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Objective: Update the results of the BIOBADASAR registry on safety, duration and causes of treatment interruption after 8 years of follow-up. Methods: BIOBADASAR is a safety record of biological therapies established by the Argentine Society of Rheumatology. The description of BIOBADASAR 3.0 is presented, a cohort of 53 centers in Argentina followed prospectively from August 2010 to January 2018. Results: 4656 patients were registered, 6234 treatments [3765 cases (therapy with biologicals) and 2469 controls (non-biological therapy)]. Treatment was interrupted in 44.6% in cases vs. 27.9% in controls. Main cause of discontinuation was due to inefficiency (40% cases vs. 32% controls). There were 3154 adverse events (2230 in cases vs. 924 in controls), of which 13.6% were tombs (9.8% in cases and 3.7% in controls). The most frequent adverse event (AE) in both groups were infections (43.56% in cases vs. 34.31% in controls, RR: 3.42, 95% CI: 3.02-3.88), and the upper airway pathways (14.5%). Neoplasms were published in 78 cases versus 45 controls (RR: 1.98, 95% CI: 1.37-2.86). Conclusions: In this article, there are no different trends regarding safety, duration and causes of interruption of treatment compared to previous reports. Infections were the main causes of treatment discontinuation. The advent of new biological agents and the need for control over long-term security, strengthens the use of this type of registration.

Objetivo: Actualizar los resultados del registro BIOBADASAR sobre seguridad, duración y causas de interrupción del tratamiento luego de 8 años de seguimiento. Métodos: BIOBADASAR es un registro de seguridad de terapias biológicas establecido por la Sociedad Argentina de Reumatología. Se presenta la descripción de BIOBADASAR 3.0, una cohorte compuesta por 53 centros de Argentina seguidos prospectivamente desde agosto de 2010 hasta enero de 2018. Resultados: Se registraron 4656 pacientes, 6234 tratamientos [3765 casos (terapia con biológicos) y 2469 controles (terapia no biológicos)]. Se interrumpió el tratamiento en el 44,6% en los casos vs. 27,9% en los controles. Causa principal de discontinuación fue por ineficacia (40% casos vs. 32% controles). Se presentaron 3154 eventos adversos (2230 en casos vs. 924 en controles), de los cuales el 13,6% fueron graves (9,8% en casos y 3,7% en controles). El evento adverso (EA) más frecuente en ambos grupos fueron las infecciones (43,56% en casos vs. 34,31% en los controles, RR: 3,42; IC 95%: 3,02-3,88), y de ellas las de vías aéreas superiores (14,5%). Las neoplasias se presentaron en 78 casos vs. 45 en controles (RR: 1,98; IC 95%: 1,37-2,86). Conclusiones: En este sexto reporte no se observan tendencias diferentes sobre seguridad, duración y causas de interrupción del tratamiento respecto a informes previos. Las infecciones fueron el principal EA y la ineficacia, seguido por EA y la pérdida de pacientes las principales causas de suspensión del tratamiento. El advenimiento de nuevos agentes biológicos y la necesidad de control en seguridad a largo plazo, fortalece el uso de este tipo de registro.

197 downloads

Operational management of the cane infield wagon: Analysis of the cost of repair and maintenance
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Galvão, Cezario B.

; Garcia, Angel P.

; Albiero, Daneil

; Ribeiro, Admilson Í.

; Banchi, Ângelo D.

Revista Brasileira de Engenharia Agrícola e Ambiental

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mar 2018, Volume 22 N. 3 Pages 218 - 222

