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Abstract In recent years, cold atmospheric plasma (CAP) is used for surface disinfection. However, little is known about its ability to improve biocompatibility of metallic surfaces when compared to thermal plasma methods. In this context, the study aimed to evaluate the response of human endothelial cells (Ea.hy926) on titanium surfaces treated by non-thermal plasma method and thermal plasma method under nitriding atmosphere. The wettability was characterized by the sessile drop method, the topography and roughness were evaluated by atomic force microscopy (AFM), and the microstructure by grazing angle X-ray diffraction (GIXRD). Endothelial cells were cultured and evaluated for morphology by scanning electron microscopy and viability by an MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) assay. CAP treatment reduced the contact angle of the Ti surface (13.43° ± 1.48; p<0.05), increasing hydrophilicity. Rz roughness was higher on the nitrided surface (220.44±20.30; p< 0.001) compared to the CAP treated surfaces (83.29 ± 11.61; p< 0.001) and polished (75.98 ±34.21a); p<0.001). The different applied plasma treatments created different titanium surfaces improving the biocompatibility of endothelial cells, however CAP results demonstrate its potential for biomedical applications, considering the low cost and ease of use of the technique, allowing surface treatments before clinical procedures.

https://doi.org/10.1590/0001-3765202320220865

Normal aortic diameters within the Mexican population and the impact of gender and ethnicity
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Fabiani, Mario A.

; González-Urquijo, Mauricio

; Silva-Platas, Christian

; Carrillo-Martínez, Miguel Á.

; Herrera-Vegas, Diego

; Morelli, Luis

; Vaquero-Puerta, Carlos

; Montero-Baker, Miguel

; Schonholtz, Claudio

; Hinojosa-González, David E.

; Mosquera-Anchorena, Nilo

; Reijnen, Michel

Revista mexicana de angiología

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sep 2022, Volume 50 N. 3 Pages 90 - 95

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Antecedentes: Faltan estudios que describan el tamaño normal de la aorta en población mexicana. Objetivos: Analizar las medidas aórticas en pacientes mexicanos y compararlas con pacientes de cinco países diferentes. Métodos: Las medidas de la aorta se dividieron en mexicanos y controles. Se realizó una comparación entre etnias y grupos mediante la prueba de suma de rangos de Mann Whitney. Resultados: El registro incluyó a 166 pacientes, 106 (63.8%) eran de México y 60 (36.1%) en el grupo control. Los pacientes mexicanos tenían diámetros aórticos más pequeños en comparación con el grupo control, a nivel del ostium de la arteria renal derecha, la arteria mesentérica inferior y la bifurcación aórtica. La población hispana tenía diámetros aórticos significativamente más pequeños desde el nivel de la arteria celíaca hasta la bifurcación aórtica. Conclusión: Los diámetros aórticos normales en la población mexicana son menores en comparación con otros países.

Abstract Background: There is a lack of studies describing the normal size of the aorta in Mexican population. Objective: To analyze aortic measurements in Mexican patients and to compared them with patients from five different countries. Methods: Measurements of the aorta were divided in Mexicans and controls. Comparisons between ethnicities and groups were performed using Mann Whitney rank sum test. Results: The registry included 166 patients, 106 (63.8%) were enrolled in Mexico and 60 (36.1%) in the control group. Mexican patients had smaller aortic diameters compared to the control group, at the level of the right renal artery ostium, inferior mesenteric artery, and aortic bifurcation. The Hispanic population had significantly smaller aortic diameters from the level of the celiac artery to the aortic bifurcation. Conclusion: The normal aortic diameters in the Mexican population are smaller compared to other countries.

https://doi.org/10.24875/rma.22000026 2 downloads

Valorization of Hesperidin from Citrus Residues: Evaluation of Microwave-Assisted Synthesis of Hesperidin-Mg Complex and Their Insecticidal Activity
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Silva, Danielle F. da

; Bomfim, João P. A.

; Marchi, Rafael C.

; Amaral, Jéssica C.

; Pinto, Luciano S.

; Carlos, Rose M.

; Ferreira, Antonio G.

; Forim, Moacir R.

; Fernandes, João B.

; Silva, Maria F. G. F. da

; Oliveira, Regiane C. de

; Buss, David

; Kirk, William D. J.

; Bruce, Toby J. A.

Journal of the Brazilian Chemical Society

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jul 2022, Volume 33 N. 7 Pages 772 - 782

Abstract: En | Text: En | PDF: En

The aim of the current study was the valorization of hesperidin, the dominant flavonoid in citrus processing waste, by microwave-assisted synthesis of hesperidin-Mg complex, improving its antioxidant activity and insecticidal potential. Here we show, for the first time, that microwave-assisted synthesis of [Mg(hesp)2(phen)]OAc (1) (hesp: hesperidin, phen: phenanthroline) improve the reaction rate and yield. The nuclear magnetic resonance (NMR) experiments proved to be powerful tools for the identification of three isomers in metal complexes. Moreover, we explore the insecticidal potential of 1 and [Mg(phen)2(Isov)]OAc (2) (Isov : isovanillic acid) complexes against three insects. Complex 1 killed 80% of adults whitefly at 0.14 μmol L-1, and 2 76% at 0.36 μmol L-1. There was a total mortality of Spodoptera frugiperda with 2 at 0.39 μmol L-1, and 83% with 1 at 0.14 μmol L-1. Both have similar activity, and represent a novel group of insecticide for Bemisia tabaci and S. frugiperda; nevertheless, the benefits of both as Myzus persicae repellent require further evaluation.

https://doi.org/10.21577/0103-5053.20220050

Synthesis and Anti-Chikungunya Virus (CHIKV) Activity of Novel 1,4-Naphthoquinone Sulfonamide and Sulfonate Ester Derivatives
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Pacheco, Paulo A. F.

