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Resumen Introducción: el progreso en los tratamientos para el lupus eritematoso sistémico (LES) resultó en una disminución de la mortalidad; sin embargo, la enfermedad cardiovascular y las complicaciones infecciosas aún son las principales causas de muerte. La evidencia apoya la participación del sistema inmunológico en la generación de la placa aterosclerótica, así como su conexión con las enfermedades autoinmunes. Objetivos: describir la frecuencia de eventos cardiovasculares (ECV) en el Registro de Lupus Eritematoso Sistémico de la Sociedad Argentina de Reumatología (RELESSAR) transversal, así como sus principales factores de riesgo asociados. Materiales y métodos: estudio descriptivo y transversal para el cual se tomaron los pacientes ingresados en el registro RELESSAR transversal. Se describieron las variables sociodemográficas y clínicas, las comorbilidades, score de actividad y daño. ECV se definió como la presencia de al menos una de las siguientes patologías: enfermedad arterial periférica, cardiopatía isquémica o accidente cerebrovascular. El evento clasificado para el análisis fue aquel posterior al diagnóstico del LES. Se conformaron dos grupos macheados por edad y sexo 1:2. Resultados: 1515 pacientes mayores de 18 años participaron del registro. Se describieron 80 pacientes con ECV (5,3%). En este análisis se incluyeron 240 pacientes conformando dos grupos. La edad media fue de 47,8 (14,4) y 47,6 (14,2) en el grupo con y sin ECV respectivamente. Los pacientes con ECV tuvieron mayor duración del LES en meses, mayor índice de Charlson, mayor SLICC (Systemic Lupus International Collaborating Clinics/American College of Rheumatology), mayor frecuencia de manifestaciones neurológicas, síndrome antifosfolípido, hospitalizaciones y uso de ciclofosfamida. Las únicas variables asociadas en el análisis multivariado fueron el índice de Charlson (p=0,004) y el SLICC (p<0,001). Conclusiones: los ECV influyen significativamente en nuestros pacientes, y se asocian a mayor posibilidad de daño irreversible y comorbilidades.

Abstract Introduction: progress in treatments for systemic lupus erythematosus (SLE) has resulted in a decrease in mortality; however, cardiovascular and infectious diseases remain the leading causes of death. Evidence supports the involvement of the immune system in the generation of atherosclerotic plaque, as well as its connection to autoimmune diseases. Objectives: to describe the frequency of cardiovascular disease (CVD) in the cross-sectional RELESSAR registry, as well as its associated variables. Materials and methods: a descriptive and cross-sectional study was performed using patients admitted to the cross-sectional RELESSAR registry. Sociodemographic variables, clinical variables, comorbidities, activity and damage scores were described. CVD was defined as at least one of the following: peripheral arterial disease, ischemic heart disease, or cerebrovascular accident. All patients with at least one CVD were included in our analysis (heart attack, central nervous system vascular disease, and peripheral arteries atherosclerotic disease). The event classified for the analysis was that after the diagnosis of SLE. SLE diagnosis was previous to CVD. Two groups matched by age and sex, 1:2 were formed. Results: a total of 1515 patients older than 18 years participated in the registry. Eighty patients with CVD (5.3%) were described in the registry. Two-hundred and forty patients were included, according to two groups. The mean age was 47.8 (SD 14.4) and 47.6 (SD 14.2) in patients with and without CVD, respectively. Patients with CVD had a longer duration of SLE in months, a higher Charlson index, a higher SLICC, increased frequency of neurological manifestations, antiphospholipid syndrome, hospitalizations, and use of cyclophosphamide. The associated variables in the multivariate were the Charlson Index (p=0.004) and the SLICC (p<0.001). Conclusions: CVDs have a significant influence on our patients, being associated with a greater possibility of damage and comorbidities.

https://doi.org/10.47196/rar.v34i2.747

Estudo do esgoto de um município do sul de Minas Gerais: correlação de variáveis físicas e químicas, casos de COVID-19 e concentração do RNA de SARS-CoV-2
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Abreu, Mariana Aparecida de Freitas

; Siqueira, Juliano Curi de

; Souza, Aline dos Reis

; Ázara, Marina Santos

; Lopes, Bruna Coelho

; Mota Filho, César Rossas

; Batista, Ana Maria Moreira

; Assemany, Paula Peixoto

; Franco, Camila Silva

; Matos, Mateus Pimentel de

; Silva Filho, Marcelo Vieira da

; Siniscalchi, Luciene Alves Batista

Engenharia Sanitaria e Ambiental

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oct 2022, Volume 27 N. 5 Pages 967 - 974

