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Abstract In Malignant Hilar Biliary Stricture (MHBS) palliative biliary drainage is a frequent strategy, improving the quality of life, reducing pruritus, loss of appetite and relieving cholangitis. The endoscopic approach is an effective, although challenging procedure. This study aimed to evaluate technical and clinical success rates of biliary drainage by ERCP. This is a retrospective study including all patients with MHBS referred to Instituto do Cancer do Hospital de São Paulo (ICESP) submitted to biliary drainage by ERCP, between January 2010 and December 2017. Multivariable logistic regression was performed to evaluate predictors of clinical failure, as total bilirubin levels, Bismuth classification, number of hepatic sectors drained and presence of cholangitis. In total, 82 patients presenting unresectable MHBS were included in this study. 58.5% female and 41.5% male, with a mean age of 60±13 years. Bismuth classification grades II, IIIA, IIIB and IV were noted in 23.2%, 15.9%, 14.6% and 46.3%, respectively. Technical and clinical success was achieved in 92.7% and 53.7% respectively. At multivariable logistic-regression analyses, Bismuth IV strictures were related to higher clinical failure rates when compared to other strictures levels, with an Odds Ratio of 5.8 (95% CI 1.28‒20.88). In conclusion, endoscopic biliary drainage for malignant hilar biliary stricture had a high technical success but suboptimal clinical success rate. Proximal strictures (Bismuth IV) were associated with poor drainage outcomes.

https://doi.org/10.1016/j.clinsp.2022.100153

Deep sea ecosystem exploration and ‘health check’: sampling strategy and methods applied during the iAtlantic_BR10_Petrobras cruise in the Santos Basin, Southwest Atlantic
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Perez, Jose Angel A.

; Barros Neto, Halésio M.C. de

; Arantes, Renata C.M.

; Gaurisas, Daniela Y.

; Silva, Camila F.

; Alves, Fernanda Maria M.

; Costa, Júlia A.

; Eloi, Paula D.C.

; Fonseca, Thayse S.

; Gavazzoni, Lucas

; Lonskis, Isabella da S.

; Nardi, Ricardo U.

; Nascimento, Pedro O.

; Rodrigues, João Vitor M.

; Santos, Ana Lara F. dos

; Santos, Edson C. dos

; Schroeder, Rafael

; Silva, Luis Carlos da

; Souza, Fernanda dos S.S. de

; Bernardino, Ângelo F.

; Cavalcanti, Guarani H.

; Lindner, Alberto

; Mahiques, Michel M. de

; Millo, Christian

; Reis, Priscila

; Sweetman, Andrew K.

; Roberts, J. Murray

Ocean and Coastal Research

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2023, Volume 71 elocation e23046

Abstract: En | Text: En | PDF: En

Abstract The iAtlantic Project has established an international collaborative strategy to improve mapping and characterization of deep and open ocean ecosystems in understudied regions of the Atlantic and evaluate their health. In December 2022, the first iAtlantic expedition in the South Atlantic set off to map and explore seafloor ecosystems in the Santos Basin slope (200-1,000 m depths) in collaboration with the Petrobras ‘Santos Basin - Regional Characterization Project.’ The 17-day ‘iAtlantic_BR10-Petrobras’ cruise was conducted on board the research vessel NPqHOc Vital de Oliveira (Brazilian Navy) and performed (a) water column structure characterization, (b) seafloor morphology mapping, (c) description of benthic habitats and communities by seafloor imagery and biological/ geological sampling, and (d) ex-situ experiments to assess the functioning of sedimentary ecosystems and their responses to climate-related environmental changes. This study describes the rationale behind the iAtlantic_BR10-Petrobras cruise science plan, reports its sampling strategy and methods, and summarizes its collected data and preliminary results.

https://doi.org/10.1590/2675-2824071.23069jaap

Comparison of Pre- and Posttreatment Airway Volume in Patients with Temporomandibular Joint Disorders Treated with Ultra-Low Frequency Transcutaneous Electrical Nerve Stimulation Using Cone Beam Computed Tomography
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Verghese, Rhea Susan

; Jose, Renju

; Ramachandran, Anu

; Shanmugham, Aravind M.

; Nair, Priya K.

; Kumar, Krishna S.

; Varma, Beena R.

