Abstract Background The coexistence of amyotrophic lateral sclerosis (ALS) with clinical forms of Parkinson disease (PD), although uncommon, is found to a greater degree than one would expect by chance. The pathological mechanisms of ALS and PD are still not fully understood, and the coexistence of these two diseases suggests that they could share mechanisms in common. Objective Here we present a sample of patients with clinically definitive or probable ALS who were evaluated with single-photon emission computed tomography SPECT/TRODAT and compared with non-ALS controls. Methods Patients with clinically definite or probable ALS were assessed with the amyotrophic lateral sclerosis functional rating scale (ALSFRS) to define severity and had their demographic data collected. The TRODAT results of patients with ALS were compared with those of patients with a diagnosis of PD with less than 10 years of duration, and with patients with a diagnosis of others movement disorders not associated with neurodegenerative diseases. Results A total of 75% of patients with ALS had TRODAT results below the levels considered normal; that was also true for 25% of the patients in the control group without neurodegenerative disease, and for 100% of the patients in the PD group. A statistically significant difference was found between patients with ALS and the control group without neurodegenerative disease in the TRODAT values < 0.05. Conclusions Our study fits with the neuropathological and functional evidence that demonstrates the existence of nigrostriatal dysfunction in patients with ALS. Further research to better understand the role of these changes in the pathophysiological process of ALS needs to be performed.

Resumo Antecedentes A coexistência da esclerose lateral amiotrófica (ELA) com formas clínicas da doença de Parkinson (DP), embora incomum, é encontrada em um grau maior do que seria esperado ao acaso. Os mecanismos patológicos da ELA e da DP ainda não são totalmente compreendidos e a coexistência dessas duas doenças sugere que elas podem compartilhar mecanismos em comum. Objetivo Apresentamos uma amostra de pacientes com ELA clinicamente definida ou provável que foram avaliados com tomografia computadorizada por emissão de fóton único (SPECT)/TRODAT e comparados com controles sem ELA. Métodos Pacientes com ELA clinicamente definida ou provável foram avaliados com a escala funcional de esclerose lateral amiotrófica (ALSFRS) para definir a gravidade e foram coletados os seus dados demográficos. Os resultados do TRODAT de pacientes com ELA foram comparados com aqueles de pacientes com diagnóstico de DP com menos de 10 anos de duração e com pacientes com diagnóstico de outros distúrbios do movimento não associados a doenças neurodegenerativas. Resultados Um total de 75% dos pacientes com ELA apresentou resultados de TRODAT abaixo dos níveis considerados normais; 25% no grupo controle sem doença neurodegenerativa e 100% no grupo DP. Uma diferença estatisticamente significativa foi encontrada entre os pacientes com ELA e o grupo controle sem doença neurodegenerativa nos valores de TRODAT p< 0,05. Conclusões Nosso estudo está de acordo com as evidências neuropatológicas e funcionais que demonstram a existência de disfunção nigroestriatal em pacientes com ELA. Mais pesquisas para entender melhor o papel dessas mudanças no processo fisiopatológico da ELA precisam ser realizadas.

The demographic and nutritional transition in Chile has been reflected by a high and growing prevalence of obesity and chronic illnesses related to nutrition. In spite of the efforts made, it is not likely that the country will comply with the health objectives proposals for 2010 to reduce obesity and sedentary tendencies. As part of their functions the National Health Food and Nutrition Advisory Council has recently checked and defined the national priorities in this area. In the Council's opinion, the efforts should be oriented to strengthen the nutritional intervention strategy through the vital cycle, to improve the institutional capacity of the country as far as food is concerned, to review and modernized feeding programmes and to develop a strategic alliance with food producing companies, scientific societies, academic groups and consumers. These actions are directed to promote a wider and better offer of healthier food and to regulate publicity. In order to advance in these proposals we need a major investment from public and private resources oriented to promote healthier styles of living, with special emphasis on nutrition and physical activity

La transición demográfica y nutricional que vive Chile se ha reflejado en una prevalencia alta y creciente de obesidad y enfermedades crónicas vinculadas a la alimentación. A pesar de los esfuerzos realizados es poco probable cumplir con las metas sanitarias propuestas para el 2010 en cuanto a reducir la obesidad y el sedentarismo. Como parte de sus funciones el Consejo Asesor en Nutrición y Alimentación del Ministerio de Salud ha revisado recientemente y definido las prioridades nacionales en este campo. En la opinión del Consejo los esfuerzos debieran orientarse fundamentalmente a fortalecer la estrategia de intervención nutricional a través del ciclo vital, a mejorar la capacidad institucional del país en el ámbito de los alimentos, a revisar y modernizar la gestión de los programas alimentarios y a desarrollar una alianza estratégica con las empresas productoras de alimentos, sociedades científicas, grupos académicos y con los propios consumidores orientada a promover una mayor oferta y consumo de alimentos saludables y a regular la publicidad en este campo. Para avanzar en la meta propuesta se requiere sin duda de una mayor inversión de recursos públicos y privados fundamentalmente orientados a la promoción de estilos de vida saludable, con especial énfasis en alimentación y actividad física