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO A epidemiologia baseada em esgotos é uma importante ferramenta de saúde pública com grande aplicabilidade no enfrentamento à pandemia de COVID-19, visto que indivíduos infectados são capazes de excretar partículas de SARS-CoV-2. Diante desse contexto, este estudo objetivou correlacionar o número de casos de COVID-19 com variáveis físicas e químicas e presença do vírus em amostras de esgoto bruto provenientes de uma estação de tratamento de esgoto (ETE) do município de Lavras (MG) coletadas entre as 19ª e 25ª semanas epidemiológicas. As amostras foram concentradas pelo método de adsorção em membrana eletronegativa, e o RNA de SARS-CoV-2 foi extraído, detectado e quantificado por reação da transcriptase reversa seguida pela reação em cadeia da polimerase (RT-qPCR) utilizando-se oligonucleotídeos e sondas para o gene N. Ademais, as variáveis pH, sólidos suspensos totais e demanda química de oxigênio foram avaliadas. Os casos de COVID-19 foram obtidos de boletins epidemiológicos disponibilizados pela prefeitura. Na 24ª semana epidemiológica, observou-se redução na concentração viral (cópias L-1) concomitantemente às medidas de enfrentamento à pandemia iniciadas pelo município. Correlação positiva forte e significativa (p < 0,05) entre carga viral e número de casos confirmados foi obtida por meio do teste de Spearman, entretanto não houve correlação entre a presença do vírus e as características físicas e químicas do esgoto. Sugere-se, portanto, que novas pesquisas sejam realizadas com a finalidade de rastrear a concentração de SARS-CoV-2 em águas residuárias, corroborando, desse modo, com o enfrentamento à pandemia e a obtenção de sistemas de vigilância epidemiológica por meio do monitoramento de esgotos.

ABSTRACT Wastewater-based epidemiology is an important public health tool with great applicability when facing the COVID-19 pandemic, since infected individuals are able to excrete SARS-CoV-2 particles. In this context, this study aimed to correlate the number of cases of COVID-19 with physical and chemical variables and the presence of the virus in raw sewage samples from a sewage treatment plant (STP) in the municipality of Lavras, Minas Gerais, Brazil, collected between the 19th and 25th epidemiological weeks. The samples were concentrated by electronegative membrane adsorption method and SARS-CoV-2 RNA was extracted, detected, and quantified by RT-qPCR using oligonucleotides and probes for the N gene. Moreover, the variables pH, total suspended solids, and chemical oxygen demand were evaluated. COVID-19 cases were obtained from epidemiological bulletins made available by the municipal government. From the 24th epidemiological week on, a reduction in viral concentration (copies L-1) was observed concomitantly with the pandemic response countermeasures initiated by the municipality. A strong and significant positive correlation (p<0.05) between viral load and number of confirmed cases was obtained through Spearman’s test. However, there was no correlation between the presence of the virus and the physical and chemical characteristics of the sewage. Therefore, it is suggested that further research be carried out in order to track SARS-CoV-2 concentrations in wastewater, thus corroborating with the fight against the pandemic and the achievement of epidemiological surveillance systems based on sewage monitoring.

https://doi.org/10.1590/s1413-415220220006

Lupus en Argentina. .
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Quintana, Rosana

; García, Lucila

; Gobbi, Carla

; Alba, Paula

; Roverano, Susana

; Álvarez, Analia Patricia

; Graf, César Enrique

; Pisoni, Cecilia

; Spindler, Alberto

; Gómez, Catalina

; Figueredo, Heber Matías

; Papasidero, Silvia

; Paniego, Raúl

; de la Vega, María Celina

; Civit, Emma

; González Lucero, Luciana

; Martire, María Victoria

; Aguila Maldonado, Rodrigo

; Gordon, Sergio

; Micelli, Marina

; Nieto, Romina

; Rausch, Gretel

; Gongora, Vanina

; Damico, Agustina

; Rodríguez Gil, Gustavo

; Dubinsky, Diana

; Orden, Alberto

; Zacariaz, Johana

; Romero, Julia

; Pera, Mariana

; Goñi, Mario

; Rillo, Oscar

; Báez, Roberto

; Arturi, Valeria

; González, Andrea

; Vivero, Florencia

; Bedoya, María Eugenia

; Shmid, María Marcela

; Caputo, Víctor

; Larroude, Maria Silvia

; Domínguez, Nadia

; Gómez, Graciela Noemí

; Rodríguez, Graciela Nora

; Marín, Josefina

; Collado, Victoria

; Jorfen, Marisa

; Bedran, Zaida

; Curti, Ana

; Gazzoni, María Victoria

; Sarano, Judith

; Zelaya, Marcos

; Sacnun, Mónica

; Finucci Curi, Pablo

; Rojas Tessel, Romina

; Arias Saavedra, Maira

; Sattler, María Emilia

; Machado Escobar, Maximiliano Augusto

; Astesana, Pablo

; Paris, Úrsula

; Virasoro, Belén María

; Santa Cruz, María Julia

; Allievi, Alberto

; Vandale, Juan Manuel

; Hojberg, Noelia Giselle

; Pons-Estel, Bernardo

; Pons-Estel, Guillermo

; García, Mercedes Argentina

Revista argentina de reumatología

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mar 2022, Volume 33 N. 1 Pages 14 - 25

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

resumen está disponible en el texto completo

Abstract Introduction: lupus is a complex disease and often difficult to approach. Achieving remission is one of the objectives, incorporating therapeutic options. Objectives: to describe the characteristics of the patients and the use of belimumab, according to the status of the disease. Materials and methods: cross-sectional study. Patients of the RELESSAR registry. Stratification: Remission: SLEDAI=0 and without corticosteroids. Low disease activity SLEDAI> 0 and ≤4 and without corticosteroids and non-optimal control: SLEDAI> 4 and any dose of corticosteroids. Results: a total of 1,277 patients were included, 23.4% in remission, 12.6% in low disease activity and 63.8% in non-optimal control. The last group was younger and had a shorter duration of the disease. They had higher activity and chronicity indices and greater use of immunosuppressants. Only 22.3% of the patients with potential criteria for the use of belimumab (activity disease despite standard treatment) were receiving it. The variables associated with hospitalizations were: corticosteroids, cyclophosphamide and higher SLICC. Those associated with severe infection: mycophenolate mofetil, azathioprine, corticosteroids, and higher SLICC. Conclusions: the complexity of the management of these patients is reflected, visualizing structural aspects such as inequality. The use of belimumab could be beneficial in selected patients.

