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ABSTRACT Objective: To evaluate autoinflammatory diseases (AID) according to age at diagnosis and sex, and response to therapy in a large population. Methods: This is a cross-sectional observational study of a Latin American registry using a designed web system for data storage, collected between 2015 and 2018. Any altered findings during follow-up were recorded. The forms were translated into Portuguese and Spanish, including demographic, clinical, laboratory, genetic and treatment characteristics. Results: We included 152 patients, 51.3% male and 75% Caucasian. The median age at disease onset was 2.1 years (0–15.6 years) and median age at diagnosis 6.9 years (0–21.9 years); 111 (73%) were children (0–9 years old), and 41 (27%) were adolescents and young adults (AYA) (10–21 years old). Periodic fever, aphthous stomatitis, pharyngitis, and adenitis syndrome (PFAPA) occurred in 46/152 (30%), chronic non-bacterial osteomyelitis (CNO) in 32/152 (21%), and familial Mediterranean fever (FMF) in 24/152 (15.7%). PFAPA was significantly higher in young children than in AYA (38.7% vs. 7.3%, p<0.001), while CNO were lower (13.5% vs. 41.5%, p<0.001). The frequency of females was significantly higher in CNO (28.4% vs. 14.1%, p=0.031) and lower in FMF (8.1% vs. 23.1%, p=0.011). The most used drugs were glucocorticoids, non-steroidal anti-inflammatory drugs (NSAID), and colchicine. Glucocorticoids and colchicine treatment were used in all AID with good to moderate response. However, cryopyrin-associated periodic syndromes (CAPS) seemed unresponsive to glucocorticoids. NSAIDs and methotrexate were the main medications used to treat CNO. Conclusions: Differences among AID patients were observed in the LA population regarding sex and age at disease diagnosis.

RESUMO Objetivo: Avaliar as doenças autoinflamatórias (DAI) de acordo com sexo e idade no momento do diagnóstico e a resposta terapêutica em uma grande população. Métodos: Este é um estudo observacional transversal de um registro latino-americano que usou um sistema de dados coletados entre 2015 e 2018. Quaisquer achados alterados ao longo do acompanhamento foram registrados. Os formulários foram traduzidos para os idiomas português e espanhol, incluindo características demográficas, clínicas, laboratoriais, genéticas e de tratamento. Resultados: Incluímos 152 pacientes, sendo 51,3% do sexo masculino e 75% da raça branca. A média de idade de início da doença foi de 2,1 anos (0–15,6 anos) e a média de idade de diagnóstico 6,9 anos (0–21,9 anos); 111 (73%) eram crianças (0–9 anos) e 41 (27%) adolescentes/adultos jovens (10–21 anos). A síndrome de febre periódica, estomatite aftosa, faringite e adenite (PFAPA) ocorreu em 46/152 (30%), osteomielite não bacteriana crônica (CNO) em 32/152 (21%) e febre familiar do Mediterrâneo (FMF) em 24/152 (15,7%). A PFAPA foi significativamente maior em crianças pequenas (38,7 vs. 7,3%, p<0,001), e a CNO, em adolescentes/adultos jovens (13,5 vs. 41,5%, p<0,001). A frequência do sexo feminino foi significativamente maior na CNO (28,4 vs. 14,1%, p=0,031) e menor na FMF (8,1 vs. 23,1%, p=0,011). Os medicamentos mais utilizados foram glicocorticoides, anti-inflamatórios não esteroidais (AINE) e colchicina. O tratamento com glicocorticoides e colchicina foi usado em todas as DAI com resposta boa a moderada. No entanto, as síndromes periódicas associadas à criopirina (CAPS) pareciam não responder aos glicocorticoides. AINE e metotrexato foram os principais medicamentos utilizados no tratamento da CNO. Conclusões: Diferenças de pacientes com DAI foram observadas na população latino-americana em pacientes agrupados por sexo e idade ao diagnóstico da doença.

https://doi.org/10.1590/1984-0462/2024/42/2022184

Development and characterization of bacterial cellulose membrane incorporated with Witch hazel extract
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Molin, Maria Luiza

; Segat, Bruna

; Garcia, Michele Cristina Formolo

; Pezzin, Ana Paula Testa

; Silveira, Márcia Luciane Lange

; Schneider, Andrea Lima dos Santos

Matéria (Rio de Janeiro)

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2023, Volume 28 N. 2 elocation e20230008

Abstract: En | Text: En | PDF: En

ABSTRACT Bacterial cellulose (BC) has stood out in the biomedical field for its biocompatibility, non-toxicity and high liquid absorption capacity. Thus, studies have been conducted aiming at the functionalization of BC with substances that add properties, such as anti-inflammatory and antimicrobial action. Hamamelis virginiana plant extract is known for its astringent, anti-inflammatory and antimicrobial properties. Thus, the present work aimed to incorporate aqueous (AE) and glycolic (GE) extracts of witch hazel in different concentrations to BC, aiming at its application as a curative. BC membranes incorporated with the extracts were characterized by thermogravimetric analysis (TGA), Fourier transforms infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and antimicrobial activity. The TGA results indicated a reduction in thermal stability and the appearance of a new stage of degradation in the samples that underwent incorporation. Furthermore, the FTIR showed the presence of aromatic compounds not found in the BC, corroborating the TGA. The micrographs revealed that the incorporation of the extracts resulted in the formation of a film on the surface of the membranes, covering the nanofibers. These results show that incorporating the aqueous and glycol extracts in the BC membrane was successful. However, despite the crude extracts’ antimicrobial potential, antimicrobial activity in the functionalized BC samples was not observed.

