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RESUMO Objetivo: Inquérito nacional de cobertura vacinal aos 12 e 24 meses de idade foi realizado para investigar as quedas nas coberturas a partir de 2016. Métodos: Amostra de 37.836 nascidos vivos das coortes de 2017 e 2018 residentes nas capitais, Distrito Federal (DF) e 12 cidades com mais de 100 mil habitantes, acompanhados nos primeiros 24 meses por registros nas cadernetas de vacinação. Setores censitários foram estratificados segundo condições socioeconômicas, e o mesmo número de crianças foi incluído para cada estrato. Calcularem-se coberturas vacinais de cada vacina e coberturas completas aos 12 e 24 meses, doses aplicadas, válidas e oportunas. Fatores familiares, maternos e da criança associados à cobertura foram pesquisados. Os motivos para não vacinar analisados foram: contraindicações médicas, dificuldades de acesso, problemas no funcionamento do programa e hesitação vacinal. Resultados: Os resultados preliminares mostram que menos de 1% das crianças não foram vacinadas, as coberturas pelo esquema completo são menores que 75% em todas as capitais e no DF, as vacinas com mais de uma dose perdem cobertura progressivamente, há diferenças entre os estratos socioeconômicos, favoráveis aos estratos mais altos em algumas cidades e aos estratos mais baixos em outras. Conclusão: Houve realmente redução da cobertura vacinal em todas as capitais e no DF para as crianças nascidas em 2017 e 2018, denotando piora na execução do Programa Nacional de Imunizações durante os anos de 2017 a 2019. O inquérito realizado não mensurou os impactos da pandemia de COVID-19 que podem ter reduzido ainda mais as coberturas vacinais.

ABSTRACT Objective: The national vaccination coverage survey on full vaccination at 12 and 24 months of age was carried out to investigate drops in coverage as of 2016. Methods: A sample of 37,836 live births from the 2017 or 2018 cohorts living in capital cities, the Federal District, and 12 inner cities with 100 thousand inhabitants were followed for the first 24 months through vaccine record cards. Census tracts stratified according to socioeconomic levels had the same number of children included in each stratum. Coverage for each vaccine, full vaccination at 12 and 24 months and number of doses administered, valid and timely, were calculated. Family, maternal and child factors associated with coverage were surveyed. The reasons for not vaccinating analyzed were: medical contraindications, access difficulties, problems with the program, and vaccine hesitancy. Results: Preliminary results showed that less than 1% of children were not vaccinated, full coverage was less than 75% at all capitals and the Federal District, vaccines requiring more than one dose progressively lost coverage, and there were inequalities among socioeconomic strata, favorable to the highest level in some cities and to the lowest in others. Conclusion: There was an actual reduction in full vaccination in all capitals and the Federal District for children born in 2017 and 2018, showing a deteriorating implementation of the National Immunization Program from 2017 to 2019. The survey did not measure the impacts of the COVID-19 pandemic, which may have further reduced vaccination coverage.

https://doi.org/10.1590/1980-549720230031

National Vaccine Coverage Survey 2020: methods and operational aspects
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Barata, Rita Barradas

; França, Ana Paula

; Guibu, Ione Aquemi

; Vasconcellos, Maurício Teixeira Leite de

; Moraes, José Cássio de

; Teixeira, Maria da Gloria Lima Cruz

; Domingues, Carla Magda Alan

; Borges, Maria Fernanda de Souza Oliveira

; de Azevedo, Roberta Nogueira Calandrini

; de Oliveira, Consuelo Silva

; Oliveira, Andrea de Nazaré Marvão

; Canales, Ivy Thereza

; Nascimento, Valdir

; Queiroz, Rejane Christine de Souza

; Lima, Luísa Helena de Oliveira

; Ramos Jr, Alberto Novaes

; Barbosa, Jaqueline Caracas

; Mirabal, Isabelle Ribeiro Barbosa

; Meira, Meiruska

; Antunes, Maria Bernadete de Cerqueira

; Teixeira, Maria Denise de Castro

; Gurgel, Ricardo Queiroz

; de Carvalho, Martha Suely Itaparica

; Cesar, Tayñana

; Maciel, Ethel Leonor Noia

; da Gama, Silvana Granado Nogueira

; Luhm, Karin Regina

; Boing, Antônio Fernando

; Mengue, Sotero Serrate

; de Oliveira, Sandra Maria do Valle Leone

; Lima, Jaqueline Costa

; Teles, Sheila Araújo

; Caetano, Karlla Antonieta Amorim

; de Araújo, Wildo Navegantes

Revista Brasileira de Epidemiologia

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2023, Volume 26 elocation e230031