International Archives of Otorhinolaryngology

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2023, Volume 27 N. 4 Pages 593 - 601

Abstract: En | Text: En | PDF: En

Abstract Introduction Temporomandibular joint disorders (TMD) present with a multitude of symptoms that can range from headaches to shoulder pain. Patients frequently present with pain in the ear, dizziness, and vertigo. It is noted that some patients who report TMDs also have a history of sleep disturbances, which is noted in cone beam computed tomography (CBCT) as a reduction in the oropharyngeal airway volume. Objective To evaluate the airway volume in pre- and posttreatment of TMD with the use of neuromuscular orthotics made with ultra-low frequency transcutaneous electrical nerve stimulation (ULF-TENS). Methods A total of 15 patients were evaluated for TMDs using the related criteria. Those included were treated with ULF-TENS with evaluation of the airway volume both pre- and posttreatment using CBCT and the Dolphin 3D volume analysis software. Results While the symptoms were shown to be significantly reduced in patients who were treated with this particular modality, the airway volume varied in those who reported a reduction after a period of 3 months and those that reported after a period of 6 months. Conclusion Posttreatment evaluation of the airway should be done after a period of 6 months for a more objective evaluation. A multidisciplinary evaluation of the patient is required in such cases.

https://doi.org/10.1055/s-0042-1758207

Insecticidal effect of hydroalcoholic extracts of Pleurotus ostreatus against Sitophilus zeamais
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Palavecino-De-La-Fuente, Fernanda

; Silva-Aguayo, Gonzalo

; Figueroa-Cares, Inés

; Gerding, Macarena

; Rodríguez-Maciel, Jose Concepción

; Lagunes-Tejeda, Angel

; Castañeda-Ramirez, Gloria Sarahi

; Sotelo-Leyva, César

; Curkovic, Tomislav

; Aguilar-Marcelino, Liliana

Chilean journal of agricultural research

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sep 2022, Volume 82 N. 3 Pages 399 - 406

Abstract: En | Text: En | PDF: En

ABSTRACT The maize weevil (Sitophilus zeamais Motschulsky, 1855; Coleoptera, Curculionidae) is one of the most important pests associated with stored grains. It is controlled almost exclusively with synthetic insecticides. Thus, leading to problems such as pollution and resistance development. Hence an alternative is the use of natural compounds such as edible mushrooms derivates. The aim of this research was to assess, under laboratory conditions, the insecticidal and insectistatic effect of a hydroalcoholic extract of Pleurotus ostreatus (Jacq.) P. Kumm. 1871 against adults of S. zeamais. The parameters assessed were contact and fumigant toxicity, repellency, and antifeedant effect. The highest contact toxicity (57.5% mortality) was achieved with 30 mL extract L-1 solvent. No treatment showed repellent effect; the repellency index (RI) values were higher than 1, and the antifeeding activity < 30%. The fumigant effect showed a maximum of 30% mortality with the highest concentration (300 μL L-1 air). The hydroalcoholic extract of P. ostreatus exerts contact toxicity and interferes with insect reproduction or oviposition of Sitophilus zeamais.

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The Medical Burden of Heart Failure: A Comparative Delineation with Cancer in Brazil
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Almeida, Dirceu Rodrigues de

; Pereira-Barretto, Antonio Carlos

; Forestiero, Francisco Jose

; Nakamuta, Juliana S.

; Bichels, André

International Journal of Cardiovascular Sciences

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aug 2022, Volume 35 N. 4 Pages 514 - 520

Abstract: En | Text: En | PDF: En

Abstract Background: Due to its poor prognosis and mortality rates, heart failure (HF) has been recognized as a malignant condition, comparable to some cancers in developed countries. Objectives: To compare mortality from HF and prevalent cancers using data from a nationwide database in Brazil. Methods: This was a descriptive, cross-sectional study using secondary data obtained from Brazilian administrative databases of death records and hospitalization claims maintained by the Ministry of Health. Data were analyzed according to main diagnosis, year of occurrence (2005-2015), sex and age group. Descriptive analyses of absolute number of events, hospitalization rate, mortality rate, and in-hospital mortality rate were performed. Results: The selected cancers accounted for higher mortality, lower hospitalization and higher in-hospital mortality rates than HF. In a group analysis, HF showed mortality rates of 100-150 per 100,000 inhabitants over the period, lower than the selected cancers. However, HF had a higher mortality rate than each type of cancer, even when compared to the most prevalent and deadly ones. Regarding hospitalization rates, HF was associated with a higher risk of hospitalization when compared to cancer-related conditions as a group. Conclusions: Our findings indicate that HF has an important impact on mortality, hospitalization and in-hospital mortality, comparable to or even worse than some types of cancer, representing a potential burden to the healthcare system.

