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ABSTRACT Objective: To understand the structures of social networks of interiorized Venezuelan immigrant families and the life cycle stage they are in. Methods: Qualitative multiple-case study with families from the Interiorization Program residing in the Greater Florianópolis, Brazil. Screening occurred through social networks and key informants. For data collection, the photovoice technique and semi-structured interviews were used, categorized with the help of the Atlas.ti software. Genograms and ecomaps were elaborated. Results: Of the 4 families interviewed, totaling 7 members with young children, the nuclear family was identified as the main informal support network. Formal networks included schools, churches, and civil society. Conclusion: Families rely heavily on their nuclear structure for support, with formal institutions acting as secondary resources. The predominant life cycle stage is focused on families with young children. More efforts are needed to strengthen formal support networks.

RESUMEN Objetivo: Comprender las estructuras de las redes sociales de familias inmigrantes venezolanas interiorizadas y la fase del ciclo de vida en la que se encuentran. Métodos: Estudio cualitativo de múltiples casos con familias del Programa de Interiorización residentes en la Gran Florianópolis, Brasil. La selección se realizó a través de redes sociales e informantes clave. Para la recopilación de datos, se utilizó la técnica de fotovoz y entrevistas semiestructuradas, categorizadas con la ayuda del software Atlas.ti. Se elaboraron genogramas y ecomapas. Resultados: De las 4 familias entrevistadas, totalizando 7 miembros con hijos pequeños, se identificó a la familia nuclear como principal red de apoyo informal. Las redes formales incluyeron escuelas, iglesias y sociedad civil. Conclusiones: Las familias dependen en gran medida de su estructura nuclear para el apoyo, con las instituciones formales actuando como recursos secundarios. La fase predominante del ciclo de vida se centra en familias con hijos pequeños. Se requieren más esfuerzos para fortalecer las redes de apoyo formales.

RESUMO Objetivo: Compreender as estruturas das redes sociais de famílias imigrantes venezuelanas interiorizadas e a fase do ciclo vital em que se encontram. Métodos: Estudo qualitativo de múltiplos casos com famílias do Programa de Interiorização residentes na Grande Florianópolis, Brasil. A triagem ocorreu por meio de redes sociais e informantes-chave. Para a coleta de dados, utilizou-se a técnica de photovoice e entrevistas semiestruturadas, categorizadas com a ajuda do software Atlas.ti. Foram elaborados genogramas e ecomapas. Resultados: Das 4 famílias entrevistadas, totalizando 7 membros com filhos pequenos, identificou-se a família nuclear como principal rede de apoio informal. As redes formais incluíram escolas, igrejas e sociedade civil. Considerações finais: As famílias dependem fortemente de sua estrutura nuclear para apoio, com instituições formais atuando como recursos secundários. A fase do ciclo vital predominante está focada em famílias com filhos pequenos. Mais esforços são necessários para fortalecer as redes de apoio formais.

https://doi.org/10.1590/0034-7167-2022-0790

A puericultura no SUS: o cuidado da criança na perspectiva da atenção integral à saúde
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Albernaz, Antonio Luiz Goncalves

; Couto, Maria Cristina Ventura

Saúde em Debate

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dec 2022, Volume 46 N. spe5 Pages 236 - 248

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT The term childcare is attributed to pediatricians but has been used by the Family Health Strategy. This article makes a brief history of childhood and the evolution of its care until the creation of the Unified Health System (SUS). The premise is that childcare has always meant child care. This essay aimed to understand the history of childcare and contribute to update its meaning and importance for early childhood care in the context of Primary Health Care, based on the narrative review on child care and childcare in the scientific literature and documents from the Ministry of Health. Childcare has been updated with the evolution of actions for child care. It started individually, through charity and philanthropy, and today it has expanded, operating in a network, coordinated by Primary Care. The term childcare is rescued as child care and inserted in the network through public policies. Care should be offered from the perspective of comprehensive health care, wherever the child is, meeting their needs, including those of children with permanent disabilities. These debates need to be included in the training of pediatricians and can contribute to coping with the fragmentation of care.

RESUMO O termo puericultura é atribuído ao pediatra, mas tem sido utilizado pela Estratégia Saúde da Família. Uma breve história da infância e da evolução do seu cuidado até a criação do Sistema Único de Saúde auxilia na compreensão de que, a rigor, puericultura sempre significou cuidado da criança. Este ensaio teve por objetivo compreender a história da puericultura e contribuir para atualizar o seu significado e sua importância para o cuidado da primeira infância no âmbito da Atenção Básica à saúde, com base em revisão narrativa sobre cuidado da criança e puericultura na literatura científica e em documentos do Ministério da Saúde. A puericultura tem se atualizado com a evolução das ações para o cuidado da criança. Começou de forma individualizada, pela caridade e filantropia, e, na atualidade, ampliou-se, operando em rede, coordenada pela Atenção Básica. O termo puericultura é resgatado como cuidado da criança e inserido na rede por meio de políticas públicas. O cuidado deve ser oferecido na perspectiva da atenção integral à saúde, onde a criança estiver, atendendo às suas necessidades, incluindo as de crianças com deficiências permanentes. Esses debates precisam estar inseridos na formação do pediatra e podem contribuir para o enfrentamento da fragmentação do cuidado.

