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A new species of Knodus (Characiformes: Characidae), with deep genetic divergence, from the Mearim and Munim river basins, Northeastern Brazil, and evidence for hidden diversity in adjacent river basins
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Aguiar, Rayane G.

; Guimarães, Erick C.

; Brito, Pâmella S. de

; Santos, Jadson P.

; Katz, Axel M.

; Dias, Luiz Jorge B. da S.

; Carvalho-Costa, Luis Fernando

; Ottoni, Felipe P.

Neotropical Ichthyology

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2022, Volume 20 N. 2 elocation e210173

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Uma nova espécie de Knodus das bacias dos rios Mearim e Munim, Nordeste do Brasil, é descrita com base em taxonomia integrativa, utilizando diferentes métodos moleculares de delimitação de espécies e abordagens independentes. A nova espécie possui a combinação de estados de caráter que geralmente é utilizada para diagnosticar o gênero. A nova espécie possui um padrão de coloração semelhante a K. victoriae, que também é morfologicamente semelhante a ela. A espécie aqui descrita difere de K. victoriae por possuir mais vértebras totais, mais raios ramificados na nadadeira anal e menos escamas circumpedunculares. Nós também fornecemos uma discussão detalhada das características morfológicas diagnósticas exibidas por espécies de Knodus de bacias hidrográficas adjacentes.

Abstract A new species of Knodus from the Mearim and Munim River basins, Northeastern Brazil, is herein described based on integrative taxonomy, by using different molecular based species delimitation methods and independent approaches. The new species possesses the combination of character states that usually diagnoses the genus. The new species possesses a similar colour pattern to K. victoriae, which is also morphologically similar to it. The species described herein differs from K. victoriae by possessing more total vertebrae, more branched anal-fin rays, and fewer circumpeduncular scales. We also provide a detailed discussion of the morphological diagnostic features exhibited by Knodus species from adjacent river basins.

https://doi.org/10.1590/1982-0224-2021-0173

Pegvisomant in acromegaly: a multicenter real-life study in Argentina
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Basavilbaso, Natalia Ximena Garcia

; Ballarino, Maria Carolina

; Bruera, Darío

; Bruno, Oscar D.

; Chervin, Alberto B.

; Danilowicz, Karina

; Fainstein-Day, Patricia

; Fidalgo, Silvina Gabriela

; Frigeri, Adriana

; Glerean, Mariela

; Guelman, Rodolfo

; Isaac, Gabriel

; Katz, Debora Adela

; Knoblovits, Pablo

; Librandi, Fabiana

; Montes, Monica López

; Mallea-Gil, Maria Susana

; Manavela, Marcos

; Mereshian, Paula

; Moncet, Daniel

; Pignatta, Analia

; Rogozinsky, Amelia

; Sago, Laura R.

; Servidio, Marisa

; Spezzi, Monica

; Stalldecker, Graciela

; Tkatch, Julieta

; Vitale, Nicolas Marcelo

; Guitelman, Mirtha

Archives of Endocrinology and Metabolism

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aug 2019, Volume 63 N. 4 Pages 320 - 327

Abstract: En | Text: En | PDF: En

ABSTRACT Objective To describe the long term safety and efficacy of pegvisomant (PEGV), and the predictors of treatment response in patients with acromegaly in the real life setting. Subjects and methods We retrospectively reviewed the clinical, hormonal and radiological data of acromegalic patients treated with PEGV in 17 Argentine centers. Results Seventy-five patients (age range 22-77, 51 females) with acromegaly have been treated with PEGV for up to 118 months (median 27 months). Before PEGV, 97.3% of patients had been treated with medical therapy, surgery and/or radiotherapy, two patients had no previous treatment. At that time, all patients had an IGF-1 above the upper normal limit (ULN) (mean 2.4 x ULN ± 0.98, range 1.25-7). At diagnosis of acromegaly 84% presented macroadenomas, prior to PEGV only 23,5% of patients remained with tumor remnant > 1 cm, the remaining showed normal or less than 1 cm images. Disease control (IGF-1 ≤ 1.2 x ULN) was achieved in 62.9% of patients with a mean dose of 11.8 mg/day. Thirty-four patients (45%) received PEGV monotherapy, while 41 (55%) received combined therapy with either somatostatin analogues and/or cabergoline. Adverse events related to PEGV were: local injection site reaction in 5.3%, elevated liver enzymes in 9.3%, and tumor size growth in 9.8%. Pre-PEGV IGF-I level was the only predictor of treatment response: 2.1 x ULN vs 2.8 x ULN in controlled and uncontrolled patients respectively (p < 0.001). Conclusion this long term experience indicates PEGV treatment was highly effective and safe in our series of Argentine patients with acromegaly refractory to standard therapies. Arch Endocrinol Metab. 2019;63(4):320-7

https://doi.org/10.20945/2359-3997000000160 1306 downloads

Persistent Depressive Symptoms are Independent Predictors of Low-Grade Inflammation Onset Among Healthy Individuals
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Franco, Fábio Gazelato de Mello

; Laurinavicius, Antonio Gabriele

; Lotufo, Paulo A.

