ABSTRACT Children have an increased likelihood of becoming carriers of the chronic hepatitis B virus. A total of 1,381 children and adolescents were assessed in five municipalities of Maranhao State, Brazil, for detection of anti-HBc, HBsAg and anti-HBs serologic markers and sociodemographic and behavioral features. Among those who were HBsAg negative and anti-HBc negative, the proportion of anti-HBs positives was calculated after the individuals had completed the vaccination schedule. The robust variance of the Poisson’s regression model was used in order to have adjusted tables and calculate the prevalence ratio. Multivariate analysis was performed to identify the factors associated with the prevalence of anti-HBc with or without HBsAg and the vaccine response. It was observed that 163 children were anti-HBc positive and nine individuals were HBsAg positive. The factors associated with the infection were: municipality of residence (residing in Morros municipality or Humberto de Campos municipality), residence in a rural area, aged between 13 and 15 years old, and illicit drug use. The percentage of individuals who were anti-HBc negative and received all three doses of the vaccine was 48.5%. Among these, only 276 (38.9%) had antibodies at protective concentrations. In an adjusted analysis, Morros municipality presented an increased positivity of vaccine response (p < 0.001), and the age ranging between 6 and 10 years old presented a reduced frequency of response. This study reveals a high prevalence of current and past HBV infection within the targeted age group which, in addition to the low vaccination coverage and serological responses, raises concerns about the management of prevention measures, especially the quality of vaccination in these locations.

Resumo Diante de crise e estagnação econômica, o governo brasileiro, no âmbito fiscal, tem se caracterizado pela adoção de políticas tributárias desonerativas. Nesse cenário, o presente trabalho visou investigar o comportamento de algumas dimensões da atividade industrial, tendo como mote central o efeito das desonerações do Imposto Sobre Produtos Industrializados no crescimento econômico dos municípios brasileiros. A estratégia empírica consistiu no uso de modelos estatísticos em dados em painel e regressão quantílica, tomando como referência o período entre os anos de 2007 e 2017. Dentre os principais resultados destacam-se o fato de que mesmo com o comportamento positivo da atividade industrial, principalmente entre os anos de 2009 e 2013, as desonerações não contribuíram para o crescimento econômico dos municípios brasileiros.

ABSTRACT Faced with economic crisis and stagnation, the Brazilian government, in the fiscal realm, has been characterized by the adoption of exemption tax policies. In this scenario, the present study aimed to investigate the behavior of some dimensions of industrial activity, having as its central focus the effect that the Tax on Industrialized Products exemptions has on the economic growth of Brazilian municipalities. The empirical strategy employed used statistical models in panel data and quantile regression, taking the period between 2007 and 2017. The main results indicated that, even with the positive behavior of industrial activity, especially between 2009 and 2013, the exemptions did not contribute to the economic growth of Brazilian municipalities.

A literatura endossa o crescente papel central de coordenação do governo federal nas políticas de saúde. Porém, há poucos estudos sobre o papel dos entes subnacionais, em especial, dos estados. Assim, este artigo analisou o arranjo institucional de implementação do Projeto Mais Médicos para o Brasil (PMMB) no estado de Minas Gerais. O trabalho foi realizado com base em análise documental de 31 atas de reuniões da Comissão de Coordenação Estadual e oito entrevistas com atores-chave responsáveis por sua implementação. Os resultados evidenciaram a (i) centralidade decisória do projeto no âmbito federal, a (ii) pouca clareza do papel do governo estadual no arranjo de implementação, a (iii) crise orçamentária do governo mineiro e a (iv) instabilidade política, que resultaram em (v) trocas de governo estadual e federal. Tais fatores, em conjunto, impactaram na capacidade de implementação do projeto em Minas Gerais.

The literature evidences the growing central coordinating role played by the federal government in health policy. However, there is little research on the role of subnational entities, especially state governments. This article analyzes the institutional arrangement for the implementation of the More Doctors for Brazil Project in the state of Minas Gerais. The study drew on data from a documentary analysis of 31 minutes of meetings of the State Coordinating Commission and eight interviews with key actors responsible for the implementation of the project. The results highlight: (i) Centralized Project decision-making at federal level; (ii) Lack of clarity with regard to the role of the state government in the implementation arrangement; (iii) A state government funding crisis; and (iv) Political instability, which result in (v) Changes in the state and federal government. These combined factors had a negative impact on project implementation capacity in Minas Gerais.

