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Objectives: To summarize evidence-based cognitive-behavioral therapy (CBT) treatment and propose clinical interventions for adult patients with obsessive-compulsive disorder (OCD). Methods: The literature on CBT interventions for adult OCD, including BT and exposure and response prevention, was systematically reviewed to develop updated clinical guidelines for clinicians, providing comprehensive details about the necessary procedures for the CBT protocol. We searched the literature from 2013-2020 in five databases (PubMed, Cochrane, Embase, PsycINFO, and Lilacs) regarding study design, primary outcome measures, publication type, and language. Selected articles were assessed for quality with validated tools. Treatment recommendations were classified according to levels of evidence developed by the American College of Cardiology and the American Heart Association. Results: We examined 44 new studies used to update the 2013 American Psychiatric Association guidelines. High-quality evidence supports CBT with exposure and response prevention techniques as a first-line treatment for OCD. Protocols for Internet-delivered CBT have also proven efficacious for adults with OCD. Conclusion: High-quality scientific evidence supports the use of CBT with exposure and response prevention to treat adults with OCD.

https://doi.org/10.47626/1516-4446-2023-3081

Brazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders guidelines for the treatment of adult obsessive-compulsive disorder. Part I: pharmacological treatment
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de Oliveira, Marcos Vinícius Sousa

; de Barros, Pedro Macul Ferreira

; de Mathis, Maria Alice

; Boavista, Rodrigo

; Chacon, Priscila

; Echevarria, Marco Antonio Nocito

; Ferrão, Ygor Arzeno

; Vattimo, Edoardo Felippo de Queiroz

; Lopes, Antônio Carlos

; Torres, Albina Rodrigues

; Diniz, Juliana Belo

; Fontenelle, Leonardo F.

; Rosário, Maria Conceição do

; Shavitt, Roseli Gedanke

; Miguel, Eurípedes Constantino

; da Silva, Renata de Melo Felipe

; Costa, Daniel Lucas da Conceição

Brazilian Journal of Psychiatry

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apr 2023, Volume 45 N. 2 Pages 146 - 161

Abstract: En | Text: En | PDF: En

Objectives: To summarize evidence-based pharmacological treatments and provide guidance on clinical interventions for adult patients with obsessive-compulsive disorder (OCD). Methods: The American Psychiatric Association (APA) guidelines for the treatment of OCD (2013) were updated with a systematic review assessing the efficacy of pharmacological treatments for adult OCD, comprising monotherapy with selective serotonin reuptake inhibitors (SSRIs), clomipramine, serotonin and norepinephrine reuptake inhibitors (SNRIs), and augmentation strategies with clomipramine, antipsychotics, and glutamate-modulating agents. We searched for the literature published from 2013-2020 in five databases, considering the design of the study, primary outcome measures, types of publication, and language. Selected articles had their quality assessed with validated tools. Treatment recommendations were classified according to levels of evidence developed by the American College of Cardiology and the American Heart Association (ACC/AHA). Results: We examined 57 new studies to update the 2013 APA guidelines. High-quality evidence supports SSRIs for first-line pharmacological treatment of OCD. Moreover, augmentation of SSRIs with antipsychotics (risperidone, aripiprazole) is the most evidence-based pharmacological intervention for SSRI-resistant OCD. Conclusion: SSRIs, in the highest recommended or tolerable doses for 8-12 weeks, remain the first-line treatment for adult OCD. Optimal augmentation strategies for SSRI-resistant OCD include low doses of risperidone or aripiprazole. Pharmacological treatments considered ineffective or potentially harmful, such as monotherapy with antipsychotics or augmentation with ketamine, lamotrigine, or N-acetylcysteine, have also been detailed.

https://doi.org/10.47626/1516-4446-2022-2891

Predictors of gaming disorder in children and adolescents: a school-based study
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Ferreira, Felipe de M.

; Bambini, Beatriz B.

; Tonsig, Gabriela K.

; Fonseca, Lais

; Picon, Felipe A.

; Pan, Pedro M.

; Salum, Giovanni A.

; Jackowski, Andrea

; Miguel, Eurípedes C.

; Rohde, Luis A.

; Bressan, Rodrigo A.

