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ABSTRACT Drug repositioning seeks to discover new applications for a drug that has already been approved in the market, resulting in faster and lower cost solutions, generally used for diseases that receive little investment, such as cutaneous leishmaniasis. In this context, hesperidin, commercially approved as Daflon®, is a flavonoid that belongs to the chalcones group, a class that has antileishmanial potential. The present study evaluated the in vitro and in vivo antileishmanial activity of commercial hesperidin. Hesperidin (9 to 0.56 mg mL-1) was tested against promastigote and amastigote forms of four dermotropic species of Leishmania, namely L. (L.) amazonensis, L. (V.) guyanensis, L. (V.) braziliensis and L. (V.) naiffi. For the in vivo tests, hamsters were infected in the snout and the lesions were treated with intralesional hesperidin. The treatment effectiveness was assessed by measuring the total volume of the lesion on the snout and determining the parasitic load. The in vitro results showed moderate toxicity in murine macrophages, with higher efficacy in L. (L.) amazonensis when compared to the other species tested. The in vivo results showed that hesperidin was able to gradually reduce the size of lesions by L. (L.) amazonensis, although it did not induce clinical and parasitological cure. Thus, hesperidin showed potential in in vitro tests against L. (L.) amazonensis and further studies with new formulations and experimental treatment schemes should be carried out.

RESUMO O reposicionamento de medicamentos busca descobrir novas aplicações para um medicamento já aprovado no mercado, resultando em soluções mais rápidas e de menor custo, geralmente utilizadas para doenças que recebem pouco investimento, como a leishmaniose tegumentar. Nesse contexto, a hesperidina, aprovada comercialmente como Daflon®, tem despertado interesse científico por ser um flavonoide pertencente ao grupo das chalconas, classe que possui potencial antileishmania. O presente estudo avaliou a atividade antileishmania in vitro e in vivo da hesperidina comercial. A hesperidina (9 a 0,56 mg mL-1) foi testada contra as formas promastigota e amastigota de quatro espécies dermotrópicas de Leishmania, sendo elas L. (L.) amazonensis, L. (V.) guyanensis, L. (V.) braziliensis e L. (V.) naiffi. Para os testes, os hamsters foram infectados no focinho e as lesões tratadas com hesperidina intralesional, cuja eficácia foi avaliada através da aferição do volume total da lesão no focinho e a determinação da carga parasitária. Os resultados in vitro demonstraram toxicidade moderada em macrófagos murinos e melhor eficácia em Leishmania (L.) amazonensis quando comparados às demais espécies testadas. Os resultados in vivo mostraram que a hesperidina foi capaz de reduzir gradativamente o tamanho das lesões causadas por L. (L.) amazonensis, embora não tenha induzido a cura clínica e parasitológica. Assim, a hesperidina mostrou-se promissora em estudos in vitro contra Leishmania (L.) amazonensis e novos estudos com novas formulações e esquemas de tratamento experimental devem ser realizados.

https://doi.org/10.1590/1809-4392202203181

Different methods for assessing glomerular filtration rate in the elderly
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Almeida, Gilsirene Scantelbury de

; Toledo, Noeli das Neves

; Matos, Miharu Maguinoria Matsuura

; Martin, Luis Cuadrado

; Franco, Roberto Jorge da Silva

Revista da Associação Médica Brasileira

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2024, Volume 70 N. 1 elocation e20221101

Abstract: En | Text: En | PDF: En

SUMMARY OBJECTIVE: The objective of this study was to identify the best method to replace cystatin C in the evaluation of glomerular filtration in the elderly. METHODS: Individuals over 60 years of age from a primary care center were studied. Blood was collected to determine creatinine and cystatin C and 24-h urine. Three methods were compared to determine glomerular filtration: Creatinine clearance, Cocroft-Gault, modification of diet in renal disease, and Collaboration Epidemiology of Chronic Kidney Disease based on creatinine, considering as a reference the determination of glomerular filtration using the cystatin-based Chronic Kidney Disease Epidemiology Collaboration equation. The statistical methods used were linear regression, Bland-Altman curve, and receiver operating characteristic. RESULTS: A total of 180 elderly people were evaluated, but 14 patients were lost from the sample, resulting in a total of 166 patients. The average age of patients was 66.9±6.1 years, and 69.8% were females. Regarding the number of patients eligible for the study, there were 12 black, 108 brown, and 46 white, 42.77% hypertensive, and 38.3% diabetic. Glomerular filtration was less than 60 mL/min in 22.28% of patients. Regarding the evaluation of the different equations, the correlation coefficient was lower for creatinine clearance and progressively higher for Cocroft-Gault, modification of diet in renal disease, and Collaboration Epidemiology of Chronic Kidney Disease based on creatinine. The Bland-Altman diagram and the receiver operating characteristic curve showed similar performance to the correlation coefficient for the different equations evaluated. CONCLUSION: Collaboration Epidemiology of Chronic Kidney Disease based on creatinine presented the best performance. Creatinine debug had the worst performance, which reinforces the idea that 24-h urine collection is unnecessary in these patients.