https://doi.org/10.1590/1517-7076-rmat-2023-0008

L-glutamine supplementation reduced morphological damage in the renal glomerulus of rats with Walker-256 tumor
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Lima, Kaio Ramon de Aguiar

; Lopes, Maria Luiza Diniz de Sousa

; Souza, Sara Raquel Garcia de

; Fracaro, Luciane

; Purificação, Natan Reyges Castro da

; Lima, Marília Fabiana de Oliveira

; Lins, Lucas Alexandre Araújo

; Lacchini, Silvia

; Araújo, Aurigena Antunes de

; Araújo Júnior, Raimundo Fernandes de

; Perles, Juliana Vanessa Colombo Martins

; Zanoni, Jacqueline Nelisis

; Clebis, Naianne Kelly

Acta Cirúrgica Brasileira

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2023, Volume 38 elocation e383923

Abstract: En | Text: En | PDF: En

ABSTRACT Purpose: To evaluate the effects of the experimental subcutaneous Walker-256 tumor and L-glutamine supplementation, an antioxidant, on the glomerular morphology of rats. Methods: Twenty Wistar rats were distributed into four groups (n = 5): control (C); control treated with 2% L-glutamine (CG); rats with Walker-256 tumor (WT); and rats with Walker-256 tumor treated with 2% L-glutamine (WTG). Renal histological samples were submitted to periodic acid-Schiff and Masson’s Trichrome staining to analyze glomerular density, morphometry of glomerular components and glomerulosclerosis; and to immunohistochemistry for fibroblast growth factor-2 (FGF-2). Results: WT showed 50% reduction in body mass gain and cachexia index > 10%, while WTG demonstrated reduction in cachexia (p < 0.05). WT revealed reduction of glomerular density, increase in the glomerular tuft area, mesangial area, matrix in the glomerular tuft, decrease in the urinary space and synechia, and consequently higher glomerulosclerosis (p < 0.05). L-glutamine supplementation in the WTG improved glomerular density, and reduced glomerular tuft area, urinary space, mesangial area, and glomerulosclerosis compared to WT(p < 0.05). WT showed higher collagen area and FGF-2 expression compared to C (p < 0.05). WTG presented lower collagen fibers and FGF-2 expression compared to WT (p < 0.05). Conclusions: L-glutamine supplementation reduced cachexia and was beneficial for glomerular morphology of the rats, as well as it reduced kidney damage and improved the remaining glomeruli morphology.

https://doi.org/10.1590/acb383923

Evaluation of the association between self-reported sleep bruxism and chronotype and sleep quality among dental students
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Araújo, Luíza Jordânia Serafim de

; Lima, Larissa Chaves Morais de

; Bernardino, Veruska Medeiros Martins

; Leal, Tiago Ribeiro

; Granja, Gélica Lima

; Dias, Ricardo Bernardo

; Serra-Negra, Junia Maria Cheib

; Neves, Érick Tássio Barbosa

; Paiva, Saul Martins

; Granville-Garcia, Ana Flávia

Cadernos Saúde Coletiva

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2023, Volume 31 N. 3 elocation e31030085

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT Background Sleep bruxism (BS) is defined as involuntary jaw movements characterized by grinding and clenching teeth. Objective To verify the association between chronotype, sleep quality, and self-reporting of BS in dental students. Method A cross-sectional study was conducted with 214 undergraduate dental students at a public university in northeast Brazil. The participants answered the Munich Chronotype Questionnaire for the identification of chronotype and another questionnaire regarding daily aspects to collect information about sleep quality, self-reported sleep bruxism, the use of sleeping pills, snoring, concentration during daily activities and energy upon waking. Results The prevalence of self-reported sleep bruxism was 11.0%. In the final model, the eveningness chronotype (OR = 23.00; 95% CI: 2.36-223.84, p = 0.007), habitual snoring (OR = 3.12; 95% CI: 1.31-7.39, p = 0.01) and low energy upon waking in the morning (OR = 2.37; 95% CI: 1.96-5.58, p = 0.040) were associated with self-reported sleep bruxism. Conclusion The evening chronotype, presence of snoring, and low energy when waking up in the morning influenced self-reporting of sleep bruxism among undergraduate dental students.

RESUMO Introdução O bruxismo do sono (BS) é definido como movimentos involuntários da mandíbula caracterizados por ranger e apertar os dentes. Objetivo Verificar se o cronotipo e a qualidade do sono estão associados ao autorrelato de BS em graduandos de Odontologia. Método Um estudo transversal com 214 estudantes de uma universidade pública do Nordeste do Brasil. Os participantes responderam ao Morningness-Eveningness Questionnaire para identificar os cronotipos e outro questionário sobre aspectos diários em que foram coletadas informações sobre qualidade do sono, autorrelato de bruxismo do sono, uso de pílulas para dormir, ronco, concentração nas atividades diárias, energia ao acordar. Resultados A prevalência de autorrelato do bruxismo do sono foi de 11,0%. No modelo final, o cronotipo noturno (OR = 23,00; 95% IC: 2.36-223.84, p = 0,007), o hábito de roncar (OR = 3,12; 95% IC: 1.31-7.39, p = 0,01) e o baixo nível de energia ao acordar pela manhã (OR = 2,37; 95% IC: 1.96-5.58, p = 0,04) estiveram associados com o autorrelato de BS. Conclusão O cronotipo noturno, a presença do ronco e a baixa energia ao se levantar pela manhã influenciaram o autorrelato de bruxismo do sono entre os estudantes de graduação em Odontologia.

