Abstract: Liposarcomas correspond to the most common histological subtype of soft tissue sarcomas. They can be subdivided into: well differentiated or atypical lipoma, undifferentiated, myxoid, round, and pleomorphic cells. Atypical lipomas are the most prevalent and usually appear as asymptomatic softened tumors. They are locally aggressive but rarely lead to distant metastases. The diagnosis of this tumor is based on the imaging and histopathologic findings. Treatment consists of excision surgery with complete tumor removal. It has a good prognosis due to the low percentage of distant metastases. We report a rare case of giant atypical lipoma as well as the adopted therapy and evolution.

Abstract: Although giant congenital melanocytic nevus is a rare lesion, it causes significant deformity and carries a risk of malignant degeneration. Different surgical techniques for the lesion removal are described, including serial resection, resection with skin grafting, and resection and coverage with expanded skin flap (skin expanders). The aim of this study is to report the author's 40 years of experience with cases requiring at least 4 serial excisions to complete the treatment. Serial resection is an effective, safe, and simple technique that requires a lot of patience. Treatment often results in a single linear scar, requires no donor sites, nor large flaps. It is not subject to potencial complications of expanders and avoid aesthetic deformities depending on the location.

RESUMO: O objetivo deste trabalho foi avaliar o controle de cominho (Fimbristylis miliacea ) e a seletividade à cultura do arroz irrigado com a mistura em tanque de bispyribac-sodium + metsulfuron-methyl associada a adjuvantes. Conduziu-se o experimento no município de Douradina (23º12'32,0" Sul, 53º17'39,9" Oeste), PR, no ano agrícola 2012/2013. O delineamento experimental utilizado foi o de blocos completos casualizados com dez tratamentos e quatro repetições. Os tratamentos foram constituídos pela aplicação da mistura em tanque dos herbicidas bispyribac-sodium + metsulfuron-methyl, em duas doses (32+1,3 e 40+3,3 g i.a. ha-1), e com adjuvantes Iharaguen(r) (375 mL.ha-1), Orobor N1(r) (75 mL.ha-1), LI 700(r) (150 mL.ha-1) e TA 35(r) (50 mL.ha-1), assim como de testemunha capinada e sem capina. Apesar de a eficácia de controle de cominho (F. miliacea ) com a mistura em tanque de bispyribac-sodium + metsulfuron-methyl associada aos adjuvantes Iharaguen(r) e Orobor N1(r) ter sido significativamente superior ao LI 700(r) e TA 35(r), não foram constatadas diferenças significativas entre os tratamentos em termos de seletividade e produtividade de grãos para o cultivar de arroz Epagri 108.

ABSTRACT: This study aimed to evaluate the control of globe fringerush (Fimbristylis miliacea ) and selectivity to rice crop irrigated with an in-tank mixture of bispyribac-sodium + metsulfuron-methyl associated with adjuvants. The experiment was conducted in the municipality of Douradina, Paraná state, Brazil (23º12'32.0" South, 53º17'39.9" West), in the agricultural year of 2012/2013. An experimental randomized complete block design with ten treatments and four replications was used. The treatments consisted of applying an in-tank mixture of the herbicides bispyribac-sodium + metsulfuron-methyl at two doses (32+1.3 and 40+3.3 g ai ha-1) associated with the adjuvants Iharaguen(tm) (375 mL.ha-1), Orobor N1(tm) (75 mL.ha-1), LI 700(tm) (150 mL.ha-1) and TA 35(tm) (50 mL.ha-1), as well as weeded and unweeded control. Although the effectiveness of globe fringerush (F. miliacea ) control with the in-tank mixture of the herbicides bispyribac-sodium + metsulfuron-methyl associated with Iharaguen(tm) and Orobor N1(tm) has been significantly higher than the effectiveness of these herbicides associated with LI 700(tm) and TA 35(tm), there were no significant differences among the treatments in terms of selectivity and grains yield of the rice cultivar Epagri 108.

Arrabidaea chica (H&B) Verlot is a plant popularly known as Pariri and this species is a known source of anthocyanins, flavonoids and tannins. This report describes an approach involving enzymatic treatment prior to extraction procedures to enhance A chica crude extract anticancer activity. Anticancer activity in human cancer cell lines in vitro using a 48 h SRB cell viability assay was performed to determine growth inhibition and cytotoxic properties. The final extraction yield without enzyme treatment was higher (24.28%) compared to the enzyme-treated material (19.03%), with an enhanced aglycones anthocyanin ratio as determined by HPLC- DAD and LC-MS with direct infusion.

Activity guided fractionation of Sinningia allagophylla (Mart.) Wiehler ethanolic extract yielded a new benzochromene 8-methoxylapachenol, besides seven known compounds: lapachenol, sitosteryl oleate, sitosteryl linoleate, stigmasteryl oleate, stigmasteryl linoleate, dunniol and tectoquinone. Extract, fractions, and compounds lapachenol, 8-methoxylapachenol, and dunniol were tested in vitro against human cancer cell lines U251 (glioma, CNS), MCF-7 (breast), NCI-ADR/RES (drug-resistant ovarian), 786-0 (kidney), NCI-H460 (lung, no small cells), PC-3 (prostate), OVCAR-3 (ovarian), HT-29 (colon), K562 (leukemia) and against VERO, a normal cell line. The most active compound was dunniol, which inhibited the growth of U251, MCF-7, NCI-ADR/RES, OVCAR-3 and K562 cell lines.