https://doi.org/10.1590/1806-9282.20221101

First occurrence of bidens mottle virus in Brazil: biological and molecular characterization of isolates infecting Zinnia sp. and Bidens pilosa
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Favara, Gabriel Madoglio

; Ferro, Camila Geovana

; Bello, Vinicius Henrique

; Oliveira, Felipe Franco de

; Kraide, Heron Delgado

; Ribeiro Junior, Marcos Roberto

; Krause-Sakate, Renate

; Kitajima, Elliot Watanabe

; Rezende, Jorge Alberto Marques

Scientia Agricola

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2024, Volume 81 elocation e20230078

Abstract: En | Text: En | PDF: En

ABSTRACT Zinnia sp. and hairy beggartick (Bidens pilosa) plants exhibiting symptoms of possible virus infection were found in the municipality of Santa Bárbara d’Oeste, São Paulo State, Brazil. Flexuous filamentous particles and cytoplasmatic inclusions typical of potyvirus infection were observed by transmission electron microscopy, respectively, in leaf extracts and cells of symptomatic leaves. Infection of both plants with bidens mottle virus (BiMoV) was confirmed by RT-PCR using potyvirus universal primers, followed by nucleotide sequencing of the amplicons. The nearly complete genome sequence of the Brazilian isolate, named BiMoV-BR, is 9700 nucleotides long and shares 95.6 % identity with the corresponding nucleotide sequence of a BiMoV isolate from the United States. BiMoV-BR was mechanically transmitted and caused systemic infection on plants of Zinnia sp., hairy beggarstick, sunflower (Helianthus annuus), and lettuce (Lactuca sativa). Myzus persicae transmitted the virus to Zinnia sp. plants with efficacy of 8 % and 42 %, using one and ten aphids per plant, respectively. This is the first detection of BiMoV in Brazil. Further studies are necessary to evaluate the distribution of this potyvirus in the country.

https://doi.org/10.1590/1678-992x-2023-0078

Characterization of fresh and hardened state properties of grouts for use in structural masonry
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Mesquita, José Augusto Ferreira Sales de

; Barros, Mércia Maria Semensato Bottura de

; Franco, Luiz Sérgio

; Pileggi, Rafael Giuliano

; Romano, Roberto Cesar de Oliveira

Revista IBRACON de Estruturas e Materiais

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2024, Volume 17 N. 2 elocation e17205

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O graute é um material normalmente aplicado para melhorar as propriedades mecânicas da alvenaria estrutural. Assim, a demanda pela utilização do grautes vem crescendo paralelamente à demanda por alvenaria estrutural. Sem diretrizes específicas para dosagem, esses produtos geralmente são preparados no local com base nos mesmos conceitos para preparo de concretos comuns. Várias propriedades do graute ainda precisam ser investigadas e compreendidas como ineficiência dos parâmetros de dosagem, resultando na produção de grautes não ecoeficientes. Desta forma, existe uma demanda por estudos técnico-científicos que auxiliem no desenvolvimento de diretrizes para dosagens de grautes. Este trabalho avalia as propriedades reológicas e do endurecidas de composições de grautes que simulam condições de campo para mostrar a inadequação do método de dosagem, demonstrando uma maneira de entender essa lacuna na tecnologia. A pesquisa investiga como as mudanças na relação água/cimento, para aumentar trabalhabilidade, afetariam as propriedades de estado fresco e endurecido de grautes para alvenaria estrutural. A mistura dos grautes foi realizada em um reômetro que permitiu determinar o comportamento e os parâmetros reológicos durante a mistura e em diferentes condições de cisalhamento. A resistência à compressão, a porosidade e a permeabilidade ao ar foram as propriedades avaliadas no estado endurecido. Os resultados mostraram que composições com maior teor de cimento não necessariamente refletiram propriedades mecânicas melhores, uma vez que não houve alterações estatística, pois outras variáveis também foram alteradas. Os resultados da pesquisa sugerem que o método de projeto usado em obra pode não ser apropriado o que pode resultar no desperdício de materiais cimentícios e composições não ecoeficientes. estrutural Assim dosagem comuns ecoeficientes forma técnicocientíficos técnico científicos tecnologia águacimento água água/cimento trabalhabilidade cisalhamento compressão melhores estatística alteradas

