal recurrence was observed in 2.8% of patients. 10y- overall survival was 74.2% and 10-y cancer specific survival was 84.8%. CSS for pN0, pN1, pN2 and pN3 were 100%, 82.4%, 72.7% and 9.1%, respectively. Conclusion: VEIL seems to offer appropriate long term oncological control with minimal morbidity. In the absence of non-invasive stratification measures such as dynamic sentinel node biopsy, VEIL emerged as the alternative for the management of non-bulky lymph nodes in penile cancer.

https://doi.org/10.1590/s1677-5538.ibju.2023.0065

Production of pre-sprouted sugarcane seedlings using carnauba bagana as substrate
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Leite, Marcos Renan Lima

; Costa, Romário Martins

; Matos, Sâmia dos Santos

; Andrade, Hosana Aguiar Freitas de

; Silva-Matos, Raissa Rachel Salustriano da

Pesquisa Agropecuária Tropical

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2023, Volume 53 elocation e74082

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT Sugarcane seedling quality is strongly influenced by the substrate used. Currently, alternative substrate sources from the sugarcane industry itself have been used; however, there is no specific substrate to produce pre-sprouted seedlings. This study aimed to evaluate the quality of pre-sprouted sugarcane using substrates with different proportions of carnauba bagana (0, 20, 40, 60, 80 and 100 %) plus soil. The experimental design was completely randomized, with six treatments and five replicates. Pre-sprouted seedlings cultivated using substrate composed by 80 % of carnauba bagana showed the best response for number of leaves, diameter, shoot length, shoot, root and total dry mass, and Dickson Quality Index, owing to the improvement in the substrate physical and chemical characteristics.

RESUMO A qualidade de mudas de cana-de-açúcar é fortemente influenciada pelo substrato utilizado. Atualmente, fontes alternativas de substrato oriundas da própria indústria canavieira têm sido empregadas; no entanto, não existe substrato específico para produção de mudas pré-brotadas. Objetivou-se avaliar a qualidade de mudas pré-brotadas de cana-de-açúcar cultivadas em substratos com diferentes proporções de bagana de carnaúba (0, 20, 40, 60, 80 e 100 %) acrescida de solo. O delineamento experimental foi inteiramente casualizado, com seis tratamentos e cinco repetições. As mudas pré-brotadas cultivadas em substrato composto por 80 % de bagana de carnaúba obtiveram melhor resposta para número de folhas, diâmetro, comprimento do broto, massa seca da parte aérea, radicular e total, e Índice de Qualidade de Dickson, em decorrência da melhoria nas características físicas e químicas do substrato.

https://doi.org/10.1590/1983-40632023v5374082

[SciELO Preprints] - Guideline of the Brazilian Society of Cardiology on Diagnosis and Treatment of Patients with Chagas Disease Cardiomyopathy
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Marin-Neto, José Antonio Rassi Jr., Anis Moraes Oliveira, Gláucia M. Lemos Correia, Luís Claudio Novaes Ramos Jr., Alberto Hasslocher-Moreno, Alejandro Marcel Luquetti Ostermayer, Alejandro Sousa, Andréa Silvestre de Amato Vincenzo de Paola, Angelo Sobral de Sousa, Antonio Carlos Pinho Ribeiro, Antonio Luiz Correia Filho, Dalmo Moraes de Souza, Dilma do Socorro Cunha-Neto, Edecio J. A. Ramires, Felix Bacal, Fernando Pereira Nunes, Maria do Carmo Martinelli Filho, Martino Ibrahim Scanavacca, Maurício Magalhães Saraiva, Roberto Alves de Oliveira Júnior, Wilson M. Lorga-Filho, Adalberto de Jesus Benevides de Almeida Guimarães, Adriana Lopes Latado Braga, Adriana Sarmento de Oliveira, Adriana V. L. Sarabanda, Alvaro Yecê das Neves Pinto, Ana Assis Lopes do Carmo, André Schmidt, André Costa, Andréa Rodrigues da Ianni, Barbara Maria Markman Filho, Brivaldo Eduardo Rochitte, Carlos Thé Macedo, Carolina Mady, Charles Chevillard, Christophe Bittencourt das Virgens, Cláudio Marcelo Nery de Castro, Cleudson De Paoli de Carvalho Britto, Constança Felícia Pisani, Cristiano do Carmo Rassi, Daniela C. Sobral Filho, Dario Rodrigues Almeida, Dirceu A. Bocchi, Edimar T. Mesquita, Evandro de Souza Nogueira Sardinha Mendes, Fernanda Pereira, Francisca Tatiana Sperandio da Silva, Gilberto Marcelo de Lima Peixoto, Giselle Glotz de Lima, Gustavo H. Veloso, Henrique Turin Moreira, Henrique Bellotti Lopes, Hugo Masciarelli Francisco Pinto, Ibraim Pinto Dias, João Carlos Bemfica, João Marcos Silva-Nunes, João Paulo Soares Barreto-Filho, José Augusto Kerr Saraiva, José Francisco Lannes-Vieira, Joseli Menezes Oliveira, Joselina Luzia V. Armaganijan, Luciana Martins, Luiz Cláudio C. Sangenis, Luiz Henrique Barbosa, Marco Paulo Almeida-Santos, Marcos Antônio Simões, Marcos Vinicius Shikanai-Yasuda, Maria Aparecida Vieira Moreira, Maria da Consolação Higuchi, Maria de Lourdes Costa Monteiro, Maria Rita de Cássia Felix Mediano, Mauro Felippe Maia Lima, Mayara T. Oliveira, Maykon Moreira Dias Romano , Minna Nitz, Nadjar de Tarso Jorge Medeiros, Paulo Vieira Alves, Renato Alkmim Teixeira, Ricardo Coury Pedrosa, Roberto Aras, Roque Morais Torres, Rosália dos Santos Povoa, Rui Manoel Rassi, Sérgio Gabriel Salles Xavier, Sérgio Marinho Martins Alves , Silvia B. N. Tavares, Suelene Lima Palmeira, Swamy da Silva Junior, Telêmaco Luiz da Rocha Rodrigues, Thiago Madrini Junior, Vagner Maia da Costa , Veruska Dutra, Walderez

