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Objective: to evaluate the association between risk classification and door-to-antibiotic time in patients with suspected sepsis. Method: retrospective cohort study, with a sample of 232 patients with suspected sepsis treated at the emergency department. They were divided into 2 groups: with and without risk classification. Once the door-to-antibiotic time was identified, one-way analysis of variance was performed with Bonferroni post hoc test or independent Student’s t-test for continuous quantitative variables; Pearson correlation tests, point-biserial correlation or biserial correlation for association analyses; and bootstrap procedure when there was no normal distribution of variables. For data analysis, the Statistical Package for the Social Sciences software was used. Results: the door-to-antibiotic time did not differ between the group that received risk classification compared to the one that was not classified. Door-to-antibiotic time was significantly shorter in the group that received a high priority risk classification. Conclusion: there was no association between door-to-antibiotic time and whether or not the risk classification was performed, nor with hospitalization in infirmaries and intensive care units, or with the length of hospital stay. It was observed that the higher the priority, the shorter the door-to-antibiotic time.

Objetivo: evaluar la asociación entre la clasificación de riesgo y el tiempo puerta-antibiótico en pacientes con sospecha de sepsis. Método: estudio de cohorte retrospectivo, con una muestra de 232 pacientes con sospecha de sepsis atendidos en el departamento de emergencias. Se dividieron en 2 grupos: con y sin clasificación de riesgo. Una vez identificado el tiempo puerta-antibiótico, se realizó un análisis de varianza de un factor con la prueba post hoc de Bonferroni o la prueba t de Student independiente para variables cuantitativas continuas; pruebas de correlación de Pearson, correlación biserial puntual o correlación biserial para análisis de asociación; y procedimiento de bootstrap cuando no había distribución normal de variables. Para el análisis de los datos se utilizó el software Statistical Package for the Social Sciences. Resultados: el tiempo puerta-antibiótico no difirió entre el grupo que recibió clasificación de riesgo en comparación con el que no fue clasificado. El tiempo puerta-antibiótico fue significativamente más corto en el grupo que recibió una clasificación de riesgo de alta prioridad. Conclusión: no hubo asociación entre el tiempo puerta-antibiótico y si se realizó o no la clasificación de riesgo, ni con la hospitalización en enfermería y en unidad de cuidados intensivos, ni con la duración de la estancia hospitalaria. Se observó que cuanto mayor era la prioridad, más corto era el tiempo puerta-antibiótico.

Objetivo: avaliar a associação entre a realização de classificação de risco e o tempo porta-antibiótico no paciente com suspeita de sepse. Método: estudo de coorte retrospectivo, com amostra de 232 pacientes com suspeita de sepse atendidos no pronto atendimento. Foram distribuídos em 2 grupos: com e sem classificação de risco. Identificado o tempo porta-antibiótico, realizou-se análise de variância de um fator com post hoc de Bonferroni ou teste T-Student independente para variáveis quantitativas contínuas; testes de correlação de Pearson, correlação bisserial por pontos ou correlação bisserial para análises de associação; e procedimento de bootstrap quando não havia distribuição normal de variáveis. Para a análise dos dados foi utilizado o software Statistical Package for the Social Sciences. Resultados: o tempo porta-antibiótico não diferiu entre o grupo que recebeu classificação de risco comparado ao que não foi classificado. O tempo porta-antibiótico foi significativamente menor no grupo que recebeu classificação de risco de alta prioridade. Conclusão: não houve associação entre o tempo porta-antibiótico e a realização ou não da classificação de risco, tampouco com internação em enfermaria e em unidade de terapia intensiva, ou com o tempo de internação hospitalar. Observou-se que quanto maior a prioridade, menor o tempo porta-antibiótico.

https://doi.org/10.1590/1518-8345.6635.4064

Dessensibilização à carboplatina e metotrexato em idade pediátrica: Revisão de um serviço
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Vasconcelos, Maria João

; Carneiro-Leão, Leonor

; Fernandes, Ana Paula

; Almeida, Marta

; Gil-da-Costa, Maria João

; Cernadas, Josefina

Revista Portuguesa de Imunoalergologia

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sep 2023, Volume 31 N. 3 Pages 205 - 215

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT Background: Hypersensitivity reactions during chemotherapy have been increasingly documented in children. Drug desensitization is an unknown procedure for most oncologists, despite allowing patients to be treated with first-line agents, affecting the final prognosis. Currently, there are no guidelines for drug desensitization in pediatric age, and the general principles adopted for adults have been applied to children. Objective: To describe the experience of an Immunoallergology department of a central hospital in the desensitization to carboplatin and methotrexate in pediatric age. Results: Desensitizations were performed on carboplatin in 17 patients, in a total of 112 procedures, and on methotrexate in 4 children, with a success rate of 88% for carboplatin and 100% for methotrexate. Conclusion: As far as the authors are aware, this is the largest European series of desensitizations to chemotherapy in pediatric age, including procedures in infants and in non-immediate reactions.

