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RESUMEN: Las proteínas S100 pertenecen al grupo de proteínas fijadoras de calcio y están presentes en actividades reguladoras fisiológicas intracelulares y extracelulares, como la diferenciación celular, y actúan en procesos patológicos inflamatorios y neoplásicos. Recientemente, sus expresiones en el sistema nervioso han sido ampliamente estudiadas, buscando dilucidar su acción a nivel del tálamo: una estructura del sistema nervioso central que forma parte de importantes circuitos, como el somatosensorial, conductual, de memoria y cognitivo, así como además de ser responsable de la transmisión y regulación de la información a la corteza cerebral. Este artículo es una revisión integradora de la literatura científica, que analizó 12 estudios presentes en Pubmed. El análisis mostró que la relación de las proteínas S100 y el tálamo ha sido descrita en procesos neoplásicos, trastornos mentales, hipoxia, trauma, estrés, infección, enfermedad de Parkinson y epilepsia. En resumen, es posible concluir que esta familia de proteínas es relevante como marcador en procesos de lesión talámica, requiriendo más estudios para comprender mejor su significado clínico, preclínico y su valor pronóstico.

SUMMARY: S100 proteins belong group of calcium-binding proteins and are present in physiological intracellular and extracellular regulatory activities, such as cell differentiation, and act in inflammatory and neoplastic pathological processes. Recently, its expressions in the nervous system have been extensively studied, seeking to elucidate its action at the level of the thalamus: A structure of the central nervous system that is part of important circuits, such as somatosensory, behavioral, memory and cognitive, as well as being responsible for the transmission and regulation of information to the cerebral cortex. This article is an integrative review of scientific literature, which analyzed 12 studies present in Pubmed. The analysis showed that the relationship of S100 proteins and the thalamus has been described in neoplastic processes, mental disorders, hypoxia, trauma, stress, infection, Parkinson's disease and epilepsy. In summary, it is possible to conclude that this protein family is relevant as a marker in processes of thalamic injury, requiring further studies to better understand its clinical, preclinical meanings and its prognostic value.

Non-Brazilian environmental perception on the Amazon rainforest: an approach using text mining from social media
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Souza, Cléber Rodrigo de

; da Silveira Junior, Wanderley Jorge

; Mariano, Ravi Fernandes

; Sousa Couto-Júnior, Antônio Carlos de

; Fontes, Marco Aurélio Leite

; Santos, Rubens Manoel dos

CERNE

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2023, Volume 29 elocation e-103261

Abstract: En | Text: En | PDF: En

ABSTRACT Background: The Amazon rainforest plays an essential role in sheltering global biodiversity and providing essential ecosystem services. However, the region has been threatened by increased rates of deforestation and degradation, which is often reported as the failure of the Brazilian conservation policy that could affect the image of agriculture Brazilian products abroad. In this sense, here we aimed to evaluate the foreign environmental perception of the region using data from social medias, to assess which are the main terms related to the region, how their importance varies over time and whether this perception tends to be more negative or positive. For this, we used data from posts made on Twitter® involving the term “Amazon rainforest” over 18 weeks using a data mining process. From these posts, we extracted the text, which went through steps of cleaning and organization, as well as crossing with additional databases (such as the sentiment dictionary). From the final data set, we first evaluated which are the main terms present in these posts and how their importance varied in the evaluated period. Next, we assess whether the terms cited are mainly negative or positive and how this sentiment varied over the monitoring period. Results: We found that the main terms are related to the environmental context such as “carbon”, “deforestation” and “fire” and that there is a relationship between their importance and the occurrence of fires in the region, which is positive with a temporal lag. In addition, we also found that the posts are, on average, composed of 68.47% of negative terms and that this sentiment predominates throughout the entire time series, being higher during the fire peaks in the region. Conclusion: Our results indicate that the environmental perception of the region presented in the posts in Twitter® is mainly negative, due to the degradation and fires observed over the last few years. We also discuss limitations of the approach and establish perspectives for future work.

https://doi.org/10.1590/01047760202329013261

Awareness towards stroke among high school students in Brazil: a cross-sectional study
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Rodrigues, Mateus de Sousa

; Santana, Leonardo Fernandes e

; Fernandes Castro, Alanderson Passos

; Almeida Coelho, Karyne Krysley

; Guimarães, Manoel Pereira

; Gomes, Orlando Vieira

; Schwingel, Paulo Adriano

; Cerqueira Filho, Renato Bispo de

; Guimarães, Marcos Duarte

; Moura, José Carlos de

Sao Paulo Medical Journal

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aug 2022, Volume 140 N. 4 Pages 525 - 530