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

https://doi.org/10.1590/1980-549720230031

Chronic exposure to lipopolysaccharides as an in vitro model to simulate the impaired odontogenic potential of dental pulp cells under pulpitis conditions
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MENDES SOARES, Igor Paulino

; ANSELMI, Caroline

; PIRES, Maria Luiza Barucci Araujo

; RIBEIRO, Rafael Antonio de Oliveira

; LEITE, Maria Luísa

; SOARES, Diana Gabriela

; DE SOUZA COSTA, Carlos Alberto

; HEBLING, Josimeri

Journal of Applied Oral Science

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2023, Volume 31 elocation e20230032

Abstract: En | Text: En | PDF: En

Abstract Simulating a bacterial-induced pulpitis environment in vitro may contribute to exploring mechanisms and bioactive molecules to counteract these adverse effects. Objective To investigate the chronic exposure of human dental pulp cells (HDPCs) to lipopolysaccharides (LPS) aiming to establish a cell culture protocol to simulate the impaired odontogenic potential under pulpitis conditions. Methodology HDPCs were isolated from four healthy molars of different donors and seeded in culture plates in a growth medium. After 24 h, the medium was changed to an odontogenic differentiation medium (DM) supplemented or not with E. coli LPS (0 - control, 0.1, 1, or 10 µg/mL) (n=8). The medium was renewed every two days for up to seven days, then replaced with LPS-free DM for up to 21 days. The activation of NF-κB and F-actin expression were assessed (immunofluorescence) after one and seven days. On day 7, cells were evaluated for both the gene expression (RT-qPCR) of odontogenic markers (COL1A1, ALPL, DSPP, and DMP1) and cytokines (TNF, IL1B, IL8, and IL6) and the production of reactive nitrogen (Griess) and oxygen species (Carboxy-H2DCFDA). Cell viability (alamarBlue) was evaluated weekly, and mineralization was assessed (Alizarin Red) at 14 and 21 days. Data were analyzed with ANOVA and post-hoc tests (α=5%). Results After one and seven days of exposure to LPS, NF-κB was activated in a dose-dependent fashion. LPS at 1 and 10 µg/mL concentrations down-regulated the gene expression of odontogenic markers and up-regulated cytokines. LPS at 10 µg/mL increased both the production of reactive nitrogen and oxygen species. LPS decreased cell viability seven days after the end of exposure. LPS at 1 and 10 µg/mL decreased hDPCs mineralization in a dose-dependent fashion. Conclusion The exposure to 10 µg/mL LPS for seven days creates an inflammatory environment that is able to impair by more than half the odontogenic potential of HDPCs in vitro, simulating a pulpitis-like condition.

https://doi.org/10.1590/1678-7757-2023-0032

Diretrizes curriculares do curso médico: o “GPS” precisa ser reprogramado?
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Nobre, Maria Luísa

; Leal, Daiane de França Falcão

; Marinho, Lucas

; Diniz Júnior, José

; Ferreira, Lidiane Maria de Brito Macedo

; Pinto Júnior, Francisco Edilson Leite

Revista Brasileira de Educação Médica

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2023, Volume 47 N. 2 elocation e055

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract: Introduction: The National Curriculum Guidelines (NCG) provide the directions which an undergraduate course must follow. The current NCGs for the medical course were established almost a decade ago. In this period, the world has undergone unprecedented changes and medical education cannot be left behind. Development: Medical education in Brazil has been based on three main models in the last one hundred years: the Flexnerian, Problem-Based Learning (PBL), and the current competency-based learning. The concept that the student is the center of the teaching-learning process was already emphasized in the 2014 NCG, but is this actually implemented in practice by the universities? How can the NCG help guide a more clear and effective medical education that goes beyond technical knowledge and shapes a humanized ethical professional who views the needs of both the individual and the community? Is it necessary to reroute the GPS of the NCG after so many changes caused by the Covid-19 pandemic? Conclusion: Despite the challenges faced, university faculties are increasing their involvement in implementing the changes required for today’s medical education.