; Gonzaga, Daniel T.

; Cirne-Santos, Cláudio C.

; Barros, Caroline S.

; Gomes, Max W. L.

; Gomes, Rafaela S. P.

; Gonçalves, Mariana C.

; Ferreira, Vitor F.

; Rabelo, Vitor W.

; Abreu, Paula A.

; Faria, Robson X.

; Resende, Gabriel O. de

; Rocha, David R. da

; Paixão, Izabel C. N. P.

; Silva, Fernando C. da

Journal of the Brazilian Chemical Society

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jun 2022, Volume 33 N. 6 Pages 556 - 569

Abstract: En | Text: En | PDF: En

Chikungunya virus (CHIKV) is a re-emerging disease caused by an alphavirus of the Togaviridae family. Since its first description in 1952, the disease has spread worldwide, affecting populations in both tropical and temperate countries. To date, there is no licensed vaccine or specific pharmacological treatment. Therefore, there is an increasing urgency in developing new antiviral drugs capable of specifically inhibiting viral replication. In the present work, we report the synthesis and antiviral activity evaluation of nineteen naphthoquinone derivatives, containing a sulfonamide or sulfonate group. Cell viability assays indicated a low toxic potential for all tested compounds and inhibitory assays against CHIKV identified five compounds with potent activity. The compounds were also evaluated for their virucidal potential, and the results demonstrated that compound 11a exhibited a virucidal effect higher than 70% in the treatment with 20 µM. Furthermore, in silico studies were performed to predict the antiviral drug targets.

https://doi.org/10.21577/0103-5053.20220010

Ablação Septal com Cateteres e Radiofrequência Guiada pela Ecocardiografia para Tratamento de Pacientes com Cardiomiopatia Hipertrófica Obstrutiva: Experiência Inicial
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Valdigem, Bruno P.

; Correia, Edileide B.

; Moreira, Dalmo A. R.

; Bihan, David Le

; Pinto, Ibraim Masciarelli Francisco

; Abizaid, Alexandre A. Cunha

; Andalaft, Rogério Braga

; Paladino Filho, Antonio Tito

; Silva, Halstead Alarcão Gomes Pereira da

; Viesi, Joao Henrique Zucco

Arquivos Brasileiros de Cardiologia

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may 2022, Volume 118 N. 5 Pages 861 - 872

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Fundamentos A cardiomiopatia hipertrófica (CMH) pode causar obstrução da via de saída do ventrículo esquerdo (VSVE) e ser responsável pelo surgimento de sintomas limitantes, como cansaço físico. Quando tais sintomas são refratários ao tratamento farmacológico, os tratamentos alternativos intervencionistas podem ser úteis, como a ablação septal por meio da infusão de álcool na artéria coronária ou por meio da miectomia cirúrgica. Recentemente, o uso de cateter de radiofrequência (RF) para ablação do septo endocárdico guiado por mapeamento eletroanatômico mostrou-se eficaz apesar da elevada incidência de bloqueio atrioventricular total. Uma alternativa seria a aplicação de radiofrequência no ponto de início do gradiente septal guiada pelo ecocardiograma transesofágico (ETE). O ecocardiograma é um método de imagem com elevada acurácia para determinação da anatomia septal. Objetivo Avaliar o efeito em longo prazo da ablação septal para alívio do gradiente ventrículo-arterial, utilizando o ETE para auxiliar no posicionamento do cateter na área de maior obstrução septal. Avaliar também os efeitos da ablação na classe funcional e parâmetros ecocardiográficos. Métodos Doze pacientes sintomáticos com obstrução da VSVE, refratários à terapia farmacológica, foram submetidos à ablação endocárdica septal com cateteres com ponta de 8 mm, cujo posicionamento foi orientado na região de maior obstrução com auxílio do ETE. Foram realizadas aplicações de radiofrequência (RF) termocontrolada e escalonadas sobre a área alvo. Após cada aplicação, o gradiente era reavaliado e nova aplicação era realizada de acordo com critério clínico. Foram avaliados os efeitos das aplicações de RF tanto para o gradiente em repouso como para o provocado por meio da manobra de Valsalva, e considerado o gradiente. As diferenças foram significativas quando o valor de p foi menor ou igual a 0,05. Resultados Observou-se que a redução da média dos gradientes máximos obtidos foi de 96,8±34,7 mmHg para 62,7±25,4 mmHg ao final de três meses do procedimento (p=0,0036). Após um ano, a média dos gradientes máximos obtidos foi de 36,1±23,8 mmHg (p=0,0001). O procedimento foi bem tolerado e não houve registro de bloqueio atrioventricular total e nem complicações graves. Conclusão A ablação septal guiada pelo ETE foi eficaz e segura, com resultados mantidos durante o período de seguimento clínico. É uma opção razoável para o tratamento intervencionista da obstrução da VSVE em CMH.