Abstract: En | Text: En | PDF: En

ABSTRACT BACKGROUND: Stroke is one of the main causes of death worldwide. Educational interventions on stroke are potentially effective in reducing the period between the onset of symptoms and the initial emergency medical assistance. OBJECTIVES: To assess high school students’ knowledge of stroke. DESIGN AND SETTING: Cross-sectional study conducted in high schools in northeastern Brazil. METHODS: A self-structured questionnaire survey regarding stroke awareness was applied among high school students in northeastern Brazil. Data were collected between 2018 and 2019. The chi-square test and other descriptive statistics were used. Univariate and multivariate analyses were performed using logistic regression. RESULTS: A total of 1,788 students were analyzed. Eighty percent (n = 1430) of them did not have the minimum knowledge on how to act in a stroke situation. Only 10% (n = 179) presented the ideal knowledge on how to act. Males presented lower levels of knowledge on risk factors (odds ratio, OR: 0.62%; 95% confidence interval, CI: 0.49-0.79) and signs and symptoms of stroke (OR: 0.63%; 95% CI: 0.52-0.77). Students with ≥ 10 years of schooling (OR: 1.64%; 95% CI: 1.30-2.07) demonstrated greater knowledge of signs and symptoms of stroke. Students aged 18 years (OR: 1.70%; 95% CI: 1.14-2.52) demonstrated greater knowledge than other ages regarding the telephone number of the emergency medical services. CONCLUSIONS: There was a knowledge deficit with regard to recognizing stroke and activating the emergency medical services. The findings apply to the sample investigated and suggest that there is a need for stroke educational interventions, starting in high school.

https://doi.org/10.1590/1516-3180.2021.0659.r2.13102021

Response to: topical cyclosporine A 0.05% before and after surgery to prevent pterygium recurrence
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Alacamli, Goksu

; Meneghim, Roberta Lilian Fernandes de Sousa

; Satto, Larissa Horikawa

; Natsuaki, Kryscia Leiko

; Oliveira, Alessandro Carvalho de

; Padovani, Carlos Roberto

; Viveiros, Magda Massae Hata

; Schellini, Silvana Artioli

Arquivos Brasileiros de Oftalmologia

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apr 2022, Volume 85 N. 2 Pages 202 - 204

Abstract: En | Text: En | PDF: En

https://doi.org/10.5935/0004-2749.20220092

Migração para veia hepática de cateter totalmente implantável para quimioterapia em paciente com carcinoma de mama: relato de caso
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Silveira, Augusto Cesar Maia Rio Lima

; Fernandes, Paula Shelda Fonseca

; Fontinele, Danilo Rafael da Silva

; Costa, Rafael Everton Assunção Ribeiro da

; Araújo, José Eduardo Prado

; Sousa Junior, Wilson de Oliveira

; Vieira, Sabas Carlos

Jornal Vascular Brasileiro

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2022, Volume 21 elocation e20210189

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O cateter totalmente implantável (CTI) é utilizado na administração da quimioterapia. Em menos de 1% dos casos de complicação, pode ocorrer migração do CTI para quimioterapia para a circulação sistêmica. O objetivo deste estudo foi descrever um caso de migração do CTI para a veia hepática. Uma paciente do sexo feminino, de 44 anos de idade, teve diagnóstico de câncer de mama com indicação de quimioterapia neoadjuvante. Realizou-se a implantação de cateter port-a-cath. Durante o procedimento de punção do cateter, houve retorno normal de sangue, e foi realizada infusão de soro fisiológico. Em seguida, houve um aumento de volume no local do port e não retorno de sangue à aspiração. A radiografia de tórax mostrou embolização do cateter em topografia hepática. Retirou-se o cateter pela técnica do laço (sem complicações), e a paciente recebeu alta no dia seguinte. Possíveis alterações no funcionamento do CTI devem chamar atenção da equipe responsável.

Abstract A totally implantable venous access port (TIVAP) is used for chemotherapy administration. Venous port migration to the systemic circulation occurs in less than 1% of complications. The aim of this study is to describe a case of TIVAP migration to the hepatic vein. A 44-year-old female patient with breast cancer was prescribed neoadjuvant chemotherapy. A port-a-cath was surgically implanted for chemotherapy. During the port puncture procedure, blood returned normally when aspirated. When the port was first accessed and flushed with saline solution, swelling was observed at the port site and blood could no longer be aspirated. A chest radiography showed catheter embolization in the region of the hepatic vein. The catheter was retrieved using a snare technique (without complications) and the patient was discharged the next day. The care team should be alert to possible TIIVAP malfunction.

https://doi.org/10.1590/1677-5449.202101891

Ultrasound-guided percutaneous renal biopsy at a university hospital: retrospective analysis of success and complication rates
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Gomes, Orlando Vieira

