Resumen Introducción : Se ha descrito que alteraciones molecu lares de las células foliculares tiroideas en el gen BRAF o en NRAS están asociadas con el proceso de carcinogé nesis. Nuestro objetivo fue conocer la frecuencia muta cional de BRAF y NRAS a partir de muestras de punción aspirativa con aguja fina (PAAF) en nuestra población. Métodos : Se analizó por qPCR el estado mutacional de BRAF (codón 600) y NRAS (codón 61) de 193 mues tras obtenidas por PAAF de nódulos sospechosos y se comparó con los datos de la anatomía patológica de 115 pacientes. Resultados : La mutación BRAF se identificó en 40 muestras (74.1%) de las punciones categorizadas como Bethesda VI (n = 54). En las muestras que se correspon dieron con carcinoma papilar de tiroides (CPT) variante clásica por histología (n = 47), el 70% presentó la muta ción, mientras que en los otros subtipos la prevalencia fue más baja (p = 0.013). En muestras de lesión folicular (n = 36), el 50% de los carcinomas foliculares resultaron positivos para NRAS pero solo el 6.7% de los adenomas presentaron esta variación. La presencia de mutación BRAF y CPT se asociaron con metástasis en los gan glios linfáticos (p = 0.014) y mayor riesgo relativo de recurrencia según el Consenso Argentino Intersocietario (RR = 6.77, p = 0.022). No hubo diferencias significativas entre la mutación de BRAF y otras características de agresividad en CPT. Conclusión : La mutación de BRAF y NRAS se observa en un número significativo de CPT y carcinoma folicular, respectivamente, en nuestra población. La mutación BRAF se correlaciona significativamente con metástasis en los ganglios linfáticos.

Abstract Introduction : Molecular alterations in follicular cells in the BRAF or NRAS genes have been reported to be associated with the process of carcinogenesis. Our aim was to determine the mutational frequency of BRAF and NRAS in fine-needle aspiration (FNA) specimens in our population. Methods : The mutational status of BRAF (codon 600) and NRAS (codon 61) was analysed by qPCR in 193 FNA specimens from suspicious nodules and compared with pathological data of 115 patients. Results : BRAF mutation was identified in 40 samples (74.1%) of FNAs classified as Bethesda VI (n = 54). In samples histologically diagnosed as classic papillary thyroid carcinoma (cPTC, n = 47), mutation was observed in 70% of cases, while in other subtypes the prevalence was lower (p = 0.013). In FNA specimens of follicular lesions (n = 36), positivity for NRAS was found in 50% of the follicular carcinomas (FTCs), but only in 6.7% of adenomas. Finally, there was a significant correlation between BRAF and PTC with lymph-node metastasis (p = 0.014) and increased relative risk of recurrence based on the Argentine Intersociety Consensus (RR = 6.77, p = 0.022). No significant differences were found between BRAF mutation and other features of aggressiveness in PTC. Conclusion : BRAF and NRAS mutations are observed in a significant number of PTCs and FTCs, in our popu lation. There is a significant correlation between BRAF mutation and lymph-node metastasis.

Abstract Introduction Depression in aging may lead to loss of autonomy and worsening of comorbidities. Understanding how positive attributes contribute to healthier and happier aging has been one ofthe purposes of Positive Psychology. However, the literature still lacks studies that evaluate how depression in the elderly is related to constructs considered positive. Objective The present study aimed comparing scores of constructs of spiritual well-being, social support, selfesteem, life satisfaction, affection, optimism, and hope in the elderly with minimal, mild, moderate, and severe depression and healthy controls in order to investigate possible indirect and mediated relationships between positive constructs and depression. Methods A cross-sectional study was conducted with elderly, 62 of whom were diagnosed with different severity of Major Depression (DSM-V) (minimum, mild, moderate, and severe according to the Beck Depression Inventory — BDI) and 66 healthy controls matched by age, sex and schooling. The instruments used were adapted and validated versions of the Spirituality Self-Rating Scale, the Rosenberg Self-Esteem Scale, the Medical Outcomes Social Scale of Support, the Life Satisfaction Scale, the Positive and Negative Affect Schedule, the Revised Life Orientation Test, and the Adult Dispositional Hope Scale. After comparing the means of scores between groups, an analysis of normalized partial association networks was performed to investigate the direct and mediated relationships between depression and other evaluated constructs. Results Scores of spiritual well-being, social support, self-esteem, life satisfaction, positive affect, optimism, negative affects, and hope differed significantly between the control group and the degrees of depression (p < 0.001). The analysis of normalized partial association networks has shown that the relations of depression with the constructs of life satisfaction, self-esteem, and social support are mediated, while the constructs of dispositional hope, positive affect, spiritual well-being, and optimism are indirectly related to depression. The social class was also positively related to depression. Conclusion Depression in different degrees is associated with a reduction in the scores of instruments that evaluate positive attributes. The constructs directly associated with depression are spiritual well-being, optimism, positive affect, and dispositional hope. The others had mediated relationship. These results may contribute to the planning of future interventions for the prevention of depression among the elderly.

