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Abstract The present study aims to verify the effect of ozone gas (OZY® System) and high frequency electric pulse (Endox® System) systems on human root canals previously contaminated with Escherichia colilipopolysaccharide (LPS). Fifty single-rooted teeth had their dental crowns removed and root lengths standardized to 16 mm. The root canals were prepared up to #60 hand K-files and sterilized using gamma radiation with cobalt 60. The specimens were divided into the following five groups (n = 10) based on the disinfection protocol used: OZY® System, one 120-second-pulse (OZY 1p); OZY® System, four 24-second-pulses (OZY 4p); and Endox® System (ENDOX). Contaminated and non-contaminated canals were exposed only to apyrogenic water and used as positive (C+) and negative (C-) controls, respectively. LPS (O55:B55) was administered in all root canals except those belonging to group C-. After performing disinfection, LPS samples were collected from the canals using apyrogenic paper tips. Limulus Amoebocyte Lysate (LAL) was used to quantify the LPS levels, and the data obtained was analyzed using one-way ANOVA. The disinfection protocols used were unable to reduce the LPS levels significantly (p = 0.019). The use of ozone gas and high frequency electric pulses was not effective in eliminating LPS from the root canals.

https://doi.org/10.1590/1807-3107BOR-2016.vol30.0019 3012 downloads

Detection of Apical Inflammatory Root Resorption Associated with Periapical Lesion Using Different Methods
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Estrela, Carlos

; Guedes, Orlando Aguirre

; Rabelo, Luiz Eduardo G.

; Decurcio, Daniel Almeida

; Alencar, Ana Helena G

; Estrela, Cyntia R.A.

; Figueiredo, José Antônio Poli de

Brazilian Dental Journal

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oct 2014, Volume 25 N. 5 Pages 404 - 408

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O objetivo deste estudo foi detectar reabsorção radicular inflamatória apical (RRIA) associada à lesão periapical utilizando tomografia computadorizada de feixe cônico (TCFC) e microscopia eletrônica de varredura (MEV). Este estudo clínico avaliou RRIA em 88 ápices radiculares de 52 dentes permanentes de 14 pacientes, extraídos por diferentes motivos. Os pacientes foram submetidos a uma entrevista clínica, revisão da história médica/dental, exames clínicos e de imagem para o plano de tratamento. Todos os dentes selecionados apresentaram condição não restaurável devido à extensa perda de estrutura dental associada a lesões cariosas, e infecção do canal radicular associada a lesões periapicais. TCFC foram obtidas dos pacientes com o objetivo de diagnosticar as alterações periapicais que se mostraram complexas ou duvidosas. Dois examinadores avaliaram a presença ou ausência de RRIA. Os ápices foram também analisados por MEV. O teste do qui-quadrado foi usado para comparar os métodos de detecção de RRIA. O nível de significância foi estabelecido em 5%. RRIA associada à infecção do canal radicular e periodontite apical foi encontrada em 61,4% dos casos estudados usando MEV, e pelo menos metade dos casos utilizando TCFC. A análise microscópica continua a ser o padrão frente a métodos de imagens para a identificação de RRIA.

The aim of this study was to detect apical inflammatory root resorption (AIRR) associated with periapical lesion using cone beam computed tomography (CBCT) and scanning electronic microscopy (SEM). This clinical study evaluated AIRR in 88 root apexes, from 52 permanent teeth of 14 patients, extracted for different reasons. The patients were submitted to a clinical interview, review of dental/medical histories and clinical/imaging examinations for treatment planning. All selected teeth showed unrestorable condition because of the extensive coronal breakdown due to carious lesions, and root canal infection associated with periapical lesions. CBCT images were obtained from the patients with the aim of diagnosing the periapical diseases which showed complex or doubtful conditions. Two examiners assessed the presence or absence of AIRR. Apices were also analyzed under SEM. Chi-square test was used to compare the imaging methods for detection of AIRR. The level of statistical significance was set at 5%. AIRR associated with root canal infection and apical periodontitis was found in 61.4% of the cases studied by using SEM, and at least half of the cases by CBCT. The microscopic analysis remains as a reference standard against the imaging method to identify AIRR.

https://doi.org/10.1590/0103-6440201302432 4452 downloads

Evaluation of hemodynamic effects of xenon in dogs undergoing hemorrhagic shock
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Franceschi, Ruben C.

; Malbouisson, Luiz

; Yoshinaga, Eduardo

; Auler Jr., Jose Otavio Costa

; Figueiredo, Luiz Francisco Poli de

; Carmona, Maria Jose C.