https://doi.org/10.1590/0103-11042022e519

A puericultura no SUS: o cuidado da criança na perspectiva da atenção integral à saúde
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Albernaz, Antonio Luiz Goncalves

; Couto, Maria Cristina Ventura

Saúde em Debate

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dec 2022, Volume 46 N. spe5 Pages 236 - 248

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

https://doi.org/10.1590/0103-11042022e519

Pessoas com Deficiência e COVID-19 no estado do Espírito Santo, Brasil: entre a invisibilidade e a falta de Políticas Públicas
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Melo, Douglas Christian Ferrari de

; Siqueira, Priscila Carminati

; Maciel, Ethel Leonor Noia

; Delcarro, Jessica Cristina Silva

; Robaina, Igor Martins Medeiros

; Jabor, Pablo Medeiros

; Goncalves Junior, Etereldes

; Zandonade, Eliana

Ciência & Saúde Coletiva

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nov 2022, Volume 27 N. 11 Pages 4203 - 4212

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O objetivo deste artigo é analisar o perfil das pessoas com deficiência dentre os casos notificados pelo painel COVID-19 do Espírito Santo e possíveis associações com o resultado positivo do teste COVID-19. Estudo Transversal descritivo entre as pessoas com deficiência com testes positivos e negativos para o diagnóstico de COVID-19. Foram realizadas associações das variáveis epidemiológicas e clínicas, utilizando o teste qui-quadrado e modelos de regressão logística para se estimar o odds ratio. A letalidade por COVID-19 foi de 4,9% (175 casos) no grupo das pessoas com deficiência, e 3% (3.016) no grupo sem deficiência. Pessoas com deficiência do sexo masculino (OR=1,34; IC95% 1,22-1,47), raça/cor preta (OR=1,55; IC95% 1,09-2,20), e as que ficaram internadas (OR=2,27; IC95% 1,71-3,02) apresentaram associação com testes positivos para COVID-19. A pandemia enfatiza a necessidade de criar mecanismos legais de cuidados específicos e políticas públicas focalizadas para essa população.

Abstract This article aims to analyze the profile of people with disabilities among the cases notified by the COVID-19 panel of Espírito Santo and the possible associations with the positive result of the COVID-19 test. Descriptive cross-sectional study among people with disabilities with positive and negative tests for the diagnosis of COVID-19. Associations of epidemiological and clinical variables were performed using the chi-square test and logistic regression models to estimate the odds ratio. Lethality rate of COVID-19 was 4.9% (175 cases) in the group of people with disabilities, and 3% (3,016) in the group without disabilities. People with disabilities, male (OR=1.34; 95%CI 1.22-1.47), race/black color (OR=1.55; 95%CI 1.09-2.20), and those who were hospitalized (OR=2.27; 95%CI 1.71-3.02) were associated with positive tests for COVID-19. The pandemic emphasizes the need to create specific legal care mechanisms and targeted public policies for this population.

https://doi.org/10.1590/1413-812320222711.08232022

Pessoas com Deficiência e COVID-19 no estado do Espírito Santo, Brasil: entre a invisibilidade e a falta de Políticas Públicas
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Melo, Douglas Christian Ferrari de

; Siqueira, Priscila Carminati

; Maciel, Ethel Leonor Noia

; Delcarro, Jessica Cristina Silva

; Robaina, Igor Martins Medeiros

; Jabor, Pablo Medeiros

; Goncalves Junior, Etereldes

; Zandonade, Eliana

Ciência & Saúde Coletiva

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nov 2022, Volume 27 N. 11 Pages 4203 - 4212

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1413-812320222711.08232022

The conception, content validation, and test-retest reliability of the Questionnaire for Screen Time of Adolescents (QueST)
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Knebel, Margarethe Thaisi Garro

; Costa, Bruno Goncalves Galdino da

; Santos, Priscila Cristina dos

; Sousa, Ana Caroline Ferreira Campos de

; Silva, Kelly Samara

Jornal de Pediatria

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apr 2022, Volume 98 N. 2 Pages 175 - 182

