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Retrospective study of radiographic changes in athletic bulls with orthopedic disorders
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Cholfe, Bruno F.

; Silva, José R.B.

; Filho, Alfredo M.

; Souza, Caroline G.

; Filho, Antônio M.T.

; Perri, Silvia H.V.

; Vulcano, Luiz C.

; Rodrigues, Celso A.

Pesquisa Veterinária Brasileira

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nov 2019, Volume 39 N. 11 Pages 858 - 862

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: O objetivo desse trabalho foi demostrar quais lesões acometem touros atletas, correlacionando as desordens com peso, idade, membro e região afetada. O presente estudo foi realizado utilizando radiografias de touros atletas de rodeio, após levantamento dos prontuários clínicos e cirúrgicos do serviço de grandes animais de um hospital veterinário. Foram avaliadas radiografias de 136 touros que haviam sido atendidos em tal hospital, com idade variando de quatro a 13 anos, com média de peso de 800kg e realizavam participação em rodeios. Para avaliar a associação entre as variáveis estudadas foi utilizado o teste exato de Fischer e o Qui-quadrado. Observou-se que 71,6% dos touros estudados que claudicavam, apresentavam lesões radiográficas, predominantemente em animais mais experientes. A entesiopatia em todos os animais, artrite séptica nos touros iniciantes, fraturas e doença articular degenerativa nos touros mais experientes, foram as alterações radiográficas mais frequentes. As regiões com maior ocorrência de lesões radiográficas foram os dígitos. Os fatores de risco para ocorrência de doenças no sistema locomotor de touros atletas são diversos, similares aos que ocorrem nos equinos atletas.

ABSTRACT: The objectives of this study were to demonstrate the lesions that affect athlete bulls and to correlate the disorders with weight, age, affected limb and region of the limb. The present study was accomplished using radiographic images of athletic rodeo bulls collected from the medical and surgical records of the large animal service at the veterinary hospital. Radiographic images were evaluated for 136 bulls that were taken care of at the Veterinary Hospital, ranging in age from 4 to 13 years, with an average weight of 800kg and proven prior physical activity through participation in rodeos. The chi-square or Fisher’s exact test was used to assess the association between the studied variables. It was observed that 71.6% of the bulls studied and suffering from lameness had radiographic lesions, predominantly in experienced animals. Enthesopathy in starter and experienced bulls, septic arthritis in starter bulls, and fractures and degenerative joint disease in experienced bulls were the most frequent radiographic lesions diagnosed. The region of limb where the majority of radiographic changes occurred was the digits. Risk factors and occurrence of diseases of the locomotor system in athletic bulls are similar to those in sport equines.

https://doi.org/10.1590/1678-5150-pvb-6412 837 downloads

COMPOSIÇÃO QUÍMICA, ATIVIDADE ANTIRADICALAR E ANTIMICROBIANA DO PÓLEN APÍCOLA DE FABACEAE
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Caldas, Francisco R. L.

; Augusto Filho, Francisco

; Facundo, Heberty T.

; Alves, Rodolfo F.

; Santos, Francisco de A. R. dos

; Silva, Girliane R. da

; Camara, Celso A.

; Silva, Tania M. S.

Química Nova

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jan 2019, Volume 42 N. 1 Pages 49 - 56

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

The aim of this investigation was to analyze two samples of pollen collected by Apis mellifera bees in view of their chemical composition, antiradicalar and antimicrobial activities. Palynological analysis showed that the predominant pollen was Fabaceae species (42.3%, sample I and 50.6%, sample II). The characterization by ultra-performance liquid chromatography coupled with a diode array detector and quadrupole time of flight mass spectrometry (UPLC-DAD-QTOF-MS/MS) resulted in the identification of three derivatives of putrescine (di-4-coumaroylputrescine, coumaroyl-feruloyl-putrescine and di-feruloyl-putrescine), two spermidine derivatives (coumaroyl-di-cafeoyl-spermidine and tri-coumaroyl-spermidine and four biflavonoids (2,3-di-hydrohydroxy-amentoflavone, 2,3-dihydro-amentoflavone, amentoflavone and 2,3-dihydro-biapigenin). The two samples showed antiradical and antimicrobial activities, probably due to the presence of these compounds.

https://doi.org/10.21577/0100-4042.20170305 1439 downloads

Serum immunoglobulin from Nellore cattle produced by in vitro fertilization and treated for umbilical diseases
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Rodrigues, Celso Antonio

; Santos, Paulo Sergio P.

