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Monitoramento orientado pela área sob a curva da vancomicina em pacientes pediátricos
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Morales Junior, Ronaldo

; Juodinis, Vanessa D’Amaro

; Santos, Isabela Cristina Pinheiro de Freitas

; Campioni, Camila Canuto

; Wirth, Flávia Gatto de Almeida

; Barbosa, Livia Maria Goncalves

; Souza, Daniela Carla de

; Santos, Silvia Regina Cavani Jorge

Revista Brasileira de Terapia Intensiva

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mar 2022, Volume 34 N. 1 Pages 147 - 153

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Avaliar a probabilidade de atingir o alvo pela razão entre a área sob a curva e a concentração inibitória mínima de vancomicina em pacientes pediátricos após o esquema de dose empírica e demonstrar a aplicabilidade desse método para o monitoramento da vancomicina. Metódos: Foi realizado um estudo de coorte retrospectivo que incluiu pacientes pediátricos com função renal normal internados entre janeiro e dezembro de 2020. O modelo de um compartimento com cinética de primeira ordem foi utilizado para estimar os parâmetros farmacocinéticos, e a área sob a curva foi calculada pela regra do trapézio. O alvo terapêutico foi definido como a razão entre a área sob a curva e a concentração inibitória mínima ≥ 400 e < 600. O teste do qui-quadrado foi aplicado para comparar a probabilidade de atingir o alvo nos grupos etários, enquanto os parâmetros farmacocinéticos foram comparados pelo teste de Kruskal-Wallis com o teste de Dunn para análises post hoc. Consideraram-se significativos os valores de p < 0,05. Resultados: Foram analisados, no total, 42 pares de níveis de vancomicina de 17 pacientes inscritos neste estudo. Após a dose diária empírica de vancomicina, o alvo terapêutico foi atingido em cinco (29%) pacientes; quatro pacientes (24%) apresentavam razão entre a área sob a curva inicial supraterapêutica e o valor de concentração inibitória mínima (> 600mg.h/L) e oito (47%) tinham valores subterapêuticos (< 400mg.h/L). Os patógenos mais identificados foram Staphylococcus spp. (n = 7). Os níveis de vale e as áreas sob a curva mostraram valores moderados de correlação (R2 = 0,73). Um (6%) paciente apresentou lesão renal aguda. Conclusão: A maioria dos pacientes não atingiu o alvo terapêutico com esquema de dose empírica de vancomicina, e a implementação de dosagem baseada na área sob a curva usando duas medições de amostra permitiu ajustes de dose em tempo real com base nos parâmetros farmacocinéticos dos indivíduos.

ABSTRACT Objective: To assess the percentage of vancomycin area under the curve/minimum inhibitory concentration target attainment in pediatric patients after the empirical dose regimen and to demonstrate the applicability of this method for vancomycin monitoring. Methods: A retrospective cohort study was performed including pediatric patients with normal renal function admitted between January 2020 and December 2020. The one-compartment model with first-order kinetics was used to estimate the pharmacokinetic parameters, and the area under the curve was calculated by the trapezoidal rule. The therapeutic target was defined as area under the curve/minimum inhibitory concentration ≥ 400 and < 600. The Chi-squared test was applied to compare the percentage of target attainment over age groups, while the pharmacokinetic parameters were compared by the Kruskal-Wallis test with Dunn’s test for post hoc analyses. We considered significant p-values < 0.05. Results: In total, 42 pairs of vancomycin levels were analyzed from 17 patients enrolled in this study. After empirical vancomycin daily dosing, the therapeutic target was achieved in five (29%) patients; four patients (24%) had a supratherapeutic initial area under the curve/minimum inhibitory concentration value (> 600mg.h/L), and eight (47%) patients had subtherapeutic values (< 400mg.h/L). The most identified pathogens were Staphylococcus spp. (n = 7). Trough levels and areas under the curve showed moderate correlation values (R2 = 0.73). Acute kidney injury occurred in one (6%) patient. Conclusion: Most patients did not reach the therapeutic target with a vancomycin empirical dose regimen, and the implementation of area under the curve-based dosing using two sample measurements allowed for real-time dose adjustments based on individuals’ pharmacokinetic parameters.