https://doi.org/10.1590/1414-462x202331030085

Análise de efeito idade-período-coorte na mortalidade por doenças cerebrovasculares em Maceió e Florianópolis
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Lima, Fernanda Cristina da Silva de

; Martins, Wolney de Andrade

; Rosa, Maria Luiza Garcia

; Nunes, Samon Henrique

Cadernos Saúde Coletiva

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sep 2022, Volume 30 N. 3 Pages 309 - 318

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Introdução A doença cerebrovascular (DCBV) é a segunda principal causa de morte no mundo e no Brasil. Objetivo Avaliar as tendências da mortalidade por DCBV em duas cidades brasileiras (Maceió e Florianópolis) com diferenças socioeconômicas extremas, entre 1981 e 2015, estimando os efeitos idade, período e coorte. Método Estudo de séries temporais da mortalidade por DCBV em indivíduos com ≥ 40 anos, empregando a ferramenta Web tool. Resultados A mortalidade por DCBV diminuiu com o tempo, aumentou com a idade e foi menor para gerações mais novas. O efeito foi igual para ambos os sexos. Houve diminuição da mortalidade nas duas cidades, mas a diferença foi grande e a mortalidade continua alta em Maceió. Com base na amplitude dos efeitos estimados, foi possível verificar que o efeito de coorte foi o termo mais significativo para explicar a variabilidade temporal das taxas de mortalidade por DCBV no período. Conclusão A comparação da tendência temporal nas duas cidades mostrou a importância da melhora das condições de vida, do acesso a serviços de saúde para prevenção e controle dos fatores de risco, assim como assistência hospitalar aos casos para diminuirmos a mortalidade por DCBV em todo o território nacional.

Abstract Background Cerebrovascular disease (CBVD) is the second leading cause of death in the world and Brazil. Objective To evaluate trends in mortality from CBVD in two Brazilian cities (Maceió and Florianópolis) with extreme socioeconomic differences, between 1981 and 2016, estimating the age, cohort effect. Method Study of CBVD mortality time series in individuals aged ≥40 years, using the Age, Period, Cohort (APC) analysis and the Web tool. Results CBVD mortality decreased with time, increased with age and was lower for younger generations. The effect was the same for both sexes. There was a decrease in mortality in both cities, but the difference was large, and mortality remains high in Maceió. Based on the amplitude of the estimated effects, it was possible to verify that the cohort effect was the most significant term to explain the temporal variability of mortality rates due to CVD in the period. Conclusion The comparison of the time trend in the two cities showed the importance of improving living conditions, access to health services for the prevention and control of risk factors, as well as hospital care for cases to reduce mortality from CVD nationwide.

https://doi.org/10.1590/1414-462x202230030233

Impact of the COVID-19 pandemic on sleep quality and sleep bruxism in children eight to ten years of age
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Lima, Larissa Chaves Morais de

; Leal, Tiago Ribeiro

; AraúJo, Luíza Jordânia Serafim de

; Sousa, Myrelle Leal Campos

; Silva, Samara Ellen da

; Serra-Negra, Junia Maria Cheib

; Ferreira, Fernanda de Morais

; Paiva, Saul Martins

; Granville-Garcia, Ana Flávia

Brazilian Oral Research

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2022, Volume 36 elocation e046

Abstract: En | Text: En | PDF: En

Abstract: This study aimed to determine the impact of the COVID-19 pandemic on sleep quality and possible sleep bruxism (SB) in children eight to ten years of age. The study hypothesis was that sleep disturbances influenced a higher occurrence of bruxism during the COVID-19 pandemic. A longitudinal study was conducted at two time points: in person prior to the COVID-19 pandemic (T1), and online during the pandemic (T2). The sample comprised 105 children. Parents/caregivers answered a questionnaire addressing sociodemographic characteristics, the use of electronic devices, reported (vs. clinical) SB, and the Sleep Disturbance Scale for Children (SDSC) at both T1 and T2. McNemar’s and Wilcoxon’s tests were used to compare SB and sleep disorders at both time points. Poisson regression analysis determined the relative risk (RR) among the variables, and the incidence of possible SB (p≤0.05). The comparison of the two time points (T1 and T2) revealed a significant increase in possible SB (p<0.01) and sleep disorders (p < 0.04). Children whose parents had a lower schooling level (RR: 2.67; 95%CI: 1.19–6.01), those with their own electronic devices (RR: 1.97; 95%CI: 1.09–2.50), and those with sleep disorders during the pandemic (RR: 1.74; 95%CI: 1.35–2.24) were at greater risk of developing SB during the pandemic. Moreover, the incidence of bruxism and sleep disorders was greater during the pandemic. The factors influencing SB incidence during the pandemic were a lower level of mothers’ schooling, greater access to electronic devices, and the occurrence of sleep disorders.

https://doi.org/10.1590/1807-3107bor-2022.vol36.0046

Lack of association of the KIR and HLA class I ligands with ZIKV infection in south and southeast of Brazil
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Elpidio, Laise Nayana Sala

