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ABSTRACT Objective: To evaluate autoinflammatory diseases (AID) according to age at diagnosis and sex, and response to therapy in a large population. Methods: This is a cross-sectional observational study of a Latin American registry using a designed web system for data storage, collected between 2015 and 2018. Any altered findings during follow-up were recorded. The forms were translated into Portuguese and Spanish, including demographic, clinical, laboratory, genetic and treatment characteristics. Results: We included 152 patients, 51.3% male and 75% Caucasian. The median age at disease onset was 2.1 years (0–15.6 years) and median age at diagnosis 6.9 years (0–21.9 years); 111 (73%) were children (0–9 years old), and 41 (27%) were adolescents and young adults (AYA) (10–21 years old). Periodic fever, aphthous stomatitis, pharyngitis, and adenitis syndrome (PFAPA) occurred in 46/152 (30%), chronic non-bacterial osteomyelitis (CNO) in 32/152 (21%), and familial Mediterranean fever (FMF) in 24/152 (15.7%). PFAPA was significantly higher in young children than in AYA (38.7% vs. 7.3%, p<0.001), while CNO were lower (13.5% vs. 41.5%, p<0.001). The frequency of females was significantly higher in CNO (28.4% vs. 14.1%, p=0.031) and lower in FMF (8.1% vs. 23.1%, p=0.011). The most used drugs were glucocorticoids, non-steroidal anti-inflammatory drugs (NSAID), and colchicine. Glucocorticoids and colchicine treatment were used in all AID with good to moderate response. However, cryopyrin-associated periodic syndromes (CAPS) seemed unresponsive to glucocorticoids. NSAIDs and methotrexate were the main medications used to treat CNO. Conclusions: Differences among AID patients were observed in the LA population regarding sex and age at disease diagnosis.

RESUMO Objetivo: Avaliar as doenças autoinflamatórias (DAI) de acordo com sexo e idade no momento do diagnóstico e a resposta terapêutica em uma grande população. Métodos: Este é um estudo observacional transversal de um registro latino-americano que usou um sistema de dados coletados entre 2015 e 2018. Quaisquer achados alterados ao longo do acompanhamento foram registrados. Os formulários foram traduzidos para os idiomas português e espanhol, incluindo características demográficas, clínicas, laboratoriais, genéticas e de tratamento. Resultados: Incluímos 152 pacientes, sendo 51,3% do sexo masculino e 75% da raça branca. A média de idade de início da doença foi de 2,1 anos (0–15,6 anos) e a média de idade de diagnóstico 6,9 anos (0–21,9 anos); 111 (73%) eram crianças (0–9 anos) e 41 (27%) adolescentes/adultos jovens (10–21 anos). A síndrome de febre periódica, estomatite aftosa, faringite e adenite (PFAPA) ocorreu em 46/152 (30%), osteomielite não bacteriana crônica (CNO) em 32/152 (21%) e febre familiar do Mediterrâneo (FMF) em 24/152 (15,7%). A PFAPA foi significativamente maior em crianças pequenas (38,7 vs. 7,3%, p<0,001), e a CNO, em adolescentes/adultos jovens (13,5 vs. 41,5%, p<0,001). A frequência do sexo feminino foi significativamente maior na CNO (28,4 vs. 14,1%, p=0,031) e menor na FMF (8,1 vs. 23,1%, p=0,011). Os medicamentos mais utilizados foram glicocorticoides, anti-inflamatórios não esteroidais (AINE) e colchicina. O tratamento com glicocorticoides e colchicina foi usado em todas as DAI com resposta boa a moderada. No entanto, as síndromes periódicas associadas à criopirina (CAPS) pareciam não responder aos glicocorticoides. AINE e metotrexato foram os principais medicamentos utilizados no tratamento da CNO. Conclusões: Diferenças de pacientes com DAI foram observadas na população latino-americana em pacientes agrupados por sexo e idade ao diagnóstico da doença.

https://doi.org/10.1590/1984-0462/2024/42/2022184

Validation of the Demand Control Support Questionnaire for European Portuguese
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Kraus, Teresa

; Dixe, Maria dos Anjos

; Pais, Ricardo

; Theorell, Töres

; Gaspar, Pedro

; Lopes, Maria da Saudade

Portuguese Journal of Public Health

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dec 2023, Volume 41 N. 3 Pages 188 - 197