https://doi.org/10.5935/0103-507x.20220009-pt

Recomendaciones para el diagnóstico y manejo farmacológico en pacientes pediátricos con infección por SARS-CoV-2 (COVID-19)
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Pavez Azurmendi, Daniela

; González Muñoz, Claudio

; Bernal Ortiz, Fernando

; Pérez Pérez, Regina

; Acuña Ávila, Mirta

; Rosales Chacón, Ruth

; Perillán Torres, José

; Quijarro Santibáñez, Paulina

; Scheu Goncalves, Crhistian

; María Fuenzalida, Luz

; Pérez Godoy, Jorge

; Arancibia, José Miguel

; Impellizzeri, Paula

; Pinto Claude, María Eugenia

Revista chilena de infectología

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dec 2020, Volume 37 N. 6 Pages 625 - 645

Abstract: Es | Text: Es | PDF: Es

319 downloads

Cerebrum-cervical arterial dissection in adults during sports and recreation
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Fragoso, Yara Dadalti

; Adoni, Tarso

; Amaral, Lazaro Luiz Faria do

; Braga, Flavio Tulio

; Brooks, Joseph Bruno Bidin

; Campos, Christiane Siqueira

; Comini-Frota, Elizabeth Regina

; Ferreira, Nelson Paes Fortes Diniz

; Giacon, Luciano Marcus Tirotti

; Gomes, Sidney

; Goncalves, Marcus Vinicius Magno

; Magalhaes, Pedro Silva Correa

; Matta, Andre Palma da Cunha

; Oliveira, Francisco Tomaz Meneses de

; Oliveira, Joao Felipe de

; Pierucettti, Marco Antonio

; Pereira, Samira Luísa dos Apostolos

; Pontes, Maciel Eduardo

; Siquineli, Fabio

; Tauil, Carlos Bernardo

; Troaini, Guilherme Navarro

Arquivos de Neuro-Psiquiatria

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apr 2016, Volume 74 N. 4 Pages 275 - 279

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

A dissecção das artérias cervicais é uma emergência médica. Embora de forma relativamente rara, certas atividades descritas como esportes e recreação podem ser a causa de dissecção arterial independentemente de trauma de crânio ou cervical. O propósito do presente estudo é apresentar uma série de casos de dissecção de artérias cérebro-cervicais em indivíduos durante ou logo após a prática destas atividades desportivas. Métodos Dados retrospectivos de pacientes com dissecção arterial relacionada à prática de esportes e recreação. Resultados Quarenta e um casos foram identificados. A artéria mais frequentemente afetada foi a vertebral. Uma grande variedade de atividades teve relação temporal com a dissecção arterial, sendo a corrida a mais frequente delas. Esta é a maior série de casos da literatura. Conclusão Dissecção arterial pode ser uma complicação da prática de esportes.

Dissection of cervical arteries constitutes a medical emergency. Although relatively rarely, activities classified as sports and recreation may be a cause of arterial dissection independently of neck or head trauma. The purpose of the present paper was to present a series of cases of cerebrum-cervical arterial dissection in individuals during or soon after the practice of these sports activities. Methods Retrospective data on patients with arterial dissection related to sports and recreation. Results Forty-one cases were identified. The most frequently affected vessel was the vertebral artery. A large variety of activities had a temporal relationship to arterial dissection, and jogging was the most frequent of these. This is the largest case series in the literature. Conclusion Arterial dissection may be a complication from practicing sports.

https://doi.org/10.1590/0004-282X20150150 2522 downloads

Qualidade da dieta de adolescentes e fatores associados
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Wendpap, Loiva Lide