; Gadelha, Ary

Brazilian Journal of Psychiatry

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jun 2021, Volume 43 N. 3 Pages 289 - 292

Abstract: En | Text: En | PDF: En

Objective: To determine whether psychiatric and gaming pattern variables are associated with gaming disorder in a school-based sample. Methods: We analyzed data from the Brazilian High-Risk Cohort for Psychiatric Disorders, a community sample aged 10 to 18, using questionnaires on gaming use patterns. We applied the Gaming Addiction Scale to diagnose gaming disorder and the Development and Well-Being Behavior Assessment for other diagnoses. Results: Out of 407 subjects, 83 (20.4%) fulfilled the criteria for gaming disorder. More role-playing game players were diagnosed with gaming disorder that any other genre. Gaming disorder rates increased proportionally to the number of genres played. Playing online, being diagnosed with a mental disorder, and more hours of non-stop gaming were associated with higher rates of gaming disorder. When all variables (including age and gender) were considered in a logistic regression model, the number of genres played, the number of non-stop hours, the proportion of online games, and having a diagnosed mental disorder emerged as significant predictors of gaming disorder. Conclusion: Each variable seems to add further risk of gaming disorder among children and adolescents. Monitoring the length of gaming sessions, the number and type of genres played, time spent gaming online, and behavior changes may help parents or guardians identify unhealthy patterns of gaming behavior.

https://doi.org/10.1590/1516-4446-2020-0964 336 downloads

COMVC-19: A Program to protect healthcare workers’ mental health during the COVID-19 Pandemic. What we have learned
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Fukuti, Pedro

; Uchôa, Caroline Louise Mesquita

; Mazzoco, Marina Flaborea

; Cruz, Isabella D'Andrea Garcia da

; Echegaray, Mariana V.F.

; Humes, Eduardo de Castro

; Silveira, Júlia Belizário

; Santi, Talita Di

; Miguel, Euripedes Constantino

; Corchs, Felipe

; Fatori, Daniel

; Campello, Guilherme

; Oliveira, Gabriel M. de

; Argolo, Felipe C.

; Ferreira, Felipe de M.

; Machado, Gustavo

; Argeu, Adriana

; Oliveira, Graça Maria Ramos de

; Serafim, Antônio de Pádua

; Siqueira, Luciana de Lima

; Rossi, Luciane de

; Rios, Izabel Cristina

; Oliveira, Talita Rodrigues de

; Antoniazzi, Leilane C. K.

; Gagliotti, Daniel Augusto Mori

; Abelama Neto, Emílio

; Oliveira Junior, Paulo Novais de

; Correia, Aline Villalobo

; Gonçalves, Luca Schilling

; Tortato, Liana Silva

; Busato, Wagner Machado Moraes

; Guimarães-Fernandes, Flávio

; Alves, Marcos

; Leite Netto, Oswaldo Ferreira

; Schoueri, Patrícia de Campos Lindenberg

; Roque, Márcio de Assis

; Merlin, Silvia Stahl

; Boer, Giovana Cardoso Machado

; Sallet, Paulo Clemente

; Malbergier, André

; Spedo, Mariana Abrahão

; Kamitsuji, Carla Satie

; Faria, Elizabeth de

; Moreira, Moacyr Vergara de Godoy

; Kaufman, Arthur

; Abdo, Carmita

; Scanavino, Marco de Tubino

; Lancman, Selma

; Tavares, Hermano

; Polanczyk, Guilherme

; Brunoni, André R.

; Forlenza, Orestes V.

; Barros-Filho, Tarcísio Eloy Pessoa de

Clinics

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2021, Volume 76 elocation e2631

Abstract: En | Text: En | PDF: En

OBJECTIVE: In 2020, the COVID-19 pandemic brought a work and stress overload to healthcare workers, increasing their vulnerability to mental health impairments. In response, the authors created the COMVC-19 program. The program offered preventive actions and mental health treatment for the 22,000 workers of The Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP). This paper aims to describe its implementation and share what we have learned from this experience. METHODS: Workers were able to easily access the program through a 24/7 hotline. Additionally, a mobile phone app that screened for signs and symptoms of emotional distress and offered psychoeducation and/or referral to treatment was made available. Data from both these sources as well as any subsequent psychiatric evaluations were collected. RESULTS: The first 20 weeks of our project revealed that most participants were female, and part of the nursing staff working directly with COVID-19 patients. The most frequently reported symptoms were: anxiety, depression and sleep disturbances. The most common diagnoses were Adjustment, Anxiety, and Mood disorders. CONCLUSIONS: Implementing a mental health program in a multimodal intervention was feasible in a major quaternary public hospital. Our data also suggests that preventive actions should primarily be aimed at anxiety and depression symptoms, with a particular focus on the nursing staff.