Clinics

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2013, Volume 68 N. 2 Pages 231 - 238

Abstract: En | Text: En | PDF: En

OBJECTIVES: The anesthetic gas xenon is reported to preserve hemodynamic stability during general anesthesia. However, the effects of the gas during shock are unclear. The objective of this study was to evaluate the effect of Xe on hemodynamic stability and tissue perfusion in a canine model of hemorrhagic shock. METHOD: Twenty-six dogs, mechanically ventilated with a fraction of inspired oxygen of 21% and anesthetized with etomidate and vecuronium, were randomized into Xenon (Xe; n = 13) or Control (C; n = 13) groups. Following hemodynamic monitoring, a pressure-driven shock was induced to reach an arterial pressure of 40 mmHg. Hemodynamic data and blood samples were collected prior to bleeding, immediately after bleeding and 5, 20 and 40 minutes following shock. The Xe group was treated with 79% Xe diluted in ambient air, inhaled for 20 minutes after shock. RESULT: The mean bleeding volume was 44 mL.kg-1 in the C group and 40 mL.kg-1 in the Xe group. Hemorrhage promoted a decrease in both the cardiac index (p<0.001) and mean arterial pressure (p<0.001). These changes were associated with an increase in lactate levels and worsening of oxygen transport variables in both groups (p<0.05). Inhalation of xenon did not cause further worsening of hemodynamics or tissue perfusion markers. CONCLUSIONS: Xenon did not alter hemodynamic stability or tissue perfusion in an experimentally controlled hemorrhagic shock model. However, further studies are necessary to validate this drug in other contexts.

https://doi.org/10.6061/CLINICS/2013(02)OA18 1671 downloads

Comparação do índice de esforço percebido e consumo de oxigênio em exercício em cicloergômetro entre gestantes e não-gestantes e entre o exercício aquático e terrestre
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Finkelstein, Ilana

; Kanitz, Ana Carolina

; Bgeginski, Roberta

; Figueiredo, Paulo André Poli de

; Alberton, Cristine Lima

; Stein, Ricardo

; Kruel, Luiz Fernando Martins

Revista Brasileira de Medicina do Esporte

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feb 2012, Volume 18 N. 1 Pages 13 - 16

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O objetivo do presente estudo foi comparar o índice de esforço percebido (IEP) e o consumo de oxigênio (VO2) durante o exercício aquático e terrestre, na intensidade do primeiro limiar ventilatório entre gestantes e não-gestantes. Sete gestantes (idade gestacional entre 27ª e 30ª semanas) e sete não-gestantes realizaram dois testes contínuos em cicloergômetro (água e terra) na intensidade do primeiro limiar ventilatório. Durante os testes, os gases respiratórios foram coletados com um analisador de gases portátil KB1-C da marca Aerosport. A frequência cardíaca (FC) foi obtida através de um Polar modelo F1. Os dados foram coletados a cada 20s. O IEP era indicado ao término do exercício através da escala RPE de Borg (6-20). Utilizou-se ANOVA para medidas repetidas de 1 FATOR, com post hoc de Bonferroni (p < 0,05). Não foram encontradas diferenças significativas para o VO2 e para o IEP comparando os exercícios aquático e terrestre. Além disso, não foram encontradas diferenças significativas entre gestantes e não-gestantes. Concluímos que o IEP pode ser usado para prescrição do exercício aquático e terrestre e para gestantes e não-gestantes, quando este for realizado na intensidade do primeiro limiar ventilatório e em cicloergômetro.

The purpose of the present study was to assess the differences in ratings of perceived exertion (RPE) and oxygen uptake (VO2) behavior during water and land-based exercise, performed in the exercise intensity of the first ventilatory threshold between pregnant and non-pregnant women. Seven pregnant (gestational ages between the 27th and 30th week) and seven non-pregnant women performed two continuous cycle ergometer tests (water and land-based) at the first ventilatory threshold intensity. During all sessions, respiratory gases were collected with a portable AEROSPORT KB1-C mixing box gas analyzer. A pneumotach was used with a neoprene mask. Heart rate (HR) measurements were obtained with a POLAR F1. Data were collected every 20s. RPE on Borg scale from 6 to 20 was derived at the end of the exercise. One-way ANOVA was applied for repeated measures using the post-hoc Bonferroni test (p<0.05). No significant differences were found in VO2 or RPE when comparing water with land-based exercise. In the same way, no significant difference was found between pregnant and non-pregnant subjects. We suggest that RPE can be used for water and land-based exercise prescription on cycle ergometer at the intensity of first ventilatory threshold, for both pregnant and non-pregnant women.

