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Global DNA methylation patterns in Alcohol Use Disorder
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Schuch, Jaqueline B.

; Bandeira, Cibele E.

; Junior, Jorge L. S.

; Müller, Diana

; Charão, Mariele F.

; Silva, Bruna S. da

; Grevet, Eugenio H.

; Kessler, Felix H. P.

; von Diemen, Lisia

; Rovaris, Diego L.

; Bau, Claiton H. D.

Genetics and Molecular Biology

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2023, Volume 46 N. 3 elocation e20230139

Abstract: En | Text: En | PDF: En

Abstract Alcohol Use Disorder (AUD) is a highly prevalent condition worldwide that produces a wide range of pathophysiological consequences, with a critical impact on health and social issues. Alcohol influences gene expression through epigenetic changes mainly through DNA methylation. In this sense, levels of 5-methylcytosine (5-mC), namely Global DNA methylation (GMe), which can be influenced by environmental and hormonal effects, represent a putative biological mechanism underlying alcohol effects. Our aim was to investigate the influence of AUD diagnosis and alcohol patterns (i.e., years of addiction, use in the last 30 days, and alcohol severity) on GMe levels. The sample consisted of 256 men diagnosed with AUD and 361 men without AUD. DNA samples from peripheral blood were used to assess GMe levels, measured through the levels of 5-mC using high-performance liquid chromatography. Results from multiple linear regression analysis indicated that the presence of AUD was associated with lower GMe levels (beta=-0.155, p=0.011). Other alcohol-related outcomes were not associated with DNA methylation. Our findings are consistent with the hypothesis that the impact of chronic and heavy alcohol use in GMe could be a potential mechanism mediating the multiple organ damages related to AUD.

https://doi.org/10.1590/1678-4685-gmb-2023-0139

Attention-deficit/hyperactivity disorder and brain metabolites from proton magnetic resonance spectroscopy: a systematic review and meta-analysis protocol
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Vidor, Marcos Vinícius

; Panzenhagen, Alana Castro

; Martins, Alexandre Ribeiro

; Cupertino, Renata Basso

; Bandeira, Cibele Edom

; Rohde, Luis Augusto

; Rovaris, Diego Luiz

; Bau, Claiton Henrique Dotto

; Grevet, Eugênio Horácio

Trends in Psychiatry and Psychotherapy

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mar 2021, Volume 43 N. 1 Pages 1 - 8

Abstract: En | Text: En | PDF: En

Abstract Despite major advances in the study of the brain, investigations on neurochemistry in vivo still lack the solid ground of more established methods, such as structural and functional magnetic resonance imaging. Proton magnetic resonance spectroscopy (MRS) is a technique that might potentially fill in this gap. Nevertheless, studies using this approach feature great methodological heterogeneity, such as varying voxel of choice, differences on emphasized metabolites, and absence of a standardized unit. In this study, we present a methodology for creating a systematic review and meta-analysis for this kind of scientific evidence using the prototypical case of attention-deficit/hyperactivity disorder. Systematic review registration: International Prospective Register of Systematic Reviews (PROSPERO), CRD42018112418.

https://doi.org/10.47626/2237-6089-2019-0111 364 downloads

Supporting people with severe mental health conditions during the COVID-19 pandemic: considerations for low- and middle-income countries using telehealth case management
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Salum, Giovanni A.

; Rehmenklau, Jaqueline F.

; Csordas, Michele C.

; Pereira, Flavia P.

; Castan, Juliana U.

; Ferreira, Anderson B.

; Delgado, Vera B.

; Bolzan, Liana de M.

; de Lima, Miguel A.

; Blauth, Juarez H.

; dos Reis, José R.

; Rocha, Paula B.

; Guerra, Tadeu A.

; Saraiva, Izabela M.

; Gramz, Bruna de C.

; Ronchi, Bruna R.

; Ribeiro, Bruna L.

; Konig, Dienifer F.

; Grevet, Eugênio H.

; de Pinho, Leandro B.

; Schneider, Jacó F.

; Eustáquio, Paula R.