; de Moraes, Amarilis Giaretta

; Langer, Ieda Bernadete Volkweis

; do Amaral, Greicy Cezar

; Moretti, Maria Luiza

; Garcia, Márcia Teixeira

; Angerami, Rodrigo

; Proenca-Modena, José Luiz

; Bispo-dos-Santos, Karina

; Martini, Matheus Cavalheiro

; Parise, Pierina Lorencini

; Ayo, Christiane Maria

; de Mattos, Luiz Carlos

; Brandão, Cinara Cássia

; Nogueira, Maurício Lacerda

; Oliani, Denise Cristina Mós Vaz

; Spegiorin, Lígia Cosentino Junqueira Franco

; de Lima Neto, Quirino Alves

; Visentainer, Jeane Eliete Laguila

Memórias do Instituto Oswaldo Cruz

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2022, Volume 117 elocation e210194

Abstract: En | Text: En | PDF: En

BACKGROUND Zika virus (ZIKV) is an emerging arbovirus associated with foetal malformations and neurological complications. The infection is usually associated with mild symptoms. The comparison between the allelic frequency of polymorphic genes in symptomatic infected individuals in the population can clarify the pathogenic mechanisms of ZIKV. During ZIKV infection, cytokines are produced and natural killer (NK) cells are recruited, whose activation depends on signaling pathways activated by specific receptors, such as killer cell immunoglobulin-like receptors (KIR). These molecules interact with human leukocyte antigen (HLA) class I ligands and are encoded by polymorphic genes. OBJECTIVES This study aimed to evaluate the frequency of allelic variants of the genes encoding the KIR receptors and their HLA class I ligands in 139 symptomatic ZIKV-patients and 170 controls negative for the virus, and to evaluate the role of these variants for ZIKV susceptibility. METHODS KIR and HLA class I genes were genotyped using the polymerase chain reaction-sequence specific oligonucleotide (PCR-SSO) technique. FINDINGS No significant differences in the frequency distribution of KIRs and KIR-HLA in patients compared to controls were observed. MAIN CONCLUSIONS KIR and its HLA ligands might play a minor role in ZIKV infection in the south and southeast Brazilian individuals.

https://doi.org/10.1590/0074-02760210194

Características e Tendências na Mortalidade em Diferentes Fenótipos de Insuficiência Cardíaca na Atenção Primária
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Jorge, Antonio José Lagoeiro

; Barbetta, Leticia Mara dos Santos

; Correia, Eduardo Thadeu de Oliveira

; Martins, Wolney de Andrade

; Leite, Adson Renato

; Saad, Maria Auxiliadora Nogueira

; Santos, Márcia Maria Sales dos

; Correia, Dayse Mary

; Rosa, Maria Luiza Garcia

; Chermont, Sérgio

; Santos, Cárita Cunha dos

; Mesquita, Evandro Tinoco

Arquivos Brasileiros de Cardiologia

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aug 2021, Volume 117 N. 2 Pages 300 - 306

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Fundamento: A classificação da insuficiência cardíaca (IC) por fenótipos possui grande relevância na prática clínica. Objetivo: O estudo visou analisar a prevalência, as características clínicas e os desfechos entre os fenótipos de IC no contexto da atenção primária. Métodos: Trata-se de uma análise de um estudo de coorte que incluiu 560 indivíduos, com idade ≥ 45 anos, que foram selecionados aleatoriamente em um programa de atenção primária. Todos os participantes foram submetidos a avaliações clínicas, dosagem do peptídeo natriurético tipo B (BNP), eletrocardiograma e ecocardiografia em um único dia. A IC com fração de ejeção do ventrículo esquerdo (FEVE) < 40% foi classificado como IC com fração de ejeção reduzida (ICFEr), FEVE de 40% a 49% como IC com fração de ejeção intermediária (ICFEi) e FEVE ≥ 50% como IC com fração de ejeção preservada (ICFEp). Após 5 anos, os pacientes foram reavaliados quanto à ocorrência do desfecho composto de óbito por qualquer causa ou internação por doença cardiovascular. Resultados: Dos 560 pacientes incluídos, 51 pacientes tinham IC (9,1%), 11 dos quais tinham ICFEr (21,6%), 10 tinham ICFEi (19,6%) e 30 tinham ICFEp (58,8%). A ICFEi foi semelhante à ICFEp nos níveis de BNP (p < 0,001), índice de massa do ventrículo esquerdo (p = 0,037) e índice de volume do átrio esquerdo (p < 0,001). O fenótipo de ICFEi foi semelhante ao de ICFEr em relação à doença arterial coronariana (p = 0,009). Após 5 anos, os pacientes com ICFEi apresentaram melhor prognóstico quando comparados aos pacientes com ICFEp e ICFEr (p < 0,001). Conclusão: A prevalência de ICFEI foi semelhante ao observado em estudos anteriores. A ICFEI apresentou características semelhantes a ICFEP neste estudo. Nossos dados mostram que a ICFEi teve melhor prognóstico em comparação com os outros dois fenótipos.

Abstract Background: The classification of heart failure (HF) by phenotypes has a great relevance in clinical practice. Objective: The study aimed to analyze the prevalence, clinical characteristics, and outcomes between HF phenotypes in the primary care setting. Methods: This is an analysis of a cohort study including 560 individuals, aged ≥ 45 years, who were randomly selected in a primary care program. All participants underwent clinical evaluations, b-type natriuretic peptide (BNP) measurements, electrocardiogram, and echocardiography in a single day. HF with left ventricular ejection fraction (LVEF) < 40% was classified as HF with reduced ejection fraction (HFrEF), LVEF 40% to 49% as HF with mid-range ejection fraction (HFmrEF) and LVEF ≥ 50% as HF with preserved ejection fraction (HFpEF). After 5 years, the patients were reassessed as to the occurrence of the composite outcome of death from any cause or hospitalization for cardiovascular disease. Results: Of the 560 patients included, 51 patients had HF (9.1%), 11 of whom had HFrEF (21.6%), 10 had HFmrEF (19.6%) and 30 had HFpEF (58.8%). HFmrEF was similar to HFpEF in BNP levels (p < 0.001), left ventricular mass index (p = 0.037), and left atrial volume index (p < 0.001). The HFmrEF phenotype was similar to HFrEF regarding coronary artery disease (p = 0.009). After 5 years, patients with HFmrEF had a better prognosis when compared to patients with HFpEF and HFrEF (p < 0.001). Conclusion: The prevalence of ICFEI was similar to that observed in previous studies. ICFEI presented characteristics similar to ICFEP in this study. Our data show that ICFEi had a better prognosis compared to the other two phenotypes.