https://doi.org/10.47196/rar.v33i1.602 101 downloads

Conversión de prueba cutánea de derivado proteico purificado durante el tratamiento con anti-TNF-α
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Abdala, Brian Marcelo

; Ringer, Ariana

; Ruffino, Juan Pablo

; Martínez, María Florencia

; Argento, María Cecilia

; Chulibert, Serenela

; Carbone, Daniela

; Lucci, Franco

; Gatica, Agostina

; Rombo, Graciela

; Palatnik, Mariano

; Cortese, María Noel

; Lagrutta, Mariana

; Finucci Curi, Baltasar

; Co, Adriana

; Abdala, Marcelo Alberto

Revista argentina de reumatología

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dec 2021, Volume 32 N. 4 Pages 21 - 27

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Introduction: anti-TNF-α are associated with an increased risk of developing tuberculosis (TB). Purified protein derivative (PPD) is used to demonstrate a latent TB infection (LTBI). Screening is recommended for TB prior to the onset of anti-TNF-α and monitoring evaluating possible conversion of PPD during treatment. Treatment of LTBI can reduce the risk of active disease development by up to 90%. Objectives: currently the results of PPD conversion and its interpretation during anti-TNF-α treatment are variable and that is why we set out to know the frequency of conversion of PPD in this group of patients in our environment. Materials and methods: a descriptive, analytical, observational, retrospective study was conducted. Including patients >18 years old, diagnosed with rheumatic disease, treated with anti-TNF-α. Results: 54 patients were included (46.7 ± to 12 years), of which 36 presented a diagnosis of rheumatoid arthritis, 6 juvenile idiopathic arthritis, 5 ankylosing spondylitis, 3 psoriatic arthritis, 3 uveitis, 1 interstitial keratitis. The treatments were: 30 adalimumab, 17 certolizumab, 7 etanercept, 44 methotrexate, 19 leflunomide, 9 hydroxychloroquine, 2 sulfasalazine, 2 azathioprine, 1 mycophenolate mofetil and glucocorticoids (28/54). PPD conversion took place in 1 patient. Conclusions: in the present study, seroconversion was low in contrast to other series. The PPD test is an accessible, widely available, adequate and sensitive method for diagnosing LTBI, which the rheumatologist should use in his daily practice.

Introducción: los anti-TNF-α se asocian con mayor riesgo de desarrollar tuberculosis (TB). La prueba del derivado proteico purificado (purified protein derivative, PPD) se emplea para diagnosticar infección de tuberculosis latente (ITL). Se recomienda el cribado para TB previo al inicio de terapia anti-TNF-α y el seguimiento para evaluar la posible conversión de la PPD durante el tratamiento. El tratamiento de la ITL puede reducir el riesgo de desarrollar enfermedad activa en un 90%. Objetivos: actualmente los resultados de conversión de la PPD y su interpretación durante el tratamiento anti-TNF-α son variables, por tal motivo nos propusimos conocer la frecuencia de conversión de la PPD en este grupo de pacientes de nuestro medio. Materiales y métodos: realizamos un estudio descriptivo, observacional y retrospectivo que incluyó pacientes >18 años, diagnosticados con enfermedad reumática, tratados con anti-TNF-α. Resultados: se incluyeron 54 pacientes (46,7 ± a 12 años), de los cuales 36, presentaron diagnóstico de artritis reumatoidea, seis de artritis idiopática juvenil, cinco de espondilitis anquilosante, tres de artritis psoriásica, tres de uveítis y uno de queratitis intersticial. Los tratamientos fueron: 30 adalimumab, 17 certolizumab, siete etanercept, 44 metotrexato, 19 leflunomida, nueve hidroxicloroquina, dos sulfasalazina, dos azatioprina, uno mofetil micofenolato y glucocorticoides (28 de 54); la conversión de la PPD ocurrió en un solo paciente. Conclusiones: en el presente trabajo la seroconversión fue baja en contraste con otras series. La prueba de PPD es un método accesible, ampliamente disponible, adecuado y sensible para diagnosticar ITL.

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Disfunción sexual en mujeres con lupus eritematoso sistémico
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Espasa, Gabriela Vanesa

; González Lucero, Luciana

; Soria Curi, Yessika Jackeline

; Mazza, Susana Marcela

; Leguizamón, María Lilia

; Pera, Mariana

; Barbaglia, Ana Lucía

; Sueldo, Héctor Raúl

; Bertolaccini, María Constanza

; Santana, Mirta

; Galindo, Liliana María

; Bellomio, Verónica Inés

Revista argentina de reumatología

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sep 2021, Volume 32 N. 3 Pages 9 - 14