RESUMO Fundamentos: As reações de hipersensibilidade durante a quimioterapia em crianças têm sido documentadas de forma crescente. A dessensibilização a fármacos é um procedimento desconhecido por grande parte dos oncologistas, apesar de permitir que os doentes sejam tratados com agentes de primeira linha, afetando o prognóstico final. Atualmente, ainda não existem normas de orientação de dessensibilização a fármacos em idade pediátrica e os princípios gerais adotados para os adultos têm sido aplicados em crianças. Objetivo: Descrever a experiência de um serviço de imunoalergologia de um hospital central na dessensibilização à carboplatina e ao metotrexato em idade pediátrica. Resultados: Foram realizadas dessensibilizações à carboplatina em 17 crianças, num total de 112 procedimentos, e ao metotrexato em 4 crianças, com uma taxa de sucesso de 88% para a carboplatina e de 100% para o metotrexato. Conclusão: Tanto quanto é do conhecimento das autoras, esta é a maior série europeia de dessensibilizações a quimioterápicos em idade pediátrica, tendo sido realizadas, inclusivamente, procedimentos num lactente e numa reação não imediata.

https://doi.org/10.32932/rpia.2023.08.116

PCR identification of lactic acid bacteria populations in corn silage inoculated with lyophilised or activated Lactobacillus buchneri
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Santos, Ana Paula Maia dos

; Santos, Edson Mauro

; Silva de Oliveira, Juliana

; Garcia Leal de Araújo, Gherman

; de Moura Zanine, Anderson

; Araújo Pinho, Ricardo Martins

; Costa do Nascimento, Thiago Vinicius

; Fernandes Perazzo, Alexandre

; Ferreira, Daniele de Jesus

; da Silva Macedo, Alberto Jefferson

; de Sousa Santos, Francisco Naysson

Revista de la Facultad de Ciencias Agrarias. Universidad Nacional de Cuyo

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jun 2023, Volume 55 N. 1 Pages 115 - 125

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Este estudio tuvo como objetivo evaluar el efecto de la inoculación con L. buchneri liofilizado y/o activado sobre las poblaciones de bacterias de ácido láctico en ensilajes de maíz. Los tratamientos experimentales consistieron en ensilaje de maíz sin aditivo y ensilaje con los inoculantes L. buchneri 1 × 10 5 ufc/g, aplicados según las recomendaciones del fabricante (1 g/tonelada de forraje) en las formas de inoculante liofilizado e inoculante preactivado. Se identificaron aislados purificados de ensilajes de maíz con y sin inocu lación, y el 93% de los aislados correspondieron a bacterias de ácido láctico de la especie L. plantarum. Entre los aislados no se detectaron bacterias de la especie L. buchneri. La aplicación de L. buchneri liofilizado o activado en la masa ensilada promueve un aumento considerable de la población de bacterias de ácido lácticas en los ensilajes de maíz durante todo el período de fermentación.

Abstract This study aimed to evaluate the effect of inoculation with lyophilised and/or activated Lactobacillus buchneri on lactic acid bacteria populations in corn silage. Experimental treatments consisted of corn silage without additives or silage with the inoculants of L. buchneri (1 x 10 5 cfu/g) applied according to the manufacturer’s recommendations (1 g/tonne fodder) in the forms of the lyophilised inoculant and pre-activated inoculant. Purified isolates from corn silage with and without the inoculant were identified, and 93% of the isolates corresponded to the lactic acid bacteria of the species Lactobacillus plantarum. Among the isolates, no bacteria of the species L. buchneri were detected. The application of lyophilised or activated L. buchneri improved the microbiological profile and reduced ethanol production in corn silage, even without being identified among the isolates captured 70 days after ensilage.

PAAI - Interactive online self-learning programme for patients with asthma: Protocol for co-creation and impact
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Jácome, Cristina

; Fonseca, Nancy

; Rodrigues, Tânia

; Fernandes, Silvana

; Costa, Emília Dias da

; Amaral, Rita

; Matos, Paula

; Areia, Margarida

; Dias, Liliana

; Vilaverde, Marisa

; Loureiro, Cláudia Chaves

; Boechat, José Laerte

; Reis, António Baía

; Figueiredo, Daniela

; Neves, Ana Luísa

; Simões, Pedro

; Barata, Luis Taborda

; Fonseca, João Almeida

; Sá-Sousa, Ana

Revista Portuguesa de Imunoalergologia

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jun 2023, Volume 31 N. 2 Pages 151 - 161

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT Patient and Public Involvement (PPI) in research should focus on the engagement of patients/carers in every stage of the research cycle. However, the inconsistent level of education and research experience may compromise this involvement and training and support are recommended. In Portugal, consistent training to empower patients in their health decisions, or to be involved in research is neither available nor adapted for the patients and public. Our main goal is to develop and deliver the first high-quality and comprehensive online educational programme for adult patients with asthma and their carers, based on patients’/carers’ needs and preferences. The project includes four tasks. In Task 1, we will identify and organise the most important topics on asthma and health research, based on the identification of educational needs of adult patients/carers with asthma and the expertise of asthma specialists, using Delphi methodology. In Task 2, we will design and implement a high-quality, free, online self-learning programme based on reliable sources of information and on patients’/carers’ preferences. In Task 3, we will assess its feasibility, satisfaction and impact. Finally, Task 4 will be centred on the management and dissemination. Patients and carers will be actively engaged in all stages of this project as co-researchers, including the writing of this protocol. By the end of this project, we expect to have implemented the first high-quality, free-of-charge, online self-learning programme on asthma and health research, adapted for adult patients with asthma and their carers. It will be available for all patients/carers not only from Portugal but also from all Lusophone countries. This programme will empower patients and carers to increase their knowledge about the disease, develop new skills and have the opportunity to learn about research. Ultimately, it will introduce the knowledge patients/carers need to represent themselves and influence health policies in Portugal successfully.

