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Objective: To test the hypothesis that genetic variations of cannabinoid receptors contribute to the pathophysiology of cognitive deficits in schizophrenia. Methods: In this genetic association case-control study, cannabinoid receptor polymorphisms CNR1 rs12720071 and CNR2 rs2229579 were tested for association with neurocognitive performance in 69 patients with schizophrenia and 45 healthy controls. Neurocognition was assessed by the Brief Assessment of Cognition in Schizophrenia (BACS). Results: We found a consistent association between CNR1 rs12720071 polymorphism and the cognitive performance of patients in several cognitive domains. Patients with C/C polymorphism presented significantly worse performance in motor speed, verbal fluency, attention/processing speed and reasoning/problem solving. Conclusion: Although limited, our data support the hypothesis that CNR1 variations may be associated with the pathogenesis of cognitive deficits of schizophrenia.

https://doi.org/10.1590/1516-4446-2020-1650

Heterogeneous Photocatalysis with Niobium Doped-Titanium Substrates Treated by Plasma Electrolytic Oxidation
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Orsetti, Fábio R.

; Gonçalves, Thaís M.

; Sottovia, Lívia

; Figueiredo, Elaine B.

; Ferrari, Ana M.

; Rangel, Elidiane C.

; Cruz, Nilson C.

Materials Research

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2022, Volume 25 elocation e20220391

Abstract: En | Text: En | PDF: En

Plasma Electrolytic Oxidation (PEO) was employed for the generation of porous niobium-containing surfaces with enhanced photocatalytic activity. Pulses of 500 and 600 V, with a repetition rate of 60 Hz, were applied to titanium disks immersed in niobium-containing electrolytic solutions. The treatment time ranged from 180 to 600 s, and the surface morphology was analyzed by scanning electron microscopy, while X-ray diffraction was employed in the evaluation of crystallographic structure. The optical gap of the samples was determined from UV-Vis reflection spectra, and an automated goniometer was used for contact angle and surface energy measurements. More than 35% of Nb has been incorporated into the samples. Under certain conditions, the treatments resulted in a reduction of the optical gap from 3.18 to 2.63 eV as compared to as-received samples. Photocatalytic degradation rates of methylene blue as high as 70% have been reached after 120 minutes under irradiation with UV-Vis light.

https://doi.org/10.1590/1980-5373-mr-2022-0391

Atualização da Diretriz Brasileira de Hipercolesterolemia Familiar – 2021
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Izar, Maria Cristina de Oliveira

; Giraldez, Viviane Zorzanelli Rocha

; Bertolami, Adriana

; Santos Filho, Raul Dias dos

; Lottenberg, Ana Maria

; Assad, Marcelo Heitor Vieira

; Saraiva, José Francisco Kerr

; Chacra, Ana Paula M.

; Martinez, Tania L. R.

; Bahia, Luciana Ribeiro

; Fonseca, Francisco Antonio Helfenstein

; Faludi, Andre Arpad

; Sposito, Andrei C.

; Chagas, Antônio Carlos Palandri

; Jannes, Cinthia Elim

; Amaral, Cristiane Kovacs

; Araújo, Daniel Branco de

; Cintra, Dennys Esper

; Coutinho, Elaine dos Reis

; Cesena, Fernando

; Xavier, Hermes Toros

; Mota, Isabela Cardoso Pimentel

; Giuliano, Isabela de Carlos Back

; Faria Neto, José Rocha

; Kato, Juliana Tieko

; Bertolami, Marcelo Chiara

; Miname, Marcio Hiroshi

; Castelo, Maria Helane Costa Gurgel

; Lavrador, Maria Sílvia Ferrari

; Machado, Roberta Marcondes

; Souza, Patrícia Guedes de

; Alves, Renato Jorge

; Machado, Valeria Arruda

; Salgado Filho, Wilson

Arquivos Brasileiros de Cardiologia

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oct 2021, Volume 117 N. 4 Pages 782 - 844

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20210788 231 downloads

Associação entre Terapia com Estatinas e Menor Incidência de Hiperglicemia em Pacientes Internados com Síndromes Coronarianas Agudas
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Furtado, Remo Holanda de Mendonça

; Genestreti, Paulo Rizzo

; Dalçóquio, Talia F.