; Conceição, Raquel D.

; Morita, Fernando

; Katz, Marcelo

; Wajngarten, Maurício

; Carvalho, José Antonio Maluf

; Bosworth, Hayden B.

; Santos, Raul Dias

Arquivos Brasileiros de Cardiologia

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aug 2017, Volume 109 N. 2 Pages 103 - 109

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Fundamento: Sintomas depressivos estão associados de forma independente ao risco aumentado de doença cardiovascular (DCV) em indivíduos com DCV não diagnosticada. Os mecanismos subjacentes a essa associação, entretanto, não estão claros. Inflamação tem sido indicada como um possível elo mecanicista entre depressão e DCV. Objetivos: Este estudo avaliou a associação entre sintomas depressivos persistentes e o início de inflamação de baixo grau. Métodos: De um banco de dados de 1.508 indivíduos jovens (idade média: 41 anos) sem diagnóstico de DCV submetidos a pelo menos duas avaliações de saúde de rotina, 134 tinham sintomas depressivos persistentes (Inventário de Depressão de Beck - BDI ≥10, BDI+) e 1.374 não apresentavam sintomas em nenhuma das ocasiões (BDI-). Todos os participantes foram submetidos a repetidas avaliações clínicas e laboratoriais em seguimento regular, cuja média foi de 26 meses desde a condição basal. Definiu-se inflamação de baixo grau como concentração plasmática de proteína C reativa (PCR) ultrassensível > 3 mg/L. O desfecho foi a incidência de inflamação de baixo grau por ocasião da segunda avaliação clínica. Resultados: A incidência de inflamação de baixo grau foi maior no grupo BDI+ em comparação ao grupo BDI- (20,9% vs. 11,4%; p = 0,001). Após ajuste para sexo, idade, circunferência abdominal, índice de massa corporal, níveis de atividade física, tabagismo e prevalência de síndrome metabólica, os sintomas depressivos persistentes continuaram sendo um preditor independente de início de inflamação de baixo grau (OR = 1,76; IC 95%: 1,03-3,02; p = 0,04). Conclusões: Sintomas depressivos persistentes foram independentemente associados com início de inflamação de baixo grau em indivíduos saudáveis.

Abstract Background: Depressive symptoms are independently associated with an increased risk of cardiovascular disease (CVD) among individuals with non-diagnosed CVD. The mechanisms underlying this association, however, remain unclear. Inflammation has been indicated as a possible mechanistic link between depression and CVD. Objectives: This study evaluated the association between persistent depressive symptoms and the onset of low-grade inflammation. Methods: From a database of 1,508 young (mean age: 41 years) individuals with no CVD diagnosis who underwent at least two routine health evaluations, 134 had persistent depressive symptoms (Beck Depression Inventory - BDI ≥ 10, BDI+) and 1,374 had negative symptoms at both time points (BDI-). All participants had been submitted to repeated clinical and laboratory evaluations at a regular follow-up with an average of 26 months from baseline. Low-grade inflammation was defined as plasma high-sensitivity C-Reactive Protein (CRP) concentrations > 3 mg/L. The outcome was the incidence of low-grade inflammation evaluated by the time of the second clinical evaluation. Results: The incidence of low-grade inflammation was more frequently observed in the BDI+ group compared to the BDI- group (20.9% vs. 11.4%; p = 0.001). After adjusting for sex, age, waist circumference, body mass index, levels of physical activity, smoking, and prevalence of metabolic syndrome, persistent depressive symptoms remained an independent predictor of low-grade inflammation onset (OR = 1.76; 95% CI: 1.03-3.02; p = 0.04). Conclusions: Persistent depressive symptoms were independently associated with low-grade inflammation onset among healthy individuals.

https://doi.org/10.5935/abc.20170080 1586 downloads

The population-based burden of influenza-associated hospitalization in rural western Kenya, 2007-2009
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Feikin, Daniel R

; Ope, Maurice O

; Aura, Barrack

; Fuller, James A

; Gikunju, Stella

; Vulule, John

; Ng'ang'a, Zipporah

; Njenga, M Kariuki

; Breiman, Robert F

; Katz, Mark

Bulletin of the World Health Organization

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apr 2012, Volume 90 N. 4 Pages 256 - 263A