; Ramos, Márcia Z.

; Marques, Myriam F.

; Axelrud, Luiza K.

; Baeza, Fernanda L.

; Lacko, Sara E.

Brazilian Journal of Psychiatry

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aug 2020, Volume 42 N. 4 Pages 451 - 452

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/1516-4446-2020-1078 1141 downloads

Transtorno de oposição e desafio e transtorno de conduta: os desfechos no TDAH em adultos
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Grevet, Eugenio Horacio

; Salgado, Carlos Alberto Iglesias

; Zeni, Gregory

; Belmonte-de-Abreu, Paulo

Jornal Brasileiro de Psiquiatria

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2007, Volume 56 Suppl. 1 Pages 34 - 38

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Os autores examinam a influência dos transtornos de oposição e desafio (TOD), de conduta (TC) e de personalidade anti-social (TPAS) ao longo da vida do indivíduo com TDAH. Os principais achados mostram que o TDAH é modulado por essas comorbidades e que seu prognóstico é modificado dependendo da presença ou não desses transtornos. O transtorno de oposição e desafio intensificaria as características de impulsividade e isolacionismo do TDAH, porém não acarretaria em um aumento na incidência de TPAS na vida adulta. Já o TC associado ao TDAH implica um aumento significativo na impulsividade e agressividade, estando associado significativamente a TPAS e um pior prognóstico. A diferenciação entre os diferentes transtornos e seu correto diagnóstico é essencial para o tratamento adequado do TDAH. Futuros estudos precisam determinar se o tratamento do TDAH produziria uma mudança significativa no prognóstico desse grupo de pacientes.

The authors examine the influence of oppositional defiant disorder (ODD), conduct disorder (CD) and anti-social personality disorder (ASPD) on attention deficit/hyperactivity disorder (ADHD) across life span. The findings showed that ADHD is modulated by this comorbidities and ADHD prognosis is modified depending on the presence or the absence of those disorders. ODD intensifies ADHD impulsivity and isolationism, but does not lead to an increase in the prevalence of ASPD in adulthood. Otherwise, CD associated with ADHD increases significantly the levels of impulsivity and aggressiveness, is associated with ASPD and a poor outcome. The appropriate approach to ADHD must be based on the correct diagnosis of different comorbidities to predict the outcomes. Further studies are needed to investigate if the treatment of ADHD can produce a significant improvement on the outcomes of this group of patients.

53564 downloads Cited 1 time in SciELO

Painel brasileiro de especialistas sobre diagnóstico do transtorno de déficit de atenção/hiperatividade (TDAH) em adultos
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Mattos, Paulo

; Palmini, André

; Salgado, Carlos Alberto

; Segenreich, Daniel

; Grevet, Eugênio

; Oliveira, Irismar Reis de

; Rohde, Luiz Augusto

; Romano, Marcos

; Louzã, Mário

; Abreu, Paulo Belmonte de

; Lima, Pedro Prado

Revista de Psiquiatria do Rio Grande do Sul

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apr 2006, Volume 28 N. 1 Pages 50 - 60

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Considerando-se as dificuldades atuais do diagnóstico do transtorno do déficit de atenção/hiperatividade em adultos, foram reunidos especialistas brasileiros que fazem pesquisas nesta área, de modo a produzir diretrizes de consenso para uso no país. Foi realizada uma revisão não-sistemática preliminar e concebido um texto inicial, que foi repetidamente avaliado e editado pelos autores, com acréscimos e correções ao longo de 6 meses, através de correio eletrônico e de uma reunião posterior, patrocinada pela Associação Brasileira do Déficit de Atenção. A versão preliminar foi apresentada publicamente durante o congresso anual da Associação Brasileira de Psiquiatria, com comentários e sugestões dos participantes, para a redação da versão final.