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Background: The Demand Control Support model is useful for studying work-related stress. The combination of high demand and a low level of control generates “job strain” (“job iso-strain” if poor support is added), with implications for the worker’s health and well-being. The aims of this study were to adapt, examine the factor structure of, and determine the reliability of, the Demand Control Support Questionnaire (DCSQ) short version for European Portuguese (DCSQ-PT). Methods: The scale was translated into Portuguese following a rigorous process and then applied to 501 workers from various professional sectors. An online survey was used to collect sociodemographic, professional, and Demand Control Support data. Validation was based on reliability and validity tests. Results: The mean age of the sample was 41.8 ± 10.3 years, and 50.1% of the participants were female. The results reveal good reliability (Cronbach’s alpha = 0.807) and validity. Confirmatory factor analyses demonstrated that a four-factor solution of the DCSQ-PT scale had a good fit to the data, as was the case for the original scale. The DCSQ-PT© with 16 items is composed of the following factors: social support at work; psychological demands; skill discretion; and decision authority. Conclusions: This validation allows an instrument to be obtained with 16 items for studying work-related stress in Portuguese workers.

Resumo Introdução: O Demand Controle Support Model é indicado para estudar o stress relacionado com o trabalho. A combinação de um alto nível de exigência laboral com um baixo nível de controle e suporte, geram “tensão laboral”, com implicações para a saúde e bem-estar dos trabalhadores. Os objetivos deste estudo foram adaptar, avaliar a estrutura fatorial e determinar a fidelidade da versão breve da escala Demand Control Support Questionnaire (DCSQ-PT) para português europeu. Método: A escala foi inicialmente traduzida para o português europeu seguindo as guidelines internacionais, sendo posteriormente aplicada a 510 trabalhadores de vários setores de atividade profissional. Os dados foram colhidos através da aplicação online de um questionário, constituído por dados sociodemográficos, profissionais e da escala Demand Control Support Questionnaire (DCSQ-PT). Para a determinação das características psicométricas foram utilizados testes de consistência interna e de analise fatorial. Resultados: A idade média da amostra foi de 41.8 ± 10.3 anos sendo 50.1% do sexo feminino. Os resultados revelaram boa fiabilidade (Alfa de Cronbach = 0.807) e validade. A análise fatorial confirmatória da escala DCSQ-PT demonstrou uma solução de quatro fatores, semelhante à escala original sendo que os 16 itens da DCSQ-PT© agregam-se nos seguintes fatores: Apoio Social no trabalho; Exigências Psicológicas; Desenvolvimento de Habilidades; Autoridade para a tomada de Decisão. Conclusões: Os resultados permitem afirmar que a escala DCSQ-PT é um instrumento adequado para o estudo do stress de trabalhadores portugueses

https://doi.org/10.1159/000534474

Information Society and Taxation: The Case of E-Commerce
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Cunha Lopes, Teresa Maria Geraldes Da

; Ochoa de León, Martha

Mexican law review

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jun 2023, Volume 15 N. 2 Pages 97 - 116

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

ABSTRACT The use of information technologies in business activities has led to significant changes, some of them of a legal nature. Among them, those related to taxation have gained relevance, since electronic commerce generates many financial transactions that may result in taxation. Therefore, these new manifestations of online economic activities bring about the problem of the concept of “functional” sovereignty and various issues related to fiscal responsibility for e-commerce. This forced us to analyze the new solutions adapted to the delocalized nature of electronic commerce, as the European Union did with the now called “Amazon Tax.” In this article, we will try to make a comparative study, between Mexico and the European Union, seeking to clarify the historical evolution, as well as the pragmatic solutions and regulatory problems posed by the taxation of e-commerce.

RESUMEN El uso de las tecnologías de la información en la actividad empresarial ha supuesto importantes cambios, algunos de ellos de carácter legal. Y entre ellos cobran importancia los relacionados con la tributación, ya que el comercio electrónico genera muchas transacciones financieras que pueden dar lugar a tributación. Por lo tanto, estas nuevas manifestaciones de actividades económicas en línea introducen el problema del concepto de soberanía “funcional” y varias cuestiones relacionadas con la responsabilidad fiscal para el comercio electrónico. Eso nos obligó a analizar las nuevas soluciones adaptadas al carácter deslocalizado del comercio electrónico, como hizo la Unión Europea con la ahora denominada “Tarifa Amazon”. En este artículo intentaremos hacer un estudio comparativo, entre México y la Unión Europea, buscando esclarecer la evolución histórica y las soluciones pragmáticas y los problemas regulatorios que plantea la tributación del Comercio Electrónico.