Abstract: En Es Fr | Text: En Es Fr | PDF: En | PDF: Es | PDF: Fr

OBJECTIVE: To estimate the burden and age-specific rates of influenza-associated hospitalization in rural western Kenya. METHODS: All 3924 patients with respiratory illness (defined as acute cough, difficulty in breathing or pleuritic chest pain) who were hospitalized between June 2007 and May 2009 in any inpatient health facility in the Kenyan district of Bondo were enrolled. Nasopharyngeal and oropharyngeal swabs were collected and tested for influenza viruses using real-time reverse transcriptase polymerase chain reaction (RT-PCR). In the calculation of annual rates, adjustments were made for enrolled patients who did not have swabs tested for influenza virus. FINDINGS: Of the 2079 patients with tested swabs, infection with influenza virus was confirmed in 204 (10%); 176, 27 and 1 were found to be RT-PCR-positive for influenza A virus only, influenza B virus only, and both influenza A and B viruses, respectively. Among those tested for influenza virus, 6.8% of the children aged <5 years and 14.0% of the patients aged >5 years were found positive. The case-fatality rate among admitted patients with PCR-confirmed infection with influenza virus was 2.0%. The annual rate of hospitalization (per 100000 population) was 699.8 among patients with respiratory illness and 56.2 among patients with influenza (with 143.7, 18.8, 55.2, 65.1 and 57.3 hospitalized patients with influenza virus per 100000 people aged <5, 5-19, 20-34, 35-49 and >50 years, respectively). CONCLUSION: In a rural district of western Kenya, the rate of influenza-associated hospitalization was highest among children aged less than 5 years.

OBJETIVO: Calcular la carga y las tasas por edades de las hospitalizaciones asociadas a la gripe en el oeste rural de Kenya. MÉTODOS: Se inscribieron los 3924 pacientes con enfermedades respiratorias (definidas como tos aguda, dificultad para respirar o dolor torácico pleurítico) hospitalizados entre junio de 2007 y mayo de 2009 en cualquier centro sanitario hospitalario del distrito keniata de Bodo. Se recogieron frotis nasofaríngeos y bucofaríngeos y se comprobó la presencia de virus de la gripe mediante una reacción en cadena de la polimerasa dirigida por ARN (transcriptasa inversa) (RT-PCR). Se llevaron a cabo ajustes para aquellos pacientes inscritos para cuyos frotis no se había realizado la prueba del virus de la gripe para realizar el cálculo de las tasas anuales. RESULTADOS: Se confirmó la presencia de una infección por virus de la gripe en 204 (10%) de los 2079 pacientes cuyos frotis se sometieron a prueba; 176, 27 y 1 casos dieron positivo en la prueba de la RT-PCR sólo para el virus gripal A, sólo para el virus gripal B y para ambos virus gripales A y B, respectivamente. El 6,8% de los niños menores de 5 años y el 14,0% de los pacientes mayores de 5 años entre los que se realizó la prueba para el virus gripal dio positivo. La tasa de letalidad entre los pacientes admitidos con una infección por el virus gripal confirmada por la prueba de la PCR fue del 2,0% La tasa anual de hospitalizaciones (por cada 100 000 habitantes) fue de 699,8 entre pacientes con enfermedades respiratorias y de 56,2 entre los pacientes con gripe (con 143,7, 18,8, 55,2, 65,1 y 57,3 pacientes hospitalizados con virus gripal por cada 100 000 habitantes con edades menores de 5, comprendidas entre 5-19, 20-34, 35-49 y más de 50 años, respectivamente). CONCLUSIÓN: En un distrito rural del oeste de Kenya, la tasa de hospitalizaciones asociadas a la gripe fue más alta entre los niños menores de 5 años.

OBJECTIF: Estimer les taux spécifiques par âge et par charge de l'hospitalisation liée à la grippe dans les régions rurales de l'ouest du Kenya. MÉTHODES: Tous les 3924 patients souffrant de maladie respiratoire (définies comme toux aiguë, difficulté respiratoire ou douleur de poitrine pleurétique) qui ont été hospitalisés entre juin 2007 et mai 2009 dans tous les établissements hospitaliers du district du Bondo, au Kenya, ont été inscrits. Des prélèvements nasopharyngés et oropharyngés ont été rassemblés et testés pour les virus de la grippe au moyen d'une transcription inverse et amplification en chaîne par polymérase en temps réel (RT-PCR). Dans le calcul des taux annuels, des ajustements ont été faits pour les patients inscrits qui n'ont pas eu de prélèvements testés pour le virus de la grippe. RÉSULTATS: Des 2079 patients avec prélèvements testés, l'infection au virus de la grippe a été confirmée dans 204 (10%) des cas; 176, 27 et 1 cas se sont révélés RT-PCR positifs pour, respectivement, le virus de la grippe A uniquement, le virus de la grippe B uniquement, les virus des deux grippes A et B. Parmi les personnes testées pour le virus de la grippe, 6,8% des enfants âgés de <5 ans et 14,0% des patients âgés de 5 ans ou plus se sont révélés positifs. Le taux de létalité parmi les patients admis avec infection confirmée PCR au virus de la grippe était de 2.0%. Le taux annuel d'hospitalisation (par 100 000 habitants) était de 699,8 parmi les patients souffrant de maladie respiratoire et de 56,2 parmi les patients souffrant de la grippe (avec 143,7, 18,8, 55,2, 65,1 et 57,3 des patients hospitalisés avec le virus de la grippe par 100 000 personnes âgés de respectivement <5, 5-19, 20-34, 35-49 et >50 ans). CONCLUSION: Dans une région rurale de l'ouest du Kenya, le taux d'hospitalisation liée à la grippe était plus élevé parmi les enfants âgés de moins de 5 ans.

