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Validation HPLC-DAD Method for Quantification of Gallic and Ellagic Acid from Eugenia punicifolia Leaves, Extracts and Fractions
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Silva, Liliane S.

; Oliveira, Matheus G. de

; Martins, Christiane F.

; Borges, Leonardo L.

; Fiuza, Tatiana S.

; Conceição, Edemilson C. da

; Paula, José R. de

Journal of the Brazilian Chemical Society

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mar 2023, Volume 34 N. 3 Pages 401 - 413

Abstract: En | Text: En | PDF: En

Eugenia punicifolia (Kunth) DC, known as “pedra ume-caá” or “pitanguinha do cerrado”, is popularly used to treat infectious diseases like inflammation, and diabetes. Therefore, this study aimed to develop and validate an analytical method by high-performance liquid chromatography with diode array detector (HPLC-DAD) for the seasonal quantification of gallic acid (GA) and ellagic acid (EA), and to co-validate the method for quantification from the ethanol extract and fractions of the E. punicifolia leaves. Chromatographic separations were performed with a mobile phase gradient of acetonitrile/methanol/water acidified with 0.2% formic acid, a flow of 0.8 mL min 1, detection at 254 nm, and a C18 column (250 × 4.6 mm, 5 µm). Method validation parameters were determined following Brazilian legislation. The HPLC-DAD analytical method developed for the quantification of GA and EA was validated and demonstrated to be selective, linear, precise, accurate, robust, and without matrix effect. Accordingly, it is helpful for the analysis of these tannins in crude ethanol extracts and fractions from E. punicifoila leaves. Thus, our results may be of great help for quality control assessment and standardization of raw materials containing Eugenia punicifolia.

https://doi.org/10.21577/0103-5053.20220117

Knowledge regarding extracorporeal membrane oxygenation management among Brazilian pediatric intensivists: a cross-sectional survey
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Colleti Júnior, José

; Prata-Barbosa, Arnaldo

; Araujo, Orlei Ribeiro

; Tonial, Cristian Tedesco

; Oliveira, Felipe Rezende Caino de

; Souza, Daniela Carla de

; Lima-Setta, Fernanda

; Oliveira, Thiago Silveira Jannuzzi de

; Mello, Mary Lucy Ferraz Maia Fiuza de

; Amoretti, Carolina

; João, Paulo Ramos David

; Neves, Cinara Carneiro

; Oliveira, Norma Suely

; Costa, Cira Ferreira Antunes

; Garros, Daniel

Critical Care Science

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jan 2023, Volume 35 N. 1 Pages 57 - 65

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT Objective: To assess Brazilian pediatric intensivists’ general knowledge of extracorporeal membrane oxygenation, including evidence for its use, the national funding model, indications, and complications. Methods: This was a multicenter cross-sectional survey including 45 Brazilian pediatric intensive care units. A convenience sample of 654 intensivists was surveyed regarding their knowledge on managing patients on extracorporeal membrane oxygenation, its indications, complications, funding, and literature evidence. Results: The survey addressed questions regarding the knowledge and experience of pediatric intensivists with extracorporeal membrane oxygenation, including two clinical cases and 6 optional questions about the management of patients on extracorporeal membrane oxygenation. Of the 45 invited centers, 42 (91%) participated in the study, and 412 of 654 (63%) pediatric intensivists responded to the survey. Most pediatric intensive care units were from the Southeast region of Brazil (59.5%), and private/for-profit hospitals represented 28.6% of the participating centers. The average age of respondents was 41.4 (standard deviation 9.1) years, and the majority (77%) were women. Only 12.4% of respondents had taken an extracorporeal membrane oxygenation course. Only 19% of surveyed hospitals have an extracorporeal membrane oxygenation program, and only 27% of intensivists reported having already managed patients on extracorporeal membrane oxygenation. Specific extracorporeal membrane oxygenation management questions were responded to by only 64 physicians (15.5%), who had a fair/good correct response rate (median 63.4%; range 32.8% to 91.9%). Conclusion: Most Brazilian pediatric intensivists demonstrated limited knowledge regarding extracorporeal membrane oxygenation, including its indications and complications. Extracorporeal membrane oxygenation is not yet widely available in Brazil, with few intensivists prepared to manage patients on extracorporeal membrane oxygenation and even fewer intensivists recognizing when to refer patients to extracorporeal membrane oxygenation centers.