Resumo: Introdução: As Diretrizes Curriculares Nacionais (DCN) constituem as direções para formação do currículo de um curso. As DCN do curso médico atual foram instituídas há quase uma década. Nesse período, o mundo passou por mudanças sem precedentes, e a educação médica não pode ficar para trás. Desenvolvimento: O ensino médico no Brasil teve nos últimos 100 anos três principais modelos de ensino: desde o flexneriano, passando pela Problem-Based Learning (PBL), até o atual ensino baseado em competências. O entendimento de que o aluno é o centro do processo ensino aprendizagem já está enfatizado nas DCN de 2014, mas será que esse conceito está sendo implementado na prática das instituições de ensino superior? Como as DCN podem ajudar a guiar de forma mais clara e efetiva uma formação médica que vá além do conhecimento técnico e lapidar um profissional humanizado, ético e com olhar para o indivíduo e para a comunidade? Será que precisaremos “reprogramar” o Global Positioning System (GPS), a rota, das DCN depois de enfrentarmos tantas mudanças decorrentes da pandemia da Covid-19? Conclusão: Apesar dos desafios, há crescente envolvimento do corpo docente das instituições de ensino superior nas melhorias necessárias para a formação médica atual.

https://doi.org/10.1590/1981-5271v47.2-20220252

Endocrine disorders in children with neurofibromatosis type 1: What to look for?
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Rangel, Maria Adriana

; Real, Marta Vila

; Santos, Fátima

; Leite, Ana Luísa

; Campos, Rosa Arménia

Nascer e Crescer

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dec 2022, Volume 31 N. 4 Pages 354 - 363

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo A neurofibromatose tipo 1 (NF1) é uma das doenças genéticas mais comuns, com uma incidência reportada de 1:3000. A condição é multissistémica e os critérios diagnósticos foram recentemente revistos como uma recomendação de consenso internacional. As características clínicas da doença evoluem lenta e progressivamente e frequentemente podem estar ausentes na primeira infância. Embora descritos há várias décadas nestas crianças, condições endócrinas e distúrbios do crescimento não estão incluídos nos critérios diagnósticos da doença. No entanto, são relativamente frequentes e podem ser a forma de apresentação de glioma da via ótica. Devido ao amplo espetro de implicações na saúde da NF1, o seguimento destas crianças é muitas vezes feito em contexto de consulta de Pediatria. O objetivo deste artigo é rever os distúrbios endócrinos mais frequentes em doentes com NF1, o que vigiar e quando referenciar os doentes à consulta de Endocrinologia pediátrica.

Abstract Neurofibromatosis type 1 (NF1) is one of the most common genetic disorders, with a reported incidence of 1:3000. The condition is multisystemic, and diagnostic criteria have been recently revised as an international consensus recommendation. The clinical features evolve slowly and progressively and may often be absent in early childhood. Disorders of growth and endocrine conditions, although described for several decades in these children, are not included in the diagnostic criteria. However, they are relatively frequent and may be the presenting feature of optic pathway glioma. Due to its wide spectrum of health implications, children with NF1 are often followed at Pediatric consultation. The aim of this article is to review the most frequent endocrine disorders in NF1 patients, what to look for, and when to refer patients to pediatric Endocrinology consultation.

https://doi.org/10.25753/birthgrowthmj.v31.i4.25986

Dermatology clinical case
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Sá, Liliana

; Pena, Teresa

; Almeida, Sónia

; Rangel, Maria Adriana

; Campos, Rosa Arménia

; Leite, Ana Luísa

Nascer e Crescer

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jun 2022, Volume 31 N. 2 Pages 178 - 180

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Multiple lentigines (LEOPARD) syndrome is an inherited autosomal dominant disorder. LEOPARD is an acronym for the most important features of the disease: multiple lentiginous lesions, abnormal electrocardiogram, ocular hypertelorism, pulmonary stenosis, genital and reproductive abnormalities, growth retardation, and sensorineural deafness. Herein is reported the case of a 14-year-old male who presented with short stature and alopecia. The mother, maternal grandmother, and aunts had multiple lentigines all over the body and hypoacusia. Systemic examination revealed short stature, alopecia reaching over 90% of the scalp, trachyonychia, multiple lentigines mostly scattered over the trunk, four café-au-lait spots, pectus excavatum, grade II/VI systolic heart murmur, and Tanner stage G2P1A1. The genetic study confirmed LEOPARD syndrome diagnosis. Early diagnosis is useful for prospective management of associated medical conditions and genetic counseling.