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Na colheita mecanizada de cana-de-açúcar é utilizada uma colhedora autopropelida em conjunto com uma máquina agrícola denominada de transbordo, que tem a função de transportar o produto colhido. Os custos com o corte, carregamento e transporte variam entre 30 e 60% dos custos de produção da cana-de-açúcar. Dentre os custos operacionais de máquinas agrícolas, o custo de reparo e manutenção (CRM) possui relevância, sendo assim, objetivou-se neste trabalho determinar os parâmetros do modelo matemático do CRM em função da vida (horas de uso) para o transbordo, utilizando o método da American Society of Agricultural and Biological Engineers (ASABE). Estes modelos de CRM foram obtidos para dois conjuntos de transbordos de fabricantes diferentes e seus dados despendidos ao longo de até 12 anos. O modelo foi ajustado e posteriormente validado utilizando métodos de estatística descritiva. As equações ajustadas do CRM foram diferentes para cada conjunto de transbordo analisado, sendo portanto, uma ferramenta importante na gestão da mecanização nas usinas pois fornece elementos que podem subsidiar as tomadas de decisão dos gestores na aquisição e gerenciamento de equipamentos agrícolas.

ABSTRACT In the mechanical harvesting of sugarcane, a self-propelled harvester is used in conjunction with an agricultural implement named infield wagon, which has the function of storing and transporting the harvested product. Much of the cost of sugarcane production comes from this operation (30 to 60%). Among the operational costs of agricultural machinery, the cost of repair and maintenance (CRM) is relevant. Therefore, the objective of this study was to determine the parameters of the CRM mathematical model based on the life (hours of use) for the infield wagon, using the method of the American Society of Agricultural and Biological Engineers (ASABE). These CRM models were obtained for two sets of infield wagon from different manufacturers and their costs over up to 12 years. The model was adjusted and then validated using descriptive statistics methods. Fitted CRM equations were different for each analyzed set of infield wagon and, therefore, are a valuable tool in the management of mechanization in sugarcane mills as it provides elements that can support decision-making of managers in the acquisition and management of agricultural implements.

https://doi.org/10.1590/1807-1929/agriambi.v22n3p218-222 1124 downloads

Aplicación de las pruebas electrofisiológicas en el estudio de enfermedades neurológicas con afectación visual
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Rodriguez-Mena, D.

; Almarcegui, C.

; Dolz, I.

; Pablo, L.E.

; Garcia-Martin, E.

Archivos de la Sociedad Española de Oftalmología

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oct 2012, Volume 87 N. 10 Pages 311 - 314

Abstract: Es | Text: Es | PDF: Es

https://doi.org/10.1016/j.oftal.2012.09.001 2099 downloads

The diversity, extracellular enzymatic activities and photoprotective compounds of yeasts isolated in Antarctica
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Vaz, Aline B. M

; Rosa, Luiz H

; Vieira, Mariana L. A

; Garcia, Virginia de

; Brandão, Luciana R

; Teixeira, Lia C. R. S

; Moliné, Martin

; Libkind, Diego

; van Broock, Maria

; Rosa, Carlos A

Brazilian Journal of Microbiology

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sep 2011, Volume 42 N. 3 Pages 937 - 947

Abstract: En | Text: En | PDF: En

The diversity of yeasts collected from different sites in Antarctica (Admiralty Bay, King George Island and Port Foster Bay and Deception Island) and their ability to produce extracellular enzymes and mycosporines were studied. Samples were collected during the austral summer season, between November 2006 and January 2007, from the rhizosphere of Deschampsia antarctica, ornithogenic (penguin guano) soil, soil, marine and lake sediments, marine water and freshwater from lakes. A total of 89 isolates belonging to the following genera were recovered: Bensingtonia, Candida, Cryptococcus, Debaryomyces, Dioszegia, Exophiala, Filobasidium, Issatchenkia (Pichia), Kodamaea, Leucosporidium, Leucosporidiella, Metschnikowia, Nadsonia, Pichia, Rhodotorula, and Sporidiobolus, and the yeast-like fungi Aureobasidium, Leuconeurospora and Microglossum. Cryptococcus victoriae was the most frequently identified species. Several species isolated in our study have been previously reported to be Antarctic psychophilic yeasts, including Cr. antarcticus, Cr. victoriae, Dioszegia hungarica and Leucosporidium scottii. The cosmopolitan yeast species A. pullulans, C. zeylanoides, D. hansenii, I. orientalis, K. ohmeri, P. guilliermondii, Rh. mucilaginosa, and S. salmonicolor were also isolated. Five possible new species were identified. Sixty percent of the yeasts had at least one detectable extracellular enzymatic activity. Cryptococcus antarcticus, D. aurantiaca, D. crocea, D. hungarica, Dioszegia sp., E. xenobiotica, Rh. glaciales, Rh. laryngis, Microglossum sp. 1 and Microglossum sp. 2 produced mycosporines. Of the yeast isolates, 41.7% produced pigments and/or mycosporines and could be considered adapted to survive in Antarctica. Most of the yeasts had extracellular enzymatic activities at 4ºC and 20ºC, indicating that they could be metabolically active in the sampled substrates.