RESUMO Objetivo: Avaliar os conhecimentos gerais dos intensivistas pediátricos brasileiros sobre oxigenação por membrana extracorpórea, incluindo evidências de uso, modelo de custeio nacional, indicações e complicações. Métodos: Este estudo foi um inquérito transversal multicêntrico que incluiu 45 unidades de terapia intensiva pediátrica brasileiras. Realizou-se inquérito de conveniência com 654 intensivistas quanto aos seus conhecimentos sobre manejo de pacientes em oxigenação por membrana extracorpórea, suas indicações, complicações, custeio e evidências bibliográficas. Resultados: O inquérito abordou questões relativas aos conhecimentos e à experiência dos intensivistas pediátricos sobre oxigenação por membrana extracorpórea, incluindo dois casos clínicos e seis questões facultativas sobre o manejo de pacientes em oxigenação por membrana extracorpórea. Dos 45 centros convidados, 42 (91%) participaram do estudo, e 412 (63%) dos 654 intensivistas pediátricos responderam ao inquérito. A maioria das unidades de terapia intensiva pediátrica eram da Região Sudeste do Brasil (59,5%), e os hospitais privados com fins lucrativos representavam 28,6% dos centros participantes. A média de idade dos respondentes era de 41,4 (desvio-padrão de 9,1) anos, e a maioria (77%) era mulher. Apenas 12,4% dos respondentes tinham formação em oxigenação por membrana extracorpórea. Dos hospitais pesquisados, apenas 19% tinham um programa de oxigenação por membrana extracorpórea, e apenas 27% dos intensivistas declararam já ter manejado pacientes em oxigenação por membrana extracorpórea. Apenas 64 médicos (15,5%) responderam a questões específicas sobre o manejo de oxigenação por membrana extracorpórea (mediana 63,4%; oscilando entre 32,8% e 91,9%). Conclusão: A maioria dos intensivistas pediátricos brasileiros demonstrou conhecimentos limitados de oxigenação por membrana extracorpórea, incluindo suas indicações e complicações. A oxigenação por membrana extracorpórea ainda não está amplamente disponível no Brasil, com poucos intensivistas preparados para o manejo de pacientes em oxigenação por membrana extracorpórea e ainda menos intensivistas capazes de reconhecer quando devem encaminhar pacientes para centros de oxigenação por membrana extracorpórea.

https://doi.org/10.5935/2965-2774.20230350-en

Palipocus: The Use of POCUS in the Palliative Gare Setting
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Sousa, Inês Egídio de

; Monteiro, Margarida

; Valente, Tiago

; Santos, André

; Fiuza, Tiago

; Mendes, Adriano Pacheco

; Soares, Rita

; Teixeira, Jorge

; Mariz, José

Medicina Interna

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jun 2022, Volume 29 N. 2 Pages 65 - 73

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Palliative care is the holistic care of individuais with serious health-related suffering due to severe illness. The improving survival in malignant and non-malignant diseases results in an ageing population who tive with advanced chronic diseases that commonly present to acute care settings. With our improved ability to relief symptoms and treat intercurrent complications, imaging can be an important aspect of modem palliative care. Point-of-care ultrasound (POCUS) is ultrasound used at the bedside to answer directed clinical questions and guide clinical care. The goals of our review are to provide greater understanding about utility and appropriateness of the use of POCUS in palliative care. The use of POCUS in the clinical setting has increased substantially in recent years, and its characteristics make it an attractive diagnostic and therapeutic adjunct in palliative care, namely in home-based care.

Resumo Os cuidados paliativas são cuidados holísticos prestados a indivíduos com sofrimento intenso decorrente de doença grave. A melhoria da sobrevida nas doenças malignas e não malignas levou ao envelhecimento da população, que vive com doenças crónicas avançadas e frequentemente recorre aos serviços de saúde. Os métodos imagiológicos não invasivos podem ter um papel importante nos cuidados paliativas modernos, no controlo sintomático e na abordagem de intercorrências agudas. A ecografiapoint-of-care (POCUS) trata-se da ecografia realizada à cabeceira do doente, para responder a questões clínicas dirigidas, com o objetivo de orientar a abordagem clínica. O objetivo da nossa revisão é contribuir para uma maior compreensão acerca da utilidade e adequação de POCUS em cuidados paliativas. A utilização do POCUS na prática clínica tem vindo a aumentar nos últimos anos e as suas características tornam-no uma ferramenta útil no diagnóstico e terapêutica em cuidados paliativas, nomeadamente em equipas de apoio comunitário.

https://doi.org/10.24950/rspmi.651 19 downloads

Aggregation and spatio-temporal dynamics of fruit flies (Diptera, Tephritidae) in papaya orchards associated with different area delimitations in Brazil
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Araujo, Mayara Ribeiro de

; Martins, David dos Santos

; Fornazier, Maurício José

; Uramoto, Keiko

; Ferreira, Paulo Sérgio Fiuza

; Zucchi, Roberto Antonio

; Godoy, Wesley Augusto Conde

Acta Scientiarum. Agronomy

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2022, Volume 44 elocation e53466

Abstract: En | Text: En | PDF: En

ABSTRACT. We investigated aggregation patterns in three fruit fly species economically important in Brazil, namely Ceratitis capitata, Anastrepha fraterculus, and A. obliqua. The study was carried out in a buffer zone and two neighbourhoods by comparing two-time series associated with the management strategy of fruit flies (systems approach). The abundance of these three species significantly decreased over the years with a negative binomial regression model describing the relationship between abundance and time in the entire area, buffer zone, and their neighbourhoods. In addition, the negative binomial model was also well fitted to the frequency distribution data of fruit flies in all analyzed scenarios. Anastrepha obliqua showed the highest aggregation degree, considering both the entire area and time series. A. fraterculus exhibited the lowest aggregation level, and C. capitata showed an intermediate degree. The buffer zone exhibited the highest aggregation degree for all species, and neighbourhood 2 exhibited the lowest aggregation degree. The aggregation degree was higher in the time series impacted by the systems approach than the series in the first years of its implementation.

https://doi.org/10.4025/actasciagron.v44i1.53466

Morphology of immature stages, biological parameters and life table of Microtechnites bractatus (Hemiptera: Miridae) on different host plants
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Ribeiro, Luana Karolline

; Lara, Carlos Alexandre de

; Coelho Junior, Aloisio

; Ferreira, Paulo Sérgio Fiuza

; Resende, Juliano Tadeu Vilela de

; Bento, José Maurício Simões

; Nardi, Cristiane

Revista Brasileira de Entomologia

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2022, Volume 66 N. 3 elocation e20220016