; Ferreira, Marcia Goncalves

; Rodrigues, Paulo Rogerio Melo

; Pereira, Rosangela Alves

; Loureiro, Anarlete da Silva

; Goncalves-Silva, Regina Maria Veras

Cadernos de Saúde Pública

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jan 2014, Volume 30 N. 1 Pages 97 - 106

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Analisar a qualidade da dieta de adolescentes pelo Índice de Qualidade da Dieta Revisado (IQD-R) e os fatores associados. Foi realizado estudo transversal com 1.326 adolescentes de escolas públicas e privadas. O consumo alimentar foi obtido utilizando-se questionário de frequência alimentar. Utilizou-se razão de prevalência para avaliar a associação entre o IQD-R elevado (≥ percentil 75) e as variáveis independentes. Variáveis com valor de p <0,20 foram incluídas na regressão de Poisson. A média do IQD-R foi de 75,1 pontos (IC95%: 74,8-75,5). Tempo ≤ 2 horas diárias gasto em atividades sedentárias como assistir televisão, usar computador ou games; tempo ≥ 300 minutos por semana de atividade física e excesso de peso dos adolescentes foram associados a maiores pontuações do IQD-R. Estilo de vida saudável foi associado à dieta de melhor qualidade. Destaca-se a importância do incentivo à prática de atividade física, redução do número de horas diárias em atividades sedentárias e intervenção na prática alimentar dos adolescentes.

The aim of this study was to analyze adolescents’ diet quality and associated factors using the Revised Diet Quality Index (DQI-R). A cross-sectional study was performed with 1,326 adolescents from public and private schools. Food intake was measured using a food frequency questionnaire. Crude prevalence ratio was used to evaluate the association between high DQI-R (≥ 75th percentile) and independent variables. Variables with p-value < 0.20 were included in the Poisson regression analysis. Mean DQI-R was 75.1 points (95%CI: 74.8-75.5). Higher DQI-R scores were associated with ≤ 2 hours per day of sedentary activities (e.g., TV, computer, and videogames), ≥ 300 minutes per week of physical activity, and overweight. Healthy lifestyle was associated with better diet quality. The results emphasize the importance of encouraging physical activity, reducing the number of daily hours in sedentary activities, and intervening in adolescents’ eating habits.

Analizar la calidad de la dieta de los adolescentes por el Índice de Calidad de la Dieta Revisado (ICD-R) y los factores asociados. Fue realizado estudio transversal con 1.326 adolescentes de escuelas públicas y particulares. El consumo alimentario se obtuvo utilizando un cuestionario de frecuencia alimentaria. Se utilizó razón de prevalencia, para evaluar la asociación entre el ICD-R elevado (≥ percentil 75) y las variables independientes. Variables con p-valor < 0,20 fueron incluidas en la regresión de Poisson. El promedio del ICD-R fue de 75,1 puntos (IC95%: 74,8-75,5). Tiempo ≤ 2 horas diarias, utilizado en actividades sedentarias (ver televisión, usar la computadora o vídeo juegos); tiempo ≥ 300 minutos por semana de actividad física y exceso de peso de los adolescentes se asociaron a mayores puntuaciones del ICD-R. Se destaca la importancia del incentivo a la práctica de actividades físicas, reducción del número de horas diarias en actividades sedentarias e intervención en la práctica alimentaria de los adolescentes.

https://doi.org/10.1590/0102-311X00082412 4524 downloads Cited 10 times in SciELO

Early and late oral features of chronic graft-versus-host disease
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Gomes, Alessandra Oliveira Ferrari

; Torres, Sandra Regina

; Maiolino, Angelo

; Santos, Cesar Werneck Noce dos

; Silva Junior, Arley

; Correa, Maria Elvira Pizzigatti

; Moreira, Maria Claudia Rodrigues

; Goncalves, Lucio de Souza

Revista Brasileira de Hematologia e Hemoterapia

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jan 2014, Volume 36 N. 1 Pages 43 - 49