RESUMO O envolvimento dos doentes e cidadãos na investigação (PPI) deve ocorrer em todas as etapas do ciclo de investigação. No entanto, a inconsistência nos níveis educacionais e na experiência de investigação pode ser um entrave significativo de uma participação ativa. Assim, ações de formação e suporte são recomendadas. Em Portugal, não existe formação específica para capacitar os doentes nas suas decisões de saúde, ou para se envolverem em investigação. O objetivo principal é desenvolver e tornar acessível o primeiro programa educacional online de elevada qualidade para doentes adultos com asma e seus cuidadores, com base nas suas necessidades e preferências. O projeto inclui 4 tarefas. Na tarefa 1 iremos identificar os tópicos mais importantes na área da asma e investigação em saúde, a partir da identificação das necessidades educacionais de doentes/cuidadores e da experiência de especialistas em asma, usando o método Delphi. Na tarefa 2 pretendemos desenhar e implementar um programa de elevada qualidade, gratuito e online, baseado em fontes de informação fiáveis e nas preferências de doentes/cuidadores. Na tarefa 3 vamos disseminar o programa e avaliar a sua exequibilidade, aceitabilidade e impacto. A tarefa 4 irá incidir na gestão e disseminação do projeto. Doentes e cuidadores estarão ativamente envolvidos em todas as tarefas do projeto como coinvestigadores, onde se inclui a escrita deste protocolo. No final deste projeto, esperamos ter implementado o primeiro programa de auto-aprendizagem de elevada qualidade, gratuito e online para a asma e investigação em saúde, adaptado para doentes/cuidadores com asma. Este programa irá capacitar doentes e cuidadores para aumentar o seu conhecimento sobre a doença, para desenvolver novas competências, e será uma oportunidade para aprenderem sobre investigação. Este programa permitirá também a introdução a conhecimentos necessários para doentes e cuidadores se fazerem representar e influenciarem as políticas em saúde em Portugal.

https://doi.org/10.32932/rpia.2023.04.111

Depressive symptoms and receipt of pensions: a cross-sectional analysis of the ELSI-Brazil study
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Freitas, Ana Paula Goulart de

; Sena, Klaide Lopes de

; Rodrigues, Jôsi Fernandes de Castro

Epidemiologia e Serviços de Saúde

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2023, Volume 32 N. 3 elocation e2023294

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivo Investigar a associação entre recebimento de aposentadorias ou pensões e sintomas depressivos na população brasileira com 50 anos ou mais. Método Estudo transversal com participantes da linha de base (2015-2016) do Estudo Longitudinal da Saúde dos Idosos Brasileiros. Sintomas depressivos foram aferidos pela escala The eight-item Center for Epidemiologic Studies Depression. Razões de prevalência (RP) foram obtidas pela regressão de Poisson. Resultados Dos 8.469 participantes, 33,9% (IC95% 32,8;34,9) relataram sintomas depressivos e 52,8% (IC95% 51,8;53,9) recebiam aposentadoria ou pensão. A prevalência de sintomas depressivos foi menor entre os participantes que recebiam aposentadoria ou pensão (RP = 0,79; IC95% 0,73;0,86). A associação permaneceu significativa após ajustes por indicadores sociodemográficos e de saúde (RP = 0,84; IC95% 0,76;0,92). Conclusão Participantes que recebiam aposentadoria ou pensão são menos propensos a relatarem sintomas depressivos.

ABSTRACT Objective To investigate association between depressive symptoms and receipt of retirement pensions or other pensions in the Brazilian population aged 50 years or older. Method This was a cross-sectional study with participants from the baseline (2015-2016) of the Longitudinal Study of the Health of Elderly Brazilians. Depressive symptoms were measured by the eight-item Center for Epidemiologic Studies Depression Scale. Prevalence ratios (PR) were obtained by Poisson regression. Results Among the total 8,469 participants, 33.9% (95%CI 32.8;34.9) reported depressive symptoms and 52.8% (95%CI 51.8;53.9) of the participants received a retirement or other pension. Prevalence of depressive symptoms was lower among participants receiving a retirement or other pension (PR = 0.79; 95%CI 0.73;0.86). Association remained significant after adjustments for sociodemographic and health indicators (PR = 0.84; 95%CI 0.76;0.92). Conclusion Participants who receive retirement or other pensions are less likely to report depressive symptoms.