Abstract Background Hypertrophic cardiomyopathy (HCM) can cause obstruction in the left ventricular outflow tract (LVOT), and be responsible for the onset of limiting symptoms, such as tiredness. When such symptoms are refractory to pharmacological treatment, interventionist alternative therapies can be useful, such as septal ablation through the infusion of alcohol in the coronary artery or through myectomy. Recently, the use of a radiofrequency (RF) catheter for endocardial septal ablation guided by electroanatomic mapping has proven to be efficient, despite the high incidence of complete atrioventricular block. An alternative would be the application of RF at the beginning point of the septal gradient guided by the transesophageal echocardiography (TEE). The echocardiography is an imaging method with high accuracy to determine septal anatomy. Objective To assess the long term effect of septal ablation for the relief of ventricular-arterial gradient, using TEE to help place the catheter in the area of larger septal obstruction. Besides, to assess the effects of ablation on the functional class and echocardiographic parameters. Methods Twelve asymptomatic patients, with LVOT obstruction, refractory to pharmacological therapy, underwent endocardial septal ablation with 8mm-tip catheters, whose placement was oriented in the region of larger obstruction, assisted by the TEE. Temperature-controlled and staggered RF applications were performed. After each application, the gradient was reassessed and a new application was performed according to the clinical criterion. The effects of RF applications were assessed both for the gradient at rest and for that provoked by the Valsalva maneuver, and considering the gradient. The differences were significant when p-value was lower than or equal to 0.05. Results It was possible to observe that the mean reduction of the maximum gradients was from 96.8±34.7 mmHg to 62.7±25.4 mmHg three months after the procedure (p=0.0036). After one year, the mean of maximum gradient was 36.1±23.8 mmHg (p=0.0001). The procedure was well tolerated, without records of complete atrioventricular block nor severe complications. Conclusion The TEE-guided septal ablation was efficient and safe, and the results were maintained during the clinical follow-up period. It is a reasonable option for the interventionist treatment of LVOT obstruction in HCM.

https://doi.org/10.36660/abc.20200732

Manejo quirúrgico de perforaciones duodenales tras colangiopancreatografía retrógrada endoscópica: serie de casos
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Cabrera-Vargas, Luis F.

; Villarreal-Viana, Ricardo

; Pulido-Segura, Jean A.

; Pedraza-Ciro, Mauricio

; Santafe-Guerrero, Marcia

; Cabrera-Silva, Laura

; Acevedo-Fontalvo, David

Cirugía y cirujanos

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oct 2021, Volume 89 N. 5 Pages 611 - 617

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Antecedentes: Las complicaciones tras la colangiopancreatografía retrógrada endoscópica (CPRE) que necesitan manejo quirúrgico son limitadas y aproximadamente el 0.09-1.8% corresponden a perforación duodenal. Este tipo de lesiones requieren un diagnóstico temprano y un manejo adecuado, ya que los desenlaces pueden ser catastróficos, con una mortalidad reportada de hasta el 20%. Objetivo: Presentar nuestra experiencia en el manejo quirúrgico de estas lesiones. Método: Estudio observacional, retrospectivo y descriptivo, de pacientes que requirieron manejo quirúrgico por perforación duodenal tras CPRE en tres centros de Bogotá, Colombia, entre enero de 2013 y diciembre de 2018. Resultados: Fueron llevados a manejo quirúrgico 13 pacientes, 7 (53.8%) por vía laparoscópica, con una estancia hospitalaria promedio de 10.7 días y una mortalidad del 0%, y 6 (46.1%) por vía abierta, con una estancia hospitalaria promedio de 33 días y una mortalidad del 50%, con seguimiento mínimo a 6 meses. Conclusiones: La perforación duodenal tras una CPRE, pese a su baja incidencia, se debe sospechar por su alta morbimortalidad. La decisión del abordaje quirúrgico está condicionada por el estado clínico del paciente, y por ende está ligada al pronóstico de este.

Abstract Background: Complications after endoscopic retrograde cholangiopancreatography (ERCP) are rare, approximately 0.09% to 1.8% are duodenal perforation. This type of injury requires early diagnosis and proper management since the outcomes can be catastrophic, leading to death in 20% of cases. Objective: To show our experience in the management of these injuries in order to establish if there is benefit from minimally invasive management versus conventional management. Method: Observational, retrospective and descriptive study comparing patients who required surgical management after post-ERCP duodenal perforation in three centers in Bogotá, Colombia, between January 2013 and December 2018. Results: 13 patients were taken to surgical management after duodenal perforation post ERCP, 7 laparoscopically (53.8%), with an average hospital stay of 10.7 days and mortality of 0% and 6 by open route (46.1%), with an average hospital stay of 33 days and mortality of 50%, with a minimum follow-up of 6 months. Conclusions: Post ERCP duodenal perforation, despite its low incidence, should be suspected due to its high mortality. Laparoscopic surgery is a good tool to address duodenal perforations after ERCP, because it presents a lower rate of complications and mortality.

https://doi.org/10.24875/ciru.20000819

Differences in children and adolescents with SARS-CoV-2 infection: a cohort study in a Brazilian tertiary referral hospital
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Marques, Heloisa Helena de Sousa