https://doi.org/10.36660/ijcs.20200382

Reaction of wild solanaceae species to Meloidogyne incognita
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Silva, Eveline Mendes da

; Rocha, Fernando da Silva

; Barbosa, Edimilson Alves

; Oliveira, João Alison Alves

; Neves, Jose Maria Gomes

; Barbosa, Dandara Maria Clara do Rosário

; Muniz, Maria de Fátima Silva

Revista Ceres

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may 2022, Volume 69 N. 3 Pages 368 - 373

Abstract: En | Text: En | PDF: En

ABSTRACT The quest for resistance sources against Meloidogyne incognita as a control measure is essential in tomato. Thus, this study aimed to evaluate the reaction of six species of wild solanaceae to M. incognita. The species of wild solanaceae studied were Solanum capsicoides, S. asperolanatum, S. americanum, S. viarum, S. palinacanthum and Nicandra physaloides. Seedlings of wild solanaceae species were transplanted and inoculated with M. incognita. The experiment was performed in a completely randomized design with eight replicates. The analyzed variables were: height of the aerial portion, fresh weight of the aerial portion, fresh weight and length of the root system, gall index, number of galls/g of root, number of egg masses/g of root, number of eggs/g of root and the nematode reproduction factor. Based on gall index and reproduction factor criteria the species S. capsicoides, S. americanum, S. palinacanthum and N. physaloides were classified as resistant against M. incognita. These species also showed a significant increase in height and fresh weight of the aerial portion, length of the root system and fresh weight of the root system. Therefore, these species of wild solanaceae may contribute to the management of M. incognita in future applications.

https://doi.org/10.1590/0034-737x202269030015

Vascular retinal findings after COVID-19 vaccination in 11 cases: a coincidence or consequence?
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Silva, Letícia S. C. da

; Finamor, Luciana P. S.

; Andrade, Gabriel C.

; Lima, Luiz H.

; Zett, Claudio

; Muccioli, Cristina

; Sarraf, Eduardo P.

; Marinho, Paula M.

; Peruchi, Julia

; Oliveira, Raiza D. de L.

; Giralt, Lena

; Charcan, Ivonne

; Fonollosa, Alex

; Diaz, Jose D.

; Davis, Janet L.

; Nascimento, Heloisa

; Belfort Jr, Rubens

Arquivos Brasileiros de Oftalmologia

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apr 2022, Volume 85 N. 2 Pages 158 - 165

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivos: o principal objetivo deste estudo foi descrever pacientes com achados vasculares retinianos temporalmente relacionados à vacinação contra COVID-19. Com maior notificação de possíveis eventos adversos similares, esperamos compreender a real dimensão e relevância do que foi apresentado. Métodos: Onze pacientes com queixas visuais após vacinação contra COVID-19 foram estudados. Os dados analisados foram: idade, gênero, tipo de vacinação, tempo de aparecimento de sintomas, achados sistêmicos, antecedentes pessoais, acuidade visual com melhor correção, biomicroscopia e imagem retiniana multimodal (retinografia colorida, red-free, SD-OCT, OCTA e angiofluoresceinografia). Os critérios de inclusão foram a presença de alterações oftalmológicas ocorridas dentro de 30 dias após a primeira ou segunda dose de qualquer vacina contra COVID-19. Resultados: Onze pacientes foram incluídos: 5 com oclusão arterial (45,4%), 4 com oclusão venosa (36,4%) e 2 (18,2%) com alterações não específicas vasculares sugestivas de isquemia retiniana como exsudatos algodonosos. A idade média dos pacientes foi de 57 anos (DP=16; com intervalo de 27 a 84 anos). A média de tempo de aparecimento de sintomas após a vacinação foi de 10 dias (DP=5,4; com intervalo de 3 a 16 dias). Nove dos onze pacientes eram do sexo feminino (81,8%). Fatores de risco sistêmicos foram observados em 36,4% dos pacientes. Dois pacientes tiveram sintomas neurológicos e visuais, com oclusão arterial. 36,4% dos pacientes tiveram infecção prévia por COVID-19 no último ano. Sete pacientes (63,6%) receberam a vacina ChAdOx1 nCoV-19 (AZD1222). Conclusões: nossos dados sugerem que eventos retinianos temporalmente relacionados à vacinação contra COVID-19 são possíveis, porém raros. A relação entre estes eventos pós-vacinais exigem futura atenção antes de maiores conclusões.