Abstract: En | Text: En | PDF: En

ABSTRACT The garden fleahopper, Microtechnites bractatus (Say) (Hemiptera: Miridae), is associated with several cultivated plant species and, despite its economic importance, little is known about its development and performance in such hosts. We described here, the morphology of immature stages, and evaluated the biology of M. bractatus in beans, potatoes, white clover, alfalfa, and wheat. The bioassays were carried out in the laboratory under controlled temperature (25±2ºC), humidity (UR70±15%), and photoperiod (12L:12D). The eggs of M. bractatus are elongated and slightly curved, without respiratory projections and light yellow in color, becoming dark at the end of the incubation period. Nymphs present an oval-shaped body, a reddish color that intensifies along with the development and dimorphic wing pads in the fifth instar. In the bioassays, the host plants influenced the biological aspects of M. bractatus, both in the immature and adult stages. Nymph survival was higher in clover and alfalfa, while in wheat, it was lower. Clover-fed insects had the longest longevity. The fecundity parameters and egg viability were favored in insects that fed on clover and alfalfa. The fertility life table showed that feeding M. bractatus with clover provides a higher net reproduction rate (R0) and a higher finite ratio of population increase (ʎ). This study contributes to bioecological and behavioral studies on M. bractatus and provides data for the recognition and characterization of individuals in the immature stage.

https://doi.org/10.1590/1806-9665-rbent-2022-0016

Trajetórias formativas (auto)biográficas de educadores(as) negros(as) nas teses e dissertações brasileiras (2003-2021)
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Fialho, Lia Machado Fiuza

; Machado, Charliton José dos Santos

; Neves, Vanusa Nascimento Sabino

Revista Brasileira de História da Educação

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2022, Volume 22 elocation e220

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

Abstract: The objective was to understand the formative trajectories of afro-descendant educators from the (auto) biographical studies published by the Brazilian Digital Library of Theses and Dissertations from 2003 to 2021. A qualitative research was conducted, anchored in the state of art, which considered seven theses and 12 dissertations for thematic content analysis. Three categories emerged persistence of racial insult and racism in the school environment; trajectories to build a teacher; and resignification of the teaching praxis. The formative trajectories are marked by confrontations due to expressed or naturalized racism and the various material needs from childhood, however, there is a redefinition of educational praxis to overcome oppression and promote racial equality.

Resumen: El objetivo fue comprender las trayectorias formativas de los(as) educadores(as) afrodescendientes a partir de los estudios (auto)biográficos publicados por la Biblioteca Digital Brasileña de Tesis e Disertaciones de 2003 a 2021. Se realizó una investigación cualitativa, anclada en el estado del arte, que consideró siete tesis y 12 disertaciones para el análisis temático del contenido. Surgieron tres categorías: persistencia de insultos raciales y racismo en el entorno escolar; trayectorias para construir un docente; y resignificación de la praxis docente. Las trayectorias formativas están marcadas por enfrentamientos debido al racismo expresado o naturalizado y debido a las diversas necesidades materiales desde la niñez, sin embargo hay una redefinición de la praxis educativa para superar la opresión y promover la igualdad racial.

Resumo: Objetivou-se compreender as trajetórias formativas de educadores(as) negros(as) a partir dos estudos (auto)biográficos veiculados pela Biblioteca Digital Brasileira de Teses e Dissertações no período de 2003 a 2021. Realizou-se uma pesquisa qualitativa, ancorada no estado da arte, que considerou sete teses e 12 dissertações para análise temática do conteúdo. Emergiram três categorias: persistência da injúria racial e do racismo no âmbito escolar; trajetórias para se construir docente; e ressignificação da práxis docente. As trajetórias formativas são marcadas por enfrentamentos devido ao racismo expresso ou naturalizado e em razão das diversas carências materiais desde a infância, todavia há ressignificação da práxis educativa para superar a opressão e promover a igualdade racial.

https://doi.org/10.4025/rbhe.v22.2022.e220

Recommendations by the Scientific Department of Neuroimmunology of the Brazilian Academy of Neurology (DCNI/ABN) and the Brazilian Committee for Treatment and Research in Multiple Sclerosis and Neuroimmunological Diseases (BCTRIMS) on vaccination in general and specifically against SARS-CoV-2 for patients with demyelinating diseases of the central nervous system
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Becker, Jefferson