; Pereira, Maria Fernanda Badue

; Santos, Angélica Carreira dos

; Fink, Thais Toledo

; Paula, Camila Sanson Yoshino de

; Litvinov, Nadia

; Schvartsman, Claudio

; Delgado, Artur Figueiredo

; Gibelli, Maria Augusta Bento Cicaroni

; Carvalho, Werther Brunow de

; Odone Filho, Vicente

; Tannuri, Uenis

; Carneiro-Sampaio, Magda

; Grisi, Sandra

; Duarte, Alberto José da Silva

; Antonangelo, Leila

; Francisco, Rossana Pucineli Vieira

; Okay, Thelma Suely

; Batisttella, Linamara Rizzo

; Carvalho, Carlos Roberto Ribeiro de

; Brentani, Alexandra Valéria Maria

; Silva, Clovis Artur

; Eisencraft, Adriana Pasmanik

; Rossi Junior, Alfio

; Fante, Alice Lima

; Cora, Aline Pivetta

; Reis, Amelia Gorete A. de Costa

; Ferrer, Ana Paula Scoleze

; Andrade, Anarella Penha Meirelles de

; Watanabe, Andreia

; Gonçalves, Angelina Maria Freire

; Waetge, Aurora Rosaria Pagliara

; Silva, Camila Altenfelder

; Ceneviva, Carina

; Lazari, Carolina dos Santos

; Abellan, Deipara Monteiro

; Santos, Emilly Henrique dos

; Sabino, Ester Cerdeira

; Bianchini, Fabíola Roberta Marim

; Alcantara, Flávio Ferraz de Paes

; Ramos, Gabriel Frizzo

; Leal, Gabriela Nunes

; Rodriguez, Isadora Souza

; Pinho, João Renato Rebello

; Carneiro, Jorge David Avaizoglou

; Paz, Jose Albino

; Ferreira, Juliana Carvalho

; Ferranti, Juliana Ferreira

; Ferreira, Juliana de Oliveira Achili

; Framil, Juliana Valéria de Souza

; Silva, Katia Regina da

; Kanunfre, Kelly Aparecida

; Bastos, Karina Lucio de Medeiros

; Galleti, Karine Vusberg

; Cristofani, Lilian Maria

; Suzuki, Lisa

; Campos, Lucia Maria Arruda

; Perondi, Maria Beatriz de Moliterno

; Diniz, Maria de Fatima Rodrigues

; Fonseca, Maria Fernanda Mota

; Cordon, Mariana Nutti de Almeida

; Pissolato, Mariana

; Peres, Marina Silva

; Garanito, Marlene Pereira

; Imamura, Marta

; Dorna, Mayra de Barros

; Luglio, Michele

; Rocha, Mussya Cisotto

; Aikawa, Nadia Emi

; Degaspare, Natalia Viu

; Sakita, Neusa Keico

; Udsen, Nicole Lee

; Scudeller, Paula Gobi

; Gaiolla, Paula Vieira de Vincenzi

; Severini, Rafael da Silva Giannasi

; Rodrigues, Regina Maria

; Toma, Ricardo Katsuya

; Paula, Ricardo Iunis Citrangulo de

; Palmeira, Patricia

; Forsait, Silvana

; Farhat, Sylvia Costa Lima

; Sakano, Tânia Miyuki Shimoda

; Koch, Vera Hermina Kalika

; Cobello Junior, Vilson

Clinics

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2021, Volume 76 elocation e3488

Abstract: En | Text: En | PDF: En

OBJECTIVES: To compare demographic/clinical/laboratory/treatments and outcomes among children and adolescents with laboratory-confirmed coronavirus disease 2019 (COVID-19). METHODS: This was a cross-sectional study that included patients diagnosed with pediatric COVID-19 (aged <18 years) between April 11, 2020 and April 22, 2021. During this period, 102/5,951 (1.7%) of all admissions occurred in neonates, children, and adolescents. Furthermore, 3,962 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection samples were processed in patients aged <18 years, and laboratory-confirmed COVID-19 occurred in 155 (4%) inpatients and outpatients. Six/155 pediatric patients were excluded from the study. Therefore, the final group included 149 children and adolescents (n=97 inpatients and 52 outpatients) with positive SARS-CoV-2 results. RESULTS: The frequencies of sore throat, anosmia, dysgeusia, headache, myalgia, nausea, lymphopenia, pre-existing chronic conditions, immunosuppressive conditions, and autoimmune diseases were significantly reduced in children and adolescents (p<0.05). Likewise, the frequencies of enoxaparin use (p=0.037), current immunosuppressant use (p=0.008), vasoactive agents (p=0.045), arterial hypotension (p<0.001), and shock (p=0.024) were significantly lower in children than in adolescents. Logistic regression analysis showed that adolescents with laboratory-confirmed COVID-19 had increased odds ratios (ORs) for sore throat (OR 13.054; 95% confidence interval [CI] 2.750-61.977; p=0.001), nausea (OR 8.875; 95% CI 1.660-47.446; p=0.011), and lymphopenia (OR 3.575; 95% CI 1.355-9.430; p=0.010), but also had less hospitalizations (OR 0.355; 95% CI 0.138-0.916; p=0.032). The additional logistic regression analysis on patients with preexisting chronic conditions (n=108) showed that death as an outcome was significantly associated with pediatric severe acute respiratory syndrome (SARS) (OR 22.300; 95% CI 2.341-212.421; p=0.007) and multisystem inflammatory syndrome in children (MIS-C) (OR 11.261; 95% CI 1.189-106. 581; p=0.035). CONCLUSIONS: Half of the laboratory-confirmed COVID-19 cases occurred in adolescents. Individuals belonging to this age group had an acute systemic involvement of SARS-CoV-2 infection. Pediatric SARS and MIS-C were the most important factors associated with the mortality rate in pediatric chronic conditions with COVID-19.

https://doi.org/10.6061/clinics/2021/e3488

Consenso de hemofilia en México
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López-Arroyo, José L.

; Pérez-Zúñiga, Juan M.

; Merino-Pasaye, Laura E.

; Saavedra-González, Azucena

; Alcivar-Cedeño, Luisa María

; Álvarez-Vera, José Luis

; Anaya-Cuellar, Irene

; Arana-Luna, Luara L.

; Ávila-Castro, David

; Bates-Martín, Ramón A.