; Almeida, Bianca Alencar Dias de

; Santana, Leonardo Fernandes e

; Rodrigues, Mateus de Sousa

; Locio, Guilherme Bruno Pires Marques

; Araújo, Carla Santos

; Rosas, Carlos Henrique de Sousa

; Guimarães, Marcos Duarte

Radiologia Brasileira

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oct 2021, Volume 54 N. 5 Pages 311 - 317

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Objetivo: Avaliar taxas de sucesso e de complicações de biópsias renais guiadas por ultrassonografia em um hospital terciário. Materiais e Métodos: Análise retrospectiva de 97 biópsias renais realizadas entre 1º de março de 2017 e 31 de outubro de 2019, guiadas por ultrassonografia e executadas por um único médico radiologista. Resultados: Oitenta e sete biópsias apresentaram diagnóstico anatomopatológico definitivo. Cinco biópsias foram inconclusivas (5,4%) e precisaram de um segundo procedimento. Houve complicações em sete procedimentos (7,6%), todas devidamente solucionadas. Conclusão: A biópsia renal guiada por ultrassonografia demonstrou ser um método efetivo e seguro para o diagnóstico de nefropatias, com elevada taxa de sucesso em sua execução.

Abstract Objective: To evaluate the success and complication rates of ultrasound-guided renal biopsy at a tertiary care hospital. Materials and Methods: This was a retrospective analysis of 97 ultrasound-guided renal biopsies, all performed by the same radiologist, between 1 March, 2017 and 31 October, 2019. Results: Of the 97 biopsies evaluated, 87 had a definitive pathological diagnosis. In five cases (5.4%), the biopsy results were inconclusive and a second procedure was required. In seven procedures (7.6%), there were complications, all of which were properly resolved. Conclusion: Ultrasound-guided renal biopsy has proven to be a safe, effective method for the diagnosis of nephropathies, with high success rates.

https://doi.org/10.1590/0100-3984.2020.0064 162 downloads

Primary health care nurses: attitudes towards the person with mental disorder
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Nóbrega, Maria do Perpétuo Socorro de Sousa

; Fernandes, Carla Sílvia Neves da Nova

; Zerbetto, Sonia Regina

; Sampaio, Francisco Miguel Correia

; Carvalho, José Carlos

; Chaves, Suellen Cristina da Silva

Revista Gaúcha de Enfermagem

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2021, Volume 42 elocation e20200088

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivo Identificar as atitudes dos enfermeiros que atuam na Atenção Primária à Saúde frente à pessoa com transtorno mental e as variáveis relacionados aos cuidados de saúde prestados. Metodologia Estudo descritivo, correlacional, com 250 enfermeiros de 69 Unidades Básica de Saúde do município de São Paulo. A coleta de dados ocorreu entre abril e agosto de 2019 por meio da escala “Opiniões acerca da Doença Mental”. Os dados foram analisados por meio do teste de KrusKal-Wallis, com nível de confiança de 95% e significância estatística de p<0,05. Resultados A média global da escala foi 197, que demonstra atitudes negativas especialmente nas dimensões de Autoritarismo (44,6), Restrição Social (42,0), e positiva na dimensão Benevolência (51,7). Conclusão Os enfermeiros apresentam, tendencialmente, perfil atitudinal estigmatizante. É necessária intervenção formativa e permanente para que seja possível reduzir o estigma e melhorar o cuidado de base comunitária preconizado nas diretrizes da Rede de Atenção Psicossocial.

ABSTRACT Objective To identify the attitudes of nurses working in Primary Health Care towards the person with mental disorder and the variables related to health care provided. Methodology Descriptive, correlational study with 250 nurses from 69 Basic Health Units in the city of São Paulo. Data collection took place between April and August 2019 using the “Opinions about Mental Illness” scale. The data were analyzed using the KrusKal-Wallis test, with a 95% confidence level and statistical significance of p <0.05. Results The global mean of the scale was 197, which shows negative attitudes especially in the dimensions of Authoritarianism (44.6), Social Restriction (42.0), and positive in the dimension of Benevolence (51.7). Conclusion Nurses tend to have a stigmatizing attitudinal profile. It is necessary formative and permanent intervention so that it is possible to reduce stigma and improve community-based care recommended in the guidelines of the Psychosocial Care Network.