; Baracioli, Luciano Moreira

; Lima, Felipe Galego

; Franci, André

; Giraldez, Roberto R. C. V.

; Menezes, Fernando R.

; Ferrari, Aline Gehlen

; Lima, Viviane Moreira

; Pereira, Cesar A. C.

; Nakashima, Carlos Alberto Kenji

; Salsoso, Rocio

; Godoy, Lucas Colombo

; Nicolau, José C.

Arquivos Brasileiros de Cardiologia

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feb 2021, Volume 116 N. 2 Pages 285 - 294

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Fundamento O maior risco de se desenvolver diabetes com o uso de estatinas é um desafio para a segurança do uso dessa classe de medicamentos em longo prazo. No entanto, poucos estudos analisaram essa questão durante síndromes coronarianas agudas (SCA). Objetivos Investigar a associação entre início precoce da terapia com estatina e níveis de glicemia em pacientes admitidos com SCA. Métodos Este foi um estudo retrospectivo de pacientes hospitalizados por SCA. Pacientes que nunca haviam usado estatinas foram incluídos e divididos segundo uso ou não de estatina nas primeiras 24 horas de internação. O desfecho primário foi a incidência de hiperglicemia na internação (definida como pico de glicemia > 200mg/dL). Modelos de regressão logística e modelos lineares multivariados foram usados para ajuste quanto a fatores de confusão e um modelo de pareamento por escore de propensão foi desenvolvido para comparações entre os dois grupos de interesses. Um valor de p menor que 0,05 foi considerado estatisticamente significativo. Resultados Um total de 2357 pacientes foram incluídos, 1704 deles alocados no grupo que receberam estatinas e 653 no grupo que não receberam estatinas nas primeiras 24 horas de internação. Após os ajustes, uso de estatina nas primeiras 24 horas foi associado com uma menor incidência de hiperglicemia durante a internação (OR ajustado = 0,61, IC95% 0,46-0,80; p < 0,001) e menor necessidade de uso de insulina (OR ajustado = 0,56, IC 95% 0,41-0,76; p < 0,001). Essas associações mantiveram-se similares nos modelos de pareamento por escore de propensão, bem como após análises de sensibilidade, como exclusão de pacientes que desenvolveram choque cardiogênico, infecção grave ou pacientes que foram a óbito durante a internação hospitalar. Conclusões Entre os pacientes internados com SCA que não receberam estatinas previamente, a terapia precoce com estatina associou-se independentemente com menor incidência de hiperglicemia durante a internação. (Arq Bras Cardiol. 2021; 116(2):285-294)

Abstract Background Increased risk of new-onset diabetes with statins challenges the long-term safety of this drug class. However, few reports have analyzed this issue during acute coronary syndromes (ACS). Objective To explore the association between early initiation of statin therapy and blood glucose levels in patients admitted with ACS. Methods This was a retrospective analysis of patients hospitalized with ACS. Statin-naïve patients were included and divided according to their use or not of statins within the first 24 hours of hospitalization. The primary endpoint was incidence of in-hospital hyperglycemia (defined as peak blood glucose > 200 mg/dL). Multivariable linear and logistic regression models were used to adjust for confounders, and a propensity-score matching model was developed to further compare both groups of interest. A p-value of less than 0.05 was considered statistically significant. Results A total of 2,357 patients were included, 1,704 of them allocated in the statin group and 653 in the non-statin group. After adjustments, statin use in the first 24 hours was associated with a lower incidence of in-hospital hyperglycemia (adjusted OR=0.61, 95% CI 0.46-0.80; p < 0.001) and lower need for insulin therapy (adjusted OR = 0.56, 95% CI 0.41-0.76; p < 0.001). These associations remained similar in the propensity-score matching models, as well as after several sensitivity analyses, such as after excluding patients who developed cardiogenic shock, severe infection or who died during index-hospitalization. Conclusions Among statin-naïve patients admitted with ACS, early statin therapy was independently associated with lower incidence of in-hospital hyperglycemia. (Arq Bras Cardiol. 2021; 116(2):285-294)

https://doi.org/10.36660/abc.20200128 548 downloads

Factors associated with actively working in the very long-term following acute coronary syndrome
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Nicolau, Jose C.