La literatura endosa el creciente papel central de coordinación del gobierno federal en las políticas de salud. No obstante, hay pocos estudios sobre el papel de los entes subnacionales, en especial de los estados. Por lo tanto, este artículo analizó la organización institucional de implementación del proyecto Más Médicos para Brasil (PMMB) en el estado de Minas Gerais. El trabajo se realizó con base en el análisis documental de 31 actas de reuniones de la Comisión de Coordinación Estatal y ocho entrevistas con actores-clave responsables por su implementación. Los resultados pusieron en evidencia: (i) la centralidad de decisión del Proyecto en el ámbito federal; (ii) la poca claridad del papel del gobierno estatal en la organización de la implementación; (iii) la crisis presupuestaria del gobierno del Estado de Minas Gerais y (iv) la inestabilidad política, lo que resultó en (v) cambios de gobierno estatal y federal. Tales factores, en conjunto, tuvieron impacto sobre la capacidad de implementación del Proyecto en Minas Gerais.

The literature evidences the growing central coordinating role played by the federal government in health policy. However, there is little research on the role of subnational entities, especially state governments. This article analyzes the institutional arrangement for the implementation of the More Doctors for Brazil Project in the state of Minas Gerais. The study drew on data from a documentary analysis of 31 minutes of meetings of the State Coordinating Commission and eight interviews with key actors responsible for the implementation of the project. The results highlight: (i) Centralized Project decision-making at federal level; (ii) Lack of clarity with regard to the role of the state government in the implementation arrangement; (iii) A state government funding crisis; and (iv) Political instability, which result in (v) Changes in the state and federal government. These combined factors had a negative impact on project implementation capacity in Minas Gerais.

La literatura endosa el creciente papel central de coordinación del gobierno federal en las políticas de salud. No obstante, hay pocos estudios sobre el papel de los entes subnacionales, en especial de los estados. Por lo tanto, este artículo analizó la organización institucional de implementación del proyecto Más Médicos para Brasil (PMMB) en el estado de Minas Gerais. El trabajo se realizó con base en el análisis documental de 31 actas de reuniones de la Comisión de Coordinación Estatal y ocho entrevistas con actores-clave responsables por su implementación. Los resultados pusieron en evidencia: (i) la centralidad de decisión del Proyecto en el ámbito federal; (ii) la poca claridad del papel del gobierno estatal en la organización de la implementación; (iii) la crisis presupuestaria del gobierno del Estado de Minas Gerais y (iv) la inestabilidad política, lo que resultó en (v) cambios de gobierno estatal y federal. Tales factores, en conjunto, tuvieron impacto sobre la capacidad de implementación del Proyecto en Minas Gerais.

A literatura endossa o crescente papel central de coordenação do governo federal nas políticas de saúde. Porém, há poucos estudos sobre o papel dos entes subnacionais, em especial, dos estados. Assim, este artigo analisou o arranjo institucional de implementação do Projeto Mais Médicos para o Brasil (PMMB) no estado de Minas Gerais. O trabalho foi realizado com base em análise documental de 31 atas de reuniões da Comissão de Coordenação Estadual e oito entrevistas com atores-chave responsáveis por sua implementação. Os resultados evidenciaram a (i) centralidade decisória do projeto no âmbito federal, a (ii) pouca clareza do papel do governo estadual no arranjo de implementação, a (iii) crise orçamentária do governo mineiro e a (iv) instabilidade política, que resultaram em (v) trocas de governo estadual e federal. Tais fatores, em conjunto, impactaram na capacidade de implementação do projeto em Minas Gerais.

RESUMO O artigo investiga a relação entre a situação fundiária e a condição da ocupação do lote, o uso do solo e o estado de conservação dos imóveis em áreas tombadas, a partir do estudo de um bairro inserido no Centro Histórico de Belém (CHB). Baseado em pesquisas bibliográficas e documentais e usando geoprocessamento, traça o histórico e o perfil da situação fundiária atual dos imóveis, quantifica e mapeia as características e os regimes de propriedade encontrados. Além disso, discute o papel do conflito entre municipalidade e União em torno dos terrenos de marinha e acrescidos na gestão do patrimônio fundiário e histórico. Constata que: (i) 55,85% da área e 44,79% dos imóveis carecem de informação sobre a situação fundiária; (ii) dos imóveis com informações, o traspasse é o tipo de alienação predominante (41,5%); (iii) os imóveis traspassados e aforados, apresentam melhor conservação do que os alienados por resgate; (iv) o grau de conservação dos imóveis é preocupante ao somar os percentuais de imóveis baldios, em ruínas, e com má e regular conservação (59,5%). Conclui-se que esse quadro ainda pode ser revertido, destacando o papel da questão fundiária para a conservação urbana em sítios históricos tombados como o CHB.

