ABSTRACT Lippia origanoides is a honey shrub which has showed hypotensive potential assessed by in vivo studies. The aim of this work is the development of a pharmaceutical formulation composed by an optimized extract obtained from aerial parts of L. origanoides. The quantification of the naringenin marker in the dry extract and tablets developed was performed, as well as the assessment of the oral acute toxicity in rats. The hydroalcoholic extract of L. origanoides was spray-dried with the addition of colloidal silicon dioxide (Lo-HAE/CSD), and then applied in the preparation of eight different lots of tablets. The influence of the diluent (cellulose or babassu mesocarp), the presence of binder, and the percentage of lubricant, as well as organoleptic and physicochemical characteristics were screened. For the quantification of the marker content both in Lo-HAE/CSD and in the tablets, an analytical curve of the naringenin standard was fitted, and the samples were then analyzed in UFLC. The toxicological assessment was performed in female Wistar rats according to the Acute Toxic Class Method from OECD. The developed tablets produced meet acceptable macroscopic characteristics, and the presence of babassu as diluent provided improved physicochemical properties. The best content of Lo-HAE/CSD in the tablet (100.27%) was identified for the lot containing babassu, composed by 1.0% magnesium stearate, without PVP binder in its formulation. Moreover, Lo-HAE/CSD showed no signs of toxicity. Therefore, the babassu mesocarp powder is a promising pharmaceutical excipient for the development of herbal tablets containing the Lippia origanoides extract.

A cognição humana tem sido foco de diversas investigações no campo da psicologia do desenvolvimento, buscando-se construir um referencial teórico-empírico para orientar estudos e intervenções nesta direção. O debate tem se situado em torno de grandes paradigmas - piagetiano, neopiagetiano, processamento informacional, contextual e biológico-maturacional/neurociência cognitiva, sendo considerados, por vezes, enquanto referencial absoluto de verdade, e percebidos como excludentes entre si. O objetivo deste trabalho consiste em realizar uma breve retrospectiva dessas vertentes teóricas, buscando identificar pontos de interlocução entre elas, na tentativa de apreendê-las enquanto um corpo de conhecimentos que se complementam e integram vários olhares sobre a mente humana.

The human cognition has been focused by diverse inquiries in the field of the development psychology, searching to construct a theoretician-empiricist referential to guide studies and interventions in this direction. The debate has been situated around great paradigms - Piagetian, Neopiagetian, informational and contextual processing and cognitive biological-maturational/neuroscience, being considered, sometimes, as an absolute referential of truth, and perceived as excludents among them. The objective of this work consists in carrying through a brief retrospect of these theoretical sources, searching to identify interlocution points between them, in the attempt to apprehend them while a body of knowledge that can complement and integrate some views about human mind.