; Cesarman-Maus, Gabriela

; Chávez-Aguilar, Lénica A.

; Peña-Celaya, José A. de la

; Espitia-Ríos, María E.

; Estrada-Domínguez, Patricia

; Fermín-Caminero, Denisse

; Flores-Patricio, Willy

; García Chávez, Jaime

; García-Lee, María T.

; González-Pérez, María del Carmen

; González-Rubio, María del Carmen

; González-Villareal, María Guadalupe

; Ramírez-Moreno, Fabiola

; Hernández-Colin, Ana K.

; Hernández-Ruiz, Eleazar

; Herrera-Olivares, Wilfrido

; Leyto-Cruz, Faustino

; Loera-Fragoso, Sergio

; Martínez-Ríos, Annel

; Miranda-Madrazo, María R.

; Morales-Hernández, Alba

; Nava-Villegas, Lorena

; Orellana-Garibay, Juan J.

; Palma-Moreno, Orlando G.

; Paredes-Lozano, Eugenia P.

; Peña-Alcántara, Paula

; Pérez-Lozano, Uendy

; Pichardo-Cepín, Yayra M.

; Reynoso-Pérez, Ana Carolina

; Rodríguez-Serna, Mishel

; Rojas-Castillejos, Flavio

; Romero-Rodelo, Hilda

; Ruíz-Contreras, Josué I.

; Segura-García, Adela

; Silva-Vera, Karina

; Soto-Cisneros, Paulina M.

; Tapia-Enríquez, Ana L.

; Tavera-Rodríguez, Martha G.

; Teomitzi-Sánchez, Óscar

; Tepepa-Flores, Fredy

; Valencia-Rivas, María D.

; Valle-Cárdenas, Teresa

; Varela-Constantino, Ana

; Javier-Morales, Adrián

; Martínez-Ramírez, Mario A.

; Tena-Cano, Sergio

; Terrazas-Marín, Ricardo

; Vilchis-González, Shendel P.

; Villela-Peña, Atenas

; Mena-Zepeda, Verónica

; Alvarado Ibarra, Martha

Gaceta médica de México

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2021, Volume 157 Suppl. 1 Pages S1 - S37

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract Hemophilia is a hemorrhagic disorder with a sex-linked inherited pattern, characterized by an inability to amplify coagulation due to a deficiency in coagulation factor VIII (hemophilia A or classic) or factor IX (hemophilia B). Sequencing of the genes involved in hemophilia has provided a description and record of the main mutations, as well as a correlation with the various degrees of severity. Hemorrhagic manifestations are related to levels of circulating factor, mainly affecting the musculoskeletal system and specifically the large joints (knees, ankles and elbows). This document is a review and consensus of the main genetic aspects of hemophilia, from the inheritance pattern to the concept of women carriers, physiopathology and classification of the disorder, the basic and confirmation studies when hemophilia is suspected, the various treatment regimens based on infusion of the deficient coagulation factor as well as innovative factor-free therapies and recommendations for the management of complications associated with treatment (development of inhibitors and/or transfusion transmitted infections) or secondary to articular hemorrhagic events (hemophilic arthropathy). Finally, relevant reviews of clinical and treatment aspects of hemorrhagic pathology charachterized by acquired deficiency of FVIII secondary to neutralized antibodies named acquired hemophilia.

resumen está disponible en el texto completo

https://doi.org/10.24875/gmm.m20000451 305 downloads

Spontaneous poisoning by Cestrum intermedium in dairy cattle
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Pohl, Camila B.

; Hammerschmitt, Márcia E.

; Molossi, Franciéli A.

; Lorenzett, Marina P.

; Bianchi, Ronaldo M.

; Vignoli-Silva, Márcia

; Bianchetti, Samuel

; Panziera, Welden

; Barros, Claudio S.L.

; Pavarini, Saulo P.

; Driemeier, David

Pesquisa Veterinária Brasileira

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2021, Volume 41 elocation e06882

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: Intoxicações por plantas que causam hepatotoxicidade aguda são responsáveis por prejuízos econômicos em animais de produção no Brasil. Relatos de intoxicações naturais por Cestrum intermedium em bovinos não são comumente descritos no Rio Grande do Sul (RS). Este trabalho teve como objetivo documentar um surto de intoxicação espontânea por C. intermedium em bovinos leiteiros ocorrido na região Centro-Oriental do RS. Três bovinos com nove meses de idade, das raças Holandês e Jersey, foram acometidos depois de serem introduzidos em um pequeno piquete com escassez de forragem. Nessa área foram observados exemplares de Cestrum intermedium Sendtn com sinais de consumo. As taxas de morbidade e letalidade foram de 100% e os cursos clínicos variaram de 9 a 12 horas. Na necropsia dos três bovinos, observou-se predomínio de lesões hepáticas agudas. O fígado dos animais acometidos estava moderadamente aumentado de tamanho e na superfície de corte havia marcada acentuação do padrão lobular e hemorragia. Na abertura do rúmen, foram observadas folhas de Cestrum intermedium Sendtn parcialmente digeridas. Histologicamente, o fígado apresentava necrose coagulativa centrolobular e hemorragia. Frequentemente, essas alterações se estendiam para a região mediozonal. Foi realizada a técnica de imuno-histoquímica, na qual utilizou-se o anticorpo policlonal caspase 3 em fragmentos de fígado. Notou-se marcação moderada a acentuada em citoplasma e núcleo de hepatócitos, predominantemente na periferia das áreas de necrose hepática indicando apoptose celular. O diagnóstico de intoxicação por Cestrum intermedium Sendtn nos bovinos leiteiros desse estudo, foi realizado com base nos achados epidemiológicos, clínicos e anatomopatológicos. A intoxicação por C. intermedium é incomum em bovinos leiteiros, sendo descrita pela primeira vez na região centro oriental do RS e representa um diagnóstico diferencial de outras hepatopatias tóxicas agudas.