ABSTRACT The article investigates the relationship between the land situation and the condition of occupation of the lot, land use and the state of conservation of properties in listed areas, based on the study of a neighborhood located in the Historic Center of Belém (CHB). Based on bibliographic and documentary research and using geoprocessing, it traces the history and profile of the current land tenure situation of the properties, quantifies and maps the characteristics and property regimes found. In addition, it discusses the role of the conflict between the municipality and the Union over marine lands and added to the management of land and historical heritage. It finds that: (i) 55.85% of the area and 44.79% of the properties lack information on the land tenure situation; (ii) of properties with information, transfer is the predominant type of sale (41.5%); (iii) properties transferred and transferred are better preserved than those sold by redemption; (iv) the degree of conservation of the properties is of concern when adding up the percentages of vacant properties, in ruins, and with poor and regular maintenance (59.5%). It concludes that this situation can still be reversed, highlighting the role of the land issue for urban conservation in listed historic sites such as the CHB.

Abstract Background and aims: minimizing nutritional depletions after a Roux-en-Y gastric bypass (RYGB) may improve clinical results in the treatment of obesity. We evaluated nutritional aspects of obese women undergoing RYGB at a reference university hospital with a department specialized in bariatric surgery. Method: based on the Dietary Reference Intakes developed by the Food and Nutrition Council, Institute of Medicine, and the guidelines issued by the American Society for Metabolic and Bariatric Surgery, we assessed the quantitative and qualitative adequacy of nutritional intake, supplementation, and biochemical monitoring of 20 women both before and 3 and 12 months after a RYGB. Data on nutritional intake was obtained by applying different food surveys, quantitatively interpreted by the Virtual Nutri Plus® software and using reference nutritional databases. Results: nutritional intake deficits were already found before the RYGB (p ≤ 0.05). These worsened postoperatively (p ≤ 0.05), a period also marked by a qualitatively poor diet. The nutritional supplementation prescribed did not fully achieve the reference recommendations, and was poorly complied with by patients. Furthermore, nutritional monitoring was not carried out in all patients, recommended biochemical markers were not screened, and vitamin D depletions occurred. Conclusion: our data suggest that institutions specialized in bariatric patient care may not be adequately adhering to well known guidelines, or applying efficient strategies to improve compliance.

Resumen Antecedentes y objetivos: minimizar el deterioro nutricional después del baipás gástrico en Y de Roux (BGYR) puede mejorar los resultados clínicos en el tratamiento de la obesidad. Se evaluaron aspectos nutricionales de mujeres obesas sometidas a BGYR en un hospital universitario de referencia con servicio especializado de cirugía bariátrica. Método: con base en la Ingesta Dietética de Referencia desarrollada por el Consejo de Alimentos y Nutrición del Instituto de Medicina, y las directrices de la Sociedad Estadounidense de Cirugía Bariátrica y Metabólica, evaluamos la adecuación cuantitativa y cualitativa de la ingesta nutricional, la suplementación y el seguimiento bioquímico de 20 mujeres tanto antes como 3 y 12 meses después de un BGYR. Los datos de la ingesta nutricional se obtuvieron mediante la aplicación de diferentes encuestas alimentarias, interpretadas cuantitativamente por el software Virtual Nutri Plus® y utilizando bases de datos nutricionales de referencia. Resultados: se encontraron déficits de ingesta nutricional antes del BGYR (p < 0,05). Estos empeoraron en el postoperatorio (p < 0,05), período también marcado por una mala alimentación cualitativa. La suplementación nutricional prescrita no cumplió plenamente con las recomendaciones de referencia y no fue bien cumplida por los pacientes. Además, la monitorización nutricional no se aplicó en todos los pacientes y no se examinaron todos los marcadores bioquímicos recomendados, hallándose depleciones de vitamina D. Conclusión: nuestros datos sugieren que las instituciones especializadas en la atención de pacientes bariátricos podrían no estar siguiendo adecuadamente las pautas recomendadas, ni aplicando estrategias eficientes para mejorar su cumplimiento.