Abstract: En | Text: En | PDF: En

Abstract Objective: To analyze the content validity and the test-retest reliability of the Questionnaire for Screen Time of Adolescents (QueST). Methods: A study was conducted with high school adolescents from Southern Brazil enrolled in public education (2019). The QueST measures screen time across five constructs: studying, working/internship-related activities, watching videos, playing games, using social media/chat applications. Content validation involved consulting with experts and adolescents to evaluate whether the five constructs were clear and representing screen time behaviors, all ratings were quantified. The experts’ evaluation provided Content Validity Indexes (CVI) for clarity and representativeness of the questionnaire. Students answered the QueST twice (1-week apart), and differences between applications were verified. Test-retest reliability was assessed using Intraclass Correlation Coefficients (ICC) and Bland-Altman analyses. Results: Among the experts, the CVI indicated 94% and 98% of clarity and representativeness, respectively. All items were highly clear for at least 70% of the students. Test-retest reliability was assessed with 104 students (16.3 ± 1.02 years; 66.3% girls). The ICC ranged from 0.41 (95%CI 0.24–0.56) for videos to 0.76 (95%CI 0.66–0.83) for social media/chat applications on weekdays; and from 0.24 (95%CI 0.04–0.41) for videos to 0.67 (95%CI 0.54–0.77) for social media/chat applications on weekends. The lowest mean difference was -4.6 min for working on weekdays, while the highest was 40.6 min for videos on weekends. Conclusions: The QueST proved to be fair to excellent for measuring different screen time constructs. However, the item of videos (weekends) showed poor stability. The QueST demonstrates satisfactory content validity attested by the experts and adolescents.

https://doi.org/10.1016/j.jped.2021.05.004

Monitoramento orientado pela área sob a curva da vancomicina em pacientes pediátricos
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Morales Junior, Ronaldo

; Juodinis, Vanessa D’Amaro

; Santos, Isabela Cristina Pinheiro de Freitas

; Campioni, Camila Canuto

; Wirth, Flávia Gatto de Almeida

; Barbosa, Livia Maria Goncalves

; Souza, Daniela Carla de

; Santos, Silvia Regina Cavani Jorge

Revista Brasileira de Terapia Intensiva

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mar 2022, Volume 34 N. 1 Pages 147 - 153

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Avaliar a probabilidade de atingir o alvo pela razão entre a área sob a curva e a concentração inibitória mínima de vancomicina em pacientes pediátricos após o esquema de dose empírica e demonstrar a aplicabilidade desse método para o monitoramento da vancomicina. Metódos: Foi realizado um estudo de coorte retrospectivo que incluiu pacientes pediátricos com função renal normal internados entre janeiro e dezembro de 2020. O modelo de um compartimento com cinética de primeira ordem foi utilizado para estimar os parâmetros farmacocinéticos, e a área sob a curva foi calculada pela regra do trapézio. O alvo terapêutico foi definido como a razão entre a área sob a curva e a concentração inibitória mínima ≥ 400 e < 600. O teste do qui-quadrado foi aplicado para comparar a probabilidade de atingir o alvo nos grupos etários, enquanto os parâmetros farmacocinéticos foram comparados pelo teste de Kruskal-Wallis com o teste de Dunn para análises post hoc. Consideraram-se significativos os valores de p < 0,05. Resultados: Foram analisados, no total, 42 pares de níveis de vancomicina de 17 pacientes inscritos neste estudo. Após a dose diária empírica de vancomicina, o alvo terapêutico foi atingido em cinco (29%) pacientes; quatro pacientes (24%) apresentavam razão entre a área sob a curva inicial supraterapêutica e o valor de concentração inibitória mínima (> 600mg.h/L) e oito (47%) tinham valores subterapêuticos (< 400mg.h/L). Os patógenos mais identificados foram Staphylococcus spp. (n = 7). Os níveis de vale e as áreas sob a curva mostraram valores moderados de correlação (R2 = 0,73). Um (6%) paciente apresentou lesão renal aguda. Conclusão: A maioria dos pacientes não atingiu o alvo terapêutico com esquema de dose empírica de vancomicina, e a implementação de dosagem baseada na área sob a curva usando duas medições de amostra permitiu ajustes de dose em tempo real com base nos parâmetros farmacocinéticos dos indivíduos.

ABSTRACT Objective: To assess the percentage of vancomycin area under the curve/minimum inhibitory concentration target attainment in pediatric patients after the empirical dose regimen and to demonstrate the applicability of this method for vancomycin monitoring. Methods: A retrospective cohort study was performed including pediatric patients with normal renal function admitted between January 2020 and December 2020. The one-compartment model with first-order kinetics was used to estimate the pharmacokinetic parameters, and the area under the curve was calculated by the trapezoidal rule. The therapeutic target was defined as area under the curve/minimum inhibitory concentration ≥ 400 and < 600. The Chi-squared test was applied to compare the percentage of target attainment over age groups, while the pharmacokinetic parameters were compared by the Kruskal-Wallis test with Dunn’s test for post hoc analyses. We considered significant p-values < 0.05. Results: In total, 42 pairs of vancomycin levels were analyzed from 17 patients enrolled in this study. After empirical vancomycin daily dosing, the therapeutic target was achieved in five (29%) patients; four patients (24%) had a supratherapeutic initial area under the curve/minimum inhibitory concentration value (> 600mg.h/L), and eight (47%) patients had subtherapeutic values (< 400mg.h/L). The most identified pathogens were Staphylococcus spp. (n = 7). Trough levels and areas under the curve showed moderate correlation values (R2 = 0.73). Acute kidney injury occurred in one (6%) patient. Conclusion: Most patients did not reach the therapeutic target with a vancomycin empirical dose regimen, and the implementation of area under the curve-based dosing using two sample measurements allowed for real-time dose adjustments based on individuals’ pharmacokinetic parameters.