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Publication date: 2022-10-11

Abstract: En Pt

This guideline aimed to update the concepts and formulate the standards of conduct and scientific evidence that support them, regarding the diagnosis and treatment of the Cardiomyopathy of Chagas disease, with special emphasis on the rationality base that supported it.nbsp; Chagas disease in the 21st century maintains an epidemiological pattern of endemicity in 21 Latin American countries. Researchers and managers from endemic and non-endemic countries point to the need to adopt comprehensive public health policies to effectively control the interhuman transmission of T. cruzi infection, and to obtain an optimized level of care for already infected individuals, focusing on diagnostic and therapeutic opportunistic opportunities. nbsp; Pathogenic and pathophysiological mechanisms of the Cardiomyopathy of Chagas disease were revisited after in-depth updating and the notion that necrosis and fibrosis are stimulated by tissue parasitic persistence and adverse immune reaction, as fundamental mechanisms, assisted by autonomic and microvascular disorders, was well established. Some of them have recently formed potential targets of therapies.nbsp; The natural history of the acute and chronic phases was reviewed, with enhancement for oral transmission, indeterminate form and chronic syndromes. Recent meta-analyses of observational studies have estimated the risk of evolution from acute and indeterminate forms and mortality after chronic cardiomyopathy. Therapeutic approaches applicable to individuals with Indeterminate form of Chagas disease were specifically addressed. All methods to detect structural and/or functional alterations with various cardiac imaging techniques were also reviewed, with recommendations for use in various clinical scenarios. Mortality risk stratification based on the Rassi score, with recent studies of its application, was complemented by methods that detect myocardial fibrosis.nbsp; The current methodology for etiological diagnosis and the consequent implications of trypanonomic treatment deserved a comprehensive and in-depth approach. Also the treatment of patients at risk or with heart failure, arrhythmias and thromboembolic events, based on pharmacological and complementary resources, received special attention. Additional chapters supported the conducts applicable to several special contexts, including t. cruzi/HIV co-infection, risk during surgeries, in pregnant women, in the reactivation of infection after heart transplantation, and others.nbsp; nbsp;nbsp; Finally, two chapters of great social significance, addressing the structuring of specialized services to care for individuals with the Cardiomyopathy of Chagas disease, and reviewing the concepts of severe heart disease and its medical-labor implications completed this guideline.

