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au:LOURENCO, A. P.
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1.
Major discrepancy between clinical diagnosis of death and anatomopathological findings in adolescents with chronic diseases during 18-years
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Ribeiro, Maira P.
; Duarte Neto, Amaro N.
; Dolhnikoff, Marisa
; Lindoso, Livia
; Lourenco, Benito
; Marques, Heloisa H.
; Pereira, Maria F.B.
; Cristofani, Lilian M.
; Odone Filho, Vicente
; Campos, Lucia M.A.
; Sallum, Adriana M.E.
; Carneiro-Sampaio, Magda
; Delgado, Artur F.
; Carvalho, Werther B.
; Mauad, Thais
; Silva, Clovis A.
.
Abstract Objectives: To evaluate the inconsistency between clinical diagnosis of death and autopsy findings in adolescents with chronic diseases. Methods: A cross-sectional study including a sample of adolescents’ autopsies who died in a pediatric and adolescent tertiary hospital over 18 consecutive years. During this period, there were n = 2912 deaths, and n = 581/2912(20%) occurred in adolescents. Of these, n = 85/581(15%) underwent autopsies and were analyzed. Further results were divided into two groups: Goldman classes I or II (high disagreement between main clinical diagnosis of death and anatomopathological findings, n = 26) and Goldman classes III, IV or V (low or no disagreement between these two parameters, n = 59). Results: Median age at death (13.5 [10‒19] vs. 13 [10‒19] years, p = 0.495) and disease duration (22 [0‒164] vs. 20 [0‒200] months, p = 0.931), and frequencies for males (58% vs. 44%, p = 0.247) were similar between class I/II vs. class III/IV/V. The frequency of pneumonia (73% vs. 48%, p = 0.029), pulmonary abscess (12% vs. 0%, p = 0.026), as well as isolation of yeast (27% vs. 5%, p = 0.008), and virus (15% vs. 2%, p = 0.029) identified in the autopsy, were significantly higher in adolescents with Goldman class I/II compared to those with Goldman class III/IV/V. In contrast, cerebral edema was significantly lower in adolescents of the first group (4% vs. 25%, p = 0.018). Conclusion: This study showed that 30% of the adolescents with chronic diseases had major discrepancies between clinical diagnosis of death and autopsy findings. Pneumonia, pulmonary abscess, as well as isolation of yeast and virus were more frequently identified at autopsy findings in the groups with major discrepancies.
2.
Post-surgical follow-up of primary hyperparathyroidism associated with multiple endocrine neoplasia type 1
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Coutinho, Flavia L.
; Lourenco Jr., Delmar M.
; Toledo, Rodrigo A.
; Montenegro, Fabio L. M.
; Toledo, Sergio P. A.
.
The bone mineral density increments in patients with sporadic primary hyperparathyroidism after parathyroidectomy have been studied by several investigators, but few have investigated this topic in primary hyperparathyroidism associated with multiple endocrine neoplasia type 1. Further, as far as we know, only two studies have consistently evaluated bone mineral density values after parathyroidectomy in cases of primary hyperparathyroidism associated with multiple endocrine neoplasia type 1. Here we revised the impact of parathyroidectomy (particularly total parathyroidectomy followed by autologous parathyroid implant into the forearm) on bone mineral density values in patients with primary hyperparathyroidism associated with multiple endocrine neoplasia type 1. Significant increases in bone mineral density in the lumbar spine and femoral neck values were found, although no short-term (15 months) improvement in bone mineral density at the proximal third of the distal radius was observed. Additionally, short-term and medium-term calcium and parathyroid hormone values after parathyroidectomy in patients with primary hyperparathyroidism associated with multiple endocrine neoplasia type 1 are discussed. In most cases, this surgical approach was able to restore normal calcium/parathyroid hormone levels and ultimately lead to discontinuation of calcium and calcitriol supplementation.
https://doi.org/10.6061/clinics/2012(Sup01)28
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3.
A low-mass neutron flux monitor for the n _TOF facility at CERN
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Mastinu, P. F.
; Abbondanno, U.
; Aerts, G.
; Alvarez, H.
; Andriamonje, S.