RESUMEN Objetivo Investigar la asociación entre los síntomas depresivos y la percepción de jubilaciones o pensiones en la población brasileña de 50 años o más. Método Estudio transversal con participantes del Estudio Longitudinal de la Salud del Anciano Brasileño (2015-2016). Los síntomas depresivos se midieron mediante la escala The eight-item Center for Epidemiologic Studies Depression. Las razones de prevalencia (RP) se obtuvieron por regresión de Poisson. Resultados La prevalencia de síntomas depresivos fue del 33,9% (IC95% 32,8;34,9) y 52,8% (IC95% 51,8;53,9) de los participantes recibían jubilación o pensión. La prevalencia de síntomas depresivos fue menor entre los participantes que recibían jubilación o pensión (PR = 0,79; IC95% 0,73;0,86). La asociación siguió siendo significativa tras ajustarse por indicadores sociodemográficos y de salud (PR = 0,84; IC95% 0,76;0,92). Conclusión Los participantes que reciben una jubilación o pensión tienen menos probabilidades de manifestar síntomas depresivos.

https://doi.org/10.1590/s2237-96222023000300017.en

ELMO CPAP: an innovative type of ventilatory support for COVID-19-related acute respiratory distress syndrome
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Beliero, Andréa Mazza

; Lázaro, Ana Paula Pires

; Zaranza, Marza de Sousa

; Lima, Giovanna Mazza Cruz

; Guimarães, Álvaro Rolim

; Aragão, Nilcyeli Linhares

; Meneses, Gdayllon Cavalcante

; Holanda, Marcelo Alcantara

; Albuquerque, Polianna Lemos Moura Moreira

; Silva Júnior, Geraldo Bezerra da

; Fernandes, Paula Frassinetti Castelo Branco Camurça

Jornal Brasileiro de Pneumologia

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2023, Volume 49 N. 6 elocation e20230227

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT Objective: To assess whether the use of ELMO, a helmet for noninvasive ventilation created in Brazil, had a positive impact on the prognosis of patients with hypoxemic respiratory failure caused by severe COVID-19. Methods: This is a retrospective study of 50 critically ill COVID-19 patients. Epidemiological, clinical, and laboratory data were collected on ICU admission, as well as before, during, and after ELMO use. Patients were divided into two groups (success and failure) according to the outcome. Results: ELMO use improved oxygenation parameters such as Pao2, Fio2, and the Pao2/Fio2 ratio, and this contributed to a gradual reduction in Fio2, without an increase in CO2, as determined by arterial blood gas analysis. Patients in the success group had significantly longer survival (p < 0.001), as determined by the Kaplan-Meier analysis, less need for intubation (p < 0.001), fewer days of hospitalization, and a lower incidence of acute kidney injury in comparison with those in the failure group. Conclusions: The significant improvement in oxygenation parameters, the longer survival, as reflected by the reduced need for intubation and by the mortality rate, and the absence of acute kidney injury suggest that the ELMO CPAP system is a promising tool for treating ARDS and similar clinical conditions.

RESUMO Objetivo: Avaliar se o uso do ELMO, um capacete para ventilação não invasiva criado no Brasil, teve impacto positivo no prognóstico de pacientes com insuficiência respiratória hipoxêmica por COVID-19 grave. Métodos: Estudo retrospectivo com 50 pacientes críticos com COVID-19. Dados epidemiológicos, clínicos e laboratoriais foram coletados na admissão na UTI e antes, durante e após o uso do ELMO. Os pacientes foram divididos em dois grupos (sucesso e falha) de acordo com o desfecho. Resultados: O uso do ELMO melhorou parâmetros de oxigenação como Pao2, Fio2 e relação Pao2/Fio2, e isso contribuiu para uma redução gradual da Fio2, sem aumento do CO2, conforme determinado pela gasometria arterial. Os pacientes do grupo sucesso apresentaram sobrevida significativamente maior (p < 0,001), conforme determinado pela análise de Kaplan-Meier, menor necessidade de intubação (p < 0,001), menos dias de hospitalização e menor incidência de lesão renal aguda em comparação com os do grupo falha. Conclusões: A significativa melhora nos parâmetros de oxigenação, a maior sobrevida, refletida pela menor necessidade de intubação e pela taxa de mortalidade, e a ausência de lesão renal aguda sugerem que o sistema ELMO CPAP é uma ferramenta promissora para o tratamento da SDRA e de condições clínicas semelhantes.

https://doi.org/10.36416/1806-3756/e20230227

A survey on brazilian dentists’ awareness, perception, and knowledge of bisphosphonates
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Nunes, Raquel Laís Ottoni

; Anjos, Nicole Ribeiro dos

; Lima, Luciano Henrique Ferreira

; Viana, Ana Paula Cota

; Pereira, Larissa de Ávila

; Bruzinga, Fábio Fernandes Borém

; Grossmann, Soraya de Mattos Camargo

Brazilian Journal of Oral Sciences

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2023, Volume 22 elocation e237544

Abstract: En | Text: En | PDF: En

Aim The purpose of the study was to analyze the knowledge of dentists in Belo Horizonte, Brazil, about bisphosphonates and their clinical implications. Methods A cross-sectional questionnaire-based study was conducted with a convenience sample of dentists in Belo Horizonte, in a period of 8 weeks. The questionnaire was self-applied and was structured with 10 items about the dentists’ demographic characteristics, professional profile, and knowledge about bisphosphonates. Associations in the data were analyzed by with the Fischer’s exact test with a significance level of 5%. Results Of the 214 participating dentists, 163 (76.17%) were women, and 51 (23.83%) were men, with age ranged for 21 to 73 years (mean of 30 years) and mean of 6 years of professional activity. Nearly half (106/49.53%) reported having knowledge about bisphosphonates, and undergraduate courses were the primary source of such information (73/34.11%). Osteoporosis was the most identified indication for use (75/35.04%), although no participants correctly identified all indications. Regarding the drugs’ side effects, only three dentists (1.40%) could correctly identify all responses, with bone necrosis being recognized by the majority (88/41.12%). Sodium alendronate (54/25.23%) and sodium ibandronate (15/7.01%) were the most identified examples of bisphosphonates. Last, only nine dentists (4.20%) could identify all examples of the drugs, and their capacity was associated with self-reported knowledge (p<0.05). Conclusions More information about bisphosphonates should be disseminated in Belo Horizonte, ideally via better approaches in local undergraduate and postgraduate courses. Until then, knowledge of the basic aspects of bisphosphonates will remain limited.