Esta diretriz teve como objetivo principal atualizar os conceitos e formular as normas de conduta e evidências científicas que as suportam, quanto ao diagnóstico e tratamento da CDC, com especial ênfase na base de racionalidade que a embasou. A DC no século XXI mantém padrão epidemiológico de endemicidade em 21 países da América Latina. Investigadores e gestores de países endêmicos e não endêmicos indigitam a necessidade de se adotarem políticas abrangentes, de saúde pública, para controle eficaz da transmissão inter-humanos da infecção pelo T. cruzi, e obter-se nível otimizado de atendimento aos indivíduos já infectados, com foco em oportunização diagnóstica e terapêutica. Mecanismos patogênicos e fisiopatológicos da CDC foram revisitados após atualização aprofundada e ficou bem consolidada a noção de que necrose e fibrose sejam estimuladas pela persistência parasitária tissular e reação imune adversa, como mecanismos fundamentais, coadjuvados por distúrbios autonômicos e microvasculares. Alguns deles recentemente constituíram alvos potenciais de terapêuticas. A história natural das fases aguda e crônica foi revista, com realce para a transmissão oral, a forma indeterminada e as síndromes crônicas. Metanálises recentes de estudos observacionais estimaram o risco de evolução a partir das formas aguda e indeterminada e de mortalidade após instalação da cardiomiopatia crônica. Condutas terapêuticas aplicáveis aos indivíduos com a FIDC foram abordadas especificamente. Todos os métodos para detectar alterações estruturais e/ou funcionais com variadas técnicas de imageamento cardíaco também foram revisados, com recomendações de uso nos vários cenários clínicos. Estratificação de risco de mortalidade fundamentada no escore de Rassi, com estudos recentes de sua aplicação, foi complementada por métodos que detectam fibrose miocárdica. A metodologia atual para diagnóstico etiológico e as consequentes implicações do tratamento tripanossomicida mereceram enfoque abrangente e aprofundado. Também o tratamento de pacientes em risco ou com insuficiência cardíaca, arritmias e eventos tromboembólicos, baseado em recursos farmacológicos e complementares, recebeu especial atenção. Capítulos suplementares subsidiaram as condutas aplicáveis a diversos contextos especiais, entre eles o da co-infecção por T. cruzi/HIV, risco durante cirurgias, em grávidas, na reativação da infecção após transplante cardíacos, e outros.nbsp;nbsp;nbsp; Por fim, dois capítulos de grande significado social, abordando a estruturação de serviços especializados para atendimento aos indivíduos com a CDC, e revisando os conceitos de cardiopatia grave e suas implicações médico-trabalhistas completaram esta diretriz.nbsp;

https://doi.org/10.1590/SciELOPreprints.4820

Diretriz de Miocardites da Sociedade Brasileira de Cardiologia – 2022
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Montera, Marcelo Westerlund

; Marcondes-Braga, Fabiana G.

; Simões, Marcus Vinícius

; Moura, Lídia Ana Zytynski

; Fernandes, Fabio

; Mangine, Sandrigo

; Oliveira Júnior, Amarino Carvalho de

; Souza, Aurea Lucia Alves de Azevedo Grippa de

; Ianni, Bárbara Maria

; Rochitte, Carlos Eduardo

; Mesquita, Claudio Tinoco

; de Azevedo Filho, Clerio F.

; Freitas, Dhayn Cassi de Almeida

; Melo, Dirceu Thiago Pessoa de

; Bocchi, Edimar Alcides

; Horowitz, Estela Suzana Kleiman

; Mesquita, Evandro Tinoco

; Oliveira, Guilherme H.

; Villacorta, Humberto

; Rossi Neto, João Manoel

; Barbosa, João Marcos Bemfica

; Figueiredo Neto, José Albuquerque de

; Luiz, Louise Freire

; Hajjar, Ludhmila Abrahão

; Beck-da-Silva, Luis

; Campos, Luiz Antonio de Almeida

; Danzmann, Luiz Cláudio

; Bittencourt, Marcelo Imbroinise

; Garcia, Marcelo Iorio

; Avila, Monica Samuel

; Clausell, Nadine Oliveira

; Oliveira Jr, Nilson Araujo de

; Silvestre, Odilson Marcos

; Souza, Olga Ferreira de

; Mourilhe-Rocha, Ricardo

; Kalil Filho, Roberto

; Al-Kindi, Sadeer G.

; Rassi, Salvador

; Alves, Silvia Marinho Martins

; Ferreira, Silvia Moreira Ayub

; Rizk, Stéphanie Itala

; Mattos, Tiago Azevedo Costa

; Barzilai, Vitor

; Martins, Wolney de Andrade

; Schultheiss, Heinz-Peter

Arquivos Brasileiros de Cardiologia

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2022, Volume 119 N. 1 Pages 143 - 211

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20220412

Magnetic and Mesoporous Silica-Niobia Material as Modifier of Carbon Paste Electrode for p-Nitrophenol Electrochemical Determination
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Tkachenko, Oleg

; Rosa, Danielle S. da

; Virgili, Anike H.

; Vasconcellos, Marcos A. Z.

; Costa, Tania M. H.

; Arenas, Leliz T.

; Deon, Monique

; Benvenutti, Edilson V.