https://doi.org/10.6061/clinics/2021/e2631

Anti-Ri autoimmune encephalitis associated with breast cancer AntiRi Anti Ri
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CARVALHO NETO, Euripedes Gomes de

; GOMES, Matheus Ferreira

; ALVES, Ronnie Peterson Marcondes

; SANTOS, Alexei Peter dos

; BRUM, Cristiano

; SANTIN, Ricardo

Arquivos de Neuro-Psiquiatria

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nov 2020, Volume 78 N. 11 Pages 737 - 737

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/0004-282x20200091

Synergic effect of simvastatin in combination with amphotericin B against environmental strains of Cryptococcus neoformans from northeastern Brazil: a prospective experimental study
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Silva, Tássio Henrique Sousa

; Araújo, Claudiane Vansoski

; Santos, Khelvin Myner da Costa

; Alves, Nathanael dos Santos

; Gomes, Thayse Haylene Soares

; Silva, Andressa Kelly Ferreira e

; Silva, Nayra Cristina Lira dos Santos

; Damasceno Júnior, Evandro César Bezerra

; Carvalho, Andressa Maria Aguiar de

; Mendes, Maria Gabriela Araújo

; Caminha, Henrique Barros

; Daboit, Tatiane Caroline

; Ferreira, Thatiana Bragine

; Andrade-Silva, Leonardo Eurípedes

; Silva-Vergara, Mario León

; Ferreira-Paim, Kennio

; Fonseca, Fernanda Machado

Sao Paulo Medical Journal

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feb 2020, Volume 138 N. 1 Pages 40 - 46

Abstract: En | Text: En | PDF: En

BACKGROUND: Statins are used as cholesterol-lowering drugs and may also have direct antimicrobial effects. OBJECTIVE: To evaluate synergic interactions between simvastatin and both amphotericin B and fluconazole, against environmental strains of Cryptococcus neoformans isolated from captive birds’ droppings. DESIGNAND SETTING: Experimental study conducted at Federal University of Piauí, Parnaíba, in collaboration with Federal University of Triângulo Mineiro, Uberaba, Brazil. METHODS: Statin susceptibility tests of Cryptococcus neoformans samples were performed as prescribed in standards. Interactions of simvastatin with amphotericin and fluconazole were evaluated using the checkerboard microdilution method. Presence of these interactions was quantitatively detected through determining the fractional inhibitory concentration index (FICI). RESULTS: Isolates of Cryptococcus neoformans were obtained from 30 of the 206 samples of dry bird excreta (14.5%) that were collected from pet shops and houses. Ten isolates were selected for susceptibility tests. All of them were susceptible to amphotericin and fluconazole. All presented minimum inhibitory concentration (MIC) > 128 µg/ml and, thus, were resistant in vitro to simvastatin. An in vitro synergic effect was shown through combined testing of amphotericin B and simvastatin, such that six isolates (60%) presented FICI < 0.500. Two isolates showed considerable reductions in MIC, from 1 µg/ml to 0.250 µg/ml. No synergic effect was observed through combining fluconazole and simvastatin. CONCLUSION: These results demonstrate that simvastatin should be considered to be a therapeutic alternative, capable of potentiating the action of amphotericin B. However, further studies are necessary to clarify the real effect of simvastatin as an antifungal agent.

https://doi.org/10.1590/1516-3180.2019.0107.r2.16092019 584 downloads

Non-ketotic hyperosmolar hyperglycemic chorea
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Gomes, Matheus Ferreira

; Carvalho Neto, Euripedes Gomes de

; Kowacs, Fernando

; Rieder, Carlos R. M.