https://doi.org/10.22201/iij.24485306e.2023.2.17619

La retroalimentación digital en la didáctica de la escritura en el ecosistema de la Educación Superior
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Mateo Girona, Maria Teresa

; Lopes Ferrero, Carmen

; Jarpa, Marcela

; Gonzalez Lillo, Emmy Antonella

Perspectiva Educacional

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2023, Volume 62 N. 2 Pages 1 - 4

Abstract: Es | Text: Es | PDF: Es

PREDICTION OF THE GEOGRAPHIC DISTRIBUTION AND CONSERVATION OF AMAZONIAN PALM TREES Astrocaryum acaule MART. AND Astrocaryum aculeatum MART.
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Cordeiro, Adriel Lira

; Tomaz, Jennifer Souza

; Bezerra, Caroline de Souza

; Meneses, Carlos Henrique Salvino Gadêlha

; Aguiar, Ananda Virgínia de

; Wrege, Marcos Silveira

; Ramos, Santiago Linorio Ferreyra

; Lopes, Ricardo

; Fraxe, Therezinha de Jesus Pinto

; Lopes, Maria Teresa Gomes

Revista Árvore

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2023, Volume 47 elocation e4719

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT Astrocaryum aculeatum Mart. Moreover, Astrocaryum acaule Mart. are palm trees with ecological and extractive importance in the Amazon. These are hearty species that have been associated with archaeological sites and thrive in the presence of humans in certain areas. This work aimed to verify the effect of global climate change on the potential geographic distribution of A. acaule and A. aculeatum in the current period and future climate scenarios using ecological niche modeling in Brazilian phytogeographic domains. The modeling was based on 19 bioclimatic variables obtained from the Worldclim website and four algorithms (Climate space model, Envelope Score, Niche Mosaic, and Environmental Distance). Additionally, the Environmental Distance algorithm showed greater similarity regarding species distribution with potential occurrence in the five Brazilian domains (Amazon, Pantanal, Caatinga, Cerrado, and Atlantic Forest). The dispersion patterns were very similar between the two Astrocaryum palms though A. aculeatum was more sensitive to climatic variations. A. acaule may be more resilient to changes, as demonstrated by being able to recolonize in the southern portion of the Amazon in future scenarios in the year 2070. The modeling helped to delimit potential areas for A. aculeatum and A. acaule, indicating the need for the conservation of the species in more sensitive regions.

RESUMO Astrocaryum aculeatum Mart. e Astrocaryum acaule Mart. são palmeiras que apresentam importância ecológica e para o extrativismo na Amazônia. São espécies rústicas e que foram associadas a sítios arqueológicos e à presença de humanos em determinadas áreas. O objetivo deste trabalho foi verificar o efeito das mudanças climáticas globais na distribuição geográfica potencial de A. acaule e A. aculeatum, no período atual e em cenários climáticos futuros, utilizando a modelagem de nicho ecológico nos domínios fitogeográficos brasileiros. As modelagens foram baseadas em 19 variáveis bioclimáticas, obtidas no site do Worldclim, e quatro algoritmos (Climate space model, Envelope Score, Niche Mosaic e Enviromental Distance), dos quais o algoritmo Environmental Distance apresentou maior similaridade quanto à distribuição das espécies com ocorrência potencial nos cinco domínios brasileiros (Amazônia, Pantanal, Caatinga, Cerrado e Mata Atlântica). Os padrões de dispersão foram muito similares entre as duas palmeiras de Astrocaryum, porém A. aculeatum é mais sensível às variações climáticas. A. acaule tem potencial para ser mais resiliente às mudanças, podendo recolonizar a porção sul da Amazônia em cenários futuros, no ano de 2070. A modelagem auxiliou a delimitar as áreas potenciais de A. aculeatum e A. acaule, indicando a necessidade de conservação das espécies em regiões mais sensíveis.

https://doi.org/10.1590/1806-908820230000019

Contribution of public oral pathology services to the diagnosis of oral and oropharyngeal cancer in Brazil
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LOUREDO, Brendo Vinicius Rodrigues