; Menezes, Eliana W. de

Journal of the Brazilian Chemical Society

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mar 2021, Volume 32 N. 3 Pages 609 - 617

Abstract: En | Text: En | PDF: En

In the present work, the sol-gel synthesis method was employed as strategy to obtain a magnetic and mesoporous silica-niobia material. The planned synthesis was based on the hetero-condensation of niobium and silicon alkoxide precursors, in the presence of spherical magnetite particles. The resulting material presented interesting characteristics such as magnetism, large mesopores, in the range from 20 to 50 nm, and 68 m2 g-1 of surface area. These features allowed its use as modifier of carbon paste electrode for p-nitrophenol determination, since niobia has never been used in electrochemical sensors for the determination of nitrophenol compounds. By using differential pulse voltammetry technique, the electrode can be applied in a wide range of p-nitrophenol concentration, from 10 to 490 μmol L-1, with a limit of detection of 1.2 µmol L-1 and sensitivity up to 0.60 µA L µmol-1. The proposed electrode presented good sensitivity and selectivity and it was applied in real water samples.

https://doi.org/10.21577/0103-5053.20200215 167 downloads

COVID-19: The question of genetic diversity and therapeutic intervention approaches
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Figueiredo, David Livingstone Alves

; Ximenez, João Paulo Bianchi

; Seiva, Fábio Rodrigues Ferreira

; Panis, Carolina

; Bezerra, Rafael dos Santos

; Ferrasa, Adriano

; Cecchini, Alessandra Lourenço

; Medeiros, Alexandra Ivo de

; Almeida, Ana Marisa Fusco

; Ramão, Anelisa

; Boldt, Angelica Beate Winter

; Moya, Carla Fredrichsen

; Chin, Chung Man

; Paula, Daniel de

; Rech, Daniel

; Gradia, Daniela Fiori

; Malheiros, Danielle

; Venturini, Danielle

; Tavares, Eliandro Reis

; Carraro, Emerson

; Ribeiro, Enilze Maria de Souza Fonseca

; Pereira, Evani Marques

; Tuon, Felipe Francisco

; Follador, Franciele Aní Caovilla

; Fernandes, Glaura Scantamburlo Alves

; Volpato, Hélito

; Cólus, Ilce Mara de Syllos

; Oliveira, Jaqueline Carvalho de

; Rodrigues, Jean Henrique da Silva

; Santos, Jean Leandro dos

; Visentainer, Jeane Eliete Laguila

; Brandi, Juliana Cristina

; Serpeloni, Juliana Mara

; Bonini, Juliana Sartori

; Oliveira, Karen Brajão de

; Fiorentin, Karine

; Lucio, Léia Carolina

; Faccin-Galhardi, Ligia Carla

; Ferreto, Lirane Elize Defante

; Lioni, Lucy Megumi Yamauchi

; Consolaro, Marcia Edilaine Lopes

; Vicari, Marcelo Ricardo

; Arbex, Marcos Abdo

; Pileggi, Marcos

; Watanabe, Maria Angelica Ehara

; Costa, Maria Antônia Ramos

; Giannini, Maria José S. Mendes

; Amarante, Marla Karine

; Khalil, Najeh Maissar

; Lima Neto, Quirino Alves de

; Herai, Roberto H.

; Guembarovski, Roberta Losi

; Shinsato, Rogério N.

; Mainardes, Rubiana Mara

; Giuliatti, Silvana

; Yamada-Ogatta, Sueli Fumie

; Gerber, Viviane Knuppel de Quadros

; Pavanelli, Wander Rogério

; Silva, Weber Claudio da

; Petzl-Erler, Maria Luiza

; Valente, Valeria

; Soares, Christiane Pienna

; Cavalli, Luciane Regina

; Silva Jr, Wilson Araujo

Genetics and Molecular Biology

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2021, Volume 44 N. 1 elocation e20200452

Abstract: En | Text: En | PDF: En

Abstract Coronavirus disease 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus type 2 (SARS-CoV-2), is the largest pandemic in modern history with very high infection rates and considerable mortality. The disease, which emerged in China’s Wuhan province, had its first reported case on December 29, 2019, and spread rapidly worldwide. On March 11, 2020, the World Health Organization (WHO) declared the COVID-19 outbreak a pandemic and global health emergency. Since the outbreak, efforts to develop COVID-19 vaccines, engineer new drugs, and evaluate existing ones for drug repurposing have been intensively undertaken to find ways to control this pandemic. COVID-19 therapeutic strategies aim to impair molecular pathways involved in the virus entrance and replication or interfere in the patients’ overreaction and immunopathology. Moreover, nanotechnology could be an approach to boost the activity of new drugs. Several COVID-19 vaccine candidates have received emergency-use or full authorization in one or more countries, and others are being developed and tested. This review assesses the different strategies currently proposed to control COVID-19 and the issues or limitations imposed on some approaches by the human and viral genetic variability.

https://doi.org/10.1590/1678-4685-gmb-2020-0452

MÉTODO MANUAL PARA DEPOSIÇÃO DE TINTAS FOTOLUMINESCENTES BASEADAS EM LOFS MISTAS APLICADO A CODIFICAÇÃO DE DOCUMENTOS
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Nogueira, Millayd M.