Abstract: En | Text: En | PDF: En

Background: Chronic graft-versus-host disease is a serious complication of allogeneic hematopoietic cell transplantation, and the mouth is one of the affected sites. Objective: The aim of this study was to evaluate the oral features of this disease after hematopoietic cell transplantation. Methods: This was a cross-sectional multicenter study that enrolled patients submitted to transplantation. Oral evaluations used the National Institutes of Health criteria, salivary flow rates, and the range of mouth opening. Pain and xerostomia were evaluated through a visual analogue scale. Patients were divided into two groups based on the transplantation time (up to one year and more than one year). Results: Of the 57 evaluated recipients, 44 had chronic graft-versus-host disease: ten (22.72%) in the group with less than one year after transplantation, and 34 (77.27%) in the group with more than one year after transplantation. Lichenoid/hyperkeratotic plaques, erythematous lesions, xerostomia, and hyposalivation were the most commonly reported oral features. Lichenoid/hyperkeratotic plaques were significantly more common in patients within the first year after the transplant. The labial mucosa was affected more in the first year. No significant changes occurred in the frequency of xerostomia, hyposalivation, and reduced mouth opening regarding time after transplantation. Conclusion: Oral chronic graft-versus-host disease lesions were identified early in the course of the disease. The changes observed in salivary gland function and in the range of mouth opening were not correlated with the time after transplantation.

https://doi.org/10.5581/1516-8484.20140012 1291 downloads

Multiple sclerosis starting before the age of 18 years: the Brazilian experience
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Fragoso, Yara Dadalti

; Ferreira, Maria Lucia Brito

; Morales, Nivea de Macedo Oliveira

; Arruda, Walter Oleschko

; Brooks, Joseph Bruno Bidin

; Carneiro, Denise Sisterolli Diniz

; Carvalho, Margarete de Jesus

; Comini-Frota, Elizabeth Regina

; Correa, Eber Castro

; Damasceno, Carlos Augusto de Albuquerque

; Domingues, Renan Barros

; Finkelsztejn, Alessandro

; Gama, Paulo Diniz da

; Gomes, Sidney

; Goncalves, Marcus Vinicius Magno

; Grzesiuk, Anderson Kuntz

; Khouri, Jussara Mathias Netto

; Kaimen-Maciel, Damacio Ramon

; Mendes, Maria Fernanda

; Morales, Rogerio de Rizo

; Ribeiro, Sonia Beatriz Felix

; Ribeiro, Taysa Alexandrino Gonsalves Jube

; Albuquerque, Livia Brito Bezerra de

; Anacleto, Andrea

; Finkelsztejn, Juliana

; Gama, Rodrigo Assad Diniz da

; Lopes, Josiane

; Oliveira, Celso Luis Silva

; Oliveira, Francisco Tomaz Meneses

; Pires, Leopoldo Antonio

; Saldanha, Patricia Correia de Oliveira

; Souza, Adelia Henriques

; Silva, Alex Eduardo da

Arquivos de Neuro-Psiquiatria

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oct 2013, Volume 71 N. 10 Pages 783 - 787

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Esclerose múltipla (EM) com início na infância e adolescência constitui um desafio para o diagnóstico e manejo da doença. A proposta do presente estudo foi avaliar as características da EM de início precoce em pacientes brasileiros. Métodos Coleta de dados retrospectiva de arquivos de unidades especializadas em atendimento da EM. Resultados A partir de 20 unidades de EM de nove estados brasileiros, foram coletados 117 casos de EM com início antes dos 18 anos de idade. Estes pacientes tinham uma média de 10 anos de duração da doença, de maneira geral apresentavam pouca incapacidade , com um surto a cada dois anos e meio. A média de idade no início da doença era 13,7 anos. Conclusão O presente estudo apresenta uma grande série de casos brasileiros de EM pediátrica. Embora alguns pacientes tenham apresentado forma grave de EM, de maneira geral o grupo de pacientes cuja EM iniciou-se na infância ou adolescência apresentou uma forma relativamente leve da doença no Brasil.