; CURADO, Maria Paula

; PENAFORT, Paulo Victor Mendes

; DE ARRUDA, José Alcides Almeida

; ABREU, Lucas Guimarães

; MESQUITA, Ricardo Alves

; PINTO-JÚNIOR, Décio dos Santos

; ABRAHÃO, Aline Corrêa

; ANDRADE, Bruno Augusto Benevenuto de

; AGOSTINI, Michelle

; MORAES, Renata Mendonça

; ANBINDER, Ana Lia

; DOURADO, Pedro Henrique Silva

; SANTOS, Teresa Cristina Ribeiro Bartholomeu dos

; PIRES, Fábio Ramoa

; BORDIGNON, Natalia Cristina Trentin

; GONDAK, Rogério Oliveira

; DE OLIVEIRA, Marcia Gaiger

; CARRARD, Vinicius Coelho

; MARTINS, Manoela Domingues

; SOUSA-NETO, Sebastião Silvério

; ARANTES, Diego Antônio Costa

; MENDONÇA, Elismauro Francisco

; CIESLAK-SANCHES, Silvia Roberta

; ANTUNES, Daniella Moraes

; AMARAL-SILVA, Gleyson Kleber do

; MANIERI, Patricia Rubia

; RAMALHO, Luciana Maria Pedreira

; DOS SANTOS, Jean Nunes

; LEONEL, Augusto César Leal da Silva

; PEREZ, Danyel Elias da Cruz

; VERHEUL, Hannah Carmem Carlos Ribeiro Silva

; BARROSO, Keila Martha Amorim

; RODRIGUES, Flávia Luiza Santos

; GONZAGA, Amanda Katarinny Goes

; FERNANDES, Romana Renery

; DE SOUZA, Lélia Batista

; SOUZA, Lucas Lacerda de

; PONTES, Flávia Sirotheau Corrêa

; PONTES, Hélder Antônio Rebelo

; SILVA, Caroline Alfaia

; CÂMARA, Jeconias

; LIBÓRIO-KIMURA, Tatiana Nayara

; SANTOS-SILVA, Alan Roger

; LOPES, Márcio Ajudarte

; ALMEIDA, Oslei Paes de

; ROMAÑACH, Mário José

; VARGAS, Pablo Agustin

Brazilian Oral Research

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2023, Volume 37 elocation e126

Abstract: En | Text: En | PDF: En

Abstract This study aimed to evaluate the contribution of oral and maxillofacial pathology laboratories (OMPLs) in Brazilian public universities to the diagnosis of lip, oral cavity, and oropharyngeal squamous cell carcinoma (SCC). A cross-sectional study was performed using biopsy records from a consortium of sixteen public OMPLs from all regions of Brazil (North, Northeast, Central-West, Southeast, and South). Clinical and demographic data of patients diagnosed with lip, oral cavity, and oropharyngeal SCC between 2010 and 2019 were collected from the patients’ histopathological records. Of the 120,010 oral and maxillofacial biopsies (2010-2019), 6.9% (8,321 cases) were diagnosed as lip (0.8%, 951 cases), oral cavity (4.9%, 5,971 cases), and oropharyngeal (1.2%, 1,399 cases) SCCs. Most cases were from Brazil’s Southeast (64.5%), where six of the OMPLs analyzed are located. The predominant profile of patients with lip and oral cavity SCC was Caucasian men, with a mean age over 60 years, low schooling level, and a previous history of heavy tobacco consumption. In the oropharyngeal group, the majority were non-Caucasian men, with a mean age under 60 years, had a low education level, and were former/current tobacco and alcohol users. According to data from the Brazilian National Cancer Institute, approximately 9.9% of the total lip, oral cavity, and oropharyngeal SCCs reported over the last decade in Brazil may have been diagnosed at the OMPLs included in the current study. Therefore, this data confirms the contribution of public OMPLs with respect to the important diagnostic support they provide to the oral healthcare services extended by the Brazilian Public Health System.

https://doi.org/10.1590/1807-3107bor-2023.vol37.0126

Future projections and ecological modeling for the distribution of non-conventional food plants
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Borges, Carla Karoline Gomes Dutra

; Tomaz, Jennifer Souza

; Bezerra, Caroline de Souza

; Wrege, Marcos Silveira

; Lopes, Maria Teresa Gomes

Pesquisa Agropecuária Tropical

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2023, Volume 53 elocation e76279