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Schistosoma mansoni: a method for inducing resistance to praziquantel using infected Biomphalaria glabrata snails
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Couto, Flávia FB

; Coelho, Paulo Marcos Z

; Araújo, Neusa

; Kusel, John R

; Katz, Naftale

; Jannotti-Passos, Liana K

; Mattos, Ana Carolina A

Memórias do Instituto Oswaldo Cruz

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mar 2011, Volume 106 N. 2 Pages 153 - 157

Abstract: En | Text: En | PDF: En

To elucidate the mechanisms of antischistosoma resistance, drug-resistant Schistosoma mansoni laboratory isolates are essential. We developed a new method for inducing resistance to praziquantel (PZQ) using successive drug treatments of Biomphalaria glabrata snails infected with S. mansoni. Infected B. glabrata were treated three times with 100 mg/kg PZQ for five consecutive days with a one-week interval between them. After the treatment, the cercariae (LE-PZQ) produced from these snails and the LE strains (susceptible) were used to infect mice. Forty-five days after infection, mice were treated with 200, 400 or 800 mg/kg PZQ. Thirty days post-treatment, we observed that the mean number of worms recovered by perfusion was significantly higher in the group of mice infected with the LE-PZQ isolate treated with 200 and 400 mg/kg in comparison to the LE strain with the same treatment. Moreover, there was a significant difference between the ED50 (effective dose required to kill 50% of the worms) of the LE-PZQ isolate (362 mg/kg) and the LE strain (68 mg/kg). In the in vitro assays, the worms of the LE-PZQ isolate were also less susceptible to PZQ. Thus, the use of infected snails as an experimental model for development of resistance to S. mansoni is effective, fast, simple and cheap.

3192 downloads

A randomized crossover clinical study showing that methylphenidate-SODAS improves attention-deficit/hyperactivity disorder symptoms in adolescents with substance use disorder
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Szobot, C.M.

; Rohde, L.A.

; Katz, B.

; Ruaro, P.

; Schaefer, T.

; Walcher, M.

; Bukstein, O.

; Pechansky, F.

Brazilian Journal of Medical and Biological Research

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mar 2008, Volume 41 N. 3 Pages 250 - 257

Abstract: En | Text: En | PDF: En

Our objective was to evaluate the effectiveness of a long-acting formulation of methylphenidate (MPH-SODAS) on attention-deficit/hyperactivity disorder (ADHD) symptoms in an outpatient sample of adolescents with ADHD and substance use disorders (SUD). Secondary goals were to evaluate the tolerability and impact on drug use of MPH-SODAS. This was a 6-week, single-blind, placebo-controlled crossover study assessing efficacy of escalated doses of MPH-SODAS on ADHD symptoms in 16 adolescents with ADHD/SUD. Participants were randomly allocated to either group A (weeks 1-3 on MPH-SODAS, weeks 4-6 on placebo) or group B (reverse order). The primary outcome measures were the Swanson, Nolan and Pelham Scale, version IV (SNAP-IV) and the Clinical Global Impression Scale (CGI). We also evaluated the adverse effects of MPH-SODAS using the Barkley Side Effect Rating Scale and subject reports of drug use during the study. The sample consisted of marijuana (N = 16; 100%) and cocaine users (N = 7; 43.8%). Subjects had a significantly greater reduction in SNAP-IV and CGI scores (P < 0.001 for all analyses) during MPH-SODAS treatment compared to placebo. No significant effects for period or sequence were found in analyses with the SNAP-IV and CGI scales. There was no significant effect on drug use. MPH-SODAS was well tolerated but was associated with more severe appetite reduction than placebo (P < 0.001). MPH-SODAS was more effective than placebo in reducing ADHD symptoms in a non-abstinent outpatient sample of adolescents with comorbid SUD. Randomized clinical trials, with larger samples and SUD intervention, are recommended.

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Ketoconazole therapy: an efficacious alternative to achieve eucortisolism in patients with Cushing&'s syndrome
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Moncet, Daniel

; Morando, Daniel J.

; Pitoia, Fabián

; Katz, Silvia B.

; Rossi, María A.

; Bruno, Oscar D.