https://doi.org/10.5935/0103-507x.20220009-pt

FOXP3 variants are independently associated with transforming growth factor B1 plasma levels in female patients with inflammatory bowel disease
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Inoue, Cláudia Junko

; Flauzino, Tamires

; Goncalves, Beatriz Piantoni

; Paula, Jaqueline Costa Castardo de

; Galvão, Talita Cristina

; Miyazaki, Paula Kikuchi

; Alcantara, Camila Cataldi de

; Westmore, Lucilene Rosa e Silva

; Lozovoy, Marcell Alysson Batisti

; Reiche, Edna Maria Vissoci

; Simão, Andréa Name Colado

Clinics

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2022, Volume 77 elocation 100084

Abstract: En | Text: En | PDF: En

Abstract Objective: The aim of this study was to evaluate the association of -924 G>A (rs2232365) and -3279 C>A (rs3761548) FOXP3 variants with IBD susceptibility, clinical and endoscopic activity, and IL-10 and TGF-β1 plasma levels. Method: The study included 110 IBD female patients, 60 with Ulcerative Colitis (UC) and 50 with Crohn’s Disease (CD), and 154 female controls. FOXP3 variants were determined with Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP). Plasma levels of IL-10 and TGF-β1 were determined using immuno-fluorimetric assay. Results: AA genotype of rs2232365 and rs3761548 was associated with CD (OR = 3.147, 95% CI 1.015-9.758, p = 0.047) and UC (OR = 3.221, 95% CI 1.050-9.876, p = 0.041) susceptibility, respectively. However, were not associated with TGF-β1 and IL-10 levels, and endoscopic/clinical activity disease. GAGA haplotype was associated with IBD (OR = 4.003, 95% CI 1.100–14.56, p = 0.035) and UC susceptibility (OR = 6.107, 95% CI 1.609–23.18, p = 0.008). In addition, IBD patients with the GAGA haplotype had lower TGF-β1 levels (p = 0.041). Moreover, G/C haplotype (dominant model) had a protective effect of 60% in CD susceptibility and lower Endoscopic Severity Index. Conclusions: These results suggest that FOXP3 variants could exert a role in the Treg, which could be one of the factors involved in the susceptibility and pathogenesis of IBD.

https://doi.org/10.1016/j.clinsp.2022.100084

Wound healing in weaning, adult, and old rats with provoked incisional hernias. A comparative study
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Amaral, Raphael Nogueira do

; Tannuri, Ana Cristina Aoun

; Neri, Junia Marielle Teixeira Rodrigues

; Reis, Hugo de Souza

; Goncalves, Josiane Oliveira

; Serafini, Suellen

; Tannuri, Uenis

Clinics

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2022, Volume 77 elocation 100106

Abstract: En | Text: En | PDF: En

Abstract Background: Incisional hernias are more frequent in adults than in children. It is hypothesized that a more efficient healing process in pediatric patients could explain this difference in incidence. Certain elements of healing such as neovascularization, degree of inflammation, percentage of mature and immature collagen, the proliferation of fibroblasts, and expression of certain genes could explain why healing in children is more efficient when compared to the adult and elderly populations. Materials and methods: Seventy-one rats of 3 different age groups (weaning, adult, and old) underwent surgery with 3 different incisions (vertical, oblique, and horizontal). During the procedure, the skin and abdominal wall of the animal were sectioned and only the skin was sutured to mimic incisional hernia in the animals. Four weeks after surgery, the rats were euthanized, their skin was removed, and the extent of scar tissue formed in the muscle opening was measured. In addition, samples of the scar tissue were collected for histological, immunohistochemical, and molecular analyzes. Nine rats served as controls. Results: Shorter-length hernias were formed in weaning rats when compared to old ones when the surgical incision was horizontal (p = 0.03). There was a greater proliferation of fibroblasts in rats in the younger age groups, regardless of the type of incision. The Lox gene was more expressed in weaning rats with vertical and oblique incisions. Conclusions: These differences could explain the better healing and lower incidence of hernias in the pediatric population, although this aspect requires further studies.

https://doi.org/10.1016/j.clinsp.2022.100106

10.

Migraine in 746 patients with multiple sclerosis
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Fragoso, Yara Dadalti

; Adoni, Tarso

; Alves-Leon, Soniza V.

; Apostolos-Pereira, Samira L.

; Carneiro, Marcos A. Diniz

; Chikota, Edila M.

; Diniz, Denise Sisterolli

; Eboni, Audred C. B.

; Gomes, Sidney

; Gonçalves, Marcus Vinicius M.

; Goncalves, Ricardo Pereira

; Inojosa, José Luiz

; Junqueira, Thiago F.

; Machado, Suzana Costa

; Malfetano, Fabiola Rachid

; Mansur, Letícia Fezer

; Mendes, Maria Fernanda

; Muniz, Andre

; Nobrega Junior, Adaucto W.