; Furtado, Remo H.M.

; Dalçóquio, Talia F.

; Lara, Livia M.

; Juliasz, Marcela G.

; Ferrari, Aline G.

; Nakashima, Carlos A.K.

; Franci, Andre

; Pereira, Cesar A.C.

; Lima, Felipe G.

; Giraldez, Roberto R.

; Salsoso, Rocío

; Baracioli, Luciano M.

; Goodman, Shaun

Clinics

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2021, Volume 76 elocation e2553

Abstract: En | Text: En | PDF: En

OBJECTIVES: Returning to work after an episode of acute coronary syndrome (ACS) is challenging for many patients, and has both personal and social impacts. There are limited data regarding the working status in the very long-term after ACS. METHODS: We retrospectively analyzed 1,632 patients who were working prior to hospitalization for ACS in a quaternary hospital and were followed-up for up to 17 years. Adjusted models were developed to analyze the variables independently associated with actively working at the last contact, and a prognostic predictive index for not working at follow-up was developed. RESULTS: The following variables were significantly and independently associated with actively working at the last contact: age>median (hazard-ratio [HR], 0.76, p<0.001); male sex (HR, 1.52, p<0.001); government health insurance (HR, 1.36, p<0.001); history of angina (HR, 0.69, p<0.001) or myocardial infarction (MI) (HR, 0.76, p=0.005); smoking (HR, 0.81, p=0.015); ST-elevation MI (HR, 0.81, p=0.021); anterior-wall MI (HR, 0.75, p=0.001); non-primary percutaneous coronary intervention (PCI) (HR, 0.77, p=0.002); fibrinolysis (HR, 0.61, p<0.001); cardiogenic shock (HR, 0.60, p=0.023); statin (HR, 3.01, p<0.001), beta-blocker (HR, 1.26, p=0.020), angiotensin-converting enzyme (ACE) inhibitor/angiotensin II receptor blocker (ARB) (HR, 1.37, p=0.001) at hospital discharge; and MI at follow-up (HR, 0.72, p=0.001). The probability of not working at the last contact ranged from 24.2% for patients with no variables, up to 80% for patients with six or more variables. CONCLUSIONS: In patients discharged after ACS, prior and in-hospital clinical variables, as well as the quality of care at discharge, have a great impact on the long-term probability of actively working.

https://doi.org/10.6061/clinics/2021/e2553 494 downloads

Stabilized mortar with air incorporator agent and plasticizer set retarder: performance measurement
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SCHACKOW, A.

; FERRARI, A. K.

; EFFTING, C.

; ALVES, V. O.

; GOMES, I. R.

Revista IBRACON de Estruturas e Materiais

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dec 2019, Volume 12 N. 6 Pages 1248 - 1259

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Este estudo tem como objetivo desenvolver três argamassas estabilizadas para alvenaria com aditivo incorporador de ar e plastificante retardador de pega para comparar com uma argamassa convencional com cal. Foi analisado o índice de consistência, a massa específica, o teor de ar incorporado, a retenção da água, o tempo de pega através do calor de hidratação, a retração/expansão da argamassa, a resistência à compressão, a resistência ao sulfato e a resistência de aderência à tração. Os resultados mostraram que a presença do plastificante retardador de pega afetou o índice de consistência, tornando a argamassa trabalhável por mais tempo. A presença de aditivos tornou as argamassas estabilizadas mais leves, com menor densidade e maior teor de ar incorporado. A presença da cal proporcionou alta retenção de água na argamassa convencional, enquanto o plastificante retardador de pega melhorou a retenção de água nas argamassas estabilizadas. O tempo inicial de pega das argamassas estabilizadas ocorreu após aproximadamente 50 horas. A argamassa convencional perdeu sua trabalhabilidade rapidamente após 2 horas. Na argamassa convencional, ocorreu retração, enquanto que nas argamassas estabilizadas houve expansão. A argamassa convencional apresentou melhor resistência à compressão, enquanto que o excesso de aditivos pode ter afetado negativamente essa propriedade nas argamassas estabilizadas. A argamassa convencional mostrou-se menos resistente ao ataque por sulfato. A resistência de aderência à tração foi melhor na argamassa comercial estabilizada testada.