; Costa, Luiz H. M.

; Reis, Jakson N. C.

; Araújo, Antonio Marcos U.

; Moura Neto, Érico de

; Nascimento, Jarley F. S.

Química Nova

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dec 2020, Volume 43 N. 10 Pages 1393 - 1396

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

In this work, the process of synthesis of Metal-Organic Frameworks containing lanthanide ions (LOFs), accelerated via a precipitating agent, capable of accelerating the process of nucleation of MOF crystals, in order to explore the optical properties of this precursor solution (SP_Gd/EU-MOF), as a quick-response photoluminescent material in the coding of official documents. The SP_Gd/Eu-MOF was deposited on the paper substrates manually, using pilot board master liquid ink pens with medium tip. The SP_Gd/Eu-MOF, was characterized by photoluminescence spectroscopy after crystallization on a vial and at surface of the papers, and the spectra showed identical spectral profiles, showing that the interaction with the substrate surface did not promote significant changes in the site symmetry of Eu3+ ions. After being deposited, the material was excited by UV radiation (λ = 254 nm), and emitted the red color characteristic of the Eu3+ ion. The SP_Gd/Eu-MOF, showed good mechanical stability in the abrasiveness test carried out with a rubber remaining deposited on the substrate, demonstrating it is potential to act as proof of authenticity in the encoding of documents, revealing itself as another low cost alternative for the deposition of photoluminescent inks.

https://doi.org/10.21577/0100-4042.20170632 166 downloads

Characteristics and Surgical Outcomes in Very Elderly Patients (≥75 years) with Renal Cell Carcinoma: Data from the Latin American Renal Cancer Group
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Garza-Gangemi, Adrián M.

; Castillejos-Molina, Ricardo A.

; Gueglio, Guillermo

; Tobia-Gonzalez, Ignacio P.

; Jurado, Alberto M.

; Meza-Montoya, Luis

; Scorticati, Carlos H.

; Henriques-da-Costa, Walter

; Yandian, Juan

; Ubillos, Luis

; Glina, Sidney

; Tobias-Machado, Marcos

; Rodríguez-Faba, Oscar

; Ameri, Carlos

; Nolazco, Alejandro

; Martinez, Pablo

; Franco Carvalhal, Gustavo

; Bengio, Ruben G.

; Arribillaga, Leandro Cristian

; Langenhin, Raúl

; Muguruza, Diego

; Campos-Salcedo, José G.

; Bravo-Castro, Edgar I.

; Mingote, Pablo A.

; Ginestar, Nicolás

; Autran-Gomez, Ana M.

; Puente, Roberto

; Decia, Ricardo

; Cardoso-Guimarães, Gustavo

; Palou-Redorta, Joan

; Abreu-Clavijo, Diego

; Cassio-Zequi, Stenio de

; Rodriguez-Covarrubias, Francisco T.

Revista de investigación clínica

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oct 2020, Volume 72 N. 5 Pages 308 - 315

Abstract: En | Text: En | PDF: En

Background: The incidence of renal cell carcinoma (RCC) is increasing globally due to an aging population and widespread use of imaging studies. Objective: The aim of this study was to describe the characteristics and perioperative outcomes of RCC surgery in very elderly patients (VEP), ≥ 75 years of age. Methods: This is a retrospective comparative study of 3656 patients who underwent the treatment for RCC from 1990 to 2015 in 28 centers from eight Latin American countries. We compared baseline characteristics as well as clinical and perioperative outcomes according to age groups (<75 vs. ≥75 years). Surgical complications were classified with the Clavien-Dindo score. We performed logistic regression analysis to identify factors associated with perioperative complications. Results: There were 410 VEP patients (11.2%). On bivariate analysis, VEP had a lower body mass index (p < 0.01) and higher ASA score (ASA >2 in 26.3% vs. 12.4%, p < 0.01). There was no difference in performance status and clinical stage between the study groups. There were no differences in surgical margins, estimated blood loss (EBL), complication, and mortality rates (1.3% vs. 0.4%, p = 0.17). On multivariate regression analysis, age ≥75 years (odds ratio [OR] 2.33, p < 0.01), EBL ≥ 500 cc (OR 3.34, p < 0.01), and > pT2 stage (OR 1.63, p = 0.04) were independently associated with perioperative complications. Conclusions: Surgical resection of RCC was safe and successful in VEP. Age ≥75 years was independently associated with 30-day perioperative complications. However, the vast majority were low-grade complications. Age alone should not guide decision-making in these patients, and treatment must be tailored according to performance status and severity of comorbidities. (REV INVEST CLIN. 2020;72(5):308-15)

https://doi.org/10.24875/ric.20000018 141 downloads

New records of Boana icamiaba (Anura: Hylidae) in the Brazilian Amazon rainforest
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Anjos, Samuel F. dos

; Wronski, Wanne S. S.