; Ferreira, Lis Campos

; Damasceno, Alfredo

; Bichuetti, Denis Bernardi

; Christo, Paulo Pereira

; Callegaro, Dagoberto

; Peixoto, Marco Aurélio Lana

; Sousa, Nise Alessandra De Carvalho

; Almeida, Sérgio Monteiro De

; Adoni, Tarso

; Santiago-Amaral, Juliana

; Junqueira, Thiago

; Pereira, Samira Luisa Apóstolos

; Gomes, Ana Beatriz Ayroza Galvão Ribeiro

; Pitombeira, Milena

; Paolilo, Renata Barbosa

; Grzesiuk, Anderson Kuntz

; Piccolo, Ana Claudia

; D´Almeida, José Arthur Costa

; Gomes Neto, Antonio Pereira

; Oliveira, Augusto Cesar Penalva De

; Oliveira, Bianca Santos De

; Tauil, Carlos Bernardo

; Vasconcelos, Claudia Ferreira

; Kaimen-Maciel, Damacio

; Varela, Daniel

; Diniz, Denise Sisterolli

; Oliveira, Enedina Maria Lobato De

; Malfetano, Fabiola Rachid

; Borges, Fernando Elias

; Figueira, Fernando Faria Andrade

; Gondim, Francisco De Assis Aquino

; Passos, Giordani Rodrigues Dos

; Silva, Guilherme Diogo

; Olival, Guilherme Sciascia Do

; Santos, Gutemberg Augusto Cruz Dos

; Ruocco, Heloisa Helena

; Sato, Henry Koiti

; Soares Neto, Herval Ribeiro

; Cortoni Calia, Leandro

; Gonçalves, Marcus Vinícius Magno

; Vecino, Maria Cecilia Aragón De

; Pimentel, Maria Lucia Vellutini

; Ribeiro, Marlise De Castro

; Boaventura, Mateus

; Parolin, Mônica Koncke Fiuza

; Melo, Renata Brant De Souza

; Lázaro, Robson

; Thomaz, Rodrigo Barbosa

; Kleinpaul, Rodrigo

; Dias, Ronaldo Maciel

; Gomes, Sidney

; Lucatto, Simone Abrante

; Alves-Leon, Soniza Vieira

; Fukuda, Thiago

; Ribeiro, Taysa Alexandrino Gonsalves Jubé

; Winckler, Thereza Cristina D’ávila

; Fragoso, Yara Dadalti

; Nascimento, Osvaldo José Moreira Do

; Ferreira, Maria Lucia Brito

; Mendes, Maria Fernanda

; Brum, Doralina Guimarães

; Glehn, Felipe Von

Arquivos de Neuro-Psiquiatria

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nov 2021, Volume 79 N. 11 Pages 1049 - 1061

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O DC de Neuroimunologia da ABN e o BCTRIMS trazem, nesse documento, as recomendações sobre vacinação da população com doenças desmielinizantes do sistema nervoso central (SNC) contra infecções em geral e contra o coronavírus da síndrome respiratória aguda grave 2 (SARS-CoV-2), causador da COVID-19. Destaca-se a gravidade do atual momento frente ao avanço da COVID-19 em nosso País, o que torna mais evidente e importante a criação de guia de referência para orientação aos médicos, pacientes e autoridades de saúde pública quanto à vacinação, meio efetivo e seguro no controle de determinadas doenças infecciosa. O DCNI/ABN e o BCTRIMS recomendam que os pacientes com doenças desmielinizantes do SNC (ex., EM e NMOSD) sejam constantemente monitorados, quanto a atualização do seu calendário vacinal, especialmente, no início ou antes da mudança do tratamento com uma droga modificadora de doença (DMD). É importante também salientar que as vacinas são seguras e os médicos devem estimular o seu uso em todos os pacientes. Evidentemente, deve ser dada especial atenção às vacinas com vírus vivos atenuados. Por fim, é importante que os médicos verifiquem qual DMD o paciente está em uso e quando foi feita a sua última dose, pois cada fármaco pode interagir de forma diferente com a indução da resposta imune.

ABSTRACT The Scientific Department of Neuroimmunology of the Brazilian Academy of Neurology (DCNI/ABN) and Brazilian Committee for Treatment and Research in Multiple Sclerosis and Neuroimmunological Diseases (BCTRIMS) provide recommendations in this document for vaccination of the population with demyelinating diseases of the central nervous system (CNS) against infections in general and against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19. We emphasize the seriousness of the current situation in view of the spread of COVID-19 in our country. Therefore, reference guides on vaccination for clinicians, patients, and public health authorities are particularly important to prevent some infectious diseases. The DCNI/ABN and BCTRIMS recommend that patients with CNS demyelinating diseases (e.g., MS and NMOSD) be continually monitored for updates to their vaccination schedule, especially at the beginning or before a change in treatment with a disease modifying drug (DMD). It is also important to note that vaccines are safe, and physicians should encourage their use in all patients. Clearly, special care should be taken when live attenuated viruses are involved. Finally, it is important for physicians to verify which DMD the patient is receiving and when the last dose was taken, as each drug may affect the induction of immune response differently.

https://doi.org/10.1590/0004-282x-anp-2021-0162 1 downloads

Evaluation of diagnosis and treatment practices of Brazilian neurologists among patients with multiple sclerosis
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Marin, Cássia Elisa

; Callegaro, Dagoberto

; Lana-Peixoto, Marco Aurélio

; Fernández, Oscar

; Gomes Neto, Antonio Pereira

; Vasconcelos, Claudia Cristina Ferreira

; d’Almeida, José Artur Costa

; Gonçalves, Marcus Vinícius Magno

; Mendes, Maria Fernanda

; Parolin, Mônica Koncke Fiuza

; Nascimento, Osvaldo

; Gama, Paulo Diniz da

; Dias-Carneiro, Rafael Paternò Castello

; Dias, Ronaldo Maciel

; Damasceno, Alfredo

; Becker, Jefferson

Arquivos de Neuro-Psiquiatria

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jul 2021, Volume 79 N. 7 Pages 598 - 606