ABSTRACT Objective: DATASUS is the Brazilian Public Unified Health System (SUS) department responsible for providing health data that are used as a primary source of data in several studies on surgery and surgical specialties although its main limitations have not been previously reviewed. The objective of this work is to synthesize information from studies on surgery that used DATASUS systems as a data source and to identify the main gaps in this platform. Methods: a scoping review was conducted according to the PRISMA-ScR method to identify papers on surgery, and other surgical specialties, that used the DATASUS platform as a primary data source. No restrictions were imposed regarding the type of study or year of publication. Grounded Theory was used to analyze the content of the articles. Results: 248 works were initially analyzed and 47 were included in the final analysis of this study. The original articles included were published between 2009 and 2022 and the majority (12.76%, n=6) were published in the Journal of the Brazilian College of Surgeons. Retrospective studies (40.43%, n=19) were the most common type of study found. Content analysis of the articles identified four predominant domains in the scientific literature about the limitations of using DATASUS in surgical research: lack of data, reliability, precision and data integration. Conclusion: the information systems available in DATASUS are the largest source of information about the SUS, but the scientific literature on the quality of data available in these systems remains scarce and studies aimed at measuring this metric are necessary.

RESUMO Objetivo: o DATASUS é o departamento do SUS responsável por disponibilizar dados de saúde que são empregados como fonte primária de dados em diversos estudos sobre cirurgia e especialidades cirúrgicas, embora principais limitações não tenham sido revisadas anteriormente. O objetivo deste trabalho é sintetizar as informações de estudos sobre cirurgia que utilizaram sistemas do DATASUS como fonte de dados, identificando as principais lacunas. Métodos: uma revisão de escopo foi conduzida de acordo com o método PRISMA-ScR para a identificação de trabalhos sobre cirurgia, e outras especialidade cirúrgicas, que utilizaram a plataforma DATASUS como fonte primária de dados. Nenhuma restrição foi imposta em relação ao tipo de estudo ou ano de publicação. A Teoria Fundamentada em Dados foi utilizada para a análise do conteúdo dos artigos. Resultados: 248 trabalhos foram inicialmente analisados e 47 foram incluídos na análise final deste estudo. Os artigos originais incluídos foram publicados entre 2009 e 2022, maioria (12,76%, n=6) foi publicada na Revista do Colégio Brasileiro de Cirurgiões. Estudos retrospectivos (40,43%, n=19) foram o tipo de estudo mais comum encontrado. A análise dos artigos identificou quatro domínios predominantes na literatura científica acerca das limitações do uso de DATASUS em pesquisas em cirurgia: falta de dados, confiabilidade, precisão e integralização dos dados. Conclusão: os sistemas de informação dispostos no DATASUS constituem a maior fonte de informações sobre o SUS, porém a literatura científica sobre a qualidade dos dados dispostos nestes sistemas permanece escassa e trabalhos direcionados a mensurar essa métrica são necessários.

Abstract The aim of this study was to develop and achieve consensus on a cariology teaching framework for dental schools in Latin American Spanish-speaking countries. The Delphi process, with a ≥8 0% pre-defined participants’ agreement, included three phases and a Coordinating Group. During the Preparation phase three panels of experts were selected and invited to participate: a) Regional academic/professional Dental Associations (Associations-Panel): n = 12; b) Regional Dental Schools (Dental-Schools-Panel): existing dental schools (n = 263) from the 19 Spanish-speaking regional countries; c) International academic/professional associations Peer Experts (Peer-Panel): n = 4. Based on consensus documents from Europe, Colombia, the Caribbean, USA, Chile and Spain, and updated scientific evidence, the Coordinating Group developed a baseline framework proposal of domains, main competencies (MC) and specific competencies (SC). The Consultation-Agreement and Consensus phases included three rounds of questionnaires with a step-wise sharing of the MC updated version of the consensus framework with the Dental-Schools-Panel and including SC with the Associations-Panel. Diverse communication strategies were used ( e.g ., independent google-form questionnaires and workshops). Consensus was reached after an on-site Associations-Panel workshop and secret voting, followed by an online meeting with the Peers-Panel. A total of 127 academic/professional institutions participated (Associations-Panel: 11, 91.6%; Dental-Schools-Panel: 112, 42.6%, all countries; Peers-Panel: 4, 100%). The baseline Cariology teaching framework of 5 domains, 10 MC and 92 SC underwent modifications after agreements for a final consensus framework consisting of 5 domains, 10 MC and 85 SC. A Core Cariology curriculum framework in Spanish for Latin American Dental Schools was successfully developed and agreed upon with regional dental academic and professional institutions.