; Feitosa, Francisco Leydson F.

; Perri, Sílvia Helena V.

; Lisboa, Júlio Augusto N.

; Teodoro, Piero Henrique M.

; Araújo, Marcelo Augusto de

; Viana Filho, Mário Nelson

Pesquisa Veterinária Brasileira

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feb 2018, Volume 38 N. 2 Pages 256 - 261

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: Os objetivos desse estudo foram mensurar as concentrações séricas das imunoglobulinas de bovinos Nelore, produzidos por fertilização in vitro (FIV), acometidos por onfalopatias e avaliar a excisão cirúrgica como método de tratamento. Utilizou-se 16 animais, com idade variando de 1 a 15 meses, machos e fêmeas, acometidos por afecções umbilicais. Amostras de sangue foram colhidas para realização de hemogramas e avaliação das imunoglobulinas, por meio de eletroforese e turbidimetria com sulfato de zinco. Foram observados quatro casos de hérnias umbilicais, dois de hérnia umbilical associadas à persistência de úraco, dois casos de hérnia umbilical com persistência de úraco e onfaloarterite, três de hérnia umbilical com divertículo de úraco, três casos de persistência de úraco, um de divertículo de úraco e um de onfalite. O hemograma revelou diferença significativa para os valores de Volume Globular e Leucócitos, nos momentos pré e pós-tratamento cirúrgico dos animais. A eletroforese evidenciou valores de imunoglobulina abaixo da normalidade na maioria dos animais, enquanto que a turbidimetria apresentou níveis normais na maioria dos bovinos, quando comparados com valores de referência. A maioria dos bovinos estudados, acometidos de onfalopatias e concebidos por FIV, apresentaram hipoglobulinemia. Os resultados obtidos não permitem afirmar que existe relação entre as onfalopatias, falha de transferência de imunidade passiva e FIV.

ABSTRACT: The aim of this study was to measure serum immunoglobulin concentrations of Nellore cattle produced by in vitro fertilization (IVF) with umbilical diseases and to evaluate surgical excision as a method of treatment. Sixteen cattle with ages ranging from 1 to 15 months, males and females, affected by umbilical diseases were enrolled in the study. Blood samples were collected for cell counts and the determination of immunoglobulin concentrations by electrophoresis and zinc sulphate turbidimetry (ZST). Four calves were presented with umbilical herniation, two with an umbilical herniation associated with a persistent urachus, two with an umbilical herniation with a persistent urachus and omphaloarteritis, three with an umbilical herniation and an urachal diverticulum, three with a persistent urachus, one with an urachal diverticulum, and one with omphalitis. The blood cell counts pre- and post-surgical revealed differences in cell volume and the number of leukocytes. The immunoglobulin values measured by electrophoresis values were below normal in most animals, whereas the ZST showed normal levels in most of them. Most of the calves affected by umbilical diseases and produced by IVF presented hypoglobulinaemia. Correlations between umbilical diseases, failure of passive transfer of immunity and IVF could not be demonstrated.

https://doi.org/10.1590/1678-5150-pvb-4899 884 downloads

Anti-Trypanosoma Activity and Synergistic Effects of Natural and Semi-Synthetic Triterpenes and Predominant Cell Death through Autophagy in Amastigote Forms
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Bossolani, Gleison D. P.

; Ueda-Nakamura, Tânia

; Silva, Sueli O.

; Dias Filho, Benedito P.

; Costa, Tulio O. G.

; Quintanilla, Raúl H. R.

; Martinez, Sabrina T.

; Veiga-Junior, Valdir F.

; Pinto, Angelo C.

; Nakamura, Celso V.