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT The importance of non-conventional food plants has been evidenced due to their great potential for phenotypic plasticity, resilience and resistance to permanence in inhospitable places. This study aimed to evaluate the natural distribution of two of these species (Eryngium foetidum and Fridericia chica) in the present period (2009-2019) and the projection for two future climate scenarios (RCP 4.5 - “less pessimistic” and RCP 8.5 - “more pessimistic”) in two-time intervals (2020-2050 and 2051-2070), in the six Brazilian phytogeographic domains. Nineteen bioclimatic variables obtained from the WorldClim database and four algorithm models were tested: Climate Space Model, Envelope Score, Niche Mosaic and Environmental Distance. The Environmental Distance algorithm presented the best discrimination of the models adjusted for the two species. From the projections, it is possible to perceive that the species are severely affected in the phytogeographic domains of the Amazon, Pantanal and Pampa, becoming practically extinct in the RCP 8.5 scenario, for the period of 2051-2070.

RESUMO A importância de plantas alimentícias não convencionais tem sido evidenciada devido ao seu grande potencial de plasticidade fenotípica, resiliência e resistência à permanência em lugares inóspitos. Objetivou-se estudar a distribuição natural de duas espécies dessas plantas (Eryngium foetidum e Fridericia chica) no período presente (2009-2019) e a sua projeção para dois cenários climáticos futuros (RCP 4.5 - “menos pessimista” e RCP 8.5 - “mais pessimista”) em dois intervalos de tempo (2020-2050 e 2051-2070), nos seis domínios fitogeográficos brasileiros. Foram utilizadas 19 variáveis bioclimáticas obtidas da base de dados do WorldClim e quatro modelos de algoritmos foram testados: Climate Space Model, Envelope Score, Niche Mosaic e Environmental Distance. O algoritmo Environmental Distance apresentou a melhor discriminação dos modelos ajustados para as duas espécies. A partir das projeções, é possível perceber que as espécies são severamente afetadas nos domínios fitogeográficos da Amazônia, Pantanal e Pampa, tornando-se praticamente extintas no cenário RCP 8.5 para o período de 2051-2070.

https://doi.org/10.1590/1983-40632023v5376279

Using of relatedness and heritability in a Eucalyptus benthamii trial for conservation and breeding
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Souza, Bruno Marchetti de

; Abreu, Lucas Moura de

; Pappas, Marilia de Castro Rodrigues

; Azevedo, Vânia

; Santos, Paulo Eduardo Telles dos

; Sousa, Valderes Aparecida de

; Santos, Rodrigo Furtado dos

; Lopes, Maria Teresa Gomes

; Aguiar, Ananda Virginia

Crop Breeding and Applied Biotechnology

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2023, Volume 23 N. 4 elocation e46452348

Abstract: En | Text: En | PDF: En

Abstract We evaluated the genetic diversity, coancestry and heritability of an E. benthamii trial. The 115 individuals were genotyped (13 SSR) and had their height and diameter at breast height (dbh) measured. Heritability was estimated using the RR-BLUP and the pairwise kinship coefficient method. An average of nine alleles per locus was observed. The expected heterozygosity (0.655) was similar to the observed heterozygosity, with the estimated inbreeding (0.02) being low. The group coancestry (0.051) demonstrates that the trees are related to some degree. The trees were clustered in five groups using the Evanno’s method. The average kinship within each group ranges from 0.042 to 0.082. The heritability estimated by RR-BLUP was low. The heritability estimated using the kinship coefficients is moderate, reaching estimated genetic gains of 14% for dbh. After knowing how genetic groups are distributed within the population, strategies for collecting, conserving, and using these germplasm resources can be performed.

https://doi.org/10.1590/1984-70332023v23n4a43

Could ultrasound and muscle elastography be associated with clinical assessment, laboratory and nailfold capillaroscopy in juvenile dermatomyositis patients?
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de Andrade, Renata Lopes Francisco

; Mendonça, José Alexandre

; Piotto, Daniela Petry

; Guimarães, Julio Brandão

; Terreri, Maria Teresa

Advances in Rheumatology

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2023, Volume 63 elocation 48