Abstract Grout is a material usually applied to enhance the mechanical properties of structural masonry. As such, the demand for grout has been growing parallel to the demand for structural masonry. Without guidelines for grout mixing design, these products are often prepared on-site based on the same concepts used for preparing ordinary Portland cement-based concretes. Several grout properties still need to be investigated and understood due to this mixing-design approach, and consequently, the production of ecoefficient grouts is a secondary priority. Due to these obstacles, there is a demand for technical-scientific studies to aid with developing grout design guidelines. This work evaluates the rheological and hardened properties of grout compositions that simulate in-field conditions to show the inadequacy of the mixing design method and a way to understand this lack in the technology. The research investigates how the changes in the water-to-cement ratio, to increase the strength, would affect the fresh and hardened state properties of grouts for structural masonry. The grout’s mixing was done in a rheometer which made it possible to determine the rheological behaviour and parameters during mixing and under different shear conditions. Compressive strength, porosity, and air-permeability were evaluated in the hardened state. The results showed that compositions with more cement content does not necessarily reflect enhanced mechanical properties since the differences were not statistically significant, because other variables were also changed. The research findings suggest that the design method used in practice may not be appropriate and potentially result in the waste of cementitious materials and no-eco-friendly compositions. masonry such onsite site cementbased concretes mixingdesign approach consequently priority obstacles technicalscientific technical scientific infield field technology watertocement water ratio strength s porosity airpermeability air permeability significant changed noecofriendly no eco friendly

https://doi.org/10.1590/s1983-41952024000200005

Third National Registry of Cardiac Rehabilitation Programs in Mexico (RENAPREC III-2022)
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Lara-Vargas, Jorge A.

; Ilarraza-Lomelí, Hermes

; García-Saldivia, Marianna

; Pineda-García, Alfredo D.

; Leyva-Valadez, Eduardo A.

; Justiniano-Cordero, Samuel

; Sahagún-Olmos, Roberto

; Zavala-Ramírez, Juana

; Cassaigne-Guasco, María E.

; Sánchez-Limón, Edgar-F

; Castañeda-López, Javier

; Cerón-Enríquez, Norma

; Ku-González, Andrés

; Arteaga-Martínez, Rodolfo

; Hinojosa-López, Tania

; Vergara-Guzmán, Jéssica

; Pérez-Vázquez, Daniel I.

; Gasca-Zamudio, Pedro D.

; Aranda-Ayala, Zulema L.

; Vacío-Reyes, Martha E.

; Reza-Orozco, Marco

; Alcocer-Gamboa, Miguel A.

; Hernández-González, Pedro A.

; Pérez-Reyes, Angélica A.

; Núñez-Urquiza, Juan P.

; Alonso-Sánchez, Jesús

; Franco-Valles, Sarahí

; Romo-Escamilla, Ricardo E.

; Nuriulú-Escobar, Patricia

; Serna-Santamaría, Iván

; Avilés-González, Jorge

; Salgado-Solorio, María C.

; Muñoz-Gutiérrez, Luz M.

; Mendoza-Díaz, Pedro M.

; Ávila-Estrada, Ángel

; Morales-Medina, Carlos

; Lara-Vázquez, Eduardo

; Rodríguez-Herrera, Paulina

; Galván-López, María

; Segoviano-Mendoza, Georgina

; De-la-Torre-Cruz, Fabiola

; Jiménez-Campos, Cecilia

; Ramírez-Meléndez, Alejandra

; Almaraz-Ríos, Alejandro

; González-Bonilla, Mezthly

; Rojano-Castillo, Jessica

; Rius-Suarez, María D.

Archivos de cardiología de México

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dec 2023, Volume 93 N. 4 Pages 405 - 416