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Implementação financeira e o impacto do mutirão de cirurgias de varizes, após a criação do Fundo de Ações Estratégias e Compensação (FAEC)
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Souza, Maira Oliveira

; Miranda Júnior, Fausto

; Figueiredo, Luiz Francisco Poli de

; Pitta, Guilherme Benjamin Brandão

; Aragão, José Aderval

Jornal Vascular Brasileiro

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dec 2011, Volume 10 N. 4 Pages 302 - 307

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

CONTEXTO: Apesar de reconhecer que o número apresentado pelo mutirão de cirurgias eletivas não refletisse inteiramente a realidade, foi significativa a implementação financeira do Ministério da Saúde do Brasil, bem como o aumento de cirurgias de varizes, após criação do Fundo de Ações Estratégias e Compensação (FAEC). OBJETIVO: Avaliar os resultados da aplicação do investimento financeiro do Ministério da Saúde no mutirão de cirurgias de varizes. MÉTODOS:Foi realizado um estudo transversal de natureza retrospectiva, utilizando informações do banco de dados do Departamento de Informática do Sistema Único de Saúde. Foram incluídas na pesquisa todas autorizações de internação hospitalar das cirurgias de varizes de membros inferiores pagas pelo Ministério da Saúde do Brasil, no período de janeiro de 1998 a dezembro de 2004. RESULTADOS: Em 1998, antes da implementação do mutirão de cirurgias eletivas foram realizadas 23.531 cirurgias de varizes e investidos R$ 5.819.033,27. Após a criação do FAEC, foram realizadas 457.026 cirurgias de varizes de membros inferiores, no período de 1999 a 2004, e foram investidos R$ 187.760.196,81 com média de R$ 31.293.336,13 por ano. CONCLUSÃO: O investimento feito pelo Ministério da Saúde durante o programa de mutirões de cirurgias eletivas pelo FAEC, proporcionou aumento significativo do número de cirurgias de varizes em todo Brasil.

BACKGROUND: In spite of the fact that the number of surgeries presented by the elective surgery task force did not entirely reflect the reality, it is possible to declare that the financial implementation of the Brazilian Ministry of Health has been significative, as well as the increasing number of varicose vein surgeries, especially after the creation of the Strategic Actions and Compensation Fund (FAEC). OBJECTIVE: To evaluate the application of financial investment in the Ministry of Health campaign for varicose vein surgery. METHODS: A transversal study of retrospective nature has been conducted, using information available at the Data Processing Department of the National Healthcare System database (DATASUS). All the authorization of hospital internment from the inferior member varicose vein surgeries, financed by the Brazilian Ministry of Health from January 1998 to December 2004, have been included in the research. RESULTS: In 1998, before the implementation of the elective surgery task force, 23,531 varicose vein surgeries have been performed, and R$ 5,819,033.27 invested. After the creation of the FAEC, 457,026 inferior member varicose vein surgeries have been performed from 1999 to 2004, and R$ 187,760,196.81 were invested with an average of R$ 31,293,336.13 per year. CONCLUSION: Thus, it is possible to conclude that the bigger investment from the Brazilian Ministry of Health, represented by the implementation of the elective surgery task forces by the FAEC, has been responsible for increasing the number of varicose vein surgeries all around Brazil.

3481 downloads Cited 2 times in SciELO

Cardiorespiratory responses during and after water exercise in pregnant and non-pregnant women
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Finkelstein, Ilana

; Figueiredo, Paulo André Poli de

; Alberton, Cristine Lima

; Bgeginski, Roberta

; Stein, Ricardo

; Kruel, Luiz Fernando Martins

Revista Brasileira de Ginecologia e Obstetrícia

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dec 2011, Volume 33 N. 12 Pages 388 - 394