Present difficulties in the diagnosis of attention-deficit/hyperactivity disorder in adults have prompted Brazilian specialists involved in research in this area to make a consensus to be used in the country. A non-systematic preliminary review was repeatedly evaluated by all authors, who added new material, commented and corrected parts of the text for 6 months through electronic mail and a further meeting sponsored by the Brazilian Association of Attention-Deficit Disorder. The preliminary version was publicly presented during the annual congress of the Associação Brasileira de Psiquiatria (Brazilian Association for Psychiatry) for appraisal and suggestions from participants in order to prepare the final version.

Considerándose las dificultades actuales del diagnóstico del trastorno del déficit de atención/hiperactividad en adultos, se reunieron especialistas brasileños que investigan en esa área, de modo a producir directrices de consenso para uso en el país. Se realizó una revisión no-sistemática preliminar y se concibió un texto inicial, que ha sido repetidamente evaluado y editado por los autores, con acrecimos y correcciones a lo largo de 6 meses, a través de correo electrónico y de una reunión posterior, patrocinada por la Asociación Brasileña del Déficit de Atención. La versión preliminar ha sido presentada públicamente durante el congreso anual de la Asociación Brasileña de Psiquiatría, con comentarios y sugerencias de los participantes para la redacción de la versión final.

41582 downloads Cited 11 times in SciELO

Concordância entre observadores para o diagnóstico em adultos do trantorno de déficit de atenção/hiperatividade e transtorno de oposição desafiante utilizando o K-SADS-E
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Grevet, Eugenio Horácio

; Bau, Claiton Henrique Dotto

; Salgado, Carlos Alberto Iglesias

; Ficher, Aline

; Victor, Marcelo Moraes

; Garcia, Christiane

; Sousa, Nyvia Oliveira de

; Nerung, Luciana

; Belmonte-de-Abreu, Paulo

Arquivos de Neuro-Psiquiatria

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jun 2005, Volume 63 N. 2a Pages 307 - 310

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O diagnóstico do transtorno de déficit de atenção e hiperatividade (TDAH) e do transtorno de oposição desafiante (TOD) em adultos carece de instrumentos adequados. Esta investigação visa avaliar a confiabilidade entre observadores das seções do K-SADS-E adaptadas para os diagnósticos destes transtornos em adultos. As adaptações realizadas se limitaram ao direcionamento das perguntas ao próprio paciente, investigação do início dos sintomas em um período mais tardio e abordagem de sintomas próprios de adultos. Seis avaliadores treinados pontuaram 16 entrevistas gravadas. Os coeficientes Kappa foram de 1,00 para o diagnóstico de TDAH no passado, 0,91 para o subtipo no passado, 1,00 para diagnóstico de TDAH atual e 0,95 para o subtipo atual. Os coeficientes Kappa para o TOD foram de 1,00 para o diagnóstico no passado e 0,89 para o diagnóstico atual. Todos os coeficientes tiveram um p<0,001. Os resultados demonstram excelente concordância para os diagnósticos de TDAH e TOD em adultos utilizando a forma adaptada da versão em português do K-SADS-E.

The diagnosis of attention deficit hyperactivity disorder (ADHD) and oppositional defiant disorder (ODD) in adults lacks adequate assessment instruments. The aim of this investigation is to evaluate the interrater reliability of the sections of K-SADS-E adapted for the diagnosis of these disorders among adults. The adaptations were limited to asking questions directly to the patient, investigation of a later onset of symptoms, and asking for adult specific symptoms. Six trained raters scored 16 recorded interviews. Kappa coefficients were 1.00 for ADHD diagnosis in the past, 0.91 for subtype in the past, 1.00 for ADHD diagnosis in the present, 0.95 for subtype in the present, 1.00 and 0.89 for ODD diagnosis in the past and present, respectively (all with p<0.001). These results reveal excellent agreement for the ADHD and ODD diagnosis in adults using the adapted form of the Portuguese version of K-SADS-E.