6961 downloads

Reduction of splice loss between dissimilar fibers by tapering and fattening
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Martínez-Rios, A.

; Torres-Gómez, I.

; Monzon-Hernandez, D.

; Barbosa-Garcia, O.

; Duran-Ramirez, V.M.

Revista mexicana de física

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feb 2010, Volume 56 N. 1 Pages 80 - 84

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

A method for reducing splice loss between dissimilar optical fibers is presented. The fibers are first spliced by using a standard fusion splicing procedure, and then the fiber with the greater core is tapered before the splice point, while the fiber with the smaller core is fattened. By using this technique we have consistently obtained splice loss values of 0.13 dB between a DS/SMF and an SMF28 fiber, and 0.09 dB between a 980HP fiber and an SMF28 fiber.

Presentamos un método para reducir las perdidas en empalmes entre fibras ópticas con diferentes características. Las fibras son unidas usando un procedimiento de fusión estándar, para luego reducir el diámetro de la fibra con el núcleo de mayor tamaño antes del punto de unión, mientras que la fibra con el diámetro de núcleo menor es ensanchada. Mediante el uso de esta técnica hemos obtenido de manera consistente perdidas de 0.13 dB en un empalme entre una fibra DS/SMF y una fibra SMF28, y perdidas de 0.09 dB en un empalme entre una fibra 980HP y una fibra SMF28.

1659 downloads

Formación de pelos en el alga agarófita gracilaria chilensis(Gracilariales, Rhodophyta)
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Garcia, Maximiliano D.

; Miravalles, Alicia B.

; Leonardi, Patricia I.

Darwiniana, nueva serie

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jul 2007, Volume 45 N. 1 Pages 7 - 12

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Gracilaria chilensis (Gracilariales) is an agarophyte red alga belonging to class Florideophyceae. The purpose of this study was to describe the hair formation mechanism. Thalli were maintained in culture with enriched seawater under controlled conditions of light and temperature. Hair formation was induced on portions of thalli growing in a nitrogen-free culture medium. Light (bright field) microscopy, transmission and scanning electron microscopy techniques were used. Hairs develop from large ovoid hair-producing cortical cells (HPCs). These cells are multinucleate, contain small plastids, and abundant endoplasmic reticulum apically positioned. Each hair begins as a protuberance initially covered by a multilaminar wall, this is, in turn, ruptured along with the thallus wall as the protuberance elongates. Hairs are formed when cytokinesis occurs at the base of the protuberance. An asymmetric pit plug is formed between the hair's base and the HPC. Hairs are unicellular, with a vacuole and numerous nuclei. They have an active growth, and leave a concentric scar on the wall after detachment. Hair formation mechanism in G. chilensis is also compared with that observed in other species of the same class. In nitrogen-free culture media, the thallus of G. chilensis grows less, but the number of hairs increases.

Gracilaria chilensis es un alga roja agarófita perteneciente a la clase Florideophyceae. En este estudio se describe la formación de pelos en talos mantenidos en cultivo en agua de mar enriquecida, bajo condiciones controladas de luz y temperatura. La inducción de los pelos fue realizada colocando porciones de talos en un medio de cultivo carente de compuestos nitrogenados. Se emplearon técnicas de microscopía óptica y electrónica de transmisión y barrido. Los pelos se desarrollan a partir de células corticales ovoides grandes. Estas células formadoras de pelos (CFPs) son multinucleadas, poseen pequeños plástidos y una abundante red de retículo endoplasmático de disposición apical. La formación de los pelos comienza con el desarrollo de una protuberancia, inicialmente cubierta por una pared multilaminar, la cual se rompe junto con la pared del talo, con la consecuente elongación de la protuberancia. El pelo queda establecido cuando se produce una citocinesis en la base de la protuberancia, formándose una conexión citoplasmática obliterada o "pit plug" asimétrica entre la base del pelo y la CFP. Los pelos son unicelulares, poseen una vacuola y numerosos núcleos. Tienen un crecimiento activo dejando, al caerse, una cicatriz de forma concéntrica en la pared. Se compara este proceso con el descrito en otras especies de la clase. En medios de cultivo carentes de nitrógeno, el crecimiento del talo de G. chilensis fue menor, aumentando el número de pelos.