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

OBJETIVO: comparar as respostas da pressão arterial e do consumo de oxigênio (VO2) no exercício em bicicleta ergométrica, realizado na terra e na água, por gestantes e não gestantes. MÉTODOS: dez gestantes (entre 27 e 29 semanas) e dez não gestantes realizaram dois testes em cicloergômetro (um na água e um na terra), na frequência cardíaca correspondente ao primeiro limiar ventilatório (O2LV), com duração de 30 minutos cada. A pressão arterial foi aferida a cada cinco minutos durante o exercício e a frequência cardíaca e o VO2 a cada 20 segundos. Foi utilizada a análise de variância two-way e α=0,05 (SPSS 17.0). RESULTADOS: não houve diferença nas respostas cardiovasculares entre gestantes e não gestantes durante o exercício. O Grupo Gestante apresentou valores significativamente mais baixos de pressão arterial sistólica (131,6±8,2; 142,6±11,3 mmHg), diastólica (64,8±5,9; 74,5±5,3 mmHg) e média estimada (87,0±4,1; 97,2±5,7 mmHg), no exercício aquático comparado ao terrestre, respectivamente. O Grupo Não gestante também apresentou valores de pressão arterial sistólica (130,5±8,4; 135,9±8,7 mmHg), diastólica (67,4±5,7; 69,0±10,1 mmHg) e média (88,4±4,8; 91,3±7,8 mmHg) mais baixos no exercício na água do que na terra, respectivamente. Os valores de VO2 absoluto não apresentaram diferenças significativas, durante o exercício entre gestantes e não gestantes, como também nos meios aquáticos e terrestres. Após cinco minutos de repouso pós-exercício, tanto a pressão arterial quanto o VO2 já apresentavam valores semelhantes aos de repouso pré-exercício. CONCLUSÕES: para gestantes entre 27 e 29 semanas de gestação, a escolha pelo exercício aquático realizado na frequência cardíaca correspondente ao O2LV é fisiologicamente adequada. Essas mulheres também apresentam um comportamento de pressão arterial mais baixo na água comparado ao meio terrestre.

PURPOSE: to compare the blood pressure and oxygen consumption (VO2) responses between pregnant and non-pregnant women, during cycle ergometer exercise on land and in water. METHODS: ten pregnant (27 to 29 weeks of gestation) and ten non-pregnant women were enrolled. Two cardiopulmonary tests were performed on a cycle ergometer (water and land) at the heart rate corresponding to VO2, over a period of 30 minutes each. Exercise measurements consisted of recording blood pressure every five minutes, and heart rate and VO2 every 20 seconds. Two-way ANOVA was used and α=0.05 (SPSS 17.0). RESULTS: there was no difference in cardiovascular responses between pregnant and non-pregnant women during the exercise. The Pregnant Group demonstrated significant differences in systolic (131.6±8.2; 142.6±11.3 mmHg), diastolic (64.8±5.9; 74.5±5.3 mmHg), and mean blood pressure (87.0±4.1; 97.2±5.7 mmHg), during water and land exercise, respectively. The Non-pregnant women Group also had a significantly lower systolic (130.5±8.4; 135.9±8.7 mmHg), diastolic (67.4±5.7; 69.0±10.1 mmHg), and mean blood pressure (88.4±4.8; 91.3±7.8 mmHg) during water exercise compared to the land one. There were no significant differences in VO2 values between water and land exercises or between pregnant and non-pregnant women. After the first five-minute recovery period, both blood pressure and VO2 were similar to pre-exercise values. CONCLUSIONS: for pregnant women with 27 to 29 weeks of gestation, water exercise at the heart rate corresponding to VO2 is physiologically appropriate. These women also present a lower blood pressure response to exercise in water than on land.

6356 downloads Cited 1 time in SciELO

Estudo anatômico da veia braquial comum como via de drenagem colateral do membro superior
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Santos, Carlos Adriano Silva dos

; Figueiredo, Luiz Francisco Poli de

; Gusmão, Luiz Carlos Buarque de

; Castro, Aldemar Araújo

; Pitta, Guilherme Benjamin Brandão

; Miranda Jr, Fausto

; Souza, Érica Carla Figueirêdo de

Jornal Vascular Brasileiro

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mar 2011, Volume 10 N. 1 Pages 40 - 43

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

CONTEXTO: Traumatismos ou tromboses que possam evoluir com alterações da drenagem venosa do membro superior, dependendo do território interrompido, podem ter como mecanismo compensatório uma via colateral de drenagem sem que haja prejuízo para o retorno venoso desse membro. A veia braquial comum apresenta-se como uma alternativa plausível e pouco conhecida. OBJETIVO: Descrever a anatomia da veia braquial comum como via de drenagem colateral no membro superior. MÉTODOS: Utilizamos 30 cadáveres do sexo masculino, cujos membros superiores estavam articulados ao tronco, não importando a raça, formolizados e mantidos em conservação com solução de formol a 10%. Utilizamos como critérios de exclusão cadáveres com um dos membros desarticulado ou alterações deformantes em topografia das estruturas estudadas. RESULTADOS: A veia braquial comum esteve presente em 73% (22/30) dos cadáveres estudados, sendo que em 18% (04/22) dos casos drenou para a veia basílica no seguimento proximal do braço e em 82% (18/22), para a veia axilar. CONCLUSÃO: A veia braquial comum está frequentemente presente e, na maior parte das vezes, desemboca na veia axilar.