RESUMO Analisou-se o processo alocativo de médicos pelo Programa Mais Médicos (PMM), procurando identificar se o objetivo de priorizar os municípios com maiores vulnerabilidades em saúde, a fim de reduzir a escassez de médicos no território nacional, foi cumprido. Para tanto, a partir de aspectos epidemiológicos e socioeconômicos foi construído o Índice de Vulnerabilidade e Condições em Saúde (IVCS) antes e após a implementação do PMM, nos períodos de 2012 e 2015, para mais de 97% de todos os 5.570 municípios brasileiros. Em seguida, analisou-se o processo alocativo de médicos considerando o índice proposto. Os resultados indicaram incremento de médicos no período em estudo (2013 a 2017) em territórios anteriormente desassistidos ou com dificuldades de fixação de médicos. Houve ampliação na cobertura e alocação de médicos em municípios em situação de severa e alta vulnerabilidade em saúde, nos municípios de pequeno porte e situados nas regiões norte e nordeste do país. Entretanto, evidenciou-se iniquidades alocativas e redução da oferta regular de médicos nos municípios em condição severa de vulnerabilidade e naqueles de pequeno porte.

ABSTRACT The medical allocation process was analyzed by the More Doctors Program (PMM), seeking to identify whether the objective of prioritizing the municipalities with the greatest vulnerabilities in health, in order to reduce the shortage of doctors in the national territory, was accomplished. Therefore, from epidemiological and socioeconomic aspects, the Vulnerability Index and Health Conditions (IVCS) was built before and after the implementation of the PMM, in the periods of 2012 and 2015, for more than 97% of all 5,570 Brazilian municipalities. Then, the allocative process of physicians was analyzed considering the proposed index. The results indicated an increase of doctors in the analyzed period (2013 to 2017) in territories previously unassisted or with difficulties in establishing doctors. There was an increase in the coverage and allocation of doctors in municipalities in severe situations and high health vulnerability, in small municipalities located in the north and northeast of the country. However, there was evidence of inequalities allocated by the PMM and a reduction in the regular supply of doctors in severely vulnerable municipalities and in small ones.

RESUMEN El proceso de asignación médica fue analizado por el Programa Más Médicos (PMM), buscando identificar si se logró el objetivo de priorizar los municipios con mayores vulnerabilidades en salud, a fin de reducir la escasez de médicos en el territorio nacional. Por lo tanto, desde los aspectos epidemiológicos y socioeconómicos, el Índice de Vulnerabilidad y Condiciones de Salud (IVCS) se construyó antes y después de la implementación del PMM, en los períodos de 2012 y 2015, para más del 97% de los 5.570 municipios brasileños. Luego, se analizó el proceso de asignación de médicos considerando el índice propuesto. Los resultados indicaron un aumento de médicos en el período analizado (2013 a 2017) en territorios previamente sin asistencia o con dificultades para establecer médicos. Hubo un aumento en la cobertura y asignación de médicos en municipios en situaciones severas y alta vulnerabilidad a la salud, en municipios pequeños ubicados en el norte y noreste del país. Sin embargo, se evidenciaron desigualdades en la asignación de PMM y disminuyó la oferta regular de médicos en los municipios severamente vulnerables y en los pequenos.

RESUMO Introdução: O arranjo institucional de implementação do Projeto Mais Médicos Brasil (PMMB) envolve diversos atores governamentais e não governamentais em níveis distintos da federação. Trata-se de um complexo arranjo conduzido de forma intersetorial e colaborativa, que demanda a mobilização de capacidade de coordenar e articular os responsáveis por sua condução. Sendo assim, analisaram-se as implicações dos arranjos institucionais e de suas inter-relações com as capacidades estatais, que podem afetar o desempenho e a entrega dos objetivos pretendidos pela intervenção. Materiais e métodos: Para tanto, realizaram-se oito entrevistas com atores-chaves, ligados direta ou indiretamente à implementação do projeto, em nível federal, no período de julho de 2018 a janeiro de 2019, bem como análise documental. Resultados: Os resultados apontam que, no começo, o arranjo facilitou a construção de capacidades técnico-administrativa e político-relacional que permitiram superar os desafios, em termos de coordenação dos diversos atores e das burocracias, em nível interfederativo, a fim de levar médicos aos locais desassistidos ou com dificuldades de fixá-los. Entre outras questões, contribuíram neste processo a aceitação social da intervenção, a geração de resultados em curto prazo e a centralidade da política na agenda governamental. Entretanto alterações, no contexto sociopolítico, que culminaram, em mudança governamental e de atores centrais quanto ao arranjo de implementação, aliado à resistência de grupos de interesse, enfraqueceram as capacidades de entrega dos resultados da intervenção. Discussão: Fica evidente que as capacidades de implementação de uma política pública não são fixas e demandam constante ativação de seu arranjo institucional.

