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au:HUSSEIN, M.S.

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Coenzyme Q10 and pro-inflammatory markers in children with Down syndrome: clinical and biochemical aspects
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Zaki, Moushira E.

; El-Bassyouni, Hala T.

; Tosson, Angie M.S.

; Youness, Eman

; Hussein, Jihan

Jornal de Pediatria

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feb 2017, Volume 93 N. 1 Pages 100 - 104

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo: Objetivo: Foram relatadas evidências de estresse oxidativo em indivíduos com a síndrome de Down. Há um interesse cada vez maior na contribuição do sistema imunológico na síndrome de Down. O objetivo deste estudo é avaliar a coenzima Q10 e marcadores pró-inflamatórios selecionados, como interleucina 6 e o fator de necrose tumoral α, em crianças com a síndrome de Down. Métodos: Foram inscritas neste estudo de caso-controle 86 crianças (5-8 anos) de duas instituições públicas. No momento da amostragem, os pacientes e os controles não sofriam de doença aguda ou crônica e não recebiam terapia ou suplementos. Foram medidos os níveis de interleucina 6, fator de necrose tumoral α, coenzima Q10, glicemia de jejum e quociente de inteligência. Resultados: Foram incluídas em oito meses (janeiro-agosto 2014) 43 crianças com síndrome de Down e 43 controles. Em comparação com o grupo de controle, os pacientes com síndrome de Down mostraram aumento significativo na interleucina 6 e no fator de necrose tumoral α (p = 0,002), ao passo que a coenzima Q10 apresentou significativa redução (p = 0,002). Além disso, o índice de massa corporal e a glicemia de jejum eram significativamente maiores nos pacientes. Houve uma correlação significativamente positiva entre os níveis de coenzima Q10 e do quociente de inteligência, bem como entre a interleucina 6 e o fator de necrose tumoral α. Conclusão: Os níveis de interleucina 6 e o fator de necrose tumoral α em crianças mais novas com síndrome de Down podem ser usados como biomarcadores, refletem o processo neurodegenerativo neles. A coenzima Q10 pode ter um papel como bom suplemento em crianças com síndrome de Down para melhorar os sintomas neurológicos.

Abstract: Objective: Evidence of oxidative stress was reported in individuals with Down syndrome. There is a growing interest in the contribution of the immune system in Down syndrome. The aim of this study is to evaluate the coenzyme Q10 and selected pro-inflammatory markers such as interleukin 6 and tumor necrosis factor α in children with Down syndrome. Methods: Eighty-six children (5-8 years of age) were enrolled in this case-control study from two public institutions. At the time of sampling, the patients and controls suffered from no acute or chronic illnesses and received no therapies or supplements. The levels of interleukin 6, tumor necrosis factor α, coenzyme Q10, fasting blood glucose, and intelligence quotient were measured. Results: Forty-three young Down syndrome children and forty-three controls were included over a period of eight months (January-August 2014). Compared with the control group, the Down syndrome patients showed significant increase in interleukin 6 and tumor necrosis factor α (p = 0.002), while coenzyme Q10 was significantly decreased (p = 0.002). Also, body mass index and fasting blood glucose were significantly increased in patients. There was a significantly positive correlation between coenzyme Q10 and intelligence quotient levels, as well as between interleukin 6 and tumor necrosis factor α. Conclusion: Interleukin 6 and tumor necrosis factor α levels in young children with Down syndrome may be used as biomarkers reflecting the neurodegenerative process in them. Coenzyme Q10 might have a role as a good supplement in young children with Down syndrome to ameliorate the neurological symptoms.

https://doi.org/10.1016/j.jped.2016.04.012 5774 downloads

Quasiparticle-rotor model description of carbon isotopes
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Tarutina, T.

; Samana, A.R.

; Krmpotic, F.

; Hussein, M.S.

Brazilian Journal of Physics

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dec 2006, Volume 36 N. 4b Pages 1349 - 1353

Abstract: En | Text: En | PDF: En

In this work we perform quasiparticle-rotor coupling model calculations within the usual BCS and the projected BCS for the carbon isotopes 15C, 17C and 19C using 13C as the building block. Owing to the pairing correlation, we find that 13C as well as the cores of the other isotopes, namely 14C, 16C and 18C acquire strong and varied deformations. The deformation parameter is large and negative for 12C, very small (or zero) for 14C and large and positive for 16C and 18C. This finding casts a doubt about the purity of the supposed simple one-neutron halo nature of 19C.