Revista da Associação Médica Brasileira

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feb 2019, Volume 65 N. 2 Pages 127 - 129

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/1806-9282.65.2.127 1499 downloads

Physiological and sensorial quality of Arabica coffee subjected to different temperatures and drying airflows
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Alves, Guilherme Euripedes

; Borém, Flávio Meira

; Isquierdo, Eder Pedroza

; Siqueira, Valdiney Cambuy

; Cirillo, Marcelo Ângelo

; Pinto, Afonso Celso Ferreira

Acta Scientiarum. Agronomy

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jun 2017, Volume 39 N. 2 Pages 225 - 233

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO. Este trabalho foi realizado com o objetivo de avaliar a correlação entre um grupo de variáveis fisiológicas (condutividade elétrica, lixiviação de potássio e porcentagem de germinação) e um grupo de variáveis de cinética de secagem (tempo e taxa de secagem), bem como verificar a relação entre as variáveis de cinética de secagem e a qualidade sensorial do café, em função do tipo de processamento, da temperatura e do fluxo de ar de secagem. A secagem do café foi realizada em secador de leito fixo com duas temperaturas e dois fluxos de ar. Após a secagem, foi avaliada a qualidade fisiológica e sensorial. A partir dos resultados obtidos, conclui-se que: o café processado via seca é mais sensível à secagem mecânica com ar aquecido do que o processado via úmida, apresentando pior desempenho fisiológico; o fluxo de ar não interfere na qualidade fisiológica do café despolpado e natural; a elevação da temperatura de 40 para 45°C resultou em queda da qualidade fisiológica apenas para o café despolpado e a elevação da taxa de secagem, por meio da elevação do fluxo de ar de secagem, para a temperatura de 40°C teve efeito negativo na qualidade sensorial do café despolpado.

ABSTRACT. The objective of this study was to evaluate the correlation between a group of physiological variables (electrical conductivity, potassium leaching, and germination percentage) and a group of drying kinetics variables (drying time and drying rate) in addition to verifying the relation between drying kinetics variables and coffee quality as a function of processing type, temperature, and drying airflow. Coffee drying was conducted in a fixed-layer dryer at two temperatures and two airflows. After drying, an evaluation of the physiological and sensorial quality was conducted. Based on the results obtained, the following conclusions were drawn: coffee that is processed via a dry method is more sensitive to mechanical drying with heated air than coffee processed via a wet method, resulting in poor physiological performance; airflow does not interfere with the physiological quality of pulped and natural coffees; a temperature increase from 40 to 45°C resulted in a decrease in the physiological quality only for pulped coffee; and an increase in the drying rate as a result of an increase in the drying temperature to 40°C had a negative effect on the sensorial quality of pulped coffee.

https://doi.org/10.4025/actasciagron.v39i2.31065 2131 downloads

Influence of the use of testosterone associated with physical training on some hematologic and physical parameters in older rats with alloxan-induced diabetes
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Silva, Romeu Paulo Martins

; Santos, Rodrigo Otávio dos

; Matildes Junior, Nelson Eurípedes

; Mundim, Antônio Vicente

; Garrote-Filho, Mario da Silva

; Rodrigues, Pâmella Ferreira

; Penha-Silva, Nilson

Archives of Endocrinology and Metabolism

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feb 2017, Volume 61 N. 1 Pages 62 - 69

Abstract: En | Text: En | PDF: En

ABSTRACT Objective This study investigated the possible blood changes in wistar rats elderly with and without treatment with anabolic steroids submitted physical training. Materials and methods Elderly rats (32) were divided into four groups: normal (N), treated normal (NT), diabetic (D) and treated diabetic (DT). They were submitted to 20 sessions of swimming with overload (5% body weight), 40 min/day for four weeks. The NT and DT groups received application of testosterone twice a week. At the end of the sessions, the animals were subjected to swimming until exhaustion and then killed for removal of blood and visceral fat. We evaluated maximum swim time, weight of visceral fat, erythrogram, leukogram, lipidogram and serum levels of glucose, lactate, aspartate aminotransferase and creatine kinase. The results were compared using one-way ANOVA followed by the post hoc Tukey test. Results In elderly diabetic rats, the use of anabolic associated with physical training in older rats resulted in improvement in erythrogram, lipidogram and physical performance for high-intensity aerobic exercise. However, it was related to changes in leukocyte count, probably associated with inflammation. Conclusion The combination of the use of testosterone with physical training, followed by maximal effort test caused changes hematological and biochemical can be associated with improvement in physiological characteristics, with increase of the swimming time and decrease of visceral fat levels, improvement in aerobic metabolism of fatty acids and glucose in normal and diabetic animals.

https://doi.org/10.1590/2359-3997000000200 1307 downloads

10.