950 downloads

The nuclear matter effects in pi0 photoproduction at high energies
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Rodrigues, T. E.

; Arruda-Neto, J. D. T.

; Mesa, J.

; Garcia, C.

; Shtejer, K.

; Dale, D.

; Nakagawa, I.

Brazilian Journal of Physics

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dec 2006, Volume 36 N. 4b Pages 1366 - 1370

Abstract: En | Text: En | PDF: En

The in-medium influence on pi0 photoproduction from spin zero nuclei is carefully studied in the GeV range using a straightforward Monte Carlo analysis. The calculation takes into account the relativistic nuclear recoil for coherent mechanisms (electromagnetic and nuclear amplitudes) plus a time dependent multi-collisional intranuclear cascade approach (MCMC) to describe the transport properties of mesons produced in the surroundings of the nucleon. A detailed analysis of the meson energy spectra for the photoproduction on 12C at 5.5 GeV indicates that both the Coulomb and nuclear coherent events are associated with a small energy transfer to the nucleus ($\lesssim$ 5 MeV), while the contribution of the nuclear incoherent mechanism is vanishing small within this kinematical range. The angular distributions are dominated by the Primakoff peak at extreme forward angles, with the nuclear incoherent process being the most important contribution above $\theta_{\pi^{0}}\gtrsim2^{0}$. Such consistent Monte Carlo approach provides a suitable method to clean up nuclear backgrounds in some recent high precision experiments, such as the PrimEx experiment at the Jefferson Laboratory Facility.

1069 downloads

Potencial antimicrobiano e alelopático das amidas isoladas do extrato das raízes de Ottonia martiana Miq.
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Cunico, Miriam Machado

; Dias, Josiane G.

; Miguel, Marilis D.

; Miguel, Obdulio Gomes

; Auer, Celso Garcia

; Côcco, Lílian C.

; Lopes, André R.

; Yamamoto, Carlos I.

; Delle Monache, Franco

Química Nova

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jul 2006, Volume 29 N. 4 Pages 746 - 749

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Two amides, piperovatine and isopiperlonguminine, were isolated from the roots of Ottonia martiana Miq., a herbaceous shrub commonly used in folk medicine in the treatment of toothache. The crude extract (CE) and isolated compounds were submitted to bioautography and allelopathic assay. The bioautograms allowed the detection of compounds with antibacterial activity and the identification of the bioactive substance piperovatine. The CE and amides exhibited an allelopathic effect on Lactuca sativa (lettuce) seedling growth but did not affect the seeds' germinability.

2381 downloads Cited 2 times in SciELO

Materiais cerâmicos ferroelétricos como hospedeiros para íons laser ativos: características estruturais, microestruturais e espectroscópicas
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Camargo, A. S. S. de

; Botero, É. R.

; Nunes, L. A. O.

; Lente, M. H.

; Santos, I. A.

; Andreeta, É. R. M.

; Garcia, D.

; Eiras, J. A.