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Introdução: Mudanças recentes dos critérios diagnósticos e nos tratamentos para Esclerose Múltipla (EM) promoveram um grande impacto na maneira com que os especialistas manejam a doença. Objetivos: Investigar fatores considerados no manejo de pacientes com EM, por neurologistas brasileiros, bem como identificar como estes contribuem para o diagnóstico e o tratamento da doença. Métodos: Participantes foram selecionados pelo Comitê Organizador (especialistas em EM responsáveis por desenvolver a pesquisa). Apenas especialistas em EM foram incluídos (neurologistas com fellowship em neuroimunologia ou que atendem, atualmente, mais de 30 pacientes com EM). Os links de acesso a um questionário foram distribuídos entre março de 2019 e janeiro de 2020, o qual consistia em cenários hipotéticos referentes à EM. Resultados: Neurologistas de 13 estados brasileiros responderam à pesquisa (n=94). No cenário de Síndrome Clínica Isolada, os participantes concordaram em tratar pacientes com alto risco de diagnóstico de EM no futuro, resultado não encontrado nos casos de Síndrome Radiológica Isolada, no qual metade dos participantes optaram por não tratar, mesmo em casos de alto risco. Nos casos de EM Remitente-Recorrente de baixa atividade, a escolha para tratamento foi interferon beta, acetato de glatirâmer ou teriflunomida, sendo trocado para fingolimode e natalizumabe quando de aumento da gravidade. Discordâncias foram encontradas referentes ao uso de medicações durante a gestação e seus períodos de washout. Conclusões: Este estudo identificou concordâncias e discordâncias entre neurologistas brasileiros sobre EM, as quais podem ser auxiliares nas futuras atualizações de protocolos, visando melhorar o manejo dos pacientes.

ABSTRACT Background: Recent changes to the diagnostic criteria for multiple sclerosis (MS) and new medications have had a major impact on the way in which specialists manage the disease. Objective: To investigate factors considered by Brazilian neurologists in managing MS, and to identify how these contribute to diagnosis and treatment. Methods: Potential participants were selected by a steering committee (MS experts who developed this survey). Only MS specialists were included in the study (neurologists who had completed a neuroimmunology fellowship or who were treating more than 30 MS patients). Links to the online questionnaire were distributed between March 2019 and January 2020. This questionnaire was composed of sections with hypothetical MS scenarios. Results: Neurologists from 13 Brazilian states responded to the survey (n = 94). In the clinically isolated syndrome (CIS) scenario, the respondents agreed to treat patients with a high risk of MS diagnosis, whereas in the radiologically isolated syndrome (RIS) half of the respondents opted not to treat, even among high-risk patients. In cases of low-activity relapsing-remitting MS (RRMS), the choice of treatment was distributed among interferon beta, glatiramer acetate and teriflunomide, which were changed to fingolimod and natalizumab, as RRMS severity increased. The topics in which disagreement was found included practices regarding use of disease-modifying therapy (DMT) for pregnant patients and the washout period required for some DMTs. Conclusions: This study enabled identification of areas of agreement and disagreement about MS treatment among Brazilian neurologists, which can be used to update future protocols and improve patient management.

https://doi.org/10.1590/0004-282x-anp-2020-0362 246 downloads

UTILIZAÇÃO DE LIVES COMO FERRAMENTA DE EDUCAÇÃO EM SAÚDE DURANTE A PANDEMIA PELA COVID-19
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Neves, Vanusa Nascimento Sabino

; Machado, Charliton José dos Santos

; Fialho, Lia Machado Fiuza

; Sabino, Raquel do Nascimento

Educação & Sociedade

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2021, Volume 42 elocation e240176

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivou-se compreender a experiência formativa realizada por meio de lives, com a temática “educação em saúde”, durante o confinamento social imposto pela Covid-19. Desenvolveu-se uma pesquisa de abordagem qualitativa, do tipo pesquisa-ação, que utilizou lives como veículo para a ação formativa. Realizaram-se nove lives: a maioria dos conteúdos educativos veiculados partiu da demanda do hospital e versava sobre o enfrentamento da Covid-19. Concluiu-se que as lives se apresentam como ferramentas importantes para operacionalizar a educação permanente em saúde, especialmente em contexto de pandemia, no entanto, elas excluem usuários do sistema público de saúde de maior vulnerabilidade social, que não possuem acesso à tecnologia móvel conectada à Internet.

ABSTRACT The objective was to understand the training experience carried out through online live videos called lives with the theme “health education”, during the social confinement imposed by COVID-19. A qualitative research-action was developed, which used lives as a vehicle for formative action. Nine lives were held: most of the educational content conveyed came from the demand of the hospital and dealt with coping with COVID-19. It is concluded that lives are presented as important tools to operationalize permanent health education, especially in the context of a pandemic. However, they excluded users of the public health system of greatest social vulnerability, who do not have access to mobile technology connected to the Internet.

RESUMEN Se objetivó comprender la experiencia de capacitación realizada mediante lives con el tema “educación para la salud” durante el encierro social impuesto por el COVID-19. Se desarrolló una investigación cualitativa de investigación-acción, que utilizaba lives como vehículo para la acción formativa. Se realizaron nueve lives: la mayor parte del contenido educativo transmitido provino de la demanda del hospital y se ocupó de hacer frente al COVID-19. Se concluyó que las lives se presentan como herramientas importantes para poner en práctica la educación permanente en salud, especialmente en el contexto de una pandemia; sin embargo, excluyen a los usuarios del sistema de salud pública de mayor vulnerabilidad social, que no tienen acceso a la tecnología móvil conectada a Internet.

https://doi.org/10.1590/es.240176 2690 downloads

10.

Migraine in 746 patients with multiple sclerosis
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Fragoso, Yara Dadalti

; Adoni, Tarso

; Alves-Leon, Soniza V.

; Apostolos-Pereira, Samira L.

; Carneiro, Marcos A. Diniz

; Chikota, Edila M.

; Diniz, Denise Sisterolli

; Eboni, Audred C. B.