7078 downloads Cited 3 times in SciELO

Terapia cognitivo-comportamental na prática clínica
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Grevet, Eugenio Horácio

Revista de Psiquiatria do Rio Grande do Sul

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aug 2004, Volume 26 N. 2 Pages 226 - 227

Abstract: Pt | Text: Pt | PDF: Pt

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Proposta de uma abordagem psicoeducacional em grupos para pacientes adultos com Transtorno de Déficit de Atenção/Hiperatividade
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Grevet, Eugenio Horácio

; Abreu, Paulo Belmonte de

; Shansis, Flávio

Revista de Psiquiatria do Rio Grande do Sul

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dec 2003, Volume 25 N. 3 Pages 446 - 452

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Os autores do presente artigo propõem, a partir do modelo pedagógico proposto por Antoni Zabala, uma abordagem psicoeducativa grupal para pacientes adultos portadores de Transtorno de Déficit de Atenção/Hiperatividade. Para tanto, adaptam esta estrutura pedagógica para fundamentar a abordagem de grupos psicoeducacionais. O presente trabalho adiciona uma nova técnica para o tratamento do TDAH no adulto a partir da interface entre a pedagogia e a psicoterapia.

TIn this paper the authors suggest a psycho-educative group approach to adult patients with Attention Deficit/Hyperactivity Disorder (ADHD) based on a pedagogic model proposed by Antoni Zabala. This paper intends to present this new technique for the treatment of adults with ADHD. The conceptualization is based on the interface between pedagogy and psychotherapy.

Los autores del presente artículo proponen, a partir del modelo pedagógico propuesto por Antoni Zabala, un abordaje psico-educativo grupal para pacientes adultos portadores del Tratamiento del Déficit de Atención/Hiperactividad. Para tanto, adaptan esta estructura pedagógica para fundamentar el abordaje de grupos psico-educacionales. El presente trabajo adiciona una nueva técnica para el tratamiento del TDAH en el adulto a partir de la interfase entre la pedagogía y la psicoterapia.

17331 downloads Cited 5 times in SciELO

Development and application of the mania rating guide (MRG)
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Shansis, Flávio

; Grevet, Eugênio

; Mattevi, Betina

; Berlim, Marcelo

; Maldonado, Gabriela

; Santin, Aida

; Fleck, Marcelo

; Izquierdo, Iván

Brazilian Journal of Psychiatry

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jun 2003, Volume 25 N. 2 Pages 91 - 95

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

No presente artigo, são apresentados o desenvolvimento e a aplicação de uma entrevista semi-estruturada, denominada Guia para Avaliação do Estado Maníaco (GAEM). Esse foi elaborado para auxiliar no preenchimento de três escalas de mania: Mania Rating Scale, Bech-Rafaelsen Mania Scale e Clinician-Administered Rating Scale for Mania. O GAEM é formado por vinte e uma Dimensões Psicopatológicas, que correspondem aos Itens das Escalas originais, estruturados na forma de Questões. O Guia foi aplicado em quinze pacientes bipolares em fase maníaca, admitidos na Unidade de Internação Psiquiátrica do Hospital de Clínicas de Porto Alegre. Um psiquiatra os entrevistou utilizando o GAEM, sendo que as entrevistas foram filmadas. Posteriormente, três avaliadores independentes pontuaram as Escalas de Mania a partir das filmagens. A impressão dos avaliadores foi a de que o GAEM permite não só pontuar facilmente todos os Itens das Escalas, como também abarcar o grande espectro da apresentação sintomatológica de uma síndrome maníaca.

In this article we present the development and application of the Mania Rating Guide (MRG), a semi-structured interview. This guide was created in order to assist the filling of three mania Scales: Mania Rating Scale, Bech-Rafaelsen Mania Scale and Clinician-Administered Rating Scale for Mania. The MRG consists of twenty-one Psychopathological Dimensions, that correspond to the Items of the original Scales, and are structured in Questions. The guide was applied to fifteen manic patients admitted in the Psychiatric Unit of the Clinical Hospital of Porto Alegre. A psychiatrist interviewed them using the MRG, and the interviews were videotaped. Afterwards, three independent raters scored the Mania scales based on the films. The impression of the raters was that the MRG allows not only to easily score all the Items of the Scales but also to cover the wide spectrum of the symptomatological presentation of a manic syndrome.

3788 downloads Cited 1 time in SciELO

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