Resumo A síndrome de múltiplos lentigos (LEOPARD) é uma doença genética autossómica dominante. LEOPARD é um acrónimo para as características mais importantes da doença: lentigos múltiplos, anomalias de condução no eletrocardiograma, hipertelorismo ocular, estenose pulmonar, anomalias genitais, atraso de crescimento e surdez neurossensorial. Os autores descrevem o caso de um adolescente de 14 anos referenciado por baixa estatura e alopécia, com história familiar de múltiplos lentigos distribuídos pelo corpo e hipoacusia na mãe, avó materna e tias. O exame físico evidenciou baixa estatura, alopécia atingindo mais de 90% do couro cabeludo, traquioníquia, múltiplos lentigos espalhados pelo tronco, quatro manchas café-com-leite, pectus excavatum, sopro cardíaco sistólico de grau II/VI e estadio de Tanner G2P1A1. O estudo genético confirmou o diagnóstico de síndrome de LEOPARD. Um diagnóstico precoce da doença é fundamental para a gestão prospetiva de problemas médicos associados e aconselhamento genético.

https://doi.org/10.25753/birthgrowthmj.v31.i2.23217 23 downloads

Pro-inflammatory mediators expression by pulp cells following tooth whitening on restored enamel surface
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Soares, Diana Gabriela

; Sacono, Nancy Tomoko

; Ribeiro, Ana Paula Dias

; Leite, Maria Luisa

; Duque, Carla Caroline de Oliveira

; Gallinari, Marjorie de Oliveira

; Pacheco, Leandro Edgar

; Hebling, Josimeri

; Costa, Carlos Alberto de Souza

Brazilian Dental Journal

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apr 2022, Volume 33 N. 2 Pages 83 - 90

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Este trabalho teve como objetivo avaliar a influência da interface de uma restauração adesiva na difusão do peróxido de hidrogênio (H2O2), toxicidade indireta e expressão de mediadores pró-inflamatórios por células odontoblastóides, após clareamento dental em consultório. Cavidades dentárias preparadas em discos de esmalte / dentina foram restauradas com adesivo e submetidas ou não à degradação hidrolítica (HD). Um gel clareador com 35% H2O2 (WG) foi aplicado por 45 min em discos restaurados e não restaurados adaptados às câmaras pulpares artificiais dando origem aos grupos: SD- discos intactos (controle); SD / HP - Discos intactos clareados; RT / HP - discos restaurados e clareados; e RT / HD / HP - discos restaurados, clareados e submetidos a HD. Os extratos (meio de cultura + componentes WG difundidos através da interface esmalte/dentina/restauração) foram coletados e aplicados em células odontoblastóides MDPC-23. Foi avaliada a quantidade de H2O2 nos extratos, bem como a viabilidade (CV), morfologia (CM) e expressão gênica de mediadores inflamatórios (TNF-α e COX-2) pelas células pulpares expostas aos extratos (ANOVA e testes de Tukey; 5% de significância). Todos os grupos clareados apresentaram menor CV do que SD (controle; p <0,05). A maior redução CV e expressão gênica de TNF-α e COX-2 foi observada no grupo RT / HD / HP em comparação com SD / HP e RT / HP (controle; p <0,05). Alterações na CM ocorreram em todos os grupos clareados. A intensidade desses efeitos celulares teve relação direta com a quantidade de H2O2 nos extratos. Concluímos que a presença de uma cavidade contendo restauração adesiva aumenta a difusão de H2O2 após o clareamento em consultório, o que, por sua vez, aumenta a toxicidade indireta dessa terapia e desencadeia a expressão de mediadores pró-inflamatórios pelas células pulpares MDPC-23.

Abstract This paper aimed to assess the influence of adhesive restoration interface on the diffusion of hydrogen peroxide (H2O2), indirect toxicity, and pro-inflammatory mediators expression by odontoblast-like cells, after in-office tooth whitening. Dental cavities prepared in bovine enamel/dentin discs were adhesively restored and subjected or not to hydrolytic degradation (HD). A whitening gel with 35% H2O2 (WG) was applied for 45 min onto restored and non-restored specimens adapted to artificial pulp chambers giving rise to the groups: SD- intact discs (control); SD/HP- whitened intact discs; RT/HP- restored and whitened discs; and RT/HD/HP- restored and whitened discs subjected to HD. The extracts (culture medium + WG components diffused through enamel/dentin/restoration interface) were collected and applied to odontoblast-like MDPC-23 cells. The study evaluated the amount of H2O2 in the extracts, as well as the cell viability (CV), cell morphology (CM), and gene expression of inflammatory mediators (TNF-α and COX-2) by the pulp cells exposed to the extracts (ANOVA and Tukey tests; 5% significance). All whitened groups presented lower CV than SD (control; p<0.05). The highest CV reduction and gene expression of TNF-α and COX-2 was observed in the RT/HD/HP group in comparison with SD/HP and RT/HP (control; p<0.05). CM alterations occurred in all whitened groups. The intensity of these cell side effects was directly related with the amount of H2O2 in the extracts. We concluded that adhesive restoration of dental cavity increases the H2O2 diffusion after in-office whitening, enhancing the indirect toxicity of this therapy and trigger pro-inflammatory overexpression by MDPC-23 cells.