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

resumen está disponible en el texto completo

Abstract Introduction: In Mexico, cardiac rehabilitation (CR) as an interdisciplinary intervention with therapeutic impact in patients with heart disease is growing. There is the need to know actual conditions of CR in our country. Objectives: The objective of this National Registry is to follow-up those existing and new CR units in Mexico through the comparison between the two previous registries, RENAPREC-2009 and RENAPREC II-2015 studies. This is a descriptive study focused on diverse CR activities such as assistance training, and certification of health professionals, barriers, reference, population attended, interdisciplinarity, permanence over time, growth prospects, regulations, post-pandemic condition, integrative characteristics, and scientific research. Results: Data were collected from 45 CR centers in the 32 states, 75.5% are private practice units, 67% are new, 33% were part of RENAPREC II-2015, and 17 have continued since 2009. With a better distribution of CR units along the territory, the median reference of candidates for CR programs is 9% with a significant reduction into tiempo of enrollment to Phase II admission (19 ± 11 days). Regarding to previous registries, the coverance of Phases I, II, and III is 71%, 100%, and 93%, respectively; and a coverance increases in evaluation, risk stratification, and prescription, more comprehensive attendance and prevention strategies. Conclusions: CR in Mexico has grown in the past 7 years. Even there is still low reference and heterogeneity in specific processes, there are strengths such as interdisciplinarity, scientific professionalization of specialists, national diversification, and an official society that are consolidated over time.

https://doi.org/10.24875/acm.22000235

[SciELO Preprints] - ESTIMATE OF THE CARBON FOOTPRINT IN THE SOY AND CORN AGRICULTURAL SECTOR IN MATO GROSSO
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Vieira, Mauricio Franco, Cleiton Guzatti, Natalie Silva, Roberto Weber da Figueiredo, Adriano Marcos Rodrigues

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Publication date: 2023-09-20

Abstract: En Pt

The carbon footprint (CP) emerged with the aim of managing greenhouse gas (GHG) emissions and is one of several ways to measure its impacts. This work aims to evaluate the carbon footprint in the soybean and corn agricultural sector in Mato Grosso. The estimate was calculated taking into account individual carbon footprints from the use of fertilizer, electricity for irrigation, N2O emissions and from the use of pesticides. The estimate was made for the period from 2004 to 2022. The methodology used was based on the work of cheng et al. (2011). When analyzing the results of the annual Carbon Footprint, a reduction of values in carbon intensity per quantity produced to 0.21980 in hectares can be seen. When comparing the results obtained by Cheng et al. (2011), the average production intensity for the period from 1993 to 2007 was 0.110 tonC/ton while the average in the state of Mato Grosso for the soybean crop, in the period between 2004 to 2022, was 0.21980 tonC /ton . When considering the corn crop, the carbon intensity results per amount produced were even lower compared to soybeans, 0.08224 tonC/ton., which demonstrates that crop rotation is too important when measuring the carbon footprint in the agricultural sector.

A pegada de carbono (PC) surgiu com o intuito de administrar as emissões de gases de efeito estufa (GEE) e é uma das várias formas de se medir seus impactos. Este trabalho tem como objetivo avaliar a pegada de carbono no setor agrícola da soja e milho em Mato Grosso. A estimativa foi calculada levando em consideração as pegadas de carbono individuais do uso de fertilizante, eletricidade para irrigação, das emissões de N2O e advindas do uso de agrotóxicos. A estimativa foi feita para o período de 2004 a 2022. A metodologia utilizada baseou-se no trabalho de cheng et al. (2011). Ao analisar os resultados da Pegada de Carbono anual, percebe-se uma redução de valores em intensidade de carbono por quantidade produzida para 0,21980 em hectares. Ao comparar os resultados obtidos por Cheng et al. (2011), a intensidade em produção média para o período de 1993 a 2007 foi de 0,110 tonC/ton enquanto que a média no estado de Mato Grosso para a cultura da soja, no período entre 2004 a 2022, foi de 0,21980 tonC/ton. Ao considerar a cultura do milho, os resultados de intensidade de carbono por quantidade produzida foram ainda menores se comparados aos da soja, 0,08224 tonC/ton., o que demonstra que a rotação de culturas é demasiado importante ao medir a pegada de carbono no setor agrícola.

https://doi.org/10.1590/SciELOPreprints.6430

Desarrollo y validación de una escala de percepción de riesgo de COVID-19 en Perú
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Zeladita-Huaman, Jhon Alex

; Franco-Chalco, Eduardo

; Zegarra-Chapoñan, Roberto

; Iguiñiz-Romero, Ruth

; Amemiya-Hoshi, Isabel

Revista Peruana de Medicina Experimental y Salud Pública

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jun 2023, Volume 40 N. 2 Pages 170 - 178