ABSTRACT Introduction: The institutional arrangement for implementation of the More Doctors Project Brazil (PMMB) involves various governmental and non-governmental actors at different levels of the federation. It is a complex arrangement conducted in an intersectoral and collaborative manner, which requires mobilization of coordination and articulation capacities of those responsible for its conduct. As a result, we analyzed the implications of institutional arrangements and their interrelationships with state capacities, which may affect the performance and delivery of the intended objectives of the intervention. Materials and methods: To this end, 8 interviews were conducted with key actors, directly or indirectly linked to the implementation of the project at the federal level, from July 2018 to January 2019, as well as documentary analysis. Results: The results indicate that, initially, the arrangement facilitated the construction of technical-administrative and political-relational capacities that allowed to overcome the challenges in terms of coordination of the various actors and bureaucracies at the inter-federative level, in order to take doctors to unassisted or unsafe places. difficulties in fixing them. Among other issues, the social acceptance of the intervention, the generation of short-term results and the centrality of the policy on the government agenda contributed to this process. However, changes in the socio-political context, which culminated in government change and central actors responsible for the implementation arrangement, combined with the resistance of pressure groups, weakened the ability to deliver the expected outcomes. Discussion: Therefore, it is evident that the implementation capacities of a public policy are not fixed and demand constant activation of its institutional arrangement.

RESUMO Objetivos Revisar a literatura científica sobre as principais técnicas usadas para gerar o potencial evocado miogênico vestibular (VEMP) e suas aplicações clínicas. Estratégia de pesquisa Os artigos que descrevem os métodos de registro e as aplicações do VEMP foram localizados nas bases de dados PubMed, Web of Science, MEDLINE, Scopus, LILACS e SciELO. O levantamento realizado limitou-se aos artigos publicados nos idiomas Inglês, Português e Espanhol, entre janeiro de 2012 e maio de 2018. Critérios de seleção Artigos sobre os aspectos técnicos para a realização do VEMP ocular, cervical ou do músculo sóleo, com estimulação auditiva ou galvânica e artigos sobre as aplicações clínicas do VEMP foram incluídos; artigos repetidos nas bases de dados, artigos de revisão de literatura, relato de casos, cartas e editoriais foram excluídos. Resultados A estratégia de busca resultou na seleção de 28 artigos. Os estudos evidenciaram três métodos de registro do VEMP: cervical, ocular e no músculo sóleo. As aplicações clínicas do VEMP incluíram doença de Ménière, neurite vestibular, síndrome da deiscência do canal semicircular superior, doença de Parkinson, lesões centrais isquêmicas e mielopatias motoras. Conclusão Independentemente da técnica de registro, o VEMP mostrou-se útil como ferramenta complementar para o diagnóstico de doenças vestibulares periféricas e centrais.

ABSTRACT Purpose To review the scientific literature on the main techniques used to generate vestibular-evoked myogenic potential (VEMP) and its clinical applications. Research strategy A search for articles describing VEMP recording methods and applications was conducted in the PubMed, Web of Science, MEDLINE, Scopus, LILACS and SciELO databases. The search was limited to articles published in English, Portuguese, and Spanish between January 2012 and May 2018. Selection criteria Articles addressing the technical aspects for performing ocular, cervical or soleus VEMP with auditory or galvanic stimulation and articles on the clinical applications of VEMP were included in this review, whereas articles repeated in the databases, literature reviews, case reports, letters, and editorials were excluded. Results The search strategy resulted in the selection of 28 articles. The studies evidenced three methods of VEMP recording: responses from the cervical, ocular and soleus muscle. Clinical applications of VEMP included Meniere’s disease, vestibular neuritis, superior semicircular canal dehiscence syndrome, Parkinson's disease, central ischemic lesions, and motor myelopathies. Conclusion Regardless of the recording technique, VEMP has proved to be useful as a complementary tool for the diagnosis of peripheral and central vestibular diseases.