ABSTRACT: Acute hepatotoxicity caused by plants poisoning is responsible for economic losses in farm animals in Brazil. Reports of Cestrum intermedium natural poisoning in cattle are not commonly described in Rio Grande do Sul (RS). This study aimed to document an outbreak of spontaneous C. intermedium poisoning in dairy cattle in the Central-Eastern Mesoregion of RS. Three nine-month-old Holstein and Jersey heifers were affected after they were placed in a small paddock with shortage forage. In this area, specimens of C. intermedium Sendtn with signs of consumption were observed. Morbidity and lethality rates were 100% and clinical courses ranged from 9 to 12 hours. At post mortem examination of the three heifers, there was predominance of acute liver lesions. The liver was moderately enlarged and on the cut surface there was a marked accentuation of the lobular pattern and hemorrhage. Inside the rumen, partially digested C. intermedium Sendtn leaves were observed. The histological aspects of the liver were mostly centrilobular coagulative necrosis and hemorrhage, frequently extended to the midzonal region. The immunohistochemistry technique was performed, in which the polyclonal antibody caspase 3 was used in liver fragments. Moderate to marked immunolabeling was observed in the cytoplasm and nucleus of hepatocytes, predominantly on the periphery of areas of hepatic necrosis indicating cell apoptosis. The diagnosis of C. intermedium Sendtn poisoning in dairy cattle in this study was based on epidemiological, clinical and anatomopathological findings. Since the C. intermedium poisoning is uncommon in dairy cattle, we are describing it for the first time in the Central-Eastern Mesoregion of RS, and represents a differential diagnosis of other acute toxic liver diseases in cattle.

https://doi.org/10.1590/1678-5150-pvb-6882 117 downloads

10.

Effects of the incorporation of residue of masonry on the properties of cementitious mortars
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Silva, Yimmy Fernando

; Lange, David A.

; Delvasto, Silvio

Revista de la construcción

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dec 2020, Volume 19 N. 3 Pages 407 - 421

Abstract: En | Text: En | PDF: En

Abstract This research presents the results of an experimental study about the potentiality of using residues of masonry (RM), sampled from construction and demolition waste (CDW), as supplementary cementitious material (SCM). The Portland cement was partially replaced by RM up to 50% in weight (0%, 12.5%, 25%, 37.5% and 50%). Various tests were carried out for: pozzolanic activity (fixed lime and strength activity index), the heat of hydration, setting time, the (autogenous and by drying) shrinkage, and compressive strength. Experimental results shown that the RM has a positive activity because the increase of RM replacement level in the mortars generates a lower heat of hydration and autogenous and drying shrinkage. The fixed lime test at 28 and 180 days, indicated that the RM exhibits pozzolanic activity to some degree, and the Strength Activity Index (SAI) according to ASTM C311, was 77.13% and 84.36% at 7 and 28 days, respectively. These results indicate that RM should be considered appropriate for using as supplementary cementitious material.

https://doi.org/10.7764/rdlc.19.3.407 59 downloads

11.

Physiological quality of maize seeds produced under soil water deficit conditions
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Machado, Fernando H. B.

; David, Andréia M. S. de S.

; Santos, Silvânio R. dos

; Figueiredo, Josiane C.

; Silva, Cleisson D. da

; Nobre, Danúbia A. C.

Revista Brasileira de Engenharia Agrícola e Ambiental

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jul 2020, Volume 24 N. 7 Pages 451 - 456

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Em região semiárida as estratégias de cultivo que visem o uso racional da água devem ser aplicadas. Neste sentido, objetivou-se avaliar a qualidade fisiológica de sementes de milho produzidas sob limitações de água no solo. Foram estabelecidas cinco reposições de água no solo, baseadas na capacidade de campo (100, 85, 70, 55 e 40%), proporcionando condições controladas de água para dois híbridos de milho (2B 587 e DKB 390). O delineamento experimental utilizado foi em blocos casualizados em esquema de parcelas subdivididas, com quatro repetições, ficando as reposições de água nas parcelas e os híbridos nas subparcelas. Após a colheita das sementes determinaram-se o teor de água, a germinação e o vigor (primeira contagem de germinação, emergência de plântulas, índice de velocidade de germinação, comprimento de plântulas, envelhecimento acelerado, condutividade elétrica e teste de frio modificado). Para os híbridos em condições de restrição hídrica, o DKB 390 expressou melhor potencial fisiológico. Lâminas de reposição inferior a 70% da capacidade de campo, viabilizou a redução de água no solo e afetou negativamente a qualidade fisiológica das sementes de milho produzidas.

ABSTRACT Crop strategies focused on the rational use of water are required in semiarid regions. Thus, the objective of this work was to evaluate the physiological quality of maize seeds produced under soil water deficit conditions. Five irrigation water depth were established, based on the field capacity (100, 85, 70, 55 and 40%), to control the available water for two maize hybrids (2B-587 and DKB-390). A randomized block design was used, with a split-plot arrangement and four repetitions. The plots consisted of irrigation water depths, and the subplots consisted of maize hybrids. The seed water concentration, germination, and vigor were determined after the harvest, using data from first germination counting, seedling emergence, germination speed index, seedling length, and accelerated aging, electrical conductivity, and modified cold tests. The maize hybrid DKB-390 showed better physiological potential under the soil water deficit conditions evaluated. The irrigation water depths lower than 70% of field capacity resulted in decreases in soil water contents and affected negatively the physiological quality of the maize seeds produced.

https://doi.org/10.1590/1807-1929/agriambi.v24n7p451-456 583 downloads

12.