Journal of the Brazilian Chemical Society

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dec 2017, Volume 28 N. 12 Pages 2473 - 2489

Abstract: En | Text: En | PDF: En

Chagas' disease is a parasitic disease with unsatisfactory treatment, mainly in chronic stage. This study aimed to evaluate the trypanocidal activity and action mechanisms of α/β-amyrin and its semi-synthetic derivatives, together with four isolated natural triterpenes, tested against trypomastigote and amastigote forms. The structure-activity relationship was suggested and cytotoxicity was measured. In general, greater polar compounds may have improved the selectivity to the protozoan. Action mechanisms were only performed for the amastigotes of Trypanosoma cruzi by evaluating the ultrastructural alterations, membrane permeability, mitochondrial membrane potential and cell volume, since the majority of compounds displayed promising antiamastigote activities. Triterpenes promoted changes on mitochondrial membrane potential and ultrastructural features that suggest autophagy processes. Both combinations between α/β-amyrin and 3-O-acetyl-11-oxo-α/β-amyrin and 3-O-acetyl-α/β-amyrin with benznidazole displayed synergistic effects against amastigotes and antagonistic effects on LLCMK2 cells. The antiamastigote activities, chemical derivatization, drug combinations and action mechanisms revealed to be crucial approaches toward this chronic disease.

https://doi.org/10.21577/0103-5053.20170103 691 downloads

Memantine prevents cardiomyocytes nuclear size reduction in the left ventricle of rats exposed to cold stress
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Meneghini, Adriano

; Ferreira, Celso

; Abreu, Luiz Carlos de

; Valenti, Vitor E.

; Ferreira, Marcelo

; F. Filho, Celso

; Murad, Neif

Clinics

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2009, Volume 64 N. 9 Pages 921 - 926

Abstract: En | Text: En | PDF: En

OBJECTIVES: Memantine is an N-methyl-d-aspartate (NMDA) glutamate receptor antagonist used to treat Alzheimer's disease. Previous studies have suggested that receptor blockers act as neuroprotective agents; however, no study has specifically investigated the impact that these drugs have on the heart. We sought to evaluate the effects of memantine on nuclear size reduction in cardiac cells exposed to cold stress. METHOD: We used male EPM-Wistar rats (n=40) divided into 4 groups: 1) Matched control (CON); 2) Memantine-treated rats (MEM); 3) Rats undergoing induced hypothermia (IH) and 4) Rats undergoing induced hypothermia that were also treated with memantine (IHM). Animals in the MEM and IHM groups were treated by oral gavage administration of 20 mg/kg/day memantine over an eight-day period. Animals in the IH and IHM groups were submitted to 4 hours of hypothermia in a controlled environment with a temperature of - 8ºC on the last day of the study. RESULTS: The MEM group had the largest cardiomyocyte nuclear size (151 ± 3.5 μm³ vs. CON: 142 ± 2.3 μm³; p<0.05), while the IH group had the smallest mean value of nuclear size. The nuclear size of the IHM group was preserved (125 ± 2.9 μm³) compared to the IH group (108 ± 1.7 μm³; p<0.05). CONCLUSION: Memantine prevented the nuclear size reduction of cardiomyocytes in rats exposed to cold stress.

2027 downloads Cited 5 times in SciELO

Antimicrobial activity of Brazilian copaiba oils obtained from different species of the Copaifera genus
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Santos, Adriana Oliveira dos

; Ueda-Nakamura, Tânia

; Dias Filho, Benedito Prado

; Veiga Junior, Valdir F

; Pinto, Angelo C

; Nakamura, Celso Vataru

Memórias do Instituto Oswaldo Cruz

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may 2008, Volume 103 N. 3 Pages 277 - 281

Abstract: En | Text: En | PDF: En

The antimicrobial activity of copaiba oils was tested against Gram-positive and Gram-negative bacteria, yeast, and dermatophytes. Oils obtained from Copaifera martii, Copaifera officinalis, and Copaifera reticulata (collected in the state of Acre) were active against Gram-positive species (Staphylococcus aureus, methicillin-resistant S. aureus, Staphylococcus epidermidis, Bacillus subtilis, and Enterococcus faecalis) with minimum inhibitory concentrations ranging from 31.3-62.5 µg/ml. The oils showed bactericidal activity, decreasing the viability of these Gram-positive bacteria within 3 h. Moderate activity was observed against dermatophyte fungi (Trichophyton rubrum and Microsporum canis). The oils showed no activity against Gram-negative bacteria and yeast. Scannning electron microscopy of S. aureus treated with resin oil from C. martii revealed lysis of the bacteria, causing cellular agglomerates. Transmission electron microscopy revealed disruption and damage to the cell wall, resulting in the release of cytoplasmic compounds, alterations in morphology, and a decrease in cell volume, indicating that copaiba oil may affect the cell wall.

