ABSTRACT Objective: To assess the association between dental caries experience, severe dental caries experience and socioeconomic determinants on oral health-related quality of life among children and their families. Material and Methods: This is a cross-sectional study whose sample was composed of children aged 4-12 years, who sought dental care in a dentistry school clinic, and their parents/caregivers. Dental caries experience and severe dental caries experience were assessed according to the DMF-T/dmf-t indexes. Parents/caregivers answered the Parental-Caregiver Perceptions Questionnaire (P-CPQ), the Family Impact Scale (FIS) and a questionnaire on socioeconomic and demographic conditions. Data analysis included the chi-square test and Poisson regression (PR). Results: The sample was composed of 105 children and their parents/caregivers. Severe dental caries experience in children was determinant for negative perception of children's OHRQoL by parents/caregivers (PR = 1.22; CI = 1.05-1.41). Negative impact on OHRQoL perceived by family members was determined by severe dental caries experience in children (PR = 1.22; CI = 1.05-1.42) and family income <5 minimum wage (PR = 1.32; CI = 1.08-1.61). Conclusion: Severe dental caries experience was associated with a negative impact on OHRQoL perceived by children and their families. Low family income was associated with a negative impact on the OHRQoL perceived by children and their families.

Resumo A malária é um problema de saúde pública, sendo o Brasil, na América, o país que mais contribui com o número de casos. A Amazônia Legal concentra a maioria dos casos, cerca de 99,5%. O objetivo deste artigo é comparar as tendências da taxa de desflorestamento e o índice parasitário por malária na região da Amazônia Legal entre 1996 e 2012. Foram estimados a taxa bruta anual de desflorestamento e o Índice Parasitário Anual de Malária entre 1996 e 2012, para a Amazômia Legal e seus estados. Obtiveram-se a série histórica dos dois indicadores e as estatísticas descritivas por ano e por estado. A taxa de desflorestamento apresenta grande variabilidade entre os estados, ano a ano, e situação semelhante é observada para o IPA de malária no período. Há variação importante quando são observados os estados dentro do mesmo período. As séries históricas da taxa bruta de desflorestamento e do IPA de malária apresentam tendências semelhantes, com um lag de 1-2 anos entre elas, sugerindo que as oscilações nos números de desflorestamento impactam os números de malária em período imediatamente posterior. O mapeamento das áreas desflorestadas e a análise de séries temporais, portanto, são úteis na análise da malária.

Abstract Malaria is a major public health problem, and Brazil is the largest contributor in America to the number of cases. In the country, the Amazon concentrates around 99.5% of the cases. This article aims to compare trends in deforestation rate and the parasite index of malaria in the Amazon region between 1996 and 2012. The annual crude rate of deforestation and the Annual Parasite Index (API) of malaria between 1996 and 2012 were estimated. The rate of deforestation has great variability among the states every year, and a similar situation is observed for malaria API over the studied period. There are important variations across the states within this period. The historical series of crude deforestation rate and malaria API have markedly similar trends; with a 1-2 years lag between them, suggesting that the occurrence of fluctuations in deforestation numbers impacts malaria numbers in a period immediately following. The mapping of deforested areas and the analysis of temporal series are therefore useful in the analysis of malaria.

In this paper, we showed for the first time that the conserved domains within Schistosoma mansoni ATP diphosphohydrolase isoforms, shared with potato apyrase, possess epitopes for the IgG1 and IgG4 subtypes, as 24 (80%) of the 30 schistosomiasis patients were seropositive for this vegetable protein. The analyses for each patient cured (n = 14) after treatment (AT) with praziquantel revealed variable IgG1 and IgG4 reactivity against potato apyrase. Different antigenic epitopes shared between the vegetable and parasite proteins could be involved in susceptibility or resistance to S. mansoni AT with praziquantel and these possibilities should be explored.