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

RESUMEN Objetivos. Desarrollar y validar una escala de percepción de riesgo ante la COVID-19 (PR-COVID-19-PE) en población peruana. Materiales y métodos. Estudio transversal psicométrico, realizado en el 2022. En la fase 1 se diseñó la escala inicial mediante revisión teórica, grupos focales, panel de expertos y revisión documental de escalas. En la fase 2 se determinó la escala mediante juicio de expertos y una prueba piloto. En la fase 3 se hizo una encuesta virtual en 678 pobladores peruanos adultos. Se efectuó un análisis factorial confirmatorio. Para determinar la validez de criterio se realizó un análisis correlacional (r de Pearson) con una escala válida de percepción de riesgo y la escala de miedo a la COVID-19. Resultados. La PR-COVID-19-PE está compuesta por dos dimensiones (cognitivo y emocional), presentó buen ajuste en la validez de constructo (x2/gl=2,34, Comparative Fit Index = 0,96, Tucker-Lewis Index = 0,96, Root Mean Square Error of Approximation = 0,05 y Standarized Root Mean-Square = 0,07) y óptima consistencia interna (ώ=0,88). Asimismo, reportó correlación con otra escala de percepción de riesgo ante la COVID-19 (r=0,70, p<0,001) y miedo a la COVID-19 (r = 0,41, p < 0,001). Además, presenta invarianza métrica y escalar tanto por sexo como por nivel educativo. Conclusiones. La escala PR-COVID-19-PE presentó adecuada confiabilidad y validez de contenido, constructo y criterio. Constituye un instrumento para medir la percepción de riesgo ante la COVID-19 en poblaciones similares. Sin embargo, se requiere estudios adicionales en diferentes grupos poblacionales.

ABSTRACT Objectives. To develop and validate a risk perception scale for COVID-19 (PR-COVID-19-PE) in the Peruvian population. Materials and methods. Psychometric cross-sectional study conducted in 2022. In phase 1, in order to design the scale, we carried out a theoretical review and a documentary review of scales, we also used focus groups as well as an expert panel. Phase 2 included expert judgment and a pilot test. A virtual survey was conducted among 678 Peruvian adults during phase 3. A confirmatory factor analysis was carried out as well. We used a correlational analysis (Pearson’s r) with a valid risk perception scale and the COVID-19 fear scale to determine criterion validity. Results. The PR-COVID-19-PE has two dimensions (cognitive and emotional) and showed good fit during construct validity (x2/gl=2.34, Comparative Fit Index=0.96, Tucker-Lewis Index=0.96, Root Mean Square Error of Approximation= 0.05 and Standardized Root Mean-Square=0.07) and optimal internal consistency (ώ=0.88). Likewise, the PR-COVID-19-PE showed correlation with another COVID-19 risk perception scale (r=0.70, p< 0.001) and a fear of COVID-19 scale (r=0.41, p<0.001). In addition, it presents metric and scalar invariance by both sex and educational level. Conclusions. The PR-COVID-19-PE scale showed adequate reliability and content, construct and criterion validity. It is an instrument that can measure COVID-19 risk perception in similar populations. However, further studies are required for different populations.

https://doi.org/10.17843/rpmesp.2023.402.12289

Cancelling crusades as a strategy of societal reaction
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Xavier, José Roberto Franco

; Tavares, Inês Ferreira Dias

; Chaves, Sabrina Ribeiro

Revista Direito e Práxis

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jun 2023, Volume 14 N. 2 Pages 827 - 858

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract In this theoretical essay, we shed light on new forms of public stigmatisation and their possible outcomes for the criminal justice system. We present some examples of the phenomenon we name “cancelling crusade” in this paper. We try to describe it step by step, then bring the theoretical framework. Finally, we analyse the impacts of these cancelling crusades on the criminal justice system.

Resumo Neste ensaio teórico, tenta-se entender novas formas de estigmatização e seus resultados para o sistema de justiça criminal. Apresentam-se alguns exemplos do fenômeno aqui chamado “cruzada de cancelamento”. Descreve-se o seu passo-a-passo e um quadro teórico é proposto. Enfim, analisam-se os impactos dessas cruzadas de cancelamento sobre o sistema de justiça criminal.

https://doi.org/10.1590/2179-8966/2022/60100i

One-year impact of COVID-19 pandemic on renal replacement therapy and kidney transplantation in a tertiary center in Southern Brazil
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Teichmann, Pedro do Valle

; Moschetta, Marina Oliboni

; Franco, Rodrigo Fontanive

; Vicari, Alessandra Rosa

; Nunes, Gérson Luiz da Silva

; Lazzaretti, Maria Angela Kalil Nader

; Gomes, Miriam Gressler

; Dorigoni, Silvia Maria

; Dall’Agnol, Paulo Roberto

; Klafke, Adriana

; Thomé, Fernando Saldanha

; Spuldaro, Fabio

; Agra, Homero

; Almeida, Rafael de

; Lara, Darlan Martins

; Bauer, Andrea Carla

; Karhol, Cristina

; Manfro, Roberto Ceratti

Brazilian Journal of Nephrology

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jun 2023, Volume 45 N. 2 Pages 210 - 217