; Angelopoulos, A.
; Assimakopoulos, P.
; Bacri, C.O.
; Badurek, G.
; Baumann, P.
; Becvár, F.
; Beer, H.
; Benlliure, J.
; Berthier, B.
; Berthomieux, E.
; Boffi, S.
; Borcea, C.
; Boscolo-Marchi, E.
; Bustreo, N.
; Calviño, P.
; Cano-Ott, D.
; Capote, R.
; Carlson, P.
; Cennini, P.
; Chepel, V.
; Chiaveri, E.
; Coceva, C.
; Colonna, N.
; Cortes, G.
; Cortina, D.
; Couture, A.
; Cox, J.
; Dababneh, S.
; Dahlfors, M.
; David, S.
; Dolfini, R.
; Domingo-Pardo, C.
; Duran, I.
; Eleftheriadis, C.
; Embid-Segura, M.
; Ferrant, L.
; Ferrari, A.
; Ferreira-Lourenco, L.
; Ferreira-Marques, R.
; Frais-Koelbl, H.
; Furman, W.I.
; Giomataris, Y.
; Goncalves, I.F.
; Gonzalez-Romero, E.
; Goverdovski, A.
; Gramegna, F.
; Griesmayer, E.
; Gunsing, F.
; Haight, R.
; Heil, M.
; Herrera-Martinez, A.
; Ioannides, K.G.
; Janeva, N.
; Jericha, E.
; Käppeler, F.
; Kadi, Y.
; Karamanis, D.
; Kelic, A.
; Ketlerov, V.
; Kitis, G.
; Koehler, P.E.
; Konovalov, V.
; Kossionides, E.
; Lacoste, V.
; Leeb, H.
; Lindote, A.
; Lopes, M.I.
; Loriggiola, M.
; Lozano, M.
; Lukic, S.
; Markov, S.
; Marigo, S.
; Marrone, S.
; Martinez-Val, J.
; Mengoni, A.
; Milazzo, P.M.
; Minguez, E.
; Molina-Coballes, A.
; Moreau, C.
; Neves, F.
; Oberhummer, H.
; O'Brien, S.
; Pancin, J.
; Papaevangelou, T.
; Paradela, C.
; Pavlik, A.
; Pavlopoulos, P.
; Perez-Parra, A.
; Perlado, J.M.
; Perrot, L.
; Peskov, V.
; Plag, R.
; Plompen, A.
; Plukis, A.
; Poch, A.
; Policarpo, A.
; Pretel, C.
; Quesada, J.M.
; Radici, M.
; Raman, S.
; Rapp, W.
; Rauscher, T.
; Reifarth, R.
; Rejmund, F.
; Rosetti, M.
; Rubbia, C.
; Rudolf, G.
; Rullhusen, P.
; Salgado, J.
; Savvidis, E.
; Soares, J.C.
; Stephan, C.
; Tagliente, G.
; Tain, J.L.
; Tapia, C.
; Tassan-Got, L.
; Tavora, L.M.N.
; Terlizzi, R.
; Terrani, M.
; Tsangas, N.
; Vannini, G.
; Vaz, P.
; Ventura, A.
; Villamarin-Fernandez, D.
; Vincente-Vincente, M.
; Vlachoudis, V.
; Vlastou, R.
; Voss, F.
; Wendler, H.
; Wiescher, M.
; Wisshak, K.
; Zanini, L.
.
A small-mass system has been developed for monitoring the flux of neutrons with energy up to 1 MeV at the new time-of-flight facility at CERN, n_TOF. The monitor is based on a thin Mylar foil with a 6Li deposit, placed in the neutron beam, and an array of Silicon detectors, placed outside the beam, for detecting the products of the 6Li(n, alpha)³H reaction. The small amount of material on the beam ensures a minimal perturbation of the flux and minimizes the background related to scattered neutrons. Moreover, a further reduction of the gamma-ray background has been obtained by constructing the scattering chamber hosting the device in carbon fibre. A detailed description of the flux monitor is here presented, together with the characteristics of the device, in terms of efficiency, resolution and induced background. The use of the monitor in the measurement of neutron capture cross-sections at n_TOF is discussed
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