Abstract The aim of this study was to determine the level of agreement between estimation equations with the 1RM method in a sample of 30 experienced young people. Four exercises were performed: barbell squat (SQ), horizontal bench press (BP), dead weight (DW), and military press (MiP), with a minimum and a maximum of 1 to 7 repetitions respectively. Six prediction equations were considered: Brzycki (1993), Epley (1995), Lander (1985), Cummings and Finn (1998), O'Conner et al. (1989), and Abadie et al. (1999). The mean and standard deviation were calculated, as well as the level of intraclass correlation and the Bland-Altman method to study the association. The mean values of 1RM obtained very good correlation in the equations of Brzycki (1993) and O'Conner et al. (1989) in the SQ, Epley (1995) in the BP exercise, and Cummings and Finn (1998) in the DW exercise. The predictive equation of Cummings and Finn (1998) and Epley (1995) can also be used to calculate 1RM in MiP. To improve the dosage of loads, it is recommended to use the predictive equations according to the exercise to be performed.

Resumen El objetivo de este trabajo fue conocer el nivel de concordancia entre ecuaciones de estimación con el método de 1 RM en una muestra de 30 jóvenes experimentados. Se ejecutaron cuatro ejercicios: sentadilla con barra libre (SEN), press en banco horizontal (PB), peso muerto (PMu) y press militar (PMi) teniendo un mínimo y un máximo de 1 a 7 repeticiones respectivamente. Se consideraron 6 ecuaciones de predicción: Brzycki (1993), Epley (1995), Lander (1985), Cummings y Finn (1998), O´Conner et al. (1989), y Abadie et al. (1999). Se calculó la media y desviación estándar, así como el nivel de correlación intraclase para estudiar el nivel de la asociación y el método Bland-Altman. Los valores medios de 1RM obtuvieron muy buena correlación en las ecuaciones de Brzycki (1993) y O´Conner et al. (1989) en el ejercicio de SEN, Epley (1995), Brzycki (1993), O´Conner et al. (1989) y Cumming y Finn (1998) en el ejercicio de PB, y Cummings y Finn (1998) en el ejercicio de PMu. La ecuación predictiva de Cummings y Finn (1998) y Epley (1995) también puede ser usada para calcular 1RM en el PMi. Para mejorar la dosificación de cargas, se recomienda utilizar las ecuaciones de predicción de acuerdo con el ejercicio que se quiera llevar a cabo.

Resumo O objetivo deste trabalho foi conhecer o nível de concordância entre as equações de estimação e o método de 1RM numa amostra de 30 jovens experientes. Foram executados quatro exercícios: agachamento com barra livre (SEN, por suas siglas em espanhol), press em banco horizontal (PB), peso morto (PMu) e press militar (PMi) com um mínimo e um máximo de 1 a 7 repetições, respectivamente. Foram consideradas 6 equações de predição: Brzycki (1993), Epley (1995), Lander (1985), Cummings e Finn (1998), O'Conner et al. (1989), e Abadie et al. (1999). Foram calculadas a média e o desvio estândar, e também o nível de correlação intraclasse e o método de Bland-Altman para analisar a associação. Os valores médios de 1RM conseguiram uma boa correlação nas equações de Brzycki (1993) e O'Conner et al. (1989) no exercício de SEN, Epley (1995) no exercício de PB, e Cummings e Finn (1998) no exercício de PMu. A equação preditiva de Cummings e Finn (1998) e Epley (1995) também é possível ser utilizada para calcular 1RM no PMi. Para melhorar a dosificação de cargas, é recomendável utilizar as equações de predição de acordo com o exercício que se deseje executar.

Dado 0 < s ≤ 1 e uma função s-convexa ψ, os espaços de sequencias s – ψ são introduzidos. Vários espaços quase-Banach de sequencias são assim caracterizados como um caso particular dos espaços s – ψ. Para esses espaços novas medidas de não compacidade são também definidas, relacionadas a medida de não compacidade de Hausdorff. Como uma aplicação, conjuntos compactos nos espa, cos de interpolação s – ψ, de um par quase-Banach são estudados.

