Abstract To investigate the effect of pre-injection Shenfu injection on the hemodynamics of radical resection of colorectal cancer in elderly patients with hypertension. The candidates were randomly divided into control group (receiving pre-injection of sodium chloride injection) and research group (receiveing pre-injection of Shenfu injection) before anesthesia induction. The perioperative hemodynamic changes and use of vasoactive drugs were compared. Mean arterial pressure (MAP), diastolic blood pressure (DBP) and systolic blood pressure (SBP) values in the research group were lower than those in the control group at the time of tracheal tube extraction (P < 0.05). The use rate of antihypertensive drugs in the research group was lower than those in the control group (P < 0.05). Pre-injection of Shenfu in elderly hypertensive patients had no influence on anesthesia effect and it can reduce the volatility of hemodynamic parameters, decrease the use of vasoactive drugs.

Abstract We aim to investigate the effect of Shenfu injection before anesthesia on shivering and its impact on hemodynamic parameters. Eighty patients underwent transurethral resection of the prostate were randomized and received 50 mL Shenfu injection (experiment group) or 50 mL 0.9% sodium chloride injection (control group) before anesthesia. Incidence of shivering, axillary temperature, heart rate, systolic and diastolic blood pressure were monitored before, during, and after surgery. Compared to the control group, patients in the experiment group had significantly less decrease in temperature (36.02 ± 0.29 °C in the experiment group versus 35.50 ± 0.33 °C in the control group, p = 0.047). Patients in the experiment group had lower incidence of shivering (10% in the experiment group versus 27.5% in the control group, p = 0.042). On average, patients in the experiment group had significantly more stable hemodynamic parameters: with lower heart rate, less decrease in systolic and diastolic blood pressure (p < 0.05 for all). No significant difference in adverse events were observed. Our study demonstrated that among elderly patients who received transurethral resection of prostate under combined spinal and epidural anesthesia, Shenfu injection before anesthesia prevented postoperative shivering and reduced the temperature and hemodynamic perturbation of anesthesia and surgery.