https://doi.org/10.1590/0103-6440202204688

Mortality attributed to sickle cell disease in children and adolescents in Brazil, 2000–2019
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Nascimento, Maria Isabel do

; Przibilski, Ana Luísa Ferreira

; Coelho, Carolina Sampaio Gomes

; Leite, Katyslaine Frossard de Amorim

; Makenze, Mariana

; Jesus, Stella Bayer de

Revista de Saúde Pública

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2022, Volume 56 elocation 65

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO OBJETIVO Estimar taxas e descrever tendências de mortalidade atribuídas à doença falciforme em crianças e adolescentes no Brasil, de 2000 a 2019. MÉTODOS Este é um estudo ecológico do tipo séries temporais de taxas de mortalidade que usou o método autorregressivo, proposto por Prais-Winsten, para avaliar tendências das taxas estimadas de mortes por doença falciforme em crianças e adolescentes no Brasil. Os óbitos com código D57 foram obtidos no Sistema de Informações sobre Mortalidade, considerando as faixas etárias (0–4, 5–9, 10–14, 15–19 anos) e usados para estimar taxas específicas por idade e taxas padronizadas por sexo e idade. RESULTADOS De 2000 a 2019, houve 2.422 óbitos por doença falciforme em menores de 20 anos no Brasil, com maior frequência na região Nordeste (40,46%), seguida de Sudeste (39,02%), Centro-Oeste (9,58%), Norte (7,84%) e Sul (3,10%). As principais vítimas foram pessoas de raça/cor da pele negra (78,73%). No Brasil, a taxa média padronizada global foi de 0,20/100 mil pessoa-ano, com tendência de elevação (mudança percentual anual – APC = 5,44%; intervalo de confiança – IC95% 2,57–8,39). O padrão se repetiu no sexo masculino (APC = 4,38%; IC95% 2,17–6,64) e no sexo feminino (APC = 6,96%; IC95% 3,05–11,01). A elaboração de taxas específicas por idade mostrou que a faixa até quatro anos experimentou as maiores taxas, sem distinção por região. A faixa etária de 15 e 19 anos foi a segunda mais afetada no Brasil e nas regiões Nordeste, Sudeste e Centro-Oeste. CONCLUSÃO Houve tendência de aumento dos óbitos por transtornos falciformes em crianças e adolescentes. Considerando que a magnitude dos óbitos foi mais evidente nos primeiros anos (0–4) e no final da adolescência (15–19), o estudo sugere que abordagens específicas por faixa etária podem impactar no controle dos desfechos fatais causados pela doença falciforme no Brasil.

ABSTRACT OBJECTIVE Estimate rates and describe mortality trends attributed to sickle cell disease in children and adolescents in Brazil from 2000 to 2019. METHODS This is an ecological study of the time-trend of mortality rates that used the autoregressive method, proposed by Prais-Winsten, to evaluate trends in the estimated rates of sickle cell disease deaths in children and adolescents in Brazil. Deaths with code D57 were obtained from the Mortality Information System, considering age groups (0–4, 5–9, 10–14, 15–19 years) and were used to estimate age-specific and standardized rates by gender and age. RESULTS From 2000 to 2019, Brazil had 2,422 deaths from sickle cell disease in people under 20 years of age, with higher frequency in the Northeast (40.46%), followed by the Southeast (39.02%), Midwest (9.58%), North (7.84%), and South (3.10%). The main victims were people of Black skin/race (78.73%). In Brazil, the global standardized average rate was 0.20/100,000 people-year, with an elevation trend (annual percentage change – APC = 5.44%; confidence interval – 95%CI: 2.57–8.39). The pattern was repeated in males (APC = 4.38%; 95%CI: 2.17–6.64) and females (APC = 6.96%; 95%CI: 3.05–11.01). Elaborating age-specific rates showed that the range up to four years experienced the highest rates, without distinction by region. The age group of 15 and 19 years was the second most affected in Brazil and in the Northeast, Southeast, and Midwest regions. CONCLUSION Deaths due to sickle cell disorders showed an elevation trend in children and adolescents. Considering that the magnitude of deaths was more evident in the first years (0–4) and late adolescence (15–19), the study suggests that age-specific approaches may impact the control of fatal outcomes caused by sickle cell disease in Brazil.