Given 0 < s ≤ 1 and ψ an s-convex function, s – ψ -sequence spaces are introduced. Several quasi-Banach sequence spaces are thus characterized as a particular case of s – ψ -spaces. For these spaces, new measures of noncompactness are also defined, related to the Hausdorff measure of noncompactness. As an application, compact sets in s – ψ -interpolation spaces of a quasi-Banach couple are studied.

O objetivo deste artigo é discutir um modelo conceitual de comunicação da informação aplicável a estudos de interação entre usuário e bibliotecário, baseado em "competências conversacionais" em serviço de referência. Na ciência da informação, o fenômeno das "competências conversacionais" estaria no âmbito da transferência ou da comunicação da informação? Seria o modelo de Shannon e Weaver o mais apropriado para explicar esse fenômeno? Refletindo-se sobre a primeira pergunta, parece haver certa confusão conceitual, quando o assunto é comunicação da informação em ciência da informação. Utilizou-se Barreto (2005) e Pinheiro e Loureiro (1995), como base para a discussão desse aspecto. Com relação à segunda pergunta, talvez, a explicação da adoção do modelo de Shannon e Weaver na ciência da informação se dê pelo estudo dos paradigmas. Como as pesquisas iniciais da ciência da informação, em meados dos anos 50, estavam mais focadas no paradigma físico da recuperação da informação e o modelo de Shannon e Weaver surge mais ou menos na mesma época, a apropriação foi quase imediata. Mas, com a inserção de outros paradigmas, como o cognitivo e o social nos estudos na ciência da informação, o modelo de Shannon e Weaver passou a ser desconstruído e reconstruído sob novas óticas.

The aim of this paper is to discuss a conceptual model of communication of information applicable to studies of the interaction between user and librarian based on "conversational competencies" in a reference service. In information science would the phenomenon of "conversational skills" be in the transfer or communication of information? Would Shannon and Weaver 's model be the most appropriate to explain this phenomenon? Reflecting on that first question, there seems to be a conceptual confusion when the subject is communication of information in information science. We used Barreto (2005) and Pinheiro and Loureiro (1995) as a basis for the discussion of the first question. Regarding the second question, perhaps explaining the adoption of the model of Shannon and Weaver in information science is given through the study of paradigms. Since the early research of information science in the mid-50s were more focused on the physical paradigm of information retrieval and the model of Shannon and Weaver appears at approximately the same time its appropriation was almost immediate. But, with the inclusion of other paradigms such as cognitive and social paradigms in the studies of information science, and also with the emergence of other theories in science communication, the model of Shannon and Weaver came to be deconstructed and rebuilt under new perspectives.

OBJETIVO: Investigar a correlação entre as manobras de estiramento do nervo ciático, como o Teste de Lasègue (TL) e o Teste de Elevação da Perna Estendida (TEPE), com os achados cirúrgicos nos pacientes com ciatalgia. MÉTODOS: 178 pacientes portadores de hérnia de disco lombar foram examinados previamente pelo autor através do TL e do TEPE. Os achados cirúrgicos foram anotados e comparados com os achados do exame clínico. RESULTADOS: Dos pacientes estudados, 162 (91%) apresentaram TL positivo enquanto 118 (66,2%) apresentaram a TEPE positivo. CONCLUSÃO: O TL foi a manobra diagnóstica pré-operatória mais sensível em correlação com a hérnia discal lombar.

OBJECTIVE: To investigate the correlation between maneuversfor stretching the sciatic nerve, as the Lasègue Sign (LS) and the Straight-Leg-Raising Test (SLRT), with surgical findings in patients with sciatica. METHODS: 178 patients with herniated lumbar disc were previously examined by the author through LS and SLRT. Surgical findings were recorded and compared with findings on clinical examination. RESULTS: Of the patients studied, 162 (91%) had positive LS while 118 (66.2%) were positive to SLRT. CONCLUSION: The LS was the most sensitive preoperative physical diagnostic test with respect to intraoperative pathology of lumbar disc herniation.

OBJETIVO: Investigar la correlación entre las maniobras de estiramiento del nervio ciático, como la Prueba de Lasègue (PL) y la Prueba de Elevación de la Pierna Extendida (PEPE), con los resultados quirúrgicos en pacientes con ciática. MÉTODOS: 178 pacientes con hernia discal lumbar fueron examinados previamente por el autor mediante la PL y la PEPE. Los resultados quirúrgicos fueron registrados y comparados con los hallazgos en el examen clínico. RESULTADOS: De los pacientes estudiados, 162 (91%) fueron positivos en la PL, mientras que 118 (66,2%) presentaron PEPE positiva. CONCLUSIÓN: La PL fue la maniobra de diagnóstico preoperatorio más sensible en correlación con hernia discal lumbar.