RESUMEN Objetivo Identificar las actitudes de los enfermeros que trabajan en Atención Primaria de Salud frente a la persona con trastorno mental y las variables relacionadas con la atención médica brindada. Metodología Estudio descriptivo, correlacional con 250 enfermeras de 69 Unidades Básicas de Salud en la ciudad de São Paulo. La recopilación de datos tuvo lugar entre abril y agosto de 2019 utilizando la escala "Opiniones sobre enfermedades mentales". Los datos se analizaron mediante la prueba de KrusKal-Wallis, con un nivel de confianza del 95% y una significación estadística de p <0,05. Resultados El promedio global de la escala fue 197, lo que muestra actitudes negativas especialmente en las dimensiones de Autoritarismo (44.6), Restricción social (42.0), y positivas en la dimensión de Benevolencia (51.7). Conclusión Las enfermeras tienden a tener un perfil de actitud estigmatizante. La intervención formativa y permanente es necesaria para que sea posible reducir el estigma y mejorar la atención comunitaria recomendada en las pautas de la Red de Atención Psicosocial.

https://doi.org/10.1590/1983-1447.2021.20200088 300 downloads

Flies as possible vectors of inflammatory trachoma transmission in a Brazilian municipality
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Meneghim, Roberta Lilian Fernandes de Sousa

; Madeira, Newton Goulart

; Ribolla, Paulo Eduardo Martins

; Padovani, Carlos Roberto

; Schellini, Silvana Artioli

Revista do Instituto de Medicina Tropical de São Paulo

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2021, Volume 63 elocation e66

Abstract: En | Text: En | PDF: En

ABSTRACT Trachoma is a keratoconjunctivitis caused by Chlamydia trachomatis, considered an important leading cause of preventable blindness in the world. This study aimed at verifying if flies can be the vectors for trachoma in our municipality. Flies were assessed in the households of children diagnosed with inflammatory trachoma at the municipality of Botucatu, Sao Paulo State, Brazil. Fly traps were placed in the backyard of the houses during 24 h, in each of the four weather seasons, over a period of one year. The collected dipterans were taxonomically classified and the presence of Chlamydia trachomatis in the flies was evidenced by using the Polymerase Chain Reaction (PCR). During the studied period, 2,188 flies were collected, mainly during the summer and the spring. The most common identified fly was Musca domestica. All fly samples were negative for Chlamydia trachomatis but several other different bacteria were identified in these flies. The authors concluded that flies are probably not the vectors for trachoma in the studied area. Further studies should be conducted to evaluate other possible factors responsible for the maintenance of the disease in our environment.

https://doi.org/10.1590/s1678-9946202163066 108 downloads

NEI VFQ-25 questionnaire is an excellent option to evaluate the quality of life of Brazilian patients with cataract?
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Schaal, Luisa Fioravanti

; Meneghim, Roberta Lilian de Sousa Fernandes

; Rodrigues, Antonio Carlos Lotelli

; Padovani, Carlos Roberto

; Nunes, Hélio Rubens de Carvalho

; Schellini, Silvana Artioli

Arquivos Brasileiros de Oftalmologia

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sep 2020, Volume 83 N. 5 Pages 447 - 448

Abstract: En | Text: En | PDF: En

https://doi.org/10.5935/0004-2749.20200103 328 downloads

10.

Phenolic profiles of faveleira (Cnidoscolus quercifolius Pohl) seed and press cake extracts: potential for a new trend in functional food
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Ribeiro, Penha Patrícia Cabral

; Sousa Júnior, Francisco Canindé de

; Assis, Cristiane Fernandes de

; Veras, Bruno Oliveira de

; Padilha, Carlos Eduardo de Araújo

; Stamford, Thayza Christina Montenegro

; Damasceno, Karla Suzanne Florentino da Silva Chaves

Brazilian Journal of Food Technology

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2020, Volume 23 elocation e2019315

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O objetivo do presente estudo foi avaliar os compostos fenólicos e a capacidade antioxidante da semente e da torta da semente de faveleira. Os perfis fenólicos foram avaliados por cromatografia líquida de ultra alta eficiência. Além disso, o conteúdo fenólico total e a eliminação do radical DPPH (2,2-diphenyl-1-picrylhydrazyl) foram avaliados. A torta e a semente de faveleira são fontes de compostos fenólicos naturais para dieta humana e possuem potente atividade antioxidante. O ácido gálico foi o composto fenólico predominante na semente e na torta. O estudo mostrou que a torta e a semente de faveleira podem ser consideradas alimentos funcionais e de interesse potencial para a indústria de alimentos.

Abstract The objective of the present study was to assess the phenolic compounds and antioxidant capacity of faveleira seed and press cake extracts. Phenolic profiles were assessed by Ultra-High Performance Liquid Chromatography (UHPLC). Furthermore, the Total Phenolic Content (TPC) and DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging were evaluated. The faveleira seed and press cake extracts are sources of natural phenolic compounds in human diet and have potent antioxidant activity. Gallic acid was the predominant phenolic compound in seed and press cake extracts. The study showed that faveleira seed and press cake extracts can be considered functional foods as well as a potential interest to the food industry.

https://doi.org/10.1590/1981-6723.31519 498 downloads

11.