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT Introduction: Patients on renal replacement therapy (RRT) and kidney transplant recipients (KTR) present multiple factors that may increase the risk of death from coronavirus disease 2019 (COVID-19). This study aimed to evaluate the incidence and impact of COVID-19 in RRT patients and KTRs. Methods: Between March 2020 and February 2021, we monitored the RRT population of thirteen dialysis facilities that refer patients for transplantation to our center, a tertiary hospital in Southern Brazil. In the same period, we also monitor COVID-19 incidence and mortality in our KTR population. Demographical, clinical, and COVID-19-related information were analyzed. Results: We evaluated 1545 patients in the dialysis centers, of which 267 (17.4%) were infected by COVID-19 and 53 (19.9%) died. Among 275 patients on the kidney transplant waiting list, 63 patients (22.9%) were infected and seven (11.1%) died. COVID-19 was the leading cause of death (29.2%) among patients on the waiting list. Within the population of 1360 KTR, 134 (9.85%) were diagnosed with COVID-19 and 20 (14.9%) died. The number of kidney transplants decreased by 56.7% compared with the same period in the previous twelve months. Conclusion: In the study period, patients on RRT and KTRs presented a high incidence of COVID-19 and high COVID-19-related lethality. The impact on the patients on the transplant waiting list was less pronounced. The lethality rate observed in both cohorts seems to be related to age, comorbidities, and disease severity.

Resumo Introdução: Pacientes em terapia renal substitutiva (TRS) e receptores de transplante renal (RTR) apresentam múltiplos fatores que podem aumentar o risco de óbito por doença do coronavírus 2019 (COVID-19). Este estudo teve como objetivo avaliar incidência e impacto da COVID-19 em pacientes em TRS e RTR. Métodos: Entre Março de 2020 e Fevereiro de 2021, monitoramos a população em TRS de treze unidades de diálise que encaminham pacientes para transplante ao nosso centro, um hospital terciário no Sul do Brasil. No mesmo período, também monitoramos a incidência e mortalidade da COVID-19 em nossa população de RTR. Foram analisadas informações demográficas, clínicas e relacionadas à COVID-19. Resultados: Avaliamos 1545 pacientes nos centros de diálise, dos quais 267 (17,4%) foram infectados pela COVID-19 e 53 (19,9%) foram a óbito. Entre 275 pacientes na lista de espera para transplante renal, 63 (22,9%) foram infectados e sete (11,1%) foram a óbito. COVID-19 foi a principal causa de óbito (29,2%) entre pacientes na lista de espera. Dentre a população de 1360 RTR, 134 (9,85%) foram diagnosticados com COVID-19 e 20 (14,9%) foram a óbito. O número de transplantes renais diminuiu em 56,7% comparado ao mesmo período nos doze meses anteriores. Conclusão: No período do estudo, pacientes em TRS e RTR apresentaram alta incidência de COVID-19 e alta letalidade relacionada à COVID-19. O impacto nos pacientes na lista de espera para transplante foi menos pronunciado. A taxa de letalidade observada em ambas as coortes parece estar relacionada à idade, comorbidades e gravidade da doença.

https://doi.org/10.1590/2175-8239-jbn-2022-0034en

10.

Desarrollo y validación de una escala de percepción de riesgo de COVID-19 en Perú
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Zeladita-Huaman, Jhon Alex

; Franco-Chalco, Eduardo

; Zegarra-Chapoñan, Roberto

; Iguiñiz-Romero, Ruth

; Amemiya-Hoshi, Isabel

Revista Peruana de Medicina Experimental y Salud Publica

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apr 2023, Volume 40 N. 2 Pages 170 - 178

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

https://doi.org/10.17843/rpmesp.2023.402.12289

11.

Hipertensão em mulheres presas no Brasil: muito além do biológico
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Silva, Paula Negrão da

; Kendall, Carl

; Silva, Ana Zaira da

; Mota, Rosa Maria Salani

; Araújo, Larissa Fortunato

; Pires Neto, Roberto da Justa

; Leal Júnior, Francisco Marto Pinheiro

; Macena, Raimunda Hermelinda Maia

; Kerr, Ligia Regina Franco Sansigolo

Ciência & Saúde Coletiva

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jan 2023, Volume 28 N. 1 Pages 37 - 48