Abstract: En | Text: En | PDF: En

Abstract Background Juvenile Dermatomyositis (JDM) is the most common idiopathic inflammatory myopathy in children. Imaging exams are useful for muscle assessment, with ultrasonography (US) being a promising tool in detecting disease activity and tissue damage. There are few studies about muscle elastography. Objectives Our aim was to associate clinical, laboratory, and nailfold capillaroscopy (NC) assessments with US in JDM patients; and to compare the findings of US and Strain Elastography (SE) from patients and healthy controls. Methods An analytic cross-sectional study was performed with JDM patients and healthy controls. Patients underwent clinical exam to access muscle strength and completed questionnaires about global assessment of the disease and functional capacity. Patients were submitted to NC and measurement of muscle enzymes. All subjects underwent US assessment, using gray scale, Power Doppler (PD), and SE. Results Twenty-two JDM patients and fourteen controls, aged between 5 and 21 years, matched for age and sex were assessed. In qualitative and semi-quantitative gray scale, we observed a higher frequency of alterations in patients (p < 0.001), while in PD, there was a higher frequency of positivity in patients’ deltoids and anterior tibialis (p < 0.001). Active disease was associated with an important change in the semi-quantitative gray scale in deltoids (p = 0.007), biceps brachii (p = 0.001) and quadriceps femoris (p = 0.005). The SE demonstrated a high negative predictive value of 87.2. Conclusion US was able, through gray scale, to differentiate JDM patients from controls, while PD achieved such differentiation only for deltoids and anterior tibialis. The semi-quantitative gray scale showed disease activity in proximal muscles. SE was not able to differentiate patients from controls.

https://doi.org/10.1186/s42358-023-00330-2

10.

Dermatose bolhosa IgA linear induzida pela vancomicina
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Guimarães, Maria José

; Lopes, Ana Gabriela

; Pereira, Teresa

Revista Portuguesa de Imunoalergologia

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dec 2022, Volume 30 N. 4 Pages 319 - 321

Abstract: Pt | Text: Pt | PDF: Pt

https://doi.org/10.32932/rpia.2022.12.096

11.

The prevalence and association of motor competence with weight status and bullying: a cross-cultural study
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Zequinão, Marcela Almeida

; Medeiros, Pâmella de

; Skrzypiec, Grace

; Lopes, Luis

; Trevisol, Maria Teresa Ceron

; Pereira, Beatriz

Motricidade

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jun 2022, Volume 18 N. 1 Pages 1 - 10

Abstract: En | Text: En | PDF: En

Abstract The purpose of this study was to compare the prevalence of motor competence among children and adolescents from two metropolitan cities, one in Portugal and one in Brazil, and analyzed the association between motor competence and weight status and bullying roles. A Cross-sectional and cross-cultural study was applied. The sample comprised 785 children and adolescents aged 7-14. Motor competence was assessed using The Körperkoordinationtest Für Kinder (KTK) test, while participation in bullying was assessed using a sociometric test and the students’ Body Mass Index (BMI), which was calculated from height and weight and reported as kg/m2. Portuguese students had a higher prevalence of impairment/disturbance in motor coordination. Also, obese students and bullying victims had higher odds of having a motor competence below normal values in both countries. These findings provide evidence of a link between motor competence and sex and weight status of schoolchildren and suggest that motor competence is associated with bullying roles.

https://doi.org/10.6063/motricidade.19752

12.

Maxillary lateral incisor agenesis and microdontia: Minimally invasive symmetric and asymmetric esthetic rehabilitation
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Lopes-Rocha, Lígia

; Garcez, Joana

; Tiritan, Maria Elizabeth

; Silva, Lucas F.M. da

; Pinho, Teresa

Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilofacial

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mar 2022, Volume 63 N. 1 Pages 41 - 51

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo A agenesia dos incisivos laterais maxilares é uma condição que compromete significativamente a estética do sorriso. Neste artigo, mostramos como a combinação de tratamentos não invasivos e opções restauradoras podem melhorar os resultados clínicos após tratamento ortodôntico, em casos de agenesia simétrica e assimétrica dos incisivos laterais superiores e microdontia. A reabilitação dos três casos clínicos descritos foi realizada com restaurações em resina composta: os dois primeiros casos referem-se a agenesia de incisivos laterais (unilateral e bilateral) e o terceiro a microdontia. Após a apresentação dos resultados clínicos, este artigo resume como o branqueamento, coronoplastia e restaurações com resina podem melhorar a estética e a função após o tratamento ortodôntico. Os casos revelam que a integração de abordagens ortodônticas e restauradoras cuidadosamente planeadas e metodicamente executadas constituem uma solução minimamente invasiva permitindo alcançar resultados estéticos previsíveis.