; Anjos, Samuel F. dos

; Wronski, Wanne S. S.

; Penhacek, Marcos

; Noronha, Janaina da Costa

; Pinto, Karll C.

; Oda, Fabrício H.

; Rodrigues, Domingos J.

Caldasia

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dec 2019, Volume 41 N. 2 Pages 442 - 444

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

RESUMEN Boana icamiaba es una especie de anura amazónica descrita recientemente para localidades de la mitad inferior del Río Madeira-Río Tapajós y de los interfluvios de los Ríos Tapajós y Xingu, en los municipios de Juruti, Altamira, Santarém y Itaituba, estado de Pará, norte de Brasil. Proporcionamos los primeros registros de Boana icamiaba en los estados de Mato Grosso y Rondônia, centro y norte de Brasil. Estos registros amplían la distribución conocida a aproximadamente 470 km hacia el sur y cerca de 886 km al suroeste de la localidad más cercana anteriormente registrada.

ABSTRACT Boana icamiaba is an Amazonian anuran species reported for sites in the mid-lower Madeira-Rio Tapajós River and lower Tapajós-Rio, and Xingu River interfluves - municipalities of Juruti, Altamira, Santarém, and Itaituba, state of Pará, northern Brazil. We provided the first records of Boana icamiaba for the states of Mato Grosso and Rondônia, central and northern Brazil, which enlarges the knowledge on its distribution in approximately 470 km southmost and circa 886 km southwestmost from the nearest previously recorded locality.

https://doi.org/10.15446/caldasia.v41n2.74225 323 downloads

10.

Effects of Light Quality and Chemical Elicitors on the Growth Parameters and Rosmarinic Acid Content of in vitro Cultures of Hyptis pectinata (L.) Poit.
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Pedroso, Rita C. N.

; Pimenta, Leticia P.

; Tozatti, Marcos G.

; Branquinho, Núbia A. A.

; Hara, Alessandra C. B. A. M.

; Silva, Fernando H. L.

; Costa, Alan C.

; Silva, Fabiano G.

; Miranda, Carlos E. S.

; Silva, Marcio L. A.

; Cunha, Wilson R.

; Pauletti, Patricia M.

; Januario, Ana H.

Journal of the Brazilian Chemical Society

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nov 2019, Volume 30 N. 11 Pages 2430 - 2437

Abstract: En | Text: En | PDF: En

Hyptis pectinata (L.) Poit is a folk medicinal species in Northeast Brazil. In this work, seedlings of H. pectinata were cultured in vitro under diverse light quality spectra and under the influence of two distinct chemical elicitors, salicylic acid and silver nitrate (SN), at concentrations of 30 and 60 μM. Growth parameters, biomass and rosmarinic acid (RA) content were evaluated. RA may be associated with the functional properties of this plant. In the light quality experiments, the highest level of rosmarinic acid was found under red light (161.65 ± 8.64 μg g-1 DW (dry weight)) at 20 days (4.26-fold higher than the control white light). Among the evaluated elicitors, elicitation with 60 μM SN at 3 days and 30 μM SN at 6 days favored the highest rosmarinic acid content (6361.70 ± 216.96 and 4542.98 ± 92.53 μg g-1 DW, respectively), with relatively high biomass yield and a similar number of leaves and height as those of control seedlings. This approach is new for H. pectinata.

https://doi.org/10.21577/0103-5053.20190159 385 downloads

11.

Water disappearance dynamics in growing-finishing pig production
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Chimainski, Michael

; Ceron, Marcos Speroni

; Kuhn, Micheli Faccin

; Muniz, Henrique da Costa Mendes

; Rocha, Leonardo Tombesi da

; Pacheco, Paulo Santana

; Kessler, Alexandre de Mello

; Oliveira, Vladimir de

Revista Brasileira de Zootecnia

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2019, Volume 48 elocation e20180258