Abstract This study aims to develop three stabilized mortars to masonry using air entraining agents and settling retardant plasticizer to compare with a conventional mortar with lime. It was analyzed consistency index, specific gravity, air entrained content, water retentivity, setting time through the heat of hydration, mortar shrinkage/expansion, compressive strength, resistance to sulphate and tensile strength in bonding. The results exhibited that the presence of the settling retardant plasticizer affected the consistency index making the mortar more workable for a longer time. The presence of additives made the stabilized mortars lighter with lower mass density and higher incorporated air content. The presence of lime provided high water retentivity in the conventional mortar while the setting retardant plasticizer improved the water retentivity in the stabilized mortars. The initial setting time of the stabilized mortars occurred after approximately 50 hours. Conventional mortar lost its workability quickly after 2 hours. In conventional mortar, shrinkage occurred, while stabilized mortars had expansion. The conventional mortar exhibited better compressive strength, while the excess of additives can affected negatively this property in the stabilized mortars. Conventional mortar proved to be less resistant to sulphate attack. Tensile strength in bonding was better in a stabilized commercial mortar tested.

https://doi.org/10.1590/s1983-41952019000600002 1152 downloads

Physicochemical, biological and release studies of chitosan membranes incorporated with Euphorbia umbellata fraction
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Lemes, Bruna M.

; Novatski, Andressa

; Ferrari, Priscileila C.

; Minozzo, Bruno R.

; Justo, Aline da S.

; Petry, Victor E.K.

; Vellosa, José C.R.

; Sabino, Simone do R.F.

; Gunha, Jaqueline V.

; Esmerino, Luís A.

; Beltrame, Flávio L.

Revista Brasileira de Farmacognosia

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aug 2018, Volume 28 N. 4 Pages 433 - 443

Abstract: En | Text: En | PDF: En

Abstract Formulations containing chitosan incorporated with methanolic fraction of Euphorbia umbellata (Pax) Bruyns, Euphorbiaceae, were studied aiming future applications of this new material as medicine. In order to investigate potential interactions between chitosan and the methanolic fraction (10, 50 and 100% in relation to the amount of chitosan) physicochemical characterization was performed by scanning electron microscopy, density, differential scanning calorimetry, thermogravimetry, X-ray diffraction, Fourier-transform infrared spectroscopy and colorimetry techniques. The phenolic compounds released from the chitosan membranes were evaluated using the Folin-Ciocalteau quantification method; antioxidant and antimicrobial activity were also studied. Increasing amounts of the methanolic fraction added to polymeric matrix produced different numbers of pores on the surface of the membranes, changes in the calorimetric, spectroscopic and crystalline properties as well as color changes, when compared to the inert membrane. These changes can be attributed to chemical interactions that occurred between the structure of the chitosan and the phenolic compounds present in the studied fraction. The matrix samples incorporated with 50 and 100% of the methanolic fraction presented different release profiles of phenolic compounds from the membranes (controlled manner) and promoted antioxidant and antimicrobial activity.

https://doi.org/10.1016/j.bjp.2018.05.001 584 downloads

EFEITO DA ESTRUTURA MOLECULAR DE LIGANTES DE SUPERFÍCIE EM PONTOS QUÂNTICOS DE CdTe DISPERSOS EM ÁGUA
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Vale, Brener R. C.

; Vieira, Kayo O.

; Sousa, José C. L.

; Ferrari, Jefferson L.

; Schiavon, Marco A.