Medicina (Buenos Aires)

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feb 2007, Volume 67 N. 1 Pages 26 - 31

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Cushing&'s syndrome (CS) is a serious condition requiring drug management in diverse clinical settings. Fifty four patients (44 females, 10 males) with CS, aged 14-63, received ketoconazole (KTZ) prior to surgery (n= 27), as complementary therapy after surgery and/or radiotherapy (n= 16), or as primary treatment (n= 11). It was given at a 600 (500 - 600) mg/day (median - CI95) maintenance dose for periods ranging from 15 days to 13 years. Clinical signs, hepatic enzymes and urinary free cortisol (UFC) were evaluated before and during KTZ treatment. UFC normalised or decreased to subnormal values in 85% of the patients, in 5 to 150 days after starting treatment; although failing to normalise, UFC decreased to 12-48% of pre-treatment values in the remaining patients. Clinical signs improved throughout. Side effects were adrenal insufficiency (18.5%), reversible hepatic toxicity (11%), allergic skin rash (5.5%) and gastric intolerance (3.7%); in 11% of patients, an "escape phenomenon" was observed. Twenty-four out of the total (44.4%) were treated for prolonged periods, from one up to 13 years. In conclusion, this study confirms that KTZ is an effective and generally well tolerated treatment for CS particularly: a) shortly before surgery, b) because of persistent hypercortisolism after surgery or awaiting the results of radiotherapy, c) as a reasonable option in patients with CS of unknown aetiology and, d) as long-term therapy in any case of unsolved hypercortisolism after failure of current treatments.

El síndrome de Cushing (SC) es un trastorno grave que requiere frecuentemente tratamiento medicamentoso. Cincuenta y cuatro pacientes (44 mujeres, 10 varones) de 14-63 años de edad con SC, recibieron ketoconazol (KTZ) previo a cirugía (n=27), como complemento luego de cirugía y/o radioterapia (n=16), o como tratamiento primario (n=11). La dosis de mantenimiento fue de 600 (500 - 600) mg/día (mediana-IC95) durante 15 días a 13 años. Los signos clínicos, hepatograma y cortisol libre urinario (CLU) fueron evaluados antes y durante tratamiento con KNZ. El CLU cayó a valores normales o subnormales en 85% de los pacientes, 5 a 150 días luego de iniciar el tratamiento; aún sin normalizar, el CLU disminuyó a 12-48% de los valores pre-tratamiento en el resto de los pacientes acompañándose de mejoría de los signos clínicos. Los efectos colaterales fueron: insuficiencia adrenal (18.5%), toxicidad hepática reversible (11%), "rash" cutáneo (5.5%) e intolerancia gástrica (3.7%); en 11% de los pacientes se observó un fenómeno de "escape". Veinticuatro pacientes (44.4%) fueron tratados por períodos prolongados, de uno a trece años. Este estudio confirma que el KTZ constituye un tratamiento eficaz y generalmente bien tolerado del SC, en particular: a) como preparación para cirugía b) en casos de hipercortisolismo residual luego de cirugía o en espera de resultados de radioterapia, c) como una alternativa razonable en pacientes con SC de origen desconocido y, d) como tratamiento crónico en casos de hipercortisolismo no resuelto luego de fracaso de las terapéuticas habituales.

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Desejo de informação e participação nas decisões terapêuticas em caso de doenças graves em pacientes atendidos em um hospital universitário
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Gulinelli, André

; Aisawa, Rubens K.

; Konno, Sérgio N.

; Morinaga, Christian V.

; Costardi, Wagner L.

; Antonio, Rodrigo O.

; Dumarco, Rodrigo B.

; Moino, Renata M.

; Katz, Márcio

; Giavarotti, Sandro

; Skarbnik, Allan P.Z.

; Forcione, Cyntia S.

; Chiba, Toshio

; Martins, Mílton A.

Revista da Associação Médica Brasileira

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2004, Volume 50 N. 1 Pages 41 - 47

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

OBJETIVO: Avaliar o desejo de pacientes serem informados sobre diagnóstico de doenças graves, de informação às suas famílias e de participação nas decisões terapêuticas. MÉTODOS: 363 pessoas atendidas no ambulatório ou internadas na enfermaria de um serviço universitário de Clínica Geral foram entrevistadas. O questionário continha perguntas sobre desejo de ser informado e de que familiares também fossem informados em casos de diagnósticos de câncer e síndrome da imunodeficiência adquirida (Aids) e de ser informado e participar de decisões terapêuticas em caso de tumores abdominais. RESULTADOS: Homens (96,1%) e mulheres (92,6%) mostraram desejo de serem informados do diagnóstico de câncer e 87,7% dos homens e 84,2% das mulheres desejaram que sua família também fosse informada; 94,2% dos homens e 91% das mulheres afirmaram querer saber do diagnóstico de Aids. Enquanto 86% das mulheres e 76,6% dos homens mostraram desejo de serem informados das opções terapêuticas em caso de tumor abdominal, apenas 58,5% das mulheres e 39,6% dos homens desejaram opinar sobre o tratamento. O desejo de participar das decisões terapêuticas foi menor nos homens, nas pessoas com mais de 60 anos e em quem estava internado (p<0.05). CONCLUSÕES: A grande maioria da população que procura um hospital universitário deseja ser informada sobre suas condições de saúde, incluindo eventuais diagnósticos de doenças graves. Por outro lado, existem vínculos familiares intensos, sendo que os pacientes desejam, também, que suas famílias sejam informadas.