ABSTRACT Purpose: The primary purpose of this study was to assess vascular retinal findings temporally related to COVID-19 vaccination. With greater information regarding all possible future adverse events, we hope to understand the real dimension and relevance of what was presented. Methods: Eleven patients with visual complaints after COVID-19 vaccination were enrolled. Data on the following were included: age, sex, vaccine, time of symptom onset, systemic findings, medical history, best-corrected visual acuity, and ocular findings by slit-lamp biomicroscopy as well as multimodal retinal imaging (color fundus, red-free photography, spectral-domain optical coherence tomography, optical coherence tomography angiography, and fluorescein-angiography). Inclusion criteria were the presence of ophthalmologic signs within 30 days after the first or second dose of any COVID-19 vaccine. Results: Of 11 patients, five had arterial occlusion (45.4%), four had venous occlusion (36.4%), and two (18.2%) had nonspecific vascular alterations suggestive of retinal ischemia such as cotton-wool spots. The mean age was 57 (SD = 16; range: 27-84) years. The mean time of symptoms onset was 10 (SD = 5.4; range: 3-16) days. Nine patients were female (81.8%). Systemic risk factors were observed in 36.4% of patients. Two patients had both neurological and visual symptoms, with arterial occlusion. Overall, 36.4% patients had COVID-19 in the previous year. Seven patients (63.6%) received ChAdOx1 nCoV-19 (AZD1222) vaccine. Conclusions: Our data suggest that retinal events temporally related to COVID-19 vaccination are possible but are very rare. The relationship of these events with post-COVID-19 vaccination warrants further attention to derive a meaningful conclusion.

https://doi.org/10.5935/0004-2749.20220071

Infective endocarditis: 10-year experience in a non-cardiovascular center
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Ruiz-Beltran, Arturo M.

; Barron-Magdaleno, Clemente

; Ruiz-Beltran, Sandra M.

; Sánchez-Villa, Jose D.

; Orihuela-Sandoval, Consuelo

; Oseguera-Moguel, Jorge

; Payro-Ramírez, Gerardo

Archivos de cardiología de México

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mar 2022, Volume 92 N. 1 Pages 5 - 10

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract Background and objective: Infective endocarditis (IE) is an infection with a poor prognosis, and an associated in-hospital mortality of at least 25%. Optimal therapy of IE requires long-term effective antibiotic therapy and valve surgery in many cases. The aim of this study was to review the demographics, bacteriology, and outcomes of patients with IE admitted to a tertiary referral center in Mexico City, over a 10-year period. Methods: Retrospective cohort study of patients admitted at Instituto Nacional Salvador Zubiran with a new diagnosis of IE over a 10-year period, from January 2009 to January 2019. Patients who met the definition for definitive diagnosis of infective endocarditis according to the modified Duke criteria were included in the study. Results: There were 62 patients (50.85 ± 17.46 years, 40.3% females) with IE. The culprit microorganism was identified in all cases, with Staphylococcus aureus being the most frequently found (34%). Valve surgery was performed in 58.1%, while 41.9% only received medical treatment. The mortality rate was 25.8% at 30 days and 41.9% at 12 months. Comparing the surgical and medical treatment groups, we found that 50% and 36% in each group, respectively, had died within 12 months of admission. Conclusions: Our center has a high prevalence of health care-associated endocarditis, mostly related to the presence of intravascular access devices. Most of the patients had a surgical indication. Patients with type 2 diabetes mellitus and decreased right ventricular systolic function had an increased mortality rate at 12 months.

Resumen Antecedentes y objetivo: La endocarditis infecciosa (EI) es una infección de mal pronóstico, con una mortalidad intrahospitalaria que va del 15-20%. La terapia óptima requiere antibioticoterapia efectiva por tiempo prolongado y cirugía valvular en algunos casos. El objetivo de este estudio fue revisar la epidemiología y desenlaces de pacientes con EI en un centro de referencia en la Ciudad de México. Métodos: Cohorte retrospectiva de pacientes admitidos al Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán con diagnóstico de EI en un periodo de 10 años, de enero de 2009 a enero de 2019. Se incluyeron a pacientes que cumplían la definición de diagnóstico definitivo de endocarditis infecciosa de acuerdo a los criterios modificados de Duke. Resultados: Se incluyeron a 62 pacientes (50.85 ± 17.46 años, 40.3% mujeres). Todos los casos tuvieron cultivos positivos, siendo S. aureus el microorganismo más frecuente (34%). El 58.1% de los pacientes recibió tratamiento quirúrgico y 41.9% recibió únicamente tratamiento médico. La mortalidad a 30 días fue de 25.8% y a 12 meses fue de 41.9%. Comparando los grupos de tratamiento médico y quirúrgico, se encontró que 50% y 36% de cada grupo, respectivamente, habían fallecido a los 12 meses. Conclusiones: Encontramos una alta prevalencia de EI asociada a los cuidados de la salud, principalmente en relación a accesos intravasculares. Casi todos los pacientes presentaban un criterio quirúrgico al momento del diagnóstico. Los pacientes con diabetes mellitus tipo 2 y función sistólica del ventrículo derecho disminuida presentaron una mayor mortalidad a 12 meses.