Cerâmica

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dec 2004, Volume 50 N. 316 Pages 368 - 377

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Cerâmicas ferroelétricas transparentes de titanato zirconato de chumbo modificado com lantânio (PLZT, com La/Zr/Ti=9/65/35) e dopadas com íons terras raras (TR = Nd3+, Er3+, Yb3+, Tm3+ e Ho3+) foram preparadas por prensagem uniaxial a quente com o objetivo de investigar a sua qualificação como materiais laser ativos. Com este propósito foram feitas caracterizações estruturais, microestruturais, elétricas e espectroscópicas. Para a dopagem com 1% em peso de óxido TR2O3, verificou-se uma forte influência do tipo de íon terra rara nas características ferroelétricas e óticas do material hospedeiro. Observou-se ainda que a incorporação de Nd3+ nos sítios de Pb2+/La3+ reduziu a temperatura de transição ferro-paraelétrica e favoreceu significativamente a transparência dos corpos cerâmicos. Medidas de espectroscopia ótica revelaram a potencialidade do PLZT: Nd3+ como um meio ativo para a construção de lasers bombeados por lasers de diodo, na região do infravermelho próximo. Os sistemas PLZT:Er3+ e PLZT:Tm3+ poderão também se tornar materiais interessantes para esse fim.

In this work, transparent ferroelectric ceramics of lanthanum modified lead zirconate titanate (PLZT, with La/Zr/Ti=9/65/35), doped with rare-earth ions (RE = Nd3+, Er3+, Yb3+ Tm3+ and Ho3+), were processed by hot uniaxial pressing aiming the investigation of their potentiality as near-infrared laser active media. Their structural, microstructural, electric and spectroscopic characterizations were performed. For 1.0 wt.% RE2O3 doping, a strong influence of the rare-earth type was verified in the PLZT ferroelectric and optical characteristics. It was also observed that the Nd3+ substitution for Pb2+/La3+ reduces the ferro-paraelectric phase transition temperature and favors the transparency of the ceramic bodies. Spectroscopic analysis indicates that PLZT:Nd3+ is a potential diode-pumped laser active media in the near infrared region, and with some improvements, PLZT:Er3+ and PLZT:Tm3+ might also become so .

2859 downloads

10.

Perda auditiva sensorioneural no lúpus eritematoso sistêmico: relato de três casos
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Cecatto, Suzana B.

; Garcia, Roberta I. D.

; Costa, Kátia S.

; Anti, Sônia M. A.

; Longone, Erika

; Rapoport, Priscila B.

Revista Brasileira de Otorrinolaringologia

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jun 2004, Volume 70 N. 3 Pages 398 - 403

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

INTRODUÇÃO: O Lúpus Eritematoso Sistêmico (LES) é uma doença sistêmica do tecido conectivo, de etiologia desconhecida, provavelmente multifatorial. Acomete principalmente o sexo feminino podendo afetar múltiplos órgãos, dentre eles o sistema auditivo. A orelha interna pode ser lesada por diversos mecanismos auto-imunes, sendo a manifestação mais freqüente a disacusia sensorioneural flutuante, geralmente bilateral, rapidamente progressiva e com boa responsividade a imunossupressores. OBJETIVO: O objetivo deste trabalho é relatar três casos de disacusia de etiologia auto-imune, enfocando formas de acometimento e manifestações clínicas, bem como correlacionando o efeito ototóxico da cloroquina - droga empregada no controle do LES - com a perda auditiva. CONCLUSÃO: As perdas auditivas sensorioneurais súbitas, rapidamente progressivas ou flutuantes, podem ocorrer em pacientes com doença auto-imune e devem ser sempre lembradas nos casos de disacusia sem causa aparente.

INTRODUCTION: The Systemic Lupus Erythematosus (SLE) is a systemic disease of the connective tissue, with unknown etiology, probably associated to multiple events. It is a multiple organs disease that affects mainly women. The inner ear can be damaged by several immunopathogenic mechanisms, and the most common symptom is a progressive sensorineural hearing loss, generally bilateral, with good response to immunossupression. AIM: The purpose of this article is to report three cases of women suffering from SLE and hearing loss and to establish a link between the autoimmune and the vascular mechanisms of the disease, also focusing attention on the ototoxicity due to chloroquine applied during the treatment of SLE. CONCLUSION: Sudden or fluctuant sensorineural hearing loss may affect patients with autoimmune disease, so it must always be taken into account when dealing with patients suffering from hearing loss without any apparent cause.

9856 downloads

11.