https://doi.org/10.36660/abc.20190912 165 downloads

Tendências Recentes de Mortalidade Cardiovascular nas Regiões de Saúde do Estado do Rio de Janeiro e Capital
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Rosa, Maria Luiza Garcia

; Mesquita, Claudio Tinoco

; Albuquerque, Lucas Zanetti de

; Silva, Willian Douglas de Souza

; Alves, Vinicius de Padua Vieira

; Jordan, Roger Freitas Ramirez

; Matos, Ricardo Cardoso de

; Silva, Ana Luisa Guedes de França e

; Souza Filho, Erito Marques de

Arquivos Brasileiros de Cardiologia

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apr 2021, Volume 116 N. 4 Pages 763 - 771

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Fundamento: A mortalidade por doenças cardiovasculares (DCV) vem mostrando tendência à estabilização em alguns países, incluindo o Brasil e o estado do Rio de Janeiro, após décadas de queda. Não encontramos análises detalhadas dessa tendência para o estado do Rio de Janeiro. Objetivo: Analisar as tendências da mortalidade prematura e tardia por doenças do aparelho circulatório (DAC), doença isquêmica do coração (DIC) e doença cerebrovascular (DCBV) por sexo nas regiões de saúde do estado do Rio de Janeiro e capital (1996-2016). Métodos: Dados de óbitos e população foram obtidos no DATASUS/MS. Taxas foram compensadas por códigos mal definidos, corrigidos pelos códigos cardiovasculares mal definidos e ajustadas por sexo e idade pelo método direto. O Joinpoint Trend Analysis Software foi empregado para calcular a variação percentual anual (APC) e variação percentual anual média (AAPC). Foram consideradas para o estudo APC e AAPC significativamente diferentes de zero, calculadas por um teste de student com significância de 5%. Resultados: A mortalidade por DIC estabilizou ou até aumentou em pelo menos 50% das localidades analisadas (EAPC ≥0). Nas regiões Norte e Noroeste, nenhuma mudança foi observada. Para DCBV, apenas uma região apresentou estabilidade na mortalidade (EAPC próximo a 0). Para as outras regiões, a taxa continuou a diminuir (APC <0) até 2016. Conclusão: Esses resultados observados no Rio de Janeiro devem se repetir em várias regiões brasileiras e apontam para a necessidade de uma resposta na abordagem dos comportamentos no estilo de vida. Os médicos da atenção primária devem estar familiarizados com a tendência desfavorável da doença isquêmica do coração entre os adultos mais jovens e rastrear ativamente os fatores de risco para DCV, com atenção especial às mulheres.

Abstract Background: Cardiovascular disease (CVD) mortality, after several decades of decrease, has shown a tendency towards the stabilization in some countries, including Brazil and Rio de Janeiro state. This new tendency was not further analyzed by gender, age group and region of the Rio de Janeiro state. Objective: To analyze the trends of premature and late mortality from CVD, ischemic heart disease (IHD) and cerebrovascular disease (CBVD) by gender in the city of Rio de Janeiro (capital) and the health regions of Rio de Janeiro state (from 1996 to 2016. Methods: Data on deaths and the population were obtained from DATASUS/MS. The rates were compensated by ill-defined codes, corrected by Ill-Defined Cardiovascular codes and gender and age-adjusted by the direct method (reference population – population of the state of Rio de Janeiro - 2000 census). The Joinpoint Trend Analysis Software was employed. Results: IHD mortality stabilized or even increased for at least 50% of the analyzed areas (EAPC≥0). No change was observed. in the “North” and “Northwest” regions For CBVD, just one region showed stability regarding mortality (EAPC close to 0). For the other regions, the rate continued to decrease (APC<0) until 2016. Conclusion: These results observed in Rio de Janeiro are possibly appropriate to various Brazilian regions and demonstrate that a serious public health response is needed to address lifestyle behaviors. Primary care physicians should also be familiar with the unfavorable tendency in coronary heart disease among younger adults in recent years and actively screen for risk factors for cardiovascular disease, paying special attention to women.

https://doi.org/10.36660/abc.20190742 366 downloads

10.

