Purpose To evaluate the clinical outcome of a cohort of localized prostate cancer patients treate with 125-I permanent brachytherapy at the São José Hospital – CHLC, Lisbon. Materials and Methods A retrospective analysis was carried out on 429 patients with low and intermediate-risk of prostate adenocarcinoma, according to the recommendations of the EORTC, who underwent 125I brachytherapies in intraoperative dosimetry “real-time” system between September 2003 and September 2013. Results The mean follow-up was 71.98 months. Biochemical relapse of disease by rising PSA (Phoenix criterion) was observed in 18 patients (4.2%). Through the application of Kaplan-Meier survival curves in this sample, the rate of survival at 6 years without biochemical relapse was higher than 95%. By Iog rank test comparing biochemical relapse with initial PSA (15-10 and <10) and Gleason values (7 and <7), there was no statistical difference (P=0.830) of the initial PSA in the probability of developing biochemical relapse. In relation to Gleason score, it was noted a statistical difference (P<0.05), demonstrating that patients with Gleason 7 are more likely to develop biochemical relapse. Conclusions Brachytherapy as monotherapy is at present an effective choice in the treatment of localized prostate adenocarcinoma. Biochemical relapses are minimal. The initial PSA showed no statistically difference in the rate of relapses, unlike the value Gleason, where it was demonstrated that patients with Gleason 7 have a higher probability of biochemical relapse. Cases with PSA bounce should be controlled before starting a salvage treatment.

Poly (3-hydroxybutyrate) (PHB) is an important material used in the field of medicine. However in common conditions, PHB has some disadvantages. It is very brittle and slightly hydrophobic polymer. This somewhat limit its applications. Radiation can be used to improve its chemical properties. In the present study, the substrate, modified by radiation-induced graft copolymerization with vinyl acetate (VAc), was characterized using FTIR (Fourier Transform Infra-red) and Raman spectroscopy. FTIR spectroscopy did not reveal any significant bands but Raman spectroscopy revealed the formation of new bands that characterize the new material.

El poli (3-hidroxibutirato) (PHB) es un material importante de aplicación en el campo biomédico. Sin embargo, en condiciones comunes, se presenta con algunas desventajas que limitan su aplicación, como son su fragilidad y su moderada hidrofobicidad. Debido a esto, su campo de aplicaciones se encuentra limitado. Las radiaciones se pueden utilizar para transformar químicamente este sustrato y mejorar sus propiedades. En este estudio, el PHB modificado con el acetato de vinilo (VAc) por medio de una copolimerización por injerto radio-inducido, fue caracterizado utilizando espectroscopías FTIR y Raman. El análisis por FTIR no reveló ninguna banda característica que diferenciara al copolímero por injerto de los homopolímeros que lo forman, pero la espectroscopía Raman reveló la formación de nuevas bandas que caracterizan al nuevo material.

Dental professionals suffer a high incidence of problems related to their locomotive apparatus which, in certain cases, can limit their working performance. There are multiple and controversial explanations regarding the mechanisms and risk factors associated to these disorders. We also analyze the most important preventive measures.

Los profesionales de la Odontoestomatología sufren una incidencia alta de problemas en el aparato locomotor que, en ocasiones, pueden limitar su rendimiento laboral. Existen múltiples controversias relativas a los mecanismos y factores de riesgo implicados en estas molestias. Se analizan, además, las principales formas de prevención.