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Introduction: sexual dysfunction is the alteration in one or several phases of sexual activity. It can culminate in frustration, pain and a decrease in the frequency of sexual intercourse. Objectives: determine the frequency of sexual dysfunction and analyze associated factors in patients with SLE. Materials and methods: a descriptive cross-sectional study was conducted. We included patients with SLE, between 18 and 50 years of age, Secondary Sjogren’s syndrome, menopause, severe depression and illiterate patients were excluded. Demographic and disease-related variables were studied. The Depression Anxiety Stress Scale (DASS-21), and the Female Sexual Function Index (FSFI) were applied. Results: sixty women with SLE and 63 controls were evaluated. The prevalence of SD in SLE was 71.7% and there were significant differences in all domains of sexual function. The total FSFI score in patients with SLE was lower when compared to controls. According to the DASS-21 scale, stress, anxiety and depression were observed in at least half of lupus women, however no association was found between these variables and SD. Conclusions: the prevalence of SD in patients with SLE was high. Depression, Anxiety, and Stress were not determinants in the presence of SD.

Introducción: la disfunción sexual (DS) es la alteración en una o varias de las fases de la actividad sexual. Puede culminar en frustración, dolor y disminución de la frecuencia de las relaciones sexuales. Objetivos: determinar la frecuencia de DS y analizar los factores asociados en pacientes con lupus eritematoso sistémico (LES). Materiales y métodos: se realizó un estudio de corte transversal. Se incluyeron pacientes femeninas con LES, entre 18 y 50 años, se excluyeron aquellas con síndrome de Sjögren, menopausia, depresión severa y analfabetas. Se evaluaron variables demográficas y de la enfermedad. Se aplicó la escala Depression Anxiety Stress Scale (DASS-21) y el Índice de Función Sexual Femenina (Female Sexual Function Index, FSFI). Se comparó con un grupo control sano. Resultados: se evaluaron 60 mujeres con LES y 63 controles. La prevalencia de DS en LES fue de 71,7% y hubo diferencias significativas en todos los dominios de la función sexual. El score total del FSFI en pacientes con LES fue menor al comparar con los controles. Según la escala DASS-21, estrés, ansiedad y depresión se observaron en al menos la mitad de mujeres lúpicas, sin embargo, no se encontró asociación entre estas variables y DS. Conclusiones: la prevalencia de DS en pacientes con LES fue elevada. Depresión, ansiedad y estrés no fueron determinantes en la presencia de DS.

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Macro scale analysis of Syrah vineyards under winter growing cycles: Agronomical and ecophysiological responses
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Brant, Luciana Alves Caldeira

; Souza, Cláudia Rita de

; Mota, Renata Vieira da

; Fernandes, Fernanda de Paula

; Gonçalves, Mariana Gabriele Marcolino

; Menezes, Michele Duarte de

; Peregrino, Isabela

; Curi, Nilton

; Regina, Murillo de Albuquerque

Scientia Agricola

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2021, Volume 78 N. 6 elocation e20200055

Abstract: En | Text: En | PDF: En

ABSTRACT: In Southeast Brazil, the change of grape harvest from wet summer to dry winter through double-pruning management has improved the quality of wines, currently denominated winter wines. In order to better understand the influences of soil, macroclimate, and vineyard management in winter wines, we investigated seven vineyards in the states of Minas Gerais (Três Corações – TC, Três Pontas – TP, Cordislândia – COR, São Sebastião do Paraíso – SSP and Andradas – AND) and São Paulo (Itobi – ITO and Espirito Santo do Pinhal – PIN) during three consecutive growing seasons. The vineyards are located in warm temperate zones and grouped in four soil types: Acrudox in TC, AND and SSP, Hapludox in TP; Hapludult in AND and PIN; Eutrudept in ITO. The high clay content (> 35 %) observed in all soil types, associated to low evapotranspiration demand, avoided the occurrence of severe water stress, as observed by the high values of leaf and stem water potential, stomatal conductance, photosynthesis, and transpiration. Differences in vigor were more related to vineyard management and did not affect grape composition. Among vineyards, parameters for berry quality from ITO, such as sugar and acidity, were more associated to high soil sand content and winter temperature. No significant differences were found in anthocyanins and total phenols of berries among vineyards, suggesting that the high thermal range and low precipitation during autumn-winter, historically observed in all municipalities, seemed to be the main factor for improvement of phenolic compounds.

https://doi.org/10.1590/1678-992x-2020-0055 798 downloads

Modeling and prediction of sulfuric acid digestion analyses data from PXRF spectrometry in tropical soils
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Silva, Sérgio Henrique Godinho

; Silva, Elen Alvarenga

; Poggere, Giovana Clarice

; Pádua Junior, Alceu Linares

; Gonçalves, Mariana Gabriele Marcolino

; Guilherme, Luiz Roberto Guimarães

; Curi, Nilton

Scientia Agricola

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2020, Volume 77 N. 4 elocation e20180132