Multiple sclerosis (MS) starting in childhood and adolescence poses a challenge for diagnosis and management of the disease. The aim of the present study was to assess the characteristics of early onset MS in Brazilian patients. Methods Retrospective data collection from specialized MS units. Results From 20 MS units in 11 Brazilian states, 117 cases of MS starting before the age of 18 years were collected. These patients had an average of 10 years of disease duration, still typically with low disability and one relapse every 2.5 years. The mean age for disease onset was 13.7 years. Conclusion The present study introduces a large series of Brazilian cases of pediatric MS. Although some patients presented a very severe form of MS, on the whole the group of patients with MS starting in childhood or adolescence presented a relatively mild form of this disease in Brazil.

https://doi.org/10.1590/0004-282X20130122 4255 downloads Cited 1 time in SciELO

Nearly one-half of Brazilian patients with multiple sclerosis using natalizumab are DNA-JC virus positive
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Fragoso, Yara Dadalti

; Mendes, Maria Fernanda

; Arruda, Walter Oleschko

; Becker, Jefferson

; Brooks, Joseph Bruno Bidin

; Carvalho, Margarete de Jesus

; Comini-Frota, Elizabeth Regina

; Domingues, Renan Barros

; Ferreira, Maria Lucia Brito

; Finkelsztejn, Alessandro

; Gama, Paulo Diniz da

; Gomes, Sidney

; Goncalves, Marcus Vinicius Magno

; Kaimen-Maciel, Damacio Ramon

; Morales, Rogerio de Rizo

; Muniz, Andre

; Ruocco, Heloisa Helena

; Salgado, Pedro Rippel

; Albuquerque, Livia Brito Bezerra de

; Gama, Rodrigo Assad Diniz da

; Georgeto, Sergio

; Lopes, Josiane

; Oliveira, Celso Luis Silva

; Oliveira, Francisco Tomaz Meneses

; Safanelli, Juliana

; Saldanha, Patricia Correia de Oliveira

; Satomi, Massaco

Arquivos de Neuro-Psiquiatria

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oct 2013, Volume 71 N. 10 Pages 780 - 782

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Objetivo Natalizumabe é um tratamento novo e eficaz para esclerose múltipla (EM). O risco constatado de desenvolver leucoencefalopatia multifocal progressiva (LEMP) durante o uso desta droga criou a necessidade de melhor estudar a infecção pelo vírus JC (JCV). O objetivo do presente estudo foi avaliar a prevalência de DNA-JCV em paciente brasileiros usando natalizumabe. Método Detecção qualitativa de JCV no soro foi realizada através de reação em cadeia por polimerase (PCR) em tempo real. Resultados DNA-JCV foi detectado em 86 pacientes (51,2%) de um grupo de 168 pessoas com EM recebendo tratamento com natalizumabe,). Discussão Dados do DNA-JCV no Brasil complementam as avaliações mundiais sobre a prevalência de JCV em pacientes com EM que necessitam tratamento natalizumabe.

Objective Natalizumab is a new and efficient treatment for multiple sclerosis (MS). The risk of developing progressive multifocal leukoencephalopathy (PML) during the use of this drug has created the need for better comprehension of JC virus (JCV) infection. The objective of the present study was to assess the prevalence of JCV-DNA in Brazilian patients using natalizumab. Method Qualitative detection of the JCV in the serum was performed with real-time polymerase chain reaction (PCR). Results In a group of 168 patients with MS who were undergoing treatment with natalizumab, JCV-DNA was detectable in 86 (51.2%) patients. Discussion Data on JCV-DNA in Brazil add to the worldwide assessment of the prevalence of the JCV in MS patients requiring treatment with natalizumab.