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Atributos físicos e requerimento de potência de uma semeadora-adubadora em um Latossolo sob estados de compactação
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Bonini, Andreia K.

; Gabriel Filho, Antonio

; Secco, Deonir

; Souza, Renan F. de

; Tavares, Celso

Engenharia Agrícola

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mar 2008, Volume 28 N. 1 Pages 136 - 144

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Este experimento foi desenvolvido em um Latossolo, no Núcleo Experimental de Engenharia Agrícola, localizado em Cascavel - PR, com o objetivo de avaliar os atributos físicos e o esforço tratório de semeadora-adubadora em quatro estados de compactação, e sua influência na população inicial das culturas de soja e milho. O delineamento consistiu em esquema "Split Block", com dois fatores, sendo duas culturas (soja e milho) no primeiro fator e quatro estados de compactação no segundo fator, totalizando oito tratamentos. Os tratamentos foram: T0 - sem compactação adicional; T1 - com uma passada; T3 - com três passadas, e T5 - com cinco passadas de rolo compactador. Avaliaram-se a profundidade do sulco, a velocidade média de deslocamento, a força e a potência requerida na barra de tração na operação de semeadura, a densidade e a resistência do solo à penetração e, ainda, a população inicial das culturas. Com os resultados observados, pode-se concluir que a pressão aplicada pelo disco duplo defasado não foi suficiente para manter a mesma profundidade de sulco no maior estado de compactação. A resistência à penetração do solo de 2,50 e 3,00 MPa e a densidade do solo máxima de 1,39 Mg m-3 não interferiram na população inicial de plantas de soja, no entanto, para o milho, ocorreu redução nos tratamentos. À medida que ocorreu variação na profundidade de sulcamento e na velocidade de deslocamento, aumentou a força de tração por linha para as duas culturas estudadas.

This experiment was conducted in an Oxisol, in the Experimental Center of Agricultural Engineering, located in Cascavel (PR), Brazil, with the objective of evaluates the physicals attributes and the tractor effort of a planter in four levels of compactation and the influence in the initial population in the cultures of soybean and corn. The experimental outliner scheme was "Split Block", tested with two factors, being two cultures (soy and corn) the first factor and the four levels of compactation the second one, totalizing eight treatments. The four levels of compaction were determined as: T0 - without compaction; T1 - with one pass of the soil compact roll; T3 - with tree, and T5 - with five passes. The parameters evaluated were: the depth of the furrow, average speed, traction force and power force, soil bulk density, soil penetration resistance and the stand of the soybean and corn cultures. The results showed that the applied pressure by the double unbalanced record was not sufficient to maintain the furrow depth in major compactation level.The soil penetration resistance 2.50 and 3.00 MPa and the maximum bulk density 1.39 Mg m-3 did not influence the initial population of the soybean culture, however with the corn culture occurred a reduction in the treatments. When the variation in the depth and the speed of the movement occurred, the strength of traction per line for both cultures studied increased.

1480 downloads

I Diretrizes do Grupo de Estudos em Cardiogeriatria da Sociedade Brasileira de Cardiologia
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Franken, Roberto Alexandre

; Taddei, Cláudia F. Gravina

; Maia, Ivan Gonçalves

; Batlouni, Michel

; Sousa, J.Eduardo Moraes Rego

; Wajngarten, Maurício

; Feitosa, Gilson Soares

; Lorga, Adalberto

; Paola, Angelo de

; Scatolini Neto, Argemiro

; Halperin, Cidio

; Moreira, Dalmo

; Hachul, Denise

; Savioli, Felicio

; Atiê, Jacob

; Gagliardi, Rubens

; Avezum, Alvaro

; Bocchi, Edimar A.

; Dohmann, Hans J. F.

; Pereira Filho, Ilnei

; Saraiva, J. Francisco Kerr

; Bodanese, Luis C.

; Leal, Marcelo Garcia

; Afiune Neto, Abrahão

; Libberman, Alberto

; Sousa, Amanda G. M. R.

; Sousa, Antonio Carlos S.

; Caramelli, Bruno

; Geraldez, Roberto R.C.

; Brandão, Airton P.

; Markman Filho, Brivaldo

; Amodeo, Celso

; Ferreira, Celso

; Souza Filho, João

; Siqueira, J Eduardo

; Gonçalves Júnior, Iran

; Makdisse, Marcia P.