Rastreamento do Transtorno de Despersonalização/Desrealização em Estudantes de Medicina de uma Universidade Federal no Brasil
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Silva, Felipe Vencato da

; Carvalho Neto, Eurípedes Gomes de

; Chaves Junior, Lauditoni Pereira

; Jesus, Dkaion Vilela de

; Dantas, Milton Vilar Ferreira

; Fonseca, Allex Jardim da

Revista Brasileira de Educação Médica

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sep 2016, Volume 40 N. 3 Pages 337 - 343

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo Avaliar a prevalência de Transtorno de Despersonalização/Desrealização (DP/DR) em estudantes de Medicina da Universidade Federal de Roraima e correlacionar com dados socioeconômicos e pessoais. Métodos Estudo de corte transversal, quantitativo e descritivo, desenhado para avaliar a prevalência de DP/DR em estudantes de Medicina da Universidade Federal de Roraima (UFRR) em 2014 utilizando-se a Cambridge Depersonalization Scale como instrumento de pesquisa. Resultados A prevalência geral de DP/DR em estudantes de Medicina da UFRR foi de 11,5%. A prevalência foi maior nas séries iniciais (do primeiro ao terceiro ano) (OR = 10,7) em relação às séries finais. Não houve correlação de prevalência de DP/DR com fatores individuais, como idade, sexo ou renda. Conclusão Observamos uma prevalência expressiva de transtorno de DP/DR em acadêmicos de Medicina, que pode afetar negativamente a vida pessoal e profissional, gerando sofrimento significativo. É possível que as séries iniciais apresentem um risco maior de desenvolvimento do transtorno, e os mecanismos de enfrentamento do estresse desenvolvidos pelos estudantes podem exercer papel fundamental na suscetibilidade a este e a outros transtornos psíquicos.

ABSTRACT Objective To assess the prevalence of depersonalization/derealization disorder (DP/DR) among medical students at the Federal University of Roraima and to correlate this with socio-economic and personal variables. Methods A cross-sectional study that is both quantitative and descriptive and designed to assess the prevalence of DP/DR disorder among UFRR medical students in 2014 using the Cambridge Depersonalization Scale as a research tool. Results The overall prevalence of DP/DR among UFRR medical students was 11.5%, with the prevalence higher among lower grades (1st to 3rd year) (OR = 10.7) compared to the final series. There was no correlation between the prevalence of DP/DR and individual factors such as age, gender or income. Conclusion We observed a high prevalence of DP/DR disorder among medical students, which may adversely affect their personal and professional life, causing significant distress. It is possible that students in lower years are at a greater risk of developing the disorder, and that mechanisms developed by students used to face stress may play a key role in their susceptibility to this and other psychological disorders.

https://doi.org/10.1590/1981-52712015v40n3e01102015 5337 downloads

11.

Livedo reticular associado com Anemia Hemolítica Autoimune: remissão prolongada induzida pelo Transplante de Células-Tronco do Sangue Periférico com recaída após 10 anos e restauração dos níveis de hemoglobina por rituximabe
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Ferreira, Eurípedes

; Feitosa, Andrezza

; Hamerschlak, Nelson

; Scheinberg, Morton Aaron

Revista Brasileira de Reumatologia

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feb 2012, Volume 52 N. 1 Pages 122 - 124

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

A anemia hemolítica autoimune (AHAI) é uma doença na qual são produzidos anticorpos diretamente contra as glicoproteínas adsorvidas na superfície da membrana dos eritrócitos. Algumas medicações e outras associações têm sido implicadas. Descrevemos e discutimos um caso de livedo reticular associado à AHAI tratado com transplante de células-tronco de sangue periférico (TCTSP) e que entrou em total remissão por 10 anos. Após esse período, a paciente apresentou recaída, foi tratada com anticorpo anti-CD20 (rituximabe), e atualmente encontra-se em total remissão. O papel do TCTSP e o uso de rituximabe no tratamento de AHAI serão discutidos neste relato de caso