Abstract Maxillary lateral incisor agenesis is a condition that significantly compromises smile esthetics, which is particularly worrying in young patients. This article shows how the combination of non-invasive treatments and current restorative options may improve clinical outcomes following orthodontic treatment for symmetric and asymmetric maxillary lateral incisor agenesis and microdontia. Teeth were treated with conservative resin restorations in three separate cases: two of congenitally missing maxillary lateral incisors (i.e., unilateral and bilateral) and one of microdontia. After presenting the clinical results, this article summarizes how bleaching, enameloplasty, and bonding with composite resin can enhance esthetics and functions following orthodontic space closure. The cases reveal that carefully planned, methodically executed orthodontic and restorative approaches can achieve predictable, esthetic outcomes that will improve the patient’s self-esteem with a minimally invasive solution.

https://doi.org/10.24873/j.rpemd.2022.01.857 14 downloads

13.

The effects of pharmacist interventions on health outcomes in patients with advanced prostate cancer in Brazil
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Aguiar, Patricia M

; Mori, Ana Luiza PM

; Lima, Maria GF de

; Rossi, Magali SPN

; Nicoletti, Maria Aparecida

; Martins, Karina OF

; Lopes, Ana Lúcia M

; Coan, Teresa Cristina M

; Fugita, Oscar Eduardo H

; Storpirtis, Sílvia

Brazilian Journal of Pharmaceutical Sciences

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2022, Volume 58 elocation e19273

Abstract: En | Text: En | PDF: En

Abstract This study examined the effects of pharmacist interventions for patients with advanced prostate cancer. A pre-post study was conducted between October 2014 and August 2017 in a community pharmacy in Brazil for outpatients with advanced prostate cancer, aged ≥ 18 years, using cyproterone acetate and/or goserelin. The patients had face-to-face meetings with a pharmacist who dispensed antiandrogenic drugs and performed interventions aimed at solving and/or preventing drug-therapy problems. Primary outcomes regarding prostate-specific antigen (PSA) and testosterone levels were compared at 0, 6, and 12 months, whereas secondary outcomes-medication adherence and quality of life-were compared at baseline and at the 12-month follow-up. Medication adherence was assessed using the Morisky-Green test, and quality of life was measured by the Medical Outcomes Study 36-item Short Form (SF-36) and the Functional Assessment of Cancer Therapy-Prostate (FACT-P). The analysis included 20 patients; 311 drug-therapy problems were identified and most of them were related to adverse reactions (78.5%). The most common adverse reactions were reduced libido, erectile dysfunction, hyperglycemia, fatigue, and gynecomastia. Testosterone levels significantly decreased at 6 months, and PSA levels at 6 and 12 months. No significant changes in adherence were noted at the end of the study. A significant increase in the “pain” domain and an improvement trend in the “physical aspects” and “vitality” domains were observed based on the SF-36 instrument. The findings show that pharmacist interventions were able to improve PSA and testosterone levels, and some domains of quality of life of patients.

https://doi.org/10.1590/s2175-97902021000219273

14.

Paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS): a Brazilian cohort
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Cavalcanti, André

