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Late Clearance of Chronic Hepatitis C: A Rare Case Report
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Soares, Leonor Coutinho

; Matos, André Rebelo

; Vieira, Marta Mello

; Cruz, Rita

; Moreira, Laura

; Azevedo, Luísa

Medicina Interna

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jun 2023, Volume 30 N. 2 Pages 34 - 36

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Hepatitis C virus (HCV) infection is one of the leading causes of chronic liver disease worldwide. The long-term impact of HCV infection is highly variable, from minimal changes to extensive fibrosis and cirrhosis, with or without progression to hepatocellular carcinoma. Spontaneous viral clearance of HCV, defined by sustained undetectable serum viral load concentrations, occurs in about 20%-25% of those infected, usually within the first 6 to 12 months after primary infection. We present the case of a patient admitted to an internal medicine ward with a likely chronic HCV infection, without epidemiological context, but with established liver disease and cirrhosis, who developed a process of spontaneous elimination, due to acute Epstein Barr virus infection.

Resumo A infeção pelo vírus da hepatite C (HCV) é uma das principais causas de doença hepática crónica em todo o mundo. As consequências da infeção a longo prazo são altamente variáveis, desde alterações hepáticas ligeiras até fibrose e cirrose, com possível progressão para carcinoma hepatocelular. A eliminação espontânea do HCV é definida como persistência carga viral indetetável de forma sustentada e acontece em 20%-25% dos infetados, geralmente nos primeiros 6 a 12 meses pós infeção. Os autores apresentam um caso de uma doente internada numa enfermaria de medicina interna com uma provável infeção crónica por HCV, não previamente conhecida e sem contexto epidemiológico, a condicionar doença hepática com cirrose, que desenvolveu um processo de eliminação espontânea no contexto de infeção vírica aguda.

https://doi.org/10.24950/rspmi.1087

Check-All-That-Apply method for sensory characterization of pork from immunocastrated male pigs fed different oil sources
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Silva, Julia Pereira Martins da

; Almeida, Vivian Vezzoni

; Schinckel, Allan Paul

; Meira, Ariana Nascimento

; Moreira, Gabriel Costa Monteiro

; Pian, Laura Woigt

; Campos, Débora de

; Gomes, Julia Dezen

; Gonçales, Janaína Lustosa

; Dargelio, Mariana Damiames Baccarin

; Patinho, Iliani

; Saldaña, Erick

; Contreras-Castillo, Carmen Josefina

; Coutinho, Luiz Lehmann

; Luchiari Filho, Albino

; Nuñez, Amoracyr José Costa

; Cesar, Aline Silva Mello

Scientia Agricola

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2023, Volume 80 elocation e20220019

Abstract: En | Text: En | PDF: En

ABSTRACT In the last decade, other quality attributes have emerged as the main aspects that impact pork consumers acceptance, such as environmentally friendly production, nutritional value, and animal welfare. This study applies a Check-All-That-Apply (CATA) questionnaire for sensory characterization of loins from genetically lean immunocastrated male pigs fed diets containing either a standard commercial diet with 1.5 % soybean oil (control) or 3 % oil from either soybean oil (SO), canola oil (CO), or fish oil (FO) during the growing-finishing phases. Twenty CATA attributes for loin samples were generated. We interviewed 101 consumers to select all the CATA terms that they considered suitable to characterize sensory attributes of longissimus lumborum muscle samples of pigs from each dietary treatment. The CATA results indicated differences among pork loin samples depending on the source and inclusion level of dietary oil. Loins from pigs fed 3 % SO were characterized by a higher frequency of the “juicy texture” attribute (p < 0.05) and a lower frequency of the “dry texture” attribute (p < 0.05) compared to loins from 3 % FO-fed pigs. Moreover, loins from pigs fed 3 % SO had a lower citation frequency of the “tasteless” attribute (p < 0.05) compared to loins from 3 % FO-fed pigs. The attributes “cooked pork meat-like taste”, “juicy texture”, “tender texture”, and “brightness” were placed close to the overall liking. “Tender texture”, “juicy texture”, “pork meat-like” (odor and taste), and “cooked pork meat-like taste” attributes were considered drivers of liking. Feeding genetically lean immunocastrated male pigs with diets containing 3 % SO may be advisable from a pork sensory quality perspective.

https://doi.org/10.1590/1678-992x-2022-0019

Exercise Testing, Family History, and Subclinical Atherosclerosis Markers for Cardiovascular Risk Reclassification in Middle-Aged Women
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Coutinho, Ricardo Quental

; Montarroyos, Ulisses Ramos

; Barros, Isly Maria Lucena de

; Guimarães, Maria José Bezerra

; Leão, Ana Paula Dornelas

; Costa, Laura Olinda Bregieiro Fernandes

; Medeiros, Ana Kelley de Lima

; Monteiro, Maria de Fátima

; Ferreira, Moacir de Novaes Lima

; Chalela, William Azem

; Pedrosa, Rodrigo Pinto

International Journal of Cardiovascular Sciences

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aug 2021, Volume 34 N. 4 Pages 383 - 392