Autoimmune hemolytic anemia (AIHA) is a disease where patients produce antibodies against erythrocytes directed towards membrane glycoproteins adsorbed onto the erythrocyte surface. Drugs and other associations have been implicated. It is described and discussed a case of livedo reticularis associated with AIHA treated with peripheral blood stem cell transplantation (PBSCT) that went into full remission for 10 years. After that period the patient relapsed and was treated with antibody anti-CD20, rituximab, and is now in full remission. The role of PBSCT and rituximab in the treatment of AIHA will be discussed

5592 downloads

12.

Autologous stem-cell transplantation for multiple myeloma: a Brazilian institution experience in 15 years of follow-up
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Todaro, Juliana

; Manhani, Ana Rita de Araújo Burgos

; Kutner, José Mauro

; Ribeiro, Andreza Alice Feitosa

; Rodrigues, Morgani

; Kerbauy, Fabio Rodrigues

; Sobrinho, Jairo Nascimento

; Ferreira, Eurípedes

; Hamerschlak, Nelson

einstein (São Paulo)

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jun 2011, Volume 9 N. 2 Pages 119 - 123

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Objetivo: Determinar a sobrevida de pacientes portadores de mieloma múltiplo em 5 anos pós-transplante. Métodos: Estudo retrospectivo em pacientes com diagnóstico de mieloma múltiplo submetidos a transplante autólogo de medula óssea em uma instituição brasileira, no período de 1993 a 2007. Resultados: Foram avaliados 73 pacientes com mediana de idade de 55 anos. A sobrevida encontrada em 5 anos foi de 75% (2,4 a 60 meses). A análise estatística demonstrou significância estatística para o grau de resposta ao tratamento aplicado previamente ao transplante autólogo de medula óssea (p = 0,01). Não houve significância estatística para o estadiamento clínico ou período de diagnóstico (antes ou após o ano 2000). Conclusão: A experiência na realização de transplante autólogo de medula para mileoma múltiplo, em uma instituição brasileira, demonstrou uma evolução concordante com a literatura médica e destacou a importância da resposta prévia ao transplante na sobrevida desses pacientes.

Objective: To determine the 5-year post-transplant survival of patients with multiple myeloma. Methods: A retrospective study in patients diagnosed with multiple myeloma submitted to autologous bone marrow transplantation at a Brazilian institution, during the period of 1993 to 2007. Results: Seventy-three patients were evaluated with a median age of 55 years. Survival in 5 years was 75% (2.4 to 60 months). Statistical analysis demonstrated statistical significance for the applied grade of response prior to treatment with autologous bone marrow transplantation (p = 0.01). There was no statistical significance for clinical staging or time of diagnosis (before or after the year 2000). Conclusion: Experience in autologous bone marrow transplantation for multiple myeloma at a Brazilian institution demonstrated an evolution consistent with that of medical literature and highlighted the importance of a response to treatment prior to transplantation in the survival of these patients.

https://doi.org/10.1590/s1679-45082011ao1845 4933 downloads

13.

Cadmium availability and accumulation by lettuce and rice
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Pereira, Bruno Fernando Faria

; Rozane, Danilo Eduardo

; Araújo, Suzana Romeiro

; Barth, Gabriel

; Queiroz, Rafaela Josemara Barbosa

; Nogueira, Thiago Assis Rodrigues

; Moraes, Milton Ferreira

; Cabral, Cleusa Pereira

; Boaretto, Antonio Enedi

; Malavolta, Eurípedes

Revista Brasileira de Ciência do Solo

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apr 2011, Volume 35 N. 2 Pages 645 - 654