OBJECTIVE: This randomized clinical trial evaluated the possibility of not draining the axilla following axillary dissection. METHODS: The study included 240 breast cancer patients who underwent axillary dissection as part of conservative treatment. The patients were divided into two groups depending on whether or not they were subjected to axillary drainage. ClinicalTrials.gov: NCT01267552. RESULTS: The median volume of fluid aspirated was significantly lower in the axillary drainage group (0.00 ml; 0.00 - 270.00) compared to the no drain group (522.50 ml; 130.00 - 1148.75). The median number of aspirations performed during conservative breast cancer treatment was significantly lower in the drainage group (0.5; 0.0 - 4.0) compared to the no drain group (5.0; 3.0 - 7.0). The total volume of serous fluid produced (the volume of fluid obtained from drainage added to the volume of aspirated fluid) was similar in the two groups. Regarding complications, two cases (2.4%) of wound dehiscence occurred in the drainage group compared to 13 cases (13.5%) in the group in which drainage was not performed, with this difference being statistically significant. Rates of infection, necrosis and hematoma were similar in both groups. CONCLUSION: Safety rates were similar in both study groups; hence, axillary dissection can feasibly be performed without drainage. However, more needle aspirations could be required, and there could be more cases of wound dehiscence in patients who do not undergo auxiliary drainage.

Resumo Introdução: O potencial evocado miogênico vestibular é um potencial de média latência que avalia a resposta muscular decorrente de estimulação auditiva. Pode ser gerado a partir da contração do músculo esternocleidomastóideo e também a partir da contração de músculos extraoculares em resposta a sons de elevada intensidade. Este estudo apresenta uma técnica combinada ou simultânea de potencial evocado miogênico vestibular cervical e ocular em indivíduos com alterações no sistema vestibular para que possa ser usada no diagnóstico otoneurológico. Objetivo: Caracterizar o registro e analisar os resultados do potencial evocado miogênico vestibular cervical e ocular combinado em indivíduos com hiporreflexia vestibular e em indivíduos com doença de Ménière. Método: Participaram do estudo 120 indivíduos, 30 com hiporreflexia vestibular, 30 com doença de Ménière e 60 com audição dentro dos padrões de normalidade. A coleta de dados foi feita por meio do potencial evocado miogênico vestibular cervical e ocular registrados simultaneamente. Resultados: Houve diferença entre o grupo de estudo (indivíduos com hiporreflexia vestibular e indivíduos com doença de Ménière) e o grupo controle para a maioria dos parâmetros das ondas no potencial evocado miogênico vestibular cervical e ocular combinado. Para o potencial evocado miogênico vestibular cervical observou-se que o prolongamento da latência das ondas P13 e N23 foi a alteração mais encontrada no grupo de indivíduos com hiporreflexia vestibular e no grupo de indivíduos com doença de Ménière. Para o potencial evocado miogênico vestibular ocular o prolongamento da latência das ondas N10 e P15 foi a alteração mais encontrada no grupo de estudo. Conclusão: O potencial evocado miogênico vestibular cervical e ocular combinado apresentou resultados relevantes para os indivíduos com hiporreflexia vestibular e para os indivíduos com doença de Ménière. Houve diferença entre o grupo de estudo e o grupo controle para a maioria dos parâmetros das ondas no potencial evocado miogênico vestibular cervical e ocular combinado.

Abstract Introduction: The vestibular evoked myogenic potential is a potential of mean latency that measures the muscle response to auditory stimulation. This potential can be generated from the contraction of the sternocleidomastoid muscle and also from the contraction of extraocular muscles in response to high-intensity sounds. This study presents a combined or simultaneous technique of cervical and ocular vestibular evoked myogenic potential in individuals with changes in the vestibular system, for use in otoneurologic diagnosis. Objective: To characterize the records and analyze the results of combined cervical and ocular VEMP in individuals with vestibular hyporeflexia and in those with Ménière's disease. Methods: The study included 120 subjects: 30 subjects with vestibular hyporeflexia, 30 with Ménière's disease, and 60 individuals with normal hearing. Data collection was performed by simultaneously recording the cervical and ocular vestibular evoked myogenic potential. Results: There were differences between the study groups (individuals with vestibular hyporeflexia and individuals with Ménière's disease) and the control group for most of wave parameters in combined cervical and ocular vestibular evoked myogenic potential. For cervical vestibular evoked myogenic potential, it was observed that the prolongation of latency of the P13 and N23 waves was the most frequent finding in the group with vestibular hyporeflexia and in the group with Ménière's disease. For ocular vestibular evoked myogenic potential, prolonged latency of N10 and P15 waves was the most frequent finding in the study groups. Conclusion: Combined cervical and ocular vestibular evoked myogenic potential presented relevant results for individuals with vestibular hyporeflexia and for those with Ménière's disease. There were differences between the study groups and the control group for most of the wave parameters in combined cervical and ocular vestibular evoked myogenic potential.