Abstract: En | Text: En | PDF: En

ABSTRACT The objective of this study was to measure the water disappearance in the drinker and the pattern of daily water intake and estimate the amount of water wasted in pig production. The study will also generate information about the daily behaviour of water intake of pigs in the growing and finishing phases. Sixty male pigs with an average initial weight of 44.43 kg subjected to immunocastration were used. Animals received feed and water ad libitum. The animal-performance data, temperature and humidity, and feed and water intake behaviour were collected in real time during the entire experimental period, while water volume consumed was measured daily. The average water disappearance (WD) was 7.98 L, which increased during the studied period, and 29.07% of this corresponds to the estimated water wasted. The daily WD behaviour revealed an increasing pattern throughout the day for growing and finishing periods, with the registered peak at 16:00 and 15:00 h and intake of 6.24 and 9.48 L, respectively. The time spent drinking (TSD) and number of drinker visits (NDV) also showed a peak in the afternoon: 13:00 and 17:00 h for growing and finishing phases, respectively. The TSD was 282.73 and 268.36 s, and the NDV values were 16.13 and 13.84 for growing and finishing phases, respectively. The results demonstrated an increasing pattern during the animal housing period in WD that is proportional to dry matter intake and body weight, and the water wasted represents a significant portion of WD. The daily pattern of WD, TSD, and NDV increase during the total and growing periods, presenting peak activity at 13:00 h. During the finishing phase, TSD and NDV present a pattern similar to the growing phase, but the peak occurs in the last hour of the day.

https://doi.org/10.1590/rbz4820180258 1003 downloads

12.

An in silico Study of Benzophenone Derivatives as Potential Non-Competitive Inhibitors of Trypanosoma cruzi and Leishmania Amazonensis Cysteine Proteinases
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Freitas, Poliany G.

; Castilho, Thiago E.

; Almeida, Leticia de

; Maciel-Rezende, Claudia M.

; Costa, Luciano T.

; Viegas Junior, Claudio

; Marques, Marcos J.

; Santos, Marcelo H. dos

; Silveira, Nelson J. F. da

Journal of the Brazilian Chemical Society

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mar 2018, Volume 29 N. 3 Pages 515 - 527

Abstract: En | Text: En | PDF: En

This study investigates the mechanisms of interaction between benzophenone derivatives and cruzain and Llacys1 (the protein expressed by cysteine protease gene isoform 1 of L. amazonensis) by homology modelling, docking and molecular dynamics simulation. The results predict that the same binding site in cruzain and Llacys1 is involved in complexes with benzophenone derivatives that cause non-competitive inhibition of the enzymes. The Gln residue is conserved among the enzymes, and is shown to be a key residue in the allosteric site of these cysteine proteases and in the interaction with benzophenone derivatives. The binding free energies highlight that the main energetic term contributing to the cruzain- and Llacys1-benzophenone compound interactions is the van der Waals term. Experimental results showed that benzophenone derivatives are promising potential inhibitors of cysteine proteases. Moreover, we found that two benzophenone derivatives are the most effective inhibitors of cruzain and L. amazonensis cysteine protease.

https://doi.org/10.21577/0103-5053.20170164 770 downloads

13.

Effect of Endophytic Fungal Associations on the Chemical Profile of in vitroVochysia divergens Seedlings
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Parpinelli, Bruna A. S.

; Siqueira, Katia A.

; Kellner Filho, Luis C.

; Pimenta, Letícia P.

; Costa, Ricardo M. da

; Parreira, Renato L. T.

; Veneziani, Rodrigo C. S.

; Silva, Marcio L. Andrade e

; Cunha, Wilson R.

; Pauletti, Patrícia M.

; Soares, Marcos A.

; Januario, Ana H.

Journal of the Brazilian Chemical Society

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dec 2017, Volume 28 N. 12 Pages 2375 - 2381

Abstract: En | Text: En | PDF: En

Vochysia divergens (Vochysiaceae) is considered an invasive species in the wetlands of the Brazilian Pantanal, which hinders the cultivation of agricultural species. In this study, we evaluated the chemical profile by HPLC-DAD (high-performance liquid chromatography-diode array detector) of leaves extracts from V. divergens seedlings inoculated with endophytic fungi isolated from V. divergens roots. These fungi were collected on dry (D) and wet (W) seasons in the Pantanal. The presence of tannin hexahydroxydiphenoyl (HHDP)-galloyl-glucose and flavone 3',5'-dimethoxy-luteolin were predominant in the seedlings inoculated with endophytic fungi W experiments at 100 and 80%, respectively. Likewise, flavone 3',5-dimethoxy-luteolin-7-O-β-glucoside showed a similar representation in the two evaluated periods, compared with 5-methoxy-luteolin, which was detected only in seedlings inoculated with W endophytic fungi. This approach is new to V. divergens, which has no scientific data on its in vitro elicitation, in the search for a better understanding of the ecological relationships of this species.

https://doi.org/10.21577/0103-5053.20170091 597 downloads

14.