Pneumonia risk factors in stroke patients
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Mariano, Paulo Mateus Madureira Soares

; Rodrigues, Mateus de Sousa

; Santana, Leonardo Fernandes e

; Guimarães, Manoel Pereira

; Schwingel, Paulo Adriano

; Gomes, Orlando Vieira

; Moura, José Carlos de

Revista CEFAC

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2020, Volume 22 N. 6 elocation e9920

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: avaliar as características demográficas e clínicas associadas ao desenvolvimento de pneumonia em pacientes após acidente vascular encefálico internados em um hospital terciário do Vale do São Francisco que atende os estados de Pernambuco e Bahia, Brasil. Métodos: trata-se de estudo unicêntrico, observacional, analítico e transversal realizado a partir dos prontuários de pacientes com diagnóstico de acidente vascular encefálico incluídos no Registro de Acidente Vascular Encefálico (Estudo RAVESS). A análise estatística foi composta pelos testes qui-quadrado, exato de Fisher e a análise de variância com pós-teste de Bonferroni com nível de P≤0,05. Resultados: foram coletados dados de 69 pacientes com AVE agudo com média±desvio padrão de idade de 63,2±16,8 anos, sendo 37 (53,6%) do sexo feminino, com prevalência de pneumonia durante o internamento estimada em 31,9% (Intervalo de Confiança de 95%: 21,2-44,2%). Na análise univariada para preditores de pneumonia após acidente vascular encefálico foram identificados: idade mais avançada (72,6±17,9 vs. 58,8±14,5; P=0,001), menor sinal de resposta a escala de coma de Glasgow durante a admissão (11,3±1,8 vs. 13,3±2,1; P=0,001) e maior frequência de disartria na admissão (61,9% vs. 27,9%; P=0,009). Conclusão: a pneumonia foi uma complicação prevalente em pacientes após acidente vascular encefálico de um hospital terciário brasileiro, tendo sido relacionada com idade avançada do paciente e a severidade do evento encefálico.

ABSTRACT Purpose: to assess the demographic and clinical characteristics associated with the development of pneumonia in post-stroke patients hospitalized in a tertiary hospital, located in the Vale do São Francisco, that covers the states of Pernambuco and Bahia, Brazil. Methods: a unicentric, observational, analytical, cross-sectional study, based on the medical records of patients diagnosed with stroke and included in the Stroke Registry (RAVESS study). The statistical analysis was made with the chi-square test, Fisher’s exact test, and the analysis of variance, with the Bonferroni’s post-test, and P≤0.05. Results: data from 69 patients presented with acute stroke were collected, aged 63.2±16.8 years; 37 (53.6%) were females; the prevalence of pneumonia during hospital stay was estimated at 31.9% (95% confidence interval: 21.2-44.2%). In the univariate analysis of predictors for post-stroke pneumonia, the following were identified: older age (72.6±17.9 vs. 58.8±14.5; P = 0.001), lower response signal to the Glasgow Coma Scale at admission (11.3±1.8 vs. 13.3±2.1; P = 0.001), and higher frequency of dysarthria at admission (61.9% vs. 27.9%; P = 0.009). Conclusion: pneumonia was a prevalent complication in post-stroke patients at a Brazilian tertiary hospital. It was related to the patient’s older age and the severity of the cerebral event.

https://doi.org/10.1590/1982-0216/20202269920 1297 downloads

12.

Characteristics and outcomes of patients with COVID-19 admitted to the ICU in a university hospital in São Paulo, Brazil - study protocol
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Ferreira, Juliana C.

; Ho, Yeh-Li

; Besen, Bruno A.M.P.

; Malbuisson, Luiz M.S.

; Taniguchi, Leandro U.

; Mendes, Pedro V.

; Costa, Eduardo L.V.

; Park, Marcelo

; Daltro-Oliveira, Renato

; Roepke, Roberta M.L.

; Silva Jr, João M.

; Carmona, Maria José C.