https://doi.org/10.20396/bjos.v22i00.8667544

Optimum plot size and number of replications for experiments with the chickpea
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Magalhães, Jailson Ramos

; Azevedo, Alcinei Mistico

; Valadares, Nermy Ribeiro

; Fernandes, Ana Clara Gonçalves

; Alves, Rayane Aguiar

; Freitas, Igor Costa de

; Gomes, Luan Souza de Paula

; Costa, Cândido Alves da

Revista Ciência Agronômica

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2023, Volume 54 elocation e20228506

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT In agricultural experimentation, use of the optimum plot size is an important way of increasing experimental precision; however, studies of this type are scarce for the chickpea, a legume that has been conquering both the market and consumers throughout the world. The aim of this study, therefore, was to determine the optimum plot size for evaluating experiments with the chickpea, in scenarios comprising combinations of the number of treatments, number of replications and levels of precision. Two blank experiments were carried out, comprising eight crop rows, 7 m in length, at a spacing of 50 cm between rows and 10 cm between plants; the six central rows were evaluated, giving a total of 60 plants per row. The index of soil heterogeneity was determined, and the optimum plot size was estimated using the Hatheway method in scenarios formed by a combination of i treatments (i = 4, 8, 12 and 16), r replications (r = 3, 4, 5, 6, 7 and 8) and levels of precision (LSD = 25%, 30% and 40%). The index of soil heterogeneity was greater than 0.7 for each of the variables under evaluation. The Hatheway method makes it possible to estimate different plot sizes based on the conditions and limitations of the experimental area. In experiments with the chickpea including 4 to 16 treatments, 25% LSD and six replications, plots of 25 basic units are sufficient to identify significant differences between the mean values of the treatments with a probability of 5%.

RESUMO Na experimentação agrícola, a utilização do tamanho ótimo de parcela é uma estratégia importante, para aumentar a precisão experimental, e trabalhos desta natureza são escassos para a cultura do grão-de-bico, leguminosa que vem conquistando o mercado e consumidores em todo o mundo. Assim, o objetivo deste trabalho foi determinar o tamanho ótimo de parcela, para avaliar experimentos com a cultura do grão-de-bico, em cenários formados por combinações de números de tratamentos, números de repetições e níveis de precisão. Dois experimentos em branco foram realizados, compostos por oito linhas de cultivo, de 7 m de comprimento, espaçadas em 50 cm entre linhas e 10 cm entre plantas; foram avaliadas as seis linhas centrais, totalizando 60 plantas por linha de cultivo. Foi determinado o índice de heterogeneidade do solo e o tamanho ótimo de parcela foi estimado por meio do método de Hatheway, em cenários formados pelas combinações de i tratamentos (i = 4, 8, 12 e 16), r repetições (r = 3, 4, 5, 6, 7 e 8) e níveis de precisão (DMS = 25%, 30% e 40%). O índice de heterogeneidade do solo foi superior a 0,7 para todas as variáveis avaliadas. O método de Hatheway possibilita estimar diferentes tamanhos de parcelas, de acordo com as condições e limitações da área experimental. Em experimentos com o grão-de-bico, com 4 a 16 tratamentos, DMS de 25% e seis repetições, as parcelas de 25 unidades básicas são suficientes para identificar, com probabilidade de 5%, diferenças significativas entre as médias dos tratamentos.

https://doi.org/10.5935/1806-6690.20230032

10.

Dental and composite resin discoloration induced by different hydraulic calcium silicate-based cements: two-year in vitro assessment
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JESUS, Lucas Santos de

; REIS, Tiago Lopes dos Santos

; MACHADO, Bernardo Guerra Mendonça de Melo

; COSTA, Ana Luísa Monteiro da

; SAVARIS, Julia Menezes

; VOLPATO, Claudia Angela Maziero

; BORTOLUZZI, Eduardo Antunes

; TEIXEIRA, Cleonice da Silveira

; FERNANDES, Paula Cristina dos Santos Vaz

; GARCIA, Lucas da Fonseca Roberti

Journal of Applied Oral Science

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2023, Volume 31 elocation e20220444