Segurança e educação durante a COVID-19: prevalência, fatores associados e planos de reabertura da Faculdade de Enfermagem
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Rafael, Ricardo de Mattos Russo

; Correia, Luiza Mara

; Mello, Alex Simões de

; Prata, Juliana Amaral

; Gallasch, Cristiane Helena

; Pérez Junior, Eugenio Fuentes

; Silva, Frances Valeria Costa e

; Penna, Lucia Helena Garcia

; Morera, Jaime Caravaca

; Breda, Karen Lucas

; David, Helena Maria Scherlowski Leal

Escola Anna Nery

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2021, Volume 25 N. spe elocation e20200528

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo Objetivo analisar a prevalência e os fatores associados à triagem da COVID-19 e propor as estratégias necessárias para a reabertura das Escolas de Enfermagem universitárias para as aulas presenciais. Métodos um estudo transversal foi projetado a partir da linha de base de uma pesquisa longitudinal baseada na Internet de uma Escola Brasileira de Enfermagem. Com o resultado ordinal (classificação operacional COVID-19), a análise de dados foi conduzida usando um modelo de regressão multinomial. Resultados um total de 498 participantes foi incluído na análise e revelou 67,27% de casos suspeitos e 11,65% de casos confirmados de COVID-19. O uso de máscaras, o transporte público e fazer parte da linha de frente dos trabalhadores da saúde foram estatisticamente associados a um histórico positivo para a COVID-19. Conclusão os planos de reabertura de Escolas de Enfermagem devem integrar o uso de equipamentos de proteção pessoal, o transporte público e a triagem da COVID-19 na educação.

Abstract Objective to analyze the prevalence and factors associated with COVID-19 screening and propose the necessary strategies for the reopening of university Nursing Schools to face-to-face classes. Methods aa cross-sectional study was designed from the baseline of a longitudinal Internet-based survey of a Brazilian School of Nursing. With the ordinal outcome (COVID-19 operational classification), data analysis was conducted using a multinomial regression model Results a total of 498 participants were included in the analysis and revealed 67.27% suspected and 11.65% confirmed cases of COVID-19. Wearing masks, public transportation, and being part of frontline healthcare workers were statistically associated with a positive history for COVID-19. Conclusion plans to reopen Nursing Schools must integrate the use of personal protective equipment, public transportation, and COVID-19 screening into education.

Resumen Objetivo analizar la prevalencia y los factores asociados al rastreo de COVID-19 y proponer las estrategias necesarias para la reapertura de Escuelas Universitarias de Enfermería para clases presenciales. Métodos se diseñó un estudio transversal a partir de la línea de base de una investigación longitudinal basada en Internet de una Escuela Brasileña de Enfermería. Con el resultado ordinal (clasificación operativa COVID-19), se realizó el análisis de datos mediante un modelo de regresión multinomial. Resultados se incluyeron en el análisis un total de 498 participantes que revelaron el 67,27% de los casos sospechosos y el 11,65% de los casos confirmados de COVID-19. El uso de máscaras, el transporte público y ser parte de la primera línea de los trabajadores de la salud se asociaron estadísticamente con un historial positivo de COVID-19. Conclusión los planes de reapertura de Escuelas de Enfermería deben integrar el uso de equipos de protección personal, transporte público y el rastreo de COVID-19 en la educación.

https://doi.org/10.1590/2177-9465-ean-2020-0528 460 downloads

11.

Development of clinical competence in nursing in simulation: the perspective of Bloom’s taxonomy
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Nascimento, Juliana da Silva Garcia

; Siqueira, Tainá Vilhar

; Oliveira, Jordana Luiza Gouvêa de

; Alves, Mateus Goulart

; Regino, Daniela da Silva Garcia

; Dalri, Maria Celia Barcellos

Revista Brasileira de Enfermagem

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2021, Volume 74 N. 1 elocation e20200135

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivos: investigar as evidências científicas existentes sobre a utilização da taxonomia de Bloom para o desenvolvimento de competência em profissionais e estudantes de enfermagem na simulação clínica. Métodos: revisão integrativa nas bases National Library of Medicine (NLM), National Institutes of Health (NIH), Cumulative Index to Nursing and Allied Health Literature (CINAHL), Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), Web of Science e SCOPUS com apoio do aplicativo Rayyan. Resultados: identificaram-se 871 estudos, e quatro compuseram a amostra. O desenvolvimento de competência clínica ocorreu articulando-se conhecimentos, habilidades e atitudes. Para desenvolver o domínio cognitivo, foram mobilizados os objetivos conhecer e compreender da taxonomia de Bloom. Para contemplar o domínio psicomotor, foi necessário desenvolver as habilidades demandadas no atendimento clínico proposto. O domínio afetivo foi desenvolvido por vontade e motivação para aprender. Conclusões: é possível desenvolver competência clínica em enfermagem adotando a taxonomia de Bloom em cada fase da simulação.

ABSTRACT Objectives: to investigate the scientific evidence on the use of Bloom’s taxonomy for developing competence in nursing professionals and students in clinical simulation. Methods: integrative review of the National Library of Medicine (NLM), National Institutes of Health (NIH), Cumulative Index to Nursing and Allied Health Literature (CINAHL), Latin American and Caribbean Literature in Health Sciences (LILACS), Web of Science and SCOPUS databases, using the Rayyan application. Results: a total of 871 studies were identified; four composed the sample. The development of clinical competence occurred through the coordination of knowledge, skills, and attitudes. To develop the cognitive domain, the objectives of knowledge and comprehension of the Bloom’s taxonomy were mobilized. The psychomotor domain required development of the skills demanded by the proposed clinical care. The affective domain was developed through will and motivation to learn. Conclusions: it is possible to develop clinical competence in nursing by adopting Bloom’s taxonomy in each phase of clinical simulation.