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Objetivou-se estimar a prevalência de hipertensão arterial (HA) e os fatores de risco associados em mulheres presas. Utilizou-se dados do Inquérito Nacional de Saúde na População Penitenciária Feminina e em Servidoras Prisionais, investigando-se características sociodemográficas, fatores das prisões, comportamentos e condições de saúde. As informações foram coletadas por meio de questionário autoaplicado, sendo a magnitude da associação estimada por odds ratio e intervalo de confiança de 95%. Das 1.327 participantes, 24,4% eram hipertensas, a maioria tinha 31 anos ou mais (54,6%), 51,5% autorreferiram etnia/cor parda. Após mutual ajustamento pelos fatores de risco associados na análise bivariada, observou-se relação direta e com gradiente entre idade e HA, em que idade igual/maior a 41 anos foi associada independentemente com uma chance sete vezes maior de ter HA, se comparado a quem tem menos de 25 anos. Aquelas que autorreferiram etnia/cor negra apresentaram colesterol alto e estavam obesas, também foram associadas de forma independente com maior prevalência de HA. O maior número de pessoas com que a presa divide cela esteve associado à maior prevalência de há, sem uma relação dose-resposta. Conclui-se que idade, etnia/cor, obesidade, inatividade física e estresse são fatores de risco para HA em mulheres presas.

Abstract The scope was to estimate the prevalence of arterial hypertension (AHT) and associated risk factors among female prisoners. Data from the National Health Survey of the Female Prison Population and Prison Guards were used, investigating sociodemographic variables, prison characteristics, health behaviors and conditions. Information was collected through a self-administered questionnaire, and the magnitude of the association was estimated by the odds ratio and 95% confidence interval. Of the 1,327 prisoner participants, 24.4% were hypertensive, the majority were 31 years of age or older (54.6%), and 51.5% self-reported mixed race. After adjustment for associated risk factors in the bivariate analysis, a direct relationship between age and AHT was observed, in which age equal to/over 41 years was independently associated with a 7-fold greater chance of having AHT, compared to those under 25 years of age. Those who self-reported mixed race, had high cholesterol, were obese and were also independently associated with a higher prevalence of AHT. The greater the number of people with whom the inmate shares a cell was associated with a higher prevalence of AHT, but without a dose-response relationship. The conclusion drawn is that age, race, obesity, physical inactivity and stress are risk factors for AHT in female prisoners.

https://doi.org/10.1590/1413-81232023281.10672022

12.

Hipertensão em mulheres presas no Brasil: muito além do biológico
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Silva, Paula Negrão da

; Kendall, Carl

; Silva, Ana Zaira da

; Mota, Rosa Maria Salani

; Araújo, Larissa Fortunato

; Pires Neto, Roberto da Justa

; Leal Júnior, Francisco Marto Pinheiro

; Macena, Raimunda Hermelinda Maia

; Kerr, Ligia Regina Franco Sansigolo

Ciência & Saúde Coletiva

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jan 2023, Volume 28 N. 1 Pages 37 - 48

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1413-81232023281.10672022

13.

Development of assays for the characterization of sperm motility parameters, viability, and membrane integrity in the epididymis and vas deferens of the greater rhea (Rhea americana)
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Bezerra, Luana Grasiele Pereira

; Silva, Andréia Maria

; Dantas, Maiko Roberto Tavares

; Santos, Romário Parente dos

; Moreira, Samara Sandy Jeronimo

; Pereira, Ana Glória

; Oliveira, Moacir Franco de

; Comizzoli, Pierre

; Silva, Alexandre Rodrigues

Animal Reproduction

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2023, Volume 20 N. 4 elocation e20230113

Abstract: En | Text: En | PDF: En

Abstract The objectives of the study were to (1) describe the kinematic parameters of spermatozoa (2) compare methods of evaluating sperm viability (3) validate assays of functionality and integrity of the sperm membrane and (4) evaluate possible changes between spermatozoa from the epididymis and the vas deferens of the greater rhea. Semen samples were recovered from 7 adult individuals. Sperm motility was characterized by adjusting the set-up for Computer-assisted semen analysis (CASA) to that new species. For sperm viability evaluation, smears of bromophenol blue and eosin-nigrosine dyes were used. Five solutions of different osmolarities were then tested for the hypoosmotic swelling test (HOST). The combination of fluorescent probes (propidium iodide - IP and Hoechst 33342) was also used to assess plasma membrane integrity. Data were presented as mean ± SEM. Rhea spermatozoa from the vas deferens had an overall motility of 14.6 ± 2.5%. The bromophenol blue staining technique revealed that 64.6 ± 5.2% sperm were viable, while that proportion was 72.1 ± 2.5% using eosin-nigrosine. An average of 77.6 ± 4.8% of spermatozoa reacted to the HOST with distilled water at 0 mOsm/l. Fluorescent probes indicated that 65.3 ± 2.6% of spermatozoa had intact membranes. Interestingly, no statistical differences were observed between the parameters analyzed in the epididymal spermatozoa and the vas deferens. These new assays set reference values that can now be used to further exploration of sperm handling conditions and freezing protocols in rheas.

https://doi.org/10.1590/1984-3143-ar2023-0113

14.