; Olival, Guilherme Sciascia do

; Parolin, Monica Fiuza

; Pimentel, Maria Lucia V.

; Rocha, Cristiane Franklin

; Ruocco, Heloisa Helena

; Santos, Gutemberg C.

; Siquineli, Fabio

; Soares, José Otavio D.

; Sousa, Nise Alessandra C.

; Tauil, Carlos Bernardo

; Winckler, Thereza Cristina A.

Arquivos de Neuro-Psiquiatria

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sep 2019, Volume 77 N. 9 Pages 617 - 621

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Enxaqueca piora o sofrimento do paciente que tem esclerose múltipla (EM). ID-migraine é uma ferramenta útil para seleção de pacientes com enxaqueca e Migraine Disability Assessment (MIDAS) é um questionário que avalia o impacto da doença. O objetivo do presente estudo foi avaliar a presença e impacto de enxaqueca em pacientes com EM. Métodos: Pacientes diagnosticados com EM e tratados em clínicas especializadas foram convidados a responder um questionário online se também apresentassem cefaleia. Resultados: O estudo incluiu 746 participantes com cefaleia e EM que preencheram completamente as respostas. Foram 625 mulheres e 121 homens, sendo 69% dos pacientes com idade entre 20 e 40 anos. Enxaqueca foi identificada em 404 pacientes (54,1%) e moderado a grave impacto da doença foi observado em 68,3% dos casos. Conclusão: Enxaqueca é uma cefaleia primária frequente e incapacitante relatada por pacientes com EM.

ABSTRACT Migraine adds to the burden of patients suffering from multiple sclerosis (MS). The ID-migraine is a useful tool for screening migraine, and the Migraine Disability Assessment questionnaire can evaluate disease burden. The aim of the present study was to assess the presence and burden of migraine in patients with MS. Methods: Patients diagnosed with MS attending specialized MS units were invited to answer an online survey if they also experienced headache. Results: The study included 746 complete responses from patients with MS and headache. There were 625 women and 121 men, and 69% of all the patients were aged between 20 and 40 years. Migraine was identified in 404 patients (54.1%) and a moderate-to-high burden of disease was observed in 68.3% of the patients. Conclusion: Migraine is a frequent and disabling type of primary headache reported by patients with MS.

https://doi.org/10.1590/0004-282x20190100 1666 downloads

11.

Serological profile of John Cunningham virus (JCV) in patients with multiple sclerosis
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Branco, Luciana Prats

; Adoni, Tarso

; Apostolos-Pereira, Samira Luisa

; Brooks, Joseph Bruno Bidin

; Correa, Eber Castro

; Damasceno, Carlos Augusto

; Eboni, Audred Cristina Biondo

; Fezer, Leticia

; Gama, Paulo Diniz da

; Goncalves, Marcus Vinicius Magno

; Gomes, Sidney

; Grzesiuk, Anderson Kuntz

; Mendes, Maria Fernanda

; Morales, Rogerio Rizo

; Muniz, Andre

; Parolin, Monica Fiuza Koncke

; Pimentel, Maria Lucia Vellutini

; Ribeiro, Marlise de Castro

; Santos, Gutemberg Augusto Cruz dos

; Sato, Henry Koiti

; Scherpenhuijzen, Simone Batista

; Scorcine, Claudio

; Siquineli, Fabio

; Sousa, Nise Alexandra de Carvalho

; Varela, Daniel Lima

; Winckler, Tereza Cristina Avila

; Fragoso, Yara Dadalti

Arquivos de Neuro-Psiquiatria

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sep 2018, Volume 76 N. 9 Pages 588 - 591

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO As opções terapêuticas para esclerose múltipla (EM) modificaram-se ao longo dos últimos anos, trazendo uma nova categoria de drogas com melhor perfil de eficácia. No entanto, estas drogas vieram com um novo perfil de potenciais eventos adversos que exigem que o neurologista os reconheça bem e rapidamente. Uma das complicações mais temidas destes tratamentos para a EM é a leucoencefalopatia multifocal progressiva (LEMP), causada pela reativação do vírus John Cunningham (JCV). Objetivo: Identificar o perfil sorológico de JCV em pacientes com EM. Métodos: Dados sorológicos de JCV foram obtidos através do ensaio por enzimas imuno-adsorvidas (ELISA) fornecido pelo programa STRATIFY-JCV. Resultados: Um total de 1.501 testes sanguíneos foram obtidos de 1.102 pacientes com EM. O grupo teve 633 pacientes (57,1%) soropositivos para anticorpos anti-JCV e 469 pacientes negativos (42,9%). Vinte e três pacientes se tornaram posivitos após resultados iniciais negativos para anticorpos anti-JCV. A taxa de soroconversão foi 18,5% em 22 meses. Conclusão: O perfil sorológico do JCV e a soroconversão nos pacientes brasileiros foi semelhante àquela descrita em outros países.