Química Nova

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jan 2015, Volume 38 N. 1 Pages 22 - 29

Abstract: Pt | Text: Pt | PDF: Pt

Water-soluble CdTe quantum dots are synthesized to investigate how short-chain surface ligands bearing -SH, -COOH, and -NH2 groups interact with CdTe during nucleation/growth processes. Their optical properties and colloidal stability after the ligand exchange are also investigated. We then characterize the resulting CdTe by fluorescence, UV–Vis absorption, and infrared spectroscopies. The stability of the colloidal dispersions was determined by their Zeta potentials. The results show that in the synthesis of water-soluble CdTe, surface ligands with at least two functional groups are required and the hard/soft character of them is an important factor in the stability of CdTe.

https://doi.org/10.5935/0100-4042.20140292 2309 downloads

Transmission of a 1.12 Tb/s superchannel over 452 km fiber
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Pataca, Daniel Moutinho

; Carvalho, Luis Henrique Hecker de

; Adami, Cristiane Brandani Ferrari

; Simões, Fabio Donati

; Rocha, Mônica de Lacerda

; Oliveira, Júlio C. R. F.

Journal of Microwaves, Optoelectronics and Electromagnetic Applications

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dec 2013, Volume 12 N. 2 Pages 524 - 532

Abstract: En | Text: En | PDF: En

This paper describes the transmission of a non-guard interval 1.12 Tb/s 10-carrier superchannel, launched into a 226 km recirculating loop. After two round trips (452 km) a BER below the FEC limit (3.8 x 10-3) was still obtained. To evaluate the superchannel generation technique, up to 72 comb lines (OSNRmin = 12.7 dB) were generated and modulated (DP-QPSK) at 112.5 Gb/s and, in a back-to-back configuration, such an 8.06 Tb/s signal was detected by a coherent receiver with offline processing, resulting in a maximum BER of 2.4 x 10-3.

2800 downloads

10.

Ultrasonografía doppler transcraneal urgente: utilidad predictiva del vasoespasmo sintomático en la hemorragia subaracnoidea espontánea en pacientes con buena situación neurológica
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Muñoz-Sánchez, M.A.

; Murillo-Cabezas, F.

; Egea-Guerrero, J.J.

; Gascón-Castillo, M.L.

; Cancela, P.

; Amaya-Villar, R.

; Rincón-Ferrari, M.D.

; Flores-Cordero, J.M.

; Cayuela, A.

; García-Alfaro, C.

Medicina Intensiva

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dec 2012, Volume 36 N. 9 Pages 611 - 618

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Purpose: To examine the predictive value of an early transcranial Doppler ultrasound (TCD) study performed in the emergency department in patients with spontaneous subarachoniod hemorrhage (SAH) in good neurological condition, in order to know which patients are at high risk of developing delayed cerebral ischemia (DCI). Design: A descriptive observational study was carried out involving a period of 3 years. Setting: Critical Care and Emergency Department. Patients: The study consecutively included patients with SAH of grade I-III on the Hunt and Hess scale. Variables of Interest: DCI (decrease of 2 points in GCS or focal deficit), Mean Velocity (MV) of middle cerebral arteries (MCA), Lindegaard Index (IL). Sonographic vasospasm pattern (SVP) was considered if MCA-MV>120cm/sc and IL>3. Results: The mean age of the 122 patients was 54.1±13.7 years; 57.3% were women. SVP was detected in 24 patients (19.7%), although high velocities patterns (HVP) were present in 38 patients (31.1%). DCI developed in 21 patients (MV183+/-49cm/sc), all with previous SVP. In this group MV increased 22+/-5cm/sc/day during the first 3 days. The group without HVP (84 patients/MV of 67+/-16.6cm/sc), compared with DCI group, showed differences in highest MV (p<0.001), and also ΔMV/day (8.30+/-4,5cm/sc Vs 22+/-5cm/sc) during the first 3 days (p=0.009). In our series, ROC analysis selected the best cut-off value for ΔMV/day as 21cm/sc (p<0.001). Conclusion: During the first 3 days, an increase of 21cm/s/24h in MCA-MV was associated with the development of symptomatic vasospasm. TCD is a useful tool for the early detection of patients at risk of DCI after SAH.