https://doi.org/10.1590/0004-282X20130121 3759 downloads Cited 1 time in SciELO

Analysis of the detection coefficient for the association between leprosy and pregnancy in the integration region of Carajas, State of Para, Brazil
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Palacios, Vera Regina da Cunha Menezes

; Bichara, Clea Nazare Carneiro

; Dias, Rodrigo da Silva

; Sousa Junior, Alcines da Silva

; Cardoso, Renan Faria

; Barreiros, Glaubus Vinicius Neves

; Goncalves, Nelson Veiga

Revista da Sociedade Brasileira de Medicina Tropical

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sep 2013, Volume 46 N. 5 Pages 650 - 653

Abstract: En | Text: En | PDF: En

Introduction The association between leprosy and pregnancy is currently poorly understood and has been linked to serious clinical consequences. Methods A retrospective study between 2007 and 2009 was performed in the integration region of Carajás, Brazil on a population of pregnant lepers, with non-lepers of ages 12-49 years serving as the reference population. Results Twenty-nine pregnant lepers were studied during the study period. The detection rates (DRs) for the studied association were 4.7 in 2007, 9.4 in 2008, and 4.3 in 2009. Conclusions The Carajás region presented a medium pattern of endemicity during most of the study period, with a high DR found in 2008.

https://doi.org/10.1590/0037-8682-1459-2013 2148 downloads

PREVALENCE OF HERPES SIMPLEX VIRUS TYPE 2 AND RISK FACTORS ASSOCIATED WITH THIS INFECTION IN WOMEN IN SOUTHERN BRAZIL
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Caldeira, Thais Duquia Moraes

; Goncalves, Carla Vitola

; Oliveira, Gisele Rodrigues de

; Fonseca, Tania Vieira da

; Goncalves, Regina

; Amaral, Clair Teixeira do

; Hora, Vanusa Pousada da

; Martinez, Ana Maria Barral de

Revista do Instituto de Medicina Tropical de São Paulo

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sep 2013, Volume 55 N. 5 Pages 315 - 321

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O vírus herpes simplex tipo 2 (HVS-2) é uma das infecções mais prevalentes em todo o mundo. Considera-se um co-factor na aquisição do vírus da imunodeficiência humana (HIV) e na persistência do papilomavirus humano (HPV). Este estudo tem como objetivo avaliar a prevalência de HSV-2 usando a reação em cadeia da polimerase (PCR) e fatores associados em pacientes atendidos na Universidade Federal do Rio Grande e em Unidades Básicas de Saúde (UBS) do Rio Grande, Brasil. A prevalência de HSV-2 encontrada neste estudo foi de 15,6%. Entre as 302 mulheres estudadas, 158 haviam recebido assistência na UBS e 144 foram atendidos na FURG. A prevalência de HSV-2 nestes grupos foi de 10,8 e 20,8%, respectivamente, com RR: 1,9 e p = 0,012. Conhecer o exame de Papanicolaou, e presença de lesão não teve associação com infecção HSV-2. A análise multivariada mostrou que a variável que influencia no risco de infecção HSV-2 foi o paciente ter HIV, com risco relativo 1,9 e p = 0,04. Discussão: As úlceras genitais são importante porta de entrada para o vírus HIV e o uso do preservativo é estratégia importante para reduzir a transmissão do HIV e do HSV-2.

SUMMARY The herpes simplex virus type 2 (HVS-2) is the most prevalent infection worldwide. It is a cofactor in the acquisition of human immunodeficiency virus (HIV) and the persistence of human papillomavirus (HPV). This study evaluated the prevalence of HSV-2, using the polymerase chain reaction (PCR), and associated factors in patients treated at the Federal University of Rio Grande (FURG) and Basic Health Units (BHU) in Rio Grande, Brazil. The observed prevalence of HSV-2 was 15.6%. Among the 302 women studied, 158 had received assistance in BHU and 144 were treated at FURG. The prevalence of HSV-2 in these groups was 10.8% and 20.8%, respectively, RR 1.9 and p = 0.012. Knowledge about the Pap smear, and the presence of lesions showed no association with HSV-2 infection. Multivariate analysis showed that the variable that most influenced the risk of HSV-2 infection was the presence of HIV infection, with a relative risk of 1.9 and p = 0.04. Discussion: Genital ulcers are an important entry point for HIV, and condom use is an important strategy to reduce transmission of HIV and HSV-2.

https://doi.org/10.1590/S0036-46652013000500004 11570 downloads

10.