ABSTRACT Treatment options for multiple sclerosis (MS) have changed over the last few years, bringing about a new category of drugs with more efficient profiles. However, these drugs have come with a whole new profile of potential adverse events that neurologists have to learn well and quickly. One of the most feared complications of these MS treatments is progressive multifocal leukoencephalopathy caused by the reactivation of the John Cunningham virus (JCV). Objective: To identify the serologic profile of JCV in patients with MS. Methods: Data on serum antibodies for JCV were obtained using the enzyme-linked immunosorbent assay provided by the STRATIFY-JCV program. Results: A total of 1,501 blood tests were obtained from 1,102 patients with MS. There were 633 patients (57.1%) who were positive for antibodies for JCV and 469 patients who were negative (42.9%). Twenty-three patients became positive after initially having negative JCV antibody status. The rate of seroconversion was 18.5% over 22 months. Conclusion: The JCV serologic profile and seroconversion in Brazilian patients were similar to those described in other countries.

https://doi.org/10.1590/0004-282x20180083 3126 downloads

12.

High levels of alexithymia in patients with multiple sclerosis
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Eboni, Audred Cristina Biondo

; Cardoso, Mariana

; Dias, Felipe Moreira

; Gama, Paulo Diniz da

; Gomes, Sidney

; Goncalves, Marcus Vinicius Magno

; Machado, Suzana Costa Nunes

; Nobrega Jr., Adaucto Wanderley da

; Parolin, Monica Fiuza Konke

; Paz, Sonia Castedo

; Ruocco, Heloisa Helena

; Scorcine, Claudio

; Siquineli, Fabio

; Spessotto, Caroline Vieira

; Tauil, Carlos Bernardo

; Fragoso, Yara Dadalti

Dementia & Neuropsychologia

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jun 2018, Volume 12 N. 2 Pages 212 - 215

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Alexitimia é um traço de personalidade caracterizado pelas dificuldades na identificação e descrição dos sentimentos. Alguns pesquisadores descrevem altos índices de alexitimia em pacientes com esclerose múltipla (EM), porém os dados na literatura são escassos. Objetivo: O objetivo do presente estudo foi caracterizar achados de alexitimia em pacientes com EM. Métodos: Este estudo transversal incluiu 180 pacientes com EM e um grupo controle pareado. Dados de pacientes com EM incluíram a duração da doença, número de surtos clínicos de desmielinização e grau de incapacidade neurológica avaliados pela Escala Expandida do Grau de Incapacidade (EDSS). Foram também utilizadas a escala Hospitalar de Ansiedade e Depressão (HAD) e a escala de Alexitimia de Toronto (TAS) foram utilizadas. Resultados: Cada grupo era constituído por 126 mulheres e 54 homens, com mediana de idade de 37 anos e mediana de escolaridade de 16 anos. Pacientes com EM apresentaram maior grau de depressão (p<0.01), ansiedade (p=0.01) e alexitimia (p<0.01) que os controles. Para pessoas com EM, traços depressivos (p<0.01), ansiosos (p=0.03), maior idade (p=0.02), menor nível educacional (p=0.02), maior grau de incapacidade (p<0.01) e o fato de não estar ativamente trabalhando (p=0.03) levaram a maiores níveis de alexitimia. Conclusão: Alexitimia foi um importante achado em pacientes com EM.

Abstract Alexithymia is a personality trait characterized by difficulties identifying and describing feelings. Some researchers describe high levels of alexithymia among patients with multiple sclerosis (MS) but literature data on this subject are scarce. Objective: The objective of the present study was to characterize findings of alexithymia in patients with MS. Methods: This cross-sectional case-control study included 180 patients with MS and a matched control group. Data for patients with MS included disease duration, number of demyelinating relapses and degree of neurological disability, as assessed by the Expanded Disability Scale Score (EDSS). In addition, the Hospital Anxiety and Depression (HAD) scale and the Toronto Alexithymia Scale (TAS) were used. Results: There were 126 women and 54 men in each group, with median age of 37 years and median education of 16 years. Patients with MS had higher degrees of depression (p<0.01), anxiety (p=0.01) and alexithymia (p<0.01) than did control subjects. For individuals with MS, depressive traits (p<0.01), anxious traits (p=0.03), higher age (p=0.02), lower education level (p=0.02), higher degree of disability (p<0.01) and not being actively employed (p=0.03) were associated with higher rates of alexithymia. Conclusion: Alexithymia was a relevant finding in patients with MS.

https://doi.org/10.1590/1980-57642018dn12-020015 1742 downloads

13.

No correlation was observed between vitamin D levels and disability of patients with multiple sclerosis between latitudes 18° and 30° South
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Fragoso, Yara Dadalti

; Adoni, Tarso

; Alves-Leon, Soniza Vieira

; Apostolos-Pereira, Samira L.