Abstract: En | Text: En | PDF: En

Abstract Few long-term studies assess the discoloration induced by hydraulic calcium silicate-based cement on dental structures. In addition, as far as we know, no long-term study has assessed the discoloration induced by these cement on composite resin. Objective This in vitro study aimed to assess, during a period of two years, the discoloration potential of different hydraulic calcium silicate-based cements (hCSCs) on the enamel/dentin structure and composite resin restoration. Methodology A total of 40 enamel/dentin discs were obtained from bovine incisors, and 40 composite resin discs (10 mm in diameter × 2 mm thick) were fabricated. A 0.8 mm-deep cavity was made in the center of each disc and filled with the following hCSCs (n=10): Original MTA (Angelus); MTA Repair HP (Angelus); NeoMTA Plus (Avalon); and Biodentine (Septodont). An initial color measurement was performed (T0 - baseline). After 7, 15, 30, 45, 90, 300 days, and two years, new color measurements were performed to determine the color (ΔE00), lightness (ΔL’), chroma (ΔC’), hue differences (ΔH’), and whiteness index (WID). Results For enamel/dentin, the ΔE00 was significant among groups and periods (p<0.05). NeoMTA Plus had the greatest ΔE00. The NeoMTA Plus group had the greatest ΔE00 after two years for composite resin. Significant reduction in lightness was observed for all groups after two years (p<0.05). The most significant WID values were observed after 30 days for Biodentine (enamel/dentin) and MTA Repair HP groups (composite resin) (p<0.05). Conclusions The hCSCs changed the colorimetric behavior of both substrates, leading to greater darkening over time. The Bi2O3 in the Original MTA seems relevant in the short periods of color change assessment.

https://doi.org/10.1590/1678-7757-2022-0444

11.

Influence of anxiety and catastrophizing on pain perception in orthodontic treatment and its association with inflammatory cytokines
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Santos, Lucineide Lima dos

; Conti, Ana Cláudia de Castro Ferreira

; Fernandes, Thais Maria Freire

; Garlet, Gustavo Pompermaier

; Almeida, Marcio Rodrigues de

; Oltramari, Paula Vanessa Pedron

Brazilian Oral Research

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2023, Volume 37 elocation e010

Abstract: En | Text: En | PDF: En

Abstract Pain is common in orthodontic treatment, is subject to individual variation, and is associated with anxiety and stress, which can potentially become catastrophizing. The aim of the present study was to determine the variability of pain response after the insertion of orthodontic separators and to assess the association of pain levels with dental anxiety, catastrophizing, tooth sensitivity, and genetic expression of cytokines. To this end, 70 patients of both genders were divided into two equal groups according to the elastomeric separator used: G1 (Dentaurum) and G2 (Orthometric). Two separators were inserted in the mesial and distal sides of the lower right first molar. Participants were instructed to rate the level of pain at T0 (before insertion), T1 (just after insertion), and T2 (24 hours after insertion) on a visual analog scale. The gingival crevicular fluid was collected at T0 and T2. The levels of anxiety, catastrophizing, tooth sensitivity, and cytokine expression were also assessed. Statistical analysis was performed with the Fisher-Freeman-Halton, chi-squared, Spearman’s correlation, and dependent and independent t tests (α=5%). Pain intensity was higher at T2 than at T1, in both groups (P<.05). An association was established (P<.05) between pain intensity at T1 and catastrophizing, and at T2 with anxiety and catastrophizing. Within-group differences in cytokine expression were found between T0 and T2. There was no correlation between cytokine expression and pain levels, anxiety, catastrophizing, and sensitivity at T2. Tooth separation produced variable pain levels, which were influenced by anxiety and catastrophizing, however, pain level was not correlated with increased cytokine expression.

https://doi.org/10.1590/1807-3107bor-2023.vol37.0010

12.

Posicionamento Brasileiro sobre Síndrome da Quilomicronemia Familiar – 2023
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Izar, Maria Cristina de Oliveira

; Santos Filho, Raul Dias dos

; Assad, Marcelo Heitor Vieira

; Chagas, Antonio Carlos Palandri

; Toledo Júnior, Alceu de Oliveira

; Nogueira, Ana Cláudia Cavalcante

; Souto, Ana Cristina Carneiro Fernandes

; Lottenberg, Ana Maria

; Chacra, Ana Paula Marte

; Ferreira, Carlos Eduardo dos Santos

; Lourenço, Charles Marques

; Valerio, Cynthia Melissa

; Cintra, Dennys Esper

; Fonseca, Francisco Antonio Helfenstein

; Campana, Gustavo Aguiar

; Bianco, Henrique Tria

; Lima, Josivan Gomes de

; Castelo, Maria Helane Costa Gurgel

; Scartezini, Marileia

; Moretti, Miguel Antonio

; Barreto, Natasha Slhessarenko Fraife

; Maia, Rayana Elias

; Montenegro Junior, Renan Magalhães

; Alves, Renato Jorge

; Figueiredo, Roberta Marcondes Machado

; Fock, Rodrigo Ambrosio

; Martinez, Tânia Leme da Rocha

; Giraldez, Viviane Zorzanelli Rocha

Arquivos Brasileiros de Cardiologia

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2023, Volume 120 N. 4 elocation e20230203

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

https://doi.org/10.36660/abc.20230203

13.