BACKGROUND: Trauma and thrombosis that can result in changes in the venous drainage of the upper limb, depending on the vascular territory interrupted, may have as a compensatory mechanism a collateral drainage channel that prevents damage to the venous return of that limb. The common brachial vein is a plausible and little known collateral channel for this purpose. OBJECTIVE: To describe the anatomy of the common brachial vein as a collateral drainage channel of the upper limb. METHODS: We have dissected 30 cadavers of people of different races, whose upper limbs were articulated to the trunk and preserved in a 10% formaldehyde solution. The exclusion criteria were disarticulated limbs or deformities in the topography of the studied structures. RESULTS: The common brachial vein was present in 73% (22/30) of the cadavers dissected. The common brachial vein drained into the axillary vein in 82% (18/22) and into the basilic vein in the proximal segment of the upper limb in 18% of the cadavers (04/22). CONCLUSION: The common brachial vein is frequently present, and, in most cases, it drains into the axillary vein.

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Endovascular treatment of peripheral arterial injury with covered stents: an experimental study in pigs
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Belczak, Sergio

; Silva, Erasmo Simião da

; Aun, Ricardo

; Sincos, Igor Rafael

; Belon, Alessandro Rodrigo

; Casella, Ivan Benaduce

; Gornati, Vitor

; Poli de Figueiredo, Luiz Francisco

Clinics

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2011, Volume 66 N. 8 Pages 1425 - 1430

Abstract: En | Text: En | PDF: En

OBJECTIVE: To evaluate the feasibility of using endovascular repair to treat penetrating arterial injuries with covered stents. Feasibility was examined according to the circumferential extent of the injury. INTRODUCTION: Surgical trauma often increases the risk of major morbidity and mortality associated with vascular injury, and endovascular repair has many advantages in such situations. METHODS: Twenty white male domestic pigs weighing 28-38 kg with controlled vascular injuries were divided into four equal groups according to the circumferential extent of their vascular lesion (i.e., no lesion, lesion <50%, lesion >50%, and complete lesion). The left common carotid artery was dissected with proximal and distal control, and this procedure was followed by controlled sectioning of the arterial wall. Local manual compression was applied for 10 min and was followed by endovascular repair with the placement of a 5x50 mm VIABHAN TM covered stent using the femoral approach. We also monitored additional variables, such as the duration of the procedures (the mean was 56.3 ± 19.1 min), ultrasound parameters (e.g., maximum arterial diameter, peak systolic and diastolic velocity, and resistance index), arteriography findings, and fluctuations in vital signs (e.g., cardiac output, arterial pressure, and central venous pressure). RESULTS: The experimental procedure was found to be feasible and reproducible. Repairs were successful in all animals in the control (no lesion) and <50% lesion groups. Success was also achieved in four out of five pigs in the >50% group and in one pig in the complete lesion group. DISCUSSION: The endovascular repair of an arterial injury is possible, but success depends on the circumferential extent of the arterial lesion. The present experimental model, which involved endovascular techniques, highlighted important factors that must be considered in future studies involving similar animals and materials.

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10.

Aspectos fundamentais da experimentação animal - aplicações em cirurgia experimental
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Damy, Sueli Blanes

; Camargo, Roberto Souza

; Chammas, Rober

; Figueiredo, Luiz Francisco Poli de

Revista da Associação Médica Brasileira

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2010, Volume 56 N. 1 Pages 103 - 111

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Com o objetivo de contribuir à pesquisa em cirurgia experimental, este artigo apresenta uma análise dos principais parâmetros exigidos a serem observados pelos comitês internacionais e nacionais de ética e bem-estar animal, cujo cumprimento é pré-requisito para publicação em periódicos arbitrados de circulação internacional. A padronização da genética, do estado sanitário e do ambiente das espécies de animais Mus musculus (camundongos), Rattus norvegicus (ratos), Oryctolagus cuniculus (coelhos) e Sus scropha domesticus (suínos), a observação de condições adequadas no transporte, aclimatação, enriquecimento do ambiente, treinamento de técnicos em experimentação animal, gestão de informação, biossegurança, dieta, anestesia, cuidados pós-operatórios, analgesia e eutanásia, aliados a projetos de pesquisa bem planejados são apresentados como etapas fundamentais para a obtenção de resultados com alto grau de acuidade, alto nível de reprodutibilidade e precisão.