Abstract: En | Text: En | PDF: En

Abstract Background Cardiovascular diseases are the main cause of death in women and the accuracy of currently available risk scores is questionable. Objective To reclassify the risk estimated by the Framingham Risk Score (FRS) in asymptomatic middle-aged women by incorporating family history, exercise testing variables, and subclinical atherosclerosis markers. Methods This cross-sectional study included 509 women (age range, 46-65 years) without cardiovascular symptoms. Those at low or intermediate risk by the FRS were reclassified to a higher level considering premature family history of acute myocardial infarction and/or sudden death; four variables from exercise testing; and two variables related to subclinical atherosclerosis markers. The homogeneity of these variables according to the FRS was verified by Pearson chi-square test (p<0.05). Results According to the FRS, 80.2%, 6.2%, and 13.6% of the women were classified as low (<5%), intermediate (5-10%), and high (>10%) risks, respectively. The intermediate-risk stratum showed the highest increase (from 6.2% to 33.3%) with addition of family history; followed by addition of chronotropic index <80% (to 24.2%); functional capacity <85% (22.2%), coronary calcium score >0 (20.6%); decreased one-minute heart rate recovery ≤12 bpm (15.2%); carotid intima-media thickness >1 mm and/or carotid plaque (13.8%) and ST-segment depression (9.0%). The high-risk stratum increased to 14.4% with the addition of reduced heart rate recovery and to 17.1% with the coronary calcium score. Conclusion Incorporation of premature family history of cardiovascular events, exercise testing abnormal parameters, and subclinical atherosclerosis markers into the FRS led to risk reclassification in 3.0-29.7% of asymptomatic middle-aged women, mainly by an increase from low to intermediate risk.

https://doi.org/10.36660/ijcs.20200414 3 downloads

Diretriz Brasileira de Cardio-oncologia – 2020
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Hajjar, Ludhmila Abrahão

; Costa, Isabela Bispo Santos da Silva da

; Lopes, Marcelo Antônio Cartaxo Queiroga

; Hoff, Paulo Marcelo Gehm

; Diz, Maria Del Pilar Estevez

; Fonseca, Silvia Moulin Ribeiro

; Bittar, Cristina Salvadori

; Rehder, Marília Harumi Higuchi dos Santos

; Rizk, Stephanie Itala

; Almeida, Dirceu Rodrigues

; Fernandes, Gustavo dos Santos

; Beck-da-Silva, Luís

; Campos, Carlos Augusto Homem de Magalhães

; Montera, Marcelo Westerlund

; Alves, Sílvia Marinho Martins

; Fukushima, Júlia Tizue

; Santos, Maria Verônica Câmara dos

; Negrão, Carlos Eduardo

; Silva, Thiago Liguori Feliciano da

; Ferreira, Silvia Moreira Ayub

; Malachias, Marcus Vinicius Bolivar

; Moreira, Maria da Consolação Vieira

; Valente Neto, Manuel Maria Ramos

; Fonseca, Veronica Cristina Quiroga

; Soeiro, Maria Carolina Feres de Almeida

; Alves, Juliana Barbosa Sobral

; Silva, Carolina Maria Pinto Domingues Carvalho

; Sbano, João

; Pavanello, Ricardo

; Pinto, Ibraim Masciarelli F.

; Simão, Antônio Felipe

; Dracoulakis, Marianna Deway Andrade

; Hoff, Ana Oliveira

; Assunção, Bruna Morhy Borges Leal

; Novis, Yana

; Testa, Laura

; Alencar Filho, Aristóteles Comte de

; Cruz, Cecília Beatriz Bittencourt Viana

; Pereira, Juliana

; Garcia, Diego Ribeiro

; Nomura, Cesar Higa

; Rochitte, Carlos Eduardo

; Macedo, Ariane Vieira Scarlatelli

; Marcatti, Patricia Tavares Felipe

; Mathias Junior, Wilson

; Wiermann, Evanius Garcia

; Val, Renata do

; Freitas, Helano

; Coutinho, Anelisa

; Mathias, Clarissa Maria de Cerqueira

; Vieira, Fernando Meton de Alencar Camara

; Sasse, André Deeke

; Rocha, Vanderson

; Ramires, José Antônio Franchini

; Kalil Filho, Roberto

Arquivos Brasileiros de Cardiologia

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nov 2020, Volume 115 N. 5 Pages 1006 - 1043

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20201006 4180 downloads

Free carnitine and branched chain amino acids are not good biomarkers in Huntington’s disease
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CASTILHOS, Raphael Machado

; AUGUSTIN, Marina Coutinho

; SANTOS, José Augusto dos

; PEDROSO, José Luiz

; BARSOTTINI, Orlando

; SABA, Roberta

; FERRAZ, Henrique Ballalai

; VARGAS, Fernando Regla

; FURTADO, Gabriel Vasata

; Polese-BONATTO, Marcia

; RODRIGUES, Luiza Paulsen

; SENA, Lucas Schenatto

; VARGAS, Carmen Regla

; SARAIVA-PEREIRA, Maria Luiza

; JARDIM, Laura Bannach

; NEUROGENÉTICA, Rede

Arquivos de Neuro-Psiquiatria

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feb 2020, Volume 78 N. 2 Pages 81 - 87