https://doi.org/10.11606/s1518-8787.2022056003681

Mortality attributed to sickle cell disease in children and adolescents in Brazil, 2000–2019
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Nascimento, Maria Isabel do

; Przibilski, Ana Luísa Ferreira

; Coelho, Carolina Sampaio Gomes

; Leite, Katyslaine Frossard de Amorim

; Makenze, Mariana

; Jesus, Stella Bayer de

Revista de Saúde Pública

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2022, Volume 56 elocation 65

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.11606/s1518-8787.2022056003681

10.

Projeto Integra: fortalecimento da participação social na agenda das políticas, serviços e tecnologias em saúde
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Leite, Silvana Nair

; Bermudez, Jorge Antonio Zepeda

; Melecchi, Débora

; Veiga, Adelir Rodrigues da

; Oliveira, Ana Liani Beisl

; Sousa, Artur Custódio Moreira de

; Chaves, Célia Machado Gervásio

; Manzini, Fernanda

; Dutra, Lidiane Silva

; Chaves, Luísa Arueira

; Pereira, Marco Aurélio

; Lima, Maria Eufrásia Oliveira

; Toniolo, Moysés Longinho

; Santos, Ronald Ferreira dos

; Dantas, Silvânia

; Costa, Jorge Carlos Santos da

Ciência & Saúde Coletiva

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nov 2021, Volume 26 N. 11 Pages 5589 - 5598

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo A 16ª Conferência Nacional de Saúde demonstrou o interesse do controle social em intervir sobre as políticas públicas a fim de garantir o direito às tecnologias de saúde. O projeto Integra - Integração das Políticas de Vigilância em Saúde, Assistência Farmacêutica, Ciência, Tecnologia e Inovação em Saúde -, nasce da parceria entre o Conselho Nacional de Saúde, a Escola Nacional dos Farmacêuticos e a Fundação Oswaldo Cruz (Fiocruz), com apoio da Organização Pan-Americana de Saúde (OPAS) com objetivo de fortalecimento da participação e engajamento social na temática e a integração das políticas e práticas de saúde em diferentes setores da sociedade (movimentos sociais, controle social e profissionais de saúde), tendo as diversas etapas relacionadas ao acesso aos medicamentos (pesquisa, incorporação, produção nacional e serviços) como mote principal, no cenário da pandemia de COVID-19. Oferta-se, neste projeto, capacitação para grupos de lideranças nas regiões de saúde e atividades de grande abrangência nacional e política. Espera-se alcançar o estabelecimento de uma rede intersetorial, integrada de lideranças capazes de atuar colaborativamente para a defesa do desenvolvimento da ciência, das políticas públicas, da soberania nacional e do controle social da saúde.

Abstract The 16th National Health Conference illustrated the interest of health councils to intervene in public policies in order to guarantee the right to health technologies. The INTEGRA project (Integration of policies for Health Surveillance, Pharmaceutical Care, Science, Technology, and Innovation in Health) is a partnership among the National Health Council, the National School of Pharmacists, and the Oswaldo Cruz Foundation (Fiocruz), with support from the Pan American Health Organization (PAHO), with the goal of strengthening participation and social engagement in the theme, as well as the integration of health policies and practices within different sectors of society (social movements, health councils, and health professionals), with the various stages related to the access to medicines (research, incorporation, national production, and services) being the main theme in the context of the COVID-19 pandemic. It seeks to offer training for leadership groups in the health regions and activities with a broad national and political scope, and it hopes to establish an intersectorial and integrated network of leaders capable of acting collaboratively to defend the development of science, public policies, national sovereignty, and social control of health.

https://doi.org/10.1590/1413-812320212611.18212021 1 downloads

11.

Enjolras Vampré and the character of Les Misérables
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Meira, Alex Tiburtino

; Franklin, Gustavo Leite

; Meira, Maria Luísa Pacífico Brandão

; Mota, Isabella Araújo

; Barbosa, Egberto Reis

; Teive, Hélio Afonso Ghizoni

Arquivos de Neuro-Psiquiatria

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nov 2021, Volume 79 N. 11 Pages 1035 - 1038

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Enjolras Vampré (1885-1938) foi um dos neurologistas pioneiros no Brasil cujo nome é uma homenagem a um dos personagens do livro Les Misérables (1862), escrito por Victor Hugo (1802-1885). Neste artigo, os autores apontam evidências de que os nomes coincidentes não são apenas uma questão de homenagem, mas ainda mais, a vida de Dr. Enjolras teve muitas outras semelhanças com o interessante personagem.