; Carvalho, Carlos Roberto Ribeiro

; Hirota, Adriana

; Kanasiro, Alberto Kendy

; Crescenzi, Alessandra

; Fernandes, Amanda Coelho

; Miethke-Morais, Anna

; Bellintani, Arthur Petrillo

; Canasiro, Artur Ribeiro

; Carneiro, Bárbara Vieira

; Zanbon, Beatriz Keiko

; Batista, Bernardo Pinheiro De Senna Nogueira

; Nicolao, Bianca Ruiz

; Besen, Bruno Adler Maccagnan Pinheiro

; Biselli, Bruno

; Macedo, Bruno Rocha De

; Toledo, Caio Machado Gomes De

; Pompilio, Carlos Eduardo

; Carvalho, Carlos Roberto Ribeiro De

; Mol, Caroline Gomes

; Stipanich, Cassio

; Bueno, Caue Gasparotto

; Garzillo, Cibele

; Tanaka, Clarice

; Forte, Daniel Neves

; Joelsons, Daniel

; Robira, Daniele

; Costa, Eduardo Leite Vieira

; Silva Júnior, Elson Mendes Da

; Regalio, Fabiane Aliotti

; Segura, Gabriela Cardoso

; Marcelino, Gustavo Brasil

; Louro, Giulia Sefrin

; Ho, Yeh-Li

; Ferreira, Isabela Argollo

; Gois, Jeison de Oliveira

; Silva Junior, Joao Manoel Da

; Reusing Junior, Jose Otto

; Ribeiro, Julia Fray

; Ferreira, Juliana Carvalho

; Galleti, Karine Vusberg

; Silva, Katia Regina

; Isensee, Larissa Padrao

; Oliveira, Larissa dos Santos

; Taniguchi, Leandro Utino

; Letaif, Leila Suemi

; Lima, Lígia Trombetta

; Park, Lucas Yongsoo

; Chaves Netto, Lucas

; Nobrega, Luciana Cassimiro

; Haddad, Luciana

; Hajjar, Ludhmila

; Malbouisson, Luiz Marcelo

; Pandolfi, Manuela Cristina Adsuara

; Park, Marcelo

; Carmona, Maria José Carvalho

; Andrade, Maria Castilho Prandini H De

; Santos, Mariana Moreira

; Bateloche, Matheus Pereira

; Suiama, Mayra Akimi

; Oliveira, Mayron Faria de

; Sousa, Mayson Laercio

; Louvaes, Michelle

; Huemer, Natassja

; Mendes, Pedro

; Lins, Paulo Ricardo Gessolo

; Santos, Pedro Gaspar Dos

; Moreira, Pedro Ferreira Paiva

; Guazzelli, Renata Mello

; Reis, Renato Batista Dos

; Oliveira, Renato Daltro De

; Roepke, Roberta Muriel Longo

; Pedro, Rodolpho Augusto De Moura

; Kondo, Rodrigo

; Rached, Samia Zahi

; Fonseca, Sergio Roberto Silveira Da

; Borges, Thais Sousa

; Ferreira, Thalissa

; Cobello Junior, Vilson

; Sales, Vivian Vieira Tenório

; Ferreira, Willaby Serafim Cassa

Clinics

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2020, Volume 75 elocation e2294

Abstract: En | Text: En | PDF: En

OBJECTIVES: We designed a cohort study to describe characteristics and outcomes of patients with coronavirus disease (COVID-19) admitted to the intensive care unit (ICU) in the largest public hospital in Sao Paulo, Brazil, as Latin America becomes the epicenter of the pandemic. METHODS: This is the protocol for a study being conducted at an academic hospital in Brazil with 300 adult ICU beds dedicated to COVID-19 patients. We will include adult patients admitted to the ICU with suspected or confirmed COVID-19 during the study period. The main outcome is ICU survival at 28 days. Data will be collected prospectively and retrospectively by trained investigators from the hospital’s electronic medical records, using an electronic data capture tool. We will collect data on demographics, comorbidities, severity of disease, and laboratorial test results at admission. Information on the need for advanced life support and ventilator parameters will be collected during ICU stay. Patients will be followed up for 28 days in the ICU and 60 days in the hospital. We will plot Kaplan-Meier curves to estimate ICU and hospital survival and perform survival analysis using the Cox proportional hazards model to identify the main risk factors for mortality. ClinicalTrials.gov: NCT04378582. RESULTS: We expect to include a large sample of patients with COVID-19 admitted to the ICU and to be able to provide data on admission characteristics, use of advanced life support, ICU survival at 28 days, and hospital survival at 60 days. CONCLUSIONS: This study will provide epidemiological data about critically ill patients with COVID-19 in Brazil, which could inform health policy and resource allocation in low- and middle-income countries.

https://doi.org/10.6061/clinics/2020/e2294 1957 downloads

13.

Topical cyclosporine A 0.05% before and after surgery to prevent pterygium recurrence
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Meneghim, Roberta Lilian Fernandes de Sousa

; Satto, Larissa Horikawa

; Natsuaki, Kryscia Leiko

; Oliveira, Alessandro Carvalho de

; Padovani, Carlos Roberto

; Viveiros, Magda Massae Hata

; Schellini, Silvana Artioli

Arquivos Brasileiros de Oftalmologia

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oct 2019, Volume 82 N. 5 Pages 372 - 376