Terpinen-4-ol, tyrosol, and β-lapachone as potential antifungals against dimorphic fungi
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Brilhante, Raimunda Sâmia Nogueira

; Caetano, Érica Pacheco

; Lima, Rita Amanda Chaves de

; Marques, Francisca Jakelyne de Farias

; Castelo-Branco, Débora de Souza Collares Maia

; Melo, Charlline Vládia Silva de

; Guedes, Glaucia Morgana de Melo

; Oliveira, Jonathas Sales de

; Camargo, Zoilo Pires de

; Moreira, José Luciano Bezerra

; Monteiro, André Jalles

; Bandeira, Tereza de Jesus Pinheiro Gomes

; Cordeiro, Rossana de Aguiar

; Rocha, Marcos Fábio Gadelha

; Sidrim, José Júlio Costa

Brazilian Journal of Microbiology

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dec 2016, Volume 47 N. 4 Pages 917 - 924

Abstract: En | Text: En | PDF: En

Abstract This study aimed to evaluate the in vitro antifungal activity of terpinen-4-ol, tyrosol, and β-lapachone against strains of Coccidioides posadasii in filamentous phase (n = 22) and Histoplasma capsulatum in both filamentous (n = 40) and yeast phases (n = 13), using the broth dilution methods as described by the Clinical and Laboratory Standards Institute, to determine the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of these compounds. The mechanisms of action of these compounds were also investigated by analyzing their effect on cell membrane permeability and ergosterol synthesis. The MIC and MFCf these compounds against C. posadasii, mycelial H. capsulatum, and yeast-like H. capsulatum, were in the following ranges: 350-5720 µg/mL, 20-2860 µg/mL, and 40-1420 µg/mL, respectively for terpinen-4-ol; 250-4000 µg/mL, 30-2000 µg/mL, and 10-1000 µg/mL, respectively, for tyrosol; and 0.48-7.8 µg/mL, 0.25-16 µg/mL, and 0.125-4 µg/mL, respectively for β-lapachone. These compounds showed a decrease in MIC when the samples were subjected to osmotic stress, suggesting that the compounds acted on the fungal membrane. All the compounds were able to reduce the ergosterol content of the fungal strains. Finally, tyrosol was able to cause a leakage of intracellular molecules.

https://doi.org/10.1016/j.bjm.2016.07.015 1107 downloads

15.

Antiretroviral drugs saquinavir and ritonavir reduce inhibitory concentration values of itraconazole against Histoplasma capsulatum strains in vitro
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Brilhante, Raimunda Sâmia Nogueira

; Caetano, Érica Pacheco

; Riello, Giovanna Barbosa

; Guedes, Glaucia Morgana de Melo

; Castelo-Branco, Débora de Souza Collares Maia

; Fechine, Maria Auxiliadora Bezerra

; Oliveira, Jonathas Sales de

; Camargo, Zoilo Pires de

; Mesquita, Jacó Ricarte Lima de

; Monteiro, André Jalles

; Cordeiro, Rossana de Aguiar

; Rocha, Marcos Fábio Gadelha

; Sidrim, José Júlio Costa

Brazilian Journal of Infectious Diseases

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apr 2016, Volume 20 N. 2 Pages 155 - 159

Abstract: En | Text: En | PDF: En

Abstract Recent studies have shown that some drugs that are not routinely used to treat fungal infections have antifungal activity, such as protease inhibitor antiretroviral drugs. This study investigated the in vitro susceptibility of Histoplasma capsulatum var. capsulatum to saquinavir and ritonavir, and its combination with the antifungal itraconazole. The susceptibility assay was performed according to Clinical and Laboratory Standards Institute guidelines. All strains were inhibited by the protease inhibitor antiretroviral drugs. Saquinavir showed minimum inhibitory concentrations ranging from 0.125 to 1 μg mL−1 for both phases, and ritonavir presented minimum inhibitory concentrations ranging from 0.0312 to 4 μg mL−1and from 0.0625 to 1 μg mL−1 for filamentous and yeast phase, respectively. Concerning the antifungal itraconazole, the minimum inhibitory concentration values ranged from 0.0019 to 0.125 μg mL−1 and from 0.0039 to 0.0312 μg mL−1 for the filamentous and yeast phase, respectively. The combination of saquinavir or ritonavir with itraconazole was synergistic against H. capsulatum, with a significant reduction in the minimum inhibitory concentrations of both drugs against the strains (p < 0.05). These data show an important in vitro synergy between protease inhibitors and itraconazole against the fungus H. capsulatum.

https://doi.org/10.1016/j.bjid.2015.11.003 937 downloads

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