BACKGROUND: The purpose of our study was to evaluate the desire of the patients on being informed about diagnosis of severe diseases, the desire to have their families informed about this situation and to participate in therapeutic decisions. METHODS: 363 patients (outpatients and inpatients) of a General Internal Medicine division of a University Hospital were interviewed. The questionnaire contained specific questions on their desire to be informed of the diagnosis in case of cancer or AIDS and on their desire to have their families informed as well. Specific questions on whether they wanted to be informed of and participate of the therapeutic discussion process in case of abdominal tumors were also included. RESULTS: 96.1% of men and 92.6% of women showed the desire of being informed in case of cancer diagnosis and 87.7% of men and 84.2% of women wanted to have their families informed; 94.2% of men and 91% of women wanted to know the diagnosis of AIDS. While 86% of women and 76.6% of men wanted be informed in the case of a diagnosis of an abdominal tumor, only 58.5% of women and 39.6% of men wanted to give their opinion about in the case of different therapeutic alternatives. The desire to participate in therapeutic decisions was significantly lower (p<0.05) in men, people older than 60 years and inpatients. CONCLUSIONS: Our results showed that the great majority of the population that seeks for medical support in a Brazilian university hospital wishes to be informed on this health condition, even in case of serious illness. In addition, there are intense familiar bonds that make patients want to have their families also informed.

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RE-EVALUATION OF SCHISTOSOMIASIS MANSONI IN MINAS GERAIS, BRAZIL. III. "NOROESTE DE MINAS" MESOREGION
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CARVALHO, Omar S.

; MASSARA, Cristiano L.

; GUERRA, Henrique L.

; CAMPOS, Yoná R.

; CALDEIRA, Roberta L.

; CHAVES, Adelú

; KATZ, Naftale

Revista do Instituto de Medicina Tropical de São Paulo

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sep 1998, Volume 40 N. 5

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Com o objetivo de verificar a possível presença da esquistossomose mansoni na mesorregião Noroeste de Minas, área do estado de Minas Gerais até o momento considerada indene para aquela parasitose, foi realizado um levantamento malacológico e um diagnóstico coproscópico nos 13 municípios da mesorregião. Foram coletados e examinados 3.627 planorbídeos, identificados como Biomphalaria straminea em sete municípios (Unaí, Bonfinópolis de Minas, Paracatu, João Pinheiro, Vazante, Lagamar e Lagoa Grande) e B. peregrina em um ( Presidente Olegário). Os moluscos estavam negativos para S. mansoni. O exame coproscópico, pelo método Kato-Katz, foi realizado em 3.283 estudantes do 1o grau da rede estadual de ensino. Quatro estudantes foram diagnosticados com esquistossomose nos municípios de Buritis, Formoso, Paracatu e Unaí. Entretanto, nenhum dos casos foi considerado autóctone. Podemos concluir que a mesorregião do Noroeste de Minas continua livre da esquistossomose, mas a presença de hospedeiros intermediários de S. mansoni, associados a migrantes portadores da doença enfatiza a necessidade de implantação de um programa de vigilância epidemiológica na mesorregião Noroeste de Minas com o objetivo de prevenir a introdução da esquistossomose.

This study was conducted to assess the presence of schistosomiasis mansoni in the "Noroeste de Minas" mesoregion, an area considered non-endemic. A malacologic survey and parasitologic stool examinations were undertaken in 13 municipalities of the mesoregion. A sample of 3,283 primary school students was submitted to fecal examination by the Kato-Katz method. A total of 3,627 planorbids was collected and examined. The molluscs were identified as Biomphalaria straminea in seven municipalities (Unaí, Bonfinópolis de Minas, Paracatu, João Pinheiro, Vazante, Lagamar and Lagoa Grande) and as Biomphalaria peregrina in one (Presidente Olegário). All planorbids were negative for Schistosoma mansoni. Four students were diagnosed with schistosomiasis in the municipalities of Buritis, Formoso, Paracatu and Unaí, but none of these cases was considered autochthonous. The data obtained indicate that the "Noroeste de Minas" mesoregion continues to be non-endemic for schistosomiasis mansoni, although the presence of intermediate hosts associated with parasitized individuals emphasizes the need for epidemiological surveillance of schistosomiasis in this mesoregion.

2380 downloads

10.

Pulmonary manifestations in the initial phase of schistosomiasis mansoni
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Rocha, Manoel Otávio C.

; Rocha, Regina Lunardi

; Pedroso, Ênio Roberto P.

; Greco, Dirceu B.

; Ferreira, Cid Sérgio

; Lambertucci, José Roberto

; Katz, Naftale

; Rocha, Roberto S

; Rezende, Dilermando F.