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Introdução: A doença de Huntington (DH), causada por uma repetição CAG expandida no HTT, não possui tratamento e biomarcadores são necessários para futuros ensaios clínicos. Objetivo: Nosso objetivo foi verificar se os níveis de carnitina livre e aminoácidos de cadeia ramificada se comportam como potenciais biomarcadores na DH. Métodos: Portadores sintomáticos e assintomáticos e controles foram recrutados. Idade, sexo, índice de massa corporal (IMC), idade de início, duração da doença, escores UHDRS e trato CAG expandido foram obtidos; valina, leucina, isoleucina e carnitina livre foram medidas. Foram realizadas análises basal e longitudinal. Resultados: Setenta e quatro portadores sintomáticos, 20 portadores assintomáticos e 22 não portadores foram incluídos. No início do estudo, os níveis de valina estavam reduzidos em portadores de DH sintomáticos e assintomáticos quando comparados aos não portadores. Não foram observadas diferenças nos níveis de carnitina livre ou isoleucina + leucina entre os grupos. O IMC dos indivíduos sintomáticos foi menor que o dos não portadores. Níveis de valina correlacionaram-se com o IMC. Avaliação de acompanhamento foi realizada em 43 indivíduos sintomáticos. A pontuação do escore motor total da UHDRS aumentou 4,8 pontos/ano em média. Não foram observadas reduções significativas no IMC ou na valina, enquanto os níveis de carnitina livre e isoleucina+leucina aumentaram. Conclusões: Embora os níveis de valina tenham sido menores nos portadores de DH e estivessem relacionados às perdas de IMC observadas em indivíduos pré-sintomáticos, nenhum desses metabólitos parece ser biomarcador para a DH.

ABSTRACT Background: Huntington’s disease (HD), caused by an expanded CAG repeat at HTT, has no treatment, and biomarkers are needed for future clinical trials. Objective: The objective of this study was to verify if free carnitine and branched chain amino acids levels behave as potential biomarkers in HD. Methods: Symptomatic and asymptomatic HD carriers and controls were recruited. Age, sex, body mass index (BMI), age of onset, disease duration, UHDRS scores, and expanded CAG tract were obtained; valine, leucine, isoleucine, and free carnitine were measured. Baseline and longitudinal analysis were performed. Results: Seventy-four symptomatic carriers, 20 asymptomatic carriers, and 22 non-carriers were included. At baseline, valine levels were reduced in symptomatic and asymptomatic HD carriers when compared to non-carriers. No difference in free carnitine or isoleucine+leucine levels were observed between groups. BMI of symptomatic individuals was lower than those of non-carriers. Valine levels correlated with BMI. Follow-up evaluation was performed in 43 symptomatic individuals. UHDRS total motor score increased 4.8 points/year on average. No significant reductions in BMI or valine were observed, whereas free carnitine and isoleucine+leucine levels increased. Conclusions: Although valine levels were lower in HD carriers and were related to BMI losses observed in pre-symptomatic individuals, none of these metabolites seem to be biomarkers for HD.

https://doi.org/10.1590/0004-282x20190152 937 downloads

Fábrica da nutrição neoliberal: elementos para uma discussão sobre as novas abordagens comportamentais
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Seixas, Cristiane Marques

; Casemiro, Juliana Pereira

; Coutinho, Carolina de Oliveira

; Conde, Thais Nascimento

; Brandão, Ana Laura

Physis: Revista de Saúde Coletiva

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2020, Volume 30 N. 4 elocation e300411

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo A aplicação de teorias do comportamento em diversas áreas tem despertado o interesse em investigar como essas teorias são incorporadas pelo campo da Alimentação e Nutrição, problematizando sua interdisciplinaridade. Este artigo busca contextualizar a Nutrição como ciência e seu desenvolvimento num contexto social em que o neoliberalismo opera como sistema de gestão da vida política, econômica e social. Visam-se reunir elementos teóricos relativos à noção de comportamento extraídos do campo da psicologia a fim de contribuir para o aprofundamento das reflexões acerca da emergência de técnicas baseadas em teorias do comportamento, tais como a Nutrição Comportamental, o Mindful Eating e o Comer Intuitivo, além de apresentar ponderações sobre os limites relacionados à aplicação dessas abordagens na formação e na prática dos profissionais de saúde.

Abstract The application of behavioral theories in several areas has aroused the interest in investigating how these theories are incorporated by the field of Food and Nutrition, problematizing its interdisciplinarity. This paper aims to contextualize Nutrition as a science and its development in a social context in which neoliberalism operates as a system for managing political, economic, and social life. The aim is to gather theoretical elements related to the notion of behavior extracted from the field of Psychology in order to contribute to the deepening of reflections on the emergence of techniques based on theories of behavior, such as Behavioral Nutrition, Mindful Eating and Intuitive Eating, in addition to presenting considerations on the limits related to the application of these approaches in the training and practice of health professionals.

https://doi.org/10.1590/s0103-73312020300411 2734 downloads

Fábrica da nutrição neoliberal: elementos para uma discussão sobre as novas abordagens comportamentais
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Seixas, Cristiane Marques

; Casemiro, Juliana Pereira

; Coutinho, Carolina de Oliveira

; Conde, Thais Nascimento

; Brandão, Ana Laura

Physis: Revista de Saúde Coletiva

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2020, Volume 30 N. 4 elocation e300411

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/s0103-73312020300411

Reliability of Two Methods of Evaluation of the Apical Limit of Obturation of Root Canals of Primary Teeth: A Pilot Study
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Duarte, Maysa Lannes

; Pepino, Julia Cocchiarale

; Sancas, Mariana Coutinho

; Moreira, Jéssica Pronestino de Lima

; Neves, Aline de Almeida

; Pintor, Andréa Vaz Braga

; Primo, Laura Guimarães

Pesquisa Brasileira em Odontopediatria e Clínica Integrada

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2020, Volume 20 elocation e5108