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Entre os elementos tóxicos, o Cd tem recebido atenção considerável por sua associação com diversos problemas de saúde humana. Objetivou-se com este estudo avaliar a disponibilidade de Cd no solo e seu acúmulo, taxa de transferência e toxidez em plantas de arroz e alface cultivadas em Latossolo Vermelho-Amarelo contaminado com esse elemento. Foram realizados dois experimentos simultâneos com a cultura da alface e do arroz. O delineamento adotado foi em blocos ao acaso; em cada experimento, foram avaliadas quatro doses de Cd (CdCl2), com quatro repetições: 0,0, 1,3, 3,0 e 6,0 mg kg-1, definidas com base nos valores orientadores de Cd no solo estabelecidos pela Companhia Ambiental do Estado de São Paulo (Cetesb). As doses de Cd aplicadas no solo aumentaram a concentração desse nutriente nele disponível (Mehlich-3, Mehlich-1 e DTPA) e diminuíram a produção de massa seca das plantas de alface e de arroz. Contudo, não foram observados sintomas de toxidez nas plantas. Os extratores Mehlich-1, Mehlich-3 e DTPA foram eficientes na predição das concentrações de Cd disponível no solo, bem como do teor e acúmulo de Cd nas partes vegetais. Os teores de Cd nos grãos de arroz permaneceram abaixo dos limites máximos estabelecidos para o consumo humano, conforme a legislação brasileira. Entretanto, para a alface, as concentrações de Cd verificadas na parte aérea excederam o limite tolerado.

Among the toxic elements, Cd has received considerable attention in view of its association with a number of human health problems. The objectives of this study were to evaluate the Cd availability and accumulation in soil, transfer rate and toxicity in lettuce and rice plants grown in a Cd-contaminated Typic Hapludox. Two simultaneous greenhouse experiments with lettuce and rice test plants were conducted in a randomized complete block design with four replications. The treatments consisted of four Cd rates (CdCl2), 0.0; 1.3; 3.0 and 6.0 mg kg-1, based on the guidelines recommended by the Environmental Agency of the State of São Paulo, Brazil (Cetesb). Higher Cd rates increased extractable Cd (using Mehlich-3, Mehlich-1 and DTPA chemical extractants) and decreased lettuce and rice dry matter yields. However, no visual toxicity symptoms were observed in plants. Mehlich-1, Mehlich-3 and DTPA extractants were effective in predicting soil Cd availability as well as the Cd concentration and accumulation in plant parts. Cadmium concentration in rice remained below the threshold for human consumption established by Brazilian legislation. On the other hand, lettuce Cd concentration in edible parts exceeded the acceptable limit.

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14.

Transplante de medula óssea com doador familiar parcialmente compatível
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Saboya, Rosaura

; Dulley, Frederico L.

; Ferreira, Euripedes

; Simões, Belinda

Revista Brasileira de Hematologia e Hemoterapia

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may 2010, Volume 32 Suppl. 1 Pages 13 - 15

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O transplante de células-tronco hematopoéticas alogênico (TCTH alo) após um regime de condicionamento ablativo ou não mieloablativo é um tratamento potencialmente curativo para uma grande variedade de doenças malignas hematológicas e outras desordens não hematológicas. O doador HLA aparentado totalmente compatível continua contribuindo para as melhores taxas de sobrevida global e livre de progressão; contudo, apenas 25%-30% dos candidatos a TCTH alo apresentam um doador aparentado HLA (antígenos leucocitários humanos) compatível. A busca por doadores não aparentados cadastrados nos bancos de medula óssea nacional e internacional demanda tempo, que, a depender da situação clínica da doença do paciente e sua deterioração clínica, não permite a espera. Neste sentido, o transplante com doadores familiares parcialmente compatíveis tem se mostrado uma opção terapêutica. Este artigo revisa a literatura e demonstra a factibilidade desta opção.

Myeloablative or non-myeloablative related allogeneic bone marrow transplantation is a curative treatment in some oncologic and hematologic diseases. Unfortunately, only 25 to 30% of patients find a fully matched related donor. National and International donor programs are an option, however, much time is lost and patients can not wait because of their advance disease status or clinical deterioration. Partially matched family donor allogeneic bone marrow transplantation may be an option. This article reviews the literature on this subject.