Abstract: En | Text: En | PDF: En

ABSTRACT Sulfuric acid digestion analyses (SAD) provide useful information to environmental studies, in terms of the geochemical balance of nutrients, parent material uniformity, nutrient reserves for perennial crops, and mineralogical composition of the soil clay fraction. Yet, these analyses are costly, time consuming, and generate chemical waste. This work aimed at predicting SAD results from portable X-ray fluorescence (pXRF) spectrometry, which is proposed as a “green chemistry” alternative to the current SAD method. Soil samples developed from different parent materials were analyzed for soil texture and SAD, and scanned with pXRF. The SAD results were predicted from pXRF elemental analyses through simple linear regressions, stepwise multiple linear regressions, and random forest algorithm, with and without incorporation of soil texture data. The modeling was developed with 70 % of the data, while the remaining 30 % was used for validation through calculation of R2, adjusted R2, root mean square error, and mean error. Simple linear regression can accurately predict SAD results of Fe2O3 (R2 0.89), TiO2 (R2 0.96), and P2O5 (R2 0.89). Stepwise regressions provided accurate predictions for Al2O3 (R2 0.87) and Ki - molar weathering index (SiO2/Al2O3) (R2 0.74) by incorporating soil texture data, as well as for SiO2 (R2 0.61). Random forest also provided adequate predictions, especially for Fe2O3 (R2 0.95), and improved results of Kr - molar weathering index (SiO2/(Al2O3 + Fe2O3)) (R2 0.66), by incorporation of soil texture data. Our findings showed that the SAD results could be accurately predicted from pXRF data, decreasing costs, time and the production of laboratory waste.

https://doi.org/10.1590/1678-992x-2018-0132 968 downloads

Lateral loss of clay in the genesis of Luvisols in the Semi-Arid Depression of the Jequitinhonha Valley, Minas Gerais - Brazil
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Gonçalves, Mariana Gabriele Marcolino

; Ker, João Carlos

; Oliveira, Fábio Soares de

; Ramos, Letícia Onara Silva

; Pacheco, Anderson Almeida

; Curi, Nilton

Ciência e Agrotecnologia

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2019, Volume 43 elocation e0182

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Os solos da região semi-árida de Minas Gerais possuem pequena profundidade; consistência dura, muito dura ou mesmo extremamente dura quando seca e muito plástica e muito pegajosa quando úmida; estrutura colunar ou em blocos angulares e fendilhamento significativo ao longo do perfil no período seco, entretanto eles não foram profundamente estudados até agora. Assim, o objetivo deste estudo foi detalhar a gênese dos Luvissolos da Depressão Semi-árida do Vale do Jequitinhonha (MG), a partir de atributos morfológicos, físicos, químicos, micromorfológicos e mineralógicos, e suas relações. A ausência de cutãs de iluviação na análise micromorfológica em laboratório foi consistente com a fraca e pouca cerosidade observada no topo do horizonte B de apenas um dos quatro perfis de solo estudados durante os trabalhos de campo. Considerando a ocorrência de argilominerais 2:1 expansíveis, os quais podem facilmente modificar tal feição pedológica, cautela é recomendada com relação à interpretação da gênese do solo. Desta maneira, a perda lateral de argila dos horizontes superficiais é enfatizada como o principal processo de formação dos Luvissolos estudados. A capacidade de troca de cátions desses solos revelou valores diferencialmente mais baixos para Luvissolos em regiões semi-áridas brasileiras.

ABSTRACT Soils of the semi-arid region of Minas Gerais have small depth; hard, very hard or even extremely hard consistency when dry and very plastic and very sticky when moist; columnar or angular blocky structure and significant cracking along the profile in the dry period, however they have not been deeply studied yet. Thus, the aim of this study was to detail the genesis of Luvisols in the Semi-arid Depression of the Jequitinhonha Valley (MG), incompassing morphological, physical, chemical, micromorphological and mineralogical attributes, and their relationships. The lack of illuviation coatings in the micromorphological analysis is in line with the expressionless and unclear clay skins observed in the top of the B horizon in only one out of the four soil profiles during the field work. Considering the occurrence of expandable 2:1 clay minerals, which can easily modify such pedological feature, caution is recommended in relation to soil genesis interpretation. The lateral loss of the clay fraction from the superficial horizons is highlighted as the main formation process of the Luvisols studied. The cation exchange capacity of these soils revealed remarkable lower values for the Luvisols in semi-arid Brazilian regions.

https://doi.org/10.1590/1413-7054201943018219 699 downloads

Characterization and Marmelade processing potential of quince cultivars cultivated in tropical regions
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Curi, Paula Nogueira

; Coutinho, Givago

; Matos, Mariana

; Pio, Rafael

; Albergaria, Francielly Corrêa

; Souza, Vanessa Rios de

Revista Brasileira de Fruticultura

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2018, Volume 40 N. 2 elocation e-986

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Com o intuito de agregar valor ao produto final, e visando a identificar quais cultivares implantadas em regiões tropicais são mais apropriadas para o processamento de marmeladas, o objetivo deste estudo foi caracterizar e avaliar a influência de diferentes cultivares de marmeleiro (‘Fuller’, ‘Smyrna’, ‘Portugal’, ‘Provence’, ‘Mendonza Inta-37’, ‘Alaranjado’, ‘Lajeado’, ‘CTS 207’, ‘D’Angers’ e ‘Bereczy’), cultivados em regiões tropicais do Brasil, sobre as características físico-químicas, propriedades reológicas e aceitação sensorial da marmelada obtida. As diferentes cultivares de marmelo apresentaram grande variabilidade entre si em relação às características físicas e físico-químicas. Entretanto, as cultivares estudadas deram origem a marmeladas muito semelhantes entre si que apresentaram alta aceitação sensorial, com exceção da cultivar Mendonza Inta-37, que deu origem a uma marmelada menos aceita.