ABSTRACT Enjolras Vampré (1885-1938) was one of the pioneering neurologists in Brazil whose name is a tribute to one of the characters of the book Les Misérables (1862), written by Victor Hugo (1802-1885). In this article, the authors point out evidence that the coincident names were not just a matter of homage, and even more so, the life of Dr. Enjolras had many similarities with the interesting character.

https://doi.org/10.1590/0004-282x-anp-2021-0066 2 downloads

12.

Bioactivity effects of extracellular matrix proteins on apical papilla cells
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LEITE, Maria Luísa

; SOARES, Diana Gabriela

; ANOVAZZI, Giovana

; Filipe Koon Wu, MON

; BORDINI, Ester Alves Ferreira

; HEBLING, Josimeri

; DE SOUZA COSTA, Carlos Alberto

Journal of Applied Oral Science

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2021, Volume 29 elocation e20210038

Abstract: En | Text: En | PDF: En

Abstract Potent signaling agents stimulate and guide pulp tissue regeneration, especially in endodontic treatment of teeth with incomplete root formation. Objective This study evaluated the bioactive properties of low concentrations of extracellular matrix proteins on human apical papilla cells (hAPCs). Methodology Different concentrations (1, 5, and 10 µg/mL) of fibronectin (FN), laminin (LM), and type I collagen (COL) were applied to the bottom of non-treated wells of sterilized 96-well plates. Non-treated and pre-treated wells were used as negative (NC) and positive (PC) controls. After seeding the hAPCs (5×103 cells/well) on the different substrates, we assessed the following parameters: adhesion, proliferation, spreading, total collagen/type I collagen synthesis and gene expression (ITGA5, ITGAV, COL1A1, COL3A1) (ANOVA/Tukey; α=0.05). Results We observed greater attachment potential for cells on the FN substrate, with the effect depending on concentration. Concentrations of 5 and 10 µg/mL of FN yielded the highest cell proliferation, spreading and collagen synthesis values with 10 µg/mL concentration increasing the ITGA5, ITGAV, and COL1A1 expression compared with PC. LM (5 and 10 µg/mL) showed higher bioactivity values than NC, but those were lower than PC, and COL showed no bioactivity at all. Conclusion We conclude that FN at 10 µg/mL concentration exerted the most intense bioactive effects on hAPCs.

https://doi.org/10.1590/1678-7757-2021-0038 94 downloads

13.

Dose- and time-dependent effects of taxifolin on viability and mineralization markers of osteoblast-like cells
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MASSUNARI, Loiane

; RABELO, Rafaela Laruzo

; LEITE, Maria Luisa

; SOARES, Diana Gabriela

; ANOVAZZI, Giovana

; COSTA, Carlos Alberto Souza

; DUQUE, Cristiane

Brazilian Oral Research

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2021, Volume 35 elocation e140

Abstract: En | Text: En | PDF: En

Abstract The current study evaluated the effects of taxifolin treatments on the viability of osteoblast-like cells, and on the expression of early mineralization markers, as part of the ongoing search for new endodontic materials able to induce periapical healing without causing cytotoxicity. Saos-2 osteoblast-like cells were exposed to different concentrations of taxifolin (5 and 10 µM), applied as pretreatments either for 24h and 72h, or continuously throughout the experimental protocol. Cell viability using the methylthiazole tetrazolium (MTT) assay, alkaline phosphatase activity using thymolphthalein monophosphate assays, deposition of mineralized nodules using alizarin red staining, and expression of ALP and COL-1 by qPCR were determined after 6 and 13 days of treatment. The data were analyzed statistically (p<0.05). Taxifolin was not cytotoxic in the concentrations tested. Pretreatments with taxifolin for 24h and 72h at 10 µM stimulated ALP activity, and increased mineralized nodule deposition by Saos-2 cells. Continuous treatment with taxifolin was not effective in stimulating ALP activity and mineralization. ALP and COL-1 gene expression increased with taxifolin pretreatments, since the highest mRNA levels were observed after 72h of pretreatment with taxifolin at 10 µM on day 13. In conclusion, taxifolin was cytocompatible, and induced mineralization markers when applied for short periods in osteoblast-like cell culture.

https://doi.org/10.1590/1807-3107bor-2021.vol35.0140 1 downloads

14.