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The drug-naïve OCD patients imaging genetics, cognitive and treatment response study: methods and sample description
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Hoexter, Marcelo Queiroz

; Shavitt, Roseli Gedanke

; D'Alcante, Carina Chaubet

; Cecconi, Janaina Philippi

; Diniz, Juliana Belo

; Belotto-Silva, Cristina

; Hounie, Ana Gabriela

; Borcato, Sonia

; Moraes, Ivanil

; Joaquim, Marines Alves

; Cappi, Carolina

; Sampaio, Aline Santos

; Mathis, Maria Alice de

; Batistuzzo, Marcelo Camargo

; Lopes, Antonio Carlos

; Rosa, Ana Carolina Ferreira

; Muniz, Renan Kawano

; Marques, Andrea Horvath

; Santos, Luciana Cristina

; Taub, Anita

; Duran, Fábio Luís de Souza

; Dougherty, Darin Dean

; Busatto, Geraldo Filho

; Bressan, Rodrigo Affonseca

; Miguel, Euripedes Constantino

Brazilian Journal of Psychiatry

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dec 2009, Volume 31 N. 4 Pages 349 - 353

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

OBJETIVO: Descrever um protocolo integrativo de investigação neurobiológica para melhor compreender as bases patofisiológicas do transtorno obsessivo-compulsivo e apresentar as características clínicas e demográficas da amostra. MÉTODO: Protocolo padronizado que combina diferentes modalidades de investigação (genética, neuropsicologia, ressonância magnética cerebral e imagem molecular do transportador de dopamina) obtidas antes e depois do tratamento em pacientes com transtorno obsessivo-compulsivo nunca expostos à medicação submetidos a um ensaio clínico comparando um inibidor seletivo da recaptação de serotonina (fluoxetina) e terapia cognitivo-comportamental em grupo. RESULTADOS: Cinquenta e dois pacientes com transtorno obsessivo-compulsivo entraram no ensaio clínico (27 no grupo fluoxetina e 25 no grupo de terapia). No início, foram realizadas 47 coletas de sangue para genética, 50 avaliações neuropsicológicas, 50 ressonâncias magnéticas cerebrais e 48 exames de tomografia computadorizada por emissão de fóton único (SPECT) com TRODAT-1. Depois de 12 semanas, 38 pacientes terminaram o protocolo (20 no grupo de fluoxetina e 18 no grupo de terapia). Trinta e oito reavaliações neuropsicológicas, 31 ressonâncias magnéticas de crânio e 34 exames de SPECT foram obtidos após o tratamento. Quarenta e um controles pareados foram submetidos ao mesmo protocolo inicial. CONCLUSÃO: Os dados genéticos, neuropsicológicos, volumétricos e moleculares do transportador de dopamina aliados à resposta a tratamento podem tanto gerar informações importantes a respeito da neurobiologia do transtorno obsessivo-compulsivo quanto ter uma aplicação clínica.

OBJECTIVE: To describe a protocol that was based on an integrative neurobiological model of scientific investigation to better understand the pathophysiology of obsessive-compulsive disorder and to present the clinical and demographic characteristics of the sample. METHOD: A standardized research protocol that combines different methods of investigation (genetics, neuropsychology, morphometric magnetic resonance imaging and molecular neuroimaging of the dopamine transporter) obtained before and after treatment of drug-naïve adult obsessive-compulsive disorder patients submitted to a sequentially allocated 12-week clinical trial with a selective serotonin reuptake inhibitor (fluoxetine) and group cognitive-behavioral therapy. RESULTS: Fifty-two treatment-naïve obsessive-compulsive disorder patients entered the clinical trial (27 received fluoxetine and 25 received group cognitive-behavioral therapy). At baseline, 47 blood samples for genetic studies, 50 neuropsychological evaluations, 50 morphometrical magnetic resonance images and 48 TRODAT-1 single-photon emission computed tomography (SPECT) exams were obtained. After 12 weeks, 38 patients completed the protocol (fluoxetine = 20 and GCBT = 18). Thirty-eight neuropsychological evaluations, 31 morphometrical magnetic resonance images and 34 TRODAT-1 SPECT exams were obtained post-treatment. Forty-one healthy controls matched for age, gender, socioeconomic status, level of education and laterality were submitted to the same research procedures at baseline. CONCLUSION: The comprehensive treatment response protocol applied in this project allowing integration on genetic, neuropsychological, morphometrical and molecular imaging of the dopamine transporter data in drug-naïve patients has the potential to generate important original information on the neurobiology of obsessive-compulsive disorder, and at the same time be clinically meaningful.

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