This study aimed to present the general principles for experiments performed on laboratory animals as required by international and national ethical committees on animal welfare. Compliance to these principles is a prerequisite for publication in international journals. Details of genetic, sanitary and environmental standards, transportation, acclimation, environmental enrichment, appropriate education and training of all those involved in handling of live animals, information management strategy, biossecurity, diet, anesthesia, analgesia, postoperative care and euthanasia for Mus musculus (mice), Rattus norvegicus (rat), Oryctolagus cuniculus (rabbit) and Sus scropha domesticus (pig) combined with well planned biomedical research are fundamental to increase the accuracy, reproducibility and precision of the experimental results.

36851 downloads Cited 17 times in SciELO

11.

Pulmonary metastasectomy from soft tissue sarcomas
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Sardenberg, Rodrigo Afonso da Silva

; Figueiredo, Luiz Poli de

; Haddad, Fábio José

; Gross, Jefferson Luiz

; Younes, Riad Naim

Clinics

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2010, Volume 65 N. 9 Pages 871 - 876

Abstract: En | Text: En | PDF: En

INTRODUCTION: Isolated pulmonary metastases from soft tissue sarcomas occur in 20-50% of these(the issue is about metastases, not lung cancer )patients, and 70% of these patients will present disease limited only to the lungs. Surgical resection is well accepted as a standard approach to treat metastases from soft tissue sarcomas isolated in the lungs, and many studies investigating this technique have reported an overall 5-year survival ranging from 30-40%. The most consistent predictor of survival in these patients is complete resection. The aim of the present study was to determine the demographics and clinical treatment-related variables associated with long-term (90-month) overall survival in patients with lung metastases undergoing pulmonary metastasectomy from soft tissue sarcomas. METHODS: We performed a retrospective review of patients admitted in the Thoracic Surgery Department with lung metastases who underwent thoracotomy for resection following treatment of the primary tumor. Data regarding primary tumor features, demographics, treatment, and outcome were collected. RESULTS: One hundred twenty-two thoracotomies and 273 nodules were resected from 77 patients with previously treated soft tissue sarcomas. The median follow-up time of all patients was 36.7 months (range: 10-138 months). The postoperative complication rate was 9.1%, and the 30-day mortality rate was 0%. The 90-month overall survival rate for all patients was 34.7%. Multivariate analysis identified the following independent prognostic factors for overall survival: the number of metastases resected, the disease-free interval, and the number of complete resections. CONCLUSION: These results confirm that lung metastasectomy is a safe and potentially curative procedure for patients with treated primary tumors. A select group of patients can achieve long-term survival after lung resection.

2745 downloads

12.

Mesenteric microcirculatory dysfunctions and translocation of indigenous bacteria in a rat model of strangulated small bowel obstruction
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Zanoni, Fernando Luiz

; Benabou, Simon

; Greco, Karin Vicente

; Moreno, Ana Carolina Ramos

; Cruz, José Walber Miranda Costa

; Filgueira, Fernando Paranaiba

; Martinez, Marina Baquerizo

; Figueiredo, Luiz Francisco Poli de

; Silva, Maurício Rocha e

; Sannomiya, Paulina

Clinics

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2009, Volume 64 N. 9 Pages 911 - 919

Abstract: En | Text: En | PDF: En

PRUPOSE: Bacterial translocation has been shown to occur in critically ill patients after extensive trauma, shock, sepsis, or thermal injury. The present study investigates mesenteric microcirculatory dysfunctions, the bacterial translocation phenomenon, and hemodynamic/metabolic disturbances in a rat model of intestinal obstruction and ischemia. METHODS: Anesthetized (pentobarbital 50 mg/kg, i.p.) male Wistar rats (250-350 g) were submitted to intestinal obstruction or laparotomy without intestinal obstruction (Sham) and were evaluated 24 hours later. Bacterial translocation was assessed by bacterial culture of the mesenteric lymph nodes (MLN), liver, spleen, and blood. Leukocyte-endothelial interactions in the mesenteric microcirculation were assessed by intravital microscopy, and P-selectin and intercellular adhesion molecule (ICAM)-1 expressions were quantified by immunohistochemistry. Hematocrit, blood gases, lactate, glucose, white blood cells, serum urea, creatinine, bilirubin, and hepatic enzymes were measured. RESULTS: About 86% of intestinal obstruction rats presented positive cultures for E. coli in samples of the mesenteric lymph nodes, liver, and spleen, and 57% had positive hemocultures. In comparison to the Sham rats, intestinal obstruction induced neutrophilia and increased the number of rolling (~2-fold), adherent (~5-fold), and migrated leukocytes (~11-fold); this increase was accompanied by an increased expression of P-selectin (~2-fold) and intercellular adhesion molecule-1 (~2-fold) in the mesenteric microcirculation. Intestinal obstruction rats exhibited decreased PaCO2, alkalosis, hyperlactatemia, and hyperglycemia, and increased blood potassium, hepatic enzyme activity, serum urea, creatinine, and bilirubin. A high mortality rate was observed after intestinal obstruction (83% at 72 h vs. 0% in Sham rats). CONCLUSION: Intestinal obstruction and ischemia in rats is a relevant model for the in vivo study of mesenteric microcirculatory dysfunction and the occurrence of bacterial translocation. This model parallels the events implicated in multiple organ dysfunction (MOD) and death.