Objetivo: Establecer el valor predictivo, para desarrollar deterioro neurológico tardío de origen isquémico (DNI), de un estudio doppler transcraneal (DTC) en pacientes con hemorragia subaracnoidea espontánea (HSA) en buena situación neurológica. Diseño: Estudio descriptivo-observacional desarrollado durante 3 años. Ámbito: Cuidados Críticos y Urgencias. Pacientes: Se incluyeron de forma consecutiva aquellos pacientes con HSA en buena situación neurológica (Hunt-Hess I-III). Variables de Interés: DNI (disminución en 2 puntos del GCS o déficit focal), velocidad media (VM) en arterias cerebrales medias, índice de Lindegaard (IL). Se consideró patrón sonográfico de vasoespasmo (PSV) cuando la VM fue>120cm/s y existía un IL>3. Resultados: La media de edad de los 122 pacientes fue de 54,1±13,7 años. El 57,3% eran mujeres. Se detectaron 24 pacientes con PSV (19,7%) encontrándose VM elevadas en 38 pacientes (31,1%). 21 pacientes desarrollaron DNI (VM 183+/-49cm/s), todos presentaron PSV. En los pacientes con DNI se detectó un aumento de VM de 22+/-5cm/s/24h durante los 3 primeros días. Al comparar aquellos pacientes que no presentaron VM elevadas (85 pacientes/VM 67+/-16,6cm/s) con respecto a los que desarrollaron DNI encontramos diferencias en las VM (p<0,001) y en el ΔVM/24h (8,30+/-4,5cm/s Vs 22+/-5cm/s) durante los 3 primeros días (p=0,009). Mediante curvas ROC, se fijó que el ΔVM/día de 21cm/s (p<0,001), era el que mejor predecía el DNI. Conclusión: Durante los 3 primeros días un incremento en la VM de 21cm/s/24h se asoció con el desarrollo de vasoespamo sintomático. El DTC es una herramienta útil para la detección de aquellos pacientes con HSA en riesgo de desarrollar DNI.

https://doi.org/10.1016/j.medin.2012.01.013 2138 downloads

11.

Toxicological evaluation of ethanolic extract of Lychnophora trichocarpha, Brazilian arnica
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Ferrari, Fernanda C.

; Grabe-Guimarães, Andrea

; Carneiro, Cláudia M.

; Souza, Maíra R. de

; Ferreira, Leidiane C.

; Oliveira, Tânia T. de

; Saúde-Guimarães, Dênia A.

Revista Brasileira de Farmacognosia

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oct 2012, Volume 22 N. 5 Pages 1104 - 1110

Abstract: En | Text: En | PDF: En

The species of the genus Lychnophora, Asteraceae, are popularly known as "arnica" and are native from Brazilian savana (Cerrado). They are widely used in Brazilian folk medicine as anti-inflammatory, to treat bruise, pain, rheumatism and for insect bites. For evaluation of acute toxicity, the ethanolic extract was given to albino female and male mice. In open-field test, the extract of Lychnophora trichocarpha (Spreng.) Spreng. (0.750 g/kg) induced a significant inhibition of the spontaneous locomotor activity and exploratory behavior of the animals were observed 1 and 4 h after administration. In traction test, the same dose reduced the muscular force 1 h after administration. The exploratory behavior reduced significantly in the group that received 0.50 g/kg, 1 and 4 h after administration of the extract. The animals that received the doses of 0.25, 0.50 and 0.75 g/kg did not show any change of blood biochemical parameters comparing to control group and showed some histopathological changes such as congestion and inflammation of kidney and liver. The dose of 1.5 g/kg caused the most serious signs of toxicity. Histopathological changes observed was hemorrhage in 62.5% and pulmonary congestion in 100% of the animals. Brain and liver congestion was found in 62.5% of the animals.

2451 downloads

12.

Modificações da adiposidade em escolares de acordo com o estado nutricional: análise de 20 anos
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Ferrari, Tatiane K.

; Ferrari, Gerson Luis de M.

; Silva Júnior, João Pedro da

; Silva, Leonardo José da

; Oliveira, Luís C.