; Arruda, Walter Oleschko

; Brooks, Joseph B. Bidin

; Cal, Henrique S. Rodrigues

; Damasceno, Carlos A. Albuquerque

; Gama, Paulo Diniz

; Goncalves, Marcus V. Magno

; Jesus, Carlos A. da Silva de

; Machado, Suzana C. Nunes

; Mansur, Letícia Fezer

; Matta, Andre P. da Cunha

; Mendes, Maria Fernanda

; Morales, Rogerio Rizo

; Nobrega-Jr, Adaucto Wanderley da

; Parolin, Monica K. Fiuza

; Peres, Mario Pietro

; Ribeiro, Marlise de Castro

; Ruocco, Heloisa Helena

; Scherpenhuijzen, Simone

; Siquinelli, Fabio

; Stoney, Patrick N.

; Varela, Daniel Lima

; Eboni, Audred Cristina Biondo

; Spessotto, Caroline Vieira

; Rocha, Elisa Teixeira da

; Lacerda, Pamela Emanuele

Arquivos de Neuro-Psiquiatria

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jan 2017, Volume 75 N. 1 Pages 3 - 8

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Vitamina D assumiu um papel central na pesquisa e tratamento da esclerose múltipla (EM). O objetivo deste estudo foi avaliar os níveis séricos de vitamina D de pacientes com EM e controles que residem em uma área tropical. Métodos: Foram analisados dados de 535 pacientes com EM e 350 indivíduos controle em 14 cidades próximas ao Trópico de Capricórnio. Resultados: O valor médio da determinação de 25-OH vitamina D foi 26,07 ± 10,27 ng/mL para controles e 28,03 ± 12,19 ng/mL para pacientes com EM. Não houve correlação entre os níveis de vitamina D e o grau de incapacidade ao longo da duração da doença. Conclusão: Pelo menos na região que cerca o Trópico de Capricórnio, os níveis séricos de vitamina D estão entre valores de 20 a 30 ng/mL tanto para controles quanto para pacientes com EM.

ABSTRACT Objective: Vitamin D has taken center stage in research and treatment of multiple sclerosis (MS). The objective of the present study was to assess the serum vitamin D levels of a large population of patients with MS and controls living in a restricted tropical area. Methods: Data from 535 patients with MS and 350 control subjects were obtained from 14 cities around the Tropic of Capricorn. Results: The mean serum 25-OH vitamin D level was 26.07 ± 10.27 ng/mL for the control subjects, and 28.03 ± 12.19 ng/mL for patients with MS. No correlation was observed between vitamin D levels and the disability of patients over the disease duration. Conclusion: At least for the region around the Tropic of Capricorn, serum levels of vitamin D typically are within the range of 20 to 30 ng/mL for controls and patients with MS.

https://doi.org/10.1590/0004-282x20160173 3011 downloads

14.

A large outbreak of Legionnaires' Disease in an industrial town in Portugal
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George, Francisco

; Shivaji, Tara

; Pinto, Catia Sousa

; Serra, Luis Antonio Oliveira

; Valente, João

; Albuquerque, Maria João

; Vicêncio, Paula Cristina Olivença

; San-Bento, Ana

; Diegues, Paulo

; Nogueira, Paulo Jorge

; Marques, Teresa

; Rebelo, Helena

; Costa, Filipa

; Rodrigues, Raquel

; Nunes, Alexandra

; Borges, Vitor

; Gomes, João Paulo

; Sampaio, Daniel

; Barreiro, Paula

; Duarte, Silvia

; Carpinteiro, Dina

; Mendonça, Joana

; Silva, Catarina

; Vieira, Luís

; Simões, Maria Joao

; Gonçalves, Paulo

; Nunes, Baltazar

; Dias, Carlos

; Machado, Jorge

; Almeida, Fernando

; Goncalves, Elsa A

; Carvalho, Lucilia

; Viterbo, Pedro

; Jardim, Dilia

; Lacasta, Nuno

; Boavida, Filomena

; Perez, Ana

; Santana, Isabel

; Matias, Paula

; Banza, Nuno

; Rabacal, Carlos

Revista Portuguesa de Saúde Pública

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oct 2016, Volume 34 N. 3 Pages 199 - 208