Abstract: En | Text: En | PDF: En

Abstract Objective: To verify the concordance in the evaluation of the apical limit of obturation (ALO) in filled root canals of primary teeth between digital and visual methods. Material and Methods: Twenty periapical radiographs of endodontically treated primary teeth were digitalized and evaluated by an endodontics specialist (E1), a PhD pediatric dentist (E2), and a MSc general dentist (E3). Calibrated evaluators (Kappa = 1.00) analysed the images in a light-isolated environment two times (D1 and D2) with a one-week interval between evaluations. ALO scores were categorized as overfilled, flush-filled and underfilled. Results: The intra-rater reliability between methods was 0.82 (D1) and 0.75 (D2) for E1, 0.93 (D1 and D2) for E2, and 0.94 (D1 and D2) for E3. Inter-rater reliability ranged from 0.71 (E1 × E3) and 1.00 (E1 × E2) for the visual method to 0.76 (E1 × E3) and 0.88 (E1 × E2) for the digital method. Spearman correlation coefficients showed a similar ranking among the evaluators. There was greater disagreement among the underfilled and ideal scores. For all evaluators, the digital method favoured the identification of the ideal score. Conclusion: Both methods are suitable for the determination of the ALO of filled primary teeth and can be used in clinical practice.

https://doi.org/10.1590/pboci.2020.058 325 downloads

Overview of meta-analysis on prevention and treatment of childhood obesity
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Bahia, Luciana

; Schaan, Camila Wohlgemuth

; Sparrenberger, Karen

; Abreu, Gabriela de Azevedo

; Barufaldi, Laura Augusta

; Coutinho, Walmir

; Schaan, Beatriz D.

Jornal de Pediatria

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aug 2019, Volume 95 N. 4 Pages 385 - 400

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Objetivos: Este estudo teve como objetivo avaliar a qualidade das revisões sistemáticas sobre prevenção e tratamento não farmacológico do sobrepeso e da obesidade em crianças e adolescentes. Fontes de dados: Foi realizada uma busca em bases de dados eletrônicas (Medline via Pubmed, Web of Science, Scopus, LILACS, The Cochrane Library e Ensaios Clínicos), incluindo apenas revisões sistemáticas com meta-análise. As revisões foram selecionadas por dois pesquisadores e um terceiro resolveu as divergências. A lista de recomendações do PRISMA foi seguida. Síntese dos dados: Foram identificados 4.574 publicações, e 24 foram incluídas após seleção. Seis publicações eram sobre prevenção da obesidade, 17 sobre tratamento da obesidade e 1 sobre intervenções mistas para prevenção e tratamento da obesidade. As intervenções eram muito heterogêneas e mostraram pouco ou nenhum efeito sobre o peso ou índice de massa corporal. Intervenções mistas que incluíam dieta, exercícios, ações para reduzir o comportamento sedentário e programas que envolviam a escola ou as famílias mostraram alguns efeitos positivos de curto prazo. Revisões que analisaram fatores de risco cardiovascular demonstraram melhoras significativas em curto prazo. Conclusão: As revisões sistemáticas de intervenções para prevenir ou reduzir a obesidade em crianças e adolescentes geralmente mostraram pouco ou nenhum efeito sobre o peso ou índice de massa corporal, embora o perfil cardiovascular possa ter melhorado. Intervenções mistas demonstraram melhores efeitos, mas o impacto em longo prazo dos tratamentos da obesidade de crianças e adolescentes ainda não está claro.

Abstract Objectives: This study aimed to assess the quality of systematic reviews on prevention and non-pharmacological treatment of overweight and obesity in children and adolescents. Data source: A search was done in electronic databases (Medline via PubMed, Web of Science, Scopus, LILACS, the Cochrane Library, and Clinical Trials), including only systematic reviews with meta-analysis. Reviews were selected by two researchers, and a third one solved the divergences. PRISMA statement and checklist were followed. Summary of data: A total of 4574 records were retrieved, including 24 after selection. Six reviews were on obesity prevention, 17 on obesity treatment, and one on mixed interventions for prevention and treatment of obesity. The interventions were very heterogeneous and showed little or no effects on weight or body mass index. Mixed interventions that included dieting, exercise, actions to reduce sedentary behavior, and programs involving the school or families showed some short-term positive effects. Reviews that analyzed cardiovascular risk factors demonstrated significant improvements in the short-term. Conclusion: The systematic reviews of interventions to prevent or reduce obesity in children and adolescents generally showed little or no effects on weight or body mass index, although cardiovascular profile can be improved. Mixed interventions demonstrated better effects, but the long-term impact of obesity treatments of children and adolescents remains unclear.

https://doi.org/10.1016/j.jped.2018.07.009 4561 downloads

10.

Minimal prevalence of Huntington’s disease in the South of Brazil and instability of the expanded CAG tract during intergenerational transmissions
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Castilhos, Raphael Machado de

; Santos, José Augusto dos

; Augustin, Marina Coutinho

; Pedroso, José Luiz

; Barsottini, Orlando

; Saba, Roberta

; Ferraz, Henrique Ballalai

; Godeiro Junior, Clécio

; Vargas, Fernando Regla

; Salarini, Diego Zanotti

; Furtado, Gabriel Vasata

; Polese-Bonatto, Marcia

; Rodrigues, Luiza Paulsen

; Sena, Lucas Schenatto

; Saraiva-Pereira, Maria Luiza

; Jardim, Laura Bannach

Genetics and Molecular Biology

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jun 2019, Volume 42 N. 2 Pages 329 - 336