; Matsudo, Victor K. R.

Jornal de Pediatria

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jun 2012, Volume 88 N. 3 Pages 239 - 245

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

OBJETIVO: Analisar as modificações da adiposidade de escolares durante 20 anos, de acordo com o estado nutricional. MÉTODOS: O estudo faz parte do Projeto Misto Longitudinal de Crescimento, Desenvolvimento e Aptidão Física de Ilhabela. Uma amostra de 1.095 escolares de ambos os sexos, de 7 a 10 anos, atendiam aos seguintes critérios de inclusão: (a) pelo menos uma avaliação completa em um dos períodos analisados; (b) estar no estágio pré-púbere de maturação sexual; (c) ser aparentemente saudável. Os períodos analisados foram 1990/1991 (inicial), 2000/2001 (10 anos) e 2010/2011 (20 anos). As variáveis analisadas foram: massa corporal, estatura e adiposidade, pela análise individual de cada dobra cutânea. Os indivíduos foram classificados em eutróficos, com excesso de peso e obesos mediante as curvas propostas pela Organização Mundial da Saúde de índice de massa corporal para idade e sexo. Foi utilizada a Anova one-way, seguida do post-hoc de Scheffé, com p < 0,01. RESULTADOS: Nos meninos, o maior aumento ocorreu no grupo com excesso de peso, seguido pelos grupos obesos e eutróficos. Já nas meninas, os maiores aumentos ocorreram nos grupos com excesso de peso e eutróficas, seguidos pelo grupo obesas. CONCLUSÃO: Houve modificações da adiposidade, mesmo com o controle do estado nutricional, durante o período de 20 anos analisado, mostrando que os indivíduos que têm semelhantes índices de massa corporal podem variar em proporção e distribuição de tecido adiposo subcutâneo. Para ambos os sexos, o aumento foi maior nos grupos classificados como excesso de peso e, principalmente, nas dobras cutâneas centrais.

OBJECTIVE: To analyze adiposity changes in school-age children over a 20 year-period, according to nutritional status. METHODS: The study is part of the Ilhabela Longitudinal Mixed Project on Growth, Development and Physical Fitness. A sample of 1,095 school students of both sexes, from 7 to 10 years, met the following inclusion criteria: (a) at least one complete assessment in one of the analyzed periods; (b) to be in prepubertal stage of sexual maturation; (c) to be apparently healthy. The periods analyzed were 1990/1991 (initial), 2000/2001 (10 years) and 2010/2011 (20 years). The variables analyzed were: body weight, height and adiposity through individual analysis of each skinfold. Children were classified as eutrophic, overweight and obese, according to the curves of body mass index for age and sex proposed by the World Health Organization. The statistical analysis used was one-way ANOVA, followed by Scheffé's post-hoc test, with p < 0.01. RESULTS: In boys, the largest increase occurred in the overweight group, followed by the obese and eutrophic groups. In girls, the largest increases occurred in the groups with overweight and eutrophic children, followed by the obese group. CONCLUSION: in adiposity, even when the nutritional status was controlled, showing that individuals who have similar body mass indexes may vary in proportion and distribution of subcutaneous adipose tissue. In both sexes, the increase was higher in the overweight group, and mainly in central skinfolds.

https://doi.org/10.2223/JPED.2191 3743 downloads

13.

Ciprofloxacin susceptibility reduction of Salmonella strains isolated from outbreaks
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Souza, Roberta B.

; Ferrari, Rafaela G.

; Magnani, Marciane

; Kottwitz, Luciana B. M.

; Alcocer, Iliana

; Tognim, Maria Cristina B.

; Oliveira, Tereza C. R. M.

Brazilian Journal of Microbiology

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jun 2010, Volume 41 N. 2 Pages 497 - 500

Abstract: En | Text: En | PDF: En

The antimicrobial susceptibility of 212 Salmonella strains isolated from patients and foods was evaluated and 45% were found to be resistant to nalidixic acid. Nalidixic acid resistant strains showed a higher minimal inhibitory concentration for ciprofloxacin than sensitive strains. During the study an increase of strains with reduced susceptibility to ciprofloxacin was also observed.