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Avaliamos os resultados da técnica de rotação de retalho conjuntival com uso de 5-fluorouracil e terapia adjuvante com ciclosporina A tópica a 0,05%, usada no pré e pós-operatório por curto período, quanto à prevenção da recidiva do pterígio primário Métodos: Estudo prospectivo, com 76 pacientes portadores de pterígio primário (76 olhos), divididos em dois grupos: controle com 31 pacientes que não receberam tratamento com ciclosporina e grupo ciclosporina com 45 pacientes que receberam ciclosporina tópica A (0,05%) duas vezes ao dia, por 10 dias antes e 10 dias após a cirurgia de excisão do pterígio. Os pacientes foram avaliados quanto à recorrência, efeitos colaterais e complicações com 10, 21 dias, 2 e 6 meses de pós-operatório. Dados demográficos, doenças sistêmicas e histórico oftalmológico foram coletados de todos os pacientes e esses dados foram analisados por meio de estatística descritiva envolvendo o percentual absoluto e relativo de distribuição de frequência. O teste de Goodman para contrastes entre populações multinomiais foi utilizado para o estudo da associação entre a ciclosporina A e a recorrência Resultados: A maioria dos pacientes tinha entre 30 e 60 anos e 67,1% eram mulheres. Confirmamos uma maior recorrência em pacientes com exposição ocupacional ao sol. A ciclosporina A tópica utilizada 10 dias antes e 10 dias após a remoção do pterígio não reduziu significativamente a sua recorrência Conclusão: A ciclosporina A tópica a 0,05% quando utilizada por 10 dias no pré e 10 dias no pós-operatório, não previne ou reduz a recidiva do pterígio primário significativamente.

ABSTRACT Purpose: We evaluated the role of the conjunctival flap rotation technique using 5-fluorouracil and adjuvant therapy with topical cyclosporine A at 0.05% during short pre- and postoperative periods for the prevention of primary pterygium recurrence. Methods: In this prospective study, 76 patients with primary pterygium (76 eyes) were categorized into two groups: the control group with 31 patients who did not receive cyclosporine treatment, and the cyclosporine group with 45 patients who received topical cyclosporine A (0.05%) twice a day, for 10 days before and 10 days after the pterygium excision operations. Patients were examined for disease recurrence, side effects, and complications at 10 and 21 days, and at 2 and 6 months after the operation. Data on demography, systemic diseases, and ophthalmologic histories were obtained from all patients, and these data were analyzed using descriptive statistics involving the absolute and relative percentages of frequency distribution. Goodman test was used for contrasts among multinomial populations to study the association between cyclosporine A and recurrence. Results: Most patients were between 30 and 60 years of age, and 67.1% were women. We confirmed a higher recurrence in patients with occupational sunlight exposure. The cyclosporine A used topically 10 days before and 10 days after the pterygium removal did not significantly reduce the recurrence of the pterygium. Conclusion: Topical 0.05% cyclosporine A when used for 10 days before and 10 days after the pterygium removal does not prevent or reduce the recurrence of primary pterygium.

https://doi.org/10.5935/0004-2749.20190075 1067 downloads

14.

Padrão do consumo de álcool entre trabalhadores de uma universidade pública brasileira
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Branco, Fernanda Matos Fernandes Castelo

; Farias, Francisca Luana de Sousa

; Dutok, Carlos Manuel Sanchez

; Neto, Tancredo Castelo Branco

; Vargas, Divane de

; Barroso, Tereza Maria Mendes Diniz de Andrade

Revista de Enfermagem Referência

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sep 2019, Volume serIV N. 22 Pages 85 - 95

Abstract: Es Pt En | Text: Es Pt En | PDF: Es | PDF: Pt | PDF: En

Marco contextual: El alcohol es un producto lícito, de fácil acceso, ampliamente utilizado y considerado un problema de salud pública mundial. Por ello, existe una creciente preocupación por el consumo de alcohol entre los trabajadores de las instituciones educativas. Objetivo: Identificar el patrón de consumo de alcohol entre los trabajadores de una universidad pública. Metodología: Estudio transversal. Se aplicaron 53 cuestionarios en línea a técnicos administrativos y profesores de una universidad pública del norte de Brasil, y se evaluaron a través de la prueba Alcohol Use Disorders Identification Test (AUDIT). Se aplicó la prueba de la ji al cuadrado y la prueba exacta de Fisher, con el valor p = 0,05 para probar el nivel de significación de las variables y la puntuación AUDIT. Resultados: Entre los participantes, el 68% muestra un uso de bajo riesgo o no consume, el 24% un consumo de riesgo, el 2% un consumo nocivo y el 6% una posible dependencia. Solo la variable tener hijos tenía una asociación estadística con el consumo problemático de alcohol. Conclusión: Los resultados sugirieron un consumo problemático de alcohol en una parte significativa de la muestra estudiada, lo que requirió la implementación de intervenciones breves en la población estudiada.