https://doi.org/10.24875/acm.20000467 108 downloads

Cushing’s syndrome due to ectopic adrenocorticotropin secretion by a parotid carcinoma
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Antonacio, Fernanda F.

; Harada, Guilherme

; Vilela, Rafael S.

; Freitas, Thais C.

; Lima Jr., Jose V.

; Kowalski, Luiz Paulo

; Almeida, Madson Q.

; Castro Junior, Gilberto de

Archives of Endocrinology and Metabolism

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feb 2022, Volume 66 N. 1 Pages 92 - 96

Abstract: En | Text: En | PDF: En

SUMMARY We report a rare case of Cushing’s syndrome in a 37-year-old female who initially presented with localized acinic cell carcinoma of the parotid gland. In January 2014, she underwent a right parotidectomy with facial nerve preservation and adjuvant radiotherapy. In August 2018, she presented a histologically-proven local regional relapse. The patient was considered for salvage surgery with facial nerve sacrifice and remained with no evidence of disease. One year later the patient developed pulmonary dissemination and started to gain weight and developed facial plethora and acne on the face and upper trunk. In a physical examination, the patient presented moon face, buffalo hump, acne and stage 2 hypertension. Biochemical evaluation confirmed ACTH-dependent Cushing’s syndrome. IHC for ACTH in the lung biopsy revealed strong positive staining for ACTH confirming a diagnosis of ectopic ACTH secretion by a metastatic parotid acinic cell carcinoma. Ketoconazole (600 mg/d) was started to treat the CS. In addition, as chemotherapy was initiated to treat the metastatic disease. After the fifth cycle of chemotherapy, ketoconazole was suspended and the patient remained in remission of CS for four months, when CS recurred. A unique feature of this case is related to the clinical CS relapse associated with disease progression, which needed prompt treatment with ketoconazole, resulting in a significant improvement in the patient’s condition. Although rare, should be attentive for possible CS features in patients with high-grade salivary gland carcinomas, since the diagnosis of ectopic secretion of ACTH may significantly impact their management and outcomes.

https://doi.org/10.20945/2359-3997000000426

10.

Implementation of a Lean Manufacturing and SLP- based system for a footwear company
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Silvestre, Sergio Enrique Munive

; Chaicha, Victor David Paucar

; Merino, Jose Carlos Alvarez

; Nallusamy, S.

Production

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2022, Volume 32 elocation e20210072

Abstract: En | Text: En | PDF: En

Abstract Paper aims This research article addresses an innovative solution to face one of the main problems in the footwear industry, namely the high order non-fulfillment rate. Originality This research offers companies in the footwear industry the possibility of implementing Andon through a structured and planned process that allows expediting problem solving. The advantage of this system is the ability to signal the status of workstations through rapid visual identification. Moreover, in this way social distancing is also secured, in line with World Health Organization guidelines to prevent the spread of COVID-19. Research method The article presents four phases through which the case study was addressed. Planning (determination of objectives), Restructuring of the Operations Area, Improvement of the Production Line and Continuous Improvement. Main findings An Arena simulation system was used to establish a new scenario where the defective product indicator decreases by 3.13% and productivity improves by about 38%. In turn, the resulting increase in the number of orders enhances company sales and profits, as well as the ability to meet the customer demand in a timely manner. Implications for theory and practice The case study suggests that the main causes of this issue (high order non-fulfillment rate) are the increasing rate of defective goods, delays in the production process, and excessive time consumption in the movement of staff and materials. This research serves as the basis for future lines of research, as well as for other organizations with similar characteristics to implement the proposal.

https://doi.org/10.1590/0103-6513.20210072

11.

Technological Perspectives and Economic Aspects of Green Hydrogen in the Energetic Transition: Challenges for Chemistry
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Guarieiro, Lilian L. N.