; Neves, Jayme

Revista do Instituto de Medicina Tropical de São Paulo

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aug 1995, Volume 37 N. 4 Pages 311 - 318

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Foram estudadas as alterações clínicas e radiológicas pulmonares da fase inicial da esquistossomose mansoni em 30 indivíduos previamente sadios, que se infectaram simultaneamente. Os achados foram comparados aos de um grupo - controle e relacionados a possíveis fatores patogenéticos como carga parasitária, eosinofilia sangüínea e área de reação intradérmica imediata, esta como estimativa de IgE ligada a mastócito. As manifestações pulmonares foram de intensidade leve ou moderada, sendo a tosse seca o sintoma mais comum. As alterações radiológicas significativas constaram de espessamento de paredes brônquicas, micronodulação em rosário e micronodulação esparsa, localizadas predominantemente nas porções inferiores dos campos pulmonares. Verificou-se associação significativa de sibilos e área da reação intradérmica imediata, bem como entre o número de eosinófilos sangüíneos e a ocorrência de alterações radiológicas tomadas em conjunto. Houve correlação entre a carga parasitária, expressa pelo número de ovos eliminados nas fezes, e a presença de sibilos, dor torácica e micronodulação em rosário.

The clinical and radiological pulmonary manifestations in the initial phase of schistosomiasis mansoni were studied in thirty previously healthy individuals who were simultaneously infected. The findings were compared with those concerning a control group and related to possible pathogenetic factors. The respiratory manifestations were of light or of moderate intensity, the dry cough being the most common symptom. The significant radiological alterations were: thickening of bronchial walls and beaded micronodulation, predominantly localized in the lower pulmonary fields. It was observed significant association between wheezing and IgE levels, estimated by the area of immediate intradermal reaction, as well as between the number of blood eosinophils and the occurrence of radiological changes. Moreover, there was correlation between the worm burden and the presence of wheezing, thoracic pain and beaded micronodulation. Thus, the clinical and radiological pulmonary manifestations described are significant part of the initial phase of schistosomiasis mansoni and present the worm burden, eosinophilia and levels of IgE as probable pathogenetic factors.

1868 downloads

11.

Schistosomiasis mansoni in the region of the Triângulo Mineiro, State of Minas Gerais, Brazil
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Carvalho, Omar dos Santos

; Massara, Cristiano Lara

; Silveira Neto, Horacio Velloso

; Alvarenga, Andréa Gersen

; Vidigal, Teofânia H. D. Amorim

; Guerra, Henrique L.

; Santos, Maria Angela A.

; Chaves, Adelú

; Katz, Naftale

Memórias do Instituto Oswaldo Cruz

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dec 1994, Volume 89 N. 4 Pages 509 - 512

Abstract: En | Text: En | PDF: En

In order to reevaluate the possible presence of schistosomiasis mansoni in the Triângulo Mineiro, one of the areas of the State of Minas Gerais where this parasite is not commonly found, malacological survey and fecal examinations were undertaken in the region between October 1990 and June 1992. A sample of 7,032 1st grade school children from 29 counties had their feces examined using the Kato-Katz method. Amongst the children examined, two from Planura and one from each countie of Capinópolis, Conceição das Alagoas, Uberaba, Uberlândia, Prata and Gurinhatã were positive for Schistosoma mansoni. None of the children were identified as being autoctonous cases. In the malacological survey, 5,406 planorbid snails were examined. The specimens were identified morphologically and examined for S. mansoni by squashing between glass plates. The species were identified as Biomphalaria tenagophila in three counties, as B. straminea in ten and B. intermedia in 16. No snails were found in eight other counties studies. The snails were found to be negative for S. mansoni. The presence of intermediate hosts for S. mansoni, associated with parasitized individuals emphasizes the necessity of epidemiological surveillance for schistosomiasis in the region of Triângulo in the State of Minas Gerais.

1801 downloads

12.

Ensaios preliminares do Guaiacum officinale L. como moluscicida
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Mendes, Nelymar Martineli

; Gómez, José D.

; Araújo, Neusa

; Zani, Carlos Leomar

; Katz, Naftale

Revista do Instituto de Medicina Tropical de São Paulo

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dec 1993, Volume 35 N. 6 Pages 509 - 513

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Suspensões aquosas do pericarpo do fruto, da casca da raiz, das folhas e das sementes de Guaiacum officinale foram testadas como moluscicida, cercaricida e piscicida em diferentes concentrações. Em laboratório, a suspensão do pericarpo do fruto apresentou 100% de mortalidade a 100 ppm para desovas de B. glabrata, a 20 ppm para caramujos adultos de Biomphalaria glabrata, B. straminea e B. tenagophila, a 5 ppm para Lebistes reticulatus (peixes) e a 1 ppm para cercárias de Schistosoma mansoni. O extrato etanólico do pericarpo do fruto não foi ativo para caramujo adulto de B. glabrata. As doses letais para 90% dos caramujos adultos (DL90), após 24 horas de exposição, usando a suspensão do pericarpo do fruto foram de: 15 ppm para B. glabrata; 14 ppm para B. straminea e 18 ppm para B. tenagophila. As DL90 das suspensões das casca da raiz, sementes e folhas contra B. glabrata foram de 57, 33 e 15 ppm, respectivamente. No campo, coma suspensão do pericarpo do fruto a mortalidade de caramujos adultos de B. glabrata foi de 68% a 20 ppm e 100% a 40 ppm