RESUMO Objetivo: Caracterizar o registro e analisar os resultados do potencial evocado miogênico vestibular cervical e ocular combinado em indivíduos sem queixas auditivas e vestibulares. Métodos: Participaram da pesquisa 30 indivíduos sem queixa auditiva e com audição dentro dos padrões de normalidade. A coleta de dados foi realizada por meio do potencial evocado miogênico vestibular cervical e ocular registrados simultaneamente. Resultados: Houve diferença entre as orelhas direita e esquerda para a amplitude das ondas P13 e N23 do potencial evocado miogênico vestibular cervical e para a latência da onda N10 do potencial evocado miogênico vestibular ocular. No gênero feminino não houve diferença entre as orelhas direita e esquerda para a amplitude das ondas P13, N23, N10, P15, interamplitude no potencial evocado miogênico vestibular cervical e interamplitude no potencial evocado miogênico vestibular ocular e para a latência das ondas P13, N23, N10 e P15. No gênero masculino houve diferença entre as orelhas direita e esquerda para a amplitude da onda P13. Conclusão: Os resultados do potencial evocado miogênico vestibular cervical e ocular combinado foram consistentes, uma vez que as respostas geradas pelos potenciais evocados miogênicos vestibulares apresentaram morfologia, latência e amplitude adequadas, o que permite a avaliação da via vestibular ipsilateral descendente e da via vestibular contralateral ascendente.

ABSTRACT Purpose: To characterize the recording and analyze the results of the combined cervical and ocular vestibular evoked myogenic potential in individuals without hearing and vestibular complaints. Methods: In this study, 30 individuals without hearing complaints and hearing within normal limits were evaluated. Data were collected through the simultaneous recording of cervical and ocular vestibular evoked myogenic potential. Results: Differences were observed between the right and left ears for the amplitude of waves P13 and N23 of the cervical vestibular evoked myogenic potential and the latency of wave N10 of the ocular vestibular evoked myogenic potential. For female subjects, there was no difference between the right and left ears for the amplitude of waves P13, N23, N10, and P15; interamplitude in cervical vestibular evoked myogenic potential and interamplitude in ocular vestibular evoked myogenic potential; and latency in waves P13, N23, N10, and P15. For male subjects, there was a difference between the right and left ears for the amplitude of wave P13. Conclusion: The results of the combined cervical and ocular vestibular evoked myogenic potentials were consistent, because the responses generated by the vestibular evoked myogenic potentials presented an adequate morphology, latency, and amplitude, allowing for the evaluation of the ipsilateral descending vestibular pathways and the contralateral ascending vestibular pathways.

RESUMO Objetivo Identificar e sistematizar os principais estudos sobre o potencial evocado miogênico vestibular ocular e suas aplicações no diagnóstico das diversas doenças vestibulares. Estratégia de pesquisa Foram localizados artigos que descrevem a utilização do potencial evocado miogênico vestibular ocular na avaliação de doenças vestibulares nas bases PubMed, Web of Science, MEDLINE, Scopus, LILACS e SciELO. Critérios de seleção Foram incluídos estudos originais, com resumo disponível, publicados no período de janeiro de 2010 a março de 2016. Análise dos dados Foi realizada a descrição do delineamento do estudo e elencados os achados para a avaliação de potencial evocado miogênico vestibular ocular. Resultados Foram encontrados 265 estudos, dos quais 14 contemplaram os critérios de seleção propostos. Em relação à população/amostra de pacientes com alterações vestibulares incluída nos estudos, observou-se que as doenças mais investigadas foram a neurite vestibular, a vertigem posicional paroxística benigna, o Schwanoma vestibular e a doença de Ménière. Conclusão A maior parte das pesquisas realizadas nos últimos anos e publicadas nas bases de dados PubMed, Web of Science, MEDLINE e Scopus revelou que o potencial evocado miogênico vestibular ocular representa um método eficaz para avaliar a função utricular nas mais diversas doenças vestibulares.