Differentially methylated regions identified in bovine embryos are not observed in adulthood
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Vargas, Luna Nascimento

; Nochi, Allice Rodrigues Ferreira

; Castro, Paloma Soares de

; Cunha, Andrielle Thainar Mendes

; Silva, Thainara Christie Ferreira

; Togawa, Roberto Coiti

; Silveira, Márcia Marques

; Caetano, Alexandre Rodrigues

; Franco, Maurício Machaim

Animal Reproduction

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2023, Volume 20 N. 1 elocation e20220076

Abstract: En | Text: En | PDF: En

Abstract The establishment of epigenetic marks during the reprogramming window is susceptible to environmental influences, and stimuli during this critical stage can cause altered DNA methylation in offspring. In a previous study, we found that low levels of sulphur and cobalt (low S/Co) in the diet offered to oocyte donors altered the DNA methylome of bovine embryos. However, due to the extensive epigenetic reprogramming that occurs during embryogenesis, we hypothesized that the different methylation regions (DMRs) identified in the blastocysts may not maintain in adulthood. Here, we aimed to characterize DMRs previously identified in embryos, in the blood and sperm of adult progenies of two groups of heifers (low S/Co and control). We used six bulls and characterized the DNA methylation levels of KDM2A, KDM5A, KMT2D, and DOT1L genes. Our results showed that all DMRs analysed in both groups and tissues were hypermethylated unlike that noticed in the embryonic methylome profiles. These results suggest that embryo DMRs were reprogrammed during the final stages of de novo methylation during embryogenesis or later in development. Therefore, due to the highly dynamic epigenetic state during early embryonic development, we suggest that is essential to validate the DMRs found in embryos in adult individuals.

https://doi.org/10.1590/1984-3143-ar2022-0076

15.

Agroforestry system improves soil carbon and nitrogen stocks in depth after land-use changes in the Brazilian semi-arid region
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Tonucci, Rafael Gonçalves

; Vogado, Renato Falconeres

; Silva, Rodrigo Dias

; Pompeu, Roberto Cláudio Fernandes Franco

; Oda-Souza, Melissa

; Souza, Henrique Antunes de

Revista Brasileira de Ciência do Solo

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2023, Volume 47 elocation e0220124

Abstract: En | Text: En | PDF: En

ABSTRACT Agroforestry systems have the potential to increase soil organic matter, with effects on soil carbon and nitrogen contents, but information on the application of these systems in semi-arid regions is still scarce. This study aimed to analyze soil carbon and nitrogen stocks in the conversion of native forest from the Caatinga Biome into integrated agriculture systems in the Brazilian semi-arid region. We evaluated the following management systems in the Haplic Inceptisol (Cambissolo Háplico eutrófico): (1) Intercropping area, cultivated with corn and Massai grass; (2) Caatinga (natural vegetation); (3) AFS10: agroforestry system with native woody forest rows occupying 33 % and agriculture occupying 66 % of the total area; and (4) AFS20: agroforestry system presenting inverse proportions of AFS10. The agroforestry systems were intercropped with sorghum or millet, pigeon pea and Massai grass. We collected disturbed and undisturbed soil samples at the layers of 0.00-0.10; 0.10-0.20; 0.20-0.40, 0.40-0.60 and 0.60-1.00 m for analysis of carbon (SOC), nitrogen (N), soil bulk density, and calculation of SOC and N stocks and C/N ratio, two years after the conversion of natural vegetation to the agricultural area (intercropping) and agroforestry system (AFS10 and AFS20). We applied principal component and cluster analysis to explore the data, and confidence interval to compare the means of accumulated SOC and N stocks up to 1 m soil depth. No differences exist for the properties analysed in superficial layers (0.00-0.10 and 0.10-0.20 m), regardless of land-use systems. AFS20 increase the SOC content and, consequently, SOC stock, in subsurface layers; on the other hand, intercropping increases N content and N stock. AFS20 presented higher accumulated SOC stocks up to 1.00 m (114.97 Mg ha-1). Agroforestry systems management is an alternative for increasing carbon sequestration under the conversion from Caatinga to agricultural areas.

https://doi.org/10.36783/18069657rbcs20220124

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