; Luna, Rafael L

; Rosa, Ronaldo F.

; Luis, Carlos de Camargo

; Freitas, Elizabete Viana

; Tarasoutchi, Flávio

; Pierri, Humberto

; Santos, Silvio Carlos de M.

; Meneghello, Zilda M.

; Magalhães, Carlos C.

; Nasri, Fabio

; Gus, Iseu

; Borges, Jairo

; Serro Azul, João Batista

; Aldrighi, José M.

; Ghorayeb, Nabil

; Grespan, Stela Maris

Arquivos Brasileiros de Cardiologia

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2002, Volume 79 Suppl. 1 Pages 1 - 46

Abstract: Pt | Text: Pt | PDF: Pt

50012 downloads Cited 1 time in SciELO

Tratamentos focais e totais com inseticidas de ação residual para o controle de Triatoma brasiliensis e Triatoma pseudomaculata no Nordeste brasileiro
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Oliveira Filho, Alfredo M.

; Melo, Marli T. V.

; Santos, Celso E.

; Faria Filho, Oswaldo F.

; Carneiro, Francisco C. F.

; Oliveira-Lima, José Wellington

; Vieira, João Batista Furtado

; Gadelha, Francisco Vieira

; Ishihata, Jorge

Cadernos de Saúde Pública

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2000, Volume 16 Suppl. 2 Pages S105 - S111

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Para controle eficiente dos triatomíneos Triatoma brasiliensis e Triatoma pseudomaculata, foi feito um ensaio de campo em Boa Viagem, Ceará, de modo a comparar a borrifação convencional versus tratamento focal com deltametrina 5% SC, dose 25 mg i.a./m² e o organofosforado malation lenta liberação 8.3% SR, dose 2g i.a./m². O ensaio incluiu aleatoriamente 1.541 casas, separadas em quatro grupos. Em dois deles foi aplicada borrifação focal tratamento PT com deltametrina dentro das casas e no peridomicílio e PL que recebeu malation lenta liberação nas mesmas circunstâncias. Os outros dois tiveram tratamento convencional, isto é, aplicação total PT com deltametrina no intra e peridomicílio e PL, tratado com deltametrina dentro das casas e malation lenta liberação no peridomicílio. As avaliações entomológicas aos 6 e 12 meses pós-tratamentos mostraram melhor resultado para o tratamento misto, grupo PL, provavelmente em decorrência da boa performance do piretróide dentro das casas e da formulação de lenta liberação nas condições hostis do peridomicílio. Os abrigos dos animais domésticos sofreram modificações ao longo do ano, colaborando com a redução da performance dos inseticidas no peridomicílio.

To efficiently control the triatomines Triatoma brasiliensis and Triatoma pseudomaculata, a field trial was performed to compare conventional versus focal spraying of deltamethrin 5% SC at 25 mg a.i./m² and the slow-release organophosphate malathion 8.3% SR at 2g a.i./m². The assay took place in the county of Boa Viagem, Ceará State, with 1541 households, randomly separated into 4 groups. Two of them received focal spraying: PT, treated with deltamethrin indoors and in the peridomicile, and PL, which received slow-release malathion in the same circumstances. The other groups received conventional, i.e., total application: PT with deltamethrin in the intra- and peridomicile, and PL, which was treated with deltamethrin indoors and slow-release malathion in the peridomicile. Entomological surveys at 6 and 12 months post-treatment showed better results for mixed treatment, the PL group, probably due to good indoor performance for the pyrethroid and better performance of the slow-release formulation under the hostile peridomiciliary conditions. Domestic animal shelters underwent numerous modifications over the course of the year, fostering reduced insecticide performance in the peridomicile.

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Tratamentos focais e totais com inseticidas de ação residual para o controle de Triatoma brasiliensis e Triatoma pseudomaculata no Nordeste brasileiro
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Oliveira Filho, Alfredo M.

; Melo, Marli T. V.

; Santos, Celso E.

; Faria Filho, Oswaldo F.

; Carneiro, Francisco C. F.

; Oliveira-Lima, José Wellington

; Vieira, João Batista Furtado

; Gadelha, Francisco Vieira

; Ishihata, Jorge

Cadernos de Saúde Pública

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2000, Volume 16 Suppl. 2 Pages S105 - S111

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

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