Disacusia sensorioneural autoimune em criança: relato de caso
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Costa, Kátia S.

; Garcia, Roberta I. D.

; Cecatto, Suzana B.

; Rapoport, Priscila B.

; Mendonça, Renata

Revista Brasileira de Otorrinolaringologia

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jun 2004, Volume 70 N. 3 Pages 394 - 397

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

A disacusia sensorioneural autoimune é reconhecida como uma das poucas causas reversíveis de perda auditiva sensorioneural. Acomete na grande maioria das vezes mulheres entre 30 e 40 anos, sendo extremamente raro em crianças. O diagnóstico baseia-se no quadro clínico, testes laboratoriais, bem como resposta satisfatória a corticoterapia. O exame audiológico não apresenta características típicas. Neste trabalho os autores descrevem o caso de um menino de sete anos com diagnóstico de disacusia sensorioneural autoimune.

The autoimmune inner ear disease is a rare case of reversible sensorioneural hearing loss. The typical afflicted patient is the middle-aged woman, and it is very rare in the pediatric population. The diagnosis is based on disease manifestations, laboratory exams and a positive corticosteroid response. The audiometric evaluation does not revel typical characteristics. The authors report a case of autoimmune sensorioneural hearing loss in a seven-year-old child.

6199 downloads

12.

Tuberculose e blastomicose laríngeas: relato de três casos e revisão de literatura
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Garcia, Roberta I. D.

; Cecatto, Suzana B.

; Mendonça, Renata R.

; Barcelos, Carlos E. M.

; Santos, Rodrigo O.

; Rapoport, Priscila B.

Revista Brasileira de Otorrinolaringologia

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apr 2004, Volume 70 N. 2 Pages 255 - 259

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

As doenças granulomatosas da laringe apresentam quadros polimórficos de difícil diagnóstico pelo exame clínico. São patologias que apresentam evolução favorável se o tratamento efetivo for introduzido precocemente, evitando complicações. Muitas vezes, a primeira manifestação destas patologias dá-se a nível da laringe, portanto devem ser lembradas no diagnóstico diferencial de doenças inflamatórias. Relatamos o caso de três pacientes que procuraram nosso Serviço com queixa de disfonia, sem alteração ao exame físico geral, sendo diagnosticada após a investigação tuberculose e blastomicose laríngeas.

The granulomatosis diseases of the larynx have different clinical manifestations, which difficult the clinical diagnosis. When the treatment is early introduced, the result is satisfactory. The first manifestation of granulomatosis diseases can occur in larynx, and it always has to be remembered among laryngeal inflammatory diseases. We reported three cases were symptom was hoarseness, and after investigation the diagnosis was tuberculosis and blastomycosis of the larynx. The evaluation and management are discussed.

13450 downloads

13.

Síndrome de Guillain-Barré como complicação de amigdalite aguda
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Cecatto, Suzana B.

; Garcia, Roberta I. D.

; Costa, Kátia S.

; Novais, Roberta A B.

; Yoshimura, Ricardo

; Rapoport, Priscila B.

Revista Brasileira de Otorrinolaringologia

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aug 2003, Volume 69 N. 4 Pages 566 - 569

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

A Síndrome de Guillain-Barré é uma polirradiculoneuropatia aguda ou subaguda e geralmente ocorre após uma doença infecciosa ou algum procedimento cirúrgico. A patogênese não é bem conhecida, mas provavelmente apresenta uma base imunológica. O objetivo deste trabalho é relatar um caso de amigdalite aguda de má evolução complicada com a Síndrome de Guillain-Barré. Os autores salientam a raridade do caso, a concomitância do início da infecção aguda com a própria Síndrome e a evolução rápida para a falência respiratória que normalmente ocorre somente em 20% dos casos. O tratamento foi a imunoterapia com rápida recuperação do paciente.

The Guillain-Barre Syndrome is an acute or subacute polyradiculoneuropathy that sometimes follows infective illness or surgical procedures. The precise mechanism is unclear, but the disorder probably has an immunological basis. The authors report a case in which acute tonsillitis was complicated with Guillain-Barre Syndrome. We emphasize the simultaneousness of the acute disease and the syndrome, with fast progression to respiratory arrest occuring only in 20% of cases. The treatment was the immunotherapy with prompt recovering of the patient.