Abstract: En | Text: En | PDF: En

Abstract Huntington’s disease (HD) is due to dominant expansions of the CAG repeat of the HTT gene. Meiotic instability of the (CAG)n might impact the disorder frequency. We report on HD minimal prevalence in Rio Grande do Sul (RS) state, Brazil, and on intergenerational instability of the (CAG)n in HD families. Symptomatic and at-risk subjects from 179 HD families were ascertained between 2013 and 2016. Clinical, molecular and family history data were obtained. Expanded (CAG)n length differences between parent and child (delta-expanded-(CAG)n) were calculated. Effect of parental age on the (CAG)n instability upon transmission was inferred by correlating delta-expanded-(CAG)n between siblings to their age differences. HD minimal prevalence in RS state was estimated as 1.85:100,000 inhabitants. Alleles with (CAG)27-35 were found on 21/384 non-disease associated chromosomes (5.5%); among 253 expanded alleles, four (1.6%) were within reduced penetrance range with (CAG)36-39. In 32 direct transmissions, mean instability was larger among paternal than maternal transmissions. In direct transmissions and in 51 sibling pairs, parental age at the time of child birth were not correlated with delta-expanded-(CAG)n. Briefly, HD prevalence in RS state was lower than those reported for European populations. Expanded (CAG)n transmissions were unstable and not associated to parental age.

https://doi.org/10.1590/1678-4685-gmb-2018-0032 1288 downloads

11.

Non Electrocardiographic alterations in exercise testing in asymptomatic women. Associations with cardiovascular risk factors
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Coutinho, Ricardo Quental

; Montarroyos, Ulisses Ramos

; de Barros, Isly Maria Lucena

; Guimarães, Maria José Bezerra

; Costa, Laura Olinda Bregieiro Fernandes

; de Lima Medeiros, Ana Kelley

; de Fátima Monteiro, Maria

; de Novaes Lima Ferreira, Moacir

; Chalela, William Azem

; Pedrosa, Rodrigo

Clinics

Journal Metrics
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2019, Volume 74 elocation e1005

Abstract: En | Text: En | PDF: En

OBJECTIVES: To estimate the prevalence of exercise testing alterations in middle-aged women without symptoms of heart disease and to verify the associations of functional capacity and heart rate behavior during and after exercise with cardiovascular risk factors. METHODS: A cross-sectional study was conducted with 509 asymptomatic women aged between 46 and 65 years who underwent clinical evaluations and exercise testing (Bruce protocol). The heart rate behavior was evaluated by the maximal predicted heart rate achieved, chronotropic index and recovery heart rate. RESULTS: The mean age was 56.4±4.8 years, and 13.4% of the patients had a Framingham risk score above 10%. In the exercise treadmill testing, 58.0% presented one or more of the following alterations (listed in order of ascending prevalence): symptoms (angina, dyspnea, and dizziness), ST-segment depression, arrhythmia, reduction in recovery heart rate of ≤12 bpm at 1 minute, altered maximal predicted heart rate achieved, abnormal blood pressure, functional capacity deficiency, and altered chronotropic index. In the multivariate analysis, the following associations (odds ratio) were observed for these alterations: chronotropic index was associated with obesity (2.08) and smoking (4.47); maximal predicted heart rate achieved was associated with smoking (6.45); reduction in the recovery heart rate at 1 minute was associated with age (1.09) and obesity (2.78); functional capacity was associated with age (0.92), an overweight status (2.29) and obesity (6.51). CONCLUSIONS: More than half of middle-aged women without cardiovascular symptoms present alterations in one or more exercise testing parameters. Alterations in the functional capacity or heart rate behavior, as verified by exercise testing, are associated with age, smoking, an overweight status and obesity.

https://doi.org/10.6061/clinics/2019/e1005 366 downloads

12.

Agronomical indicators and incidence of insect borers of tomato fruits protected with non-woven fabric bags
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Filgueiras, Rosenya Michely Cintra

; Pastori, Patrik Luiz

; Pereira, Fabrício Fagundes

; Coutinho, Cristiane Ramos

; Kassab, Samir Oliveira

; Bezerra, Laura Carla Marinho

Ciência Rural

Journal Metrics
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2017, Volume 47 N. 6 elocation e20160278

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: O ensacamento de frutos é uma eficiente técnica de controle mecânico utilizado na fruticultura. No entanto, existem poucos estudos sobre sua eficiência em hortaliças como, por exemplo, o tomate. O objetivo deste trabalho foi avaliar a eficiência do ensacamento das flores e/ou frutos de tomate com sacos TNT para o controle de Helicoverpa spp., Neoleucinodes elegantalis e Tuta absoluta, avaliar o efeito dessa técnica sobre a produtividade obtida ao final do ciclo e determinar a melhor época para realização do ensacamento. O ensaio foi realizado em plantio comercial de tomateiro ‘Valerin’ estaqueado, localizado no município de Ubajara, CE. O delineamento experimental foi de blocos casualizados em esquema fatorial 2x4 (plantas pulverizadas versus não pulverizadas sendo que ambas receberam ensacamento com TNT em diferentes estágios fenológicos [ensacamento da flor, ensacamento do cacho com frutos de 1,5cm, ensacamento do cacho com frutos de 3,0cm, cachos não ensacados (Testemunha)], com cinco repetições. Avaliou-se: número de frutos/cacho, número de cachos/planta, peso/fruto, diâmetro longitudinal e transversal, porcentagem de frutos brocados, produtividade, perda provocada pelo ataque de pragas e ganho real obtido. O ensacamento dos cachos de tomate ‘Valerin’ com TNT foi eficaz para o controle de N. elegantalis e, quando o ensacamento foi realizado em cachos com frutos de 1,5cm de diâmetro, proporcionou incremento de 21,5% de produtividade em relação àqueles não ensacados sendo, portanto, o período mais indicado para o ensacamento.