Aceites esenciales de plantas nativas del Perú: Efecto del lugar de cultivo en las características fisicoquímicas y actividad antioxidante
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Castro-Alayo, Efraín M.

; Chávez-Quintana, Segundo G.

; Auquiñivín-Silva, Erick A.

; Fernández-Jeri, Armstrong B.

; Cruz, Otilia Acha-De la

; Rodríguez-Hamamura, Nadia

; Olivas-Orozco, Guadalupe Isela

; Sepúlveda-Ahumada, David Roberto

Scientia Agropecuaria

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oct 2019, Volume 10 N. 4 Pages 479 - 487

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Essential oils (AE) are used as preservatives in the food industry, due to their physicochemical characteristics and antioxidant activity. The aim of this research was to determine yield (R), specific gravity (GE), refractive index (IR), antioxidant activity (AA) and chemical composition of AE of huacatay (Tagetes minuta), poleo (Minthostachys mollis), rosemary (Rosmarinus officinalis L.) and sachaculantro (Eryngium foetidum L.), plants collected from 52 districts of the Amazon region, Peru. For each AE, fixed-effect variance analysis was used with three replications and cluster analysis. The antioxidant activity was determined with the free radical method 2,2-diphenyl-1-picrylhydracil (DPPH) and its most abundant components were identified with headspace gas chromatography coupled to mass spectrometry. The differences in R, GE and IR were significant between districts. The AA showed no significant difference between the districts, but between the plants itself. Among the most abundant volatile components, 1-adamantanol (44.42%) was identified in huacatay, β-phellandrene (20.85%) in poleo, β-myrcene (34.59%) in rosemary and α-pinene (23.41%) in sachaculantro. It is concluded that the geographic location significantly affects the physicochemical properties of AE

Los aceites esenciales (AE) son usados como conservantes en la industria de alimentos, debido a sus características fisicoquímicas y actividad antioxidante. El objetivo de esta investigación fue determinar rendimiento (R), gravedad específica (GE), índice de refracción (IR), actividad antioxidante (AA) y composición química de AE de huacatay (Tagetes minuta), poleo (Minthostachys mollis), romero (Rosmarinus officinalis L.) y sachaculantro (Eryngium foetidum L.), plantas recolectadas de 52 distritos de la región Amazonas, Perú. Para cada AE se usó análisis de varianza de efectos fijos con tres repeticiones y análisis de clúster. La actividad antioxidante se determinó con el método del radical libre 2,2-difenil-1-picrilhidracilo (DPPH) y sus componentes más abundantes fueron identificados con cromatografía de gases acoplada a espectrometría de masas. Las diferencias en R, GE e IR fueron significativas entre distritos. La AA no mostró diferencia significativa entre los distritos, pero entre las plantas sí. Entre los componentes volátiles más abundantes se identificó 1-adamantanol (44,42%) en huacatay, β-felandreno (20,85%) en poleo, β-mirceno (34,59%) en romero y α-pineno (23,41%) en sachaculantro. Se concluye que el lugar geográfico afecta significativamente las propiedades fisicoquímicas de los AE

https://doi.org/10.17268/sci.agropecu.2019.04.04

13.

WIND EFFECTS ON FOUNDATIONS OF SILOS AND LIGHT STRUCTURES: SOLUTION BY USE OF STEEL PILES IN DIABASIC SOIL
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Carvalho, David de

; Fujii, Armando K.

; Paschoalin Filho, João A.

; Cury Filho, Dirney

; Silva, Marccella B. M.

Engenharia Agrícola

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jun 2019, Volume 39 N. 3 Pages 370 - 379

Abstract: En | Text: En | PDF: En

ABSTRACT Wind solicitations generate horizontal, tensile, and compressive stresses on building foundations. In empty light structures, such as agricultural greenhouses and, in the specific case of silos and elevated structures such as metal water tanks, the consideration of these loads becomes important because the lack of the weight component due to the storage load significantly influences the balance of forces. This study focused on the behavior of metallic steel profiles, aiming at its application as a foundation element for the pile, considering the soil of Diabasic origin common to the Center-South region of Brazil. Load tests in real scale were carried out on three steel profiles, type I, gauge W 250 mm x 32.7 kg m-1, drilled in the ground up to 12m deep by means of a pile driver. One steel profile was submitted to lateral loading, another to vertical compressive loading, and the other to vertical tensile load. Test results determined the bearing load of the pile for each loading type, calculated the soil reaction coefficient for lateral loading, and verified the applicability of load capacity prediction methods to tensile and compressive strengths of piles, commonly used in foundation projects.

https://doi.org/10.1590/1809-4430-eng.agric.v39n3p370-379/2019 1770 downloads

14.

Synthesis and Cytotoxicity Evaluation of a Series of 3-Alkenyl-2-Hydroxy-1,4-Naphthoquinones Obtained by an Efficient Knoevenagel Condensation
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David, Cibelle C.

; Lins, Antonio C. S.

; Silva, Tania M. S.

; Campos, Júlia F.

; Silva, Teresinha G.

; Militão, Gardenia C. G.

; Camara, Celso A.