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14.

Phase stability analysis of liquid-liquid equilibrium with stochastic methods
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Nagatani, G.

; Ferrari, J.

; Cardozo Filho, L.

; Rossi, C. C. R. S.

; Guirardello, R.

; Oliveira, J. Vladimir

; Corazza, M. L.

Brazilian Journal of Chemical Engineering

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sep 2008, Volume 25 N. 3 Pages 571 - 583

Abstract: En | Text: En | PDF: En

Minimization of Gibbs free energy using activity coefficient models and nonlinear equation solution techniques is commonly applied to phase stability problems. However, when conventional techniques, such as the Newton-Raphson method, are employed, serious convergence problems may arise. Due to the existence of multiple solutions, several problems can be found in modeling liquid-liquid equilibrium of multicomponent systems, which are highly dependent on the initial guess. In this work phase stability analysis of liquid-liquid equilibrium is investigated using the NRTL model. For this purpose, two distinct stochastic numerical algorithms are employed to minimize the tangent plane distance of Gibbs free energy: a subdivision algorithm that can find all roots of nonlinear equations for liquid-liquid stability analysis and the Simulated Annealing method. Results obtained in this work for the two stochastic algorithms are compared with those of the Interval Newton method from the literature. Several different binary and multicomponent systems from the literature were successfully investigated.

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15.

Structure and properties of Ti4+-ureasil organic-inorganic hybrids
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Molina, Celso

; Dahmouche, Karim

; Hammer, Peter

; Bermudez, Verónica de Zea

; Carlos, Luís D.

; Ferrari, Maurizio

; Montagna, Maurizio

; Gonçalves, Rogéria R.

; Oliveira, Luiz. F. C. de

; Edwards, Howell. G. M.

; Messaddeq, Younes

; Ribeiro, Sidney J. L.

Journal of the Brazilian Chemical Society

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jun 2006, Volume 17 N. 3 Pages 443 - 452

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Guias de luz planares foram obtidos a partir de um sol de um novo híbrido Ti4+-acetilacetona (acac)-Ureasil depositado na forma de filmes finos sobre substratos de vidro. A estrutura foi investigada por medidas espectroscópicas (absorção no infravermelho, fotoelétrons de raios-X e espalhamento Raman) e espalhamento de raios-X a baixos ângulos (SAXS). Para a adição do complexo Ti-acac ao ureasil na razão molar Ti:Si de 1:1 interações entre o complexo Ti-acac e grupos siloxanos foram identificadas. Quantidades maiores de Ti4+ (razão molar Ti:Si de 5:1) levam também à formação de nanoagregados ricos em titânio. Os parâmetros ópticos dos guias, como índice de refração, espessura, modos propagados e coeficiente de atenuação foram medidos para 632,8, 543,5 e 1550 nm pela técnica de acoplamento de prisma. O índice de refração pode ser controlado pela quantidade relativa de titânio. Guias de poucos micra de espessura suportam modos de propagação com baixas perdas para todas as composições.

Hybrid planar waveguides were prepared from Ti4+-acetylacetone (acac)-Ureasil sols deposited on glass substrates. Structural features have been investigated by spectroscopic measurements (Fourier Transform Infrared Spectroscopy (FTIR), X-ray Photoelectron Spectroscopy (XPS) and Raman scattering) and Small Angle X-ray Scattering (SAXS). Addition of Ti4+-acac to the ureasil (Ti:Si molar ratio 1:1) leads to the formation of bonds between the Ti complex and the siloxane groups, whereas further addition of Ti4+ (Ti:Si molar ratio 5:1) leads to the additional formation of titanium-rich nanoclusters. The optical parameters of the waveguides such as refractive index, thickness, propagating modes and attenuation coefficient were measured at 632.8, 543.5 and 1550 nm by the prism coupling technique. The refractive index can be tuned by the Ti4+ relative content. The few microns thick planar waveguides support well confined propagating modes with low attenuation loss for all compositions.

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