; Islabão, Aline

; Magalhães, Cristina

; Veloso, Sarah

; Lopes, Marlon

; Prado, Rogério do

; Aquilante, Bruna

; Terrazas, Ana Maria

; Rezende, Maria Fernanda

; Clemente, Gleice

; Terreri, Maria Teresa

Advances in Rheumatology

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2022, Volume 62 elocation 6

Abstract: En | Text: En | PDF: En

Abstract Background: Paediatric inflammatory multisystem syndrome (PIMS) associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been described since mid-April 2020 with the first reports coming from Europe. Our objective was to describe the characteristics of patients among the Brazilian population. Methods: A multicenter retrospective study was conducted with the participation of five pediatric rheumatology centers in Brazil during the period from March to November 2020. Children and adolescents with PIMS temporally associated with SARS-CoV-2 (TS) who met the definition criteria for the disease according to the Royal College of Paediatrics and Child Health were included. Demographic, clinical, laboratory, therapeutic characteristics and molecular and serological diagnosis of SARS-CoV-2 infection were described. Results: Fifty-seven children and adolescents with PIMS-TS were evaluated, 54% female, with a median age of 8 (3–11) years. Most (86%) were previously healthy, with asthma being the main comorbidity, present in 10% of the patients. Fever was the main manifestation, present in all patients, followed by mucocutaneous and gastrointestinal features, present in 89% and 81% of the patients, respectively. Myocarditis occurred in 21% of the patients and in 68% of them required intensive care. The Kawasaki disease phenotype occurred in most patients (77%). All patients had elevated inflammatory markers, with elevated CRP being the most found (98%). Anemia and lymphopenia were present in 79% and 72%, respectively. Laboratory evidence of SARS-CoV-2 was found in 77% of the patients, with 39% positive RT-PCR and 84% positive serology for SARS-CoV-2. An immunomodulatory treatment was performed in 91% of the patients, with 67% receiving intravenous immunoglobulin (IVIG) associated with glucocorticoid, 21% receiving IVIG, and 3.5% receiving glucocorticoid. The median length of hospitalization was 10 days. Conclusions: This study showed a high morbidity of PIMS-TS in Brazilian children, with a prolonged length of hospitalization and a high rate of admission to pediatric intensive care unit. Multicenter prospective studies are needed to assess the morbidity of the disease in the medium and long term.

https://doi.org/10.1186/s42358-022-00237-4

15.

Prediction of the natural distribution, habitat and conservation of Stryphnodendron pulcherrimum (Willd.) Hochr. in response to global climate change
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Tomaz, Jennifer Souza

; Bezerra, Caroline de Souza

; Aguiar, Ananda Virginia de

; Wrege, Marcos Silveira

; Lopes, Maria Teresa Gomes

Pesquisa Agropecuária Tropical

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2022, Volume 52 elocation e72422

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Stryphnodendron pulcherrimum é uma espécie medicinal usada entre as comunidades tradicionais da Amazônia devido à sua atividade bactericida e propriedades anti-infamatórias. Apesar de estar adaptada a ambientes rústicos, não há informações de como as mudanças climáticas poderão afetar a ocorrência da espécie. Objetivou-se avaliar a distribuição natural de S. pulcherrimum no período atual e como sua distribuição geográfica potencial poderá ser afetada diante de cenários de mudanças climáticas futuras nos domínios ftogeográficos brasileiros. Foram utilizadas 19 variáveis bioclimáticas a partir da base de dados do WorldClim. Quatro modelos de algoritmo (Climate Space Model, Envelope Score, Niche Mosaic e Enviromental Distance - presente) e um software (Open Modeller - futuro) foram utilizados para verificar a ocorrência potencial de S. pulcherrimum em cinco domínios (Amazônia, Cerrado, Caatinga, Mata Atlântica e Pantanal) e três períodos (2009-2019 - presente; 2020-2050 e 2051-2070 - futuro). Houve perdas de áreas favoráveis à ocorrência de S. pulcherrimum na Amazônia, Cerrado e Pantanal, e as mudanças climáticas globais poderão afetar sua distribuição natural especialmente na Mata Atlântica e Amazônia, sendo que, na Amazônia, a espécie pode estar totalmente extinta, no cenário mais pessimista, até 2070.

ABSTRACT Stryphnodendron pulcherrimum is a species used medicinally among traditional Amazonian communities for its bactericidal activity and anti-inflammatory properties. Despite being adapted to rustic environments, there is no information regarding how climate change might affect the species occurrence. The present study aimed to evaluate the natural distribution of S. pulcherrimum in the current period and how its potential geographic distribution may be affected in response to future climate change scenarios in Brazilian phytogeographic domains. A total of 19 bioclimatic variables were used from the WorldClim database. Four algorithm models (Climate Space Model, Envelope Score, Niche Mosaic and Environmental Distance - present) and one software (Open Modeller - future) were used to verify the potential occurrence of S. pulcherrimum in five Brazilian domains (Amazon, Cerrado, Caatinga, Atlantic Forest and Pantanal) and three intervals (2009-2019 - present; 2020-2050 and 2051-2070 - future). There were losses of areas favorable to the occurrence of S. pulcherrimum in the Amazon, Cerrado and Pantanal, and global climate change may affect its natural distribution especially in the Atlantic Forest and Amazon. In the Amazon, the species may be totally extinct, in the worst scenario, by 2070.

https://doi.org/10.1590/1983-40632022v5272422

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