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Contexto Descrevemos a investigação epidemiológica e medidas de controlo de um surto de doença dos Legionários, ocorrido em Portugal em outubro, novembro e dezembro de 2014. Métodos A definição de caso englobou doentes com critérios clínicos de pneumonia aguda, com provas imagiológicas compatíveis e confirmação laboratorial para a identificação de Legionella pneumophila (L. pneumophila) serogrupo 1, para além do critério epidemiológico de exposição, quer por motivos de residência, ocupacional ou lazer nas freguesias suspeitas. Quarenta e nove possíveis fontes de infeção foram reduzidas a 4 potenciais fontes, após avaliação de risco, todas as indústrias com sistema de torres de arrefecimento. A georreferenciação por residência dos casos e localização de torres permitiu definir 4 áreas de investigação num perímetro de 10 km centrado em cada uma daquelas 4 torres. Comparou-se o número de casos observados com o número de casos esperados, calculados a partir de taxas de ataque do surto aplicadas à população. Usando o teste de Stones, testou-se a razão entre casos observados e casos esperados e declínio do risco em relação à distância de até 10 km em 4 direções. As amostras de L. pneumophila foram comparadas utilizando métodos moleculares. Resultados Foram identificados 403 casos, dos quais 377 foram confirmados, tendo ocorrido 14 óbitos. Os doentes apresentaram sintomas entre 14 de outubro e 2 de dezembro. Em termos meteorológicos, foram registados ventos NE e inversão térmica durante o período estimado de exposição. O risco de doença foi maior em pessoas que vivem a sudoeste de todas as indústrias identificadas, diminuindo com o aumento da distância (p < 0,001). Amostras de 71 dos casos clínicos demonstraram um perfil SBT idêntico às amostras isoladas a partir de uma torre de arrefecimento. A sequência de genoma de L. pneumophila fraseri serogrupo 1 pouco comum como a estirpe causadora do surto confirmou a relação das amostras isoladas. Conclusões Torres de arrefecimento industriais, agentes bacterianos com características mais desenvolvidas para elevada sobrevivência e uma rara combinação de condições climáticas, contribuíram para o segundo maior surto de doença dos Legionários registado na literatura.

Background We describe the investigation and control of an outbreak of Legionnaires' disease in Portugal in October, November and December 2014. Methods Confirmed cases were individuals with pneumonia, laboratory evidence of Legionella pneumophila serogroup 1 and exposure, by residence, occupational or leisure to the affected municipalities. 49 possible sources were reduced to four potential sources, all industries with wet cooling system, following risk assessment. We geo-referenced cases' residences and the location of cooling towers defining four study areas 10 km buffer centered on each cooling tower system. We compared the number of cases with expected numbers, calculated from the outbreak's attack rates applied to 2011 census population. Using Stones' Test, we tested observed to expected ratios for decline in risk, with distance up to 10 km four directions. Isolates of Legionella pneumophila were compared using molecular methods. Results We identified 403 cases, 377 of which were confirmed, 14 patients died. Patients became ill between 14 October and 2 December. A NE wind and thermal inversion were recorded during the estimated period of exposure. Disease risk was highest in people living south west from all of the industries identified and decreased with distance (p < 0.001). 71 clinical isolates demonstrated an identical SBT profile to an isolate from a cooling tower. Whole genome sequencing identified an unusual L. pneumophila subsp. fraseri serogroup 1 as the outbreak causative strain, and confirmed isolates' relatedness. Conclusions Industrial wet cooling systems, bacteria with enhanced survival characteristics and a combination of climatic conditions contributed to the second largest outbreak of Legionnaires' disease recorded internationally.

https://doi.org/10.1016/j.rpsp.2016.10.001 1340 downloads

15.

Patients’ satisfaction with and views about treatment with disease-modifying drugs in multiple sclerosis
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Spessotto, Caroline Vieira

; Cavalli, Hanaie

; Eboni, Audred Cristina Biondo

; Machado, Rafael Berlezi

; Mousquer, Analara Munardi

; Palazzo, Lara Both

; Finkelsztejn, Alessandro

; Goncalves, Marcus Vinicius Magno

; Sato, Henry Koiti

; Siquineli, Fabio

; Fragoso, Yara Dadalti

Arquivos de Neuro-Psiquiatria

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aug 2016, Volume 74 N. 8 Pages 617 - 620

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo O tratamento da esclerose múltipla (EM) com drogas-modificadoras-da-doença (DMDs) está evoluindo e novas drogas estão sendo comercializadas. Eficácia e segurança são aspectos cruciais nas medicações, porém a satisfação do paciente com o tratamento deve ser levada em consideração. Métodos Entrevista individual com pacientes com EM investigando a satisfação e ponto de vista desta população em relação ao tratamento com DMDs. Resultados Cento e vinte e oito pacientes atendidos em unidades especializadas de EM de cinco cidades diferentes foram entrevistados. Mais de 80% dos pacientes estava bastante satisfeito com as medicações utilizadas, considerando aspectos de conveniência de uso e benefício das drogas. O único aspecto que pontuou menos foi tolerabilidade. Conclusão Parâmetros para melhor tratamento de EM devem incluir eficácia, segurança e satisfação dos pacientes com a DMD prescrita.

ABSTRACT Objective The treatment of multiple sclerosis (MS) with disease-modifying-drugs (DMDs) is evolving and new drugs are reaching the market. Efficacy and safety aspects of the drugs are crucial, but the patients’ satisfaction with the treatment must be taken into consideration. Methods Individual interview with patients with MS regarding their satisfaction and points of view on the treatment with DMDs. Results One hundred and twenty eight patients attending specialized MS Units in five different cities were interviewed. Over 80% of patients were very satisfied with the drugs in use regarding convenience and perceived benefits. The only aspect scoring lesser values was tolerability. Conclusion Parameters for improving treatment in MS must include efficacy, safety, and patient satisfaction with the given DMD.

https://doi.org/10.1590/0004-282X20160091 2317 downloads

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