ABSTRACT: Fruit bagging is an efficient mechanical control technique used in fruit growing. However, to date, few studies have evaluated the efficacy of bagging in the cultivation of vegetables, including tomato crops. The objective of this study was to evaluate the effectiveness of bagging of tomato flowers and/or fruits using a non-woven fabric (NWF) for the control of Helicoverpa spp., Neoleucinodes elegantalis, and Tuta absoluta, to evaluate the effect of this technique on the final yield, and determine the optimal period for bagging. Tests were conducted in a commercial crop of staked ‘Valerin’ tomato plants located in the municipality of Ubajara, Ceará State, Brazil. The experimental design was randomized blocks with a 2x4 factorial design (sprayed versus unsprayed plants, and both plant groups were bagged with NWF bags at different growth stages [flowers bagging, bagging of bunches of fruits with a diameter of 1.5cm, bagging of bunches of fruits with a diameter of 3.0cm, and unbagged bunches (control)], with five repetitions. We evaluated the number of fruits per bunch, number of bunches per plant, weight of each fruit, longitudinal and transverse diameter, percentage of bored fruits, yield loss caused by insect infestation, and final yield. Bagging of ‘Valerin’ tomato bunches with NWF bags was effective for the control of N. elegantalis, and productivity increased by 21.5% when bagging was done in bunches of fruits with a diameter of 1.5cm compared with unbagged fruits; therefore, this growth period was the most suitable for bagging.

https://doi.org/10.1590/0103-8478cr20160278 1864 downloads

13.

EFFECTS OF AEROBIC TRAINING ON THE CARDIOMYOCYTES OF THE RIGHT ATRIUM OF MICE
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Oliveira, Vanessa Gonçalves Coutinho de

; Maifrino, Laura Beatriz Mesiano

; Pithon-Curi, Tania Cristina

; França, Elias de

; Souza, Romeu Rodrigues de

Revista Brasileira de Medicina do Esporte

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oct 2016, Volume 22 N. 5 Pages 345 - 349

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Introdução: Os hormônios polipeptídicos (peptídeos natriuréticos, PN) são secretados pelos átrios cardíacos e desempenham um papel importante na regulação da pressão arterial. Objetivo: Avaliar os efeitos do treinamento aeróbico sobre o aparelho secretor de PN nos cardiomiócitos do átrio direito. Métodos: Camundongos com nove meses de idade foram divididos em dois grupos (n = 10): grupo controle (GC) e grupo treinado (GT). O protocolo de treinamento foi realizado em esteira motorizada durante 8 semanas. A pressão sistólica dos animais foi medida no início do experimento (9 meses de idade) e no momento do sacrifício (11 meses). Foram usadas eletromicrografias para quantificar as seguintes variáveis densidade quantitativa e área dos grânulos de PN; volumes relativos (%) de mitocôndrias, retículo endoplasmático e aparelho de Golgi e o volume relativo de eucromatina no núcleo e o número de poros por 10 µm de membrana nuclear. Os resultados foram comparados pelo teste t de Student (p < 0,05). Resultados: Os cardiomiócitos obtidos dos camundongos GT apresentaram maior densidade e área seccional de grânulos secretórios de PN, aumento do volume relativo do retículo endoplasmático, das mitocôndrias e do complexo de Golgi, em comparação com os camundongos GC. Além disso, a densidade quantitativa dos poros nucleares e o volume relativo da eucromatina nuclear foram significantemente superiores em comparação com os camundongos GC. Conclusão: O treinamento aeróbico causou hipertrofia do aparelho secretor dos cardiomiócitos do átrio direito, o que poderia explicar a síntese intensa de peptídeos natriuréticos em camundongos treinados, quando comparados aos não treinados.

ABSTRACT Introduction: Polypeptide hormones (natriuretic peptides, NPs) are secreted by the cardiac atria and play an important role in the regulation of blood pressure. Objective: To evaluate the effects of aerobic training on the secretory apparatus of NPs in cardiomyocytes of the right atrium. Methods: Nine-month-old mice were divided in two groups (n=10): control group (CG) and trained group (TG). The training protocol was performed on a motor treadmill for 8 weeks. Systolic blood pressure was measured at the beginning of the experiment (9 months of age) and at moment of the sacrifice (11 months of age). Electron micrographs were used to quantify the following variables: the quantitative density and area of NP granules, the relative volumes of the mitochondria, endoplasmic reticulum, and Golgi complex and the relative volume of euchromatin in the nucleus and the number of pores per 10 µm of the nuclear membrane. The results were compared by Student's t test (p< 0.05). Results: The cardiomyocytes obtained from TG mice showed increased density and sectional area of secretory granules of NP, higher relative volume of endoplasmic reticulum, mitochondria, and Golgi complex compared with the CG mice. Furthermore, the quantitative density of nuclear pores and the relative volume of euchromatin in the nucleus were significantly higher compared with the CG mice. Conclusion: Aerobic training caused hypertrophy of the secretory apparatus in the cardiomyocytes of right atrium, which could explain the intense synthesis of natriuretic peptides in trained mice with respect to the untrained mice.