Projeto Integra: fortalecimento da participação social na agenda das políticas, serviços e tecnologias em saúde
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Leite, Silvana Nair

; Bermudez, Jorge Antonio Zepeda

; Melecchi, Débora

; Veiga, Adelir Rodrigues da

; Oliveira, Ana Liani Beisl

; Sousa, Artur Custódio Moreira de

; Chaves, Célia Machado Gervásio

; Manzini, Fernanda

; Dutra, Lidiane Silva

; Chaves, Luísa Arueira

; Pereira, Marco Aurélio

; Lima, Maria Eufrásia Oliveira

; Toniolo, Moysés Longinho

; Santos, Ronald Ferreira dos

; Dantas, Silvânia

; Costa, Jorge Carlos Santos da

Ciência & Saúde Coletiva

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2021, Volume 26 N. 11 Pages 5589 - 5598

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1413-812320212611.18212021

15.

GUT MICROBIOTA, PREBIOTICS, PROBIOTICS, AND SYNBIOTICS IN GASTROINTESTINAL AND LIVER DISEASES: PROCEEDINGS OF A JOINT MEETING OF THE BRAZILIAN SOCIETY OF HEPATOLOGY (SBH), BRAZILIAN NUCLEUS FOR THE STUDY OF HELICOBACTER PYLORI AND MICROBIOTA (NBEHPM), AND BRAZILIAN FEDERATION OF GASTROENTEROLOGY (FBG)
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BARBUTI, Ricardo Correa

; SCHIAVON, Leonardo Lucca

; OLIVEIRA, Cláudia P

; ALVARES-DA-SILVA, Mário Reis

; SASSAKI, Lígia Yukie

; PASSOS, Maria do Carmo F

; FARIAS, Alberto Queiroz

; BARROS, Luisa Leite

; BARRETO, Bruno Paes

; ALBUQUERQUE, Gisela Bandeira de Melo Lins de

; ALVES, Amanda Mandarino

; NAVARRO-RODRIGUEZ, Tomás

; BITTENCOURT, Paulo Lisboa

Arquivos de Gastroenterologia

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dec 2020, Volume 57 N. 4 Pages 381 - 398

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Nos últimos anos, um volume crescente de evidências indica que os microrganismos estão envolvidos na manutenção da saúde humana e também estão relacionados a várias doenças, tanto intestinais quanto extraintestinais. Alterações na microbiota intestinal parecem ser um elemento chave na patogênese de doenças hepáticas e gastrointestinais, incluindo doença hepática gordurosa não-alcoólica, doença hepática alcoólica, cirrose hepática, doenças inflamatórias intestinais, síndrome do intestino irritável e diarreia associada ao Clostridium difficile. Em 2019, a Sociedade Brasileira de Hepatologia (SBH) em colaboração com o Núcleo Brasileiro para Estudo do Helicobacter pylori e Microbiota (NBEHPM) e a Federação Brasileira de Gastroenterologia (FBG) realizaram um encontro exclusivamente voltado para a discussão sobre microbiota e uso de prebióticos, probióticos e simbióticos em doenças hepáticas e gastrointestinais. Este texto resume os principais pontos discutidos durante o evento, e tem a intenção de fornecer informações práticas sobre o assunto, abordando as descobertas mais recentes e indicando áreas para estudos futuros.

ABSTRACT Over the last years, there is growing evidence that microorganisms are involved in the maintenance of our health and are related to various diseases, both intestinal and extraintestinal. Changes in the gut microbiota appears to be a key element in the pathogenesis of hepatic and gastrointestinal disorders, including non-alcoholic fatty liver disease, alcoholic liver disease, liver cirrhosis, inflammatory bowel disease, irritable bowel syndrome, and Clostridium difficile - associated diarrhea. In 2019, the Brazilian Society of Hepatology (SBH) in cooperation with the Brazilian Nucleus for the Study of Helicobacter Pylori and Microbiota (NBEHPM), and Brazilian Federation of Gastroenterology (FBG) sponsored a joint meeting on gut microbiota and the use of prebiotics, probiotics, and synbiotics in gastrointestinal and liver diseases. This paper summarizes the proceedings of the aforementioned meeting. It is intended to provide practical information about this topic, addressing the latest discoveries and indicating areas for future studies.

https://doi.org/10.1590/s0004-2803.202000000-72 2240 downloads

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