1295 downloads

Técnicas e construções de ensembles de matrizes aleatórias e estatísticas correlatas
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Bertuola, A.C.

; Hussein, M.S.

; Pato, M.P.

Revista Brasileira de Ensino de Física

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2006, Volume 28 N. 3 Pages 333 - 340

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Apresentamos neste artigo duas construções distintas do ensemble ortogonal gaussiano. Para tornar esse trabalho mais didático, usamos as matrizes de ordem dois. Dessa forma, obtivemos analiticamente: a distribuição das matrizes, a distribuição de um elemento da matriz, a distribuição dos espaçamentos, a distribuição de uma componente de um autovetor e a densidade de estados. Para confirmar os cálculos, apresentamos as simulações numéricas.

In this paper we present two distinct constructions of the gaussian orthogonal ensemble. For didactic purposes we consider matrices of dimension 2. In this manner we obtain analytical results for the distribution of the elements of the matrices, the spacing, one component of the wave functions and also the density of states. We compare our analytical results with numerical simulations.

1618 downloads

O oscilador harmônico amortecido forçado revisitado
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Bertuola, A.C.

; Hussein, M.S.

; Pato, M.P.

Revista Brasileira de Ensino de Física

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sep 2005, Volume 27 N. 3 Pages 327 - 332

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Neste artigo, pretendemos apresentar as aulas sobre o oscilador harmônico amortecido forçado, usando um método geral, para se obter as soluções de equações diferenciais de segunda ordem, não homogêneas. Desta forma, essa contribuição servirá como uma forma de modernizar o tratamento dado em textos conhecidos como os de Symon e Marion. Ele serve também como material didático para alunos do curso de Mecânica I, no segundo ano da graduação do curso de bacharelado em Física. Sugerimos aos alunos interessados que efetuem todos os cálculos passo a passo, para uma melhor compreensão deste trabalho.

In this article, we present ''lectures" about the well-know mechanics problem of a forced damped harmonic oscillator. We use the general method of solving second-order linear, non-homogenous, differential equation. In this fashion our contribuition here should serve to "modernize" the usual textbook treatments of this problem. These lectures can be presented to second year undergraduate students of physics. We suggest that the students go through all the steps used in the derivations.

7233 downloads

Residual nucleus excitation energy in (e, e'p): reaction
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Likhachev, V. P.

; Arruda-Neto, J. D. T.

; Cruz, M.T.F. da

; Dias, H.

; Duarte, S.B.

; Carvalho Jr, W.R.

; Hussein, M.S.

; Lima, A.C.S.

; Macedo, L.F.R.

; Mesa, J.

; Pashchuk, S.A.

; Rodrigues, T.E.

; Silva, G.

; Schelin, H.R.

; Tavares, O.A.P.

Brazilian Journal of Physics

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sep 2004, Volume 34 N. 3a Pages 753 - 755

Abstract: En | Text: En | PDF: En

The propagation of the struck proton through the nuclear medium is studied in the semi-classical multicolli-sional internuclear cascade approach. The probability of formation of various residual nucleus configurations and the corresponding excitation energies were obtained as a function of the energy omega transferred to the proton by the knockout.

1469 downloads

Semiclassical Coulomb excitation matrix elements
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Carlson, B.V.

; Canto, L.F.

; Hussein, M.S.

Brazilian Journal of Physics

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sep 2004, Volume 34 N. 3a Pages 859 - 861

Abstract: En | Text: En | PDF: En

Coulomb excitation matrix elements are often expressed in terms of the scalar electric potential and the electromagnetic fields. We show that, through an appropriate gauge transformation, the excitation matrix elements can always be expressed in terms of the electromagnetic fields alone. This change in representation becomes important when the widths of the excited states are taken into account.

1063 downloads

Schematic coupled-channel calculations for nuclear reactions with unstable beams
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Cárdenas, W.H.Z.

; Canto, L.F.

; Donangelo, R.

; Carlin, N.

; Hussein, M.S.

Brazilian Journal of Physics

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sep 2004, Volume 34 N. 3b Pages 1254 - 1264

Abstract: En | Text: En | PDF: En

We study nuclear reactions in collisions of unstable projectiles with heavy targets. For this purpose, we use a simple approximation for the breakup channel and treat two-neutron halos as a single particle. We then evaluate cross sections for collisions of 6He projectiles with targets of 238U and 209Bi. Comparing our results with recently measured fusion cross sections, we conclude that the large enhancement observed in 6He+238U fusion at sub-barrier energies cannot be explained by the coupling with the breakup channel. The effects of the halo on other reaction channels are also investigated. Coulomb-nuclear interference in the breakup channel is discussed.