Multiple sclerosis in South America: month of birth in different latitudes does not seem to interfere with the prevalence or progression of the disease
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Fragoso, Yara Dadalti

; Adoni, Tarso

; Almeida, Sandra Maria Garcia de

; Alves-Leon, Soniza Vieira

; Arruda, Walter Oleschko

; Barbagelata-Aguero, Fiorella

; Brooks, Joseph Bruno Bidin

; Carra, Adriana

; Claudino, Rinaldo

; Comini-Frota, Elizabeth Regina

; Correa, Eber Castro

; Damasceno, Alfredo

; Damasceno, Benito Pereira

; Diaz, Ethel Ciampi

; Elliff, David George

; Fiore, Ana Patricia Peres

; Franco, Clelia Maria Ribeiro

; Giacomo, Maria Cristina Brandao

; Gomes, Sidney

; Goncalves, Marcus Vinicius Magno

; Grzesiuk, Anderson Kuntz

; Inojosa, Jose Luiz

; Kaimen-Maciel, Damacio Ramon

; Lin, Katia

; Lopes, Josiane

; Lourenco, Gisele Alexandre

; Martinez, Alejandra Diana

; Melcon, Mario Oscar

; Morales, Nivea de Macedo Oliveira

; Morales, Rogerio Rizo

; Moreira, Marcos

; Moreira, Shirlene Vianna

; Oliveira, Celso Luis da Silva

; Oliveira, Francisco Tomaz Menezes de

; Ribeiro, Joao Batista

; Ribeiro, Sonia Beatriz Felix

; Rodriguez, Claudia Carcamo

; Russo, Liliana

; Safanelli, Juliana

; Shearer, Kirsty Deborah

; Siquineli, Fabio

; Vizcarra-Escobar, Darwin

Arquivos de Neuro-Psiquiatria

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sep 2013, Volume 71 N. 9A Pages 573 - 579

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Objetivo Avaliar se o mês de nascimento em diferentes latitudes da América do Sul pode influenciar a presença ou gravidade da esclerose múltipla (EM) na vida. Método Neurologistas de quatro países da América do Sul trabalhando em unidades de EM coletaram os dados de seus pacientes com referência ao mês de nascimento, gênero, idade e progressão da doença. Resultados A análise dos dados mostrou que, para 1207 pacientes com EM e 1207 controles, não havia diferença significativa no mês de nascimento com relação à prevalência de EM em quatro zonas de latitude (0–10; 11–20; 21–30; e 31–40 graus). Não houve relação entre o mês de nascimento e a gravidade da doença em nenhuma destas zonas. Conclusão Os resultados deste estudo mostram que pacientes com EM nascidos de mães grávidas em diferentes latitudes sul não seguem o padrão dos resultados sazonais encontrados nas latitudes norte.

Objective To assess whether the month of birth in different latitudes of South America might influence the presence or severity of multiple sclerosis (MS) later in life. Methods Neurologists in four South American countries working at MS units collected data on their patients' month of birth, gender, age, and disease progression. Results Analysis of data from 1207 MS patients and 1207 control subjects did not show any significant variation in the month of birth regarding the prevalence of MS in four latitude bands (0–10; 11–20; 21–30; and 31–40 degrees). There was no relationship between the month of birth and the severity of disease in each latitude band. Conclusion The results from this study show that MS patients born to mothers who were pregnant at different Southern latitudes do not follow the seasonal pattern observed at high Northern latitudes.

https://doi.org/10.1590/0004-282X20130098 4911 downloads Cited 2 times in SciELO

11.