RESUMEN Objetivos: investigar las evidencias científicas existentes sobre la utilización de la taxonomía de Bloom para el desarrollo de competencias en profesionales y estudiantes de enfermería usando la simulación clínica. Métodos: revisión integrativa en las bases National Library of Medicine (NLM), National Institutes of Health (NIH), Cumulative Index to Nursing and Allied Health Literature (CINAHL), Literatura Latinoamericana y del Caribe en Ciencias de la Salud (LILACS), Web of Science y SCOPUS con el apoyo del aplicativo Rayyan. Resultados: se identificaron 871 estudios, cuatro hicieron parte de la muestra. El desarrollo de competencia clínica se consiguió articulando conocimientos, habilidades y actitudes. Para desarrollar el dominio cognitivo, fueron movilizados los objetivos conocer y comprender de la taxonomía de Bloom. Para contemplar el dominio psicomotor, fue necesario desarrollar las habilidades determinadas en la atención clínica propuesta. El dominio afectivo fue desarrollado por el deseo y motivación para aprender. Conclusiones: es posible desarrollar competencia clínica en enfermería adoptando la taxonomía de Bloom en cada etapa de la simulación.

https://doi.org/10.1590/0034-7167-2020-0135 1429 downloads

12.

Clinical outcomes and molecular characterization of drug-resistant tuberculosis in pre- and extensively drug-resistant disease based on line probe assays
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Araújo, Lauane G.

; Garcia, Márcia T.

; Zaccariotto, Tânia R.

; Moretti, Maria Luiza

; Levy, Carlos E.

; Resende, Mariângela R.

Brazilian Journal of Infectious Diseases

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2021, Volume 25 N. 1 elocation 101544

Abstract: En | Text: En | PDF: En

ABSTRACT Multidrug-resistant tuberculosis (MDR-TB) represents a significant impact in transmission, outcome, and health costs. The World Health Organization recommends implementation of rapid diagnostic methods for multidrug-resistance detection. This study was performed to evaluate the frequency of pre- and extensively drug resistant tuberculosis (pre-XDR-TB and XDR-TB) among MDR-TB patients, the pattern of resistance mutations for fluoroquinolones and the clinical outcome. Adult patients followed at a Brazilian regional reference center for TB, from January 2013 to June 2019 were included. Stored Mycobacterium tuberculosis (Mtb) cultures were recovered, the DNA was extracted, and the susceptibility test was performed using the line probe assay for second line antimycobacterial drugs, Genotype MTBDRsl version 2.0 (Hain Lifescience, CmbH, Germany). Among 33 MDR-TB included patients, we diagnosed XDR-TB or pre-XDR in five (15%) cases. Of these, mutations related to fluoroquinolones resistance were observed in four Mtb isolates, including one who had no phenotypic resistance profile. In two other patients with phenotypic resistance to ofloxacin, genotypic resistance was not found. Case fatality rate was 60% in pre/XDR-TB group, compared to 3.6% in the remaining of patients. This study observed few cases of pre-XDR and XDR-TB among a MDR-TB cohort. Phenotypic and genotypic assays presented good agreement. Clinical outcome was more favorable for patients with susceptibility to fluoroquinolones and injectable drugs.

https://doi.org/10.1016/j.bjid.2021.101544 156 downloads

13.

Instructor-led oral debriefing technique in clinical nursing simulation: integrative review
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Nascimento, Juliana da Silva Garcia

; Pires, Fabiana Cristina

; Castro, João Pedro Resende

; Nascimento, Kleiton Gonçalves do

; Oliveira, Jordana Luiza Gouvêa de

; Dalri, Maria Celia Barcellos

Revista Brasileira de Enfermagem

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2021, Volume 74 Suppl. 5 elocation e20190750

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivo: Analisar as evidências científicas disponíveis na literatura sobre os elementos que viabilizam a técnica de debriefing oral orientado por instrutor na simulação clínica em enfermagem. Métodos: Revisão integrativa da literatura realizada nas fontes de informação: PubMed®, Scopus, Web of Science, Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), Cumulative Index to Nursing and Allied Health Literature (CINAHL) e Educational Resources Information Centre (ERIC). Resultados: Identificaram-se 284 estudos, e 5 compuseram a amostra. Quatro elementos constituem o debriefing oral: características do instrutor; formato da discussão, estrutura do debriefing; e tempo. O principal benefício foi desenvolver habilidades cognitivas e psicomotoras; e o desafio, estabelecer treinamento aos instrutores. Os estudos apresentaram alta qualidade metodológica. Considerações finais: O aprofundamento científico quanto aos elementos, benefícios e desafios do debriefing oral possibilita sua execução e confere qualidade ao processo para enfermagem.

ABSTRACT Objective: To analyze available scientific evidence in literature pertaining to the elements that make the instructor-led oral debriefing technique in clinical nursing simulation feasible. Methods: An Integrative literature review along the following information sources: PubMed®, Scopus, Web of Science, Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS) [Latin American and Caribbean Health Sciences Literature], Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Educational Resources Information Centre (ERIC). Results: 284 studies were identified, and 5 composed the sample. Four elements constitute oral debriefing: characteristics of the instructor; discussion format, debriefing structure; and time frame. The main benefit was to develop cognitive and psychomotor skills; and the challenge was to establish training for instructors. The studies showed high methodological quality. Final Considerations: The scientific deepening as to the elements, benefits, and challenges of oral debriefing enables its execution and offers quality to the nursing process.