; Gomes, Sidney

; Gonçalves, Marcus Vinicius M.

; Goncalves, Ricardo Pereira

; Inojosa, José Luiz

; Junqueira, Thiago F.

; Machado, Suzana Costa

; Malfetano, Fabiola Rachid

; Mansur, Letícia Fezer

; Mendes, Maria Fernanda

; Muniz, Andre

; Nobrega Junior, Adaucto W.

; Olival, Guilherme Sciascia do

; Parolin, Monica Fiuza

; Pimentel, Maria Lucia V.

; Rocha, Cristiane Franklin

; Ruocco, Heloisa Helena

; Santos, Gutemberg C.

; Siquineli, Fabio

; Soares, José Otavio D.

; Sousa, Nise Alessandra C.

; Tauil, Carlos Bernardo

; Winckler, Thereza Cristina A.

Arquivos de Neuro-Psiquiatria

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sep 2019, Volume 77 N. 9 Pages 617 - 621

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Enxaqueca piora o sofrimento do paciente que tem esclerose múltipla (EM). ID-migraine é uma ferramenta útil para seleção de pacientes com enxaqueca e Migraine Disability Assessment (MIDAS) é um questionário que avalia o impacto da doença. O objetivo do presente estudo foi avaliar a presença e impacto de enxaqueca em pacientes com EM. Métodos: Pacientes diagnosticados com EM e tratados em clínicas especializadas foram convidados a responder um questionário online se também apresentassem cefaleia. Resultados: O estudo incluiu 746 participantes com cefaleia e EM que preencheram completamente as respostas. Foram 625 mulheres e 121 homens, sendo 69% dos pacientes com idade entre 20 e 40 anos. Enxaqueca foi identificada em 404 pacientes (54,1%) e moderado a grave impacto da doença foi observado em 68,3% dos casos. Conclusão: Enxaqueca é uma cefaleia primária frequente e incapacitante relatada por pacientes com EM.

ABSTRACT Migraine adds to the burden of patients suffering from multiple sclerosis (MS). The ID-migraine is a useful tool for screening migraine, and the Migraine Disability Assessment questionnaire can evaluate disease burden. The aim of the present study was to assess the presence and burden of migraine in patients with MS. Methods: Patients diagnosed with MS attending specialized MS units were invited to answer an online survey if they also experienced headache. Results: The study included 746 complete responses from patients with MS and headache. There were 625 women and 121 men, and 69% of all the patients were aged between 20 and 40 years. Migraine was identified in 404 patients (54.1%) and a moderate-to-high burden of disease was observed in 68.3% of the patients. Conclusion: Migraine is a frequent and disabling type of primary headache reported by patients with MS.

https://doi.org/10.1590/0004-282x20190100 1666 downloads

11.

Hormone receptor-negative as a predictive factor for pathologic complete response to neoadjuvant therapy in breast cancer
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Silva, Luana Carolina Ferreira Fiuza

; Arruda, Lilian Silva Martins de

; David Filho, Waldec Jorge

; Cruz, Felipe José Silva Melo

; Trufelli, Damila Cristina

; del Giglio, Auro

einstein (São Paulo)

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2019, Volume 17 N. 1 elocation eAO3434

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo Definir um fator preditivo para resposta patológica completa, comparar os resultados oncológicos associados com o grau de resposta patológica, após quimioterapia neoadjuvante, e analisar a resposta patológica completa como fator prognóstico para sobrevivência global e livre de progressão de doença. Métodos Estudo retrospectivo de pacientes admitidas no Hospital Estadual Mário Covas e Hospital Anchieta, no período de 2008 a 2012, com câncer de mama localmente avançado. Foram utilizados status dos receptores hormonais, proteína HER2, grau histológico e nuclear, idade do paciente ao diagnóstico e tipo histológico do tumor. A avaliação patológica do tumor foi subdividida em resposta patológica completa, definida com ausência de tumor; resposta intermediária, considerada como um estádio favorável; e resposta ruim, considerando os pacientes pouco respondedores. As informações obtidas foram submetidas à análise estatística. Resultados Foram incluídas 243 pacientes. Verificou-se associação de resposta patológica completa entre HER-2 negativo, grau histológico 3, estadiamento III, receptor hormonal negativo, linfonodo positivo, maior idade e tumores mais avançados. Porém, após análise multivariada, o único fator preditivo de resposta patológica completa foi presença de receptor hormonal negativo. Ao analisar fatores prognósticos, receptor hormonal negativo permaneceu como variável independente de risco, e resposta patológica completa, como variável independente de proteção. Conclusão O receptor hormonal negativo é fator preditivo isolado de resposta patológica completa e fator de risco para menor sobrevida livre de doença e sobrevida global. Já a resposta patológica completa é fator protetor para estas mesmas análises de sobrevivência.