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13.

Respostas de freqüência cardíaca, consumo de oxigênio e sensação subjetiva ao esforço em um exercício de hidroginástica executado por mulheres em diferentes situações com e sem o equipamento aquafins
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Pinto, Stephanie Santana

; Alberton, Cristine Lima

; Figueiredo, Paulo André Poli de

; Tiggemann, Carlos Leandro

; Kruel, Luiz Fernando Martins

Revista Brasileira de Medicina do Esporte

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aug 2008, Volume 14 N. 4 Pages 357 - 361

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

As aulas de hidroginástica estão cada vez mais diversificadas com o uso de materiais apropriados ao meio aquático. Entretanto, poucos estudos verificaram a influência da utilização de tais materiais nas respostas cardiorrespiratórias. O objetivo foi analisar as respostas de freqüência cardíaca, consumo de oxigênio e sensação subjetiva ao esforço em mulheres durante a execução de um exercício de hidroginástica em diferentes situações com e sem o equipamento resistivo Aquafins®. Onze mulheres realizaram o exercício deslize frontal com a flexão e extensão horizontal de ombros em quatro situações: sem equipamento resistivo (S-FINS), com Aquafins nos membros inferiores (FINS-MIs), com Aquafins nos membros superiores (FINS-MSs) e com Aquafins nos membros superiores e inferiores (FINS-MIs/MSs). Em todas as situações foi verificado a FC, o VO2 e a SSE. Utilizou-se ANOVA para medidas repetidas, com post-hoc de Bonferroni (p < 0,05). A FC foi significativamente mais elevada nas situações FINS-MIs/MSs (159 ± 12bpm) e FINS-MIs (147 ± 18bpm), comparando-as com as demais situações. No entanto, a situação FINS-MIs apresentou FC similar à FINS-MSs (148 ± 16 bpm). Por sua vez, as três situações com o Aquafins foram diferentes da situação S-FINS (131 ± 14bpm). Para o VO2 houve diferença significativa entre a situação FINS-MIs/MSs (22,77 ± 3,58ml.kg-1.min-1), comparando-a com as demais. As situações FINS-MSs (19,67 ± 4,29ml.kg-1.min-1) e FINS-MIs (20,38 ± 3,99ml.kg-1.min-1) apresentaram VO2 significativamente maior que S-FINS (15,18 ± 4,67ml.kg-1.min-1). A SSE foi significativamente maior na situação FINS-MIs/MSs (16 ± 1,55), comparando-a com FINS-MIs (14 ± 0,9) e S-FINS (13 ± 1,29), entretanto, não foi diferente da FINS-MSs (14 ± 1,57). Portanto, a utilização de equipamentos que promovam resistência ao movimento na hidroginástica é indicada para melhorias no sistema cardiorrespiratório.

Aquatic exercise sessions are becoming increasingly diversified due to the use of apparatus appropriate to aquatic environment. However, few studies analyzed the influence of the use of such apparatus in the cardiorespiratory responses. The purpose was to analyze the heart rate, oxygen consumption and the rating of perceived exertion of effort in women during an aquatic exercise performed in different situations with and without resistive equipment, AquafinsTM. Eleven women performed the cross country skiing exercise with horizontal shoulder flexion and extension in four situations: without resistive equipment (NO-FINS), with Aquafins on the lower limbs (FINS-LLs), with Aquafins on the upper limbs (FINS-ULs) and with Aquafins on the lower and upper limbs (FINS-LLs/ULs). In each situation HR, VO2 and SSE were verified. For data analysis, ANOVA for repeated measures were used, with the Bonferroni post-hoc test (p < 0.05). When compared to the other situations, HR was significantly higher with the FINS-LLs/ULs (159 ± 12 bpm) and FINS-LLs (147 ± 18 bpm). However, the FINS-LLs situation exhibited a similar HR to that of FINS-ULs (148 ± 16 bpm). In turn, the three situations with Aquafins were different from the NO-FINS (131 ± 14 bpm) situation. In the case of VO2, there was a significant difference between the FINS-LLs/ULs (22.77 ± 3.58 ml.kg-1.min-1) situation and the other situations. The FINS-ULs (19.67 ± 4.29 ml.kg-1.min-1) and FINS-LLs (20.38 ± 3.99 ml.kg-1.min-1) situations exhibited significantly higher VO2 levels than NO-FINS (15.18 ± 4.67 ml.kg-1.min-1). The RPE was significantly greater in the FINS-LLs/ULs (16 ± 1.55) situation when compared to FINS-LLs (14 ± 0.9) and NO-FINS (13±1.29), though there was no difference from the FINS-ULs (14 ± 1.57) situation. Therefore, the use of equipments that promote resistence to the movement in aquatic exercise is recommended to improvement in the cardiorespiratory system.