Abstract With the purpose of adding value to the final product and aiming to identify which cultivars implanted in tropical regions are more appropriate for the processing of marmelade, the objective of this study was to characterize and evaluate the influence of different cultivars of quince (‘Fuller’, ‘Smyrna’, ‘Portugal’, ‘Provence’, ‘Mendonza Inta-37’, ‘Alaranjado’, ‘Lajeado’, ‘CTS 207’, ‘D’Angers’ and ‘Bereczy’) grown in tropical Brazilian regions, on the physical-chemical characteristics, rheological properties and the consumer acceptance of the obtained marmelade. The different quince cultivars presented great variability among themselves in relation to physical and physicochemical characteristics. However, the cultivars studied gave rise to marmelades that were similar to each other, which had a high sensory acceptance, except for the cultivar Mendonza Inta-37, which resulted in a less accepted marmelade.

https://doi.org/10.1590/0100-29452018986 780 downloads

10.

MELANOMACRÓFAGOS HEPÁTICOS Y ACTIVIDAD DE LA ENZIMA GLUTATION S-TRANSFERASA EN Leptodactylus chaquensis (ANURA, LEPTODACTYLIDAE) COMO BIOMARCADORES DE ESTRÉS OXIDATIVO POR LA EXPOSICIÓN A CLORPIRIFOS
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HUESPE, Ivan

; CABAGNA-ZENKLUSEN, Mariana

; CURI, Lucila Marilén

; PELTZER, Paola

; ATTADEMO, Maximiliano Andrés

; VILLAFAÑE, Noelia

; LAJMANOVICH, Rafael

Acta Biológica Colombiana

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aug 2017, Volume 22 N. 2 Pages 234 - 237

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

RESUMEN Se cuantificaron y compararon los melanomacrófagos (MM) y la actividad de la enzima Glutatión S-Transferasa (GST) en hígados de ejemplares adultos de Leptodactylus chaquensis (Anura, Leptodactylidae) colectados en un cultivo de arroz (CA) (siete días posteriores a la aplicación de clorpirifos, CPF) y en un sitio de referencia (SR) en el departamento San Javier, provincia de Santa Fe (Argentina). El análisis histológico reveló una mayor cantidad (p = 0.028) y área ocupada por MM (p = 0.017) y se registró una inhibición en la actividad de la GST (p = 0.030) en individuos del CA respecto a los del SR. Los efectos descriptos evidencian el riesgo ecotoxicológico para los anuros en los cultivos de arroz con aplicaciones de CPF.

ABSTRACT We quantified and compared the hepatic melanomacrophage (MM) and glutathione S-transferase (GST) enzyme activity (two oxidative stress biomarkers) in the liver of Leptodatylus chaquensis adults (Anura, Leptodactylidae) collected in a rice field (CA) in San Javier department, Santa Fe (Argentina), seven days after the application of chlorpyrifos and in a reference site (SR). The histological analysis revealed a significant amount (p = 0.028) and area occupied by MM (p = 0.017) in livers of CA compared to SR. Furthermore, a significant inhibition of GST activity was recorded in the CA frogs compared to the SR (p = 0.030). The histopathological and enzymatic effects provide evidences of ecotoxicological risk for anurans in rice field with CPF application.

https://doi.org/10.15446/abc.v22n2.60823 803 downloads

11.

Uso turístico da mina subterránea Brasileira de Ouro de Passagem (MG)
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Miranda, José Fernando

; Curi, Adilson

Revista de Medio Ambiente y Mineria

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2017, N. 3 Pages 35 - 42

Abstract: Es Pt En | Text: Es Pt En | PDF: Es | PDF: Pt | PDF: En

Resumen: Brasil tuvo varios casos de cierre inadecuado de minas durante su historia. En las últimas décadas, sin embargo, los casos de restauración de las minas, incluyendo un nuevo uso del área, son frecuentes. La principal razón para ello ha sido una legislación más exigente y más actuante. Este artículo describe el caso de la restauración de la mina subterránea cerrada de Passagem en Mariana (MG) para su uso como una estructura de turismo histórico y de aventura. En este estudio de caso se contemplan seis áreas principales de impactos: Impacto en el ambiente físico, biológico y ecológico; impacto en los valores de uso alternativos del área; impacto en la calidad de vida; impacto en los valores culturales y sociales; impacto en el desarrollo económico y sostenible.

Abstract: Brazil has had several cases of inadequate closure of mines during its history. In the last decades, however, the cases of restoration of the mines, including a new use of the area, are frequent. The main reason for this has been more demanding and more active legislation. This article describes the case of restoration of the closed underground mine of Passage in Mariana (MG) for use as a structure of historical and adventure tourism. In this case study, six main areas of impacts are considered: Impact on the physical, biological and ecological environment, impact on alternative use values of the area; impact on quality of life; impact on cultural and social values; impact on economic and sustainable development.

97 downloads

12.