; Anjos, Jeancarlo P. dos

; Silva, Luciana A. da

; Santos, Alex Á. B.

; Calixto, Ewerton E. S.

; Pessoa, Fernando L. P.

; Almeida, Jose L. G. de

; Andrade Filho, Miguel

; Marinho, Flavio S.

; Rocha, Gisele O. da

; Andrade, Jailson B. de

Journal of the Brazilian Chemical Society

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2022, Volume 33 N. 8 Pages 844 - 869

Abstract: En | Text: En | PDF: En

Green hydrogen is a fuel capable of promoting sustainable energy development and is gaining attention in the current global energy transition framework. The global shift toward decarbonization has triggered a substantial boost in the hydrogen industry. This study presents an overview of the current status of hydrogen production, regulation of the green hydrogen segment, hydrogen storage, distribution, and transportation, and final use and application. We also critically discuss the viability of adopting green hydrogen in terms of possible economic and environmental impacts as well as the main challenges and opportunities it represents for the Chemical Sciences.

https://doi.org/10.21577/0103-5053.20220052

12.

Progressive improvement of atrial and ventricular capture thresholds, sensing, and impedances in epicardial pacing leads in young adults undergoing Fontan conversion
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Moltedo, Jose M.

; Abello, Mauricio S.

; Doiny, David

; Falconi, Estela C.

; Diaz, Carlos J

; Majdalani, María G.

; Cannon, Bryan C.

Archivos de cardiología de México

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dec 2021, Volume 91 N. 4 Pages 439 - 443

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract Objectives: Patients with univentricular hearts who require permanent pacing systems typically require placement of epicardial leads. It is frequently difficult to find a position with good thresholds due to epimyocardial fibrosis or fat. The goal of the study is to assess the progression of capture thresholds (CT), sensing parameters (P waves and R waves), and impedances (imp) of steroid eluting epicardial pacing leads in young adults who underwent Fontan conversion and a pacemaker implant. Methods: All patients undergoing Fontan conversion in two institutions were retrospectively identified. Demographic data, congenital heart defects, pacing leads used, and pacing parameters were analyzed at implant, at 6 weeks and 12 months after implant. Results: Twenty patients were identified (twelve males); mean age at conversion was 24.9 ± 5.4 years (range 18-35). Epicardial bipolar steroid eluting leads were used. The site of implant both in the atria and the ventricles varied depending on the parameters. At implant, mean atrial and ventricular impedances were 617 ± 171 W and 1061 ± 771 W, respectively, mean P wave amplitude was 2 ± 0.7 mV, and mean R wave amplitude was 12.5 ± 7.7 mV. Mean CT was 1.7 ± 0.8 V at 0.5 ms for the atrium and 2.2 ± 1.2 V at 0.5 ms for the ventricle. Ventricular CT and impedance showed an improvement within the first 12 months after implant, with four patients having a decrease in threshold of more than 2 V. Conclusion: In patients undergoing Fontan conversion, implant ventricular CT and impedances are frequently higher than expected but typically improve during follow-up. Acceptance of higher initial threshold values may be a potential strategy in this patient population.

Resumen Objetivos: Los pacientes con corazón univentricular que requieren estimulación cardíaca reciben sistemas de estimulación epicárdicos. Debido a la presencia de fibrosis o grasa epi-miocárdica es dificultoso en esta población encontrar sitios con adecuados parámetros de estimulación. El objetivo de este estudio es determinar la progresión de los umbrales de captura, los parámetros de sensado (medición de las ondas P y R) e impedancias (imp) de los catéteres epicárdicos con liberación de esteroides implantados en adultos jóvenes sometidos a cirugía de reconversión de Fontan e implante de marcapasos. Métodos: Los pacientes sometidos a cirugía de reconversión de Fontan en dos instituciones fueron analizados retrospectivamente. Los datos demográficos, el tipo de cardiopatía congénita, de catéteres de estimulación y los parámetros de estimulación fueron analizados al momento del implante, a las 6 semanas y al año. Resultados: Se identificaron 20 pacientes (12 de ellos de sexo masculino); la edad media al momento de la reconversión fue de 24.9 ± 5.4 años (rango 18-35). Se utilizaron catéteres epicárdicos bipolares de fijación pasiva y con liberación de esteroides en todos los casos. El sitio de implante en las aurículas y en los ventrículos fue variable de acuerdo a los parámetros. En el momento del implante las impedancias medias fueron 617 ± 171 W y 1061 ± 771 W respectivamente, la amplitud media de la onda P fue 2 ± 0.7 mV y la media de amplitud de la onda R fue de 12.5 ± 7.7 mV. Las medias de los umbrales de captura fueron 1.7 ± 0.8 V at 0.5 ms para los catéteres auriculares y 2.2 ± 1.2 V at 0.5 ms para los ventriculares. Los umbrales de captura y las impedancias ventriculares mostraron una mejoría en los 12 meses posteriores al implante, y en 4 pacientes esa mejoría en el umbral de captura ventricular fue mayor a 2 V. Conclusiones: En pacientes sometidos a una cirugía de reconversión de Fontan e implante de marcapasos, los umbrales de captura e impedancias ventriculares son más elevados que los esperados, pero mejoran durante el seguimiento. La aceptación de valores más elevados puede potencialmente constituir una alternativa en esta población de pacientes.