Impact of high-fat diet consumption during prolonged period of pregnancy on placenta structures and umbilical vascular growth in goats
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Bezerra, Alessandra Façanha

; Alves, Juliana Paula Martins

; Fernandes, César Carneiro Linhares

; Cavalcanti, Camila Muniz

; Silva, Maria Raquel Lopes

; Conde, Alfredo José Herrera

; Palomino, Gaby Judith Quispe

; Teixeira, Dárcio Ítalo Alves

; Rego, Aníbal Coutinho do

; Rodrigues, Ana Paula Ribeiro

; Rondina, Davide

Animal Reproduction

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2023, Volume 20 N. 2 elocation e20230019

Abstract: En | Text: En | PDF: En

Abstract This study aimed to verify the impact of high-fat diet consumption for a prolonged period on oxidative stress, fetal growth, umbilical vascular system, and placental structures in pregnant goats. Twenty-two pregnant goats were grouped into the control diet (n= 11) and fat diet (n = 11). Flaxseed meal was added to the fat diet, replacing the corn grain of concentrate, from gestational day 100 to delivery date. Diets were isonitrogenous and isoenergetic, differing in fat content (2.8% vs. 6.3% dry matter). The fat group showed higher feed intake and total plasma lipid levels than the control group (P < 0.001). No difference was found in placentome, and umbilical vascular development. Fat diet-fed goats exhibited a lower systolic peak in the umbilical artery. At delivery, placental traits were similar with the exception of the cotyledon width (P = 0.0075), which was smaller in the fat group and cotyledon surface (P = 0.0047) for multiple pregnancy of fat diet. Cotyledonary epithelium showed more intense staining of lipid droplets and a greater area for lipofuscin staining in the fat group compared to control group (P < 0.001). The mean live weight of the kids was lower in the fat group in the first week after delivery than in control group. Thus, in goats, the continuous administration of a high-fat diet during pregnancy does not appear to modify the fetal-maternal vascular structures but has an impact on a part of the placental structure; therefore, its use must be carefully evaluated.

https://doi.org/10.1590/1984-3143-ar2023-0019

14.

Acurácia dos indicadores clínicos da proposta diagnóstica de enfermagem sobre o ressecamento ocular em terapia intensiva
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Araújo, Jéssica Naiara de Medeiros

; Botarelli, Fabiane Rocha

; Fernandes, Ana Paula Nunes de Lima

; Dantas, Ana Clara

; Lopes, Marcos Venícios de Oliveira

; Vitor, Allyne Fortes

Acta Paulista de Enfermagem

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2023, Volume 36 elocation eAPE024632

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

Abstract Objective To analyze the clinical indicator accuracy of Ocular dryness nursing diagnostic proposal in adult patients in the Intensive Care Unit. Methods This is a diagnostic accuracy study, with cross-sectional analytical design and quantitative approach. The sample consisted of 206 patients admitted to an adult Intensive Care Unit. An instrument designed according to variables related to sociodemographic and clinical data, clinical indicators, etiological factors, population at risk and associated conditions of Ocular dryness was applied. A latent class model was used to identify the prevalence of diagnosis and to identify clinical indicator specificity and sensitivity. Results Among the study participants, 52.4% were male and had a mean age of 58.69 years (±14.61). The prevalence of Ocular dryness was 76.22%. The reduced tear volume and excessive mucous secretion clinical indicators showed high specificity values (81.63% and 99.99%, respectively). Moreover, extended blood vessels on the ocular surface, excessive mucous secretion, mucoid filaments and chemosis presented higher values for sensitivity (74.52%, 99.99%, 100.0% and 71.97%, respectively). Conclusion After analyzing clinical indicator accuracy, it is concluded that five defining characteristics were able to present high values of specificity or sensitivity. This finding corroborates an accurate diagnostic inference, in order to enable the optimization of results in order to prevent the clinical decline related to the undesirable human response Ocular dryness .

Resumen Objetivo Analizar la precisión de los indicadores clínicos de la propuesta diagnóstica de enfermería Sequedad ocular en pacientes adultos en Unidad de Cuidados Intensivos. Métodos Estudio de precisión diagnóstica, con diseño analítico transversal y de enfoque cuantitativo. La muestra estuvo compuesta por 206 pacientes internados en una unidad de cuidados intensivos adulta. Se aplicó un instrumento elaborado de acuerdo con variables relacionadas con datos sociodemográficos, clínicos, indicadores clínicos, factores etiológicos, población en riesgo y condiciones asociadas a la sequedad ocular . Se utilizó un modelo de clase latente para identificar la prevalencia del diagnóstico y para identificar la especificidad y sensibilidad de los indicadores clínicos. Resultados De los participantes del estudio, el 52,4 % era de sexo masculino y con edad promedio de 58,69 años (±14,61). La prevalencia de la sequedad ocular fue de 76,22 %. Los indicadores clínicos volumen lagrimal reducido y exceso de secreción mucoide presentaron valores elevados de especificidad (81,63 % y 99,99 %, respectivamente). Además, vasos sanguíneos dilatados en la superficie ocular, exceso de secreción mucoide, filamento mucoide y quemosis presentaron valores más altos de sensibilidad (74,52 %, 99,99 %, 100,0 % y 71,97 %, respectivamente). Conclusión Después del análisis de precisión de los indicadores clínicos, se concluye que cinco características definitorias fueron capaces de presentar valores elevados de especificidad o sensibilidad. Este descubrimiento corrobora una inferencia diagnóstica precisa, a fin de permitir la optimización de resultados con el objetivo de impedir el deterioro clínico referente a la respuesta humana indeseable sequedad ocular .