Validade e fidedignidade de uma escala de avaliação do apoio social para a atividade física
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Reis, Mariana Silva dos

; Reis, Rodrigo Siqueira

; Hallal, Pedro Curi

Revista de Saúde Pública

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apr 2011, Volume 45 N. 2 Pages 294 - 301

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

OBJETIVO: Avaliar a validade e a fidedignidade da versão brasileira da escala de apoio social para a prática de atividades físicas em adultos. MÉTODOS: A escala foi aplicada em conjunto com um questionário multidimensional face a face em 1.461 indivíduos com idade entre 18 e 79 anos residentes em Curitiba, PR, entre abril e julho de 2009. O questionário foi submetido à testagem de validade (fatorial e construto) e fidedignidade (consistência interna e reprodutibilidade). A fidedignidade foi verificada pela consistência interna, pelo alfa de Cronbach, pelo procedimento de teste-reteste com uma semana de intervalo (n = 74) e pelo coeficiente de correlação intraclasse. RESULTADOS: A análise fatorial resultou em quatro fatores com autovalores entre 4,29 e 1,39 que explicaram 82,8% da variância total. Nos fatores 1 e 2, ficaram agrupadas as questões sobre apoio social recebido dos amigos para atividades físicas moderadas a vigorosas e caminhada, respectivamente. Os fatores 3 e 4 foram constituídos dos agrupamentos do apoio social recebido da família, para atividades físicas moderadas a vigorosas e caminhada, respectivamente. A reprodutibilidade apresentou coeficiente de correlação intraclasse entre 0,63 e 0,80 e consistência interna alfa entre 0,87 e 0,91. A validade de construto foi constatada pela associação significativa (p < 0,005) entre os escores de apoio social com caminhada e atividades físicas moderadas a vigorosas. CONCLUSÕES: O instrumento testado apresentou características psicométricas adequadas para emprego em adultos brasileiros.

OBJECTIVE: To assess the validity and reliability of the Brazilian version of the physical activity social support scale for adults. METHODS: The scale was applied in conjunction with a face-to-face multi-dimensional questionnaire in 1,461 individuals aged between 18 and 79 years, living in Curitiba, Southeastern Brazil, between April and July 2009. The questionnaire was submitted to validity (factorial and construct) and reliability testing (internal consistency and reproducibility). Reliability was observed with the use of internal consistency, Cronbach's alpha, test-retest procedure with a one-week interval (n = 74) and intraclass correlation coefficient. RESULTS: Factorial analysis resulted in four factors with eigenvalues between 4.29 and 1.39, which explained 82.8% of the total variance. Factors 1 and 2 included questions about social support from friends for moderate to vigorous physical activities and walking, respectively. Factors 3 and 4 were comprised of groups of social support from the family for moderate to vigorous physical activities and walking, respectively. Reproducibility showed an intraclass correlation coefficient between 0.63 and 0.80 and alpha internal consistency between 0.87 and 0.91. Construct validity was observed from the significant association (p < 0.005) between scores of social support for walking and moderate to vigorous physical activities. CONCLUSIONS: The instrument tested showed psychometric characteristics that were adequate for use in adult Brazilians.

OBJETIVO: Evaluar la validez y la fidedignidad de la versión brasilera de la escala de apoyo social para la práctica de actividades físicas en adultos. MÉTODOS: La escala fue aplicada en conjunto con un cuestionario multidimensional cara a cara en 1.461 individuos con edad entre 18 y 79 años residentes en Curitiba, Sur de Brasil, entre abril y julio de 2009. El cuestionario fue sometido a evaluación de validez (factorial y constructo) y de fidedignidad (consistencia interna y reproductibilidad). La fidedignidad fue verificada por la consistencia interna, por el alfa de Cronbach, por el procedimiento de test-retest con una semana de intervalo (n=74) y por el coeficiente de correlación intraclase. RESULTADOS: El análisis factorial resultó en cuatro factores con autovalores entre 4,29 y 1,39 que explicaron 82,8% de la varianza total. En los factores 1 y 2, quedaron agrupadas las preguntas sobre apoyo social recibido de los amigos para actividades físicas moderadas a vigorosas y caminata, respectivamente. Los factores 3 y 4 fueron constituidos por los agrupamientos de apoyo social recibido de la familia, para actividades físicas moderadas a vigorosas y caminata, respectivamente. La reproductibilidad presentó coeficiente de correlación intraclase entre 0,63 y 0,80 y consistencia interna alfa entre 0,87 y 0,91. La validez del constructo fue constatada por la asociación significativa (p<0,005) entre los escores de apoyo social con caminata y actividades físicas moderadas a vigorosas. CONCLUSIONES: El instrumento testado presentó características psicométricas adecuadas para empleo en adultos brasileños.

2410 downloads

13.

Validade e fidedignidade de uma escala de avaliação do apoio social para a atividade física
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Reis, Mariana Silva dos

; Reis, Rodrigo Siqueira

; Hallal, Pedro Curi

Revista de Saúde Pública

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apr 2011, Volume 45 N. 2 Pages 294 - 301

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

9060 downloads

14.