https://doi.org/10.24875/acm.20000426 10 downloads

13.

Efecto de Saccharomyces cerevisiae y tiempos de fermentación sobre la composición química del ensilado de avena y cebada
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Fernandez Taype, Ricardo

; Contreras Paco, Jose Luis

; Curasma Ccente, James

; Cordero Fernández, Alfonso

; Rojas De La Cruz, Yhan Carlos

; Ruiz Vilchez, David

; Huaman Jurado, Rodrigo

Revista de Investigaciones Veterinarias del Perú

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nov 2021, Volume 32 N. 6 elocation e21681

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

RESUMEN El objetivo del estudio fue evaluar los efectos de la levadura Saccharomyces cerevisiae como aditivo para la preparación de ensilado de avena y cebada en dos tiempos de fermentación (21 y 42 días). Se prepararon minisilos de avena y cebada y se evaluaron cuatro niveles de levadura (0, 15, 30 y 45 g/kg FV). Los minisilos fueron abiertos a los 21 y 42 días. Se prepararon tres repeticiones de ensilado para cada combinación de ensilado x nivel de levadura x tiempo de ensilado. Los valores de composición bromatológica del ensilado de avena en términos de proteína cruda (PC), materia mineral (MM), fibra detergente neutra (FDN), fibra detergente ácida (FDA), extracto etéreo (EE) y pH aumentaron cuando se agregó la levadura con relación al control, pero disminuyó la materia seca (MS). La calidad del ensilado de cebada en términos de MS, PC, FDN, FDA y EE mejoró al agregar 30 y 45 g/kg de levadura, en comparación al control; sin embargo, disminuyó para EE y pH. Los resultados demuestran que la inoculación de S. cerevisiae en los dos tiempos de fermentación incrementa el contenido de PC, EE, MM y pH del ensilado; sin embargo; el alto nivel de pH no permite conservar la calidad del ensilado. Se concluye que el mejor valor nutricional se obtuvo con la adición de S. cerevisiae de 45 g/ kg a los 42 días de fermentación en ambos ensilados, aunque disminuye algunos parámetros de importancia.

ABSTRACT The aim of this study was to evaluate the effects of the yeast Saccharomyces cerevisiae as an additive for the preparation of oat and barley silage in two fermentation times (21 and 42 days). Oat and barley minisilos were prepared using four levels of yeast (0, 15, 30 and 45 g/kg FV). The minisilos were opened at 21 and 42 days. Three silage replicates were prepared for each combination of silage x yeast level x silage time. The bromatological composition values of the oat silage in terms of crude protein (CP), mineral matter (MM), neutral detergent fibre (NDF), acid detergent fibre (FDA), ethereal extract (EE) and pH increased when the yeast was added in relation to the control, but the dry matter (DM) decreased. The quality of the barley silage in terms of DM, CP, NDF, FDAand EE improved when adding 30 and 45 g/kg of yeast, compared to the control; however, it decreased for EE and pH. The results show that the inoculation of S. cerevisiae in the two fermentation times increases the content of CP, EE, MM and pH of the silage; nevertheless; the high pH level does not allow proper conservation of the quality of the silage. It is concluded that the best nutritional values were obtained with the addition of S. cerevisiae of 45 g/kg at 42 days of fermentation in both silages, although it decreases some important parameters.

https://doi.org/10.15381/rivep.v32i6.21681

14.

Preparation, Spectral Characterization and Anticancer Potential of Cinnamic Esters
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Gonçalves, Renan O.

; Farias,, Iolanda F. de

; Silva,, Maria Francilene S.

; Pessoa, Cláudia Ó.

; Zocolo, Guilherme J.