5855 downloads Cited 2 times in SciELO

14.

Sepsis: from bench to bedside
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Silva, Eliézer

; Passos, Rogério Da Hora

; Ferri, Maurício Beller

; Figueiredo, Luiz Francisco Poli de

Clinics

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2008, Volume 63 N. 1 Pages 110 - 120

Abstract: En | Text: En | PDF: En

Sepsis is a syndrome related to severe infections. It is defined as the systemic host response to microorganisms in previously sterile tissues and is characterized by end-organ dysfunction away from the primary site of infection. The normal host response to infection is complex and aims to identify and control pathogen invasion, as well as to start immediate tissue repair. Both the cellular and humoral immune systems are activated, giving rise to both anti-inflammatory and proinflammatory responses. The chain of events that leads to sepsis is derived from the exacerbation of these mechanisms, promoting massive liberation of mediators and the progression of multiple organ dysfunction. Despite increasing knowledge about the pathophysiological pathways and processes involved in sepsis, morbidity and mortality remain unacceptably high. A large number of immunomodulatory agents have been studied in experimental and clinical settings in an attempt to find an efficacious anti-inflammatory drug that reduces mortality. Even though preclinical results had been promising, the vast majority of these trials actually showed little success in reducing the overwhelmingly high mortality rate of septic shock patients as compared with that of other critically ill intensive care unit patients. Clinical management usually begins with prompt recognition, determination of the probable infection site, early administration of antibiotics, and resuscitation protocols based on "early-goal" directed therapy. In this review, we address the research efforts that have been targeting risk factor identification, including genetics, pathophysiological mechanisms and strategies to recognize and treat these patients as early as possible.

5099 downloads Cited 6 times in SciELO

15.

Válvulas da veia braquial comum: estudo anatômico
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Santos, Carlos Adriano Silva dos

; Figueiredo, Luiz Francisco Poli de

; Gusmão, Luiz Carlos Buarque de

; Pitta, Guilherme Benjamin Brandão

; Miranda Jr., Fausto

Jornal Vascular Brasileiro

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mar 2007, Volume 6 N. 1 Pages 35 - 41

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

CONTEXTO: Boa parte das insuficiências venosas é devida à incompetência de suas válvulas. Como uma das alternativas cirúrgicas, temos os enxertos venosos valvulados no segmento insuficiente. OBJETIVO: Descrever a anatomia das válvulas da veia braquial comum. MÉTODOS: Foram selecionados 30 cadáveres do sexo masculino, independentemente de raça, que tinham seus membros superiores articulados ao tronco. Os mesmos estavam formolizados e foram mantidos em conservação com solução de formol a 10%. Utilizamos como critério de exclusão a existência de desarticulação de um dos membros ou de alterações deformantes em topografia das estruturas estudadas. RESULTADOS: O número total de válvulas identificadas foi de 28 em membro superior direito e de 33 em membro superior esquerdo, sendo 15 no segmento proximal direito e 21 no segmento proximal esquerdo. Mais de 91% das válvulas foram do tipo bicúspide e parietal. CONCLUSÃO: Conclui-se que a veia braquial comum apresenta freqüentemente válvulas do tipo bicúspide e parietal.

BACKGROUND: A great part of venous insufficiencies is due to valve incompetence. Valved venous grafts in the insufficient segment are a surgical alternative. OBJECTIVE: To describe the anatomy of the common brachial vein valves. METHODS: We used 30 male corpses of varied races with their upper limbs articulated to the trunk. They were preserved in formol and fixed in a 10% formol solution. Exclusion criteria were presence of disarticulation in one limb or deforming alterations in the topography of assessed structures. RESULTS: The total number of identified valves was 28 in the right arm and 33 in the left arm, 15 of them in the right proximal segment and 21 in the left proximal segment. More than 91% of the valves were bicuspid and parietal. CONCLUSION: We conclude that the common brachial vein often presents bicuspid and parietal valves.

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