Enquadramento: O álcool é uma droga lícita, de fácil acesso, amplamente utilizada e considerada um problema de saúde pública mundial. Assim, há uma crescente preocupação com este consumo entre os trabalhadores das instituições de ensino. Objetivo: Identificar o padrão do consumo de álcool nos trabalhadores de uma universidade pública. Metodologia: Estudo transversal. Foram aplicados 53 questionários online, a técnicos administrativos e docentes de uma universidade pública no norte do Brasil, avaliados através do Alcohol Use Disorders Identification Test (AUDIT). Aplicou-se o teste qui-quadrado e exato de Fisher, com p-value = 0,05 para testar o nível de significância das variáveis e o score do AUDIT. Resultados: De entre os participantes, 68% têm uma utilização de baixo risco ou não consomem, 24% apresentam consumo de risco, 2% consumo nocivo e 6% provável dependência. Apenas a variável possuir filhos apresentou associação estatística com uso problemático de álcool. Conclusão: Os resultados sugeriram um consumo problemático de álcool numa parcela significativa da amostra estudada, sendo necessária a implementação de intervenções breves na população estudada.

Background: Alcohol is an easily accessible legal drug, widely used, and considered a public health problem worldwide. Therefore, there is a growing concern with this consumption among employees of educational institutions. Objective: To identify the pattern of consumption of alcohol among employees of a public university. Methodology: A cross-sectional study. Fifty-three online questionnaires were applied to administrative technicians and lecturers of a public university in northern Brazil, evaluated through the Alcohol Use Disorders Identification Test (AUDIT). The chi-squared test and Fisher's exact test were used, with a p-value of = 0.05 to test the level of significance of the variables and the AUDIT score. Results: Among the participants, 68% have a low-risk use or do not consume alcohol, 24% present a risky use, 2% harmful consumption, and 6% probable dependence. Only the children variable showed a statistical association with the problematic use of alcohol. Conclusion: The results suggest a problematic consumption of alcohol in a significant portion of the sample studied, resulting in the need for the implementation of brief interventions in the population studied.

https://doi.org/10.12707/RIV19026 715 downloads

15.

Modeling of tree recruitment by artificial neural networks after wood harvesting in a forest in eastern Amazon rain forest
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Reis, Leonardo Pequeno

; Souza, Agostinho Lopes de

; Reis, Pamella Carolline Marques dos Reis

; Mazzei, Lucas

; Leite, Helio Garcia

; Soares, Carlos Pedro Boechat

; Torres, Carlos Moreira Miquelino Eleto

; Silva, Liniker Fernandes da

; Ruschel, Ademir Roberto

; Rêgo, Lyvia Julienne Sousa

Ciência Florestal

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jun 2019, Volume 29 N. 2 Pages 583 - 594

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo A modelagem do recrutamento em florestais tropicais é importante para estudos de sustentabilidade do manejo florestal, por dar subsídio adequado à recuperação do estoque de madeira. O objetivo do trabalho foi estimar o recrutamento após a colheita de madeira, empregando um modelo de rede neural artificial (RNA). A área de estudo está localizada na Floresta Nacional do Tapajós (55°00’ W, 2°45’ S), Pará. Em 64 ha da área de estudo, em 1979, foi realizada colheita intensiva de 72,5 m3 ha-1. Em 1981 foram instaladas, aleatoriamente, 36 parcelas permanentes de 50 m x 50 m. Essas parcelas foram mensuradas em 1982, 1983, 1985, 1987, 1992, 1997, 2007, 2010 e 2012. Para modelar o recrutamento foram consideradas as variáveis da subparcela-alvo e a sua vizinhança. As estimativas obtidas no treino e na generalização da RNA foram avaliadas pelas estatísticas: correlação () e raiz quadrada do erro quadrático médio (RQRQM), sendo obtido RQRQM 35,6% e 0,89. Foi possível modelar a tendência do recrutamento ao longo do tempo em florestas tropicais, após a colheita de madeira.

Abstract Recruitment models in tropical forests are important for studies on forest management sustainability because they provide adequate support to recovery of wood stocks. The objective of this work was to estimate recruitment after wood harvesting by using an artificial neural network (ANN) model. The study area is located at Tapajós National Forest (55° 00’ W, 2° 45’ S), Pará state. In 64 ha of the study area, in 1979, an intensive harvest of 72.5 m3 ha-1 was carried out. In 1981, 36 permanent plots of 50 m x 50 m were randomly installed. These plots were measured in 1982, 1983, 1985, 1987, 1992, 1997, 2007, 2010 and 2012. For recruitment modeling, the variables of the target subplot and its vicinity were considered. The estimates obtained in ANN training and generalization were evaluated by statistics: correlation () and root mean square error (RMSE) were determined: RMSE 35.6% and 0.89. Recruitment tendency could be modeled over time in tropical forests after wood harvesting.

https://doi.org/10.5902/1980509825808 694 downloads

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