; Zampieri, Davila

; Lemos, Telma Leda G. de

; Monte, Francisco Jose Q.

Journal of the Brazilian Chemical Society

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oct 2021, Volume 32 N. 10 Pages 1931 - 1942

Abstract: En | Text: En | PDF: En

Cinnamic acid and its derivatives show a remarkable variety of biological activities and are often studied in search of the development of new and highly effective drugs. This work aims to synthesize, characterize and evaluate the cytotoxic activity of esters derived from cinnamic acid. Eighteen esters were synthesized through Steglich’s esterification, of which eleven were not reported in the literature. All compounds were fully characterized by Fourier transform infrared epectroscopy (FTIR), nuclear magnetic resonance (1H and 13C NMR) and high-resolution mass spectrometry (HRMS) data. The cytotoxic activity of esters obtained was evaluated using four human tumor cell lines: SNB-19 (astrocytoma), HCT-116 (colon carcinoma, human), PC3 (prostate) and HL60 (promyelocytic leukemia) through the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium (MTT) colorimetric assay. These studies showed that the compound 3-methoxybenzyl (E)-3-(4-methoxyphenyl)acrylate (12) is the most potent against HCT-116, PC3 and SBN-19 cells, with the lowest half maximal inhibitory concentration (IC50) value of 16.2 µM in the HCT-116 strain. The derivatives were obtained in good yields (76.6-95%), except for compounds 5-isopropyl-2-methylphenyl (E)-3-(3-hydroxy-4-methoxyphenyl)acrylate (17) (18.6%) and 2-isopropyl-5-methylphenyl (E)-3-(3-hydroxy-4-methoxyphenyl)acrylate (18) (15.5%).

https://doi.org/10.21577/0103-5053.20210084 33 downloads

15.

Impact of COVID-19 on education, health and lifestyle behaviour of Brazilian urology residents
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Prezotti, José Antonio

; Henriques, João Victor T.

; Favorito, Luciano A.

; Canalini, Alfredo F.

; Machado, Marcos G.

; Brandão, Thulio B. V.

; Barbosa, Akemi M. V.

; Moromizato, Julyana K. M.

; Anzolch, Karin M. J.

; Fernandes, Roni de C.

; Rodrigues, Fransber R. A.

; Bellucci, Carlos H. S.

; Silva, Caroline S.

; Pompeo, Antonio Carlos L.

; Bessa Jr., Jose de

; Gomes, Cristiano M.

International braz j urol

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aug 2021, Volume 47 N. 4 Pages 753 - 776

Abstract: En | Text: En | PDF: En

ABSTRACT Objectives: To evaluate the impact of COVID-19 on clinical and surgical practice, educational activities, health and lifestyle behavior of Brazilian urology residents. Materials and Methods: A web-based survey was sent to 468 Brazilian urology residents from postgraduate years (PGY) 3 to 5 to collect data on clinical practice and training after 4 months of COVID-19. We also assessed health-related and behavior changes, rate of infection by SARS-CoV-2, deployment to the front line of COVID-19, residents’ concerns, and access to personal protective equipment (PPE). Results: Massive reductions in elective and emergency patient consultations, diagnostic procedures and surgeries were reported across the country, affecting PGY 3 to 5 alike. Most in-person educational activities were abolished. The median damage to the urological training expected for 2020 was 6.0 [3.4 – 7.7], on a scale from 0 to 10, with senior residents estimating a greater damage (P< 0.001). Educational interventions developed included online case-based discussions, subspeciality conferences and lectures, and grand rounds. Most senior residents favored extending residency to compensate for training loss and most younger residents favored no additional training (p< 0.001). Modifications in health and lifestyle included weight gain (43.8%), reduced physical activity (68.6%), increased alcoholic intake (44.9%) and cigarette consumption (53.6%), worsening of sexual life (25.2%) and feelings of sadness or depression (48,2%). Almost half were summoned to work on the COVID-19 front-line and 24.4% had COVID-19. Most residents had inadequate training to deal with COVID-19 patients and most reported a shortage of PPE. Residents’ concerns included the risk of contaminating family members, being away from residency program, developing severe COVID-19 and overloading colleagues. Conclusions: COVID-19 had a massive impact in Brazilian urology residents´ training, health and lifestyle behavior, which may reflect what happened in other medical specialties. Studies should confirm these findings to help developing strategies to mitigate residents’ losses.

https://doi.org/10.1590/s1677-5538.ibju.2021.99.09 170 downloads

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