ABSTRACT Purpose To identify and systematize the main studies on the ocular vestibular evoked myogenic potentials and their applications in the diagnosis of various vestibular diseases. Research strategy Articles that describe the use of ocular vestibular evoked myogenic potentials the evaluation of vestibular diseases were located in PubMed, Web of Science, MEDLINE, Scopus, LILACS e SciELO. Selection criteria Original studies, with available abstract, published in the period 2010 to March 2016 were included. Data analysis The study design was described, and the characteristics for the evaluation of ocular vestibular evoked myogenic potentials were listed. Results 265 studies were found, but just 14 contemplated the proposed selection criteria. In relation to the population / sample of patients with vestibular disorders included in the study, it was observed that the most researched diseases were the vestibular neuritis, benign paroxysmal positional vertigo, vestibular Schwanoma and Meniere’s disease. Conclusion The most of the research realized in recent years and published in the databases PubMed, Web of Science, MEDLINE and Scopus revealed that the ocular vestibular evoked myogenic potentials is an effective method to evaluate the utricular function in various vestibular disorders.

ABSTRACT Objective: The purpose of this video is to present the laparoscopic repair of a VUF in a 42-year-old woman, with gross hematuria, in the immediate postoperative phase following a cesarean delivery. The obstetric team implemented conservative management, including Foley catheter insertion, for 2 weeks. She subsequently developed intermittent hematuria and cystitis. The urology team was consulted 15 days after cesarean delivery. Cystoscopy indicated an ulcerated lesion in the bladder dome of approximately 1.0cm in size. Hysterosalpingography and a pelvic computed tomography scan indicated a fistula. Materials and Methods: Laparoscopic repair was performed 30 days after the cesarean delivery. The patient was placed in the lithotomy position while also in an extreme Trendelenburg position. Pneumoperitoneum was established using a Veress needle in the midline infra-umbilical region, and a primary 11-mm port was inserted. Another 11-mm port was inserted exactly between the left superior iliac spine and the umbilicus. Two other 5-mm ports were established under laparoscopic guidance in the iliac fossa on both sides. The omental adhesions in the pelvis were carefully released and the peritoneum between the bladder and uterus was incised via cautery. Limited cystotomy was performed, and the specific sites of the fistula and the ureteral meatus were identified; thereafter, the posterior bladder wall was adequately mobilized away from the uterus. The uterine rent was then closed using single 3/0Vicryl sutures and two-layer watertight closure of the urinary bladder was achieved by using 3/0Vicryl sutures. An omental flap was mobilized and inserted between the uterus and the urinary bladder, and was fixed using two 3/0Vicryl sutures, followed by tube drain insertion. Results: The operative time was 140 min, whereas the blood loss was 100ml. The patient was discharged 3 days after surgery, and the catheter was removed 12 days after surgery. Discussion: Laparoscopy has advantages over open surgery in that it is associated with less pain, shorter length of hospital stay, better cosmesis, quicker recovery, and equal efficacy. Although cases of VUF are rarely noted, the laparoscopic skill obtained through other urological procedures suggest, that laparoscopic repair may be the procedure of choice for such cases (2). The reported operative time for the laparoscopic repair of VUF in the literature varies between 140 and 220 min (3). However, laparoscopic techniques should be considered as a mode of abdominal access and should not influence the method of surgical repair. Surgical success should depend on the adherence to good technique rather than the approach. Hence, this method appears to be a viable alternative for surgeons experienced with laparoscopic suturing techniques. Conclusion: Laparoscopic repair appears to be a viable alternative for surgeons experienced with laparoscopic suturing techniques.

Management of children with HIV/AIDS is specially challenging. Age-related issues do not allow for direct transposition of adult observations to this population. CXCR4 tropism has been associated with disease progression in adults. The geno2pheno web-base is a friendly tool to predict viral tropism on envelope V3 sequences, generating a false positive rate for a CXCR4 prediction. We evaluated the association of HIV-1 tropism prediction with clinical and laboratory outcome of 73 children with HIV/AIDS in São Paulo, Brazil. The CXCR4 tropism was strongly associated with a lower (nadir) CD4 documented during follow-up (p < 0.0001) and with disease severity (clinical event and/or CD4 below 200 cells/mm3) at the last observation, using commonly applied clinical cutoffs, such as10%FPRclonal (p = 0.001). When variables obtained during follow-up are included, both treatment adherence and viral tropism show a significant association with disease severity. As for viremia suppression, 30% (22/73) were undetectable at the last observation, with only adherence strongly associated with suppression after adjustment. The study brings further support to the notion that antiretroviral treatment adherence is pivotal to management of HIV disease, but suggests that tropism prediction may provide an additional prognostic marker to monitor HIV disease in children.