29161 downloads

14.

Síndrome de Rendu-Osler-Weber: tratamento clínico e cirúrgico
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Garcia, Roberta I. D.

; Cecatto, Suzana B.

; Costa, Kátia S.

; A. Jr., Fernando Veiga

; Uvo, Ivan P.

; Rapoport, Priscila Bogar

Revista Brasileira de Otorrinolaringologia

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aug 2003, Volume 69 N. 4 Pages 577 - 580

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Teleangiectasia Hemorrágica Hereditária (Síndrome de Rendu-Osler-Weber) consiste de uma rara displasia fibrovascular sistêmica, de transmissão autossômica dominante, com incidência de 1-2/100000, afetando vasos sangüíneos da pele, mucosas, pulmões e trato gastrointestinal. É reconhecida pela tríade clássica de teleangiectasias em face, mãos e cavidade oral, epistaxes recorrentes e histórico familiar. Em 90% dos casos, a epistaxe recorrente é o principal sintoma, porém a doença pode afetar qualquer parte do organismo. O tratamento é paliativo, sendo ainda controverso. Neste estudo relatamos três pacientes portadores da doença, enfocando aspectos clínicos e tratamento.

Hereditary Haemorrhagic Telangiectasia (Rendu-Osler-Weber disease) is a rare disease with and incidence of 1-2/100000, affecting blood vessels of the skin, mucous membrane, lungs and gastrointestinal tract. It is recognized as a classic triad of teleangiectasia in face, hands and cavity; recurrent epistaxe and family occurrence. We reported three patients with Rendu-Osler-Weber disease and discussed about clinical manifestations and treatment.

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Cerâmicas ferroelétricas transparentes de PLZT e PLMN-PT: processamento e propriedades
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Santos, I. A.

; Zanin, A. L.

; Lente, M. H.

; Assis, S. B.

; Favaretto, R.

; Garcia, D.

; Eiras, J. A.

Cerâmica

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apr 2003, Volume 49 N. 310 Pages 92 - 98

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Cerâmicas ferroelétricas transparentes têm sido largamente empregadas em dispositivos ópticos e eletro-ópticos. Neste trabalho apresentamos recentes progressos alcançados pelo GCFerr/DF-UFSCar na obtenção de cerâmicas ferroelétricas transparentes, obtidas por prensagem uniaxial a quente. São apresentados resultados de caracterizações microestrutural, estrutural, óptica, dielétrica, piroelétrica, eletro-óptica, eletrostrictiva e ferroelétrica, em cerâmicas de titanato zirconato de chumbo modificado com lantânio (PLZT) e niobato de magnésio e chumbo - titanato de chumbo modificado com lantânio (PLMN-PT). Os resultados obtidos revelaram uma microestrutura homogênea, altos valores de densidade e ausência de fases segregadas para as cerâmicas de ambas composições. Conseqüentemente, altos valores de transmitância foram observados para as regiões visível e infravermelho próximo. As medidas elétricas também apresentaram excelentes resultados, quando comparados à literatura, demonstrando a alta qualidade das amostras obtidas.

Transparent ferroelectric ceramics have been extensively employed in optical and electrooptical devices. The recent progresses achieved by the GCFerr/DF - UFSCar in the production of the transparent ferroelectric ceramics, through uniaxial hot-pressing technique, are presented. The physical property characterization, as microstructural, structural, optical, dielectrical, pyroelectric, electro-optical, electrostrictive and ferroelectric are reported for lanthanum modified lead zirconate titanate (PLZT) and lanthanum modified lead magnesium niobate - lead titanate (PLMN-PT) ceramics. The results revealed a homogeneous microstructure, high densities and absence of second phases for the ceramics of both compositions. Consequently, high optical transmittance was found in the visible and infrared range. The electrical measurements also presented excellent results when compared to those reported in the literature confirming the high quality of the samples.

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