RESUMEN Objetivo: Analizar las evidencias científicas disponibles en la literatura sobre los elementos que hacen viable la técnica de debriefing oral orientado por instructor en la simulación clínica en enfermería. Métodos: Revisión integrativa de la literatura realizada en las fuentes de información: PubMed®, Scopus, Web of Science, Literatura Latinoamericana y del Caribe en Ciencias de Salud (LILACS), Cumulative Index to Nursing and Allied Health Literature (CINAHL) y Educational Resources Information Centre (ERIC). Resultados: Se identificaron 284 estudios, y 5 compusieron la muestra. Cuatro elementos constituyen el debriefing oral: características del instructor; formato de la discusión, estructura del debriefing; y tiempo. El principal beneficio ha sido desarrollar habilidades cognitivas y psicomotrices; y el desafío, establecer entrenamiento a los instructores. Los estudios presentaron alta calidad metodológica. Consideraciones finales: La profundización científica cuanto a los elementos, beneficios y desafíos del debriefing oral posibilita su ejecución y confiere calidad al proceso para enfermería.

https://doi.org/10.1590/0034-7167-2019-0750 343 downloads

14.

DEBRIEFING: DESENVOLVIMENTO E VALIDAÇÃO DE UM ROTEIRO PARA SIMULAÇÃO DO SUPORTE BÁSICO DE VIDA
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Nascimento, Juliana da Silva Garcia

; Nascimento, Kleiton Gonçalves do

; Regino, Daniela da Silva Garcia

; Alves, Mateus Goulart

; Oliveira, Jordana Luiza Gouvêa de

; Dalri, Maria Celia Barcellos

Cogitare Enfermagem

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2021, Volume 26 elocation e79537

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivo desenvolver e validar um roteiro para planejar e executar o debriefing oral orientado por único facilitador, na simulação clínica do Suporte Básico de Vida Método estudo metodológico, realizado em uma universidade pública do estado de São Paulo, Brasil, entre julho e novembro de 2020. Procedeu-se a síntese das evidências do roteiro por meio de revisão e sua validação com 16 juízes, adotando-se o Índice de Validade de Conteúdo Resultados identificaram-se 284 estudos e selecionaram-se cinco. Os conteúdos são: definição e objetivo do debriefing, características do instrutor; público-alvo; objetivos de aprendizagem; método de debriefing; recursos materiais; procedimento; tempo e referências. O roteiro atingiu Índice de Validade de Conteúdo de 0,95 Conclusão considerou-se o roteiro válido e capaz de contribuir com a pesquisa, assistência e ensino em enfermagem, por conduzir o planejamento e a execução do debriefing no Suporte Básico de Vida, e ser adaptável a outras realidades em saúde

ABSTRACT Objective to develop and validate a script to plan and execute the oral debriefing guided by a single facilitator in the clinical simulation of Basic Life Support Method methodological study, conducted at a public university in the state of São Paulo, Brazil, between July and November 2020. We proceeded to synthesize the evidence of the script through review and its validation with 16 judges, adopting the Content Validity Index Results 284 studies were identified and five were selected. The contents are definition and objective of the debriefing; characteristics of the instructor; target audience; learning objectives; debriefing method; material resources; procedure; time; and references. The script reached a Content Validity Index of 0.95 Conclusion the script was considered valid and capable of contributing to research, assistance and teaching in nursing, for conducting the planning and execution of debriefing in Basic Life Support and being adaptable to other health realities

RESUMEN Objetivo desarrollar y validar un guion para planificar y ejecutar el debriefing oral guiado por un único facilitador en la simulación clínica de Soporte Básico de Vida Método estudio metodológico, realizado en una universidad pública del estado de São Paulo, Brasil, entre julio y noviembre de 2020. Las pruebas del guion se sintetizaron mediante la revisión y validación con 16 jueces, utilizando el Índice de Validez de Contenido Resultados Se identificaron 284 estudios y se seleccionaron cinco. Los contenidos son: definición y propósito del debriefing, características del instructor; público objetivo; objetivos de aprendizaje; método de debriefing; recursos materiales; procedimiento; tiempo y referencias. El guion alcanzó un Índice de Validez de Contenido de 0,95 Conclusión el guion se consideró válido y capaz de contribuir a la investigación, la asistencia y la docencia en enfermería, ya que conduce a la planificación y ejecución del debriefing en Soporte Básico de Vida, y es adaptable a otras realidades de salud

https://doi.org/10.5380/ce.v26i0.79537

15.

Callus induction and pro-embryogenic mass formation in Myrciaria dubia, an important medicinal and nutritional plant
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Araújo, Maria da Conceição da Rocha

; Chagas, Edvan Alves

; Vendrame, Wagner

; Ribeiro, Maria Isabel Garcia

; Moura, Elias Ariel de

; Taveira, Daniel Lucas Lima

; Chagas, Pollyana Cardoso

; Grigio, Maria Luiza

Crop Breeding and Applied Biotechnology

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2021, Volume 21 N. 3 elocation e25442131

Abstract: En | Text: En | PDF: En

Abstract: Caçari is a fruit tree that is native to the Amazon region of Brazil. The fruit is considered to have the highest vitamin C content of any edible fruit (13.757 mg 100 g-1 dry weight). The objective of this study was to evaluate the effects of 2,4-D and 6-BAP alone or in combination on in vitro callus induction and pro-embryogenic mass formation in caçari stem segments in different culture media as a precursor for caçari micropropagation. The experiment consisted of two culture media (MS and WPM) and combinations of four concentrations of 2,4-D (0, 1, 2 and 4 mg L-1) and BAP (0, 0.25, 0.5 and 1 mg L-1). The results showed that the highest percentage of callus formation (99%) was obtained in WPM supplemented with 4 mg L-1, 2,4-D and 1 mg L-1 BAP, and this combination resulted in 93% pro-embryogenic mass formation.

https://doi.org/10.1590/1984-70332021v21n3a40 48 downloads

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