RESUMEN Introducción: Las hormonas polipeptídicas (péptidos natriuréticos, PN) son secretadas por las aurículas cardíacas y juegan un papel importante en la regulación de la presión arterial. Objetivo: Evaluar los efectos del entrenamiento aeróbico sobre el aparato secretor de PN en cardiomiocitos de la aurícula derecha. Métodos: Ratones de nueve meses de edad fueron divididos en dos grupos (n = 10): grupo control (GC) y grupo entrenado (GE). El protocolo de entrenamiento se realizó en cinta caminadora durante 8 semanas. La presión arterial sistólica se midió al inicio del experimento (9 meses de edad) y en el momento del sacrificio (11 meses de edad). Las electromicrografías se utilizaron para cuantificar las siguientes variables: la densidad cuantitativa y el área de gránulos de PN; los volúmenes relativos (%) de mitocondrias, del retículo endoplásmico y del aparato de Golgi y el volumen relativo de eucromatina en el núcleo y el número de poros por 10 µm de la membrana nuclear. Los resultados se compararon mediante la prueba t de Student (p < 0,05). Resultados: Los cardiomiocitos obtenidos de los ratones GE mostraron aumento de la densidad y del área seccional de gránulos secretorios de PN, aumento del volumen relativo de retículo endoplásmico, mitocondrias y aparato de Golgi en comparación con los ratones GC. Además, la densidad cuantitativa de los poros nucleares y el volumen relativo de la eucromatina nuclear fueron significativamente mayores en comparación con los ratones CG. Conclusión: El entrenamiento aeróbico causó hipertrofia del aparato secretor en los cardiomiocitos de la aurícula derecha, lo que podría explicar la intensa síntesis de péptidos natriuréticos en ratones entrenados con respecto a los ratones no entrenados.

https://doi.org/10.1590/1517-869220162205155776 2688 downloads

14.

Efeito agudo da utilização do cicloergômetro durante atendimento fisioterapêutico em pacientes críticos ventilados mecanicamente
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Coutinho, William Maia

; Santos, Laura Jurema dos

; Fernandes, João

; Vieira, Silvia Regina Rios

; Forgiarini Junior, Luiz Alberto

; Dias, Alexandre Simões

Fisioterapia e Pesquisa

Journal Metrics
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sep 2016, Volume 23 N. 3 Pages 278 - 283

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Pacientes internados em unidades de terapia intensiva (UTI) e ventilados mecanicamente comumente apresentam disfunção muscular devido à inatividade física, à presença de processos inflamatórios e ao uso de agentes farmacológicos. O objetivo deste estudo foi comparar a utilização aguda do cicloergômetro em pacientes críticos ventilados mecanicamente internados em UTI. Trata-se de um ensaio clínico randomizado, no qual foram incluídos 25 pacientes em ventilação mecânica na UTI do Hospital de Clínicas de Porto Alegre. Foram coletadas, pré e pós-intervenção, variáveis hemodinâmicas e respiratórias, bem como foram avaliadas a troca gasosa, por meio da gasometria arterial, os níveis de lactato e proteína C reativa. O protocolo consistiu de diagonais do método de Facilitação Neuromuscular Proprioceptiva de membros superiores e inferiores e técnicas de higiene brônquica, quando necessário. Já no grupo intervenção foi realizado, além da fisioterapia descrita previamente, o cicloergômetro passivo. A análise foi realizada mediante o programa SPSS 18.0. Os dados contínuos foram expressos em média e desvio-padrão, e o nível de significância adotado foi de 5%. Observou-se alteração estatisticamente significativa em relação à pressão de pico (pré: 25,1±5,9; pós: 21,0±2,7cmH2O; p=0,03) no grupo convencional e ao bicarbonato (pré: 23,5±4,3; pós: 20,6±3,0; p=0,002) no grupo intervenção. Concluiu-se que a utilização do cicloergômetro num protocolo de mobilização precoce não altera a mecânica respiratória, nem a hemodinâmica e não resulta em respostas fisiológicas agudas.

ABSTRACT Mechanically ventilated patients admitted to intensive care units (ICU) usually have muscle dysfunction due to physical inactivity, inflammatory processes, and to the use of pharmacological agents. The objective of this study was to compare the intense use of cycle ergometer in critical mechanically ventilated patients admitted to the intensive care unit (ICU). This is a randomized clinical trial with 25 mechanically ventilated ICU patients from Porto Alegre Teaching Hospital. We collected, pre- and post-intervention, hemodynamic and respiratory variables, and we also assessed the C-reactive protein, through the arterial blood gas test, and lactate levels and gas exchange. The protocol included upper and lower extremity diagonals from the Proprioceptive Neuromuscular Facilitation method and bronchial hygiene exercises when necessary. In the intervention group, in addition of the abovementioned physiotherapy, the group underwent passive cycle ergometer exercises. The analysis was carried out using SPSS 18.0. We used mean and standard deviation to describe continuous data and adopted significance level of 5%. Statistically significant change was observed for peak pressure (pre=25.1±5.9 and post=21.0±2.7 cmH2O; p=0.03) in the conventional group and for bicarbonate (pre: 23.5±4.3 and post: 20.6±3.0; p=0.002) in the intervention group. We concluded thus that neither does cycle ergometer in a protocol for early mobilization alter hemodynamic and respiratory mechanics, nor does it result in acute physiological responses.