Journal of the Brazilian Chemical Society

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jan 2019, Volume 30 N. 1 Pages 8 - 18

Abstract: En | Text: En | PDF: En

A modified and efficient Knoevenagel condensation procedure was developed to synthesize the title compounds using β-alanine and acetic acid as catalysts, showing good to excellent yields. We used lawsone with suitable aliphatic aldehydes including isobutyraldehyde, 3-methyl-butyraldehyde, 2-ethylbutyraldehyde, phenylacetaldehyde, 2-phenyl-propionaldehyde, among others. These compounds were submitted to cytotoxic screening against three tumor cell lines presenting good to excellent cytotoxic profiles.

https://doi.org/10.21577/0103-5053.20180146 941 downloads

15.

The urban and rural capybaras (Hydrochoerus hydrochaeris) as reservoir of Salmonella in the western Amazon, Brazil
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Farikoski, Itacir O.

; Medeiros, Luciana S.

; Carvalho, Yuri K.

; Ashford, David A.

; Figueiredo, Eduardo E. S.

; Fernandes, Dandara V.G.S.

; Silva, Paula J.B.

; Ribeiro, Vânia M.F.

Pesquisa Veterinária Brasileira

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jan 2019, Volume 39 N. 1 Pages 66 - 69

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: A capivara (Hydrochoerus hydrochaeris) é o maior roedor do mundo. No estado do Acre, Brasil, as populações de capivaras têm aumentado significativamente. O papel das capivaras na transmissão de certas infecções zoonóticas bacterianas não é bem compreendido, incluindo as bactérias do gênero Salmonella. Salmonella spp. geralmente causam enterite ou septicemia em mamíferos, porém muitas espécies de mamíferos podem carregar a bactéria de forma assintomática e eliminá-la em suas fezes. Para entender melhor o possível papel das capivaras como reservatórios de Salmonellaspp., realizamos um estudo para identificação de Salmonella spp. em amostras fecais de capivaras no Acre. Em uma amostra de conveniência, 54 capivaras de duas áreas urbanas e duas áreas rurais do Acre foram capturadas e mantidas por três a quatro dias para amostragem. Nenhum dos animais era sintomático de qualquer doença intestinal. Três amostras fecais foram coletadas de cada animal, durante sua permanência em cativeiro. Cada amostra foi cultivada para a presença de Salmonella spp. no Laboratório de Bacteriologia Veterinária da Universidade Federal do Acre. As amostras foram semeadas em caldo de pré-enriquecimento tetrationato e em peptona de caldo de pré-enriquecimento. Após 24 horas de incubação, todas as amostras foram semeadas em ágar MacConkey (MC) e ágar Salmonella-Shigella (SS). Colônias sugestivas foram submetidas a análises bioquímicas. Colônias compatíveis com Salmonella de acordo com o perfil bioquímico foram submetidas à sorotipagem (Sorokit para Salmonella - Probac do Brasil). Além disso, a primeira amostra de cada uma das 54 capivaras foi testada para Salmonella spp. usando PCR, visando gene hilA. Oito (5%) das 162 amostras examinadas por cultura bacteriana foram positivas para Salmonella spp. Enquanto quatro (7%) das 54 examinadas pela PCR foram positivas. Dos oito animais positivos em cultura, cinco eram de área urbana e três de área rural. Na PCR, apenas um animal positivo era de área urbana e quatro de área rural. Considerando o diagnóstico conjunto por ambos os testes, PCR e cultura, um animal foi considerado positivo. Todas as amostras foram coletadas em animais livres, sem sinais clínicos aparentes de salmonelose, indicando o potencial da capivara como reservatório nesse ecossistema.

ABSTRACT: The capybara (Hydrochoerus hydrochaeris) is the largest rodent in the world. In the state of Acre, Brazil, populations of capybaras have been increasing significantly. The role of capybaras in the transmission of certain bacterial zoonotic infections is not well understood, including bacteria of the genus Salmonella. Salmonella spp. generally cause enteritis or septicemia in mammals, however many mammalian species can carry the bacteria asymptomatically and shed it in their feces. To better understand the possible role of capybaras as reservoirs of Salmonella spp., we conducted a study of Salmonella within fecal samples from capybara in Acre. In a convenience sample, 54 capybaras from two urban and two rural areas of Acre were captured and kept for three to four days for sampling. None of the animals were symptomatic of any intestinal illness. Three separate fecal samples were collected from each animal, during their stays in captivity. Each sample was cultured for the presence of Salmonella spp. at the bacteriology laboratory of the Veterinary College of the Federal University of Acre. Samples were seeded in tetrationate pre-enrichment broth and in pre-enrichment broth peptone. After a 24 hour of incubation all samples were streaked on MacConkey Agar (MC) and Salmonella-Shigella Agar (SS). Suggestive colonies were submitted to biochemical analysis. Salmonella compatible colonies according to biochemical profile were submitted to serotyping (Sorokit for Salmonella - Probac do Brasil). In addition, the first sample from each of the 54 capybara was tested for Salmonella spp. using PCR targeting gene hilA. Eight (5%) of the 162 samples examined by bacterial culture were positive for Salmonella spp., while four (7%) of the 54 examined by PCR were positive. From the eight positive animals on culture, five were from urban area and three from rural area. On PCR, only one positive animal was from urban area and four were from rural area. Overall, by either test, one of the 54 animals was positive. All samples were collected in free - living animals with no apparent clinical signs of salmonellosis, indicating the potential of capybara as reservoir on this ecosystem.

https://doi.org/10.1590/1678-5150-pvb-5761 1320 downloads

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