Resumo Objetivo Analisar a acurácia dos indicadores clínicos da proposta diagnóstica de enfermagem Ressecamento ocular em pacientes adultos em Unidade de Terapia Intensiva. Métodos Estudo de acurácia diagnóstica, com delineamento analítico transversal e de abordagem quantitativa. A amostra foi composta por 206 pacientes internados em uma unidade de terapia intensiva adulto. Foi aplicado um instrumento elaborado de acordo com variáveis relacionadas aos dados sociodemográficos, clínicos, indicadores clínicos, fatores etiológicos, população em risco e condições associadas do Ressecamento ocular . Um modelo de classe latente foi utilizado para identificação da prevalência do diagnóstico e identificação da especificidade e sensibilidade dos indicadores clínicos. Resultados Dentre os participantes do estudo, 52,4% eram do sexo masculino e apresentaram média de idade de 58,69 anos (±14,61). A prevalência do Ressecamento ocular foi de 76,22%. Os indicadores clínicos volume lacrimal diminuído e excesso de secreção mucoide apresentaram valores elevados de especificidade (81,63% e 99,99%, respectivamente). Além disso, vasos sanguíneos dilatados na superfície ocular, excesso de secreção mucoide, filamento mucoide e quemose apresentaram valores mais altos para sensibilidade (74,52%, 99,99%, 100,0% e 71,97%, respectivamente). Conclusão Após a análise da acurácia dos indicadores clínicos, conclui-se que cinco características definidoras foram capazes de apresentar valores elevados de especificidade ou sensibilidade. Este achado corrobora para uma inferência diagnóstica acurada, de modo a possibilitar a otimização de resultados com o intuito de impedir o declínio clínico referente à resposta humana indesejável Ressecamento ocular .

https://doi.org/10.37689/acta-ape/2023ao024632

15.

Recommendations for the Screening of Breast Cancer of the Brazilian College of Radiology and Diagnostic Imaging, Brazilian Society of Mastology and Brazilian Federation of Gynecology and Obstetrics Association
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Urban, Linei Augusta Brolini Delle

; Chala, Luciano Fernandes

; Paula, Ivie Braga de

; Bauab, Selma di Pace

; Schaefer, Marcela Brisighelli

; Oliveira, Ana Lúcia Kefalás

; Shimizu, Carlos

; Oliveira, Tatiane Mendes Gonçalves de

; Moraes, Paula de Camargo

; Miranda, Beatriz Medicis Maranhão

; Aduan, Flávia Engel

; Rego, Salete de Jesus Fonseca

; Canella, Ellyete de Oliveira

; Couto, Henrique Lima

; Badan, Gustavo Machado

; Francisco, José Luis Esteves

; Moraes, Thaís Paiva

; Jakubiak, Rosangela Requi

; Peixoto, João Emílio

Revista Brasileira de Ginecologia e Obstetrícia

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2023, Volume 45 N. 8 Pages 480 - 488

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Objective To present the update of the recommendations of the Brazilian College of Radiology and Diagnostic Imaging, the Brazilian Society of Mastology and the Brazilian Federation of Associations of Gynecology and Obstetrics for breast cancer screening in Brazil. Methods Scientific evidence published in Medline, EMBASE, Cochrane Library, EBSCO, CINAHL and Lilacs databases between January 2012 and July 2022 was searched. Recommendations were based on this evidence by consensus of the expert committee of the three entities. Recommendations Annual mammography screening is recommended for women at usual risk aged 40–74 years. Above 75 years, it should be reserved for those with a life expectancy greater than seven years. Women at higher than usual risk, including those with dense breasts, with a personal history of atypical lobular hyperplasia, classic lobular carcinoma in situ, atypical ductal hyperplasia, treatment for breast cancer or chest irradiation before age 30, or even, carriers of a genetic mutation or with a strong family history, benefit from complementary screening, and should be considered individually. Tomosynthesis is a form of mammography and should be considered in screening whenever accessible and available.

Resumo Objetivo Apresentar a atualização das recomendações do Colégio Brasileiro de Radiologia e Diagnóstico por Imagem da Sociedade Brasileira de Mastologia e da Federação Brasileira das Associações de Ginecologia e Obstetrícia para o rastreamento do câncer de mama no Brasil. Métodos Foram pesquisadas evidências científicas publicadas nas bases de dados Medline EMBASE Biblioteca Cochrane EBSCO CINAHL e Lilacs entre janeiro de 2012 e julho de 2022. As recomendações foram baseadas nessas evidências por consenso do comitê de especialistas das três entidades. Recomendações A mamografia anual é recomendada para mulheres com risco habitual entre 40 e 74 anos. Acima de 75 anos deve ser reservado para aqueles com expectativa de vida superior a sete anos. Mulheres com risco maior do que o normal incluindo aquelas com mamas densas com história pessoal de hiperplasia lobular atípica carcinoma lobular in situ clássico hiperplasia ductal atípica tratamento para câncer de mama ou irradiação de tórax antes dos 30 anos ou ainda portadoras de doença genética mutação ou com forte histórico familiar beneficiam-se de triagem complementar e devem ser considerados individualmente. A tomossíntese é uma forma de mamografia e deve ser considerada na triagem sempre que acessível e disponível.

https://doi.org/10.1055/s-0043-1772498

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