Aqueous suspensions of fruit's pericarp, leaves, root's bark and seeds of Guaiacum officinale were tested at different concentrations as molluscicide, cercaricide and piscicide. In the laboratory the suspension of fruit's pericarp produced 100% mortality for egg masses of B. glabrata at 100 ppm, for adult snails of Biomphalaria glabrata, B. straminea and B. tenagophila at 20 ppm, for Lebistes reticulatus (fishes) at 5 ppm and Schistosoma mansoni's cercariae at 1 ppm. The ethanolic extract of fruit's pericarp was not active against adult snails of B. glabrata. The letal dose for adult snails(DL90) of the aqueous suspension of fruit's pericarp after 24 hours exposure, were: 15 ppm for B. glabrata; 14 ppm for B. straminea and 18 ppm for B. tenagophila. The DL90 of aqueous suspensions of root's bark, seeds and leaves were 57 ppm, 33 ppm and 15 ppm, respectively. In the field, B. glabrata adult snail mortality was 68% at 20 ppm and 100% at 40 ppm, when using suspension of fruit's pericarp

2003 downloads

13.

Esquistossomose mansoni no sudoeste do Estado de Minas Gerais (Brasil)
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Carvalho, Omar dos Santos

; Massara, Cristiano Lara

; Rocha, Roberto Sena

; Katz, Naftale

Revista de Saúde Pública

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aug 1989, Volume 23 N. 4 Pages 341 - 344

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

É descrito um foco de esquistossomose mansoni, no Município de Passos, sudoeste do Estado de Minas Gerais, região até agora considerada livre da endemia. Relata-se a presença de Biomphalaria glabrata parasitada por Schistosoma mansoni, em um clube campestre, nas imediações da cidade, além de quatro crianças, residentes neste clube, com esquistossomose autóctone. Observa-se ainda, a existência de B. straminea, não infectada, nos tanques da Estação de Hidrobiologia e Piscicultura de Furnas. É discutida a importância epidemiológica da esquistossomose para a região.

A new focus of schisiosomiasis mansoni at Passos, a town in the Southwest of the State of Minas Gerais (Brazil), region until now considered free of the disease is reported. Malacological surveys showed Biophalaria glabrata naturally infected with Schistosoma mansoni in a country club near Passos. All B. straminea captured at the pisciculture station of the Furnas hydroeletric dam were negative. Six out of seven individuals living in the country club were found to be infected with S. mansoni, including four children who had never been out of Passos. The epidemiological importance of these findings is discussed.

1081 downloads

14.

Esquistossomose mansoni no sudoeste do Estado de Minas Gerais (Brasil)
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Carvalho, Omar dos Santos

; Massara, Cristiano Lara

; Rocha, Roberto Sena

; Katz, Naftale

Revista de Saúde Pública

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aug 1989, Volume 23 N. 4 Pages 341 - 344

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

2855 downloads

15.

Atividade moluscicida do extrato butílico de Phytolaca dodecandra (Endod) sobre Biomphalaria glabrata
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Souza, Cecília Pereira de

; Mendes, Nelimar Martinelli

; Araújo, Neusa

; Katz, Naftale

Memórias do Instituto Oswaldo Cruz

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sep 1987, Volume 82 N. 3 Pages 345 - 349

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O extrato butílico da Phytolacca dodecandra (tipo 44) obtido de frutos procedentes da Etiópia, foi testado como moluscicida em nosso laboratório e no campo. As concentrações letais, CL90, com 24 horas de exposição, para Biomphalaria glabrata adulta, recém-eclodidas e desovadas foram de 4,5, 23,0 e 102,0 ppm, respectivamente. Para peixes, Lebistes reticulatus, a CL90 foi de 2,0 ppm. Esses resultados foram semelhantes aos obtidos por Lemma em 1984, na Etiópia. Em dois criadouros com água parada, tratados com 10ppm de estrato butílico e 3ppm de niclosamida, ocorreu 84,0 e 100,0% de mortalidade B. glabrata, respectivamente. Os dois produtos foram tóxicos para peixes (L. reticulatus) no campo. É discutida a possibilidade do uso de moluscidas de origem vegetal, como alternativa para o combate a focos de esquistossomose no Brasil.

A buthanol extract of Phytolacca dodecandra (type 44) obtained from Ethiopia berries, was tested as molluscicide in our laboratory and in the field. The lethal dose (LD90) for adult snails, newly hatched and egg-masses of Biomphalaria glabrata, in 24 hours exposure, were of 4.5, 23.0 and 102.0 ppm respectively. The LD90 for the fish Lebistes reticulatus was of 2.0 ppm. These results are similar to those of Lemma (1984) in Ethiopia. In two water ponds treated with 10 ppm of the buthanol extract or 3 ppm of niclosamide the mortality rates of B. glabrata were of 84.6 and 100.0%, respectively. Both treatments were toxic for L. reticulatus in the field trials. The possibility of using molluscicides derived from plants is discussed as an alternative for treatment of schistosomiasis foci in Brazil.

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