2177 downloads

Fragmentation of exotic oxygen isotopes
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Leistenschneider, A.

; Aumann, T.

; Boretzky, K.

; Canto, L.F.

; Carlson, B.V.

; Cortina, D.

; Datta Pramanik, U.

; Elze, Th.W.

; Emling, H.

; Geissel, H.

; Grünschloss, A.

; Helariutta, K.

; Hellström, M.

; Hussein, M.S.

; Ilievski, S.

; Jones, K.

; Kratz, J.V.

; Kulessa, R.

; Le Hong, Khiem

; Lubkiewicz, E.

; Münzenberg, G.

; Palit, R.

; Reiter, P.

; Scheidenberger, C.

; Schmidt, K.-H.

; Simon, H.

; Sümmerer, K.

; Wajda, E.

; Walús, W.

Brazilian Journal of Physics

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jun 2003, Volume 33 N. 2 Pages 328 - 332

Abstract: En | Text: En | PDF: En

Abrasion-ablation models and the empirical EPAX parametrization of projectile fragmentation are described. Their cross section predictions are compared to recent data of the fragmentation of secondary beams of neutron-rich, unstable 19,20,21O isotopes at beam energies near 600 MeV/nucleon as well as data for stable 17,18O beams.

1215 downloads

Radioactive ion beams in Brasil (RIBRAS)
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Lichtenthäler, R.

; Lépine-Szily, A.

; Guimarães, V.

; Lima, G.F.

; Hussein, M.S.

Brazilian Journal of Physics

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jun 2003, Volume 33 N. 2 Pages 294 - 296

Abstract: En | Text: En | PDF: En

The study of the so called exotic nuclei constitutes an important field of research in nuclear physics. The possibility of producing secondary beams of unstable nuclei(RIB) allows the investigation of nuclei at extreme conditions as low binding energies, high angular momentum and isospin. More laboratories are going through the process of re-direction of their experimental effort towards this activity. The nuclear physics community in Brazil has enthusiastically decided to join this endeavor to provide the Pelletron/LINAC complex with two superconducting solenoids which will permit the production of secondary beams of radioactive nuclei. A description of this facility and project RIBRAS follows.

1342 downloads

10.

Gravity Effects on Nuclear Reactions at Low Energies
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Hussein, M.S.

; Lichtenthäler Fo, R.

; Pato, M.P.

; Bertulani, C.A.

Brazilian Journal of Physics

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dec 1997, Volume 27 N. 4 Pages 464 - 467

Abstract: En | Text: En | PDF: En

We consider the effect of the Earth gravitational attraction on nuclear reactions at very low energies. In particular, the Mott oscillation characteristic of scattering of two identical nuclei is found to be slightly but significantly modified. The effect discussed here is different but complementary to the COW effect in cold neutron interferometry. We take as an example 208Pb+208Pb. An angle precision of about 10-3 deg. is required to detect the effect.

1704 downloads

11.

Inverse Dynamics in the Classical Fermi Accelerator
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Hussein, M.S.

; Pato, M.P.

; Kharchenko, V.

Brazilian Journal of Physics

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dec 1997, Volume 27 N. 4 Pages 492 - 498

Abstract: En | Text: En | PDF: En

The motion of a particle constrained to move between two walls one of which is moveable is solved. We determine analytically the effective forces that act on the particle or on the moveable wall. The quantal version of the solution is briefly discussed.

1009 downloads

12.

Uniform Expansion of the Thermonuclear Reaction Rate Formula
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Hussein, M.S.

; Pato, M.P.

Brazilian Journal of Physics

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sep 1997, Volume 27 N. 3

Abstract: En | Text: En | PDF: En

The nuclear reaction rate formula used in stellar evolution calculation is carefully examined. A uniform expansion is performed up to fourth order in the relevant physical parameter. The convergence of the series is assessed and a semianalytical expression is derived, valid for all values of the expansion parameter. The formulae with electron screening and plasma dissipative collision effects are also evaluated. The agreement of the approximate analytical formulae with the exact result is excellent over a wide range of values of the parameters

1835 downloads

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