Leprosy and pregnancy in the State of Para: an epidemiological perspective
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Palacios, Vera Regina da Cunha Menezes

; Bichara, Clea Nazare; Carneiro

; Silva Junior, Jarbas Barbosada

; Dias, Rodrigo da Silva

; Goncalves, Nelson Veiga

Revista da Sociedade Brasileira de Medicina Tropical

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jul 2013, Volume 46 N. 4 Pages 453 - 460

Abstract: En | Text: En | PDF: En

Introduction A few older publications describe leprosy associated with pregnancy, a situation that has been linked to leprosy exacerbation. This study aimed to describe the detection rate of this association in the State of Pará by county and Integration Region (IR) from 2007 to 2009 via an analysis of sociodemographic, epidemiological and operational indices. Methods This was a descriptive study using information generated by the SINAN. The Detection Coefficient of the Leprosy and Pregnancy Association (DCLP) epidemiological index was constructed to help interpret the endemicity parameters. The disease was considered hyperendemic when greater than two cases per 10,000 inhabitants were identified. Results During the study period, 149 associations were detected, with 14 hyperendemic counties: seven in 2007, five in 2008 and two in 2009. The Carajás Integrated Region displayed the highest DCLP index in the period. Eldorado dos Carajás had the single highest DCLP index (5.7/10,000 inhabitants, 2008), whereas the DCLP index in Conceição do Araguaia was very high in all three years. However, most counties displayed low or medium DCLP indices. The annual averages were 0.31 DCLP (2007), bass; 0.30 (2008), bass and 0.19 (2009), bass. The average DCLP index was 0.26, which is considered low. Three clusters of medium endemicity were identified by the average DCLP in the study period. Conclusions The analyses indicated that the surveillance program is still unsatisfactory in Pará. The interpretation of the endemicity parameters enabled qualitative and quantitative analyses to determine the epidemiological panorama of this association. The identification of high endemicity requires further clarification.

https://doi.org/10.1590/0037-8682-0019-2013 2979 downloads

12.

Estimativa da deterioração da madeira de assoalho de prédio histórico por meio de ondas ultrassônicas
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Gatto, Darci Alberto

; Goncalves, Margarete Regina Freitas

; Mattos, Bruno Dufau

; Calegari, Leandro

; Stangerlin, Diego Martins

CERNE

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dec 2012, Volume 18 N. 4 Pages 651 - 656

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Esse trabalho apresentou como objetivo detectar o grau externo de deterioração da madeira de Araucaria angustifolia (Bert.) O. Kuntze utilizada na confecção de assoalho. Para isso, foram testados os métodos visuais, por meio de notas, e o método não destrutivo baseado na propagação de ondas ultrassônicas. Comparando-se a velocidade de propagação de ondas ultrassônicas na madeira sadia e na madeira atacada verificou-se que as mesmas diferenciavam entre si ao nível de 5% de erro. Verificou-se também que o aumento na proporção de ataque na madeira apresentou-se inversamente proporcional à velocidade de propagação da onda. Uma vez que as amostras foram avaliadas apenas nas suas faces superficiais, fazem-se necessários estudos adicionais a fim de avaliar a influência dos defeitos internos das peças de madeira na velocidade ultrassônica.

This study aimed to detect the external degree of decay of Araucaria angustifolia (Bert.) O. Kuntze wood used in flooring. The visual method through grades and the non-destructive method based on the propagation of ultrasound waves were applied. The comparison between the propagation velocity of ultrasonic waves on clear wood and decayed wood showed statistical difference at the 5% level. Moreover, the proportion of decay wood was inversely proportional to the velocity of propagation. The samples were evaluated only on their superficial faces, therefore additional studies to assess the influence of the wood internal defects in the ultrasonic velocity are necessary.

2161 downloads Cited 1 time in SciELO

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