ABSTRACT Objective To define a predictive factor for pathologic complete response, compare the oncologic outcomes associated with the degree of pathologic response after neoadjuvant chemotherapy, and to analyze pathologic complete response as a prognostic factor for overall survival and progression-free survival. Methods A retrospective study of patients admitted to Hospital Estadual Mário Covas and Hospital Anchieta from 2008 to 2012, with locally advanced breast cancer. Hormone receptor status, HER2 status, histologic and nuclear grade, age upon diagnosis and histological type of the tumor were analyzed. Pathologic evaluation of the tumor was subdivided into pathologic complete response, defined by the absence of tumor; intermediate response, considered as a favorable stage; and poor response, considering low-responder patients. Data obtained were submitted to statistical analysis. Results The study included 243 patients. There was an association of pathologic complete response with HER-2 negative, histological grade 3, stage III, hormone receptor negative, positive lymph node, older age and more advanced tumors. However, after multivariate analysis the only predictor of pathologic complete response was the presence of negative hormone receptor. By analyzing the prognostic factors, hormone receptor negative was considered as an independent risk factor, and pathologic complete response was considered as an independent protective factor. Conclusion Hormone receptor negative is predictive of pathologic complete response and is an isolated risk factor for lower progression-free survival and overall survival. Pathologic complete response is a protective factor for these same survival analyses.

https://doi.org/10.31744/einstein_journal/2019ao3434 2781 downloads

12.

Educação inclusiva: aspectos históricos, políticos e ideológicos da sua constituição no cenário internacional
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Barbosa, Daniella de Souza

; Fialho, Lia Machado Fiuza

; Machado, Charliton José dos Santos

Actualidades Investigativas en Educación

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aug 2018, Volume 18 N. 2 Pages 598 - 618

Abstract: Es Pt En | Text: Es Pt En | PDF: Es | PDF: Pt | PDF: En

Resumen El imperativo ético que permite garantizar derechos humanos e igualdad a las personas con discapacidad por intermedio de la Educación Inclusiva es un paradigma relativamente reciente en el escenario brasileño y su efectividad es compleja. Se pretende desarrollar una investigación histórica, del tipo documental, respecto a las políticas públicas internacionales de Educación Especial con énfasis en los cambios paradigmáticos emergentes cronológicamente en Brasil. Se concluye que los siglos XVIII y XIX fueron marcados por la segregación homogeneizante de las personas con discapacidad en escuelas especiales y que, a partir del siglo XX, impulsadas por documentos internacionales, emergieron las clases especiales superadas por la ideología actual de igualdad e inclusión social con respecto a las diferencias que posibilita no solo la inclusión en la escuela regular, sino mecanismos de lucha para la igualdad de condiciones. Las reflexiones plantean que acuerdos internacionales impulsan el Brasil a alinear su política interna hacia la garantía de derechos humanos y de igualdad a las personas con discapacidad.

Resumo O imperativo ético de garantia de direitos humanos e igualdade às pessoas com deficiência, por intermédio da Educação Inclusiva, é paradigma relativamente recente no cenário brasileiro e sua efetivação é complexa. Objetiva-se desenvolver uma pesquisa histórica, do tipo documental, a respeito das políticas públicas internacionais de Educação Especial com ênfase nas mudanças paradigmáticas emergentes cronologicamente no Brasil. Conclui-se que os séculos XVIII e XIX foram marcados pela segregação homogeneizante das pessoas com deficiência em escolas especiais e que, a partir do século XX, impulsionadas por documentos internacionais, emergem as classes especiais superadas pela ideologia atual de igualdade e inclusão social com respeito às diferenças que possibilita não apenas a inclusão na escola regular, mas mecanismos de luta para igualdade de condições. As reflexões ensejam que acordos internacionais impulsionam o Brasil a alinhar sua política interna em direção à garantia de direitos humanos e igualdade às pessoas com deficiência.

Abstract The ethical imperative that guarantees human rights and equality for people with disabilities through Inclusive Education is a relatively recent paradigm in Brazilian scenario and its implementation is complex. The objective is to develop a historical, documentary-type research, a path on international public policies of Special Education with emphasis on paradigmatic changes emerging chronologically in Brazil. It is concluded that the eighteenth and nineteenth centuries were marked by the homogenizing segregation of people with disabilities in special schools and that, from the twentieth century onwards; special classes emerged, driven by international documents. Such classes were overcome the current ideology of equality and social inclusion towards the differences that make possible not only the inclusion in the regular school, but some mechanisms to fight for equality of conditions. The reflections show that the international discussions and agreements impel Brazil to align its internal policy towards the guarantee of human rights and equality for people with disabilities.

https://doi.org/10.15517/aie.v18i2.33213 11559 downloads

13.

Evaluation of the chemical composition and variability of the volatile oils from Trembleya parviflora leaves
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Farias, Wadson C.

; Ferreira, Heleno D.

; Sá, Stone

; Cunha, Luiz C.

; Oliveira Neto, Jerônimo R.

; Borges, Leonardo L.

; Paula, José R.

; Fiuza, Tatiana S.

Revista Brasileira de Farmacognosia

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aug 2018, Volume 28 N. 4 Pages 414 - 420

Abstract: En | Text: En | PDF: En

Abstract Trembleya parviflora (D. Don) Cogn., Melastomataceae, also known as "quaresmeira-branca", is a subshrub that is commonly used to treat verminosis, scabies, dermatoses, rheumatism, vaginal infections, ulcerations and wounds. The aim of this work was to perform a morphological study of T. parviflora, evaluate the composition and chemical variability of the volatile oils from the leaves, perform phytochemical screening of the powder from the leaves and to define parameters for quality control of the plant material. Macroscopic characterization of T. parviflora was carried out by naked eye in Serra dos Pireneus, Pirenópolis, Goiás for 12 months. Volatile oils were subjected to hydrodistillation with Clevenger apparatus and analyzed by gas chromatography-mass spectrometry. Phytochemical screening and ash and volatile compound content determination were performed by conventional techniques. T. parviflora has simple, oppositely crossed and petiolate leaves. The inflorescence of this plant is a cyme. The presence of coumarins, steroids, triterpenes, flavonoids and tannins was observed. The total ash content was 4.05 ± 0.02%; the insoluble ash content was 0.10 ± 0.03%; and the volatile compound content was 9.53 ± 0.02%. The major compounds present in the volatile oils were α-terpineol (2.7–16.5%), α-pinene (0.6–25.4%), β-pinene (2.7–23.1%), sabinene (1.2–14.1%), acetoxyeudesman-4-α-ol (0.6–6.3%) and 2,4a-8,8-tetramethyldecahydrocyclopropanaphtalene (2.4–24.4). Two clusters were identified: Cluster I represented the period with low levels of rainfall, and Cluster II represented the period with high levels of rainfall. This study provides data that can be applied for the quality control of powdered leaves and is the first description of the chemical composition and variability of the volatile oils from the leaves of T. parviflora.