RESUMEN Los pacientes hospitalizados en unidades de cuidados intensivos (UCI) y ventilados mecánicamente en general presentan disfunción muscular debido a la falta de practicar actividad física, a la presencia de procesos inflamatorios y a la utilización de fármacos. En este estudio se comparó el uso agudo del cicloergómetro en pacientes críticos ventilados mecánicamente hospitalizados en UCI. Se trata de un estudio clínico aleatorio, en el cual se incluyeron 25 pacientes en ventilación mecánica en la UCI del Hospital de Clínicas de Porto Alegre, Brasil. Se recolectaron, pré y posintervención, las variables hemodinámicas y respiratorias, así como se evaluaron el cambio de gases, mediante la gasometría arterial, los niveles de lactato y la proteína C reactiva. El protocolo estaba formado de diagonales del método de Facilitación Neuromuscular Propioceptiva de los miembros superiores e inferiores y técnicas de higienización de los bronquios, cuando necesarios. En el grupo intervención se realizó, además de la fisioterapia descriptiva preestablecida, el cicloergómetro pasivo. Se realizó el análisis a través del programa SPSS 18.0. Los datos fueron expresados en promedio y desviación-estándar, y el nivel de significación fue de 5%. Se observó alteraciones significativas estadísticamente en relación a la presión máxima (pré: 25,1±5,9; pos: 21,0±2,7cmH2O; p=0,03) en el grupo convencional y al bicarbonato (pré: 23,5±4,3; pos: 20,6±3,0; p=0,002) en el grupo intervención. Se concluyó que el empleo del cicloergómetro en el protocolo de movilización precoz no altera la mecánica respiratoria, la hemodinámica y tampoco resulta en respuestas fisiológicas agudas.

https://doi.org/10.1590/1809-2950/15549123032016 13337 downloads

15.

ERICA: patterns of alcohol consumption in Brazilian adolescents
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Coutinho, Evandro Silva Freire

; França-Santos, Debora

; Magliano, Erika da Silva

; Bloch, Katia Vergetti

; Barufaldi, Laura Augusta

; Cunha, Cristiane de Freitas

; Vasconcellos, Maurício Teixeira Leite de

; Szklo, Moyses

Revista de Saúde Pública

Journal Metrics
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2016, Volume 50 Suppl. 1 elocation 8s

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO OBJETIVO Descrever padrões de consumo de bebidas alcoólicas em adolescentes brasileiros. MÉTODOS Foram investigados adolescentes participantes do Estudo de Riscos Cardiovasculares em Adolescentes (ERICA). Trata-se de estudo transversal, multicêntrico, nacional e de base escolar, que avaliou adolescentes de 1.247 escolas em 124 municípios brasileiros. Os participantes responderam questionário autoaplicável que incluía seção sobre consumo de bebidas alcoólicas. Foram calculadas medidas de frequência relativa (prevalências) e respectivos intervalos de confiança de 95% para as seguintes variáveis: uso de bebidas alcoólicas nos últimos 30 dias, frequência de uso, número de copos ou doses consumidas no período, idade com que bebeu pela primeira vez e tipo de bebida mais consumido. Os dados foram estimados para o País e por macrorregião, sexo e grupo etário. Utilizou-se o módulo survey do programa Stata para análise de dados de amostra complexa. RESULTADOS Foram avaliados 74.589 adolescentes, que representaram 72,9% dos alunos elegíveis. Cerca de 1/5 dos adolescentes consumiram bebidas alcoólicas pelo menos uma vez nos últimos 30 dias e, desses, aproximadamente 2/3 o fizeram em uma ou duas ocasiões no período. Entre os adolescentes que consumiam bebidas alcoólicas, 24,1% beberam pela primeira vez antes de 12 anos de idade, e os tipos de bebidas alcoólicas mais consumidas pelos adolescentes foram os drinques à base de vodca, rum ou tequila e a cerveja. CONCLUSÕES Observou-se prevalência elevada de uso de álcool por adolescentes, assim como um início precoce. Identificou-se ainda uma possível mudança do tipo de bebida de preferência em comparação com investigações anteriores.

ABSTRACT OBJECTIVE To describe the patterns of alcohol consumption in Brazilian adolescents. METHODS We investigated adolescents who participated in the Study of Cardiovascular Risks in Adolescents (ERICA). This is a cross-sectional, national and school-based study, which surveyed adolescents of 1,247 schools from 124 Brazilian municipalities. Participants answered a self-administered questionnaire with a section on alcoholic beverages consumption. Measures of relative frequency (prevalence), and their 95% confidence intervals, were estimated for the following variables: use of alcohol beverages in the last 30 days, frequency of use, number of glasses or doses consumed in the period, age of the first use of alcohol, and most consumed type of drink. Data were estimated for country and macro-region, sex, and age group. The module survey of the Stata program was used for data analysis of complex sample. RESULTS We evaluated 74,589 adolescents, who accounted for 72.9% of eligible students. About 1/5 of adolescents consumed alcohol at least once in the last 30 days and about 2/3 in one or two occasions during this period. Among the adolescents who consumed alcoholic beverages, 24.1% drank it for the first time before being 12 years old, and the most common type of alcoholic beverages consumed by them were drinks based on vodka, rum or tequila, and beer. CONCLUSIONS There is a high prevalence of alcohol consumption among adolescents, as well as their early onset of alcohol use. We also identified a possible change in the preferred type of alcoholic beverages compared with previous research.

https://doi.org/10.1590/s01518-8787.2016050006684 891 downloads

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