Estudo prospectivo de 100 casos de "core" biópsia dirigida por ultra-som e revisão da literatura
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Melo, Ana Lúcia Kefalás Oliveira

; Barra, Maria Fernanda Curi

; Silva, Andreza Vargas da

; Oliveira, Mariana Kefalás

; Scandiuzzi, Délcio

; Menezes, Antônio Carlos

Radiologia Brasileira

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dec 2003, Volume 36 N. 6 Pages 339 - 344

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

OBJETIVO: Mostrar a eficácia do método para evitar biópsias excisionais, verificar suas dificuldades técnicas, definir entre seguimento e biópsia excisional nos nódulos categoria IV do BI-RADS™ e agilizar o procedimento cirúrgico nos casos de nódulos altamente suspeitos de malignidade (categoria V). MATERIAIS E MÉTODOS: As pacientes foram submetidas a exame clínico de rotina, mamografia e ultra-som. A "core" foi feita com pistola automática e agulha número 14, e foram colhidas de quatro a oito amostras. RESULTADOS: Das 100 lesões estudadas, 47 foram submetidas à cirurgia, além da "core", e diagnosticaram-se 34 carcinomas (34,0%). Das 23 lesões classificadas como categoria III, identificou-se apenas um carcinoma (4,34%); das 43 classificadas como categoria IV, sete (16,28%); e das 34 classificadas como categoria V, 26 (76,47%). Evitou-se a biópsia excisional em 53 casos (53,0%). Identificou-se dificuldade no método da "core" em sete casos (7,0%), devido a material insuficiente, risco para malignidade envolvendo lesões esclerosantes complexas e discordância entre imagem e histologia. As 33 lesões com resultados de malignidade à punção biópsia por agulha grossa foram confirmadas após a biópsia cirúrgica. Em um caso o diagnóstico pela "core" foi de hiperplasia ductal atípica e após a biópsia cirúrgica da peça diagnosticou-se carcinoma, correspondendo a um resultado falso-negativo. Não houve nenhum resultado falso-positivo.

OBJECTIVE: To demonstrate the efficacy of core-needle biopsy to avoid unnecessary surgery; to assess the technical difficulties of this method; to establish decision criteria for clinical follow-up or surgery in patients with lesions classified as suspicious for malignancy (BI-RADS IV); to expedite surgery in patients with lesions classified as highly suspicious for malignancy (BI-RADS V). MATERIALS AND METHODS: The patients were submitted to clinical examination, mammography and ultrasound. Core-needle biopsy was done using a 14-gauge needle, and 4-8 cores per lesion were obtained. RESULTS: A hundred lesions were studied, 47 of them underwent surgery and biopsy, and 34 cancers were diagnosed. In 23 lesions classified as probably benign (III) only one case of cancer was diagnosed (4.34%). In 43 lesions classified as IV, seven (16.28%) cancers were found whereas in 34 lesions classified as V, 26 (76.47%) cases of cancer were identified. It was possible to avoid surgery in 53 cases (53%). Difficulties in core-needle biopsy occurred in seven cases including insufficient material, risk of malignancy due to sclerosing lesions and lack of correlation between imaging and core-needle biopsy results. All the core biopsy diagnoses of malignancy were confirmed by surgery. There was one false negative result when the core biopsy specimen examination showed atypical hyperplasia while surgery specimen analysis revealed a carcinoma. There were no false positive cases.

10648 downloads

15.

Avaliação integrada do impacto do uso de agrotóxicos sobre a saúde humana em uma comunidade agrícola de Nova Friburgo, RJ
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Moreira, Josino C.

; Jacob, Silvana C.

; Peres, Frederico

; Lima, Jaime S.

; Meyer, Armando

; Oliveira-Silva, Jefferson J.

; Sarcinelli, Paula N.

; Batista, Darcilio F.

; Egler, Mariana

; Faria, Mauro V. Castro

; Araújo, Alberto José de

; Kubota, Alexandre H.

; Soares, Mônica de O.

; Alves, Sergio R.

; Moura, Cláudia M.

; Curi, Rosane

Ciência & Saúde Coletiva

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2002, Volume 7 N. 2 Pages 299 - 311

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O impacto do uso de agrotóxicos sobre a saúde humana é um problema que tem merecido atenção da comunidade científica em todo o mundo, sobretudo nos países em desenvolvimento. O consumo de agrotóxicos na região sudeste do Brasil está estimado em 12kg de agrotóxico/trabalhador/ano. Em algumas áreas agrícolas do Estado do Rio de Janeiro, como na região da Microbacia do Córrego de São Lourenço, Nova Friburgo, o consumo de agrotóxico foi estimado em 56kg de agrotóxico/trabalhador/ano. Elevados níveis de contaminação humana e ambiental foram encontrados nesta região, como decorrência do uso extensivo destes agentes químicos. A avaliação do impacto sobre a saúde humana implica o conhecimento e a visualização da importância/magnitude relativa de cada uma das vias de contaminação. Inúmeros fatores, que, em geral, encontram-se inter-relacionados, contribuem para a situação encontrada na Microbacia do Córrego de São Lourenço e a forma mais adequada de se avaliar toda a dimensão deste problema é o uso de uma abordagem integrada.

Environmental and human difficulties caused by pesticides used in agriculture are important health issues worldwide, specially in the developing countries. Pesticide consumption in Southeast Brazil is estimated in 12kg/worker/year. In the São Lourenço Valley, Rio de Janeiro State, pesticide consumption is estimated at some 56kg/worker/year. High levels of human and environmental contamination caused by these products were found in the area. Many factors were shown as determinants of this situation, such as: pesticides with different formulations used with insufficient or even non-existent supervision or technical advice; intensive marketing activities place the responsibility for correct use and disposal of these chemicals on farm workers with low education levels typical of rural areas in Brazil, resulting in widespread human and environmental contamination. The evaluation of those loosely inter-related factors help shape the current situation in the São Lourenço Valley, indicating that the only way to really understand and assess the problem as a whole is through an integrative (transdisciplinary) approach.

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