https://doi.org/10.1016/j.bjp.2018.04.009 789 downloads

14.

Persuading with Narratives Against Gender Violence. Effect of Similarity with the Protagonist on Identification and Risk-Perception
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Igartua, Juan José

; Fiuza, Daniela

Palabra Clave

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jun 2018, Volume 21 N. 2 Pages 499 - 523

Abstract: Es En Pt | Text: Es En Pt | PDF: Es | PDF: En | PDF: Pt

Resumen Este estudio se enfoca en el análisis de los factores que pueden aumentar la efectividad persuasiva de las campañas de información por medio de narrativas. Se realizó un experimento en el que la similitud con el protagonista se manipuló en un video sobre una víctima de violencia de género. Se describió a la protagonista como si viviera en España y se dijo que era de nacionalidad española (gran similitud) o argentina (baja similitud). A continuación, las participantes (75 mujeres españolas) respondieron un cuestionario con medidas sobre el impacto emocional, la identificación con el protagonista y la percepción del riesgo de convertirse en víctima de abuso. Los resultados mostraron que la similitud con la protagonista tiene una influencia indirecta en la percepción del riesgo a través de las emociones negativas y la identificación.

Abstract This study focuses on analysis of the factors that can increase the persuasive effectiveness of information campaigns using narratives. An experiment was carried out in which similarity with the protagonist was manipulated in a video about a victim of gender violence. The protagonist was portrayed as living in Spain, and she was said to be Spanish (high similarity) or Argentinian (low similarity). The participants (75 Spanish women) then filled out a questionnaire with measures about emotional impact, identification with the protagonist, and risk perception about becoming a victim of abuse. Results showed that similarity with the protagonist has an indirect influence on risk perception through negative emotions and identification.

Resumo Este estudo se enfoca na análise dos fatores que podem aumentar a eficácia persuasiva das campanhas de informação através de narrativas. Realizou-se um experimento em que a semelhança com o protagonista foi manipulada em um vídeo sobre uma vítima de violência de gênero. Descreveu-se a protagonista como se esta morasse na Espanha, e foi dito que era de nacionalidade espanhola (grande semelhança) ou argentina (baixo nível de semelhança). A seguir, as participantes (75 mulheres espanholas) responderam um questionário com medidas sobre o impacto emocional, a identificação com o protagonista e a percepção do risco de tornar-se vítima de abuso. Os resultados revelaram que a semelhança com a protagonista tem uma influência indireta na percepção do risco através das emoções negativas e da identificação.

https://doi.org/10.5294/pacla.2018.21.2.10 594 downloads

15.

Phytochemistry and antimicrobial activity of Campomanesia adamantium
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Sá, Stone

; Chaul, Luíza T.

; Alves, Virgínia F.

; Fiuza, Tatiana S.

; Tresvenzol, Leonice M.F.

; Vaz, Boniek G.

; Ferri, Pedro H.

; Borges, Leonardo L.

; Paula, José R.

Revista Brasileira de Farmacognosia

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jun 2018, Volume 28 N. 3 Pages 303 - 311

Abstract: En | Text: En | PDF: En

ABSTRACT Campomanesia adamantium (Cambess.) O. Berg., Myrtaceae, is a plant popularly used for its anti-inflammatory, anti-diarrhoeal and urinary antiseptic activities. The aims of this study were to obtain the crude ethanolic extract and the hexane, dichloromethane, ethyl acetate, aqueous and concentrated aqueous tannin fractions from C. adamantium leaves, perform biomonitored fractionation to isolate and identify chemical compounds, study the chemical composition of the volatile oils of the leaves and flowers and test the antimicrobial activity of the ethanolic extract, fractions, isolated substances and volatile oils. Phytochemical screening and chromatographic and spectrometric techniques were used. Volatile oils were isolated by hydrodistillation in a Clevenger apparatus and analyzed by gas chromatography/mass spectrometry. The antimicrobial activity was tested by a broth microdilution test. The component stictane-3,22-diol was isolated and identified from the hexane fraction, while valoneic and gallic acid were isolated and identified from the concentrated aqueous tannin fraction. The major constituents of the volatile oils of the leaves were verbenene (13.91%), β-funebrene (12.05%) and limonene (10.32%), while those of the volatile oils of the flowers were sabinene (20.45%), limonene (19.33%), α-thujene (8.86%) and methyl salicylate (8.66%). Antibacterial activity was verified for the hexane fraction, while antifungal activity was observed for the aqueous fraction and concentrated aqueous tannin fraction and for vanoleic acid. These results may justify the popular use of C. adamantium.

https://doi.org/10.1016/j.bjp.2018.02.008 902 downloads

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